WDR20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)7.38097317
2regulation of female gonad development (GO:2000194)5.82018714
3piRNA metabolic process (GO:0034587)5.77134107
4mitotic metaphase plate congression (GO:0007080)5.35399206
5female gamete generation (GO:0007292)5.34363668
6regulation of histone H3-K27 methylation (GO:0061085)5.32725061
7regulation of RIG-I signaling pathway (GO:0039535)5.19139015
8plasma membrane fusion (GO:0045026)5.07787406
9mitotic chromosome condensation (GO:0007076)5.03841192
10protein K11-linked deubiquitination (GO:0035871)5.02116581
11meiotic cell cycle (GO:0051321)4.95572084
12regulation of meiosis (GO:0040020)4.91481523
13RNA destabilization (GO:0050779)4.85406243
14glycerophospholipid catabolic process (GO:0046475)4.83673968
15regulation of exit from mitosis (GO:0007096)4.82951463
16negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.79512873
17negative regulation of DNA-templated transcription, elongation (GO:0032785)4.79512873
18negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.72473187
19attachment of spindle microtubules to kinetochore (GO:0008608)4.62235629
20negative regulation of NF-kappaB import into nucleus (GO:0042347)4.51429619
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.43094040
22establishment of protein localization to Golgi (GO:0072600)4.37622459
23male meiosis (GO:0007140)4.28536974
24metaphase plate congression (GO:0051310)4.28493737
25single strand break repair (GO:0000012)4.26315937
26regulation of meiosis I (GO:0060631)4.24240308
27oocyte maturation (GO:0001556)4.19640108
28regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.17030001
29DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.10437377
30DNA damage response, signal transduction resulting in transcription (GO:0042772)4.09069546
31sperm motility (GO:0030317)4.02657955
32acrosome reaction (GO:0007340)4.01655371
33regulation of meiotic cell cycle (GO:0051445)3.99993939
34retrograde transport, vesicle recycling within Golgi (GO:0000301)3.95483134
35histone H2A monoubiquitination (GO:0035518)3.95479335
36maturation of 5.8S rRNA (GO:0000460)3.93532025
37negative regulation of meiosis (GO:0045835)3.88814710
38peptidyl-threonine dephosphorylation (GO:0035970)3.79013148
39protein polyglutamylation (GO:0018095)3.78755228
40DNA methylation involved in gamete generation (GO:0043046)3.78290888
41regulation of DNA methylation (GO:0044030)3.73499939
42establishment of chromosome localization (GO:0051303)3.70841257
43snRNA transcription (GO:0009301)3.69709664
44interleukin-6-mediated signaling pathway (GO:0070102)3.66280116
45negative regulation of inclusion body assembly (GO:0090084)3.63470518
46negative regulation of meiotic cell cycle (GO:0051447)3.58213247
47negative regulation of cAMP-mediated signaling (GO:0043951)3.57709249
48DNA damage induced protein phosphorylation (GO:0006975)3.57268894
49regulation of sister chromatid cohesion (GO:0007063)3.55197304
50regulation of retinoic acid receptor signaling pathway (GO:0048385)3.54274759
51inositol phosphate catabolic process (GO:0071545)3.53391723
52protein localization to kinetochore (GO:0034501)3.53055209
53positive regulation of mitochondrial fission (GO:0090141)3.49163553
54early endosome to late endosome transport (GO:0045022)3.48001094
55positive regulation of chromosome segregation (GO:0051984)3.45807536
56positive regulation of granulocyte differentiation (GO:0030854)3.43538786
57protein localization to chromosome, centromeric region (GO:0071459)3.42054451
58protein K6-linked ubiquitination (GO:0085020)3.30612451
59histone H2A ubiquitination (GO:0033522)3.29552996
60oocyte development (GO:0048599)3.28508502
61histone H3-K4 methylation (GO:0051568)3.26455742
62female gonad development (GO:0008585)3.25590541
63neural tube formation (GO:0001841)3.21381724
64pyrimidine-containing compound transmembrane transport (GO:0072531)3.20315102
65protein localization to chromosome (GO:0034502)3.19003512
66meiotic chromosome segregation (GO:0045132)3.17030978
67monoubiquitinated protein deubiquitination (GO:0035520)3.16153978
68positive regulation of receptor recycling (GO:0001921)3.15515281
69protein localization to Golgi apparatus (GO:0034067)3.14654675
70mitotic sister chromatid segregation (GO:0000070)3.14547919
71neurofilament cytoskeleton organization (GO:0060052)3.14486608
72keratinocyte development (GO:0003334)3.11287002
73intraciliary transport (GO:0042073)3.10360286
74histone H3-K4 trimethylation (GO:0080182)3.09771675
75chromatin remodeling at centromere (GO:0031055)3.08382122
76CENP-A containing nucleosome assembly (GO:0034080)3.08160025
77fusion of sperm to egg plasma membrane (GO:0007342)3.08095701
78sperm-egg recognition (GO:0035036)3.07369769
79binding of sperm to zona pellucida (GO:0007339)3.06023093
80phosphorylated carbohydrate dephosphorylation (GO:0046838)3.03930727
81inositol phosphate dephosphorylation (GO:0046855)3.03930727
82positive regulation of macroautophagy (GO:0016239)3.03571415
83proteasome assembly (GO:0043248)3.00426400
84protein K48-linked ubiquitination (GO:0070936)2.99595110
85regulation of mitochondrial fission (GO:0090140)2.99584996
86negative regulation of alcohol biosynthetic process (GO:1902931)2.98797072
87regulation of spindle organization (GO:0090224)2.98330632
88spermatid development (GO:0007286)2.97096025
89negative regulation of hormone biosynthetic process (GO:0032353)2.96665664
90negative regulation of hormone metabolic process (GO:0032351)2.96665664
91sister chromatid cohesion (GO:0007062)2.92540635
92response to muramyl dipeptide (GO:0032495)2.92283628
93negative regulation of DNA recombination (GO:0045910)2.91931071
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.86910287
95regulation of mitotic spindle organization (GO:0060236)2.86309873
96microtubule depolymerization (GO:0007019)2.85899398
97base-excision repair, AP site formation (GO:0006285)2.85743152
98response to redox state (GO:0051775)2.85691182
99mitochondrial calcium ion transport (GO:0006851)2.84868800
100histone mRNA catabolic process (GO:0071044)2.84631266
101male meiosis I (GO:0007141)2.82467957
102multicellular organism reproduction (GO:0032504)2.81611577
103spindle checkpoint (GO:0031577)2.81358205
104intra-Golgi vesicle-mediated transport (GO:0006891)2.80025797
105chromosome segregation (GO:0007059)2.76783574
106microtubule severing (GO:0051013)2.76248470
107establishment of spindle orientation (GO:0051294)2.76113024
108establishment of spindle localization (GO:0051293)2.75665698
109epithelial cilium movement (GO:0003351)2.75541682
110Golgi to endosome transport (GO:0006895)2.75134782
111centriole replication (GO:0007099)2.74944311
112regulation of acrosome reaction (GO:0060046)2.74582434
113spermatogenesis (GO:0007283)2.71797841
114reproduction (GO:0000003)2.71550941
115positive regulation of megakaryocyte differentiation (GO:0045654)2.71513923
116male gamete generation (GO:0048232)2.70432692
117peptidyl-lysine trimethylation (GO:0018023)2.70073662
118negative regulation of mast cell activation (GO:0033004)2.70064257
119regulation of chromosome segregation (GO:0051983)2.68677862
120cilium organization (GO:0044782)2.68661637
121meiotic nuclear division (GO:0007126)2.68497333
122DNA alkylation (GO:0006305)2.68227026
123DNA methylation (GO:0006306)2.68227026
124DNA replication-independent nucleosome organization (GO:0034724)2.67466868
125DNA replication-independent nucleosome assembly (GO:0006336)2.67466868
126regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.66088577
127polyol catabolic process (GO:0046174)2.66022249
128regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.65927955
129meiosis I (GO:0007127)2.64833156
130histone exchange (GO:0043486)2.64823406
131rRNA catabolic process (GO:0016075)2.64349344
132gamete generation (GO:0007276)2.64309484
133regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.64022987
134phosphatidylglycerol biosynthetic process (GO:0006655)2.63974540
135Leydig cell differentiation (GO:0033327)2.63952632
136adaptation of signaling pathway (GO:0023058)2.63678121
137cilium assembly (GO:0042384)2.63476928
138histone H2A acetylation (GO:0043968)2.61916775
139mitotic sister chromatid cohesion (GO:0007064)2.60799716
140forebrain neuron differentiation (GO:0021879)2.60259497
141regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.60019305
142mitochondrial calcium ion homeostasis (GO:0051560)2.59679815
143nonmotile primary cilium assembly (GO:0035058)2.58951407
144regulation of cilium movement (GO:0003352)2.58699805
145regulation of receptor recycling (GO:0001919)2.58176473
146mitochondrion degradation (GO:0000422)2.57732726
147microtubule nucleation (GO:0007020)2.57478193
148melanocyte differentiation (GO:0030318)2.57471685
149regulation of histone phosphorylation (GO:0033127)2.55242774
150positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.55234044
151positive regulation of mitotic sister chromatid separation (GO:1901970)2.55234044
152positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.55234044
153negative regulation of cell division (GO:0051782)2.54674916
154endothelium development (GO:0003158)2.53811724
155cell-cell recognition (GO:0009988)2.53353116
156DNA replication-dependent nucleosome organization (GO:0034723)2.53290205
157DNA replication-dependent nucleosome assembly (GO:0006335)2.53290205
158histone H3-K36 demethylation (GO:0070544)2.52724444
159sphingosine metabolic process (GO:0006670)2.52108581
160positive regulation of Cdc42 GTPase activity (GO:0043089)2.51740735
161reciprocal DNA recombination (GO:0035825)2.49856342
162reciprocal meiotic recombination (GO:0007131)2.49856342
163NIK/NF-kappaB signaling (GO:0038061)2.49671956
164regulation of inclusion body assembly (GO:0090083)2.49206712
165platelet-derived growth factor receptor signaling pathway (GO:0048008)2.48812696
166microtubule polymerization or depolymerization (GO:0031109)2.48768514
167regulation of helicase activity (GO:0051095)2.47764238
168synapsis (GO:0007129)2.47645007
169oogenesis (GO:0048477)2.47631688
170ectoderm development (GO:0007398)2.46942430
171negative regulation of Rho protein signal transduction (GO:0035024)2.46535233
172protein targeting to Golgi (GO:0000042)2.45970727
173positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.45168866
174protein K48-linked deubiquitination (GO:0071108)2.44756617
175regulation of cardioblast differentiation (GO:0051890)2.43934163
176positive regulation of protein targeting to membrane (GO:0090314)2.43729171
177photoreceptor cell differentiation (GO:0046530)2.43341613
178organelle disassembly (GO:1903008)2.42854724
179peristalsis (GO:0030432)2.42776399
180positive regulation of meiotic cell cycle (GO:0051446)2.42476505
181histone H4 deacetylation (GO:0070933)2.42349174
182genitalia morphogenesis (GO:0035112)2.39708812
183water-soluble vitamin biosynthetic process (GO:0042364)2.38063826
184somite rostral/caudal axis specification (GO:0032525)2.37651827

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human3.92973859
2SMAD_19615063_ChIP-ChIP_OVARY_Human3.16092638
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.98499335
4KAP1_22055183_ChIP-Seq_ESCs_Mouse2.90673846
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.84516120
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.83070249
7E2F7_22180533_ChIP-Seq_HELA_Human2.75667223
8AR_21909140_ChIP-Seq_LNCAP_Human2.75309833
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.63917680
10ZNF274_21170338_ChIP-Seq_K562_Hela2.60004056
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57706494
12GBX2_23144817_ChIP-Seq_PC3_Human2.56331174
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.53329858
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.41357217
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.28148997
16TAF15_26573619_Chip-Seq_HEK293_Human2.26694424
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15371881
18ER_23166858_ChIP-Seq_MCF-7_Human2.15134680
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98340913
20IRF8_21731497_ChIP-ChIP_J774_Mouse1.93742663
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.92964790
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92134124
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91267864
24SUZ12_27294783_Chip-Seq_NPCs_Mouse1.90917297
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87561985
26CBP_20019798_ChIP-Seq_JUKART_Human1.86210349
27IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.86210349
28EZH2_22144423_ChIP-Seq_EOC_Human1.82510076
29P300_19829295_ChIP-Seq_ESCs_Human1.81845233
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80402922
31IRF1_19129219_ChIP-ChIP_H3396_Human1.80108882
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77268605
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72275141
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69270077
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.68892122
36GATA1_26923725_Chip-Seq_HPCs_Mouse1.68052775
37NFE2_27457419_Chip-Seq_LIVER_Mouse1.64082963
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63545177
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63390466
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60425872
41VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.60378153
42ELK1_19687146_ChIP-ChIP_HELA_Human1.59949350
43* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.58307448
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.56912612
45SMAD4_21799915_ChIP-Seq_A2780_Human1.56574979
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.55476221
47AR_25329375_ChIP-Seq_VCAP_Human1.55393986
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.54394407
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54210311
50AUTS2_25519132_ChIP-Seq_293T-REX_Human1.53669518
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53284972
52MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.52161865
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50077462
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49739109
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49679423
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49300041
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49235189
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.46234716
59LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44739467
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44479299
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.44095908
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.39150226
63CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.38786899
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38658322
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.38450528
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38436063
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.37429877
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.37020362
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.36708219
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.36072177
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35106619
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34412154
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34196959
74FOXM1_26456572_ChIP-Seq_MCF-7_Human1.33525097
75AR_21572438_ChIP-Seq_LNCaP_Human1.33388781
76* TCF4_23295773_ChIP-Seq_U87_Human1.32731397
77CDX2_22108803_ChIP-Seq_LS180_Human1.31204221
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.29930323
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27787784
80TBL1_22424771_ChIP-Seq_293T_Human1.26812258
81FUS_26573619_Chip-Seq_HEK293_Human1.25955051
82IGF1R_20145208_ChIP-Seq_DFB_Human1.25243738
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24583858
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.24148097
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.23682807
86RUNX1_26923725_Chip-Seq_HPCs_Mouse1.23627153
87AHR_22903824_ChIP-Seq_MCF-7_Human1.22530941
88TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.22316667
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21752187
90VDR_23849224_ChIP-Seq_CD4+_Human1.21098888
91STAT1_17558387_ChIP-Seq_HELA_Human1.20332928
92TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20195003
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.19051908
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17896809
95RUNX2_22187159_ChIP-Seq_PCA_Human1.17073847
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16957623
97E2F1_21310950_ChIP-Seq_MCF-7_Human1.16114842
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15890424
99FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.15657973
100NFYA_21822215_ChIP-Seq_K562_Human1.15355693
101* SMRT_27268052_Chip-Seq_Bcells_Human1.15195236
102NMYC_18555785_Chip-Seq_ESCs_Mouse1.14500264
103KLF4_18555785_Chip-Seq_ESCs_Mouse1.14483396
104* STAT3_23295773_ChIP-Seq_U87_Human1.14058741
105CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13502957
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.12814002
107HNFA_21074721_ChIP-Seq_CACO-2_Human1.11985877
108CMYC_18555785_Chip-Seq_ESCs_Mouse1.11775107
109TCF4_22108803_ChIP-Seq_LS180_Human1.11760259
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11497740
111PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.11237539
112CRX_20693478_ChIP-Seq_RETINA_Mouse1.09615605
113E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08940387
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08616531
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08616531
116BCAT_22108803_ChIP-Seq_LS180_Human1.08406416
117SALL4_22934838_ChIP-ChIP_CD34+_Human1.07893299
118STAT3_18555785_Chip-Seq_ESCs_Mouse1.07228875
119GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07166270
120NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07044764
121OCT4_18555785_Chip-Seq_ESCs_Mouse1.06904387
122NANOG_19829295_ChIP-Seq_ESCs_Human1.06480156
123SOX2_19829295_ChIP-Seq_ESCs_Human1.06480156
124PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06438179
125KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05925361
126ETV1_20927104_ChIP-Seq_GIST48_Human1.04024845
127EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03806184
128GATA3_26560356_Chip-Seq_TH1_Human1.02872406
129Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02296816
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01622407
131CBX2_22325352_ChIP-Seq_293T-Rex_Human1.00852680
132PHF8_20622853_ChIP-Seq_HELA_Human1.00578173
133FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00518719
134* RUNX_20019798_ChIP-Seq_JUKART_Human1.00247979
135EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98986634
136SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98673902
137FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98281582
138MYC_18940864_ChIP-ChIP_HL60_Human0.98260305
139VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98009746
140EWS_26573619_Chip-Seq_HEK293_Human0.97944578
141PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97822690
142GATA6_21074721_ChIP-Seq_CACO-2_Human0.97792915
143SOX2_18555785_Chip-Seq_ESCs_Mouse0.97670734
144PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97564955
145PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97001690
146CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.96900167
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96593611
148GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96260193
149SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95671175
150NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95644064
151FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95459342
152TP53_18474530_ChIP-ChIP_U2OS_Human0.95420453
153TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95136319
154MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95077598
155EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94582196
156OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94134204
157BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94056098
158VDR_22108803_ChIP-Seq_LS180_Human0.93726459
159TP63_23658742_ChIP-Seq_EP156T_Human0.93565754
160CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93251580
161HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90303139

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition6.95798019
2MP0003718_maternal_effect5.70773392
3MP0000569_abnormal_digit_pigmentation3.55399714
4MP0005395_other_phenotype3.03022128
5MP0005410_abnormal_fertilization2.98982248
6MP0003880_abnormal_central_pattern2.97400965
7MP0003693_abnormal_embryo_hatching2.93758491
8MP0002102_abnormal_ear_morphology2.90046413
9MP0002653_abnormal_ependyma_morphology2.87716131
10MP0008877_abnormal_DNA_methylation2.80099892
11MP0010094_abnormal_chromosome_stability2.77229553
12MP0008995_early_reproductive_senescence2.71751196
13MP0003646_muscle_fatigue2.69961701
14MP0003011_delayed_dark_adaptation2.63637884
15MP0003077_abnormal_cell_cycle2.53776633
16MP0003303_peritoneal_inflammation2.43500418
17MP0005408_hypopigmentation2.42199093
18MP0003111_abnormal_nucleus_morphology2.38658035
19MP0003890_abnormal_embryonic-extraembry2.32523500
20MP0009780_abnormal_chondrocyte_physiolo2.25822758
21MP0001119_abnormal_female_reproductive2.24369200
22MP0004264_abnormal_extraembryonic_tissu2.23683255
23MP0003950_abnormal_plasma_membrane2.11991627
24MP0003699_abnormal_female_reproductive2.10607164
25MP0000647_abnormal_sebaceous_gland1.99379844
26MP0001929_abnormal_gametogenesis1.95281755
27MP0003121_genomic_imprinting1.90616737
28MP0010234_abnormal_vibrissa_follicle1.81617130
29MP0000579_abnormal_nail_morphology1.66713288
30MP0000653_abnormal_sex_gland1.66053669
31MP0005253_abnormal_eye_physiology1.60678904
32MP0005310_abnormal_salivary_gland1.59779646
33MP0003252_abnormal_bile_duct1.56714078
34MP0002210_abnormal_sex_determination1.56586134
35MP0004270_analgesia1.49526505
36MP0003787_abnormal_imprinting1.49121975
37MP0005365_abnormal_bile_salt1.47541177
38MP0003937_abnormal_limbs/digits/tail_de1.46628501
39MP0010678_abnormal_skin_adnexa1.45966226
40MP0000015_abnormal_ear_pigmentation1.45263904
41MP0000566_synostosis1.40053474
42MP0004957_abnormal_blastocyst_morpholog1.39149625
43MP0002332_abnormal_exercise_endurance1.38581947
44MP0009840_abnormal_foam_cell1.38505007
45MP0002396_abnormal_hematopoietic_system1.36773824
46MP0003763_abnormal_thymus_physiology1.36142565
47MP0008260_abnormal_autophagy1.32136802
48MP0008789_abnormal_olfactory_epithelium1.30749705
49MP0001915_intracranial_hemorrhage1.27750006
50MP0005379_endocrine/exocrine_gland_phen1.26805521
51MP0006072_abnormal_retinal_apoptosis1.25905435
52MP0001486_abnormal_startle_reflex1.25213189
53MP0000383_abnormal_hair_follicle1.21964158
54MP0001984_abnormal_olfaction1.21962504
55MP0008875_abnormal_xenobiotic_pharmacok1.21919758
56MP0003806_abnormal_nucleotide_metabolis1.20381493
57MP0002019_abnormal_tumor_incidence1.18146339
58MP0005174_abnormal_tail_pigmentation1.16953662
59MP0003656_abnormal_erythrocyte_physiolo1.16698233
60MP0001188_hyperpigmentation1.16653729
61MP0008004_abnormal_stomach_pH1.14777175
62MP0002751_abnormal_autonomic_nervous1.14508857
63MP0002168_other_aberrant_phenotype1.13827262
64MP0000462_abnormal_digestive_system1.13369047
65MP0002161_abnormal_fertility/fecundity1.12785569
66MP0002098_abnormal_vibrissa_morphology1.12006821
67MP0004885_abnormal_endolymph1.11950721
68MP0008961_abnormal_basal_metabolism1.11357145
69MP0001145_abnormal_male_reproductive1.10224768
70MP0002277_abnormal_respiratory_mucosa1.08809877
71MP0000920_abnormal_myelination1.08507263
72MP0001851_eye_inflammation1.07189761
73MP0001905_abnormal_dopamine_level1.07064251
74MP0003195_calcinosis1.06979373
75MP0008007_abnormal_cellular_replicative1.05441971
76MP0000350_abnormal_cell_proliferation1.04630814
77MP0003122_maternal_imprinting1.04005936
78MP0002095_abnormal_skin_pigmentation1.02018697
79MP0005075_abnormal_melanosome_morpholog1.00593559
80MP0009384_cardiac_valve_regurgitation1.00141415
81MP0005360_urolithiasis0.97339454
82MP0003183_abnormal_peptide_metabolism0.97289998
83MP0003453_abnormal_keratinocyte_physiol0.97086685
84MP0004742_abnormal_vestibular_system0.96685229
85MP0001529_abnormal_vocalization0.95979308
86MP0002928_abnormal_bile_duct0.93830097
87MP0005666_abnormal_adipose_tissue0.93510539
88MP0008932_abnormal_embryonic_tissue0.93298944
89MP0000427_abnormal_hair_cycle0.93005638
90MP0005647_abnormal_sex_gland0.92698716
91MP0003724_increased_susceptibility_to0.92446120
92MP0001324_abnormal_eye_pigmentation0.92208486
93MP0008058_abnormal_DNA_repair0.92095815
94MP0009046_muscle_twitch0.91690064
95MP0001800_abnormal_humoral_immune0.91597741
96MP0001502_abnormal_circadian_rhythm0.91558853
97MP0002229_neurodegeneration0.91273380
98MP0003786_premature_aging0.89433250
99MP0000689_abnormal_spleen_morphology0.89138762
100MP0002085_abnormal_embryonic_tissue0.89061123
101MP0000639_abnormal_adrenal_gland0.88116644
102MP0001340_abnormal_eyelid_morphology0.88036769
103MP0002139_abnormal_hepatobiliary_system0.87634208
104MP0006292_abnormal_olfactory_placode0.86389292
105MP0005621_abnormal_cell_physiology0.86037002
106MP0003632_abnormal_nervous_system0.85088170
107MP0009333_abnormal_splenocyte_physiolog0.84931079
108MP0000465_gastrointestinal_hemorrhage0.84853974
109MP0001730_embryonic_growth_arrest0.84577587
110MP0005220_abnormal_exocrine_pancreas0.83206671
111MP0005266_abnormal_metabolism0.83167519
112MP0002723_abnormal_immune_serum0.81893780
113MP0005394_taste/olfaction_phenotype0.81444959
114MP0005499_abnormal_olfactory_system0.81444959
115MP0001485_abnormal_pinna_reflex0.81052799
116MP0002127_abnormal_cardiovascular_syste0.79705014
117MP0005671_abnormal_response_to0.77651041
118MP0003045_fibrosis0.77014731
119MP0002084_abnormal_developmental_patter0.76566707
120MP0005386_behavior/neurological_phenoty0.74048565
121MP0004924_abnormal_behavior0.74048565
122MP0002067_abnormal_sensory_capabilities0.74014839
123MP0005551_abnormal_eye_electrophysiolog0.73985431
124MP0002452_abnormal_antigen_presenting0.73636657
125MP0009763_increased_sensitivity_to0.73546047
126MP0004147_increased_porphyrin_level0.73268133
127MP0002736_abnormal_nociception_after0.72957915
128MP0003300_gastrointestinal_ulcer0.72832985
129MP0001672_abnormal_embryogenesis/_devel0.72609243
130MP0005380_embryogenesis_phenotype0.72609243
131MP0003221_abnormal_cardiomyocyte_apopto0.72425664
132MP0004185_abnormal_adipocyte_glucose0.70200070
133MP0002075_abnormal_coat/hair_pigmentati0.68993509
134MP0005389_reproductive_system_phenotype0.68843502
135MP0003698_abnormal_male_reproductive0.68192332
136MP0002282_abnormal_trachea_morphology0.68099737
137MP0005085_abnormal_gallbladder_physiolo0.68003016
138MP0004197_abnormal_fetal_growth/weight/0.67506640
139MP0002249_abnormal_larynx_morphology0.67502739
140MP0002420_abnormal_adaptive_immunity0.67428134
141MP0008057_abnormal_DNA_replication0.67212982
142MP0005023_abnormal_wound_healing0.66922046
143MP0006035_abnormal_mitochondrial_morpho0.66655182
144MP0001919_abnormal_reproductive_system0.66190754
145MP0002398_abnormal_bone_marrow0.65850610
146MP0001819_abnormal_immune_cell0.65837220
147MP0003091_abnormal_cell_migration0.65462713
148MP0009765_abnormal_xenobiotic_induced0.65341625
149MP0002557_abnormal_social/conspecific_i0.65224947
150MP0002272_abnormal_nervous_system0.65197180
151MP0006082_CNS_inflammation0.64460879
152MP0002971_abnormal_brown_adipose0.64329903
153MP0000377_abnormal_hair_follicle0.64141174
154MP0005391_vision/eye_phenotype0.61796172
155MP0009115_abnormal_fat_cell0.61648714
156MP0002160_abnormal_reproductive_system0.61551009
157MP0000372_irregular_coat_pigmentation0.61291812
158MP0004133_heterotaxia0.60299284
159MP0002796_impaired_skin_barrier0.59913278
160MP0000470_abnormal_stomach_morphology0.59678366
161MP0009764_decreased_sensitivity_to0.57999896
162MP0006054_spinal_hemorrhage0.55566628

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)6.36069915
2Breast hypoplasia (HP:0003187)4.90601235
3Chromsome breakage (HP:0040012)4.38547091
4Birth length less than 3rd percentile (HP:0003561)4.36558844
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.25134305
6Generalized hypopigmentation of hair (HP:0011358)4.09985153
7Median cleft lip (HP:0000161)4.03558241
8Papillary thyroid carcinoma (HP:0002895)3.97707701
9Thyroid-stimulating hormone excess (HP:0002925)3.91954924
10Tubulointerstitial nephritis (HP:0001970)3.79906367
11Adrenal hypoplasia (HP:0000835)3.50720845
12Deep venous thrombosis (HP:0002625)3.38595125
13Panhypogammaglobulinemia (HP:0003139)3.28325521
14Abnormality of the labia minora (HP:0012880)3.24527601
15Abnormality of the fingertips (HP:0001211)3.14790966
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.09002972
17Aplasia involving bones of the upper limbs (HP:0009823)2.96819710
18Aplasia of the phalanges of the hand (HP:0009802)2.96819710
19Aplasia involving bones of the extremities (HP:0009825)2.96819710
20Volvulus (HP:0002580)2.92826115
21Abnormal delayed hypersensitivity skin test (HP:0002963)2.89979391
22Methylmalonic acidemia (HP:0002912)2.89129528
23Chronic hepatic failure (HP:0100626)2.88457201
24Spondylolisthesis (HP:0003302)2.84974563
25Villous atrophy (HP:0011473)2.80984571
26Abnormality of small intestinal villus morphology (HP:0011472)2.80984571
27Fibular aplasia (HP:0002990)2.80270691
28Facial hemangioma (HP:0000329)2.78724439
29Renal cortical cysts (HP:0000803)2.77365999
30Premature ovarian failure (HP:0008209)2.75607393
31Agammaglobulinemia (HP:0004432)2.73830171
32Ocular albinism (HP:0001107)2.72906910
33Abnormality of chromosome stability (HP:0003220)2.71495526
34Abnormality of chromosome segregation (HP:0002916)2.71418497
35Mesomelia (HP:0003027)2.69791946
36Medial flaring of the eyebrow (HP:0010747)2.69373864
37Aplasia/hypoplasia of the uterus (HP:0008684)2.66523176
38Acute myeloid leukemia (HP:0004808)2.65732784
39Abnormal sex determination (HP:0012244)2.64285294
40Sex reversal (HP:0012245)2.64285294
41Progressive cerebellar ataxia (HP:0002073)2.60627422
42Parakeratosis (HP:0001036)2.58973556
43Aplasia/Hypoplasia of the tibia (HP:0005772)2.57762228
44Congenital primary aphakia (HP:0007707)2.57529262
45Pulmonary fibrosis (HP:0002206)2.55676441
46Medulloblastoma (HP:0002885)2.54141585
47Widely spaced teeth (HP:0000687)2.53927948
48Abnormality of macular pigmentation (HP:0008002)2.52021533
49Secondary amenorrhea (HP:0000869)2.50254008
50Patellar aplasia (HP:0006443)2.50213703
51Nephrogenic diabetes insipidus (HP:0009806)2.49336857
52Absent radius (HP:0003974)2.48757420
53Combined immunodeficiency (HP:0005387)2.48263299
54Gait imbalance (HP:0002141)2.48105691
55Hypergonadotropic hypogonadism (HP:0000815)2.47689442
56Sparse lateral eyebrow (HP:0005338)2.46435741
57Abnormality of the preputium (HP:0100587)2.46168163
58Alacrima (HP:0000522)2.45862931
59Aplasia/Hypoplasia of the uvula (HP:0010293)2.43645861
60Short tibia (HP:0005736)2.43640135
61Pancreatic cysts (HP:0001737)2.42565995
62Cerebral hypomyelination (HP:0006808)2.42215791
63Stomatitis (HP:0010280)2.41834867
64Absent forearm bone (HP:0003953)2.41609591
65Aplasia involving forearm bones (HP:0009822)2.41609591
66Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.38246570
67Degeneration of the lateral corticospinal tracts (HP:0002314)2.38246570
68Abnormality of the renal cortex (HP:0011035)2.38220677
693-Methylglutaconic aciduria (HP:0003535)2.36859680
70Progressive inability to walk (HP:0002505)2.36376578
71Aplasia/Hypoplasia of the breasts (HP:0010311)2.33897171
72Congenital sensorineural hearing impairment (HP:0008527)2.31865619
73Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.31657009
74Morphological abnormality of the inner ear (HP:0011390)2.30628920
75Lip pit (HP:0100267)2.30424098
76Retinal atrophy (HP:0001105)2.27740806
77Retinal dysplasia (HP:0007973)2.27212360
78Truncal obesity (HP:0001956)2.25310171
79Postaxial foot polydactyly (HP:0001830)2.25091185
80Genital tract atresia (HP:0001827)2.23698555
81Oligodactyly (hands) (HP:0001180)2.23140160
82Capillary hemangiomas (HP:0005306)2.21977026
83Colitis (HP:0002583)2.20465822
84Aplasia/Hypoplasia of the patella (HP:0006498)2.20159032
85Meckel diverticulum (HP:0002245)2.18500669
86Postaxial hand polydactyly (HP:0001162)2.18241066
87Oligodactyly (HP:0012165)2.17706269
88Abnormality of lateral ventricle (HP:0030047)2.17426213
89Abnormality of midbrain morphology (HP:0002418)2.17200013
90Molar tooth sign on MRI (HP:0002419)2.17200013
91Cortical dysplasia (HP:0002539)2.11279893
92Poor coordination (HP:0002370)2.11245676
93Ectopic kidney (HP:0000086)2.11018282
94Flat capital femoral epiphysis (HP:0003370)2.10854299
95Prostate neoplasm (HP:0100787)2.10053806
96Anhidrosis (HP:0000970)2.09345098
97Infertility (HP:0000789)2.08979207
98Attenuation of retinal blood vessels (HP:0007843)2.08704029
99Myelodysplasia (HP:0002863)2.07075624
100Iris hypopigmentation (HP:0007730)2.06910818
101Intrahepatic cholestasis (HP:0001406)2.06523188
102Hypoplastic labia majora (HP:0000059)2.05683876
103Adactyly (HP:0009776)2.05604927
104Spinal muscular atrophy (HP:0007269)2.05162016
105Methylmalonic aciduria (HP:0012120)2.04598320
106Short foot (HP:0001773)2.04450647
107Abnormal spermatogenesis (HP:0008669)2.03834241
108Breast aplasia (HP:0100783)2.03774172
109Aplasia/Hypoplasia of the tongue (HP:0010295)2.03505011
110Sensory axonal neuropathy (HP:0003390)2.03114208
111Vaginal atresia (HP:0000148)2.02821816
112Hypoplasia of the fovea (HP:0007750)2.02120914
113Aplasia/Hypoplasia of the fovea (HP:0008060)2.02120914
114Inability to walk (HP:0002540)2.02104315
115Congenital hepatic fibrosis (HP:0002612)2.01705137
116Abnormality of the ileum (HP:0001549)2.01102450
117Abnormality of the corticospinal tract (HP:0002492)2.01024832
118Azoospermia (HP:0000027)2.00960030
119Shawl scrotum (HP:0000049)2.00414890
120Depressed nasal tip (HP:0000437)1.99938570
121Pancreatic fibrosis (HP:0100732)1.99833446
122Supernumerary spleens (HP:0009799)1.99658407
123Duodenal stenosis (HP:0100867)1.98256902
124Small intestinal stenosis (HP:0012848)1.98256902
125Neonatal respiratory distress (HP:0002643)1.97831675
126Preaxial hand polydactyly (HP:0001177)1.96765738
127Ectropion (HP:0000656)1.95529336
128Recurrent skin infections (HP:0001581)1.93199735
129Nephronophthisis (HP:0000090)1.92006428
130Encephalitis (HP:0002383)1.91974628
131Long nose (HP:0003189)1.91403736
132Wrist flexion contracture (HP:0001239)1.91282276
133Recurrent bacterial skin infections (HP:0005406)1.90850498
134Neoplasm of striated muscle (HP:0009728)1.90246823
135Cupped ear (HP:0000378)1.89670568
136Rhabdomyosarcoma (HP:0002859)1.89428759
137T lymphocytopenia (HP:0005403)1.89142443
138Thyroiditis (HP:0100646)1.88560433
139Albinism (HP:0001022)1.88254945
140Posterior subcapsular cataract (HP:0007787)1.87405877
141Chorioretinal atrophy (HP:0000533)1.86739219
142Absent speech (HP:0001344)1.86550829
143Abnormality of the vitamin B12 metabolism (HP:0004341)1.85448652
144Aplasia/Hypoplasia of the sternum (HP:0006714)1.84988321
145Generalized hypopigmentation (HP:0007513)1.84888995
146Labial hypoplasia (HP:0000066)1.84361922
147Hypoplastic pelvis (HP:0008839)1.84193347
148Recurrent cutaneous fungal infections (HP:0011370)1.83601531
149Chronic mucocutaneous candidiasis (HP:0002728)1.83601531
150Abnormality of cochlea (HP:0000375)1.83568688
151Abnormality of the renal medulla (HP:0100957)1.83033162
152Hyperventilation (HP:0002883)1.81827439
153Abnormality of the labia majora (HP:0012881)1.80998611
154Abnormal hair whorl (HP:0010721)1.80634293
155Facial cleft (HP:0002006)1.80381421
156Recurrent viral infections (HP:0004429)1.79365878
157Abnormality of the hepatic vasculature (HP:0006707)1.78757710
158Bony spicule pigmentary retinopathy (HP:0007737)1.78171985
159Abnormality of vitamin B metabolism (HP:0004340)1.78073560
160Heterotopia (HP:0002282)1.77695222
161IgM deficiency (HP:0002850)1.76863800
162Severe visual impairment (HP:0001141)1.76328376
163Decreased lacrimation (HP:0000633)1.75620671
164Bone marrow hypocellularity (HP:0005528)1.74208907
165Abnormality of the fovea (HP:0000493)1.73992031
166Abnormality of T cell number (HP:0011839)1.73804342
167Camptodactyly of toe (HP:0001836)1.72631212
168Gonadotropin excess (HP:0000837)1.72587859
169Curly hair (HP:0002212)1.72482329
170Severe combined immunodeficiency (HP:0004430)1.70941539
171Cone-rod dystrophy (HP:0000548)1.70178318
172Aplasia/Hypoplasia involving the musculature (HP:0001460)1.69566166
173Clubbing of toes (HP:0100760)1.69540289
174Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.69130584
175Insulin-resistant diabetes mellitus (HP:0000831)1.69127582
176Sloping forehead (HP:0000340)1.68086169
177Spastic gait (HP:0002064)1.66996122
178Intestinal atresia (HP:0011100)1.66878674
179Thyroid carcinoma (HP:0002890)1.66823257
180Abnormality of eosinophils (HP:0001879)1.66383665
181Paraparesis (HP:0002385)1.65793543
182Hepatoblastoma (HP:0002884)1.65536428
183Hypoplastic nipples (HP:0002557)1.65516218
184Abnormality of the hip-girdle musculature (HP:0001445)1.64279098
185Abnormality of the musculature of the pelvis (HP:0001469)1.64279098
186Intellectual disability, moderate (HP:0002342)1.64159248
187Narrow forehead (HP:0000341)1.62716965
188Large for gestational age (HP:0001520)1.62009915
189Horizontal nystagmus (HP:0000666)1.61957552
190Abnormal biliary tract physiology (HP:0012439)1.61518025
191Bile duct proliferation (HP:0001408)1.61518025

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K65.69963367
2FER4.01988460
3EEF2K3.58327559
4WNK33.24425633
5TAOK33.11717698
6LATS13.09361201
7TRIM283.08749755
8MOS3.06819022
9FES3.02214308
10FRK2.99727600
11TNIK2.92835826
12TTK2.66539389
13ERBB42.61848345
14STK162.60734263
15BMPR22.57316958
16PLK22.51727551
17PLK42.49745522
18MST42.49168219
19STK102.41273964
20MAP4K22.41101719
21MAP3K132.37468079
22BMPR1B2.19681284
23MAPKAPK32.10658476
24CDK32.08046096
25CDC72.06672940
26LATS22.06111686
27RAF12.00995213
28CASK1.94745765
29KSR21.85465289
30CAMKK21.84584971
31MUSK1.76791857
32STK38L1.76579585
33BRAF1.76331738
34NLK1.65490591
35ERBB31.63476164
36STK31.60750069
37TESK21.58340443
38MAPKAPK51.52144291
39AKT31.51665403
40PAK61.50206355
41CSNK1G11.49194979
42NEK21.44657451
43RPS6KA41.43616337
44CSNK1G31.42187085
45PINK11.41534425
46TRPM71.39187085
47MET1.34685498
48IRAK11.34604815
49CSNK1A1L1.33784516
50ARAF1.32845266
51TAOK11.31481664
52MAP3K91.30552633
53MELK1.29594729
54NUAK11.27029491
55CAMK11.26111031
56TXK1.24779686
57INSRR1.18818671
58PAK31.18148550
59CHEK21.14027713
60DYRK21.11673676
61PRKCE1.08390106
62CSNK1G21.07155804
63MAPK131.06692225
64CDK81.02512414
65PTK2B1.01273025
66MAP2K40.97109680
67PRKD20.95839334
68CDK90.95656113
69PKN10.94592911
70OXSR10.91679158
71MAP3K40.86595006
72FGR0.86014303
73MATK0.83671270
74DMPK0.83606287
75STK390.83062715
76SIK30.83031010
77PBK0.79957264
78BUB10.79910616
79PLK10.79832023
80MAP3K120.77474376
81CAMK40.75654025
82MAP2K30.75339302
83PRKAA20.74732263
84SGK20.72992085
85EIF2AK30.71345298
86GRK10.70677071
87CAMK1G0.70196086
88MAP3K80.69066113
89CAMK1D0.68815600
90SIK20.68451912
91MAP3K50.68352386
92SRPK10.68283562
93PNCK0.67548348
94RPS6KB20.65288290
95MARK20.65055266
96MARK10.62687289
97MAPK150.62433671
98ERBB20.60063223
99TSSK60.59174745
100BRD40.58257621
101ACVR1B0.57866123
102MAP2K70.55981712
103ADRBK20.55975978
104ZAP700.55531969
105PRKCI0.54731333
106RET0.53721618
107BCR0.53554232
108ABL20.53468172
109WNK10.50172989
110MARK30.49783508
111ITK0.49360088
112YES10.47959460
113MAP4K10.47908379
114MKNK20.47443362
115PRKAA10.47393676
116PLK30.47108598
117EPHB10.46827474
118MAPK120.46595517
119IKBKB0.46295641
120AURKB0.46185461
121ADRBK10.46013520
122MAPK110.44590303
123EPHA30.44551876
124CHUK0.44101241
125BRSK20.42130357
126GRK70.40728747
127CSNK1A10.39784840
128DYRK1B0.39479219
129MAPK70.39162868
130CHEK10.38610310
131STK40.38175135
132CCNB10.38099915
133JAK10.37753763
134EGFR0.35745981
135PRKCZ0.35672309
136NEK60.35563102
137JAK30.34096879
138PDK20.33949867
139PIM10.33198559
140AURKA0.31909357
141IRAK30.31735262
142PRKCQ0.31426590
143DYRK1A0.31418716
144IKBKE0.30830177
145STK380.30475216
146TYRO30.30372862
147CDK150.28199958
148ABL10.27828335
149ATM0.27443486
150DYRK30.27158505
151CLK10.26256046
152CSNK1D0.25911474
153CSK0.24533367
154KSR10.24430717
155TEC0.24230342
156EIF2AK10.24008950
157MAP2K60.22847945
158CDK180.22429475
159CDK11A0.22361757
160MAP3K10.21960760
161MAP2K10.21409679

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.72147692
2Basal transcription factors_Homo sapiens_hsa030223.10410553
3Ether lipid metabolism_Homo sapiens_hsa005653.03551108
4Circadian rhythm_Homo sapiens_hsa047102.99900498
5Cell cycle_Homo sapiens_hsa041102.89591489
6Ovarian steroidogenesis_Homo sapiens_hsa049132.64944142
7RNA degradation_Homo sapiens_hsa030182.43159743
8Protein export_Homo sapiens_hsa030602.17479168
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.06009152
10Linoleic acid metabolism_Homo sapiens_hsa005912.03858494
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.01040342
12Fanconi anemia pathway_Homo sapiens_hsa034602.00980135
13Proteasome_Homo sapiens_hsa030501.93074482
14Homologous recombination_Homo sapiens_hsa034401.80504853
15Legionellosis_Homo sapiens_hsa051341.78860091
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.77309128
17Pancreatic cancer_Homo sapiens_hsa052121.75729686
18Collecting duct acid secretion_Homo sapiens_hsa049661.70974401
19Non-homologous end-joining_Homo sapiens_hsa034501.70195532
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62171774
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61318079
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.52827351
23Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.51507195
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48978278
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48429482
26Steroid biosynthesis_Homo sapiens_hsa001001.46229513
27TGF-beta signaling pathway_Homo sapiens_hsa043501.44025109
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.43874642
29p53 signaling pathway_Homo sapiens_hsa041151.43300083
30Synaptic vesicle cycle_Homo sapiens_hsa047211.42840416
31Lysine degradation_Homo sapiens_hsa003101.40671373
32Selenocompound metabolism_Homo sapiens_hsa004501.40334774
33Glycerophospholipid metabolism_Homo sapiens_hsa005641.40019480
34Arachidonic acid metabolism_Homo sapiens_hsa005901.33964639
35Caffeine metabolism_Homo sapiens_hsa002321.30805148
36Primary immunodeficiency_Homo sapiens_hsa053401.29588460
37Sphingolipid metabolism_Homo sapiens_hsa006001.24298733
38Fatty acid biosynthesis_Homo sapiens_hsa000611.20644499
39GABAergic synapse_Homo sapiens_hsa047271.20013287
40Dorso-ventral axis formation_Homo sapiens_hsa043201.18885146
41MicroRNAs in cancer_Homo sapiens_hsa052061.15713969
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13784452
43Fatty acid elongation_Homo sapiens_hsa000621.13747848
44mRNA surveillance pathway_Homo sapiens_hsa030151.11174256
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06772273
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06664438
47Herpes simplex infection_Homo sapiens_hsa051681.04961729
48Taste transduction_Homo sapiens_hsa047421.04057334
49Oocyte meiosis_Homo sapiens_hsa041141.03752512
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99973350
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98070023
52Hedgehog signaling pathway_Homo sapiens_hsa043400.97237466
53Retinol metabolism_Homo sapiens_hsa008300.96340897
54Base excision repair_Homo sapiens_hsa034100.95120095
55Inositol phosphate metabolism_Homo sapiens_hsa005620.94476016
56FoxO signaling pathway_Homo sapiens_hsa040680.93814196
57Regulation of autophagy_Homo sapiens_hsa041400.92105810
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90286683
59Prolactin signaling pathway_Homo sapiens_hsa049170.90129622
60Propanoate metabolism_Homo sapiens_hsa006400.89939078
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89294929
62Shigellosis_Homo sapiens_hsa051310.88965901
63Long-term depression_Homo sapiens_hsa047300.88494966
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86249798
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86140201
66Tight junction_Homo sapiens_hsa045300.85738920
67Olfactory transduction_Homo sapiens_hsa047400.85435072
68Viral carcinogenesis_Homo sapiens_hsa052030.85314663
69RNA polymerase_Homo sapiens_hsa030200.80505745
70ABC transporters_Homo sapiens_hsa020100.79707261
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.79528154
72Other glycan degradation_Homo sapiens_hsa005110.78610252
73Small cell lung cancer_Homo sapiens_hsa052220.77985115
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.77950504
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76841139
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72119230
77Hippo signaling pathway_Homo sapiens_hsa043900.71492049
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70799101
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70611374
80Glycerolipid metabolism_Homo sapiens_hsa005610.70421006
81Prostate cancer_Homo sapiens_hsa052150.68601070
82Vibrio cholerae infection_Homo sapiens_hsa051100.67900408
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66578038
84Folate biosynthesis_Homo sapiens_hsa007900.65417238
85RNA transport_Homo sapiens_hsa030130.65210009
86GnRH signaling pathway_Homo sapiens_hsa049120.64233950
87Histidine metabolism_Homo sapiens_hsa003400.62914200
88Renal cell carcinoma_Homo sapiens_hsa052110.62694650
89Notch signaling pathway_Homo sapiens_hsa043300.62627513
90Colorectal cancer_Homo sapiens_hsa052100.62576647
91Choline metabolism in cancer_Homo sapiens_hsa052310.62340983
92AMPK signaling pathway_Homo sapiens_hsa041520.61418248
93Glutathione metabolism_Homo sapiens_hsa004800.60820675
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60275761
95Dopaminergic synapse_Homo sapiens_hsa047280.59041257
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58139701
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57899084
98Ras signaling pathway_Homo sapiens_hsa040140.57267528
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57082495
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.57059238
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56891185
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56396493
103Arginine and proline metabolism_Homo sapiens_hsa003300.55249700
104N-Glycan biosynthesis_Homo sapiens_hsa005100.53637365
105Vitamin digestion and absorption_Homo sapiens_hsa049770.53057982
106Type II diabetes mellitus_Homo sapiens_hsa049300.52741206
107VEGF signaling pathway_Homo sapiens_hsa043700.52712386
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52492693
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52304971
110Adherens junction_Homo sapiens_hsa045200.51949149
111Epstein-Barr virus infection_Homo sapiens_hsa051690.51761332
112Hepatitis C_Homo sapiens_hsa051600.51659838
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51573904
114Osteoclast differentiation_Homo sapiens_hsa043800.51115614
115Influenza A_Homo sapiens_hsa051640.51071101
116B cell receptor signaling pathway_Homo sapiens_hsa046620.50511275
117T cell receptor signaling pathway_Homo sapiens_hsa046600.50289085
118Malaria_Homo sapiens_hsa051440.49786790
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.48935774
120Measles_Homo sapiens_hsa051620.48652860
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48575921
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47488790
123MAPK signaling pathway_Homo sapiens_hsa040100.47286192
124Endocytosis_Homo sapiens_hsa041440.47191362
125TNF signaling pathway_Homo sapiens_hsa046680.46384870
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.46384212
127Chemical carcinogenesis_Homo sapiens_hsa052040.45633892
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45598768
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.45226576
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44585208
131Arginine biosynthesis_Homo sapiens_hsa002200.44494464
132Hepatitis B_Homo sapiens_hsa051610.43164786
133Morphine addiction_Homo sapiens_hsa050320.43008417
134Leishmaniasis_Homo sapiens_hsa051400.41341428
135Axon guidance_Homo sapiens_hsa043600.40743671
136Phototransduction_Homo sapiens_hsa047440.40149721
137Thyroid cancer_Homo sapiens_hsa052160.39552130
138Purine metabolism_Homo sapiens_hsa002300.39170740
139Nicotine addiction_Homo sapiens_hsa050330.38716930
140Complement and coagulation cascades_Homo sapiens_hsa046100.38436109
141Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37444814
142Chronic myeloid leukemia_Homo sapiens_hsa052200.37170720
143Peroxisome_Homo sapiens_hsa041460.37050684
144beta-Alanine metabolism_Homo sapiens_hsa004100.36622874
145Phospholipase D signaling pathway_Homo sapiens_hsa040720.36462995
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35444309

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