WDR12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.62172744
2DNA deamination (GO:0045006)4.61330695
3maturation of SSU-rRNA (GO:0030490)4.56302273
4telomere maintenance via semi-conservative replication (GO:0032201)4.45813128
5DNA strand elongation involved in DNA replication (GO:0006271)4.43049818
6DNA replication initiation (GO:0006270)4.38315384
7proteasome assembly (GO:0043248)4.35426072
8DNA strand elongation (GO:0022616)4.26173129
9nucleobase biosynthetic process (GO:0046112)4.16543169
10CENP-A containing nucleosome assembly (GO:0034080)4.16214607
11chromatin remodeling at centromere (GO:0031055)4.12707192
12ribosome biogenesis (GO:0042254)4.03918676
13telomere maintenance via recombination (GO:0000722)4.02635258
14DNA replication checkpoint (GO:0000076)4.00022986
15ribosomal small subunit biogenesis (GO:0042274)3.99439662
16purine nucleobase biosynthetic process (GO:0009113)3.98133236
17* ribonucleoprotein complex biogenesis (GO:0022613)3.96180586
18regulation of mitotic spindle checkpoint (GO:1903504)3.95547927
19regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.95547927
20IMP biosynthetic process (GO:0006188)3.89217499
21* ribosomal large subunit biogenesis (GO:0042273)3.83991744
22kinetochore organization (GO:0051383)3.79910488
23telomere maintenance via telomere lengthening (GO:0010833)3.78758721
24formation of translation preinitiation complex (GO:0001731)3.76538817
25mitochondrial RNA metabolic process (GO:0000959)3.74484158
26mitotic recombination (GO:0006312)3.74313648
27mitotic metaphase plate congression (GO:0007080)3.74172676
28ribosome assembly (GO:0042255)3.73998931
29termination of RNA polymerase III transcription (GO:0006386)3.73862964
30transcription elongation from RNA polymerase III promoter (GO:0006385)3.73862964
31pseudouridine synthesis (GO:0001522)3.73045243
32viral transcription (GO:0019083)3.69719849
33* rRNA processing (GO:0006364)3.67922526
34translational termination (GO:0006415)3.67687876
35folic acid-containing compound biosynthetic process (GO:0009396)3.64452140
36spliceosomal snRNP assembly (GO:0000387)3.63460348
37kinetochore assembly (GO:0051382)3.59522523
38* rRNA metabolic process (GO:0016072)3.57077838
39rRNA modification (GO:0000154)3.54889665
40histone exchange (GO:0043486)3.53499975
41negative regulation of DNA-dependent DNA replication (GO:2000104)3.53414397
42DNA replication-independent nucleosome assembly (GO:0006336)3.52555570
43DNA replication-independent nucleosome organization (GO:0034724)3.52555570
44DNA catabolic process, exonucleolytic (GO:0000738)3.51237624
45transcription elongation from RNA polymerase I promoter (GO:0006362)3.48275815
46termination of RNA polymerase I transcription (GO:0006363)3.47954711
47replication fork processing (GO:0031297)3.46707374
48establishment of protein localization to mitochondrial membrane (GO:0090151)3.46325014
49DNA unwinding involved in DNA replication (GO:0006268)3.44744457
50somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.43425707
51isotype switching (GO:0045190)3.43425707
52somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.43425707
53regulation of nuclear cell cycle DNA replication (GO:0033262)3.41768599
54somatic diversification of immune receptors via somatic mutation (GO:0002566)3.38637848
55somatic hypermutation of immunoglobulin genes (GO:0016446)3.38637848
56IMP metabolic process (GO:0046040)3.35145993
57translational elongation (GO:0006414)3.34596573
58nucleotide-excision repair, DNA gap filling (GO:0006297)3.33724888
59transcription-coupled nucleotide-excision repair (GO:0006283)3.31742913
60translational initiation (GO:0006413)3.31637363
61metaphase plate congression (GO:0051310)3.31305049
627-methylguanosine mRNA capping (GO:0006370)3.30634733
63transcription from RNA polymerase I promoter (GO:0006360)3.29095686
64negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.28656612
65RNA capping (GO:0036260)3.27863345
667-methylguanosine RNA capping (GO:0009452)3.27863345
67mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.24365872
68SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.23383090
69regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.23232865
70nuclear pore organization (GO:0006999)3.22262658
71protein K6-linked ubiquitination (GO:0085020)3.21652583
72respiratory chain complex IV assembly (GO:0008535)3.20905621
73* cellular component biogenesis (GO:0044085)3.20162522
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.19774491
75positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.17648182
76cotranslational protein targeting to membrane (GO:0006613)3.16838620
77transcription from mitochondrial promoter (GO:0006390)3.15551320
78deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.15384152
79cullin deneddylation (GO:0010388)3.14220653
80non-recombinational repair (GO:0000726)3.14083987
81double-strand break repair via nonhomologous end joining (GO:0006303)3.14083987
82protein targeting to ER (GO:0045047)3.12851858
83establishment of integrated proviral latency (GO:0075713)3.12829714
84spliceosomal complex assembly (GO:0000245)3.10754109
85mitotic nuclear envelope disassembly (GO:0007077)3.10375716
86DNA replication-dependent nucleosome assembly (GO:0006335)3.09775032
87DNA replication-dependent nucleosome organization (GO:0034723)3.09775032
88DNA damage response, detection of DNA damage (GO:0042769)3.09412032
89nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.08037736
90regulation of double-strand break repair via homologous recombination (GO:0010569)3.07966278
91meiotic chromosome segregation (GO:0045132)3.07739617
92viral mRNA export from host cell nucleus (GO:0046784)3.07076322
93DNA ligation (GO:0006266)3.06882431
94translation (GO:0006412)3.05940993
95mitotic sister chromatid segregation (GO:0000070)3.05675095
96nuclear pore complex assembly (GO:0051292)3.04592494
97exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.04502185
98protein localization to kinetochore (GO:0034501)3.03821759
99deoxyribonucleotide biosynthetic process (GO:0009263)3.03351156
100* maturation of 5.8S rRNA (GO:0000460)3.02809041
101synapsis (GO:0007129)3.02782949
102regulation of centriole replication (GO:0046599)3.02540031
103transcription initiation from RNA polymerase I promoter (GO:0006361)3.02378348
104somatic recombination of immunoglobulin gene segments (GO:0016447)3.02255623
105amino acid activation (GO:0043038)3.01955029
106tRNA aminoacylation (GO:0043039)3.01955029
107* ncRNA processing (GO:0034470)3.01435431
108regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.01418176
109RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.01380688
110tRNA methylation (GO:0030488)3.01088062
111RNA-dependent DNA replication (GO:0006278)3.00449280
112negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.99808269
113negative regulation of ligase activity (GO:0051352)2.99808269
114rRNA methylation (GO:0031167)2.99539549
115DNA-templated transcription, termination (GO:0006353)2.99538510
116cellular protein complex disassembly (GO:0043624)2.99084956
117* ncRNA metabolic process (GO:0034660)2.98369624
118tRNA aminoacylation for protein translation (GO:0006418)2.97743388
119protein localization to endoplasmic reticulum (GO:0070972)2.96743940
120pteridine-containing compound biosynthetic process (GO:0042559)2.96392835
121establishment of chromosome localization (GO:0051303)2.95886780
122spindle checkpoint (GO:0031577)2.95024267
123G1/S transition of mitotic cell cycle (GO:0000082)2.94678997
124cell cycle G1/S phase transition (GO:0044843)2.94678997
125establishment of protein localization to endoplasmic reticulum (GO:0072599)2.94529151
126DNA double-strand break processing (GO:0000729)2.94455476
127chaperone-mediated protein transport (GO:0072321)2.94161751
128maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.94049579
129telomere organization (GO:0032200)2.94033725
130peptidyl-histidine modification (GO:0018202)2.93845942
131nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93778441
132telomere maintenance (GO:0000723)2.93480331
133mitotic spindle checkpoint (GO:0071174)2.93274068
134protein deneddylation (GO:0000338)2.92875469
135DNA-dependent DNA replication (GO:0006261)2.92774350
136protein-cofactor linkage (GO:0018065)2.91443508
137L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.91169903
138sister chromatid segregation (GO:0000819)2.89187482
139telomere maintenance via telomerase (GO:0007004)2.88982414
140negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88282024
141negative regulation of mitotic sister chromatid separation (GO:2000816)2.88282024
142negative regulation of sister chromatid segregation (GO:0033046)2.88282024
143negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.88282024
144negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.88282024
145negative regulation of chromosome segregation (GO:0051985)2.86403007
146mitochondrial respiratory chain complex assembly (GO:0033108)2.85636884
147somatic diversification of immunoglobulins (GO:0016445)2.85200125
148tRNA metabolic process (GO:0006399)2.84619779
149histone mRNA metabolic process (GO:0008334)2.83564691
150regulation of mitochondrial translation (GO:0070129)2.83168291
151regulation of centrosome cycle (GO:0046605)2.80085705
152cytochrome complex assembly (GO:0017004)2.79084316
153recombinational repair (GO:0000725)2.78875178

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.09383412
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.58877537
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.00808646
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.85994108
5* EST1_17652178_ChIP-ChIP_JURKAT_Human3.48988172
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.43369042
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.37976992
8* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.26575040
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.12355058
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.08739615
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.01824271
12* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00273798
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.98226144
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.96078592
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.94183450
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.81277276
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.76124951
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.74958354
19VDR_23849224_ChIP-Seq_CD4+_Human2.60714105
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.56822013
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.47244165
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.46180020
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45331624
24ZNF274_21170338_ChIP-Seq_K562_Hela2.31828117
25FOXP3_21729870_ChIP-Seq_TREG_Human2.30047811
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26427877
27XRN2_22483619_ChIP-Seq_HELA_Human2.25980663
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25974282
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24778576
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.21268676
31DCP1A_22483619_ChIP-Seq_HELA_Human2.13580104
32TTF2_22483619_ChIP-Seq_HELA_Human2.05394544
33* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.05128615
34THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04508537
35E2F1_18555785_ChIP-Seq_MESCs_Mouse2.01280012
36ELK1_19687146_ChIP-ChIP_HELA_Human1.98544271
37* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.92574306
38* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90371172
39GABP_19822575_ChIP-Seq_HepG2_Human1.90318518
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.89017518
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87092166
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86390204
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85683660
44VDR_22108803_ChIP-Seq_LS180_Human1.83356730
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.82411677
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.81320203
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80517082
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77696579
49* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72551117
50FUS_26573619_Chip-Seq_HEK293_Human1.70134777
51AR_21909140_ChIP-Seq_LNCAP_Human1.69544282
52* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67807643
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.62706488
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56054740
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51436743
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49004271
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47563503
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41350556
59CIITA_25753668_ChIP-Seq_RAJI_Human1.40558399
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38173830
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37103855
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35840805
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35495179
64MYC_18940864_ChIP-ChIP_HL60_Human1.32886613
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31646330
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31583463
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29722292
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29481822
69KDM5A_27292631_Chip-Seq_BREAST_Human1.28888505
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27538661
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25797171
72NANOG_16153702_ChIP-ChIP_HESCs_Human1.18685119
73* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17502985
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.17319897
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17087477
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15835726
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.13049424
78IGF1R_20145208_ChIP-Seq_DFB_Human1.10758478
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04829117
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03952366
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03349423
82P300_19829295_ChIP-Seq_ESCs_Human0.98618166
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97873233
84SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95167758
85* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93658865
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93336879
87* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92615916
88IRF1_19129219_ChIP-ChIP_H3396_Human0.91874351
89* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91546488
90CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91498021
91ELK1_22589737_ChIP-Seq_MCF10A_Human0.90796216
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89267890
93TAF15_26573619_Chip-Seq_HEK293_Human0.88924154
94SPI1_23547873_ChIP-Seq_NB4_Human0.88352830
95ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87864100
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85475535
97TFEB_21752829_ChIP-Seq_HELA_Human0.84990910
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84527537
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.84406584
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83470403
101* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81852620
102EGR1_19374776_ChIP-ChIP_THP-1_Human0.81845153
103CTBP2_25329375_ChIP-Seq_LNCAP_Human0.81842742
104STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81334029
105TP53_22573176_ChIP-Seq_HFKS_Human0.81318215
106SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.81083018
107* FLI1_27457419_Chip-Seq_LIVER_Mouse0.78581521
108RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.76425193
109CTBP1_25329375_ChIP-Seq_LNCAP_Human0.75985222
110KLF4_18555785_ChIP-Seq_MESCs_Mouse0.75851697
111SALL1_21062744_ChIP-ChIP_HESCs_Human0.75395314
112* NFE2_27457419_Chip-Seq_LIVER_Mouse0.75090395
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.74539562
114* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74378202
115NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.74226171
116CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74176074
117* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.73745992
118DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.73577871
119* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.72540228
120* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.71671076
121ER_23166858_ChIP-Seq_MCF-7_Human0.71085832
122* EZH2_27294783_Chip-Seq_NPCs_Mouse0.70676039
123CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.69705615
124EWS_26573619_Chip-Seq_HEK293_Human0.64713987
125POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.63794885
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.63690750
127SOX17_20123909_ChIP-Seq_XEN_Mouse0.60676700
128HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.60219873
129SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.59869578

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.23661636
2MP0010094_abnormal_chromosome_stability4.94089804
3MP0008058_abnormal_DNA_repair4.50556552
4MP0003111_abnormal_nucleus_morphology4.43244060
5MP0008057_abnormal_DNA_replication4.15705345
6MP0004957_abnormal_blastocyst_morpholog4.06842095
7MP0003077_abnormal_cell_cycle3.73654223
8MP0008007_abnormal_cellular_replicative3.28192652
9MP0008877_abnormal_DNA_methylation3.13604890
10MP0002396_abnormal_hematopoietic_system2.92785496
11MP0008932_abnormal_embryonic_tissue2.77982356
12MP0003786_premature_aging2.73307317
13MP0006292_abnormal_olfactory_placode2.47309936
14MP0001188_hyperpigmentation2.29573497
15MP0009379_abnormal_foot_pigmentation2.17506358
16MP0003123_paternal_imprinting1.99070327
17MP0003718_maternal_effect1.80959306
18MP0000350_abnormal_cell_proliferation1.73929678
19MP0000490_abnormal_crypts_of1.73051099
20MP0002210_abnormal_sex_determination1.71464200
21MP0006072_abnormal_retinal_apoptosis1.68212454
22MP0003880_abnormal_central_pattern1.60667596
23MP0009697_abnormal_copulation1.58655426
24MP0001730_embryonic_growth_arrest1.56961652
25MP0004808_abnormal_hematopoietic_stem1.54725153
26MP0001929_abnormal_gametogenesis1.53638678
27MP0002132_abnormal_respiratory_system1.48852733
28MP0002160_abnormal_reproductive_system1.45914034
29MP0000015_abnormal_ear_pigmentation1.45907126
30MP0001145_abnormal_male_reproductive1.44836993
31MP0000313_abnormal_cell_death1.41026345
32MP0005174_abnormal_tail_pigmentation1.36799698
33MP0005075_abnormal_melanosome_morpholog1.36595062
34MP0002095_abnormal_skin_pigmentation1.36063727
35MP0005084_abnormal_gallbladder_morpholo1.35234868
36MP0003763_abnormal_thymus_physiology1.34246187
37MP0003937_abnormal_limbs/digits/tail_de1.30067037
38MP0000653_abnormal_sex_gland1.28285857
39MP0008875_abnormal_xenobiotic_pharmacok1.26312179
40MP0005551_abnormal_eye_electrophysiolog1.25305631
41MP0010307_abnormal_tumor_latency1.24624606
42MP0002019_abnormal_tumor_incidence1.23291404
43MP0001986_abnormal_taste_sensitivity1.22274433
44MP0003698_abnormal_male_reproductive1.16962803
45MP0005410_abnormal_fertilization1.16498559
46MP0001672_abnormal_embryogenesis/_devel1.16201709
47MP0005380_embryogenesis_phenotype1.16201709
48MP0001697_abnormal_embryo_size1.15865020
49MP0009333_abnormal_splenocyte_physiolog1.15338118
50MP0002080_prenatal_lethality1.15304584
51MP0003941_abnormal_skin_development1.13629168
52MP0000703_abnormal_thymus_morphology1.12041947
53MP0005389_reproductive_system_phenotype1.10486935
54MP0002837_dystrophic_cardiac_calcinosis1.08743732
55MP0003195_calcinosis1.08041960
56MP0001293_anophthalmia1.07726358
57MP0002398_abnormal_bone_marrow1.06056976
58MP0002102_abnormal_ear_morphology1.05218729
59MP0004147_increased_porphyrin_level1.05062448
60MP0003121_genomic_imprinting1.04564325
61MP0003315_abnormal_perineum_morphology1.04364458
62MP0000631_abnormal_neuroendocrine_gland1.03831284
63MP0003646_muscle_fatigue1.02008012
64MP0004215_abnormal_myocardial_fiber1.01880997
65MP0001485_abnormal_pinna_reflex1.01639591
66MP0008872_abnormal_physiological_respon1.00850813
67MP0001119_abnormal_female_reproductive1.00020784
68MP0005409_darkened_coat_color0.99963862
69MP0001545_abnormal_hematopoietic_system0.98956862
70MP0005397_hematopoietic_system_phenotyp0.98956862
71MP0003984_embryonic_growth_retardation0.97671837
72MP0002722_abnormal_immune_system0.96945893
73MP0008995_early_reproductive_senescence0.96685794
74MP0001529_abnormal_vocalization0.95341160
75MP0000689_abnormal_spleen_morphology0.95238423
76MP0002085_abnormal_embryonic_tissue0.94762715
77MP0003136_yellow_coat_color0.94682390
78MP0003186_abnormal_redox_activity0.94561693
79MP0009672_abnormal_birth_weight0.94144493
80MP0005253_abnormal_eye_physiology0.94069252
81MP0002088_abnormal_embryonic_growth/wei0.93135556
82MP0001661_extended_life_span0.91332580
83MP0000566_synostosis0.90415901
84MP0003950_abnormal_plasma_membrane0.89240325
85MP0003119_abnormal_digestive_system0.88337104
86MP0002736_abnormal_nociception_after0.88245002
87MP0006035_abnormal_mitochondrial_morpho0.86744559
88MP0005408_hypopigmentation0.86271935
89MP0002938_white_spotting0.86221484
90MP0002111_abnormal_tail_morphology0.86173707
91MP0006036_abnormal_mitochondrial_physio0.85714855
92MP0001984_abnormal_olfaction0.84975413
93MP0000358_abnormal_cell_content/0.84583591
94MP0001177_atelectasis0.82700748
95MP0001919_abnormal_reproductive_system0.82206019
96MP0005671_abnormal_response_to0.80860552
97MP0008789_abnormal_olfactory_epithelium0.80447319
98MP0002234_abnormal_pharynx_morphology0.80382497
99MP0001853_heart_inflammation0.79659372
100MP0002429_abnormal_blood_cell0.79172181
101MP0001324_abnormal_eye_pigmentation0.78098246
102MP0002084_abnormal_developmental_patter0.76968851
103MP0005395_other_phenotype0.76319459
104MP0003890_abnormal_embryonic-extraembry0.76267475
105MP0003567_abnormal_fetal_cardiomyocyte0.75634909
106MP0000427_abnormal_hair_cycle0.74569899
107MP0002086_abnormal_extraembryonic_tissu0.73380361
108MP0002697_abnormal_eye_size0.73189264
109MP0002751_abnormal_autonomic_nervous0.72900200
110MP0000858_altered_metastatic_potential0.72476764
111MP0002161_abnormal_fertility/fecundity0.72347426
112MP0001764_abnormal_homeostasis0.71882177
113MP0005332_abnormal_amino_acid0.71636241
114MP0004133_heterotaxia0.71629512
115MP0000647_abnormal_sebaceous_gland0.71567895
116MP0003011_delayed_dark_adaptation0.71347866
117MP0009046_muscle_twitch0.70257955
118MP0000716_abnormal_immune_system0.69872204
119MP0001835_abnormal_antigen_presentation0.69617295
120MP0001186_pigmentation_phenotype0.69362590
121MP0002233_abnormal_nose_morphology0.69081415
122MP0005391_vision/eye_phenotype0.67839531
123MP0002277_abnormal_respiratory_mucosa0.67700573
124MP0002075_abnormal_coat/hair_pigmentati0.67409889
125MP0005171_absent_coat_pigmentation0.66861543
126MP0010352_gastrointestinal_tract_polyps0.65870929
127MP0004197_abnormal_fetal_growth/weight/0.64767979
128MP0003806_abnormal_nucleotide_metabolis0.62963120
129MP0000372_irregular_coat_pigmentation0.60654490
130MP0005384_cellular_phenotype0.60060480
131MP0010030_abnormal_orbit_morphology0.58289675
132MP0002163_abnormal_gland_morphology0.54990194
133MP0003787_abnormal_imprinting0.54335606
134MP0002420_abnormal_adaptive_immunity0.54227807
135MP0002638_abnormal_pupillary_reflex0.53951223
136MP0001286_abnormal_eye_development0.53449203

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.85794151
2Reticulocytopenia (HP:0001896)4.55096081
3Chromsome breakage (HP:0040012)4.53167404
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.49469146
5Abnormality of cells of the erythroid lineage (HP:0012130)4.19030726
6Abnormal number of erythroid precursors (HP:0012131)4.11864836
7Aplastic anemia (HP:0001915)3.66730747
8Abnormality of the preputium (HP:0100587)3.50205849
9Oral leukoplakia (HP:0002745)3.46556546
10Breast hypoplasia (HP:0003187)3.40080660
11Abnormality of chromosome stability (HP:0003220)3.26280233
12Meckel diverticulum (HP:0002245)3.24259638
13Abnormality of the ileum (HP:0001549)3.08385813
14Absent thumb (HP:0009777)2.96860786
15Aplasia/Hypoplasia of the uvula (HP:0010293)2.95652967
16Macrocytic anemia (HP:0001972)2.93733790
17Acute encephalopathy (HP:0006846)2.91139628
18Pallor (HP:0000980)2.88948630
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.87057937
20Duplicated collecting system (HP:0000081)2.84006398
21Type I transferrin isoform profile (HP:0003642)2.79402021
22Myelodysplasia (HP:0002863)2.78749004
23Rough bone trabeculation (HP:0100670)2.78486575
24Abnormality of alanine metabolism (HP:0010916)2.75720868
25Hyperalaninemia (HP:0003348)2.75720868
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.75720868
27Microvesicular hepatic steatosis (HP:0001414)2.72045392
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.70662263
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.69477385
30Premature graying of hair (HP:0002216)2.64893561
31Bone marrow hypocellularity (HP:0005528)2.64396716
32Agnosia (HP:0010524)2.63649035
33Abnormal spermatogenesis (HP:0008669)2.62804365
34Patellar aplasia (HP:0006443)2.61423202
35Increased hepatocellular lipid droplets (HP:0006565)2.61120923
36Abnormality of the pons (HP:0007361)2.61094607
3711 pairs of ribs (HP:0000878)2.60182911
38Pancreatic cysts (HP:0001737)2.59964093
39Progressive macrocephaly (HP:0004481)2.59843589
40Cerebral hypomyelination (HP:0006808)2.58939851
41Abnormality of the renal collecting system (HP:0004742)2.58175549
42Type 2 muscle fiber atrophy (HP:0003554)2.57222790
43Pancytopenia (HP:0001876)2.56599538
443-Methylglutaconic aciduria (HP:0003535)2.52304256
45Small intestinal stenosis (HP:0012848)2.52277665
46Duodenal stenosis (HP:0100867)2.52277665
47Carpal bone hypoplasia (HP:0001498)2.51949502
48Degeneration of anterior horn cells (HP:0002398)2.48903998
49Abnormality of the anterior horn cell (HP:0006802)2.48903998
50Aplasia/Hypoplasia of the patella (HP:0006498)2.46247007
51Increased serum lactate (HP:0002151)2.45836011
52Abnormal lung lobation (HP:0002101)2.43177225
53Supernumerary spleens (HP:0009799)2.43118966
54Impulsivity (HP:0100710)2.42897039
55Colon cancer (HP:0003003)2.41494541
56Muscle fiber atrophy (HP:0100295)2.38089840
57Ectopic kidney (HP:0000086)2.37359829
58Medulloblastoma (HP:0002885)2.33803795
59Selective tooth agenesis (HP:0001592)2.33396475
60Pendular nystagmus (HP:0012043)2.33294967
61Increased CSF lactate (HP:0002490)2.32902224
62Triphalangeal thumb (HP:0001199)2.32722567
63Abnormality of methionine metabolism (HP:0010901)2.31419421
64Abnormality of DNA repair (HP:0003254)2.29410693
65Absent radius (HP:0003974)2.27965164
66Horseshoe kidney (HP:0000085)2.27153385
67Mitochondrial inheritance (HP:0001427)2.27023994
68Sloping forehead (HP:0000340)2.26871920
69Decreased activity of mitochondrial respiratory chain (HP:0008972)2.25867626
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.25867626
71Hypoplasia of the pons (HP:0012110)2.24938396
72Methylmalonic acidemia (HP:0002912)2.24735941
73Clubbing of toes (HP:0100760)2.21805666
74Abnormality of serum amino acid levels (HP:0003112)2.17477045
75Abnormality of the labia minora (HP:0012880)2.17368550
76Cerebral edema (HP:0002181)2.16726378
77Hepatocellular necrosis (HP:0001404)2.15780203
78Absent forearm bone (HP:0003953)2.11949431
79Aplasia involving forearm bones (HP:0009822)2.11949431
80Cellular immunodeficiency (HP:0005374)2.11657635
81Nephroblastoma (Wilms tumor) (HP:0002667)2.11500982
82Cleft eyelid (HP:0000625)2.10645548
83Acute necrotizing encephalopathy (HP:0006965)2.10560310
84Reduced antithrombin III activity (HP:0001976)2.08870377
85Lipid accumulation in hepatocytes (HP:0006561)2.08019205
86Abnormality of the heme biosynthetic pathway (HP:0010472)2.07692895
87Hyperglycinuria (HP:0003108)2.07167229
88Exertional dyspnea (HP:0002875)2.07090847
89Congenital, generalized hypertrichosis (HP:0004540)2.06938937
90True hermaphroditism (HP:0010459)2.06884337
91Ependymoma (HP:0002888)2.03344668
92Thrombocytosis (HP:0001894)2.03277235
93Pancreatic islet-cell hyperplasia (HP:0004510)2.02559899
94Acute lymphatic leukemia (HP:0006721)2.02429697
95Abnormal trabecular bone morphology (HP:0100671)2.01436961
96Hepatic necrosis (HP:0002605)2.01163875
97Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00461488
98Microretrognathia (HP:0000308)2.00337721
99Oligodactyly (hands) (HP:0001180)1.98636173
100Neoplasm of the pancreas (HP:0002894)1.98627483
101Lactic acidosis (HP:0003128)1.98212921
102Bilateral microphthalmos (HP:0007633)1.98125117
103Abnormality of the duodenum (HP:0002246)1.98076632
104Sclerocornea (HP:0000647)1.97682822
105Molar tooth sign on MRI (HP:0002419)1.97662234
106Abnormality of midbrain morphology (HP:0002418)1.97662234
107Embryonal renal neoplasm (HP:0011794)1.97271218
108Tracheoesophageal fistula (HP:0002575)1.95637970
109Facial cleft (HP:0002006)1.95418848
110Type II lissencephaly (HP:0007260)1.93964956
111Lymphoma (HP:0002665)1.93787958
112Neoplasm of the colon (HP:0100273)1.91743813
113Abnormal number of incisors (HP:0011064)1.91202698
114Squamous cell carcinoma (HP:0002860)1.91181068
115CNS hypomyelination (HP:0003429)1.90638323
116Methylmalonic aciduria (HP:0012120)1.89143273
117Neoplasm of the adrenal gland (HP:0100631)1.88572617
118Hyperglycinemia (HP:0002154)1.88480463
119Abnormality of the carotid arteries (HP:0005344)1.88355237
120Abnormal mitochondria in muscle tissue (HP:0008316)1.87216330
121Glioma (HP:0009733)1.87165849
122Pancreatic fibrosis (HP:0100732)1.86951963
123Biliary tract neoplasm (HP:0100574)1.86289885
124Respiratory difficulties (HP:0002880)1.85754976
125Progressive external ophthalmoplegia (HP:0000590)1.85296074
126Hypoplasia of the radius (HP:0002984)1.84766809
127Exercise intolerance (HP:0003546)1.83971879
128Abnormal protein glycosylation (HP:0012346)1.83967789
129Abnormal glycosylation (HP:0012345)1.83967789
130Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83967789
131Abnormal protein N-linked glycosylation (HP:0012347)1.83967789
132Volvulus (HP:0002580)1.83808131
133Abnormality of glycine metabolism (HP:0010895)1.83784115
134Abnormality of serine family amino acid metabolism (HP:0010894)1.83784115
135Hypoplastic pelvis (HP:0008839)1.83240608
136IgM deficiency (HP:0002850)1.82736149
137Multiple enchondromatosis (HP:0005701)1.82589412
138Nephronophthisis (HP:0000090)1.81784315
139Optic nerve coloboma (HP:0000588)1.80780086
140Short thumb (HP:0009778)1.79995654
141Increased serum pyruvate (HP:0003542)1.78191069
142Megaloblastic anemia (HP:0001889)1.77373590
143Renal Fanconi syndrome (HP:0001994)1.75583053
144Abnormality of glycolysis (HP:0004366)1.73997568
145Lethargy (HP:0001254)1.73618402
146Leukodystrophy (HP:0002415)1.72884326
147Progressive inability to walk (HP:0002505)1.71268451

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.39695694
2STK163.74602702
3EIF2AK13.73418365
4WEE13.71017205
5CDC73.14174989
6SRPK13.10203306
7TSSK62.89822782
8EIF2AK32.76474359
9PLK42.49191944
10MKNK12.47052853
11MKNK22.44775844
12VRK22.37939247
13TLK12.36666508
14VRK12.29972107
15FRK2.27871954
16NME22.13018002
17ZAK2.04448045
18BRSK22.00857621
19WNK31.99101718
20INSRR1.98329500
21TTK1.94915223
22CCNB11.88637765
23PLK11.81262086
24PLK31.76049068
25ATR1.69112104
26NEK21.67310047
27ACVR1B1.63503280
28TRIM281.58511313
29DYRK31.41062075
30CDK71.40314710
31IRAK31.36784548
32EIF2AK21.35304270
33AURKB1.33805819
34PASK1.27602930
35CDK81.27568586
36CHEK21.23987871
37CASK1.18463858
38BRSK11.17669288
39NEK11.17279323
40MAP4K21.17099789
41TAF11.15340020
42IRAK41.13115780
43AURKA1.04209186
44PIM21.03882187
45NME11.00224815
46CHEK10.98432900
47TEC0.93554349
48RPS6KB20.91675663
49TXK0.89985688
50WNK40.89547345
51STK30.89514336
52TESK20.85214698
53YES10.83362791
54CDK190.82141765
55ATM0.81979414
56GRK10.81641854
57OXSR10.80224833
58CSNK2A20.79504254
59CLK10.78948351
60PDK40.78300991
61PDK30.78300991
62TGFBR10.77615695
63STK390.75283935
64CSNK2A10.75173137
65DYRK20.73066003
66FLT30.69302251
67PIM10.69023405
68STK40.68611105
69PBK0.68333135
70PNCK0.66929689
71FGFR10.63945731
72BRAF0.62857185
73CDK20.62462029
74EPHA20.61883484
75BRD40.61093178
76CDK40.61081502
77CSNK1G10.60986253
78MAP3K80.60480092
79RPS6KA40.59419647
80AKT30.58276055
81LATS10.57621230
82MAP3K40.57577412
83BCKDK0.55772198
84TNIK0.55381281
85ERBB30.54449891
86PRKCG0.54059381
87ERBB40.53745357
88KIT0.53550113
89CDK10.52513680
90MAP3K120.52436628
91MAP2K70.52000440
92PRKCI0.47740369
93RPS6KA50.46337446
94CSNK1G20.42218750
95CSNK1G30.41816810
96DAPK10.41377630
97ALK0.40992855
98MST40.40919497
99BTK0.39964582
100MAPKAPK50.39246959
101PAK40.38169738
102FGFR20.37898927
103PAK10.37744114
104ADRBK20.36878941
105TIE10.35465772
106STK100.35154505
107PDK20.33825780
108BMPR1B0.33404911
109CSNK1A1L0.33391435
110MAP4K10.33050502
111NEK60.31666153
112STK38L0.30921950
113RPS6KB10.30181177
114PLK20.29803583
115LYN0.29406786
116PRKDC0.27298758
117TAOK20.26898171
118NUAK10.26780954
119PINK10.26628634
120BCR0.26329302
121MAP2K60.25833192
122TESK10.24514070
123NLK0.23604817
124CSNK1D0.23298498
125PRKCE0.22873489
126MAP3K60.22690483
127CDK30.22585721
128CSNK1A10.22533333
129PRKACB0.22345121
130IRAK10.22098211
131CSNK1E0.21954524
132SCYL20.21099620
133ZAP700.20151770

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.67279941
2Mismatch repair_Homo sapiens_hsa034303.99103697
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.98627195
4Ribosome_Homo sapiens_hsa030103.93963738
5RNA polymerase_Homo sapiens_hsa030203.88273086
6Proteasome_Homo sapiens_hsa030503.69188754
7Homologous recombination_Homo sapiens_hsa034403.24859145
8Spliceosome_Homo sapiens_hsa030403.20454112
9RNA transport_Homo sapiens_hsa030132.90651234
10Nucleotide excision repair_Homo sapiens_hsa034202.89374225
11Base excision repair_Homo sapiens_hsa034102.82094924
12Pyrimidine metabolism_Homo sapiens_hsa002402.76551438
13Fanconi anemia pathway_Homo sapiens_hsa034602.74221424
14Basal transcription factors_Homo sapiens_hsa030222.49693878
15One carbon pool by folate_Homo sapiens_hsa006702.43167104
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.41479329
17Non-homologous end-joining_Homo sapiens_hsa034502.28525686
18Cell cycle_Homo sapiens_hsa041102.25091339
19RNA degradation_Homo sapiens_hsa030182.02151497
20Propanoate metabolism_Homo sapiens_hsa006401.76707450
21Purine metabolism_Homo sapiens_hsa002301.71847437
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64195727
23mRNA surveillance pathway_Homo sapiens_hsa030151.62274699
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52356787
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46222081
26Protein export_Homo sapiens_hsa030601.43190199
27Caffeine metabolism_Homo sapiens_hsa002321.36911666
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35386294
29Pyruvate metabolism_Homo sapiens_hsa006201.34162866
30p53 signaling pathway_Homo sapiens_hsa041151.29509689
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26905212
32Huntingtons disease_Homo sapiens_hsa050161.20203849
33Epstein-Barr virus infection_Homo sapiens_hsa051691.16686782
34Parkinsons disease_Homo sapiens_hsa050121.14038020
35Oxidative phosphorylation_Homo sapiens_hsa001901.13814447
36Steroid biosynthesis_Homo sapiens_hsa001001.04266111
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02747387
38Systemic lupus erythematosus_Homo sapiens_hsa053221.02008953
39Vitamin B6 metabolism_Homo sapiens_hsa007500.95555288
40Butanoate metabolism_Homo sapiens_hsa006500.92617115
41Maturity onset diabetes of the young_Homo sapiens_hsa049500.85847718
42Herpes simplex infection_Homo sapiens_hsa051680.85644541
43Nitrogen metabolism_Homo sapiens_hsa009100.84812952
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.83745527
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79972548
46Oocyte meiosis_Homo sapiens_hsa041140.79511260
47Tryptophan metabolism_Homo sapiens_hsa003800.79118971
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77343407
49Antigen processing and presentation_Homo sapiens_hsa046120.74660335
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71648679
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68100514
52Pentose phosphate pathway_Homo sapiens_hsa000300.67561881
53Cardiac muscle contraction_Homo sapiens_hsa042600.66659368
54Fatty acid elongation_Homo sapiens_hsa000620.65850422
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65003245
56Primary immunodeficiency_Homo sapiens_hsa053400.64945681
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64347420
58Peroxisome_Homo sapiens_hsa041460.64225084
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62494101
60Linoleic acid metabolism_Homo sapiens_hsa005910.62453720
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60978190
62Viral carcinogenesis_Homo sapiens_hsa052030.60129479
63Folate biosynthesis_Homo sapiens_hsa007900.56734465
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56200692
65Fatty acid metabolism_Homo sapiens_hsa012120.55816150
66Fatty acid degradation_Homo sapiens_hsa000710.53849655
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53469095
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52708008
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52103865
70Sulfur metabolism_Homo sapiens_hsa009200.50945693
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50769081
72Vitamin digestion and absorption_Homo sapiens_hsa049770.50600478
73Alzheimers disease_Homo sapiens_hsa050100.48377751
74Ether lipid metabolism_Homo sapiens_hsa005650.47059541
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.46562921
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.46549231
77Thyroid cancer_Homo sapiens_hsa052160.45985476
78Glutathione metabolism_Homo sapiens_hsa004800.45679727
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44995404
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43371487
81Lysine degradation_Homo sapiens_hsa003100.42589696
82Alcoholism_Homo sapiens_hsa050340.42586535
83HTLV-I infection_Homo sapiens_hsa051660.42459461
84Biosynthesis of amino acids_Homo sapiens_hsa012300.42034414
85N-Glycan biosynthesis_Homo sapiens_hsa005100.40220496
86Legionellosis_Homo sapiens_hsa051340.39799401
87Retinol metabolism_Homo sapiens_hsa008300.39680641
88Measles_Homo sapiens_hsa051620.39284767
89Sulfur relay system_Homo sapiens_hsa041220.39238819
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38851527
91Selenocompound metabolism_Homo sapiens_hsa004500.38233966
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37944590
93Metabolic pathways_Homo sapiens_hsa011000.37355461
94Arachidonic acid metabolism_Homo sapiens_hsa005900.36640957
95Arginine and proline metabolism_Homo sapiens_hsa003300.35999570
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35674695
97Hematopoietic cell lineage_Homo sapiens_hsa046400.33279380
98beta-Alanine metabolism_Homo sapiens_hsa004100.32410077
99Taste transduction_Homo sapiens_hsa047420.32329552
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31651269
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31203094
102Nicotine addiction_Homo sapiens_hsa050330.31140474
103Allograft rejection_Homo sapiens_hsa053300.30987149
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29400005
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29236044
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.29142155
107Olfactory transduction_Homo sapiens_hsa047400.28474527
108Fat digestion and absorption_Homo sapiens_hsa049750.27742207
109Asthma_Homo sapiens_hsa053100.27702347
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27232483
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.26828282
112Chemical carcinogenesis_Homo sapiens_hsa052040.26141797
113Phototransduction_Homo sapiens_hsa047440.25571076
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.25358427
115Renin-angiotensin system_Homo sapiens_hsa046140.23643472
116TGF-beta signaling pathway_Homo sapiens_hsa043500.23282816
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.23086928
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20406500
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20291898
120Autoimmune thyroid disease_Homo sapiens_hsa053200.18706534
121Influenza A_Homo sapiens_hsa051640.18440504
122Apoptosis_Homo sapiens_hsa042100.17909894
123Type I diabetes mellitus_Homo sapiens_hsa049400.16431004
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16171660
125Fructose and mannose metabolism_Homo sapiens_hsa000510.14957428
126Regulation of autophagy_Homo sapiens_hsa041400.14352961
127Other glycan degradation_Homo sapiens_hsa005110.12991669
128Carbon metabolism_Homo sapiens_hsa012000.12931065
129Hepatitis B_Homo sapiens_hsa051610.10794708
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.10786969
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.09934687
132Graft-versus-host disease_Homo sapiens_hsa053320.08608423
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.08605702
134Galactose metabolism_Homo sapiens_hsa000520.08046407
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07928095
136Sphingolipid metabolism_Homo sapiens_hsa006000.06926853
137Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.06861139
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.06496594
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.05945977
140Small cell lung cancer_Homo sapiens_hsa052220.05704948
141Shigellosis_Homo sapiens_hsa051310.04906536
142MicroRNAs in cancer_Homo sapiens_hsa052060.04367372
143Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.02990597
144HIF-1 signaling pathway_Homo sapiens_hsa040660.02217215

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