WDFY4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)6.88800658
2positive regulation of gamma-delta T cell activation (GO:0046645)6.30593963
3positive regulation of B cell differentiation (GO:0045579)6.16224138
4antigen processing and presentation of endogenous antigen (GO:0019883)5.67383489
5regulation of B cell differentiation (GO:0045577)5.35220820
6regulation of B cell receptor signaling pathway (GO:0050855)5.20061150
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.07710574
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.07710574
9regulation of interferon-beta biosynthetic process (GO:0045357)4.57883362
10regulation of gamma-delta T cell differentiation (GO:0045586)4.57467340
11regulation of gamma-delta T cell activation (GO:0046643)4.34116627
12negative regulation of phagocytosis (GO:0050765)4.33586698
13response to peptidoglycan (GO:0032494)4.33378969
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.22338494
15positive regulation by organism of defense response of other organism involved in symbiotic interact4.22338494
16modulation by symbiont of host immune response (GO:0052553)4.22338494
17positive regulation by symbiont of host defense response (GO:0052509)4.22338494
18modulation by symbiont of host defense response (GO:0052031)4.22338494
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.22338494
20detection of other organism (GO:0098543)4.22008869
21detection of bacterium (GO:0016045)4.14117217
22negative thymic T cell selection (GO:0045060)4.04950193
23regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.97952959
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.95426081
25positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.89700268
26cellular extravasation (GO:0045123)3.81623342
27negative regulation of B cell proliferation (GO:0030889)3.76511917
28immunoglobulin mediated immune response (GO:0016064)3.75358853
29negative T cell selection (GO:0043383)3.75279679
30regulation of histone H3-K9 methylation (GO:0051570)3.74450845
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.74350709
32regulation of dendritic cell antigen processing and presentation (GO:0002604)3.70853424
33macrophage activation involved in immune response (GO:0002281)3.67279388
34detection of external biotic stimulus (GO:0098581)3.66615163
35regulation of antigen processing and presentation (GO:0002577)3.66245001
36B cell proliferation (GO:0042100)3.66108192
37mature B cell differentiation (GO:0002335)3.65111985
38positive regulation of mast cell activation (GO:0033005)3.64199362
39negative regulation of interleukin-12 production (GO:0032695)3.60502611
40negative regulation of granulocyte differentiation (GO:0030853)3.57494742
41cellular response to zinc ion (GO:0071294)3.57482910
42positive thymic T cell selection (GO:0045059)3.56639859
43B cell homeostasis (GO:0001782)3.54438702
44detection of molecule of bacterial origin (GO:0032490)3.54000229
45natural killer cell differentiation (GO:0001779)3.53037391
46neutrophil activation involved in immune response (GO:0002283)3.50061105
47T cell homeostasis (GO:0043029)3.49655305
48positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.49543052
49respiratory burst (GO:0045730)3.46787490
50lymphocyte homeostasis (GO:0002260)3.43431758
51positive regulation of histone deacetylation (GO:0031065)3.41287265
52negative regulation of histone methylation (GO:0031061)3.40606218
53T-helper 1 type immune response (GO:0042088)3.39973633
54negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.38750790
55negative regulation of cell killing (GO:0031342)3.38750790
56positive regulation of interferon-alpha production (GO:0032727)3.36888967
57neutrophil activation (GO:0042119)3.35958103
58negative regulation of T cell mediated immunity (GO:0002710)3.35755227
59T cell selection (GO:0045058)3.34966946
60thymic T cell selection (GO:0045061)3.33949043
61microglial cell activation (GO:0001774)3.30598457
62CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.27687070
63negative regulation of bone resorption (GO:0045779)3.27225084
64regulation of mast cell activation (GO:0033003)3.25276269
65defense response to protozoan (GO:0042832)3.25164868
66positive T cell selection (GO:0043368)3.25111361
67negative regulation of lymphocyte mediated immunity (GO:0002707)3.22442209
68detection of biotic stimulus (GO:0009595)3.20823672
69type I interferon signaling pathway (GO:0060337)3.20475857
70cellular response to type I interferon (GO:0071357)3.20475857
71regulation of interleukin-12 biosynthetic process (GO:0045075)3.19929018
72regulation of B cell proliferation (GO:0030888)3.19708213
73antigen receptor-mediated signaling pathway (GO:0050851)3.19155385
74response to type I interferon (GO:0034340)3.18875910
75regulation of interferon-alpha production (GO:0032647)3.18700917
76positive regulation of type 2 immune response (GO:0002830)3.17903729
77positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.16453365
78regulation of superoxide anion generation (GO:0032928)3.16405166
79regulation of myeloid leukocyte mediated immunity (GO:0002886)3.16152647
80regulation of mast cell activation involved in immune response (GO:0033006)3.16121907
81regulation of T-helper 2 cell differentiation (GO:0045628)3.14751123
82response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.14232161
83response to host (GO:0075136)3.14232161
84response to host defenses (GO:0052200)3.14232161
85regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.14200915
86cellular response to ethanol (GO:0071361)3.12327124
87macrophage activation (GO:0042116)3.11576560
88regulation of B cell apoptotic process (GO:0002902)3.09915974
89granulocyte activation (GO:0036230)3.06519400
90positive regulation of cellular amide metabolic process (GO:0034250)3.05683636
91positive regulation of B cell proliferation (GO:0030890)3.05659376
92leukocyte homeostasis (GO:0001776)3.05110007
93tolerance induction (GO:0002507)3.03061205
94regulation of leukocyte degranulation (GO:0043300)3.02329207
95production of molecular mediator involved in inflammatory response (GO:0002532)3.02135328
96regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.00533610
97regulation of hypersensitivity (GO:0002883)2.99195636
98mature B cell differentiation involved in immune response (GO:0002313)2.98539430
99negative regulation of leukocyte mediated immunity (GO:0002704)2.98100241
100negative regulation of erythrocyte differentiation (GO:0045647)2.97139530
101response to protozoan (GO:0001562)2.96322311
102myeloid cell activation involved in immune response (GO:0002275)2.94689936
103regulation of granulocyte differentiation (GO:0030852)2.92313835
104B cell activation (GO:0042113)2.91350030
105T cell migration (GO:0072678)2.90421471
106germinal center formation (GO:0002467)2.89301716
107positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.88527447
108hepatocyte apoptotic process (GO:0097284)2.88227108
109positive regulation of B cell activation (GO:0050871)2.88154788
110serine transport (GO:0032329)2.87747843
111mononuclear cell proliferation (GO:0032943)2.87563434
112pinocytosis (GO:0006907)2.87450369
113regulation of alpha-beta T cell proliferation (GO:0046640)2.86265098
114regulation of T-helper 1 cell differentiation (GO:0045625)2.85370439
115positive regulation of granulocyte differentiation (GO:0030854)2.82815467
116immune response-activating cell surface receptor signaling pathway (GO:0002429)2.80344396
117mast cell degranulation (GO:0043303)2.80055159
118mast cell activation involved in immune response (GO:0002279)2.80055159
119DNA unwinding involved in DNA replication (GO:0006268)2.79595246
120lymphocyte proliferation (GO:0046651)2.79310671
121B cell mediated immunity (GO:0019724)2.78873396
122myeloid dendritic cell activation (GO:0001773)2.78810842
123natural killer cell mediated immunity (GO:0002228)2.78298035
124natural killer cell mediated cytotoxicity (GO:0042267)2.78298035
125adaptation of signaling pathway (GO:0023058)2.76661451
126B cell differentiation (GO:0030183)2.75835778
127V(D)J recombination (GO:0033151)2.75564010
128positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.73680066
129positive regulation of protein deacetylation (GO:0090312)2.72504376
130positive regulation of mast cell activation involved in immune response (GO:0033008)2.71069432
131positive regulation of mast cell degranulation (GO:0043306)2.71069432
132Arp2/3 complex-mediated actin nucleation (GO:0034314)2.70637232
133regulation of mast cell degranulation (GO:0043304)2.70020956
134mast cell activation (GO:0045576)2.69555809
135leukocyte aggregation (GO:0070486)2.68780239
136positive regulation of Rap GTPase activity (GO:0032854)2.66530214
137positive regulation by host of viral transcription (GO:0043923)2.66406936
138interferon-gamma-mediated signaling pathway (GO:0060333)2.65908325
139positive regulation of antigen processing and presentation (GO:0002579)2.65806897
140cellular hyperosmotic response (GO:0071474)2.65731672
141response to muramyl dipeptide (GO:0032495)2.65131866
142response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.64301740
143response to host immune response (GO:0052572)2.64301740
144regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.63079704
145regulation of B cell activation (GO:0050864)2.62689543
146negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.62467794
147determination of adult lifespan (GO:0008340)2.61822259
148NIK/NF-kappaB signaling (GO:0038061)2.61559766

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.53531034
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.05084110
3MYC_22102868_ChIP-Seq_BL_Human4.24036482
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.73972885
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.60261450
6VDR_21846776_ChIP-Seq_THP-1_Human3.51512273
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.49509297
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.40227181
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.38541550
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.34269881
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.15974774
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.02184864
13SCL_19346495_ChIP-Seq_HPC-7_Human2.91799631
14* IRF8_27001747_Chip-Seq_BMDM_Mouse2.88195493
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.69533373
16* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.67904108
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42615524
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.41650908
19VDR_24763502_ChIP-Seq_THP-1_Human2.40580371
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.39310995
21* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.38139204
22MYB_26560356_Chip-Seq_TH2_Human2.30771996
23MAF_26560356_Chip-Seq_TH1_Human2.29561711
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.25416779
25MYB_26560356_Chip-Seq_TH1_Human2.22674270
26TCF7_22412390_ChIP-Seq_EML_Mouse2.22299590
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.21314481
28RUNX_20019798_ChIP-Seq_JUKART_Human2.19565801
29UTX_26944678_Chip-Seq_JUKART_Human2.17618787
30SPI1_23547873_ChIP-Seq_NB4_Human2.17335171
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.10654856
32* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.07915327
33E2F4_17652178_ChIP-ChIP_JURKAT_Human2.05880166
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.93677683
35CIITA_25753668_ChIP-Seq_RAJI_Human1.91410716
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.91242995
37* SPI1_23127762_ChIP-Seq_K562_Human1.91240116
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.90237914
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.81987654
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.80745338
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.76267969
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74615833
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70792515
44KDM2B_26808549_Chip-Seq_DND41_Human1.64301825
45* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60763379
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59649057
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57571894
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.53364403
49GATA1_22025678_ChIP-Seq_K562_Human1.51768506
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.51489160
51NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.49539071
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.49342807
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48195611
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.45687377
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43877818
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41653635
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41079352
58MAF_26560356_Chip-Seq_TH2_Human1.40837033
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.35845903
60GATA3_27048872_Chip-Seq_THYMUS_Human1.33665522
61EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.32266273
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31092860
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30408508
64PU_27001747_Chip-Seq_BMDM_Mouse1.29761603
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25293031
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22589553
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22523484
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.22446697
69PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21626739
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21462130
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20000289
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18337376
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18021452
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16998459
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16547386
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16181573
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15363822
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.13604651
79LXR_22292898_ChIP-Seq_THP-1_Human1.13041749
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12117628
81CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10093568
82GATA1_19941827_ChIP-Seq_MEL_Mouse1.09828563
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09025140
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06086644
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06023807
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05094824
87PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99810112
88ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99455041
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94753091
90GATA2_19941826_ChIP-Seq_K562_Human0.92751508
91FOXP3_21729870_ChIP-Seq_TREG_Human0.92429219
92TFEB_21752829_ChIP-Seq_HELA_Human0.92424423
93NCOR1_26117541_ChIP-Seq_K562_Human0.91522907
94KDM5A_27292631_Chip-Seq_BREAST_Human0.91230963
95GATA3_26560356_Chip-Seq_TH2_Human0.89588310
96SMRT_27268052_Chip-Seq_Bcells_Human0.88070066
97CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86051644
98BCL6_27268052_Chip-Seq_Bcells_Human0.85481710
99VDR_24787735_ChIP-Seq_THP-1_Human0.85170741
100KDM2B_26808549_Chip-Seq_JURKAT_Human0.83001412
101ETS1_22383799_ChIP-Seq_G1ME_Mouse0.82155949
102RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81770890
103VDR_23849224_ChIP-Seq_CD4+_Human0.80748839
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79164035
105NOTCH1_21737748_ChIP-Seq_TLL_Human0.78758593
106BCOR_27268052_Chip-Seq_Bcells_Human0.78506932
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.77824554
108KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.77257639
109RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76869386
110SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76709132
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75934820
112STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.75415587
113GATA2_21666600_ChIP-Seq_HMVEC_Human0.75054698
114GATA1_19941826_ChIP-Seq_K562_Human0.74839086
115TP63_19390658_ChIP-ChIP_HaCaT_Human0.74807035
116GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.74681809
117P300_27268052_Chip-Seq_Bcells_Human0.73299001
118LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.73167924

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.63689847
2MP0001800_abnormal_humoral_immune3.81648031
3MP0005387_immune_system_phenotype3.52225462
4MP0001790_abnormal_immune_system3.52225462
5MP0003303_peritoneal_inflammation3.34263222
6MP0000685_abnormal_immune_system3.30793332
7MP0002452_abnormal_antigen_presenting3.16339522
8MP0002396_abnormal_hematopoietic_system3.10401344
9MP0005000_abnormal_immune_tolerance2.72457182
10MP0002723_abnormal_immune_serum2.70049673
11MP0002420_abnormal_adaptive_immunity2.67223220
12MP0002398_abnormal_bone_marrow2.66214771
13MP0001819_abnormal_immune_cell2.62782742
14MP0000569_abnormal_digit_pigmentation2.56958279
15MP0003436_decreased_susceptibility_to2.47357958
16MP0005671_abnormal_response_to2.42986209
17MP0000689_abnormal_spleen_morphology2.42922676
18MP0004808_abnormal_hematopoietic_stem2.38460933
19MP0000716_abnormal_immune_system2.36578484
20MP0003300_gastrointestinal_ulcer2.36280963
21MP0009278_abnormal_bone_marrow2.36087312
22MP0002419_abnormal_innate_immunity2.28267102
23MP0002166_altered_tumor_susceptibility2.26051303
24MP0005025_abnormal_response_to2.20867543
25MP0002722_abnormal_immune_system2.13487897
26MP0005464_abnormal_platelet_physiology2.12189387
27MP0009785_altered_susceptibility_to2.04585820
28MP0002429_abnormal_blood_cell1.99991027
29MP0005174_abnormal_tail_pigmentation1.87529221
30MP0003763_abnormal_thymus_physiology1.80107982
31MP0001873_stomach_inflammation1.77883658
32MP0005451_abnormal_body_composition1.77787250
33MP0002405_respiratory_system_inflammati1.77616116
34MP0003183_abnormal_peptide_metabolism1.76665903
35MP0000703_abnormal_thymus_morphology1.75331170
36MP0001545_abnormal_hematopoietic_system1.66580537
37MP0005397_hematopoietic_system_phenotyp1.66580537
38MP0008057_abnormal_DNA_replication1.66280015
39MP0002148_abnormal_hypersensitivity_rea1.66102428
40MP0010155_abnormal_intestine_physiology1.59609663
41MP0004947_skin_inflammation1.59526643
42MP0002006_tumorigenesis1.56846553
43MP0003172_abnormal_lysosome_physiology1.55495287
44MP0000465_gastrointestinal_hemorrhage1.55391653
45MP0001845_abnormal_inflammatory_respons1.53279303
46MP0010094_abnormal_chromosome_stability1.51763013
47MP0001853_heart_inflammation1.51411862
48MP0008260_abnormal_autophagy1.48191672
49MP0010307_abnormal_tumor_latency1.46764330
50MP0004510_myositis1.36559837
51MP0010352_gastrointestinal_tract_polyps1.36547537
52MP0009333_abnormal_splenocyte_physiolog1.32997293
53MP0003077_abnormal_cell_cycle1.29244830
54MP0005058_abnormal_lysosome_morphology1.27566642
55MP0002998_abnormal_bone_remodeling1.26785866
56MP0004381_abnormal_hair_follicle1.24844456
57MP0000490_abnormal_crypts_of1.24408957
58MP0003111_abnormal_nucleus_morphology1.22043405
59MP0002019_abnormal_tumor_incidence1.22011975
60MP0005076_abnormal_cell_differentiation1.21628122
61MP0003866_abnormal_defecation1.18935448
62MP0006082_CNS_inflammation1.18720911
63MP0000015_abnormal_ear_pigmentation1.17632163
64MP0003075_altered_response_to1.16242525
65MP0000604_amyloidosis1.16098175
66MP0000343_altered_response_to1.09734038
67MP0008004_abnormal_stomach_pH1.09430176
68MP0003693_abnormal_embryo_hatching1.09223351
69MP0005310_abnormal_salivary_gland1.08909729
70MP0003191_abnormal_cellular_cholesterol1.07649061
71MP0006054_spinal_hemorrhage1.05784265
72MP0009764_decreased_sensitivity_to1.02776713
73MP0003566_abnormal_cell_adhesion1.02579342
74MP0008469_abnormal_protein_level1.01807813
75MP0002095_abnormal_skin_pigmentation0.98733903
76MP0001533_abnormal_skeleton_physiology0.98704909
77MP0001986_abnormal_taste_sensitivity0.98440010
78MP0002933_joint_inflammation0.98069110
79MP0003690_abnormal_glial_cell0.92900488
80MP0004883_abnormal_blood_vessel0.90946045
81MP0002009_preneoplasia0.86876843
82MP0005075_abnormal_melanosome_morpholog0.85955901
83MP0001879_abnormal_lymphatic_vessel0.85948349
84MP0003091_abnormal_cell_migration0.81389850
85MP0002928_abnormal_bile_duct0.80435132
86MP0008961_abnormal_basal_metabolism0.78263372
87MP0000350_abnormal_cell_proliferation0.77483852
88MP0002132_abnormal_respiratory_system0.76510137
89MP0009840_abnormal_foam_cell0.76125450
90MP0003448_altered_tumor_morphology0.74989415
91MP0000313_abnormal_cell_death0.74334867
92MP0009115_abnormal_fat_cell0.73751852
93MP0005621_abnormal_cell_physiology0.72546016
94MP0001915_intracranial_hemorrhage0.70881089
95MP0008058_abnormal_DNA_repair0.70506387
96MP0002136_abnormal_kidney_physiology0.67437938
97MP0000858_altered_metastatic_potential0.65865833
98MP0003828_pulmonary_edema0.65625981
99MP0000371_diluted_coat_color0.65345979
100MP0005166_decreased_susceptibility_to0.63268634
101MP0001851_eye_inflammation0.62402743
102MP0001663_abnormal_digestive_system0.61768817
103MP0008007_abnormal_cellular_replicative0.61376329
104MP0001958_emphysema0.60343335
105MP0003943_abnormal_hepatobiliary_system0.58903273
106MP0000249_abnormal_blood_vessel0.57068899
107MP0004957_abnormal_blastocyst_morpholog0.57012859
108MP0001730_embryonic_growth_arrest0.56950730
109MP0009765_abnormal_xenobiotic_induced0.55703896
110MP0005647_abnormal_sex_gland0.55384843
111MP0009763_increased_sensitivity_to0.55028676
112MP0003045_fibrosis0.54918784
113MP0005164_abnormal_response_to0.54357370
114MP0008874_decreased_physiological_sensi0.53919845
115MP0003656_abnormal_erythrocyte_physiolo0.53792824
116MP0003453_abnormal_keratinocyte_physiol0.52351856
117MP0003795_abnormal_bone_structure0.52215914
118MP0003787_abnormal_imprinting0.51945283
119MP0005384_cellular_phenotype0.51913229
120MP0000920_abnormal_myelination0.51319834
121MP0002138_abnormal_hepatobiliary_system0.51286760
122MP0003724_increased_susceptibility_to0.51271963

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)7.77329674
2Cellulitis (HP:0100658)6.64566970
3Verrucae (HP:0200043)5.36428877
4Papilloma (HP:0012740)5.36428877
5Colitis (HP:0002583)4.95044356
6Recurrent viral infections (HP:0004429)4.78506419
7Recurrent bronchitis (HP:0002837)4.66732427
8IgM deficiency (HP:0002850)4.50413389
9Meningitis (HP:0001287)4.50000337
10Inflammation of the large intestine (HP:0002037)4.42838148
11Recurrent abscess formation (HP:0002722)4.36961117
12Gastrointestinal inflammation (HP:0004386)4.35524124
13Recurrent bacterial skin infections (HP:0005406)4.25836911
14Panhypogammaglobulinemia (HP:0003139)4.24882013
15Osteomyelitis (HP:0002754)4.19091954
16Gastrointestinal stroma tumor (HP:0100723)4.13958116
17Thyroiditis (HP:0100646)4.08644516
18B lymphocytopenia (HP:0010976)3.92827136
19Abnormality of B cell number (HP:0010975)3.92827136
20Vacuolated lymphocytes (HP:0001922)3.84744682
21Recurrent fungal infections (HP:0002841)3.80875315
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.76461144
23Chronic otitis media (HP:0000389)3.70308428
24Recurrent sinusitis (HP:0011108)3.58268096
25Chronic sinusitis (HP:0011109)3.55950685
26Abnormality of the fingertips (HP:0001211)3.53216293
27Small epiphyses (HP:0010585)3.44725534
28Recurrent pneumonia (HP:0006532)3.42958833
29Sepsis (HP:0100806)3.31946378
30Lymphopenia (HP:0001888)3.22801168
31Chronic mucocutaneous candidiasis (HP:0002728)3.14324375
32Recurrent cutaneous fungal infections (HP:0011370)3.14324375
33Recurrent skin infections (HP:0001581)3.13578489
34Recurrent lower respiratory tract infections (HP:0002783)3.11717432
35Abnormality of cells of the lymphoid lineage (HP:0012140)3.11005445
36Eczematoid dermatitis (HP:0000976)3.07043112
37Systemic lupus erythematosus (HP:0002725)3.05091065
38Vasculitis (HP:0002633)3.02937772
39Abnormality of liposaccharide metabolism (HP:0010968)3.02235157
40Abnormality of glycosphingolipid metabolism (HP:0004343)3.02235157
41Abnormality of glycolipid metabolism (HP:0010969)3.02235157
42Optic neuritis (HP:0100653)3.01542606
43Retrobulbar optic neuritis (HP:0100654)3.01542606
44Orchitis (HP:0100796)2.96681670
45Autoimmune thrombocytopenia (HP:0001973)2.93407574
46Mediastinal lymphadenopathy (HP:0100721)2.84068774
47Mitral stenosis (HP:0001718)2.80716762
48Pulmonary infiltrates (HP:0002113)2.80439364
49Emphysema (HP:0002097)2.79922130
50Gastrointestinal infarctions (HP:0005244)2.78178210
51Urticaria (HP:0001025)2.77901210
52Hemoptysis (HP:0002105)2.71143284
53Recurrent otitis media (HP:0000403)2.63970374
54Vertebral arch anomaly (HP:0008438)2.63423724
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.62002713
56Abnormality of the intervertebral disk (HP:0005108)2.59223678
57Obstructive lung disease (HP:0006536)2.59203846
58Chronic obstructive pulmonary disease (HP:0006510)2.59203846
59Thrombocytosis (HP:0001894)2.58650307
60Spontaneous hematomas (HP:0007420)2.56080927
61Bronchitis (HP:0012387)2.54918834
62Hypoplasia of the capital femoral epiphysis (HP:0003090)2.54099343
63Stomatitis (HP:0010280)2.51738434
64Restrictive lung disease (HP:0002091)2.51663459
65T lymphocytopenia (HP:0005403)2.50686019
66Abnormality of T cells (HP:0002843)2.48321154
67IgA deficiency (HP:0002720)2.46734426
68Hematochezia (HP:0002573)2.46604646
69Periodontitis (HP:0000704)2.45685742
70Abnormality of the prostate (HP:0008775)2.45293593
71Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.44454504
72Abnormality of T cell physiology (HP:0011840)2.42314210
73Prolonged bleeding time (HP:0003010)2.41369805
74Recurrent gram-negative bacterial infections (HP:0005420)2.39221797
75Abnormality of T cell number (HP:0011839)2.33599163
76Ulnar bowing (HP:0003031)2.32570951
77Interstitial pulmonary disease (HP:0006530)2.32207915
78Skin rash (HP:0000988)2.29779583
79Abnormality of the peritoneum (HP:0002585)2.28413559
80Skin ulcer (HP:0200042)2.26384456
81Chronic diarrhea (HP:0002028)2.25555817
82Loss of speech (HP:0002371)2.24567581
83Lymphoma (HP:0002665)2.24194469
84Dysostosis multiplex (HP:0000943)2.23560789
85Flattened epiphyses (HP:0003071)2.22591009
86Leukopenia (HP:0001882)2.18521357
87Keratoconjunctivitis sicca (HP:0001097)2.17524397
88Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.17178958
89Abnormality of the pleura (HP:0002103)2.15979625
90Pustule (HP:0200039)2.14157641
91Eosinophilia (HP:0001880)2.12887703
92IgG deficiency (HP:0004315)2.12579389
93Hypoplasia of the thymus (HP:0000778)2.11424964
94Increased IgE level (HP:0003212)2.09952434
95Viral hepatitis (HP:0006562)2.09160254
96Nasal polyposis (HP:0100582)2.07349773
97Combined immunodeficiency (HP:0005387)2.04458703
98Amaurosis fugax (HP:0100576)2.03484917
99Severe combined immunodeficiency (HP:0004430)2.02836848
100Increased IgM level (HP:0003496)2.00609683
101Long eyelashes (HP:0000527)2.00541538
102Pulmonary embolism (HP:0002204)1.98513150
103Autoimmune hemolytic anemia (HP:0001890)1.98020287
104Keratoconjunctivitis (HP:0001096)1.97827078
105Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.96413905
106Absent epiphyses (HP:0010577)1.96413905
107Fatigue (HP:0012378)1.96217583
108Encephalitis (HP:0002383)1.94921329
109Arthralgia (HP:0002829)1.93318173
110Premature loss of primary teeth (HP:0006323)1.92860161
111Arthropathy (HP:0003040)1.92374972
112Myositis (HP:0100614)1.91788968
113Slow saccadic eye movements (HP:0000514)1.91534390
114Gingivitis (HP:0000230)1.91438740
115Abnormality of macrophages (HP:0004311)1.90483364
116Neutropenia (HP:0001875)1.89685552
117Acute lymphatic leukemia (HP:0006721)1.88142102
118Elevated erythrocyte sedimentation rate (HP:0003565)1.88127415
119Abnormal platelet function (HP:0011869)1.88013292
120Impaired platelet aggregation (HP:0003540)1.88013292
121Granulocytopenia (HP:0001913)1.87010971
122Increased density of long bones (HP:0006392)1.86639148
123Chest pain (HP:0100749)1.84201047
124Abnormality of the nasal mucosa (HP:0000433)1.82532213
125Gingival bleeding (HP:0000225)1.80421983
126Increased cerebral lipofuscin (HP:0011813)1.80044220
127Leukocytosis (HP:0001974)1.80040542
128Epistaxis (HP:0000421)1.79339988
129Cutaneous melanoma (HP:0012056)1.78760677
130Arterial thrombosis (HP:0004420)1.74917352
131Abnormality of eosinophils (HP:0001879)1.74622663

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K105.35033960
2MAP4K15.06240432
3EEF2K3.73852752
4PRPF4B2.99454174
5ERN12.85362413
6GRK62.71146909
7CSF1R2.68821871
8RIPK42.44093581
9SIK22.31866386
10SYK2.24051704
11BTK2.22233425
12BLK2.21545888
13STK102.08635655
14CDK122.02898258
15KIT1.96958496
16TYK21.93170087
17LRRK21.71166158
18FES1.67234416
19CLK11.60599459
20PKN21.56963662
21MAP3K141.53137460
22NEK21.49760930
23HCK1.48526796
24BMPR21.40930040
25CDC42BPA1.38716884
26NEK91.37723417
27TRIB31.37096990
28MAP3K131.34805799
29JAK11.33102271
30LYN1.28792079
31IRAK41.28655440
32STK41.28187521
33TBK11.26691350
34PIM11.25060915
35JAK31.22678098
36ZAP701.19453464
37PIK3CG1.17328342
38CDK41.16749263
39BRD41.12259148
40TXK1.09887791
41CSK1.09187232
42SMG11.07246450
43TGFBR21.05905031
44IKBKB1.05646452
45TAOK31.02749791
46LCK1.01178270
47TEC0.99172715
48CAMK1D0.98598717
49CAMK1G0.96647669
50RPS6KB20.96147788
51FLT30.93961123
52MAP2K30.91804622
53MARK30.89570973
54ITK0.88280913
55FGFR30.86282237
56TNK20.85091101
57MATK0.84817282
58MAP3K10.83480930
59IKBKE0.82715016
60CDK90.82210883
61HIPK20.81987228
62SCYL20.81783626
63CDC70.81735379
64TLK10.81221822
65KSR20.78678905
66PDPK10.77725054
67IRAK30.76820594
68CDK60.74927146
69GRK70.73367176
70MAP3K110.72779462
71MARK20.71064152
72MAPK120.70098178
73MAPK110.68726776
74PTK60.68586685
75CHUK0.66958203
76RPS6KA40.65478202
77MAPK40.64716555
78MAP3K30.64137662
79IRAK20.64064491
80YES10.63860254
81IRAK10.62795619
82MAP3K80.62567893
83EPHB10.61493022
84TRPM70.60743664
85MAP3K70.58080826
86ALK0.58066073
87TAOK20.57883313
88TAOK10.57564006
89ATR0.55973382
90EIF2AK30.53573680
91SGK20.52087649
92PDK10.51415926
93MAP3K50.50983990
94JAK20.50983417
95TTN0.50060243
96NME20.49086848
97CAMKK10.48699603
98RPS6KL10.48678609
99RPS6KC10.48678609
100MELK0.46697504
101FGR0.45676549
102MAPK70.44681671
103FRK0.43707213
104PRKCQ0.43083562
105MAPKAPK30.42948845
106ABL10.42910218
107FGFR40.41988014
108SGK30.40660843
109MOS0.40533762
110SIK30.38348689
111SIK10.37716784
112PASK0.37238206
113STK30.36516655
114EGFR0.35895178
115CDK190.35706758
116MAPKAPK20.35233042
117TESK20.34014278
118ICK0.33521581
119CAMKK20.33377584
120RPS6KA20.33237760
121MST40.33201164
122PRKCH0.33100254
123STK240.32770082
124CHEK10.32203475
125DYRK1B0.31750488
126RPS6KA60.30910245
127FYN0.29919388
128PRKD10.29137747
129PRKD20.27677356
130MTOR0.27351027

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046624.84519162
2Primary immunodeficiency_Homo sapiens_hsa053404.55380536
3Allograft rejection_Homo sapiens_hsa053303.46340332
4Autoimmune thyroid disease_Homo sapiens_hsa053203.24783698
5Graft-versus-host disease_Homo sapiens_hsa053323.19127767
6Asthma_Homo sapiens_hsa053103.17450472
7Type I diabetes mellitus_Homo sapiens_hsa049402.57826376
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.54159964
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.47405945
10Osteoclast differentiation_Homo sapiens_hsa043802.41487539
11Leishmaniasis_Homo sapiens_hsa051402.24290831
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.09180847
13Hematopoietic cell lineage_Homo sapiens_hsa046402.00828157
14Non-homologous end-joining_Homo sapiens_hsa034501.89830338
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.84272142
16Antigen processing and presentation_Homo sapiens_hsa046121.81865495
17Measles_Homo sapiens_hsa051621.70540507
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.69545307
19DNA replication_Homo sapiens_hsa030301.68112000
20Chronic myeloid leukemia_Homo sapiens_hsa052201.64782607
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.64646369
22Base excision repair_Homo sapiens_hsa034101.62498615
23Rheumatoid arthritis_Homo sapiens_hsa053231.57098154
24Tuberculosis_Homo sapiens_hsa051521.49660392
25Non-small cell lung cancer_Homo sapiens_hsa052231.49550190
26Herpes simplex infection_Homo sapiens_hsa051681.47797192
27Acute myeloid leukemia_Homo sapiens_hsa052211.47105433
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.46246892
29Phagosome_Homo sapiens_hsa041451.40886330
30Chemokine signaling pathway_Homo sapiens_hsa040621.40661977
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.36049652
32T cell receptor signaling pathway_Homo sapiens_hsa046601.32506715
33Mismatch repair_Homo sapiens_hsa034301.32284280
34Hepatitis B_Homo sapiens_hsa051611.31625167
35Influenza A_Homo sapiens_hsa051641.30292778
36Systemic lupus erythematosus_Homo sapiens_hsa053221.29364478
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.28954949
38Platelet activation_Homo sapiens_hsa046111.28386960
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27926121
40Apoptosis_Homo sapiens_hsa042101.27226868
41Toxoplasmosis_Homo sapiens_hsa051451.26010053
42Pancreatic cancer_Homo sapiens_hsa052121.25399518
43Viral carcinogenesis_Homo sapiens_hsa052031.25183435
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21628816
45Epstein-Barr virus infection_Homo sapiens_hsa051691.18912290
46Shigellosis_Homo sapiens_hsa051311.18571607
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.14940793
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14807481
49Neurotrophin signaling pathway_Homo sapiens_hsa047221.08264794
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01443621
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98965145
52Pertussis_Homo sapiens_hsa051330.97261313
53Malaria_Homo sapiens_hsa051440.94956995
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.94500445
55Lysine degradation_Homo sapiens_hsa003100.93050341
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92301678
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91778568
58Staphylococcus aureus infection_Homo sapiens_hsa051500.90392546
59Legionellosis_Homo sapiens_hsa051340.88954573
60Other glycan degradation_Homo sapiens_hsa005110.88922739
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88807429
62Homologous recombination_Homo sapiens_hsa034400.87877363
63Small cell lung cancer_Homo sapiens_hsa052220.86940011
64HTLV-I infection_Homo sapiens_hsa051660.86748209
65Glioma_Homo sapiens_hsa052140.85758678
66TNF signaling pathway_Homo sapiens_hsa046680.85049024
67Cell cycle_Homo sapiens_hsa041100.85010666
68Inositol phosphate metabolism_Homo sapiens_hsa005620.84082985
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82734597
70MicroRNAs in cancer_Homo sapiens_hsa052060.82290567
71VEGF signaling pathway_Homo sapiens_hsa043700.82251816
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82149027
73mTOR signaling pathway_Homo sapiens_hsa041500.80021193
74Hepatitis C_Homo sapiens_hsa051600.75300728
75Viral myocarditis_Homo sapiens_hsa054160.70589499
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69733827
77Salmonella infection_Homo sapiens_hsa051320.69384923
78Colorectal cancer_Homo sapiens_hsa052100.68363248
79Spliceosome_Homo sapiens_hsa030400.65738343
80Fanconi anemia pathway_Homo sapiens_hsa034600.64844108
81FoxO signaling pathway_Homo sapiens_hsa040680.64577660
82Insulin resistance_Homo sapiens_hsa049310.64169254
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62088571
84Lysosome_Homo sapiens_hsa041420.61384133
85African trypanosomiasis_Homo sapiens_hsa051430.59174834
86p53 signaling pathway_Homo sapiens_hsa041150.57698801
87HIF-1 signaling pathway_Homo sapiens_hsa040660.56098850
88Notch signaling pathway_Homo sapiens_hsa043300.55908744
89Type II diabetes mellitus_Homo sapiens_hsa049300.54906978
90Prostate cancer_Homo sapiens_hsa052150.54106902
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53852570
92GnRH signaling pathway_Homo sapiens_hsa049120.52144530
93Prolactin signaling pathway_Homo sapiens_hsa049170.50425880
94Caffeine metabolism_Homo sapiens_hsa002320.48863324
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.48522587
96Ribosome_Homo sapiens_hsa030100.47361739
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46411126
98mRNA surveillance pathway_Homo sapiens_hsa030150.46131039
99Alcoholism_Homo sapiens_hsa050340.45049226
100Endocytosis_Homo sapiens_hsa041440.43539321
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42120308
102Proteoglycans in cancer_Homo sapiens_hsa052050.40861052
103MAPK signaling pathway_Homo sapiens_hsa040100.40261902
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39017061
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38913027
106Renal cell carcinoma_Homo sapiens_hsa052110.38283985
107One carbon pool by folate_Homo sapiens_hsa006700.38183379
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38180343
109Dorso-ventral axis formation_Homo sapiens_hsa043200.37791669
110Nucleotide excision repair_Homo sapiens_hsa034200.36922599
111Renin-angiotensin system_Homo sapiens_hsa046140.36698433
112Choline metabolism in cancer_Homo sapiens_hsa052310.35791025
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.35178121
114Endometrial cancer_Homo sapiens_hsa052130.32119543
115Amoebiasis_Homo sapiens_hsa051460.30545326
116Estrogen signaling pathway_Homo sapiens_hsa049150.29989135
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28866513
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27555180
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.26698254
120ErbB signaling pathway_Homo sapiens_hsa040120.22037402
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19503482
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.18963262
123Long-term potentiation_Homo sapiens_hsa047200.17088919

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