WDR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.97284851
2protein localization to endosome (GO:0036010)4.38233641
3COPI coating of Golgi vesicle (GO:0048205)3.96912174
4Golgi transport vesicle coating (GO:0048200)3.96912174
5regulation of B cell receptor signaling pathway (GO:0050855)3.82045505
6pinocytosis (GO:0006907)3.79531155
7Arp2/3 complex-mediated actin nucleation (GO:0034314)3.66023732
8neutrophil activation involved in immune response (GO:0002283)3.62894841
9synaptic vesicle maturation (GO:0016188)3.61779015
10positive regulation of gamma-delta T cell activation (GO:0046645)3.50611597
11skin morphogenesis (GO:0043589)3.48622327
12locomotory exploration behavior (GO:0035641)3.48103720
13antigen processing and presentation of endogenous antigen (GO:0019883)3.46887792
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.37833548
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.37833548
16positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.29428033
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.29055831
18negative thymic T cell selection (GO:0045060)3.27755051
19hypotonic response (GO:0006971)3.27264962
20barbed-end actin filament capping (GO:0051016)3.15498315
21cell-substrate junction assembly (GO:0007044)3.14912237
22negative T cell selection (GO:0043383)3.12407671
23regulation of synapse structural plasticity (GO:0051823)3.04749781
24cellular response to zinc ion (GO:0071294)3.04108280
25regulation of early endosome to late endosome transport (GO:2000641)3.03314465
26actin nucleation (GO:0045010)3.00692212
27positive regulation of Cdc42 GTPase activity (GO:0043089)3.00528866
28membrane raft organization (GO:0031579)2.97079989
29regulation of dendritic cell antigen processing and presentation (GO:0002604)2.92272003
30negative regulation of erythrocyte differentiation (GO:0045647)2.91847718
31positive regulation of natural killer cell differentiation (GO:0032825)2.89312178
32adherens junction assembly (GO:0034333)2.88245201
33negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.87957043
34negative regulation of cell killing (GO:0031342)2.87957043
35focal adhesion assembly (GO:0048041)2.87031157
36cell-substrate adherens junction assembly (GO:0007045)2.87031157
37positive regulation of blood vessel endothelial cell migration (GO:0043536)2.86239069
38response to laminar fluid shear stress (GO:0034616)2.84583825
39interferon-gamma-mediated signaling pathway (GO:0060333)2.83733623
40signal complex assembly (GO:0007172)2.82932056
41platelet aggregation (GO:0070527)2.81367730
42regulation of interleukin-12 biosynthetic process (GO:0045075)2.80223033
43positive regulation of interferon-alpha production (GO:0032727)2.79748180
44NIK/NF-kappaB signaling (GO:0038061)2.78296655
45endodermal cell differentiation (GO:0035987)2.74831667
46vocalization behavior (GO:0071625)2.70353880
47leukocyte aggregation (GO:0070486)2.70142453
48regulation of integrin activation (GO:0033623)2.69540816
49regulation of interferon-beta biosynthetic process (GO:0045357)2.69056963
50positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.69011312
51cell adhesion mediated by integrin (GO:0033627)2.66730134
52basement membrane organization (GO:0071711)2.65200903
53positive regulation of receptor recycling (GO:0001921)2.64982795
54positive regulation by symbiont of host defense response (GO:0052509)2.63930540
55modulation by symbiont of host defense response (GO:0052031)2.63930540
56modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.63930540
57modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.63930540
58positive regulation by organism of defense response of other organism involved in symbiotic interact2.63930540
59modulation by symbiont of host immune response (GO:0052553)2.63930540
60regulation of interferon-alpha production (GO:0032647)2.63771919
61myeloid cell activation involved in immune response (GO:0002275)2.62796958
62sequestering of actin monomers (GO:0042989)2.62611990
63negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.62333067
64epithelial cell-cell adhesion (GO:0090136)2.62077117
65embryonic process involved in female pregnancy (GO:0060136)2.61643865
66positive regulation of endothelial cell apoptotic process (GO:2000353)2.61431005
67modulation by symbiont of host cellular process (GO:0044068)2.61410270
68neutrophil activation (GO:0042119)2.60967200
69regulation of short-term neuronal synaptic plasticity (GO:0048172)2.60594853
70hyaluronan catabolic process (GO:0030214)2.59514057
71macrophage activation involved in immune response (GO:0002281)2.58830480
72G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.56829984
73regulation of T-helper 1 cell differentiation (GO:0045625)2.56512239
74granulocyte activation (GO:0036230)2.55519873
75cortical actin cytoskeleton organization (GO:0030866)2.54595661
76actin filament capping (GO:0051693)2.53825819
77hemidesmosome assembly (GO:0031581)2.52767575
78positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.52142871
79B cell receptor signaling pathway (GO:0050853)2.51811476
80regulation of extracellular matrix disassembly (GO:0010715)2.51654080
81retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.51320691
82regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.51161268
83positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.50782075
84mannose metabolic process (GO:0006013)2.50354326
85pentose-phosphate shunt (GO:0006098)2.49627402
86stress fiber assembly (GO:0043149)2.49155304
87regulation of type I interferon-mediated signaling pathway (GO:0060338)2.49081210
88thymic T cell selection (GO:0045061)2.48527624
89immunoglobulin mediated immune response (GO:0016064)2.48316168
90sodium ion export (GO:0071436)2.47325195
91myeloid dendritic cell differentiation (GO:0043011)2.47212829
92positive regulation of antigen processing and presentation (GO:0002579)2.47002204
93substrate-dependent cell migration (GO:0006929)2.45439334
94negative regulation of phagocytosis (GO:0050765)2.45077235
95maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.44604365
96lipopolysaccharide-mediated signaling pathway (GO:0031663)2.44426104
97T cell selection (GO:0045058)2.44303224
98positive regulation of lamellipodium assembly (GO:0010592)2.43465024
99Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.43277128
100negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.42797435
101cytoskeletal anchoring at plasma membrane (GO:0007016)2.42392725
102regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.41805908
103exploration behavior (GO:0035640)2.41804191
104regulation of T cell tolerance induction (GO:0002664)2.41683956
105leukocyte cell-cell adhesion (GO:0007159)2.41486385
106positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.40243098
107immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.39538853
108Fc-gamma receptor signaling pathway (GO:0038094)2.39538853
109Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.39538853
110mast cell activation (GO:0045576)2.38999669
111protein retention in ER lumen (GO:0006621)2.38965915
112negative regulation of actin filament polymerization (GO:0030837)2.38317242
113regulation of gamma-delta T cell differentiation (GO:0045586)2.37884946
114angiogenesis involved in wound healing (GO:0060055)2.37078890
115membrane protein ectodomain proteolysis (GO:0006509)2.36998140
116homotypic cell-cell adhesion (GO:0034109)2.35956509
117positive regulation of lamellipodium organization (GO:1902745)2.35952272
118natural killer cell differentiation (GO:0001779)2.35646173
119wound healing, spreading of epidermal cells (GO:0035313)2.35447147
120response to muramyl dipeptide (GO:0032495)2.35330226
121myeloid dendritic cell activation (GO:0001773)2.35259147
122neuromuscular process controlling balance (GO:0050885)2.35227945
123response to interleukin-15 (GO:0070672)2.35226577
124wound healing, spreading of cells (GO:0044319)2.34391128
125negative regulation of protein localization to plasma membrane (GO:1903077)2.33816377
126positive regulation of axon extension (GO:0045773)2.33693317
127regulation of antigen processing and presentation (GO:0002577)2.33027777
128antigen processing and presentation via MHC class Ib (GO:0002475)2.31711237
129fibril organization (GO:0097435)2.31492507
130vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.30350045
131positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.28250818
132positive regulation of extracellular matrix organization (GO:1903055)2.28196036
133dendritic cell differentiation (GO:0097028)2.27855642
134heterotypic cell-cell adhesion (GO:0034113)2.27445082
135negative regulation of stress fiber assembly (GO:0051497)2.25000694
136JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.24126382
137natural killer cell mediated immunity (GO:0002228)2.24032404
138natural killer cell mediated cytotoxicity (GO:0042267)2.24032404
139regulation of ARF GTPase activity (GO:0032312)2.23694312
140regulation of leukocyte degranulation (GO:0043300)2.23532257
141cellular response to interferon-alpha (GO:0035457)2.22878345
142positive regulation of macrophage differentiation (GO:0045651)2.22465378
143regulation of gamma-delta T cell activation (GO:0046643)2.22407797
144detection of other organism (GO:0098543)2.22093293
145regulation of defense response to virus by virus (GO:0050690)2.22009117
146actin filament bundle assembly (GO:0051017)2.21414550
147actin filament bundle organization (GO:0061572)2.21414550
148negative regulation of anoikis (GO:2000811)2.21377553
149protein maturation by protein folding (GO:0022417)2.21060713
150response to peptidoglycan (GO:0032494)2.20733695
151positive regulation of fibroblast migration (GO:0010763)2.20692821
152positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.20692208
153apoptotic cell clearance (GO:0043277)2.20555409
154cortical cytoskeleton organization (GO:0030865)2.19966405
155negative regulation of interleukin-12 production (GO:0032695)2.19442273
156positive thymic T cell selection (GO:0045059)2.19332897
157integrin-mediated signaling pathway (GO:0007229)2.18225447
158actin filament depolymerization (GO:0030042)2.17856998
159endocytic recycling (GO:0032456)2.17748404
160leukocyte degranulation (GO:0043299)2.16921746
161hepatocyte apoptotic process (GO:0097284)2.16116209
162negative regulation of homotypic cell-cell adhesion (GO:0034111)2.15409178
163regulation of necroptotic process (GO:0060544)2.14168018
164mesodermal cell differentiation (GO:0048333)2.13762433
165negative regulation of fatty acid transport (GO:2000192)2.13680671
166adhesion of symbiont to host cell (GO:0044650)2.12580642
167virion attachment to host cell (GO:0019062)2.12580642
168detection of bacterium (GO:0016045)2.11679769
169regulation of transforming growth factor beta1 production (GO:0032908)2.11077446

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.96549095
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.93336101
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.87422134
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.79155303
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.76892247
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.76639531
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.91057589
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.60565454
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.57714428
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51922112
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.43626306
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.40929497
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40630236
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.37403644
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.37301931
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.33225094
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.30814421
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.20941980
19SPI1_23127762_ChIP-Seq_K562_Human2.04150823
20* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.03588161
21* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.02648044
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.97290600
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.96672079
24KDM2B_26808549_Chip-Seq_DND41_Human1.93793374
25* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88106413
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.87770512
27MAF_26560356_Chip-Seq_TH1_Human1.87518708
28RUNX_20019798_ChIP-Seq_JUKART_Human1.85043218
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76863380
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76645320
31GATA1_22025678_ChIP-Seq_K562_Human1.76577538
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75777527
33VDR_24763502_ChIP-Seq_THP-1_Human1.73492456
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.70511161
35TCF7_22412390_ChIP-Seq_EML_Mouse1.70267713
36* ELK3_25401928_ChIP-Seq_HUVEC_Human1.68034876
37MYC_22102868_ChIP-Seq_BL_Human1.67872333
38MYB_26560356_Chip-Seq_TH2_Human1.67718042
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.64685164
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63889652
41* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.63725068
42VDR_21846776_ChIP-Seq_THP-1_Human1.57916927
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53803948
44RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.53297181
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52928024
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51503180
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50426975
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49049016
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48437452
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47794180
51UTX_26944678_Chip-Seq_JUKART_Human1.47509971
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.46865951
53NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.45548804
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.45328967
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44043273
56VDR_24787735_ChIP-Seq_THP-1_Human1.41932527
57DROSHA_22980978_ChIP-Seq_HELA_Human1.40497163
58* GATA2_21666600_ChIP-Seq_HMVEC_Human1.39100508
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.38693058
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35739929
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.31019313
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30769147
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30423689
64SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.29818414
65SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.29818414
66ATF3_27146783_Chip-Seq_COLON_Human1.29718477
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29661712
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28383037
69* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27772836
70E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26862723
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26614898
72* MYB_26560356_Chip-Seq_TH1_Human1.25831950
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25394356
74* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24500418
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24264650
76ZNF263_19887448_ChIP-Seq_K562_Human1.24213028
77TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23822598
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21774670
79* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21763543
80PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18275007
81TP53_22127205_ChIP-Seq_IMR90_Human1.18225192
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17891744
83NCOR1_26117541_ChIP-Seq_K562_Human1.17641043
84KDM2B_26808549_Chip-Seq_K562_Human1.17110182
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16658020
86GATA3_27048872_Chip-Seq_THYMUS_Human1.15819679
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15521118
88* LXR_22292898_ChIP-Seq_THP-1_Human1.14864290
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14759343
90MAF_26560356_Chip-Seq_TH2_Human1.14696787
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13309798
92RARB_27405468_Chip-Seq_BRAIN_Mouse1.13296546
93PU_27001747_Chip-Seq_BMDM_Mouse1.12582565
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11897757
95CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11233399
96BRD4_25478319_ChIP-Seq_HGPS_Human1.10095079
97SPI1_23547873_ChIP-Seq_NB4_Human1.09388835
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09249190
99ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09095265
100P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08748358
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07951995
102GATA1_19941827_ChIP-Seq_MEL_Mouse1.07836436
103MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07733199
104CLOCK_20551151_ChIP-Seq_293T_Human1.06589395
105ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05976836
106PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05877689
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05074872
108CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04315581
109MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03232725
110THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03159893
111ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02661308
112CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02278430
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01753857
114WT1_19549856_ChIP-ChIP_CCG9911_Human1.00870284
115CJUN_26792858_Chip-Seq_BT549_Human1.00595760
116* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00145570
117KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00142218
118SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99110027
119HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99054991
120STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98710766
121ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97537364
122* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96760311
123* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96494112
124EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95021200
125ESR2_21235772_ChIP-Seq_MCF-7_Human0.93194055
126UBF1/2_26484160_Chip-Seq_HMECs_Human0.92661279
127* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90555493
128* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90003351
129* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89995106
130* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88380445
131GATA1_19941826_ChIP-Seq_K562_Human0.87413102
132RXR_22108803_ChIP-Seq_LS180_Human0.87153225
133TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.86317143
134RACK7_27058665_Chip-Seq_MCF-7_Human0.85878126

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.23534532
2MP0001835_abnormal_antigen_presentation3.21877798
3MP0004859_abnormal_synaptic_plasticity3.00287907
4MP0004510_myositis2.75071636
5MP0003705_abnormal_hypodermis_morpholog2.70977373
6MP0008438_abnormal_cutaneous_collagen2.55607265
7MP0003303_peritoneal_inflammation2.46508759
8MP0003436_decreased_susceptibility_to2.39981794
9MP0010352_gastrointestinal_tract_polyps2.31933861
10MP0000685_abnormal_immune_system2.28990842
11MP0003566_abnormal_cell_adhesion2.28833141
12MP0005451_abnormal_body_composition2.17229244
13MP0005000_abnormal_immune_tolerance2.16849613
14MP0003091_abnormal_cell_migration2.14724128
15MP0002148_abnormal_hypersensitivity_rea2.14242925
16MP0009785_altered_susceptibility_to2.13459832
17MP0003191_abnormal_cellular_cholesterol2.13415753
18MP0005257_abnormal_intraocular_pressure2.06970397
19MP0005058_abnormal_lysosome_morphology2.05261921
20MP0003300_gastrointestinal_ulcer2.04569248
21* MP0002419_abnormal_innate_immunity2.00388320
22MP0005671_abnormal_response_to1.98401436
23MP0003279_aneurysm1.96836072
24MP0009840_abnormal_foam_cell1.96270273
25* MP0002452_abnormal_antigen_presenting1.95138693
26MP0003075_altered_response_to1.91416995
27MP0005387_immune_system_phenotype1.87756672
28MP0001790_abnormal_immune_system1.87756672
29MP0001958_emphysema1.85451727
30MP0002166_altered_tumor_susceptibility1.78928027
31MP0001800_abnormal_humoral_immune1.78773205
32MP0008260_abnormal_autophagy1.77634394
33* MP0001819_abnormal_immune_cell1.74964276
34* MP0002420_abnormal_adaptive_immunity1.74810888
35MP0003172_abnormal_lysosome_physiology1.72002026
36MP0003879_abnormal_hair_cell1.71733376
37MP0002723_abnormal_immune_serum1.69481486
38MP0005623_abnormal_meninges_morphology1.64781895
39MP0005025_abnormal_response_to1.63922141
40MP0002006_tumorigenesis1.63875415
41MP0004858_abnormal_nervous_system1.63551968
42MP0003045_fibrosis1.62969372
43MP0010234_abnormal_vibrissa_follicle1.62556589
44MP0001533_abnormal_skeleton_physiology1.56743864
45MP0003453_abnormal_keratinocyte_physiol1.54120961
46MP0001348_abnormal_lacrimal_gland1.53029754
47MP0010307_abnormal_tumor_latency1.50930380
48MP0003448_altered_tumor_morphology1.50509713
49MP0010368_abnormal_lymphatic_system1.48439278
50* MP0004947_skin_inflammation1.47758910
51MP0002405_respiratory_system_inflammati1.46927600
52MP0000858_altered_metastatic_potential1.46306408
53MP0000604_amyloidosis1.40246834
54MP0005023_abnormal_wound_healing1.40187647
55MP0005464_abnormal_platelet_physiology1.39117465
56MP0005076_abnormal_cell_differentiation1.38520688
57MP0002877_abnormal_melanocyte_morpholog1.38192552
58* MP0002398_abnormal_bone_marrow1.35546300
59MP0006082_CNS_inflammation1.34910968
60MP0003950_abnormal_plasma_membrane1.32295957
61MP0003763_abnormal_thymus_physiology1.29597375
62MP0005310_abnormal_salivary_gland1.27144795
63* MP0000716_abnormal_immune_system1.26429214
64MP0002060_abnormal_skin_morphology1.25099557
65MP0004808_abnormal_hematopoietic_stem1.22988685
66MP0005166_decreased_susceptibility_to1.22077298
67MP0006054_spinal_hemorrhage1.22046980
68MP0001542_abnormal_bone_strength1.20220440
69MP0010155_abnormal_intestine_physiology1.20046087
70MP0005275_abnormal_skin_tensile1.19830696
71MP0003635_abnormal_synaptic_transmissio1.19696767
72MP0000343_altered_response_to1.14346721
73MP0000013_abnormal_adipose_tissue1.14180302
74* MP0002998_abnormal_bone_remodeling1.12432716
75MP0002796_impaired_skin_barrier1.09228309
76* MP0001845_abnormal_inflammatory_respons1.08733354
77MP0002933_joint_inflammation1.07390675
78MP0008004_abnormal_stomach_pH1.06534364
79MP0008961_abnormal_basal_metabolism1.06097862
80MP0000490_abnormal_crypts_of1.05797682
81MP0001915_intracranial_hemorrhage1.04731106
82MP0002396_abnormal_hematopoietic_system1.04386987
83* MP0001849_ear_inflammation1.02816489
84MP0005165_increased_susceptibility_to1.02007224
85MP0005397_hematopoietic_system_phenotyp1.00225481
86MP0001545_abnormal_hematopoietic_system1.00225481
87MP0000767_abnormal_smooth_muscle1.00114372
88MP0003329_amyloid_beta_deposits0.98687200
89MP0004270_analgesia0.97699885
90* MP0002429_abnormal_blood_cell0.97245084
91MP0005621_abnormal_cell_physiology0.97051699
92MP0009046_muscle_twitch0.96770216
93MP0004185_abnormal_adipocyte_glucose0.95752016
94MP0004233_abnormal_muscle_weight0.95356500
95MP0002722_abnormal_immune_system0.94229443
96MP0001851_eye_inflammation0.93886237
97MP0005501_abnormal_skin_physiology0.93721201
98MP0000689_abnormal_spleen_morphology0.93696730
99MP0001243_abnormal_dermal_layer0.93282896
100MP0003828_pulmonary_edema0.91650422
101MP0005409_darkened_coat_color0.90871809
102MP0005167_abnormal_blood-brain_barrier0.90498981
103MP0004811_abnormal_neuron_physiology0.89189727
104MP0002063_abnormal_learning/memory/cond0.88650425
105MP0002254_reproductive_system_inflammat0.87220172
106MP0002896_abnormal_bone_mineralization0.84955527
107MP0003724_increased_susceptibility_to0.84871039
108MP0009333_abnormal_splenocyte_physiolog0.83209151
109MP0009745_abnormal_behavioral_response0.82940425
110MP0000733_abnormal_muscle_development0.82691929
111* MP0003795_abnormal_bone_structure0.81503998
112MP0002295_abnormal_pulmonary_circulatio0.79289163
113MP0009278_abnormal_bone_marrow0.78844393
114MP0005164_abnormal_response_to0.78790702
115MP0003941_abnormal_skin_development0.77807950
116MP0009384_cardiac_valve_regurgitation0.77051462
117MP0000703_abnormal_thymus_morphology0.76959244
118MP0000249_abnormal_blood_vessel0.76820934
119MP0001881_abnormal_mammary_gland0.75301817
120MP0001853_heart_inflammation0.74917646
121MP0005390_skeleton_phenotype0.74915714
122MP0004883_abnormal_blood_vessel0.74641529
123* MP0001216_abnormal_epidermal_layer0.74227294
124MP0002064_seizures0.73411102
125MP0000465_gastrointestinal_hemorrhage0.71460017
126MP0003283_abnormal_digestive_organ0.71238451
127MP0008874_decreased_physiological_sensi0.70464836
128MP0008469_abnormal_protein_level0.69956515
129MP0000371_diluted_coat_color0.68129258
130MP0004272_abnormal_basement_membrane0.67735229

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.83299360
2Recurrent abscess formation (HP:0002722)3.67709990
3Cerebral aneurysm (HP:0004944)3.67410619
4Recurrent bacterial skin infections (HP:0005406)3.07710081
5Dilatation of the ascending aorta (HP:0005111)2.94719241
6Absent frontal sinuses (HP:0002688)2.92458111
7Aortic aneurysm (HP:0004942)2.89911773
8Frequent falls (HP:0002359)2.84404731
9Protrusio acetabuli (HP:0003179)2.80149663
10Cellulitis (HP:0100658)2.79049911
11Premature rupture of membranes (HP:0001788)2.77229290
12Apathy (HP:0000741)2.76260664
13Diminished motivation (HP:0000745)2.75983562
14Elevated erythrocyte sedimentation rate (HP:0003565)2.74830848
15Lower limb amyotrophy (HP:0007210)2.68731473
16Myositis (HP:0100614)2.65306956
17Ankle contracture (HP:0006466)2.64716608
18Abnormal platelet volume (HP:0011876)2.62460079
19Aortic dissection (HP:0002647)2.60081128
20Vascular tortuosity (HP:0004948)2.58286212
21Arterial tortuosity (HP:0005116)2.55062652
22Increased mean platelet volume (HP:0011877)2.54825761
23Distal lower limb muscle weakness (HP:0009053)2.54631251
24Mediastinal lymphadenopathy (HP:0100721)2.51547096
25Spinal rigidity (HP:0003306)2.51542097
26Increased cerebral lipofuscin (HP:0011813)2.47357884
27Myocardial infarction (HP:0001658)2.45629954
28Distal upper limb amyotrophy (HP:0007149)2.44831175
29Upper limb amyotrophy (HP:0009129)2.44831175
30Fragile skin (HP:0001030)2.40779274
31Vertebral compression fractures (HP:0002953)2.38757997
32Peritonitis (HP:0002586)2.38436547
33Hematochezia (HP:0002573)2.36492952
34Short nail (HP:0001799)2.36070436
35Increased density of long bones (HP:0006392)2.35966439
36Achilles tendon contracture (HP:0001771)2.35351335
37Spinal muscular atrophy (HP:0007269)2.35232292
38Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.33349038
39Hand muscle atrophy (HP:0009130)2.33144885
40Polygenic inheritance (HP:0010982)2.32819713
41Abnormality of macrophages (HP:0004311)2.31953358
42Recurrent fungal infections (HP:0002841)2.31785734
43Cervical subluxation (HP:0003308)2.31554618
44Distal lower limb amyotrophy (HP:0008944)2.30627520
45Blue sclerae (HP:0000592)2.30171572
46Papilledema (HP:0001085)2.24245024
47Abnormality of liposaccharide metabolism (HP:0010968)2.19690386
48Abnormality of glycosphingolipid metabolism (HP:0004343)2.19690386
49Abnormality of glycolipid metabolism (HP:0010969)2.19690386
50Abnormality of skeletal muscle fiber size (HP:0012084)2.14922327
51Abnormality of the Achilles tendon (HP:0005109)2.14582150
52Increased variability in muscle fiber diameter (HP:0003557)2.14416181
53Spontaneous hematomas (HP:0007420)2.11264446
54Orchitis (HP:0100796)2.09673266
55Disproportionate tall stature (HP:0001519)2.08763921
56Autoimmune thrombocytopenia (HP:0001973)2.08470606
57Dysostosis multiplex (HP:0000943)2.07713748
58Thin bony cortex (HP:0002753)2.07145781
59Abnormality of the frontal sinuses (HP:0002687)2.06886596
60Recurrent viral infections (HP:0004429)2.06814397
61Recurrent gram-negative bacterial infections (HP:0005420)2.06429375
62Centrally nucleated skeletal muscle fibers (HP:0003687)2.05300247
63Menorrhagia (HP:0000132)2.04346701
64Myokymia (HP:0002411)2.03957629
65Chronic otitis media (HP:0000389)2.03947768
66Mitral regurgitation (HP:0001653)2.02720445
67Ulnar bowing (HP:0003031)2.01198102
68Persistence of primary teeth (HP:0006335)1.99747060
69Syringomyelia (HP:0003396)1.99354290
70Spinal cord lesions (HP:0100561)1.99354290
71Arterial thrombosis (HP:0004420)1.98561215
72Action tremor (HP:0002345)1.96652552
73Osteolytic defects of the phalanges of the hand (HP:0009771)1.96270694
74Osteolytic defects of the hand bones (HP:0009699)1.96270694
75Abnormality of oral frenula (HP:0000190)1.95351115
76Pointed chin (HP:0000307)1.94805132
77Increased neuronal autofluorescent lipopigment (HP:0002074)1.94629528
78Gingivitis (HP:0000230)1.94289657
79Shallow orbits (HP:0000586)1.93808432
80Difficulty climbing stairs (HP:0003551)1.93484597
81Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.92238697
82Disinhibition (HP:0000734)1.91485199
83Inappropriate behavior (HP:0000719)1.90876973
84Broad face (HP:0000283)1.90767209
85Interstitial pulmonary disease (HP:0006530)1.89646016
86Flat acetabular roof (HP:0003180)1.88150889
87Subacute progressive viral hepatitis (HP:0006572)1.87977435
88Radial bowing (HP:0002986)1.87941298
89Atrophic scars (HP:0001075)1.86716678
90Increased connective tissue (HP:0009025)1.86640976
91Epistaxis (HP:0000421)1.85942804
92Elbow flexion contracture (HP:0002987)1.85940459
93Bladder diverticulum (HP:0000015)1.85718382
94Wormian bones (HP:0002645)1.84967222
95Recurrent skin infections (HP:0001581)1.84921778
96Bowel diverticulosis (HP:0005222)1.83911719
97Spondylolisthesis (HP:0003302)1.82783166
98Pulmonary infiltrates (HP:0002113)1.82099772
99Long palpebral fissure (HP:0000637)1.80522258
100Slender build (HP:0001533)1.80413258
101Mitral valve prolapse (HP:0001634)1.79752486
102Retrobulbar optic neuritis (HP:0100654)1.78927137
103Optic neuritis (HP:0100653)1.78927137
104Genu recurvatum (HP:0002816)1.78903866
105Mildly elevated creatine phosphokinase (HP:0008180)1.78838132
106Petechiae (HP:0000967)1.76071640
107Hyperacusis (HP:0010780)1.75714524
108Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.75509231
109Prolonged bleeding time (HP:0003010)1.75114494
110Abnormality of the distal phalanges of the toes (HP:0010182)1.74932371
111Natal tooth (HP:0000695)1.74599110
112Purpura (HP:0000979)1.74283780
113Striae distensae (HP:0001065)1.74023760
114Joint laxity (HP:0001388)1.73279872
115Mucopolysacchariduria (HP:0008155)1.72368090
116Urinary glycosaminoglycan excretion (HP:0003541)1.72368090
117Vacuolated lymphocytes (HP:0001922)1.72029310
118Periodontitis (HP:0000704)1.69902710
119Mutism (HP:0002300)1.69411525
120Abnormal platelet function (HP:0011869)1.69391538
121Impaired platelet aggregation (HP:0003540)1.69391538
122Vasculitis (HP:0002633)1.68850920
123Aneurysm (HP:0002617)1.68667323
124Hemiplegia (HP:0002301)1.68247685
125Biconcave vertebral bodies (HP:0004586)1.67891818
126Generalized amyotrophy (HP:0003700)1.67627772
127Abnormal ossification of hand bones (HP:0005921)1.67428985
128Bilateral sensorineural hearing impairment (HP:0008619)1.66433658
129Hemorrhage of the eye (HP:0011885)1.65897111
130Abnormality of the acetabulum (HP:0003170)1.65059673
131Type 1 muscle fiber predominance (HP:0003803)1.63890862
132Scapular winging (HP:0003691)1.63833632
133Abnormality of T cell number (HP:0011839)1.63718802
134Abnormality of dentin (HP:0010299)1.63534132
135Recurrent bronchitis (HP:0002837)1.62949433
136Palpebral edema (HP:0100540)1.62781097
137Reduced subcutaneous adipose tissue (HP:0003758)1.62062700
138Polycythemia (HP:0001901)1.60326066
139Mitral stenosis (HP:0001718)1.60238677
140Osteomyelitis (HP:0002754)1.59295339
141Thrombocytosis (HP:0001894)1.59106203
142Stomatitis (HP:0010280)1.58845959
143Loss of speech (HP:0002371)1.58363449
144Bicuspid aortic valve (HP:0001647)1.58234906
145Soft skin (HP:0000977)1.58008224
146Hypercortisolism (HP:0001578)1.57890388
147Emphysema (HP:0002097)1.57864425
148Bone pain (HP:0002653)1.57856747
149Gastrointestinal dysmotility (HP:0002579)1.57694438
150Focal seizures (HP:0007359)1.57676509
151Chronic obstructive pulmonary disease (HP:0006510)1.56882027
152Obstructive lung disease (HP:0006536)1.56882027
153Axonal loss (HP:0003447)1.56109730
154Trismus (HP:0000211)1.56072090
155Ankyloglossia (HP:0010296)1.55333310

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.26787098
2PRPF4B3.16034420
3NTRK12.85914177
4SMG12.73101198
5IRAK32.67541872
6TESK12.66229990
7TTN2.59859426
8RIPK12.55505452
9SCYL22.40789445
10MAP3K92.32006209
11TRIB32.20643445
12MAP4K12.09904570
13MAP3K142.03461632
14TBK11.95476366
15PKN21.91501206
16PAK41.91443085
17MAP2K31.85906203
18JAK31.78975483
19TAOK11.74324877
20EPHA21.73891934
21TAOK21.72823332
22TESK21.71337502
23ICK1.71152660
24CAMKK11.66705704
25SIK11.66498580
26PAK61.65114352
27BLK1.64724737
28MYLK1.61615591
29LIMK11.58144189
30MAP3K31.56566846
31JAK11.52820709
32CDK121.51258177
33MAP3K131.50427766
34TYK21.50418705
35MINK11.45738056
36NME21.42097944
37LRRK21.41157584
38KIT1.38214249
39STK101.32468471
40BMX1.32391237
41DMPK1.31512559
42LATS21.30056633
43NTRK21.27767127
44FES1.25337347
45EPHA31.23319925
46ALK1.20371721
47TRPM71.16947349
48HCK1.16753854
49EPHA41.16538382
50CDC42BPA1.13884242
51CSF1R1.12239942
52ZAP701.11117962
53MST1R1.08510755
54ERBB31.07016971
55IKBKE1.07005534
56EEF2K1.02582262
57KSR21.01848808
58ILK1.01039950
59ITK0.99640043
60CAMKK20.99450760
61LMTK20.98357733
62RPS6KA40.98331577
63MAP3K110.98001258
64FGFR30.96674414
65SIK20.95656166
66BMPR20.95264612
67PTK60.94749724
68MAP3K80.93676865
69PRKD20.93539495
70IRAK40.93474059
71IKBKB0.91744314
72MAP3K10.89551822
73PAK30.88136986
74SYK0.86430014
75PDGFRA0.86072712
76ROCK10.82962140
77TXK0.82858578
78PTK2B0.82085952
79TGFBR20.81413396
80RET0.81127186
81SIK30.79680139
82PLK20.79333587
83CSK0.78912996
84PRKG20.78101146
85FYN0.77608638
86DAPK30.77572715
87DDR20.76848195
88CDK50.76282496
89RPS6KA20.76086514
90PTK20.75048530
91PIM20.74755186
92PDGFRB0.73237631
93PRKCH0.71963639
94FGR0.71515126
95NTRK30.70220950
96RAF10.69135485
97LCK0.69054353
98DAPK20.68622461
99MAP3K60.67687610
100CDK60.67159395
101MTOR0.66485582
102MET0.66221515
103DAPK10.63583242
104KDR0.63069227
105PDPK10.62000340
106ERBB40.61831150
107MOS0.61605287
108NEK90.61267831
109FRK0.60676069
110EPHB10.58557295
111ARAF0.58321360
112STK380.55801727
113ERN10.55484101
114EGFR0.54852855
115MAP3K100.54807846
116EPHB20.54523944
117PAK20.53683219
118FGFR40.53435253
119MAP2K10.53100624
120MAPKAPK20.52021519
121PDK10.51740326
122PAK10.51490222
123MELK0.51305327
124ROCK20.50531293
125PRKCQ0.50310861
126BTK0.49946456
127MARK30.49914323
128GRK60.49841049
129CLK10.49753114
130SRC0.48810800
131INSR0.48031478
132TEC0.47650578
133RPS6KC10.47384093
134RPS6KL10.47384093
135LYN0.47364539
136PRKCD0.46909762
137MARK10.46600393
138KSR10.46570995
139MAPK110.45969469
140JAK20.45708259
141CDK40.43496407
142PIK3CG0.37497109
143HIPK20.36712853
144MARK20.36615967

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.15231630
2Other glycan degradation_Homo sapiens_hsa005112.09675175
3Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.89298152
4Leishmaniasis_Homo sapiens_hsa051401.86252018
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.79390021
6Bladder cancer_Homo sapiens_hsa052191.69222323
7Osteoclast differentiation_Homo sapiens_hsa043801.61598960
8Salmonella infection_Homo sapiens_hsa051321.57288866
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49421642
10Shigellosis_Homo sapiens_hsa051311.47925564
11Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.43107918
12Viral myocarditis_Homo sapiens_hsa054161.42250479
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40765998
14Tuberculosis_Homo sapiens_hsa051521.37904244
15B cell receptor signaling pathway_Homo sapiens_hsa046621.37082656
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.36642882
17ECM-receptor interaction_Homo sapiens_hsa045121.35961614
18Neurotrophin signaling pathway_Homo sapiens_hsa047221.31553016
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.31485500
20TNF signaling pathway_Homo sapiens_hsa046681.30675311
21Glioma_Homo sapiens_hsa052141.29855374
22Central carbon metabolism in cancer_Homo sapiens_hsa052301.28117830
23Chemokine signaling pathway_Homo sapiens_hsa040621.24390452
24Pentose phosphate pathway_Homo sapiens_hsa000301.23533332
25Platelet activation_Homo sapiens_hsa046111.23104349
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22459016
27Thyroid cancer_Homo sapiens_hsa052161.21982525
28Pertussis_Homo sapiens_hsa051331.21248818
29Graft-versus-host disease_Homo sapiens_hsa053321.20527971
30Chronic myeloid leukemia_Homo sapiens_hsa052201.20433891
31Olfactory transduction_Homo sapiens_hsa047401.20421819
32Toxoplasmosis_Homo sapiens_hsa051451.18940248
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.18620490
34Apoptosis_Homo sapiens_hsa042101.17800832
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17274387
36Measles_Homo sapiens_hsa051621.17006864
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15622923
38Renal cell carcinoma_Homo sapiens_hsa052111.15101677
39Galactose metabolism_Homo sapiens_hsa000521.14582740
40Antigen processing and presentation_Homo sapiens_hsa046121.10636149
41Focal adhesion_Homo sapiens_hsa045101.10283059
42Hepatitis C_Homo sapiens_hsa051601.09735820
43Allograft rejection_Homo sapiens_hsa053301.09535923
44T cell receptor signaling pathway_Homo sapiens_hsa046601.08472964
45Prion diseases_Homo sapiens_hsa050201.08084813
46Phagosome_Homo sapiens_hsa041451.05842527
47Long-term potentiation_Homo sapiens_hsa047201.05458420
48Proteoglycans in cancer_Homo sapiens_hsa052051.04992361
49Lysosome_Homo sapiens_hsa041421.04324182
50Dilated cardiomyopathy_Homo sapiens_hsa054141.02875259
51Synaptic vesicle cycle_Homo sapiens_hsa047211.02155495
52Malaria_Homo sapiens_hsa051441.01317545
53Type I diabetes mellitus_Homo sapiens_hsa049401.01293739
54Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00172202
55Legionellosis_Homo sapiens_hsa051341.00007825
56VEGF signaling pathway_Homo sapiens_hsa043700.99300299
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98475389
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96680007
59Primary immunodeficiency_Homo sapiens_hsa053400.96534725
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95997099
61Systemic lupus erythematosus_Homo sapiens_hsa053220.95512893
62Pancreatic cancer_Homo sapiens_hsa052120.94940076
63Salivary secretion_Homo sapiens_hsa049700.94550028
64Hepatitis B_Homo sapiens_hsa051610.94345307
65Amoebiasis_Homo sapiens_hsa051460.93606337
66Gastric acid secretion_Homo sapiens_hsa049710.92791262
67Adherens junction_Homo sapiens_hsa045200.92554756
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.92533136
69Endocytosis_Homo sapiens_hsa041440.91869277
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91415303
71Influenza A_Homo sapiens_hsa051640.89634661
72Notch signaling pathway_Homo sapiens_hsa043300.89618038
73Herpes simplex infection_Homo sapiens_hsa051680.87890073
74Viral carcinogenesis_Homo sapiens_hsa052030.87856340
75Circadian entrainment_Homo sapiens_hsa047130.87655019
76Estrogen signaling pathway_Homo sapiens_hsa049150.87537202
77Cholinergic synapse_Homo sapiens_hsa047250.87087523
78HTLV-I infection_Homo sapiens_hsa051660.86740537
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86349344
80Prostate cancer_Homo sapiens_hsa052150.84840298
81Oxytocin signaling pathway_Homo sapiens_hsa049210.82383207
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81957413
83HIF-1 signaling pathway_Homo sapiens_hsa040660.81511114
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81046824
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80108680
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80048008
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79986726
88Type II diabetes mellitus_Homo sapiens_hsa049300.79717031
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79310280
90GnRH signaling pathway_Homo sapiens_hsa049120.79045088
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.78561301
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.78294352
93Endometrial cancer_Homo sapiens_hsa052130.78069629
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77931025
95Rap1 signaling pathway_Homo sapiens_hsa040150.77781903
96Fructose and mannose metabolism_Homo sapiens_hsa000510.77092239
97African trypanosomiasis_Homo sapiens_hsa051430.76546793
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.76284391
99Colorectal cancer_Homo sapiens_hsa052100.76191142
100Non-small cell lung cancer_Homo sapiens_hsa052230.75473783
101Vibrio cholerae infection_Homo sapiens_hsa051100.75425271
102ErbB signaling pathway_Homo sapiens_hsa040120.75225686
103Alcoholism_Homo sapiens_hsa050340.74220165
104Hematopoietic cell lineage_Homo sapiens_hsa046400.73753618
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73430395
106Prolactin signaling pathway_Homo sapiens_hsa049170.72607803
107Small cell lung cancer_Homo sapiens_hsa052220.72589035
108Rheumatoid arthritis_Homo sapiens_hsa053230.72413941
109Autoimmune thyroid disease_Homo sapiens_hsa053200.72383452
110Staphylococcus aureus infection_Homo sapiens_hsa051500.72025063
111MicroRNAs in cancer_Homo sapiens_hsa052060.71575871
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70611345
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69096595
114mTOR signaling pathway_Homo sapiens_hsa041500.68564332
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67909332
116Glutamatergic synapse_Homo sapiens_hsa047240.67867338
117MAPK signaling pathway_Homo sapiens_hsa040100.67667670
118Acute myeloid leukemia_Homo sapiens_hsa052210.67485616
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67455370
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67336506
121Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67248454
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.66222676
123Pathways in cancer_Homo sapiens_hsa052000.62321713
124Epstein-Barr virus infection_Homo sapiens_hsa051690.61741034
125Insulin signaling pathway_Homo sapiens_hsa049100.55177389
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53476536
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53075903
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.50765931

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »