WDR13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. A similar protein in mouse is thought to be a negative regulator of the pancreatic beta cell proliferation. Mice lacking this gene exhibit increased pancreatic islet mass and higher serum insulin levels, and are mildly obese. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.96887408
2locomotory exploration behavior (GO:0035641)5.78064491
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.68744141
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.29174582
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.15127045
6vocalization behavior (GO:0071625)5.09553573
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.92061033
8layer formation in cerebral cortex (GO:0021819)4.81335623
9synaptic vesicle exocytosis (GO:0016079)4.73787170
10regulation of synapse structural plasticity (GO:0051823)4.69739279
11glutamate secretion (GO:0014047)4.68309936
12regulation of glutamate receptor signaling pathway (GO:1900449)4.65175343
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.58936433
14regulation of synaptic vesicle exocytosis (GO:2000300)4.57926481
15exploration behavior (GO:0035640)4.42154298
16dendritic spine morphogenesis (GO:0060997)4.37054880
17protein localization to synapse (GO:0035418)4.23618257
18regulation of long-term neuronal synaptic plasticity (GO:0048169)4.23085131
19regulation of neuronal synaptic plasticity (GO:0048168)4.18250068
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.06833405
21proline transport (GO:0015824)4.06408862
22neurotransmitter secretion (GO:0007269)4.04721319
23regulation of synaptic vesicle transport (GO:1902803)4.03937062
24neurotransmitter-gated ion channel clustering (GO:0072578)4.03312628
25neuron cell-cell adhesion (GO:0007158)3.84203472
26activation of protein kinase A activity (GO:0034199)3.73478800
27gamma-aminobutyric acid transport (GO:0015812)3.68011784
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.65764563
29sodium ion export (GO:0071436)3.65559176
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.61879810
31synaptic transmission, glutamatergic (GO:0035249)3.60914466
32regulation of dendritic spine morphogenesis (GO:0061001)3.56330397
33cellular potassium ion homeostasis (GO:0030007)3.56053744
34dendrite morphogenesis (GO:0048813)3.55571660
35long-term memory (GO:0007616)3.53333129
36glutamate receptor signaling pathway (GO:0007215)3.51044104
37neuronal action potential propagation (GO:0019227)3.48755160
38positive regulation of membrane potential (GO:0045838)3.48136437
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.45591869
40neuromuscular process controlling balance (GO:0050885)3.39379853
41neuron recognition (GO:0008038)3.35907971
42neuron-neuron synaptic transmission (GO:0007270)3.33132664
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.28897218
44G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.24951639
45positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.24887499
46regulation of postsynaptic membrane potential (GO:0060078)3.24682635
47cell communication by electrical coupling (GO:0010644)3.22886361
48auditory behavior (GO:0031223)3.22741388
49positive regulation of synapse maturation (GO:0090129)3.21966860
50regulation of synaptic plasticity (GO:0048167)3.20896445
51prepulse inhibition (GO:0060134)3.16526639
52positive regulation of synaptic transmission, GABAergic (GO:0032230)3.15705067
53axonal fasciculation (GO:0007413)3.15129386
54glycine transport (GO:0015816)3.15119514
55neurotransmitter transport (GO:0006836)3.15089526
56regulation of ARF protein signal transduction (GO:0032012)3.14420432
57dendritic spine organization (GO:0097061)3.11838219
58transmission of nerve impulse (GO:0019226)3.09732823
59response to auditory stimulus (GO:0010996)3.08248447
60regulation of dendritic spine development (GO:0060998)3.02827080
61regulation of neurotransmitter secretion (GO:0046928)3.01944779
62vesicle transport along microtubule (GO:0047496)3.00292845
63positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.99449004
64regulation of synaptic transmission, glutamatergic (GO:0051966)2.96867131
65postsynaptic membrane organization (GO:0001941)2.96628544
66regulation of neurotransmitter levels (GO:0001505)2.96270619
67positive regulation of dendritic spine development (GO:0060999)2.96246821
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.95933028
69synaptic vesicle endocytosis (GO:0048488)2.95790928
70positive regulation of neurotransmitter secretion (GO:0001956)2.95503097
71neuronal ion channel clustering (GO:0045161)2.93890286
72long-term synaptic potentiation (GO:0060291)2.90878340
73positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.90406501
74regulation of female receptivity (GO:0045924)2.89830410
75cell migration in hindbrain (GO:0021535)2.89693410
76clathrin coat assembly (GO:0048268)2.87156135
77dopamine receptor signaling pathway (GO:0007212)2.85389966
78regulation of vesicle fusion (GO:0031338)2.83291450
79positive regulation of neurotransmitter transport (GO:0051590)2.82622721
80membrane depolarization (GO:0051899)2.81819131
81membrane depolarization during action potential (GO:0086010)2.80731545
82organelle transport along microtubule (GO:0072384)2.80096646
83innervation (GO:0060384)2.78718226
84regulation of neurotransmitter transport (GO:0051588)2.77600139
85synapse assembly (GO:0007416)2.77529177
86establishment of nucleus localization (GO:0040023)2.76371054
87axonemal dynein complex assembly (GO:0070286)2.76253857
88alanine transport (GO:0032328)2.75198567
89mating behavior (GO:0007617)2.72724991
90regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.72513399
91positive regulation of dendritic spine morphogenesis (GO:0061003)2.72151225
92learning (GO:0007612)2.71661423
93cilium or flagellum-dependent cell motility (GO:0001539)2.70835072
94central nervous system projection neuron axonogenesis (GO:0021952)2.70776208
95membrane hyperpolarization (GO:0060081)2.70444470
96intraspecies interaction between organisms (GO:0051703)2.70003808
97social behavior (GO:0035176)2.70003808
98pyrimidine nucleobase catabolic process (GO:0006208)2.69260450
99cell communication involved in cardiac conduction (GO:0086065)2.69015928
100synapse organization (GO:0050808)2.68914076
101adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.66902616
102potassium ion import (GO:0010107)2.66823505
103motile cilium assembly (GO:0044458)2.64547037
104axoneme assembly (GO:0035082)2.57772698
105behavioral response to nicotine (GO:0035095)2.56592896
106ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.54598721
107positive regulation of protein kinase C signaling (GO:0090037)2.50900584
108regulation of hydrogen peroxide metabolic process (GO:0010310)2.44516824
109regulation of skeletal muscle contraction (GO:0014819)2.44495566
110macroautophagy (GO:0016236)2.41879305
111epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.39225645
112neurotransmitter catabolic process (GO:0042135)2.35087683
113positive regulation of triglyceride biosynthetic process (GO:0010867)2.29473342
114response to misfolded protein (GO:0051788)2.26980028
115cilium movement (GO:0003341)2.26465988
116response to gravity (GO:0009629)2.25662610
117positive regulation of CREB transcription factor activity (GO:0032793)2.20742083
118neurotransmitter metabolic process (GO:0042133)2.20186414
119negative regulation of synaptic transmission, GABAergic (GO:0032229)2.18279115
120positive regulation of fatty acid beta-oxidation (GO:0032000)2.11821102
121regulation of voltage-gated calcium channel activity (GO:1901385)2.11350437
122regulation of synapse maturation (GO:0090128)2.10988268
123autophagic vacuole fusion (GO:0000046)2.08283941
124opioid receptor signaling pathway (GO:0038003)2.07368681
125neurotransmitter biosynthetic process (GO:0042136)2.05103481
126urinary tract smooth muscle contraction (GO:0014848)2.02146010
127phosphatidylglycerol biosynthetic process (GO:0006655)2.01974590
128axon ensheathment in central nervous system (GO:0032291)2.01892357
129central nervous system myelination (GO:0022010)2.01892357
130regulation of respiratory system process (GO:0044065)1.97415429
131positive regulation of sodium ion transmembrane transport (GO:1902307)1.96076676
132regulation of triglyceride biosynthetic process (GO:0010866)1.94786886
133creatine metabolic process (GO:0006600)1.92748623
134epithelial cilium movement (GO:0003351)1.92283695
135positive regulation of sodium ion transport (GO:0010765)1.92274074
136positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)1.90986178
137neuromuscular synaptic transmission (GO:0007274)1.88786034
138positive regulation of lipoprotein lipase activity (GO:0051006)1.87191865
139positive regulation of triglyceride lipase activity (GO:0061365)1.87191865
140positive regulation of fatty acid oxidation (GO:0046321)1.86889743
141dermatan sulfate metabolic process (GO:0030205)1.86654543
142regulation of membrane repolarization (GO:0060306)1.86440599
143neuronal action potential (GO:0019228)1.85014489
144cellular response to ATP (GO:0071318)1.84002643
145protein localization to cilium (GO:0061512)1.83707263
146left/right pattern formation (GO:0060972)1.83640880
147cerebellar granule cell differentiation (GO:0021707)1.82323542
148serotonin metabolic process (GO:0042428)1.81852044
149regulation of sodium ion transmembrane transporter activity (GO:2000649)1.81592480
150regulation of microtubule-based movement (GO:0060632)1.81301574
151regulation of calcineurin-NFAT signaling cascade (GO:0070884)1.81223079
152negative regulation of protein localization to cell surface (GO:2000009)1.80984562
153one-carbon compound transport (GO:0019755)1.80696810
154adaptation of signaling pathway (GO:0023058)1.80372353
155positive regulation of triglyceride metabolic process (GO:0090208)1.79232228
156positive regulation of dendrite development (GO:1900006)1.79117412
157startle response (GO:0001964)1.78259028
158negative regulation of calcium ion transmembrane transport (GO:1903170)1.76344296
159negative regulation of calcium ion transmembrane transporter activity (GO:1901020)1.76344296
160primary amino compound metabolic process (GO:1901160)1.76050596
161glycerophospholipid catabolic process (GO:0046475)1.75181487

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.17135134
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.88512586
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.85073257
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.83253848
5GBX2_23144817_ChIP-Seq_PC3_Human2.81453285
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.79846483
7DROSHA_22980978_ChIP-Seq_HELA_Human2.68650838
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.62731085
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58078249
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58078249
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49523460
12REST_21632747_ChIP-Seq_MESCs_Mouse2.47111562
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45852659
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45610872
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39495409
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.37499978
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33902996
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29878670
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.28678147
20CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.25624985
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.21172114
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.20199576
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19797201
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.10118726
25LXR_22292898_ChIP-Seq_THP-1_Human2.04591310
26* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03142496
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.02042455
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.92209532
29AR_21572438_ChIP-Seq_LNCaP_Human1.84030509
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83377481
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75139901
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.69479176
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.65696433
34* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65472450
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64975862
36* P68_20966046_ChIP-Seq_HELA_Human1.62345448
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62245639
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.56977385
39BCL6_27268052_Chip-Seq_Bcells_Human1.55991103
40PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.51095717
41SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45795209
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39183541
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38961809
44KDM2B_26808549_Chip-Seq_K562_Human1.38585734
45ZNF274_21170338_ChIP-Seq_K562_Hela1.37838175
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37362264
47WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36954544
48BCOR_27268052_Chip-Seq_Bcells_Human1.36555633
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36428046
50* SMAD4_21799915_ChIP-Seq_A2780_Human1.35307807
51RING1B_27294783_Chip-Seq_ESCs_Mouse1.33563221
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33144926
53* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32819819
54SMC4_20622854_ChIP-Seq_HELA_Human1.32293421
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.32197042
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.31926779
57E2F1_20622854_ChIP-Seq_HELA_Human1.29870884
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28974776
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.28816051
60SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.28167211
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27638328
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27618905
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26883752
64* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23354106
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22312679
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21395305
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20233837
68RAD21_21589869_ChIP-Seq_MESCs_Mouse1.19426536
69TP63_22573176_ChIP-Seq_HFKS_Human1.19382674
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.19232802
71* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18174835
72AR_19668381_ChIP-Seq_PC3_Human1.17204087
73CTCF_20526341_ChIP-Seq_ESCs_Human1.16945487
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16672870
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16226497
76PHF8_20622854_ChIP-Seq_HELA_Human1.15978236
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13244971
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13206947
79AHR_22903824_ChIP-Seq_MCF-7_Human1.11581794
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11452670
81RING1B_27294783_Chip-Seq_NPCs_Mouse1.11197227
82ESR1_21235772_ChIP-Seq_MCF-7_Human1.11122095
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11044935
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.10251596
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.10151409
86SA1_27219007_Chip-Seq_Bcells_Human1.09943464
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.09359293
88AR_25329375_ChIP-Seq_VCAP_Human1.08366849
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07323473
90OCT4_19829295_ChIP-Seq_ESCs_Human1.07202660
91YY1_22570637_ChIP-Seq_MALME-3M_Human1.07163115
92P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06433290
93TAF15_26573619_Chip-Seq_HEK293_Human1.06001994
94* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05073013
95RACK7_27058665_Chip-Seq_MCF-7_Human1.04384295
96STAT3_23295773_ChIP-Seq_U87_Human1.02881154
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01762342
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01405292
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01250266
100YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00707563
101CREB1_26743006_Chip-Seq_LNCaP_Human1.00623785
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00544772
103CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00284102
104SMAD4_21741376_ChIP-Seq_HESCs_Human0.99542961
105ERA_21632823_ChIP-Seq_H3396_Human0.98182070
106KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97334904
107* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97318193
108SMAD_19615063_ChIP-ChIP_OVARY_Human0.96967723
109* GATA1_19941827_ChIP-Seq_MEL_Mouse0.96634855
110ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96014337
111P300_19829295_ChIP-Seq_ESCs_Human0.95717305
112SMAD3_21741376_ChIP-Seq_HESCs_Human0.95676410
113SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95410790
114UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94944536
115KLF4_19829295_ChIP-Seq_ESCs_Human0.94504346
116TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94315035
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94074559
118PIAS1_25552417_ChIP-Seq_VCAP_Human0.93346903
119OCT4_20526341_ChIP-Seq_ESCs_Human0.93330495
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93305363
121SMAD3_21741376_ChIP-Seq_ESCs_Human0.92896543
122STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92794670
123ELK3_25401928_ChIP-Seq_HUVEC_Human0.92559042
124GATA2_21666600_ChIP-Seq_HMVEC_Human0.92515410
125EP300_21415370_ChIP-Seq_HL-1_Mouse0.92368177
126KDM2B_26808549_Chip-Seq_DND41_Human0.92199115
127TP53_16413492_ChIP-PET_HCT116_Human0.91950979
128E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91926353
129STAT1_20625510_ChIP-Seq_HELA_Human0.91807246
130DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91788251
131TP53_20018659_ChIP-ChIP_R1E_Mouse0.91706953
132TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.91570741
133NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91373158
134GATA1_19941826_ChIP-Seq_K562_Human0.91319129
135PPARA_22158963_ChIP-Seq_LIVER_Mouse0.91288188
136MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91257870
137TCF4_23295773_ChIP-Seq_U87_Human0.90909413
138ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90557068
139P300_27268052_Chip-Seq_Bcells_Human0.89910598
140TP53_23651856_ChIP-Seq_MEFs_Mouse0.89373976
141SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88829079
142TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88781834
143TET1_21490601_ChIP-Seq_MESCs_Mouse0.88718281
144PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87998050
145CTCF_27219007_Chip-Seq_Bcells_Human0.87497355
146SMC3_22415368_ChIP-Seq_MEFs_Mouse0.87350508
147TAF2_19829295_ChIP-Seq_ESCs_Human0.86908529
148* RARB_24833708_ChIP-Seq_LIVER_Mouse0.86622603
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.86278169
150MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.85987027
151CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85874152
152BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85829744
153RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85206757
154ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85057417
155RXR_22108803_ChIP-Seq_LS180_Human0.84807873
156CBX2_27304074_Chip-Seq_ESCs_Mouse0.84605918
157ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83056564
158GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82734228
159OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82667494

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.92390702
2MP0003635_abnormal_synaptic_transmissio4.15346930
3MP0004270_analgesia3.92152528
4MP0003880_abnormal_central_pattern3.88854493
5MP0002063_abnormal_learning/memory/cond3.36573604
6MP0009745_abnormal_behavioral_response3.24251742
7MP0002822_catalepsy2.92467291
8MP0002064_seizures2.91518637
9MP0005423_abnormal_somatic_nervous2.90478953
10MP0001968_abnormal_touch/_nociception2.65596139
11MP0002653_abnormal_ependyma_morphology2.64710462
12MP0002572_abnormal_emotion/affect_behav2.63185792
13MP0009046_muscle_twitch2.62990020
14MP0009780_abnormal_chondrocyte_physiolo2.62682026
15MP0002734_abnormal_mechanical_nocicepti2.56244557
16MP0001486_abnormal_startle_reflex2.47049004
17MP0002909_abnormal_adrenal_gland2.42121007
18MP0002272_abnormal_nervous_system2.27561441
19MP0003329_amyloid_beta_deposits2.15902947
20MP0002733_abnormal_thermal_nociception1.98534104
21MP0004858_abnormal_nervous_system1.96866145
22MP0001440_abnormal_grooming_behavior1.96237646
23MP0008569_lethality_at_weaning1.93245042
24MP0002735_abnormal_chemical_nociception1.92945585
25MP0001501_abnormal_sleep_pattern1.91952888
26MP0002736_abnormal_nociception_after1.90954364
27MP0000778_abnormal_nervous_system1.90950936
28MP0004811_abnormal_neuron_physiology1.86322006
29MP0001970_abnormal_pain_threshold1.84870363
30MP0004885_abnormal_endolymph1.73685250
31MP0002557_abnormal_social/conspecific_i1.72240768
32MP0004924_abnormal_behavior1.71304671
33MP0005386_behavior/neurological_phenoty1.71304671
34MP0002067_abnormal_sensory_capabilities1.71264926
35MP0003879_abnormal_hair_cell1.67806858
36MP0002184_abnormal_innervation1.67366057
37MP0000569_abnormal_digit_pigmentation1.66730969
38MP0000955_abnormal_spinal_cord1.57255084
39MP0002876_abnormal_thyroid_physiology1.54879960
40MP0008875_abnormal_xenobiotic_pharmacok1.53610939
41MP0005670_abnormal_white_adipose1.52260281
42MP0003633_abnormal_nervous_system1.44271933
43MP0005646_abnormal_pituitary_gland1.43716254
44MP0000751_myopathy1.42129431
45MP0005058_abnormal_lysosome_morphology1.40702616
46MP0003646_muscle_fatigue1.39795096
47MP0002882_abnormal_neuron_morphology1.36906341
48MP0002066_abnormal_motor_capabilities/c1.36435330
49MP0009840_abnormal_foam_cell1.33985325
50MP0001986_abnormal_taste_sensitivity1.27914589
51MP0008961_abnormal_basal_metabolism1.27300202
52MP0001984_abnormal_olfaction1.26331901
53MP0002332_abnormal_exercise_endurance1.21334293
54MP0003045_fibrosis1.19764568
55MP0010234_abnormal_vibrissa_follicle1.19651766
56MP0003787_abnormal_imprinting1.19249714
57MP0005645_abnormal_hypothalamus_physiol1.18080023
58MP0001502_abnormal_circadian_rhythm1.16981040
59MP0004130_abnormal_muscle_cell1.16580546
60MP0006276_abnormal_autonomic_nervous1.16332827
61MP0010329_abnormal_lipoprotein_level1.15287804
62MP0003631_nervous_system_phenotype1.14775042
63MP0005083_abnormal_biliary_tract1.13845373
64MP0003690_abnormal_glial_cell1.12737672
65MP0002837_dystrophic_cardiac_calcinosis1.12174747
66MP0000681_abnormal_thyroid_gland1.10490559
67MP0001958_emphysema1.09685397
68MP0003075_altered_response_to1.09379420
69MP0000604_amyloidosis1.09151092
70MP0002152_abnormal_brain_morphology1.09117497
71MP0005365_abnormal_bile_salt1.08134242
72MP0000749_muscle_degeneration1.06995755
73MP0000013_abnormal_adipose_tissue1.06853505
74MP0002249_abnormal_larynx_morphology1.06782581
75MP0003183_abnormal_peptide_metabolism1.05420223
76MP0000230_abnormal_systemic_arterial1.05247577
77MP0004085_abnormal_heartbeat1.04507511
78MP0005595_abnormal_vascular_smooth1.00240377
79MP0005448_abnormal_energy_balance0.99743669
80MP0005535_abnormal_body_temperature0.99163122
81MP0003634_abnormal_glial_cell0.98773096
82MP0003283_abnormal_digestive_organ0.97942572
83MP0002069_abnormal_eating/drinking_beha0.97353627
84MP0003279_aneurysm0.96997662
85MP0002638_abnormal_pupillary_reflex0.96479580
86MP0008874_decreased_physiological_sensi0.96342851
87MP0000750_abnormal_muscle_regeneration0.95390821
88MP0003172_abnormal_lysosome_physiology0.95229603
89MP0003011_delayed_dark_adaptation0.94827161
90MP0001905_abnormal_dopamine_level0.94316196
91MP0000920_abnormal_myelination0.93807444
92MP0001177_atelectasis0.92306680
93MP0002090_abnormal_vision0.90319038
94MP0004215_abnormal_myocardial_fiber0.89875084
95MP0004510_myositis0.89844846
96MP0002229_neurodegeneration0.89254491
97MP0002118_abnormal_lipid_homeostasis0.86972411
98MP0000026_abnormal_inner_ear0.86328635
99MP0004133_heterotaxia0.85131113
100MP0002933_joint_inflammation0.84578368
101MP0003137_abnormal_impulse_conducting0.84231682
102MP0003136_yellow_coat_color0.83356901
103MP0001765_abnormal_ion_homeostasis0.82222260
104MP0004147_increased_porphyrin_level0.81200918
105MP0009764_decreased_sensitivity_to0.81133359
106MP0000678_abnormal_parathyroid_gland0.81121486
107MP0001529_abnormal_vocalization0.79296358
108MP0004142_abnormal_muscle_tone0.77673825
109MP0005167_abnormal_blood-brain_barrier0.77411679
110MP0003632_abnormal_nervous_system0.76612888
111MP0005187_abnormal_penis_morphology0.76108825
112MP0008872_abnormal_physiological_respon0.75662789
113MP0004145_abnormal_muscle_electrophysio0.75333582
114MP0010386_abnormal_urinary_bladder0.74975633
115MP0003122_maternal_imprinting0.73395046
116MP0008775_abnormal_heart_ventricle0.72328255
117MP0004036_abnormal_muscle_relaxation0.72177429
118MP0004484_altered_response_of0.69991845
119MP0000631_abnormal_neuroendocrine_gland0.65804659
120MP0004742_abnormal_vestibular_system0.64612433
121MP0001963_abnormal_hearing_physiology0.64553420
122MP0004043_abnormal_pH_regulation0.63683513
123MP0001664_abnormal_digestion0.62159232
124MP0001348_abnormal_lacrimal_gland0.60471634
125MP0005551_abnormal_eye_electrophysiolog0.59524730
126MP0002234_abnormal_pharynx_morphology0.59072416
127MP0002752_abnormal_somatic_nervous0.58662372
128MP0001188_hyperpigmentation0.58109103
129MP0005620_abnormal_muscle_contractility0.57985606
130MP0005623_abnormal_meninges_morphology0.56427369
131MP0001299_abnormal_eye_distance/0.56426991
132MP0000747_muscle_weakness0.53333575
133MP0004233_abnormal_muscle_weight0.52674477
134MP0001943_abnormal_respiration0.52536274
135MP0003303_peritoneal_inflammation0.51741701
136MP0003861_abnormal_nervous_system0.51398891

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.57206151
2Focal motor seizures (HP:0011153)5.91110207
3Visual hallucinations (HP:0002367)4.95017137
4Focal seizures (HP:0007359)4.94488769
5Supranuclear gaze palsy (HP:0000605)4.21104601
6Epileptic encephalopathy (HP:0200134)3.90427223
7Ankle clonus (HP:0011448)3.87758188
8Action tremor (HP:0002345)3.86516533
9Papilledema (HP:0001085)3.84740544
10Mutism (HP:0002300)3.55144474
11Progressive cerebellar ataxia (HP:0002073)3.49372221
12Abnormal respiratory epithelium morphology (HP:0012253)3.42219450
13Abnormal respiratory motile cilium morphology (HP:0005938)3.42219450
14Dynein arm defect of respiratory motile cilia (HP:0012255)3.38211318
15Absent/shortened dynein arms (HP:0200106)3.38211318
16J-shaped sella turcica (HP:0002680)3.37471202
17Atonic seizures (HP:0010819)3.35522635
18Poor eye contact (HP:0000817)3.31128183
19Absence seizures (HP:0002121)3.28031110
20Broad-based gait (HP:0002136)3.26162205
21Depression (HP:0000716)3.24564062
22Generalized tonic-clonic seizures (HP:0002069)3.20412078
23Neurofibrillary tangles (HP:0002185)3.16742369
24Febrile seizures (HP:0002373)3.13304991
25Impaired vibration sensation in the lower limbs (HP:0002166)3.11854463
26Abnormal social behavior (HP:0012433)3.11155145
27Impaired social interactions (HP:0000735)3.11155145
28Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.10461208
29Abnormal ciliary motility (HP:0012262)3.08800833
30Torticollis (HP:0000473)3.08651527
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.07284667
32Urinary bladder sphincter dysfunction (HP:0002839)3.05294538
33Postural instability (HP:0002172)3.00524328
34Cerebral inclusion bodies (HP:0100314)3.00092153
35Anxiety (HP:0000739)2.97922696
36Dialeptic seizures (HP:0011146)2.97548697
37Urinary urgency (HP:0000012)2.91215541
38Decreased circulating renin level (HP:0003351)2.88257081
39Abnormal respiratory motile cilium physiology (HP:0012261)2.86042678
40Dysmetria (HP:0001310)2.84742755
41Intention tremor (HP:0002080)2.83446974
42Dysostosis multiplex (HP:0000943)2.82330109
43Dysdiadochokinesis (HP:0002075)2.81571869
44Megalencephaly (HP:0001355)2.77063857
45Focal dystonia (HP:0004373)2.76006367
46Abnormal eating behavior (HP:0100738)2.72239013
47Abnormality of the lower motor neuron (HP:0002366)2.71975309
48Abnormality of polysaccharide metabolism (HP:0011012)2.68716060
49Abnormality of glycosaminoglycan metabolism (HP:0004371)2.68716060
50Abnormality of mucopolysaccharide metabolism (HP:0011020)2.68716060
51Drooling (HP:0002307)2.67834153
52Excessive salivation (HP:0003781)2.67834153
53Amblyopia (HP:0000646)2.63015511
54Ventricular fibrillation (HP:0001663)2.62996413
55Hyperventilation (HP:0002883)2.62189442
56Spastic gait (HP:0002064)2.60051605
57Genetic anticipation (HP:0003743)2.59231725
58Gaze-evoked nystagmus (HP:0000640)2.57998310
59Craniofacial dystonia (HP:0012179)2.55932459
60Increased neuronal autofluorescent lipopigment (HP:0002074)2.55291653
61Truncal ataxia (HP:0002078)2.55257915
62Progressive inability to walk (HP:0002505)2.54656301
63Abnormality of the nasal mucosa (HP:0000433)2.53012755
64Cystic liver disease (HP:0006706)2.49760574
65Stereotypic behavior (HP:0000733)2.48597592
66Rhinitis (HP:0012384)2.48128987
67Bundle branch block (HP:0011710)2.46518915
68Urinary glycosaminoglycan excretion (HP:0003541)2.46043225
69Mucopolysacchariduria (HP:0008155)2.46043225
70Hemiparesis (HP:0001269)2.43638952
71Molar tooth sign on MRI (HP:0002419)2.42455599
72Abnormality of midbrain morphology (HP:0002418)2.42455599
73Insomnia (HP:0100785)2.42086753
74Limb dystonia (HP:0002451)2.41817311
75Diplopia (HP:0000651)2.41497639
76Abnormality of binocular vision (HP:0011514)2.41497639
77Abnormality of the corticospinal tract (HP:0002492)2.41227591
78Amyotrophic lateral sclerosis (HP:0007354)2.39665559
79Abnormality of glycolipid metabolism (HP:0010969)2.36320161
80Abnormality of liposaccharide metabolism (HP:0010968)2.36320161
81Abnormality of glycosphingolipid metabolism (HP:0004343)2.36320161
82Bradykinesia (HP:0002067)2.36298662
83Increased cerebral lipofuscin (HP:0011813)2.35653506
84Nasal polyposis (HP:0100582)2.34820866
85Termporal pattern (HP:0011008)2.34532815
86Insidious onset (HP:0003587)2.34532815
87Lower limb muscle weakness (HP:0007340)2.34512287
88Inappropriate behavior (HP:0000719)2.33454288
89Pancreatic cysts (HP:0001737)2.33412531
90Hemiplegia (HP:0002301)2.31798627
91True hermaphroditism (HP:0010459)2.30075563
92Akinesia (HP:0002304)2.30022193
93Agitation (HP:0000713)2.27839634
94Impaired smooth pursuit (HP:0007772)2.27315753
95EEG with generalized epileptiform discharges (HP:0011198)2.26813841
96Apathy (HP:0000741)2.26500292
97Epileptiform EEG discharges (HP:0011182)2.25775635
98Hypsarrhythmia (HP:0002521)2.24259451
99Obstructive sleep apnea (HP:0002870)2.22028305
100Scanning speech (HP:0002168)2.21968532
101Mesangial abnormality (HP:0001966)2.20845548
102Stridor (HP:0010307)2.20375458
103Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.17076746
104Pointed chin (HP:0000307)2.16531097
105Muscle fiber splitting (HP:0003555)2.16369557
106Clonus (HP:0002169)2.13501010
107Fetal akinesia sequence (HP:0001989)2.13292739
108Nephronophthisis (HP:0000090)2.12141094
109Neuronal loss in central nervous system (HP:0002529)2.11127824
110Pheochromocytoma (HP:0002666)2.11065821
111Dysmetric saccades (HP:0000641)2.11056617
112Cerebral palsy (HP:0100021)2.10457605
113Abnormal EKG (HP:0003115)2.08388269
114Prolonged QT interval (HP:0001657)2.07907113
115Clumsiness (HP:0002312)2.06826212
116Lower limb amyotrophy (HP:0007210)2.06182793
117Polydipsia (HP:0001959)2.05256718
118Abnormal drinking behavior (HP:0030082)2.05256718
119Pancreatic fibrosis (HP:0100732)2.04705988
120Impaired vibratory sensation (HP:0002495)2.04422142
121Severe muscular hypotonia (HP:0006829)2.03945242
122Ankyloglossia (HP:0010296)2.03280502
123Abnormality of ocular smooth pursuit (HP:0000617)2.02709239
124Rapidly progressive (HP:0003678)2.01850798
125Status epilepticus (HP:0002133)2.00120186
126Polyphagia (HP:0002591)1.99984378
127Macroorchidism (HP:0000053)1.99267252
128Asymmetric septal hypertrophy (HP:0001670)1.98236297
129Joint stiffness (HP:0001387)1.98010915
130Resting tremor (HP:0002322)1.97422620
131Abnormality of renin-angiotensin system (HP:0000847)1.97139628
132Diminished motivation (HP:0000745)1.95796429
133Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.95133346
134Distal upper limb amyotrophy (HP:0007149)1.94575786
135Upper limb amyotrophy (HP:0009129)1.94575786
136Supraventricular tachycardia (HP:0004755)1.93469380
137Primary atrial arrhythmia (HP:0001692)1.91832306
138Abnormal atrioventricular conduction (HP:0005150)1.91122487
139Atrial fibrillation (HP:0005110)1.90872121
140Lower limb asymmetry (HP:0100559)1.90318491
141Annular pancreas (HP:0001734)1.89884293
142Congenital stationary night blindness (HP:0007642)1.89130234
143Atelectasis (HP:0100750)1.87649053
144Congenital sensorineural hearing impairment (HP:0008527)1.87603081
145Supraventricular arrhythmia (HP:0005115)1.85957904
146Occipital encephalocele (HP:0002085)1.85939019
147Type II lissencephaly (HP:0007260)1.82577011
148Generalized myoclonic seizures (HP:0002123)1.82109764
149Sudden death (HP:0001699)1.80796116
150Rigidity (HP:0002063)1.80008501
151Heart block (HP:0012722)1.79526041
152Hyperacusis (HP:0010780)1.79250169
153Short femoral neck (HP:0100864)1.79065684
154Large for gestational age (HP:0001520)1.77882813
155Psychosis (HP:0000709)1.77347694
156Absent speech (HP:0001344)1.76773534
157Lymphangioma (HP:0100764)1.75960428
158Abnormality of saccadic eye movements (HP:0000570)1.75473038
159Syncope (HP:0001279)1.75360807
160Alkalosis (HP:0001948)1.74671268
161Sleep apnea (HP:0010535)1.72444684
162Difficulty walking (HP:0002355)1.70837145
163Anomalous pulmonary venous return (HP:0010772)1.69643679
164Hand muscle atrophy (HP:0009130)1.67705172
165Abnormality of the renal medulla (HP:0100957)1.66442159
166Ventricular arrhythmia (HP:0004308)1.65790085
167Distal lower limb muscle weakness (HP:0009053)1.65663304
168Bronchomalacia (HP:0002780)1.65635903
169Bulbar palsy (HP:0001283)1.64765650
170Deformed sella turcica (HP:0002681)1.63327934
171Hypoplasia of the odontoid process (HP:0003311)1.62476847
172Tubular atrophy (HP:0000092)1.62165269
173Myopathic facies (HP:0002058)1.59091116

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.46575883
2EPHA44.02429133
3MAP3K93.81604359
4NTRK33.68332086
5DAPK22.67011851
6MINK12.59883424
7MAPK152.57995791
8MAP3K42.51118530
9MAP3K112.36335027
10KSR22.22457439
11PAK62.18305688
12NTRK22.17790408
13CAMKK12.15713695
14FRK2.12517795
15PRKD32.10417000
16TLK12.04592315
17MAP2K71.92876111
18TNK21.86700019
19NTRK11.74734158
20ADRBK21.70793765
21MAPKAPK31.67889378
22PHKG11.66911623
23PHKG21.66911623
24SIK21.66715743
25CDK51.58329603
26TNIK1.57704152
27MAP2K41.56819185
28KSR11.56218877
29RIPK41.54292452
30MAP2K61.54062086
31MAP3K21.50595642
32SIK11.43082124
33ERN11.34836216
34MAPK131.34792031
35PRKD21.33067770
36BLK1.32483866
37DAPK11.29462320
38INSRR1.27593490
39TESK11.26171330
40LMTK21.25004329
41TAOK11.24786455
42TYRO31.17355296
43ADRBK11.16770248
44RET1.16122778
45MAP3K121.15080590
46STK381.10882671
47LIMK11.10529731
48RIPK11.09610866
49CAMKK21.08565320
50UHMK11.05258902
51PRPF4B1.04361050
52GRK51.04114367
53MUSK1.01344187
54EPHA20.99463411
55PRKCH0.98822855
56TRIB30.98332342
57FES0.97668927
58TBK10.95450869
59PAK30.95032858
60CAMK10.94448531
61PRKCG0.92720715
62HIPK20.91838473
63LATS20.91723119
64ARAF0.91709478
65MAP3K130.90985657
66MARK20.90119314
67STK110.89043259
68EPHB20.88951709
69WNK40.87626154
70GRK10.84792498
71SGK2230.82911771
72SGK4940.82911771
73CDK190.82188628
74BCKDK0.81827858
75CAMK1G0.81034574
76PLK20.78623435
77CAMK2A0.78538345
78ABL20.77558173
79CDK150.76354852
80CDK180.75964999
81CSNK1G20.75657930
82ALK0.75572025
83PDK10.75435815
84KDR0.73710941
85CDK140.73496003
86RPS6KA60.73296243
87MAP2K20.73068899
88GRK60.72914869
89PIM20.72676776
90SGK30.72314584
91PDPK10.70199557
92RAF10.70070663
93SCYL20.69942888
94DMPK0.69497734
95OBSCN0.69442211
96ERBB30.67224582
97PKN20.66382732
98CDK11A0.66216587
99SGK20.65733949
100GRK70.65168270
101MAP2K30.65110562
102BMX0.64638869
103SGK10.64628740
104PINK10.64437513
105MAP3K10.63728529
106PNCK0.62476080
107RPS6KA20.61311072
108FYN0.61109666
109PRKCZ0.60947367
110FGFR20.60689252
111PRKD10.59952482
112PTK2B0.59774868
113EPHA30.58676316
114TIE10.57562364
115DYRK1A0.57218285
116CDC42BPA0.56655458
117MAP3K70.55863984
118ICK0.55593275
119CAMK2G0.54460977
120MYLK0.54365062
121CAMK2B0.53423198
122IKBKB0.53240731
123RPS6KL10.52506449
124RPS6KC10.52506449
125ZAP700.51053501
126PRKAA10.50571448
127CAMK40.50201935
128OXSR10.49753726
129RPS6KA30.49238650
130CASK0.48638135
131IRAK30.48570994
132MAPK70.48477034
133PRKAA20.48027842
134EPHB10.47860619
135MAP2K10.46381996
136TAOK30.46141846
137MAPK120.45344258
138PRKCE0.42676093
139PDGFRA0.42140766
140NEK60.35732085
141PKN10.35364591
142FGR0.34324949
143DYRK20.34317502
144MAPK100.33555969
145DAPK30.33391264
146ROCK10.33175343
147MAP3K60.32745272
148WNK10.32043320
149CAMK2D0.30999430

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.74193031
2Synaptic vesicle cycle_Homo sapiens_hsa047212.68932182
3Olfactory transduction_Homo sapiens_hsa047402.63694973
4Circadian entrainment_Homo sapiens_hsa047132.46957554
5GABAergic synapse_Homo sapiens_hsa047272.37581661
6Long-term potentiation_Homo sapiens_hsa047202.36583219
7Glutamatergic synapse_Homo sapiens_hsa047242.31085011
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.20815909
9Morphine addiction_Homo sapiens_hsa050322.20099550
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.15107646
11Amphetamine addiction_Homo sapiens_hsa050312.12440774
12Dopaminergic synapse_Homo sapiens_hsa047281.98078608
13Salivary secretion_Homo sapiens_hsa049701.96687378
14Gastric acid secretion_Homo sapiens_hsa049711.90731900
15Insulin secretion_Homo sapiens_hsa049111.88574953
16Cholinergic synapse_Homo sapiens_hsa047251.87786412
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.84233878
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73840517
19Renin secretion_Homo sapiens_hsa049241.64927006
20Cocaine addiction_Homo sapiens_hsa050301.59925015
21Oxytocin signaling pathway_Homo sapiens_hsa049211.56130394
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51176451
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49049661
24Sulfur relay system_Homo sapiens_hsa041221.47549689
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.46977905
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44835037
27Long-term depression_Homo sapiens_hsa047301.44338674
28Histidine metabolism_Homo sapiens_hsa003401.42805185
29Nitrogen metabolism_Homo sapiens_hsa009101.42632380
30GnRH signaling pathway_Homo sapiens_hsa049121.42179215
31Linoleic acid metabolism_Homo sapiens_hsa005911.41945734
32Taste transduction_Homo sapiens_hsa047421.39868832
33Type II diabetes mellitus_Homo sapiens_hsa049301.38271535
34Calcium signaling pathway_Homo sapiens_hsa040201.38260754
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34887909
36Gap junction_Homo sapiens_hsa045401.32804178
37Serotonergic synapse_Homo sapiens_hsa047261.30877594
38ABC transporters_Homo sapiens_hsa020101.26405729
39Glioma_Homo sapiens_hsa052141.26244983
40cAMP signaling pathway_Homo sapiens_hsa040241.25621074
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.23701392
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23428261
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22426968
44Estrogen signaling pathway_Homo sapiens_hsa049151.20886547
45Axon guidance_Homo sapiens_hsa043601.20200840
46Other glycan degradation_Homo sapiens_hsa005111.19042475
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12688968
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.11704116
49Chemical carcinogenesis_Homo sapiens_hsa052041.08698216
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07618744
51ErbB signaling pathway_Homo sapiens_hsa040121.07137774
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05049886
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02616805
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02132592
55Melanogenesis_Homo sapiens_hsa049160.99434743
56Arachidonic acid metabolism_Homo sapiens_hsa005900.97213647
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95607756
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93928248
59Lysosome_Homo sapiens_hsa041420.92565271
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.91992705
61Tryptophan metabolism_Homo sapiens_hsa003800.91735972
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.90665027
63Dorso-ventral axis formation_Homo sapiens_hsa043200.90600531
64Pancreatic secretion_Homo sapiens_hsa049720.90266967
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90178890
66Dilated cardiomyopathy_Homo sapiens_hsa054140.88058975
67Ether lipid metabolism_Homo sapiens_hsa005650.87471647
68Collecting duct acid secretion_Homo sapiens_hsa049660.85783469
69beta-Alanine metabolism_Homo sapiens_hsa004100.84063405
70PPAR signaling pathway_Homo sapiens_hsa033200.83808623
71Endometrial cancer_Homo sapiens_hsa052130.82667950
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.81784796
73VEGF signaling pathway_Homo sapiens_hsa043700.80976250
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80823313
75Glycerolipid metabolism_Homo sapiens_hsa005610.80757737
76Thyroid hormone synthesis_Homo sapiens_hsa049180.80157001
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.79714913
78Phenylalanine metabolism_Homo sapiens_hsa003600.79472743
79Cardiac muscle contraction_Homo sapiens_hsa042600.78131464
80Choline metabolism in cancer_Homo sapiens_hsa052310.78074440
81Notch signaling pathway_Homo sapiens_hsa043300.74935553
82mTOR signaling pathway_Homo sapiens_hsa041500.71551774
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71088877
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.69809875
85Bile secretion_Homo sapiens_hsa049760.68710579
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68632119
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68004302
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66305955
89Mineral absorption_Homo sapiens_hsa049780.65745843
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.65626021
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65365722
92Glucagon signaling pathway_Homo sapiens_hsa049220.64312157
93Non-small cell lung cancer_Homo sapiens_hsa052230.64091029
94MAPK signaling pathway_Homo sapiens_hsa040100.63842602
95Tyrosine metabolism_Homo sapiens_hsa003500.62479222
96Insulin signaling pathway_Homo sapiens_hsa049100.61736678
97Renal cell carcinoma_Homo sapiens_hsa052110.61444912
98Vibrio cholerae infection_Homo sapiens_hsa051100.61297749
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.60883210
100Rap1 signaling pathway_Homo sapiens_hsa040150.60212876
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59959778
102Sulfur metabolism_Homo sapiens_hsa009200.59778167
103Oocyte meiosis_Homo sapiens_hsa041140.59295325
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59062181
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58807268
106Ras signaling pathway_Homo sapiens_hsa040140.57047322
107Butanoate metabolism_Homo sapiens_hsa006500.55445156
108Endocytosis_Homo sapiens_hsa041440.55166467
109Peroxisome_Homo sapiens_hsa041460.54757808
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54106210
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51533489
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.49928127
113Arginine and proline metabolism_Homo sapiens_hsa003300.48586033
114Fructose and mannose metabolism_Homo sapiens_hsa000510.48484366
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47480287
116Phototransduction_Homo sapiens_hsa047440.47103530
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46917479
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46740784
119Inositol phosphate metabolism_Homo sapiens_hsa005620.46205241
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45527309
121Colorectal cancer_Homo sapiens_hsa052100.44993034
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44673005
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44528670
124Chemokine signaling pathway_Homo sapiens_hsa040620.44016136
125Fat digestion and absorption_Homo sapiens_hsa049750.43777525
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43160127
127Regulation of autophagy_Homo sapiens_hsa041400.42910904
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42308804
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42192563
130Prion diseases_Homo sapiens_hsa050200.41993475
131Platelet activation_Homo sapiens_hsa046110.41845066
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41804260
133Circadian rhythm_Homo sapiens_hsa047100.40654641
134Fatty acid degradation_Homo sapiens_hsa000710.40522646
135Wnt signaling pathway_Homo sapiens_hsa043100.38682964
136Prolactin signaling pathway_Homo sapiens_hsa049170.38191080
137Ovarian steroidogenesis_Homo sapiens_hsa049130.37854770
138Fatty acid biosynthesis_Homo sapiens_hsa000610.35573502
139Central carbon metabolism in cancer_Homo sapiens_hsa052300.35121709
140Insulin resistance_Homo sapiens_hsa049310.35042001
141Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34540515
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33623835

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