WDFY3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.77536686
2synaptic vesicle maturation (GO:0016188)4.72250774
3locomotory exploration behavior (GO:0035641)4.65026388
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.43565315
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.20970879
6vocalization behavior (GO:0071625)4.01081950
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.86261693
8cellular potassium ion homeostasis (GO:0030007)3.83442367
9layer formation in cerebral cortex (GO:0021819)3.82860533
10synaptic vesicle exocytosis (GO:0016079)3.75274097
11cerebellar Purkinje cell differentiation (GO:0021702)3.74968328
12glutamate secretion (GO:0014047)3.68374556
13sodium ion export (GO:0071436)3.67688073
14regulation of glutamate receptor signaling pathway (GO:1900449)3.65981969
15ionotropic glutamate receptor signaling pathway (GO:0035235)3.59768168
16dendrite morphogenesis (GO:0048813)3.58542061
17regulation of synaptic vesicle exocytosis (GO:2000300)3.53930835
18synaptic vesicle docking involved in exocytosis (GO:0016081)3.53202415
19gamma-aminobutyric acid transport (GO:0015812)3.43613629
20protein localization to synapse (GO:0035418)3.40473412
21exploration behavior (GO:0035640)3.39831677
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.39478423
23neurotransmitter secretion (GO:0007269)3.38241638
24regulation of synapse structural plasticity (GO:0051823)3.38194310
25cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.30791641
26establishment of nucleus localization (GO:0040023)3.29769554
27glutamate receptor signaling pathway (GO:0007215)3.19729022
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.19501108
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.18900902
30dendritic spine morphogenesis (GO:0060997)3.18488755
31synaptic vesicle endocytosis (GO:0048488)3.18355665
32regulation of neuronal synaptic plasticity (GO:0048168)3.16977352
33neurotransmitter-gated ion channel clustering (GO:0072578)3.16512115
34cell communication by electrical coupling (GO:0010644)3.16226882
35regulation of synaptic vesicle transport (GO:1902803)3.10820554
36activation of protein kinase A activity (GO:0034199)3.09607575
37proline transport (GO:0015824)3.08421677
38import into cell (GO:0098657)3.06898298
39axonal fasciculation (GO:0007413)3.06575962
40regulation of long-term neuronal synaptic plasticity (GO:0048169)3.05524166
41neuromuscular process controlling balance (GO:0050885)3.05093658
42regulation of ARF protein signal transduction (GO:0032012)3.04537701
43neuron cell-cell adhesion (GO:0007158)3.04273413
44membrane depolarization during action potential (GO:0086010)3.03744240
45regulation of clathrin-mediated endocytosis (GO:2000369)3.03244388
46synaptic transmission, glutamatergic (GO:0035249)3.02094966
47detection of molecule of bacterial origin (GO:0032490)2.93845202
48neuron recognition (GO:0008038)2.92898526
49positive regulation of synapse maturation (GO:0090129)2.92159986
50vesicle transport along microtubule (GO:0047496)2.92027959
51cerebellar granule cell differentiation (GO:0021707)2.90878967
52L-amino acid import (GO:0043092)2.88874142
53response to pheromone (GO:0019236)2.88561102
54neuronal action potential propagation (GO:0019227)2.88374220
55negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.85161701
56regulation of excitatory postsynaptic membrane potential (GO:0060079)2.84586441
57positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.82833876
58long-term memory (GO:0007616)2.82701164
59positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.79748606
60regulation of postsynaptic membrane potential (GO:0060078)2.79594651
61presynaptic membrane assembly (GO:0097105)2.78569909
62potassium ion import (GO:0010107)2.76491327
63neuron-neuron synaptic transmission (GO:0007270)2.72794269
64neurotransmitter transport (GO:0006836)2.71168271
65cell migration in hindbrain (GO:0021535)2.71101448
66embryonic retina morphogenesis in camera-type eye (GO:0060059)2.69723279
67nucleus localization (GO:0051647)2.69488392
68clathrin coat assembly (GO:0048268)2.67078912
69presynaptic membrane organization (GO:0097090)2.66631880
70cell differentiation in hindbrain (GO:0021533)2.66240798
71neuromuscular process controlling posture (GO:0050884)2.62060533
72cellular sodium ion homeostasis (GO:0006883)2.61711663
73organelle transport along microtubule (GO:0072384)2.61038953
74potassium ion homeostasis (GO:0055075)2.60910604
75glycine transport (GO:0015816)2.60639312
76regulation of dendritic spine morphogenesis (GO:0061001)2.60194217
77membrane depolarization (GO:0051899)2.59236604
78cytoskeletal anchoring at plasma membrane (GO:0007016)2.58967557
79phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.58859510
80amino acid import (GO:0043090)2.57937769
81response to auditory stimulus (GO:0010996)2.56543880
82transmission of nerve impulse (GO:0019226)2.55531147
83G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.55228188
84positive regulation of membrane potential (GO:0045838)2.54492624
85regulation of neurotransmitter secretion (GO:0046928)2.53367046
86alanine transport (GO:0032328)2.53351958
87neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.53179633
88membrane hyperpolarization (GO:0060081)2.52829219
89innervation (GO:0060384)2.52623094
90nerve growth factor signaling pathway (GO:0038180)2.52277965
91regulation of synaptic transmission, glutamatergic (GO:0051966)2.50977762
92regulation of neurotransmitter levels (GO:0001505)2.50840593
93regulation of synaptic plasticity (GO:0048167)2.50591004
94central nervous system myelination (GO:0022010)2.47826412
95axon ensheathment in central nervous system (GO:0032291)2.47826412
96cytoplasmic mRNA processing body assembly (GO:0033962)2.47809237
97positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.47444870
98prepulse inhibition (GO:0060134)2.47074715
99negative regulation of neurotransmitter secretion (GO:0046929)2.46158675
100auditory behavior (GO:0031223)2.45970399
101neuromuscular process (GO:0050905)2.45584503
102cell communication involved in cardiac conduction (GO:0086065)2.45210900
103phospholipid translocation (GO:0045332)2.44775613
104lipid translocation (GO:0034204)2.44775613
105adult walking behavior (GO:0007628)2.43356321
106positive regulation of potassium ion transmembrane transport (GO:1901381)2.43229827
107mating behavior (GO:0007617)2.41069458
108interkinetic nuclear migration (GO:0022027)2.40301854
109synapse assembly (GO:0007416)2.38908841
110establishment of protein localization to Golgi (GO:0072600)2.37747217
111neuronal ion channel clustering (GO:0045161)2.37235402
112central nervous system projection neuron axonogenesis (GO:0021952)2.36917198
113synapse organization (GO:0050808)2.36717680
114regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.36141254
115negative regulation of inclusion body assembly (GO:0090084)2.35995933
116protein targeting to Golgi (GO:0000042)2.35155043
117insulin-like growth factor receptor signaling pathway (GO:0048009)2.34067130
118cellular response to epinephrine stimulus (GO:0071872)2.31944445
119cellular response to ethanol (GO:0071361)2.30929003
120Golgi to endosome transport (GO:0006895)2.28170634
121peptidyl-threonine phosphorylation (GO:0018107)2.27778092
122positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.26786711
123iron ion import (GO:0097286)2.23965288
124positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.21707257
125peptidyl-threonine modification (GO:0018210)2.20441580
126cellular response to monoamine stimulus (GO:0071868)2.19260042
127cellular response to catecholamine stimulus (GO:0071870)2.19260042
128regulation of beta-amyloid formation (GO:1902003)2.17778844
129negative regulation of vascular permeability (GO:0043116)2.17195753
130membrane assembly (GO:0071709)2.16708884
131negative regulation of neurotransmitter transport (GO:0051589)2.13729374
132suckling behavior (GO:0001967)2.11480206
133plasma membrane repair (GO:0001778)2.10945683
134positive regulation of receptor recycling (GO:0001921)2.10379143
135negative regulation of cytosolic calcium ion concentration (GO:0051481)2.09208558
136peripheral nervous system axon ensheathment (GO:0032292)2.03318976
137myelination in peripheral nervous system (GO:0022011)2.03318976
138early endosome to late endosome transport (GO:0045022)2.03028513
139embryonic camera-type eye morphogenesis (GO:0048596)2.02969674
140regulation of axon extension involved in axon guidance (GO:0048841)2.01882887
141interleukin-6-mediated signaling pathway (GO:0070102)2.01635435
142cortical actin cytoskeleton organization (GO:0030866)2.00962955
143regulation of protein polyubiquitination (GO:1902914)2.00869746
144central nervous system neuron axonogenesis (GO:0021955)2.00501065
145histone H3-K36 demethylation (GO:0070544)2.00013691
146hypotonic response (GO:0006971)1.99872685
147neuromuscular junction development (GO:0007528)1.98673695
148postsynaptic membrane organization (GO:0001941)1.98172435
149negative regulation of Rho protein signal transduction (GO:0035024)1.97311133
150retrograde transport, vesicle recycling within Golgi (GO:0000301)1.97187126
151negative regulation of dendrite morphogenesis (GO:0050774)1.96348150
152myelination (GO:0042552)1.94913470
153response to epinephrine (GO:0071871)1.94069622
154regulation of NFAT protein import into nucleus (GO:0051532)1.93865263
155response to catecholamine (GO:0071869)1.93119234
156response to monoamine (GO:0071867)1.93119234
157platelet-derived growth factor receptor signaling pathway (GO:0048008)1.92104477
158regulation of axon regeneration (GO:0048679)1.91748812
159regulation of neuron projection regeneration (GO:0070570)1.91748812
160growth hormone receptor signaling pathway (GO:0060396)1.91734637
161positive regulation of calcium ion transmembrane transporter activity (GO:1901021)1.91575287
162histone H3-K9 demethylation (GO:0033169)1.91519045
163morphogenesis of an epithelial sheet (GO:0002011)1.91439415
164relaxation of cardiac muscle (GO:0055119)1.91379771

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.09087709
2GBX2_23144817_ChIP-Seq_PC3_Human3.03329474
3DROSHA_22980978_ChIP-Seq_HELA_Human2.57906629
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43570596
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.33932986
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23668291
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.20068677
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19896196
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17545033
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17545033
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08194649
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02420345
13REST_21632747_ChIP-Seq_MESCs_Mouse2.00093855
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99078791
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96671664
16JARID2_20075857_ChIP-Seq_MESCs_Mouse1.94272910
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90584072
18RARB_27405468_Chip-Seq_BRAIN_Mouse1.89939336
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.86400258
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.78321383
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.77497200
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.74858098
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.72632938
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70298015
25* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70286132
26AR_21572438_ChIP-Seq_LNCaP_Human1.66157638
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62782148
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56075514
29SMAD4_21799915_ChIP-Seq_A2780_Human1.55773748
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.52068915
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51901808
32* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48741995
33NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.43968559
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.43968559
35AHR_22903824_ChIP-Seq_MCF-7_Human1.43370059
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.42219388
37* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.41476364
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40934282
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36157316
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35534832
41ARNT_22903824_ChIP-Seq_MCF-7_Human1.35232284
42ZNF274_21170338_ChIP-Seq_K562_Hela1.33043980
43CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.32383381
44ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31474807
45* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.31234395
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31023776
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30863246
48STAT3_23295773_ChIP-Seq_U87_Human1.30051931
49* SOX2_21211035_ChIP-Seq_LN229_Gbm1.29441624
50TP53_16413492_ChIP-PET_HCT116_Human1.29087308
51KDM2B_26808549_Chip-Seq_K562_Human1.28986236
52AR_19668381_ChIP-Seq_PC3_Human1.27967740
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25918085
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25665075
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.24909075
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24511664
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23940945
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23532729
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22371915
60* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21960136
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21798596
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.21008445
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20335264
64* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19813127
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19234481
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.19136192
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.18191572
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17802216
69* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17052037
70FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16543083
71STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16453322
72* EP300_21415370_ChIP-Seq_HL-1_Mouse1.15365555
73AR_25329375_ChIP-Seq_VCAP_Human1.14416553
74LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12430243
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12320598
76SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12226105
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.11959216
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11516453
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.10951676
80TCF4_23295773_ChIP-Seq_U87_Human1.10907572
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10377304
82TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10097310
83CJUN_26792858_Chip-Seq_BT549_Human1.09261593
84GATA2_21666600_ChIP-Seq_HMVEC_Human1.08394767
85ISL1_27105846_Chip-Seq_CPCs_Mouse1.08093850
86* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07974638
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.07835412
88TCF4_18268006_ChIP-ChIP_LS174T_Human1.07531973
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07071540
90PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06838615
91SMAD3_21741376_ChIP-Seq_HESCs_Human1.06509341
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06463389
93CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06365697
94NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06234480
95* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05980870
96KDM2B_26808549_Chip-Seq_REH_Human1.05907279
97ESR2_21235772_ChIP-Seq_MCF-7_Human1.05702440
98TP53_18474530_ChIP-ChIP_U2OS_Human1.04942159
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04914847
100FOXO3_23340844_ChIP-Seq_DLD1_Human1.04787983
101* P300_19829295_ChIP-Seq_ESCs_Human1.04277036
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04177465
103TAF15_26573619_Chip-Seq_HEK293_Human1.03579365
104SMAD4_21741376_ChIP-Seq_HESCs_Human1.03548948
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03070620
106SMAD_19615063_ChIP-ChIP_OVARY_Human1.03010210
107* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02516316
108EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01819970
109FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01576902
110TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01247708
111RING1B_27294783_Chip-Seq_NPCs_Mouse1.00732477
112ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00691046
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00348483
114* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00346437
115RXR_22108803_ChIP-Seq_LS180_Human1.00250270
116FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.00139420
117NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00113036
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99994104
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99917688
120ESR1_20079471_ChIP-ChIP_T-47D_Human0.99434421
121* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99163955
122* SMAD3_21741376_ChIP-Seq_ESCs_Human0.98190415
123P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97231528
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95761707
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95761707
126CBX2_27304074_Chip-Seq_ESCs_Mouse0.94072609
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93825352
128RUNX2_22187159_ChIP-Seq_PCA_Human0.92021937
129GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91830478
130FOXA2_19822575_ChIP-Seq_HepG2_Human0.91487786
131BCAT_22108803_ChIP-Seq_LS180_Human0.91391585

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.64779262
2MP0000569_abnormal_digit_pigmentation4.45259010
3MP0003635_abnormal_synaptic_transmissio3.52016377
4MP0009046_muscle_twitch3.34832270
5MP0004270_analgesia3.23703673
6MP0003880_abnormal_central_pattern3.12824896
7MP0002063_abnormal_learning/memory/cond2.73216419
8MP0002064_seizures2.65392693
9MP0009745_abnormal_behavioral_response2.60549990
10MP0005423_abnormal_somatic_nervous2.55360971
11MP0009780_abnormal_chondrocyte_physiolo2.27161995
12MP0001486_abnormal_startle_reflex2.26970632
13MP0002734_abnormal_mechanical_nocicepti2.25207912
14MP0002572_abnormal_emotion/affect_behav2.21309615
15MP0004858_abnormal_nervous_system2.14233736
16MP0001968_abnormal_touch/_nociception2.14223292
17MP0002272_abnormal_nervous_system2.01170122
18MP0010352_gastrointestinal_tract_polyps1.96540791
19MP0000778_abnormal_nervous_system1.92121770
20MP0003091_abnormal_cell_migration1.81413457
21MP0002067_abnormal_sensory_capabilities1.78666816
22MP0001501_abnormal_sleep_pattern1.73288369
23MP0008569_lethality_at_weaning1.71118861
24MP0001984_abnormal_olfaction1.71018658
25MP0001440_abnormal_grooming_behavior1.70537961
26MP0003329_amyloid_beta_deposits1.69321890
27MP0003690_abnormal_glial_cell1.68077697
28MP0002184_abnormal_innervation1.67365827
29MP0004811_abnormal_neuron_physiology1.66883663
30MP0005275_abnormal_skin_tensile1.63319639
31MP0005248_abnormal_Harderian_gland1.62914501
32MP0003172_abnormal_lysosome_physiology1.61531501
33MP0008057_abnormal_DNA_replication1.57254964
34MP0002733_abnormal_thermal_nociception1.55497693
35MP0002909_abnormal_adrenal_gland1.53645513
36MP0003828_pulmonary_edema1.51384224
37MP0002735_abnormal_chemical_nociception1.50929967
38MP0003941_abnormal_skin_development1.49778340
39MP0002557_abnormal_social/conspecific_i1.49606278
40MP0005551_abnormal_eye_electrophysiolog1.49162053
41MP0004145_abnormal_muscle_electrophysio1.48564125
42MP0004272_abnormal_basement_membrane1.48186236
43MP0003633_abnormal_nervous_system1.46640497
44MP0000955_abnormal_spinal_cord1.46257267
45MP0008438_abnormal_cutaneous_collagen1.45946054
46MP0003122_maternal_imprinting1.45803556
47MP0004885_abnormal_endolymph1.45273125
48MP0001970_abnormal_pain_threshold1.42914058
49MP0010678_abnormal_skin_adnexa1.42640739
50MP0005646_abnormal_pituitary_gland1.42253491
51MP0002882_abnormal_neuron_morphology1.41317074
52MP0003283_abnormal_digestive_organ1.41006786
53MP0002736_abnormal_nociception_after1.39880137
54MP0010368_abnormal_lymphatic_system1.38624901
55MP0005386_behavior/neurological_phenoty1.37460223
56MP0004924_abnormal_behavior1.37460223
57MP0001299_abnormal_eye_distance/1.36303037
58MP0010234_abnormal_vibrissa_follicle1.35973782
59MP0004233_abnormal_muscle_weight1.35109861
60MP0003566_abnormal_cell_adhesion1.34670758
61MP0000751_myopathy1.34463364
62MP0003787_abnormal_imprinting1.30242929
63MP0003631_nervous_system_phenotype1.28896211
64MP0005076_abnormal_cell_differentiation1.28376874
65MP0000383_abnormal_hair_follicle1.27377168
66MP0003632_abnormal_nervous_system1.25714559
67MP0003045_fibrosis1.25460747
68MP0008961_abnormal_basal_metabolism1.24462467
69MP0005645_abnormal_hypothalamus_physiol1.22773802
70MP0002066_abnormal_motor_capabilities/c1.21240306
71MP0003634_abnormal_glial_cell1.21234595
72MP0000604_amyloidosis1.21052671
73MP0002090_abnormal_vision1.20467569
74MP0003724_increased_susceptibility_to1.20420714
75MP0003890_abnormal_embryonic-extraembry1.19004792
76MP0003879_abnormal_hair_cell1.15151451
77MP0002133_abnormal_respiratory_system1.14572010
78MP0005388_respiratory_system_phenotype1.14572010
79MP0002229_neurodegeneration1.14050698
80MP0002152_abnormal_brain_morphology1.12542164
81MP0001915_intracranial_hemorrhage1.12011344
82MP0005623_abnormal_meninges_morphology1.11284044
83MP0002168_other_aberrant_phenotype1.10687750
84MP0001502_abnormal_circadian_rhythm1.10466078
85MP0006054_spinal_hemorrhage1.10370936
86MP0004084_abnormal_cardiac_muscle1.05773974
87MP0003300_gastrointestinal_ulcer1.05531258
88MP0001177_atelectasis1.05365962
89MP0002822_catalepsy1.04644979
90MP0005174_abnormal_tail_pigmentation1.01243829
91MP0000428_abnormal_craniofacial_morphol1.01195427
92MP0006276_abnormal_autonomic_nervous0.98346445
93MP0004130_abnormal_muscle_cell0.98277739
94MP0002332_abnormal_exercise_endurance0.97819004
95MP0000767_abnormal_smooth_muscle0.96825234
96MP0003075_altered_response_to0.95964044
97MP0000427_abnormal_hair_cycle0.95900525
98MP0005595_abnormal_vascular_smooth0.95851405
99MP0003950_abnormal_plasma_membrane0.95751506
100MP0004883_abnormal_blood_vessel0.94024682
101MP0002896_abnormal_bone_mineralization0.93792714
102MP0000920_abnormal_myelination0.93455067
103MP0005167_abnormal_blood-brain_barrier0.92160098
104MP0004085_abnormal_heartbeat0.91795612
105MP0003191_abnormal_cellular_cholesterol0.91507763
106MP0002009_preneoplasia0.89757801
107MP0008260_abnormal_autophagy0.89707352
108MP0005187_abnormal_penis_morphology0.89178158
109MP0004742_abnormal_vestibular_system0.89019468
110MP0004510_myositis0.87114744
111MP0004036_abnormal_muscle_relaxation0.86413144
112MP0005164_abnormal_response_to0.84621778
113MP0006138_congestive_heart_failure0.82335312
114MP0000733_abnormal_muscle_development0.80971825
115MP0001879_abnormal_lymphatic_vessel0.80779370
116MP0004142_abnormal_muscle_tone0.79710327
117MP0003279_aneurysm0.78836206
118MP0003137_abnormal_impulse_conducting0.78354533
119MP0010386_abnormal_urinary_bladder0.77757620
120MP0003183_abnormal_peptide_metabolism0.75379775
121MP0008004_abnormal_stomach_pH0.75139492
122MP0003705_abnormal_hypodermis_morpholog0.75091758
123MP0003935_abnormal_craniofacial_develop0.75051907
124MP0002069_abnormal_eating/drinking_beha0.74739610
125MP0004215_abnormal_myocardial_fiber0.73254239
126MP0005409_darkened_coat_color0.72602371
127MP0002752_abnormal_somatic_nervous0.71988513
128MP0000747_muscle_weakness0.66233018
129MP0005253_abnormal_eye_physiology0.65373346
130MP0001958_emphysema0.65304974
131MP0000534_abnormal_ureter_morphology0.63745637
132MP0005535_abnormal_body_temperature0.63349918
133MP0005058_abnormal_lysosome_morphology0.63008432
134MP0002108_abnormal_muscle_morphology0.62984588
135MP0004484_altered_response_of0.62056734
136MP0008874_decreased_physiological_sensi0.61914621
137MP0005195_abnormal_posterior_eye0.61547317
138MP0003861_abnormal_nervous_system0.61015327
139MP0002082_postnatal_lethality0.59200452
140MP0010770_preweaning_lethality0.59200452
141MP0010769_abnormal_survival0.58618752
142MP0001963_abnormal_hearing_physiology0.55492319
143MP0005499_abnormal_olfactory_system0.54501361
144MP0005394_taste/olfaction_phenotype0.54501361

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.42869137
2Focal seizures (HP:0007359)4.23095129
3Myokymia (HP:0002411)4.14571447
4Action tremor (HP:0002345)3.99677155
5Progressive cerebellar ataxia (HP:0002073)3.82316827
6Visual hallucinations (HP:0002367)3.51646309
7Papillary thyroid carcinoma (HP:0002895)3.48429046
8Supranuclear gaze palsy (HP:0000605)3.28804198
9Genetic anticipation (HP:0003743)3.27049971
10Febrile seizures (HP:0002373)3.07143319
11Epileptic encephalopathy (HP:0200134)3.03236206
12Overgrowth (HP:0001548)2.88958160
13Gaze-evoked nystagmus (HP:0000640)2.78545988
14Urinary bladder sphincter dysfunction (HP:0002839)2.74208637
15Abnormality of the lower motor neuron (HP:0002366)2.73180510
16Mutism (HP:0002300)2.69583406
17Excessive salivation (HP:0003781)2.69184873
18Drooling (HP:0002307)2.69184873
19Dysdiadochokinesis (HP:0002075)2.68753338
20Atonic seizures (HP:0010819)2.66519222
21Absence seizures (HP:0002121)2.65435433
22Generalized tonic-clonic seizures (HP:0002069)2.63135545
23Truncal ataxia (HP:0002078)2.62524293
24Arterial tortuosity (HP:0005116)2.61488258
25Ankle clonus (HP:0011448)2.61320865
26Hemiplegia (HP:0002301)2.58779385
27Postural instability (HP:0002172)2.57942582
28Hepatoblastoma (HP:0002884)2.51511956
29Broad-based gait (HP:0002136)2.47296927
30Depression (HP:0000716)2.43539471
31Neurofibrillary tangles (HP:0002185)2.42911441
32Elfin facies (HP:0004428)2.41938922
33Insomnia (HP:0100785)2.40909123
34Dialeptic seizures (HP:0011146)2.39462114
35Impaired smooth pursuit (HP:0007772)2.38225071
36Dysmetria (HP:0001310)2.37389394
37Vascular tortuosity (HP:0004948)2.36444076
38Cerebral inclusion bodies (HP:0100314)2.35322241
39Macroorchidism (HP:0000053)2.35172615
40Subacute progressive viral hepatitis (HP:0006572)2.34920940
41Intention tremor (HP:0002080)2.32622318
42Impaired social interactions (HP:0000735)2.31687012
43Abnormal social behavior (HP:0012433)2.31687012
44Dysmetric saccades (HP:0000641)2.31682773
45Insidious onset (HP:0003587)2.30805759
46Termporal pattern (HP:0011008)2.30805759
47Hemiparesis (HP:0001269)2.30313791
48Scanning speech (HP:0002168)2.29599842
49Hyperacusis (HP:0010780)2.26832258
50Impaired vibration sensation in the lower limbs (HP:0002166)2.26709600
51Abnormality of ocular smooth pursuit (HP:0000617)2.24255458
52Turricephaly (HP:0000262)2.22280477
53Aqueductal stenosis (HP:0002410)2.20686289
54Renovascular hypertension (HP:0100817)2.19879597
55Poor eye contact (HP:0000817)2.19286568
56Urinary urgency (HP:0000012)2.17656688
57Central scotoma (HP:0000603)2.17062828
58Abnormality of the corticospinal tract (HP:0002492)2.16888521
59Pointed chin (HP:0000307)2.16246094
60Aortic aneurysm (HP:0004942)2.15687696
61Vertebral arch anomaly (HP:0008438)2.14700379
62Abnormal eating behavior (HP:0100738)2.14269382
63Hyporeflexia of lower limbs (HP:0002600)2.10319045
64Spastic gait (HP:0002064)2.08964924
65Neuronal loss in central nervous system (HP:0002529)2.08929416
66Absent frontal sinuses (HP:0002688)2.07350246
67Lower limb amyotrophy (HP:0007210)2.07143994
68Inappropriate behavior (HP:0000719)2.06165210
69Abnormality of the ischium (HP:0003174)2.02355963
70Absent speech (HP:0001344)2.00975708
71Diplopia (HP:0000651)1.97460569
72Abnormality of binocular vision (HP:0011514)1.97460569
73Lower limb muscle weakness (HP:0007340)1.96378742
74Laryngomalacia (HP:0001601)1.95888274
75Peritonitis (HP:0002586)1.94904022
76Agitation (HP:0000713)1.94722930
77Torticollis (HP:0000473)1.92772298
78Hypoplasia of the iris (HP:0007676)1.89913130
79Thyroid carcinoma (HP:0002890)1.89887931
80Germ cell neoplasia (HP:0100728)1.89330583
81Papilledema (HP:0001085)1.88385595
82Decreased lacrimation (HP:0000633)1.87436885
83Alacrima (HP:0000522)1.86784794
84Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86477696
85Hypoplastic labia majora (HP:0000059)1.85827646
86Overriding aorta (HP:0002623)1.85461837
87Cerebral aneurysm (HP:0004944)1.84411156
88Abnormality of the distal phalanx of the thumb (HP:0009617)1.84256219
89Status epilepticus (HP:0002133)1.83517161
90Decreased motor nerve conduction velocity (HP:0003431)1.83090172
91Shallow orbits (HP:0000586)1.82567797
92Abnormality of incisor morphology (HP:0011063)1.82358170
93Anxiety (HP:0000739)1.81914406
94Ventricular fibrillation (HP:0001663)1.81638654
95Hyperventilation (HP:0002883)1.81126467
96Stereotypic behavior (HP:0000733)1.80638565
97Progressive inability to walk (HP:0002505)1.79234556
98Mitral stenosis (HP:0001718)1.77129888
99Narrow palate (HP:0000189)1.76919502
100Neoplasm of the heart (HP:0100544)1.75915580
101Obsessive-compulsive behavior (HP:0000722)1.74519758
102Mitral valve prolapse (HP:0001634)1.73522437
103Aortic dissection (HP:0002647)1.73281020
104Truncal obesity (HP:0001956)1.73160458
105Abnormality of saccadic eye movements (HP:0000570)1.72952106
106Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.72121146
107Short 4th metacarpal (HP:0010044)1.72121146
108Urethral obstruction (HP:0000796)1.72114690
109Onion bulb formation (HP:0003383)1.71118863
110Pulmonic stenosis (HP:0001642)1.70940451
111Epileptiform EEG discharges (HP:0011182)1.70510604
112Abnormality of the labia majora (HP:0012881)1.69982921
113EEG with generalized epileptiform discharges (HP:0011198)1.69533569
114Osteolytic defects of the phalanges of the hand (HP:0009771)1.69212493
115Osteolytic defects of the hand bones (HP:0009699)1.69212493
116Renal duplication (HP:0000075)1.69047639
117Flat cornea (HP:0007720)1.67348614
118Bronchomalacia (HP:0002780)1.67241123
119Aplasia of the phalanges of the hand (HP:0009802)1.67177278
120Aplasia involving bones of the extremities (HP:0009825)1.67177278
121Aplasia involving bones of the upper limbs (HP:0009823)1.67177278
122Abnormality of salivation (HP:0100755)1.66804210
123Blue irides (HP:0000635)1.65981878
124Bradykinesia (HP:0002067)1.65918219
125Megalencephaly (HP:0001355)1.65881308
126Midline defect of the nose (HP:0004122)1.65763651
127Broad metatarsal (HP:0001783)1.65265103
128Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.65251637
129Clonus (HP:0002169)1.64965696
130Pheochromocytoma (HP:0002666)1.64825218
131Atrophic scars (HP:0001075)1.62599603
132Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.62126352
133Degeneration of the lateral corticospinal tracts (HP:0002314)1.62126352
134Prolonged QT interval (HP:0001657)1.61908457
135Cubitus valgus (HP:0002967)1.61763768
136Postural tremor (HP:0002174)1.60736305
137Widely spaced teeth (HP:0000687)1.59926235
138Obstructive sleep apnea (HP:0002870)1.59841324
139Thickened helices (HP:0000391)1.59523608
140Hypsarrhythmia (HP:0002521)1.59101012
141Impaired vibratory sensation (HP:0002495)1.58550963
142Polyphagia (HP:0002591)1.58504862
143Heterotopia (HP:0002282)1.58199011
144Cutaneous finger syndactyly (HP:0010554)1.57908789
145Open mouth (HP:0000194)1.56844908
146Difficulty running (HP:0009046)1.56235046
147Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.54990511
148Large earlobe (HP:0009748)1.54215025
149Neonatal hypoglycemia (HP:0001998)1.54036365
150Vitreoretinal degeneration (HP:0000655)1.52852562
151Broad face (HP:0000283)1.52589196
152Spontaneous hematomas (HP:0007420)1.50524347
153Round face (HP:0000311)1.48922135
154Limited hip movement (HP:0008800)1.48013452
155Mild short stature (HP:0003502)1.47050500
156Short metatarsal (HP:0010743)1.46836434
157Short chin (HP:0000331)1.45364961
158Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.45167379
159Tracheomalacia (HP:0002779)1.44215026

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.46234323
2MAP3K93.22036484
3AKT32.94484024
4MARK12.93888196
5EPHA42.54358970
6DAPK22.50971460
7MAP3K42.50274352
8CAMK1G2.37765591
9PAK62.17361821
10RIPK12.13340446
11MINK12.11744717
12FRK2.10568165
13NTRK21.98480247
14CAMK1D1.89230728
15SIK21.88593506
16CAMKK11.85126481
17STK381.76475857
18NTRK11.76366196
19PRKD31.72034862
20MAP2K41.69269888
21MAP3K61.50472770
22KSR21.42605150
23MAP2K71.41249793
24SGK31.39611721
25RIPK41.39484879
26SGK21.39284893
27SGK4941.35046809
28SGK2231.35046809
29CDK51.32432088
30CAMKK21.31227451
31PHKG11.29170335
32PHKG21.29170335
33FGFR31.26002636
34WNK11.24433727
35KSR11.24336072
36ICK1.18933011
37EPHA31.17085760
38YES11.13743162
39PNCK1.09443865
40LMTK21.08949391
41MAPK131.05495057
42MET1.03543273
43TYRO31.03312681
44PRKCH1.02573567
45LATS20.96458302
46FGR0.95183621
47BLK0.94271907
48FGFR20.93397465
49SGK10.92596418
50STK38L0.92267427
51MAP3K20.91836755
52PDGFRA0.91342406
53MARK20.90490638
54PLK20.90223540
55TGFBR20.89385979
56RET0.88966884
57JAK10.87094968
58PRKCG0.85951231
59STK110.85339574
60CDC42BPA0.83516928
61TAOK10.79907041
62DMPK0.79754022
63FES0.78708620
64NLK0.77717970
65PAK30.77624259
66NEK90.77034796
67OXSR10.76601297
68DAPK10.75784358
69CAMK10.75092605
70GRK50.75039931
71NEK60.74841871
72EPHB10.74376925
73CAMK40.73674829
74INSRR0.73599847
75PTK2B0.73512588
76ACVR1B0.71695731
77DDR20.71524342
78PIK3CA0.71092775
79TRPM70.70823656
80SCYL20.68306409
81ROCK20.67786998
82PRPF4B0.67432714
83CAMK2A0.66427983
84JAK20.66230497
85ERBB20.65441387
86RAF10.65296582
87UHMK10.65239782
88PIK3CG0.64600315
89RPS6KA20.64310886
90IRAK20.63894976
91SIK10.63850849
92FER0.62761713
93RPS6KA30.62616448
94PDGFRB0.62469217
95MAPK100.62102768
96IRAK10.62046633
97TNIK0.61493320
98PTK20.61403583
99PRKAA20.61328043
100PDPK10.61175185
101MAP3K70.60988702
102MAPK70.60342019
103TTN0.59603168
104FYN0.59298397
105CDK150.59262933
106CDK180.59118431
107PKN10.59109332
108MELK0.57809290
109ROCK10.57567253
110PDK10.57206594
111CSK0.56929716
112MAP3K130.56797277
113CASK0.56436157
114ERBB30.56391351
115STK390.56007092
116WNK30.55355419
117PRKCZ0.55217305
118MAP3K10.54796746
119BRD40.54541797
120ALK0.54489240
121PRKAA10.53034472
122CSNK1G20.52604213
123LATS10.52052082
124DYRK1A0.51802415
125PTK60.51393533
126CDK140.49833307
127CDK120.49487499
128FGFR10.49430330
129OBSCN0.49383780
130MAP2K30.49312789
131PDK40.48442753
132PDK30.48442753
133MAPK120.48388574
134MTOR0.48350558
135PKN20.46831761
136RPS6KB10.46589275
137CAMK2B0.46208062

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.61570165
2Synaptic vesicle cycle_Homo sapiens_hsa047212.48027208
3Circadian entrainment_Homo sapiens_hsa047132.17266849
4GABAergic synapse_Homo sapiens_hsa047272.10171834
5Olfactory transduction_Homo sapiens_hsa047402.07709660
6Glutamatergic synapse_Homo sapiens_hsa047242.06215887
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.98670706
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.97983889
9Long-term potentiation_Homo sapiens_hsa047201.89796405
10Morphine addiction_Homo sapiens_hsa050321.87397174
11Nitrogen metabolism_Homo sapiens_hsa009101.81835546
12Salivary secretion_Homo sapiens_hsa049701.80371836
13Insulin secretion_Homo sapiens_hsa049111.68685271
14Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63013811
15Gastric acid secretion_Homo sapiens_hsa049711.60627616
16Amphetamine addiction_Homo sapiens_hsa050311.60559791
17Type II diabetes mellitus_Homo sapiens_hsa049301.59507005
18Dopaminergic synapse_Homo sapiens_hsa047281.59312196
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.58468851
20Cholinergic synapse_Homo sapiens_hsa047251.56259015
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53369278
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49673771
23Renin secretion_Homo sapiens_hsa049241.45208683
24Phototransduction_Homo sapiens_hsa047441.38014304
25Adherens junction_Homo sapiens_hsa045201.34715087
26Oxytocin signaling pathway_Homo sapiens_hsa049211.33533604
27Taste transduction_Homo sapiens_hsa047421.31726011
28Long-term depression_Homo sapiens_hsa047301.29267662
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28208241
30GnRH signaling pathway_Homo sapiens_hsa049121.26055675
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23861931
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21889672
33Cocaine addiction_Homo sapiens_hsa050301.20686187
34Calcium signaling pathway_Homo sapiens_hsa040201.20355214
35cAMP signaling pathway_Homo sapiens_hsa040241.19508461
36Axon guidance_Homo sapiens_hsa043601.16559653
37Dorso-ventral axis formation_Homo sapiens_hsa043201.15285536
38Gap junction_Homo sapiens_hsa045401.12972194
39ECM-receptor interaction_Homo sapiens_hsa045121.12828576
40Estrogen signaling pathway_Homo sapiens_hsa049151.12236634
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10935426
42Glioma_Homo sapiens_hsa052141.10344283
43Serotonergic synapse_Homo sapiens_hsa047261.10328212
44Dilated cardiomyopathy_Homo sapiens_hsa054141.05364143
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05004437
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04050158
47Prolactin signaling pathway_Homo sapiens_hsa049171.02775985
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02113046
49Bile secretion_Homo sapiens_hsa049761.00922667
50Platelet activation_Homo sapiens_hsa046110.95032674
51ErbB signaling pathway_Homo sapiens_hsa040120.94734602
52FoxO signaling pathway_Homo sapiens_hsa040680.93925692
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93337982
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.92560388
55Chronic myeloid leukemia_Homo sapiens_hsa052200.91934469
56MicroRNAs in cancer_Homo sapiens_hsa052060.88344602
57Melanogenesis_Homo sapiens_hsa049160.85915103
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83948869
59Prostate cancer_Homo sapiens_hsa052150.83896853
60Osteoclast differentiation_Homo sapiens_hsa043800.83285837
61Pancreatic cancer_Homo sapiens_hsa052120.82997420
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82098381
63Tight junction_Homo sapiens_hsa045300.82003978
64Collecting duct acid secretion_Homo sapiens_hsa049660.81560112
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80800200
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80723911
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.79571683
68Thyroid hormone synthesis_Homo sapiens_hsa049180.78282294
69Notch signaling pathway_Homo sapiens_hsa043300.77124378
70Pancreatic secretion_Homo sapiens_hsa049720.77020528
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.76721338
72Choline metabolism in cancer_Homo sapiens_hsa052310.75843305
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.75703151
74mTOR signaling pathway_Homo sapiens_hsa041500.75228539
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74963573
76Colorectal cancer_Homo sapiens_hsa052100.74646131
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73567410
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73277364
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72128124
80Inositol phosphate metabolism_Homo sapiens_hsa005620.68203126
81Hippo signaling pathway_Homo sapiens_hsa043900.67832527
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67610588
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67446874
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65888671
85Glucagon signaling pathway_Homo sapiens_hsa049220.65725938
86MAPK signaling pathway_Homo sapiens_hsa040100.64780056
87Melanoma_Homo sapiens_hsa052180.64161588
88TGF-beta signaling pathway_Homo sapiens_hsa043500.63397936
89Rap1 signaling pathway_Homo sapiens_hsa040150.63151540
90Endometrial cancer_Homo sapiens_hsa052130.62441880
91Pathways in cancer_Homo sapiens_hsa052000.59958343
92Lysine degradation_Homo sapiens_hsa003100.59153445
93Endocytosis_Homo sapiens_hsa041440.59048570
94Insulin signaling pathway_Homo sapiens_hsa049100.58660398
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58123345
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55566362
97Ovarian steroidogenesis_Homo sapiens_hsa049130.55355850
98Arginine biosynthesis_Homo sapiens_hsa002200.54191960
99Renal cell carcinoma_Homo sapiens_hsa052110.53148143
100Oocyte meiosis_Homo sapiens_hsa041140.52256095
101VEGF signaling pathway_Homo sapiens_hsa043700.51131110
102Ras signaling pathway_Homo sapiens_hsa040140.50613861
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49593102
104Proteoglycans in cancer_Homo sapiens_hsa052050.48759269
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48732774
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48435322
107Insulin resistance_Homo sapiens_hsa049310.47268841
108Non-small cell lung cancer_Homo sapiens_hsa052230.46974752
109Fatty acid biosynthesis_Homo sapiens_hsa000610.46728016
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.46724683
111Focal adhesion_Homo sapiens_hsa045100.45698390
112Circadian rhythm_Homo sapiens_hsa047100.44715942
113Prion diseases_Homo sapiens_hsa050200.44294053
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44177557
115Amoebiasis_Homo sapiens_hsa051460.43863365
116AMPK signaling pathway_Homo sapiens_hsa041520.42146765
117Butanoate metabolism_Homo sapiens_hsa006500.40591048
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40156084
119Vibrio cholerae infection_Homo sapiens_hsa051100.38303046
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37457141
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37168985
122ABC transporters_Homo sapiens_hsa020100.36832466
123Wnt signaling pathway_Homo sapiens_hsa043100.36571727
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36483839

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