WDR18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.56072671
2nucleobase biosynthetic process (GO:0046112)5.36359728
3purine nucleobase biosynthetic process (GO:0009113)5.10929226
4DNA deamination (GO:0045006)5.05624556
5formation of translation preinitiation complex (GO:0001731)4.80483046
6pyrimidine nucleotide catabolic process (GO:0006244)4.69850866
7DNA strand elongation involved in DNA replication (GO:0006271)4.67234412
8pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.62826284
9maturation of SSU-rRNA (GO:0030490)4.62547781
10ribosome biogenesis (GO:0042254)4.55753804
11protein maturation by protein folding (GO:0022417)4.49523016
12DNA replication initiation (GO:0006270)4.44915520
13DNA strand elongation (GO:0022616)4.42057273
14ribosome assembly (GO:0042255)4.38331775
15proteasome assembly (GO:0043248)4.33160482
16telomere maintenance via semi-conservative replication (GO:0032201)4.29398332
17folic acid metabolic process (GO:0046655)4.20145451
18DNA unwinding involved in DNA replication (GO:0006268)4.13698209
19pyrimidine nucleoside triphosphate metabolic process (GO:0009147)4.13277049
20ribonucleoprotein complex biogenesis (GO:0022613)4.11895066
21ribosomal large subunit biogenesis (GO:0042273)4.10009892
22IMP biosynthetic process (GO:0006188)4.07465111
23folic acid-containing compound biosynthetic process (GO:0009396)4.06768701
24base-excision repair, AP site formation (GO:0006285)4.04236056
25pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)4.03086693
26DNA replication checkpoint (GO:0000076)4.02497537
27mitotic metaphase plate congression (GO:0007080)4.02082117
28ribosomal small subunit assembly (GO:0000028)3.92675996
29iron-sulfur cluster assembly (GO:0016226)3.91599656
30metallo-sulfur cluster assembly (GO:0031163)3.91599656
31spliceosomal snRNP assembly (GO:0000387)3.91528538
32L-serine metabolic process (GO:0006563)3.89552134
33deoxyribonucleotide catabolic process (GO:0009264)3.87836258
34oxidative phosphorylation (GO:0006119)3.87364898
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.81642376
36chaperone-mediated protein transport (GO:0072321)3.80069882
37rRNA modification (GO:0000154)3.78975080
38guanosine-containing compound biosynthetic process (GO:1901070)3.77547027
39anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.76029655
40rRNA processing (GO:0006364)3.74255553
41peptidyl-arginine methylation (GO:0018216)3.73891755
42peptidyl-arginine N-methylation (GO:0035246)3.73891755
43mitotic nuclear envelope disassembly (GO:0007077)3.72822138
44telomere maintenance via recombination (GO:0000722)3.71811682
45DNA replication-dependent nucleosome organization (GO:0034723)3.71771756
46DNA replication-dependent nucleosome assembly (GO:0006335)3.71771756
47deoxyribose phosphate catabolic process (GO:0046386)3.71575116
48proline biosynthetic process (GO:0006561)3.70540035
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.69884105
50regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.68470808
51pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.67318371
52UTP biosynthetic process (GO:0006228)3.67276272
53pseudouridine synthesis (GO:0001522)3.65616500
54protein localization to kinetochore (GO:0034501)3.65575467
55rRNA metabolic process (GO:0016072)3.61454133
56translational initiation (GO:0006413)3.57311627
57protein targeting to mitochondrion (GO:0006626)3.55663723
58telomere maintenance via telomere lengthening (GO:0010833)3.55262274
59IMP metabolic process (GO:0046040)3.53696119
60GDP-mannose metabolic process (GO:0019673)3.53347062
61CTP biosynthetic process (GO:0006241)3.51087643
62CTP metabolic process (GO:0046036)3.51087643
632-deoxyribonucleotide biosynthetic process (GO:0009265)3.50074534
64deoxyribose phosphate biosynthetic process (GO:0046385)3.50074534
65viral transcription (GO:0019083)3.49628143
66establishment of viral latency (GO:0019043)3.48769026
67translational termination (GO:0006415)3.48102413
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.47918167
69pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.47094134
70negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.46384692
71negative regulation of ligase activity (GO:0051352)3.46384692
72membrane disassembly (GO:0030397)3.45264543
73nuclear envelope disassembly (GO:0051081)3.45264543
74GTP biosynthetic process (GO:0006183)3.44279231
75translational elongation (GO:0006414)3.41135638
76mitotic recombination (GO:0006312)3.40249156
77UTP metabolic process (GO:0046051)3.39832099
78negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.36390182
79ribosomal small subunit biogenesis (GO:0042274)3.35692312
80positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.34054889
81CENP-A containing nucleosome assembly (GO:0034080)3.33865453
82rRNA transcription (GO:0009303)3.33601144
83transcription elongation from RNA polymerase III promoter (GO:0006385)3.33058254
84termination of RNA polymerase III transcription (GO:0006386)3.33058254
85chromatin remodeling at centromere (GO:0031055)3.31856803
86metaphase plate congression (GO:0051310)3.31825315
87base-excision repair (GO:0006284)3.31705501
88glycine metabolic process (GO:0006544)3.31368831
89nucleobase-containing small molecule interconversion (GO:0015949)3.31237642
90nuclear envelope reassembly (GO:0031468)3.31179011
91mitotic nuclear envelope reassembly (GO:0007084)3.31179011
92pentose metabolic process (GO:0019321)3.30430247
93mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.30078273
94establishment of protein localization to mitochondrion (GO:0072655)3.25386305
952-deoxyribonucleotide metabolic process (GO:0009394)3.25178735
96regulation of translational termination (GO:0006449)3.22451346
97transcription-coupled nucleotide-excision repair (GO:0006283)3.22310552
98transcription from mitochondrial promoter (GO:0006390)3.22138063
99deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.21398170
100maturation of 5.8S rRNA (GO:0000460)3.21026231
101cullin deneddylation (GO:0010388)3.20103895
102regulation of cellular amino acid metabolic process (GO:0006521)3.18433855
103cellular component biogenesis (GO:0044085)3.18338034
104deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.17115819
105nucleotide-excision repair, DNA gap filling (GO:0006297)3.16931958
106positive regulation of ligase activity (GO:0051351)3.16432554
107cell cycle G1/S phase transition (GO:0044843)3.14153867
108G1/S transition of mitotic cell cycle (GO:0000082)3.14153867
109DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.13775231
110negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.12977625
111spliceosomal complex assembly (GO:0000245)3.12495247
112regulation of spindle organization (GO:0090224)3.12305069
113regulation of translational fidelity (GO:0006450)3.11984785
114DNA replication-independent nucleosome assembly (GO:0006336)3.11000769
115DNA replication-independent nucleosome organization (GO:0034724)3.11000769
116translation (GO:0006412)3.10299700
117ATP synthesis coupled proton transport (GO:0015986)3.09982459
118energy coupled proton transport, down electrochemical gradient (GO:0015985)3.09982459
119pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.09898266
120signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.09639432
121signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.09639432
122signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.09639432
123signal transduction involved in DNA damage checkpoint (GO:0072422)3.09525045
124signal transduction involved in DNA integrity checkpoint (GO:0072401)3.09525045
125signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.09178177
126intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.09178177
127protein deneddylation (GO:0000338)3.08676005
128deoxyribose phosphate metabolic process (GO:0019692)3.08187376
129protein localization to chromosome, centromeric region (GO:0071459)3.07617132
130viral mRNA export from host cell nucleus (GO:0046784)3.06670259
131pyrimidine nucleotide biosynthetic process (GO:0006221)3.06169917
132peptidyl-arginine omega-N-methylation (GO:0035247)3.05606851
133L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.05247591
134signal transduction involved in cell cycle checkpoint (GO:0072395)3.05165930
135pyrimidine nucleotide metabolic process (GO:0006220)3.04107604
136histone arginine methylation (GO:0034969)3.02457118
137protein localization to mitochondrion (GO:0070585)3.02196893
138regulation of ubiquitin-protein transferase activity (GO:0051438)3.00496995
139nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.00344438
140regulation of mitochondrial translation (GO:0070129)2.99804934
141nucleotide salvage (GO:0043173)2.98990195
142pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.98796416
143tRNA aminoacylation for protein translation (GO:0006418)2.98225902
144establishment of integrated proviral latency (GO:0075713)2.96565248
145peptidyl-histidine modification (GO:0018202)2.95289916
146protein complex localization (GO:0031503)2.94945235
147transcription from RNA polymerase I promoter (GO:0006360)2.94840022
1487-methylguanosine mRNA capping (GO:0006370)2.94527331
149negative regulation of B cell apoptotic process (GO:0002903)2.94227798
150L-methionine salvage (GO:0071267)2.94151348
151L-methionine biosynthetic process (GO:0071265)2.94151348
152amino acid salvage (GO:0043102)2.94151348
153regulation of translation in response to stress (GO:0043555)2.93766314
154somatic hypermutation of immunoglobulin genes (GO:0016446)2.93543188
155regulation of mammary gland epithelial cell proliferation (GO:0033599)2.91677047
156deoxyribonucleotide biosynthetic process (GO:0009263)2.89716849
157tRNA methylation (GO:0030488)2.85707552
158negative regulation of mRNA processing (GO:0050686)2.84832808
159mitochondrial RNA metabolic process (GO:0000959)2.84363444

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.52663400
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.48548051
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.10631640
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.38774417
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.28340912
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.17292748
7* ETS1_20019798_ChIP-Seq_JURKAT_Human3.16774566
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.13825336
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.11924027
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.04553589
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.97038097
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.96879358
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.93202164
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.87059169
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.65942988
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.60933005
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60276701
18XRN2_22483619_ChIP-Seq_HELA_Human2.45661643
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35270843
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.23014508
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20429830
22* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18727055
23VDR_23849224_ChIP-Seq_CD4+_Human2.16680383
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.12206353
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.08579546
26DCP1A_22483619_ChIP-Seq_HELA_Human2.08110267
27* GABP_19822575_ChIP-Seq_HepG2_Human2.04935623
28FOXP3_21729870_ChIP-Seq_TREG_Human1.97122222
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.92591313
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.90644470
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.90460137
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89966658
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89652674
34* YY1_21170310_ChIP-Seq_MESCs_Mouse1.88891710
35VDR_21846776_ChIP-Seq_THP-1_Human1.88691958
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88584711
37AR_21909140_ChIP-Seq_LNCAP_Human1.84237899
38TTF2_22483619_ChIP-Seq_HELA_Human1.80188025
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76269596
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72854778
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.71249590
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65811651
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63088736
44* CIITA_25753668_ChIP-Seq_RAJI_Human1.60302216
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.59298633
46* TET1_21451524_ChIP-Seq_MESCs_Mouse1.56942830
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.55516369
48* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54127494
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.53642084
50KDM5A_27292631_Chip-Seq_BREAST_Human1.49119712
51LXR_22292898_ChIP-Seq_THP-1_Human1.47960132
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47397701
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44959879
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44226717
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44194079
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39860408
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38945127
58MYC_22102868_ChIP-Seq_BL_Human1.38096653
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36543635
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35353698
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34815519
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31489480
63* P68_20966046_ChIP-Seq_HELA_Human1.29087581
64* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.28580693
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27031671
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25744290
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25714029
68FOXP1_21924763_ChIP-Seq_HESCs_Human1.23962700
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.22824955
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.22714746
71ELK1_19687146_ChIP-ChIP_HELA_Human1.19350780
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18608824
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17902247
74* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16693588
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15736696
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14896524
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14272213
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12373413
79ZNF263_19887448_ChIP-Seq_K562_Human1.11518815
80* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11029680
81SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10390352
82* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07974243
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07900006
84* BCL6_27268052_Chip-Seq_Bcells_Human1.06455640
85TFEB_21752829_ChIP-Seq_HELA_Human1.06100723
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05533650
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05362439
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03555715
89OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02824124
90* CTCF_26484167_Chip-Seq_Bcells_Mouse1.02729554
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02715883
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02455136
93* SA1_27219007_Chip-Seq_ERYTHROID_Human1.01832790
94NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00575715
95RACK7_27058665_Chip-Seq_MCF-7_Human1.00537822
96* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00296826
97EGR1_19374776_ChIP-ChIP_THP-1_Human1.00246023
98PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00079266
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00013419
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99322734
101CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99014748
102TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98628226
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98106941
104NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97840111
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96539164
106NOTCH1_21737748_ChIP-Seq_TLL_Human0.96073316
107SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95424822
108* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95005715
109BP1_19119308_ChIP-ChIP_Hs578T_Human0.94995156
110TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94440174
111SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93169228
112* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92771109
113* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91513056
114ELK1_22589737_ChIP-Seq_MCF10A_Human0.91454099
115* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91047445
116ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90529146
117* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90190351
118CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89189522
119NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88456631
120MYC_18940864_ChIP-ChIP_HL60_Human0.88204248
121ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88100038
122NANOG_21062744_ChIP-ChIP_HESCs_Human0.87592373

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.21577400
2MP0004957_abnormal_blastocyst_morpholog5.04383325
3MP0003111_abnormal_nucleus_morphology4.95670137
4MP0010094_abnormal_chromosome_stability4.41421563
5MP0003077_abnormal_cell_cycle4.05120996
6MP0003806_abnormal_nucleotide_metabolis3.52648019
7MP0008058_abnormal_DNA_repair3.44027864
8MP0008057_abnormal_DNA_replication3.15902292
9MP0005451_abnormal_body_composition2.96294034
10MP0008932_abnormal_embryonic_tissue2.90544558
11MP0003123_paternal_imprinting2.77464241
12MP0001730_embryonic_growth_arrest2.73694292
13MP0008007_abnormal_cellular_replicative2.70798677
14MP0003718_maternal_effect2.38486186
15MP0000350_abnormal_cell_proliferation2.24248157
16MP0000678_abnormal_parathyroid_gland2.18207573
17MP0002396_abnormal_hematopoietic_system2.07850940
18MP0010352_gastrointestinal_tract_polyps2.04683900
19MP0003786_premature_aging2.03747245
20MP0008877_abnormal_DNA_methylation2.01651035
21MP0001672_abnormal_embryogenesis/_devel1.90611391
22MP0005380_embryogenesis_phenotype1.90611391
23MP0001697_abnormal_embryo_size1.87990046
24MP0002080_prenatal_lethality1.85185443
25MP0009278_abnormal_bone_marrow1.83710219
26MP0002234_abnormal_pharynx_morphology1.78455649
27MP0005501_abnormal_skin_physiology1.76252198
28MP0003984_embryonic_growth_retardation1.71419015
29MP0004858_abnormal_nervous_system1.70142510
30MP0002088_abnormal_embryonic_growth/wei1.68327092
31MP0005058_abnormal_lysosome_morphology1.66072285
32MP0006036_abnormal_mitochondrial_physio1.62211371
33MP0002163_abnormal_gland_morphology1.59482215
34MP0003186_abnormal_redox_activity1.54665731
35MP0004133_heterotaxia1.53957890
36MP0002085_abnormal_embryonic_tissue1.53904583
37MP0006035_abnormal_mitochondrial_morpho1.52960260
38MP0010307_abnormal_tumor_latency1.51113254
39MP0009840_abnormal_foam_cell1.48760326
40MP0000358_abnormal_cell_content/1.47738265
41MP0000049_abnormal_middle_ear1.46087894
42MP0000313_abnormal_cell_death1.44289277
43MP0002877_abnormal_melanocyte_morpholog1.40322546
44MP0002249_abnormal_larynx_morphology1.39590284
45MP0010030_abnormal_orbit_morphology1.36735438
46MP0002084_abnormal_developmental_patter1.36364850
47MP0002086_abnormal_extraembryonic_tissu1.35961308
48MP0003567_abnormal_fetal_cardiomyocyte1.35546120
49MP0002019_abnormal_tumor_incidence1.32873790
50MP0003315_abnormal_perineum_morphology1.31800519
51MP0006292_abnormal_olfactory_placode1.30830919
52MP0001849_ear_inflammation1.29037119
53MP0009672_abnormal_birth_weight1.27184971
54MP0004197_abnormal_fetal_growth/weight/1.26582044
55MP0000490_abnormal_crypts_of1.25229717
56MP0001661_extended_life_span1.22208590
57MP0002160_abnormal_reproductive_system1.21152339
58MP0005394_taste/olfaction_phenotype1.20177194
59MP0005499_abnormal_olfactory_system1.20177194
60MP0008789_abnormal_olfactory_epithelium1.19603177
61MP0005623_abnormal_meninges_morphology1.18717343
62MP0003119_abnormal_digestive_system1.18671970
63MP0002210_abnormal_sex_determination1.14986566
64MP0001764_abnormal_homeostasis1.14036942
65MP0003221_abnormal_cardiomyocyte_apopto1.13852612
66MP0004185_abnormal_adipocyte_glucose1.13176830
67MP0002269_muscular_atrophy1.10109735
68MP0001145_abnormal_male_reproductive1.09894320
69MP0000750_abnormal_muscle_regeneration1.08226622
70MP0002653_abnormal_ependyma_morphology1.06810837
71MP0009333_abnormal_splenocyte_physiolog1.06621197
72MP0001727_abnormal_embryo_implantation1.06011099
73MP0009053_abnormal_anal_canal1.04909624
74MP0000681_abnormal_thyroid_gland1.03263648
75MP0005266_abnormal_metabolism0.99912779
76MP0009697_abnormal_copulation0.98050781
77MP0001293_anophthalmia0.97685680
78MP0000537_abnormal_urethra_morphology0.95584552
79MP0001346_abnormal_lacrimal_gland0.93160168
80MP0002796_impaired_skin_barrier0.92749472
81MP0002132_abnormal_respiratory_system0.92193353
82MP0005389_reproductive_system_phenotype0.91213727
83MP0003890_abnormal_embryonic-extraembry0.90882961
84MP0004808_abnormal_hematopoietic_stem0.90183918
85MP0001929_abnormal_gametogenesis0.90024686
86MP0000653_abnormal_sex_gland0.89841386
87MP0003646_muscle_fatigue0.89118328
88MP0002111_abnormal_tail_morphology0.88069432
89MP0001873_stomach_inflammation0.86015575
90MP0005332_abnormal_amino_acid0.85709865
91MP0005384_cellular_phenotype0.85486385
92MP0003705_abnormal_hypodermis_morpholog0.82303816
93MP0005397_hematopoietic_system_phenotyp0.82204661
94MP0001545_abnormal_hematopoietic_system0.82204661
95MP0004233_abnormal_muscle_weight0.81560761
96MP0001529_abnormal_vocalization0.80607271
97MP0001881_abnormal_mammary_gland0.80504268
98MP0005085_abnormal_gallbladder_physiolo0.79524560
99MP0000598_abnormal_liver_morphology0.78175513
100MP0002139_abnormal_hepatobiliary_system0.77483854
101MP0003941_abnormal_skin_development0.77134556
102MP0000467_abnormal_esophagus_morphology0.76699251
103MP0009379_abnormal_foot_pigmentation0.74535921
104MP0000703_abnormal_thymus_morphology0.74202570
105MP0009703_decreased_birth_body0.73289579
106MP0005319_abnormal_enzyme/_coenzyme0.73013410
107MP0005395_other_phenotype0.72265436
108MP0008260_abnormal_autophagy0.71305839
109MP0005621_abnormal_cell_physiology0.70357966
110MP0003656_abnormal_erythrocyte_physiolo0.70283603
111MP0001119_abnormal_female_reproductive0.69057804
112MP0004084_abnormal_cardiac_muscle0.68792619
113MP0002722_abnormal_immune_system0.68331138
114MP0005023_abnormal_wound_healing0.67835447
115MP0005360_urolithiasis0.67780750
116MP0003121_genomic_imprinting0.67046888
117MP0000003_abnormal_adipose_tissue0.66469163
118MP0000858_altered_metastatic_potential0.65771930
119MP0001919_abnormal_reproductive_system0.65419596
120MP0000689_abnormal_spleen_morphology0.63682847
121MP0000751_myopathy0.62903567
122MP0005083_abnormal_biliary_tract0.62420513
123MP0002429_abnormal_blood_cell0.61718299
124MP0000747_muscle_weakness0.61423520
125MP0005666_abnormal_adipose_tissue0.60289528
126MP0004147_increased_porphyrin_level0.60273092
127MP0001853_heart_inflammation0.59243872
128MP0005330_cardiomyopathy0.58877031
129MP0003385_abnormal_body_wall0.58796739
130MP0000759_abnormal_skeletal_muscle0.54206312
131MP0008770_decreased_survivor_rate0.53741993
132MP0002398_abnormal_bone_marrow0.53089024
133MP0000477_abnormal_intestine_morphology0.52400207
134MP0005670_abnormal_white_adipose0.51892674
135MP0002161_abnormal_fertility/fecundity0.51195287
136MP0005376_homeostasis/metabolism_phenot0.50923271

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.13461522
2Breast hypoplasia (HP:0003187)4.52673080
3Oral leukoplakia (HP:0002745)4.35460591
4Cerebral hypomyelination (HP:0006808)4.20608588
5Abnormal mitochondria in muscle tissue (HP:0008316)3.97060514
6Carpal bone hypoplasia (HP:0001498)3.90183114
7Ragged-red muscle fibers (HP:0003200)3.83093478
8Abnormality of the anterior horn cell (HP:0006802)3.72100909
9Degeneration of anterior horn cells (HP:0002398)3.72100909
10Abnormality of cells of the erythroid lineage (HP:0012130)3.69787653
11Reticulocytopenia (HP:0001896)3.59603960
12Acute necrotizing encephalopathy (HP:0006965)3.56991867
13Mitochondrial inheritance (HP:0001427)3.55677234
14Rough bone trabeculation (HP:0100670)3.55356978
15Abnormal number of erythroid precursors (HP:0012131)3.54210066
16Acute encephalopathy (HP:0006846)3.47105528
17Multiple enchondromatosis (HP:0005701)3.43282165
18Colon cancer (HP:0003003)3.36471169
19Selective tooth agenesis (HP:0001592)3.35667190
20Patellar aplasia (HP:0006443)3.25406467
21Broad distal phalanx of finger (HP:0009836)3.17156218
22Aplasia/Hypoplasia of the patella (HP:0006498)3.12500140
23Increased intramyocellular lipid droplets (HP:0012240)3.10525236
24Abnormality of pyrimidine metabolism (HP:0004353)3.08927836
25Trismus (HP:0000211)3.08905746
26Type I transferrin isoform profile (HP:0003642)3.06344951
27Macrocytic anemia (HP:0001972)3.01234901
28Microretrognathia (HP:0000308)3.00239453
29Premature ovarian failure (HP:0008209)2.98196089
30Exercise intolerance (HP:0003546)2.96543374
31Increased muscle lipid content (HP:0009058)2.96014674
32Testicular atrophy (HP:0000029)2.88264255
33Progressive muscle weakness (HP:0003323)2.87482149
34Ependymoma (HP:0002888)2.87423394
35Abnormal gallbladder physiology (HP:0012438)2.85979720
36Cholecystitis (HP:0001082)2.85979720
37Hyperglycinemia (HP:0002154)2.85212498
38Secondary amenorrhea (HP:0000869)2.78724648
39Absent thumb (HP:0009777)2.74824301
40Aplastic anemia (HP:0001915)2.72826108
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.70515152
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.70515152
43Increased serum lactate (HP:0002151)2.69169420
44Truncus arteriosus (HP:0001660)2.66729281
45Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.65964735
46Megaloblastic anemia (HP:0001889)2.64750093
47Cerebral edema (HP:0002181)2.61219636
48Neoplasm of the pancreas (HP:0002894)2.59768248
49Abnormal glycosylation (HP:0012345)2.56462804
50Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.56462804
51Abnormal protein N-linked glycosylation (HP:0012347)2.56462804
52Abnormal protein glycosylation (HP:0012346)2.56462804
53Absent radius (HP:0003974)2.56052586
54Horseshoe kidney (HP:0000085)2.55299911
55Impulsivity (HP:0100710)2.51330010
56Abnormal trabecular bone morphology (HP:0100671)2.50088747
57Atrophy/Degeneration involving motor neurons (HP:0007373)2.49011869
58Abnormality of the labia minora (HP:0012880)2.48815029
59Progressive macrocephaly (HP:0004481)2.45850372
60Abnormality of glycolysis (HP:0004366)2.44646732
61Increased serum pyruvate (HP:0003542)2.44646732
62CNS hypomyelination (HP:0003429)2.39974505
63Reduced antithrombin III activity (HP:0001976)2.39683101
64Cellular immunodeficiency (HP:0005374)2.39427076
65Hyperglycinuria (HP:0003108)2.38620148
66Meckel diverticulum (HP:0002245)2.37412805
67Hypertensive crisis (HP:0100735)2.37121144
68Premature graying of hair (HP:0002216)2.35681228
69Medulloblastoma (HP:0002885)2.35301625
70Aplasia involving forearm bones (HP:0009822)2.34848190
71Absent forearm bone (HP:0003953)2.34848190
72Rhabdomyosarcoma (HP:0002859)2.33783784
73Opisthotonus (HP:0002179)2.33564824
74CNS demyelination (HP:0007305)2.28044835
75Hepatocellular necrosis (HP:0001404)2.25923506
76Pallor (HP:0000980)2.25801616
77Hepatic necrosis (HP:0002605)2.25059829
78Abnormality of the preputium (HP:0100587)2.24880969
79Respiratory failure (HP:0002878)2.24130504
80Agnosia (HP:0010524)2.22940906
81Aplasia/Hypoplasia of the sacrum (HP:0008517)2.22634570
82Abnormality of the ileum (HP:0001549)2.21467004
83Squamous cell carcinoma (HP:0002860)2.19954850
84Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17740596
85Dicarboxylic aciduria (HP:0003215)2.17740596
86Emotional lability (HP:0000712)2.17309411
87Hypobetalipoproteinemia (HP:0003563)2.15317805
88Pancytopenia (HP:0001876)2.15095257
89Lipid accumulation in hepatocytes (HP:0006561)2.14215840
90Increased hepatocellular lipid droplets (HP:0006565)2.13576657
91Cleft eyelid (HP:0000625)2.13221837
92Sparse eyelashes (HP:0000653)2.13125046
93Abnormality of serum amino acid levels (HP:0003112)2.12819113
94Microvesicular hepatic steatosis (HP:0001414)2.11864070
95Unsteady gait (HP:0002317)2.11772294
96Nausea (HP:0002018)2.10825403
97Renal Fanconi syndrome (HP:0001994)2.09662075
98Postnatal microcephaly (HP:0005484)2.09003407
99Progressive microcephaly (HP:0000253)2.08480330
100Increased CSF lactate (HP:0002490)2.07770378
101Bone marrow hypocellularity (HP:0005528)2.07458347
102Personality changes (HP:0000751)2.06804428
103Abnormality of glycine metabolism (HP:0010895)2.06363396
104Abnormality of serine family amino acid metabolism (HP:0010894)2.06363396
105Hyperthyroidism (HP:0000836)2.05468004
106Double outlet right ventricle (HP:0001719)2.05371665
107Congenital malformation of the right heart (HP:0011723)2.05371665
108Angiofibromas (HP:0010615)2.02455690
109Adenoma sebaceum (HP:0009720)2.02455690
110Abnormality of alanine metabolism (HP:0010916)2.02043564
111Hyperalaninemia (HP:0003348)2.02043564
112Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02043564
113Slender long bone (HP:0003100)2.01128824
114Basal cell carcinoma (HP:0002671)1.99465648
115Hypergonadotropic hypogonadism (HP:0000815)1.99257621
116Respiratory difficulties (HP:0002880)1.98173411
117Cerebral palsy (HP:0100021)1.97532149
118Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97498630
119Abnormality of the motor neurons (HP:0002450)1.96250186
120Abnormal neuron morphology (HP:0012757)1.96250186
121Abnormality of the umbilical cord (HP:0010881)1.96198586
12211 pairs of ribs (HP:0000878)1.95187666
123Delayed CNS myelination (HP:0002188)1.95164898
124Aplasia/Hypoplasia of the uvula (HP:0010293)1.94932986
125Abnormality of monocarboxylic acid metabolism (HP:0010996)1.94733220
126Death in infancy (HP:0001522)1.94563081
127Lactic acidosis (HP:0003128)1.93490098
128Abnormality of chromosome stability (HP:0003220)1.92692401
129Chromsome breakage (HP:0040012)1.91879110
130Hypokinesia (HP:0002375)1.91484900
131Abnormality of reticulocytes (HP:0004312)1.90072891
132Supernumerary spleens (HP:0009799)1.89783908
133Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88776434
134Lethargy (HP:0001254)1.88750872
135Delusions (HP:0000746)1.88705267
136Spastic diplegia (HP:0001264)1.87982285
137Atresia of the external auditory canal (HP:0000413)1.86534745
138Chromosomal breakage induced by crosslinking agents (HP:0003221)1.85211909
139Myopathic facies (HP:0002058)1.84400322
140Abnormal number of incisors (HP:0011064)1.84319707
141Cholelithiasis (HP:0001081)1.83870026
142Glossoptosis (HP:0000162)1.83760760
143Abnormality of the fetal cardiovascular system (HP:0010948)1.83156179
144Abnormal umbilical cord blood vessels (HP:0011403)1.83156179
145Single umbilical artery (HP:0001195)1.83156179
146Optic nerve coloboma (HP:0000588)1.81242195
147Redundant skin (HP:0001582)1.79396120
148Gliosis (HP:0002171)1.79148801
149Seborrheic dermatitis (HP:0001051)1.78054709
150Hepatosplenomegaly (HP:0001433)1.76375134
151Achilles tendon contracture (HP:0001771)1.75555337
152Hyperacusis (HP:0010780)1.75109100
153Transposition of the great arteries (HP:0001669)1.74096146
154Abnormal connection of the cardiac segments (HP:0011545)1.74096146
155Abnormal ventriculo-arterial connection (HP:0011563)1.74096146
156Hypoplasia of the capital femoral epiphysis (HP:0003090)1.68343312
157Muscle fiber atrophy (HP:0100295)1.64990664
158Hypoplastic left heart (HP:0004383)1.64465271

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.86738570
2VRK25.52318953
3WEE14.08327094
4EIF2AK13.80274797
5SMG13.72861826
6CDC72.96578643
7NEK12.93875881
8TSSK62.92817838
9TESK22.63482235
10NME22.42829405
11STK162.36045124
12SRPK12.29259461
13NEK22.27254910
14TTK2.23737447
15BCKDK2.20096670
16EPHA22.15045233
17PLK42.09057236
18EIF2AK32.04677668
19PLK11.94610878
20TAF11.93147878
21TLK11.80428653
22BRSK21.71931242
23CSNK1G31.52682860
24BRSK11.50897262
25AURKA1.48353656
26CDK71.46396597
27AURKB1.44935688
28PLK31.42449000
29ACVR1B1.40774213
30MAP3K111.39378642
31VRK11.36560097
32PBK1.36327967
33DYRK31.34531738
34SCYL21.32393034
35MAP3K81.31567773
36RPS6KB21.31103435
37ATR1.28643437
38PRKD31.27801441
39CSNK1A1L1.26893671
40RPS6KA41.26526519
41PDK31.25120166
42PDK41.25120166
43KDR1.23728458
44PIM21.22870871
45EEF2K1.19410204
46TESK11.17568401
47PAK41.15829524
48PASK1.15088718
49BRAF1.12599392
50ZAK1.12439955
51CHEK21.10993446
52CCNB11.10147130
53CDK41.07214576
54NME11.05610962
55MKNK11.03915148
56CDK191.03197793
57CSNK1G11.02043987
58CHEK10.96410334
59PKN20.94596389
60ICK0.94350178
61PRKCI0.93297744
62ERN10.91541983
63CSNK1G20.91263092
64MAPKAPK30.88142251
65MAP3K100.87002234
66MKNK20.85397274
67ALK0.80993021
68PAK10.80153998
69LATS20.79830801
70CDK80.79478410
71NUAK10.76671476
72CSNK2A20.76065638
73MAP2K30.73220632
74CDK20.72970724
75PNCK0.72945022
76STK38L0.71034493
77STK40.69630671
78AKT30.68248411
79CSNK2A10.67835306
80STK100.66235902
81FLT30.65439965
82ARAF0.63743317
83DAPK10.60714191
84MAPK110.59844309
85PIM10.59175596
86CDK11A0.58930555
87CDK140.58903750
88CDK90.56875780
89ATM0.52793992
90PDK20.52325572
91CDK150.51774199
92IRAK30.51485873
93TAOK20.50843474
94CDK120.50048128
95ILK0.49815906
96CDK180.48560662
97TGFBR10.47731562
98MAP2K70.47224010
99CSNK1E0.46939978
100TBK10.46874449
101ABL20.46785021
102CDK10.46355497
103EIF2AK20.45299887
104LRRK20.44624849
105DAPK30.44301512
106MAP4K10.44054767
107AKT20.43339162
108MOS0.42921534
109MAPKAPK50.39217185
110TRIB30.38829278
111MTOR0.36456308
112MAP3K30.35069709
113DYRK20.34348790
114MAP4K20.33828384
115MAP2K20.33718791
116LIMK10.33242900
117PRPF4B0.31875938
118GRK50.31393205
119MAP3K50.31167433
120NEK90.29858485
121RAF10.29609007
122CAMK2G0.29147856
123GRK60.26001018
124TAOK10.25749563
125RPS6KA50.25057545
126BMX0.24476707
127ZAP700.23605110
128PRKDC0.20836841
129FGFR10.19987017

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.51334765
2Proteasome_Homo sapiens_hsa030504.02931431
3Mismatch repair_Homo sapiens_hsa034303.83851372
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.78635825
5RNA polymerase_Homo sapiens_hsa030203.46978953
6Ribosome_Homo sapiens_hsa030103.43480167
7RNA transport_Homo sapiens_hsa030133.05166154
8Spliceosome_Homo sapiens_hsa030403.01459640
9One carbon pool by folate_Homo sapiens_hsa006702.82018728
10Base excision repair_Homo sapiens_hsa034102.69329815
11Pyrimidine metabolism_Homo sapiens_hsa002402.63943962
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.62995717
13Nucleotide excision repair_Homo sapiens_hsa034202.48561885
14Homologous recombination_Homo sapiens_hsa034402.39753572
15Cell cycle_Homo sapiens_hsa041102.05674215
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.86098181
17Biosynthesis of amino acids_Homo sapiens_hsa012301.72260387
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.69930268
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.65415981
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61296461
21Fatty acid elongation_Homo sapiens_hsa000621.56796792
22Vitamin B6 metabolism_Homo sapiens_hsa007501.54324415
23Fanconi anemia pathway_Homo sapiens_hsa034601.52646580
24RNA degradation_Homo sapiens_hsa030181.49711353
25Sulfur relay system_Homo sapiens_hsa041221.46569945
26Folate biosynthesis_Homo sapiens_hsa007901.45764196
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.43503776
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43291197
29Basal transcription factors_Homo sapiens_hsa030221.42945868
30Carbon metabolism_Homo sapiens_hsa012001.42076751
31Non-homologous end-joining_Homo sapiens_hsa034501.41082015
32Purine metabolism_Homo sapiens_hsa002301.38465329
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.37609408
34mRNA surveillance pathway_Homo sapiens_hsa030151.32103906
35Pentose phosphate pathway_Homo sapiens_hsa000301.30146443
36Selenocompound metabolism_Homo sapiens_hsa004501.24175901
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10727593
38p53 signaling pathway_Homo sapiens_hsa041151.10217426
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07132359
40Epstein-Barr virus infection_Homo sapiens_hsa051690.97428982
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95763586
42Parkinsons disease_Homo sapiens_hsa050120.94202812
43Fructose and mannose metabolism_Homo sapiens_hsa000510.92836487
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92028547
45Huntingtons disease_Homo sapiens_hsa050160.88715014
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88198573
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86506717
48Pyruvate metabolism_Homo sapiens_hsa006200.81463706
49Oocyte meiosis_Homo sapiens_hsa041140.79730698
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77837958
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77586126
52Glutathione metabolism_Homo sapiens_hsa004800.77431537
53Oxidative phosphorylation_Homo sapiens_hsa001900.74423480
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72957166
55Sulfur metabolism_Homo sapiens_hsa009200.72850806
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71810597
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69255382
58Systemic lupus erythematosus_Homo sapiens_hsa053220.65999411
59Steroid biosynthesis_Homo sapiens_hsa001000.65169656
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60453500
61Galactose metabolism_Homo sapiens_hsa000520.57523292
62Vibrio cholerae infection_Homo sapiens_hsa051100.55249433
63Fatty acid metabolism_Homo sapiens_hsa012120.55038057
64Arginine biosynthesis_Homo sapiens_hsa002200.52345266
65Metabolic pathways_Homo sapiens_hsa011000.51769161
66Arginine and proline metabolism_Homo sapiens_hsa003300.49134231
67Antigen processing and presentation_Homo sapiens_hsa046120.47524582
68Thyroid cancer_Homo sapiens_hsa052160.46490839
69Primary immunodeficiency_Homo sapiens_hsa053400.45101156
70Viral carcinogenesis_Homo sapiens_hsa052030.44959935
71Propanoate metabolism_Homo sapiens_hsa006400.43295952
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42774043
73Shigellosis_Homo sapiens_hsa051310.41462869
74Protein export_Homo sapiens_hsa030600.38396339
75Regulation of autophagy_Homo sapiens_hsa041400.35204455
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34610404
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33503922
78HTLV-I infection_Homo sapiens_hsa051660.33429760
79Herpes simplex infection_Homo sapiens_hsa051680.31331123
80Cardiac muscle contraction_Homo sapiens_hsa042600.31185962
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29584411
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28003866
83Fatty acid degradation_Homo sapiens_hsa000710.27768623
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26980580
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.26107651
86Other glycan degradation_Homo sapiens_hsa005110.25708600
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.25429112
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.23603911
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22833893
90N-Glycan biosynthesis_Homo sapiens_hsa005100.22588213
91Notch signaling pathway_Homo sapiens_hsa043300.22499147
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22001717
93Phenylalanine metabolism_Homo sapiens_hsa003600.21762755
94beta-Alanine metabolism_Homo sapiens_hsa004100.21602771
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.20532081
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20268378
97Legionellosis_Homo sapiens_hsa051340.20117696
98Bladder cancer_Homo sapiens_hsa052190.19914754
99Peroxisome_Homo sapiens_hsa041460.19894357
100Alzheimers disease_Homo sapiens_hsa050100.19810071
101Fat digestion and absorption_Homo sapiens_hsa049750.19077975
102Basal cell carcinoma_Homo sapiens_hsa052170.18226163
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.17874134
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.17417844
105HIF-1 signaling pathway_Homo sapiens_hsa040660.17315836
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16758119
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15459418
108Vitamin digestion and absorption_Homo sapiens_hsa049770.12561627
109Acute myeloid leukemia_Homo sapiens_hsa052210.09962517
110Hippo signaling pathway_Homo sapiens_hsa043900.09205496
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.08785371
112Tyrosine metabolism_Homo sapiens_hsa003500.08563045
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.07630101
114Butanoate metabolism_Homo sapiens_hsa006500.06877999
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.05672057
116Tryptophan metabolism_Homo sapiens_hsa003800.04390581
117Apoptosis_Homo sapiens_hsa042100.03175656
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.02774793
119Alcoholism_Homo sapiens_hsa050340.02432366
120Renin-angiotensin system_Homo sapiens_hsa046140.02404683

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