WDR24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.22198204
2proline biosynthetic process (GO:0006561)5.09775053
3DNA strand elongation involved in DNA replication (GO:0006271)4.60373048
4GDP-mannose metabolic process (GO:0019673)4.59944975
5ribosomal small subunit assembly (GO:0000028)4.49909112
6mannose metabolic process (GO:0006013)4.39230026
7DNA unwinding involved in DNA replication (GO:0006268)4.37977676
8folic acid-containing compound biosynthetic process (GO:0009396)4.34882944
9DNA strand elongation (GO:0022616)4.32298725
10negative regulation of cell size (GO:0045792)4.20945529
11nucleobase biosynthetic process (GO:0046112)4.14826571
12formation of translation preinitiation complex (GO:0001731)4.09840213
13protein retention in ER lumen (GO:0006621)4.07793742
14telomere maintenance via semi-conservative replication (GO:0032201)4.02326338
15purine nucleobase biosynthetic process (GO:0009113)3.95467259
16negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.87369943
17IMP biosynthetic process (GO:0006188)3.84348563
18regulation of mammary gland epithelial cell proliferation (GO:0033599)3.81013084
19DNA replication initiation (GO:0006270)3.80805952
20UV protection (GO:0009650)3.76455954
21maturation of SSU-rRNA (GO:0030490)3.75120812
22maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.70364799
23negative regulation of erythrocyte differentiation (GO:0045647)3.70161038
24viral transcription (GO:0019083)3.67687187
25snRNA metabolic process (GO:0016073)3.67366858
26regulation of chromatin binding (GO:0035561)3.66732921
27retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.60067462
28spliceosomal tri-snRNP complex assembly (GO:0000244)3.58109183
29apoptotic process involved in morphogenesis (GO:0060561)3.58046021
30regulation of NFAT protein import into nucleus (GO:0051532)3.53685892
31intracellular estrogen receptor signaling pathway (GO:0030520)3.52176611
32translational elongation (GO:0006414)3.49318681
33translational termination (GO:0006415)3.48742028
34proline metabolic process (GO:0006560)3.47572068
35protein insertion into membrane (GO:0051205)3.46986498
36modulation by virus of host process (GO:0019054)3.46012591
37telomere maintenance via recombination (GO:0000722)3.40921737
38deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.40828663
39pentose-phosphate shunt (GO:0006098)3.35408464
40nucleosome disassembly (GO:0006337)3.32254714
41protein-DNA complex disassembly (GO:0032986)3.32254714
42adherens junction assembly (GO:0034333)3.31738317
433-UTR-mediated mRNA stabilization (GO:0070935)3.28190070
44protein localization to kinetochore (GO:0034501)3.25856792
45folic acid metabolic process (GO:0046655)3.24706990
46snRNA processing (GO:0016180)3.23332088
47translesion synthesis (GO:0019985)3.23310654
48translational initiation (GO:0006413)3.23225434
49modulation by symbiont of host cellular process (GO:0044068)3.22218056
50semaphorin-plexin signaling pathway (GO:0071526)3.21755700
51negative regulation of viral release from host cell (GO:1902187)3.21498845
52focal adhesion assembly (GO:0048041)3.18278130
53cell-substrate adherens junction assembly (GO:0007045)3.18278130
54SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.18178589
55IMP metabolic process (GO:0046040)3.16422072
56mitotic recombination (GO:0006312)3.15876882
57histone H2A acetylation (GO:0043968)3.14894179
58DNA replication checkpoint (GO:0000076)3.14627072
59pteridine-containing compound biosynthetic process (GO:0042559)3.12187732
60glucose catabolic process (GO:0006007)3.11273754
61mitotic nuclear envelope reassembly (GO:0007084)3.10801401
62nuclear envelope reassembly (GO:0031468)3.10801401
63telomere maintenance via telomere lengthening (GO:0010833)3.10661253
64antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.07113053
65antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.07113053
66protein targeting to ER (GO:0045047)3.05836936
67cotranslational protein targeting to membrane (GO:0006613)3.05658609
68positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.05525167
69nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.05321029
70ribosomal large subunit biogenesis (GO:0042273)3.05253043
71mitotic chromosome condensation (GO:0007076)3.05093032
72embryonic process involved in female pregnancy (GO:0060136)3.03730608
73adenine nucleotide transport (GO:0051503)3.00368249
74DNA replication-dependent nucleosome assembly (GO:0006335)3.00241922
75DNA replication-dependent nucleosome organization (GO:0034723)3.00241922
76glycine metabolic process (GO:0006544)3.00106737
77nucleotide-excision repair, DNA gap filling (GO:0006297)2.99505891
78negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.98409791
79activation of Rac GTPase activity (GO:0032863)2.97063082
80ribosomal small subunit biogenesis (GO:0042274)2.97032799
81mitotic nuclear envelope disassembly (GO:0007077)2.97030242
82pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.96822715
83regulation of glucose import in response to insulin stimulus (GO:2001273)2.96204466
84misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.94028042
85basement membrane organization (GO:0071711)2.93252670
86spliceosomal snRNP assembly (GO:0000387)2.93065773
87retrograde transport, endosome to Golgi (GO:0042147)2.92046892
88postreplication repair (GO:0006301)2.91697610
89DNA duplex unwinding (GO:0032508)2.90997867
90DNA strand renaturation (GO:0000733)2.90766127
91ribonucleoprotein complex biogenesis (GO:0022613)2.90262607
92ribosome biogenesis (GO:0042254)2.89660495
93histone H4 deacetylation (GO:0070933)2.88798575
94tetrahydrofolate metabolic process (GO:0046653)2.88617199
95protein localization to endoplasmic reticulum (GO:0070972)2.88473854
96establishment of protein localization to endoplasmic reticulum (GO:0072599)2.88170368
97DNA geometric change (GO:0032392)2.86105669
98purine ribonucleotide transport (GO:0015868)2.85269366
99NADPH regeneration (GO:0006740)2.83766844
100positive regulation of Cdc42 GTPase activity (GO:0043089)2.81206291
101viral life cycle (GO:0019058)2.81036769
102tRNA aminoacylation for protein translation (GO:0006418)2.80210443
103cellular protein complex disassembly (GO:0043624)2.78493366
104negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.77968679
105activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.77814810
106amino acid activation (GO:0043038)2.76564025
107tRNA aminoacylation (GO:0043039)2.76564025
108regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.76229524
109pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.75869222
110oxaloacetate metabolic process (GO:0006107)2.75353372
111regulation of type I interferon-mediated signaling pathway (GO:0060338)2.75001719
112mRNA cleavage (GO:0006379)2.74922664
113negative regulation of RNA splicing (GO:0033119)2.74535208
114Golgi transport vesicle coating (GO:0048200)2.73710088
115COPI coating of Golgi vesicle (GO:0048205)2.73710088
116mitochondrial fusion (GO:0008053)2.73632176
117membrane disassembly (GO:0030397)2.73618849
118nuclear envelope disassembly (GO:0051081)2.73618849
119protein localization to chromosome, centromeric region (GO:0071459)2.73245365
120planar cell polarity pathway involved in neural tube closure (GO:0090179)2.73147428
121rRNA processing (GO:0006364)2.73141404
122protein complex disassembly (GO:0043241)2.73082491
123regulation of ARF GTPase activity (GO:0032312)2.72246409
124negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.71679823
125somatic hypermutation of immunoglobulin genes (GO:0016446)2.69401587
126somatic diversification of immune receptors via somatic mutation (GO:0002566)2.69401587
127proteasome assembly (GO:0043248)2.68590188
128epithelial cell differentiation involved in prostate gland development (GO:0060742)2.68570180
129L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.68525198
130positive regulation of nuclease activity (GO:0032075)2.68365973
131modulation by virus of host morphology or physiology (GO:0019048)2.68090568
132anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.67863327
133peptidyl-arginine omega-N-methylation (GO:0035247)2.66540130
134stress fiber assembly (GO:0043149)2.66343053
135regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.66086233
136tRNA methylation (GO:0030488)2.64503978
137dosage compensation (GO:0007549)2.64312351
138rRNA metabolic process (GO:0016072)2.64210932
139regulation of cholesterol biosynthetic process (GO:0045540)2.64152535
140response to laminar fluid shear stress (GO:0034616)2.63878027
141activation of MAPKKK activity (GO:0000185)2.63150057
142pseudouridine synthesis (GO:0001522)2.62742065
143regulation of T-helper 2 cell differentiation (GO:0045628)2.62643617
144translation (GO:0006412)2.62561052
145methionine biosynthetic process (GO:0009086)2.62388755
146positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.62385882
147regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.61324532
148iron-sulfur cluster assembly (GO:0016226)2.61083222
149metallo-sulfur cluster assembly (GO:0031163)2.61083222
150barbed-end actin filament capping (GO:0051016)2.60828575
151positive regulation of protein sumoylation (GO:0033235)2.60741044
152maternal placenta development (GO:0001893)2.60627401
153macromolecular complex disassembly (GO:0032984)2.59815156
154purine nucleotide transport (GO:0015865)2.59218485
155establishment of integrated proviral latency (GO:0075713)2.58858921
156protein maturation by protein folding (GO:0022417)2.58690001
157ncRNA 3-end processing (GO:0043628)2.58352919
158folic acid-containing compound metabolic process (GO:0006760)2.57931033
159nuclear-transcribed mRNA catabolic process (GO:0000956)2.57779685
160NADH metabolic process (GO:0006734)2.57601086
161serine family amino acid biosynthetic process (GO:0009070)2.56672792
162peptidyl-arginine methylation (GO:0018216)2.56173226
163peptidyl-arginine N-methylation (GO:0035246)2.56173226
164negative regulation of ligase activity (GO:0051352)2.56131974
165negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.56131974
166L-methionine salvage (GO:0071267)2.56025456
167L-methionine biosynthetic process (GO:0071265)2.56025456
168amino acid salvage (GO:0043102)2.56025456
169methionine metabolic process (GO:0006555)2.55343868
170cell-cell junction maintenance (GO:0045217)2.54882192
171histone H3-K36 demethylation (GO:0070544)2.54746230
172heterochromatin organization (GO:0070828)2.54337520
173regulation of translational fidelity (GO:0006450)2.54203108
174antigen processing and presentation of endogenous antigen (GO:0019883)2.54010120
175termination of RNA polymerase II transcription (GO:0006369)2.53946083
176cellular response to virus (GO:0098586)2.53890794
177mitotic metaphase plate congression (GO:0007080)2.52807163
178positive regulation of histone deacetylation (GO:0031065)2.52228631
179adenosine receptor signaling pathway (GO:0001973)2.51575246
180atrioventricular valve morphogenesis (GO:0003181)2.50234470
181regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.46636019
182histone arginine methylation (GO:0034969)2.46088519
183cytoskeletal anchoring at plasma membrane (GO:0007016)2.45459349
184rRNA transcription (GO:0009303)2.44906099
185poly(A)+ mRNA export from nucleus (GO:0016973)2.44387164
186protein localization to endosome (GO:0036010)2.44089501
187mitochondrial DNA metabolic process (GO:0032042)2.41961168
188regulation of nuclease activity (GO:0032069)2.39135953
189RNA stabilization (GO:0043489)2.38984418
190mRNA stabilization (GO:0048255)2.38984418
191thymic T cell selection (GO:0045061)2.38980970

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.96904941
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.01501858
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.49682038
4LXR_22292898_ChIP-Seq_THP-1_Human2.77413286
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69067850
6MYC_18358816_ChIP-ChIP_MESCs_Mouse2.62234929
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.60948386
8* ETS1_20019798_ChIP-Seq_JURKAT_Human2.58683332
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.51979339
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.50616580
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45195505
12* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.41325381
13* GABP_17652178_ChIP-ChIP_JURKAT_Human2.40580991
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.39510089
15MYC_22102868_ChIP-Seq_BL_Human2.35091786
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29386288
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28306908
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.25941510
19* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.25787254
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.22500171
21* XRN2_22483619_ChIP-Seq_HELA_Human2.17258988
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.16031598
23RACK7_27058665_Chip-Seq_MCF-7_Human2.11905471
24KDM2B_26808549_Chip-Seq_SUP-B15_Human2.11037398
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03689924
26P68_20966046_ChIP-Seq_HELA_Human2.02339392
27CIITA_25753668_ChIP-Seq_RAJI_Human2.00221720
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.99339895
29NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96195624
30KDM2B_26808549_Chip-Seq_DND41_Human1.95937900
31* FOXP3_21729870_ChIP-Seq_TREG_Human1.93297987
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91541306
33* VDR_23849224_ChIP-Seq_CD4+_Human1.90899059
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89428994
35* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87558157
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.84956798
37* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.83393229
38GABP_19822575_ChIP-Seq_HepG2_Human1.83117613
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.83002383
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.82709046
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.78972577
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76435936
43VDR_21846776_ChIP-Seq_THP-1_Human1.74496575
44* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74261553
45ZNF263_19887448_ChIP-Seq_K562_Human1.73803942
46DCP1A_22483619_ChIP-Seq_HELA_Human1.73133778
47* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70192077
48ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.64583899
49* SMC4_20622854_ChIP-Seq_HELA_Human1.62881131
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.62341738
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.62261177
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55344174
53VDR_24763502_ChIP-Seq_THP-1_Human1.55196529
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55073408
55SA1_27219007_Chip-Seq_ERYTHROID_Human1.54725880
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54663680
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52542630
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51880525
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50397806
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50267667
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49073959
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48407608
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47855140
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46425357
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45911719
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45379230
67EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43570828
68BCOR_27268052_Chip-Seq_Bcells_Human1.42777886
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.42498036
70* TTF2_22483619_ChIP-Seq_HELA_Human1.42267876
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.41971649
72KDM5A_27292631_Chip-Seq_BREAST_Human1.41913318
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.40880018
74* KDM2B_26808549_Chip-Seq_K562_Human1.40686283
75* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40035868
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39840861
77HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38816666
78* CREB1_26743006_Chip-Seq_LNCaP_Human1.38215948
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36262988
80BCL6_27268052_Chip-Seq_Bcells_Human1.35892621
81TP63_17297297_ChIP-ChIP_HaCaT_Human1.35780726
82* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34065253
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33629786
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33417797
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32702161
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31716867
87UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31263068
88AR_21909140_ChIP-Seq_LNCAP_Human1.31121029
89ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31041341
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.30945058
91NCOR1_26117541_ChIP-Seq_K562_Human1.29688253
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27288707
93SRF_21415370_ChIP-Seq_HL-1_Mouse1.26885038
94PHF8_20622854_ChIP-Seq_HELA_Human1.26482953
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26391620
96RARB_24833708_ChIP-Seq_LIVER_Mouse1.23545956
97RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23371292
98RARA_24833708_ChIP-Seq_LIVER_Mouse1.22735329
99KDM2B_26808549_Chip-Seq_JURKAT_Human1.22579606
100MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.22272320
101STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21038978
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20568635
103CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20162405
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20144478
105PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20024614
106CTCF_21964334_Chip-Seq_Bcells_Human1.19910838
107* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19717687
108TFEB_21752829_ChIP-Seq_HELA_Human1.19090733
109STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18020608
110KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17940320
111FOXP1_21924763_ChIP-Seq_HESCs_Human1.16502478
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16354056
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14583940
114CTCF_27219007_Chip-Seq_Bcells_Human1.14258754
115* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14224736
116SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13280907
117DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11890150
118ATF3_27146783_Chip-Seq_COLON_Human1.11831744
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11009253
120E2F1_20622854_ChIP-Seq_HELA_Human1.10913624
121TP53_22127205_ChIP-Seq_IMR90_Human1.10429215
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09964746
123ESR2_21235772_ChIP-Seq_MCF-7_Human1.09950210
124ETS1_21867929_ChIP-Seq_TH2_Mouse1.09696316
125SPI1_23547873_ChIP-Seq_NB4_Human1.08955286
126* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07732214
127KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06850592
128GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06768707
129CTCF_21964334_ChIP-Seq_BJAB-B_Human1.05927572
130IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05493256
131POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05485978
132CTCF_26484167_Chip-Seq_Bcells_Mouse1.05045168
133P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04299440
134SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04183555
135UTX_26944678_Chip-Seq_JUKART_Human1.04058888
136MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03969386
137BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02641357
138PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02512134
139CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00956248
140SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00882303
141PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.99582414
142MAF_26560356_Chip-Seq_TH1_Human0.98310657
143NOTCH1_21737748_ChIP-Seq_TLL_Human0.96687314
144CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95934068
145ELF1_20517297_ChIP-Seq_JURKAT_Human0.95666277
146PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95517319
147KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95505731
148CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94137232
149SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93676738
150CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90762001
151* MAF_26560356_Chip-Seq_TH2_Human0.89659511
152SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.88993597
153RUNX1_22412390_ChIP-Seq_EML_Mouse0.88828681
154ELK1_19687146_ChIP-ChIP_HELA_Human0.88674702
155CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88594018
156TCF7_22412390_ChIP-Seq_EML_Mouse0.87954927
157E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87473814
158NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87058472

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.75272875
2MP0002396_abnormal_hematopoietic_system3.79077799
3MP0003705_abnormal_hypodermis_morpholog3.72805459
4MP0005451_abnormal_body_composition3.62753915
5MP0010094_abnormal_chromosome_stability3.60479447
6MP0005058_abnormal_lysosome_morphology3.43644964
7MP0003111_abnormal_nucleus_morphology3.33982969
8MP0004957_abnormal_blastocyst_morpholog3.27084400
9MP0005076_abnormal_cell_differentiation3.21694529
10MP0003077_abnormal_cell_cycle2.92429175
11MP0008058_abnormal_DNA_repair2.83212387
12MP0008260_abnormal_autophagy2.75454692
13MP0001849_ear_inflammation2.32253842
14MP0003806_abnormal_nucleotide_metabolis2.27074607
15MP0008007_abnormal_cellular_replicative2.22873584
16MP0000751_myopathy2.17654631
17MP0002139_abnormal_hepatobiliary_system2.16635325
18MP0005365_abnormal_bile_salt2.13794599
19MP0000678_abnormal_parathyroid_gland2.13377917
20MP0003763_abnormal_thymus_physiology2.12667299
21MP0008057_abnormal_DNA_replication2.09835741
22MP0004808_abnormal_hematopoietic_stem2.09555753
23MP0004185_abnormal_adipocyte_glucose2.06999074
24MP0001545_abnormal_hematopoietic_system2.05044065
25MP0005397_hematopoietic_system_phenotyp2.05044065
26MP0004858_abnormal_nervous_system2.04060679
27MP0009840_abnormal_foam_cell2.03013130
28MP0001730_embryonic_growth_arrest2.00421199
29MP0005409_darkened_coat_color1.97092476
30MP0004233_abnormal_muscle_weight1.91906897
31MP0003453_abnormal_keratinocyte_physiol1.83509599
32MP0005360_urolithiasis1.80963783
33MP0005085_abnormal_gallbladder_physiolo1.79752239
34MP0000003_abnormal_adipose_tissue1.73433547
35MP0010352_gastrointestinal_tract_polyps1.70489866
36MP0002249_abnormal_larynx_morphology1.69768430
37MP0005501_abnormal_skin_physiology1.68489755
38MP0002398_abnormal_bone_marrow1.68489486
39MP0006036_abnormal_mitochondrial_physio1.62787459
40MP0000490_abnormal_crypts_of1.61752607
41MP0005171_absent_coat_pigmentation1.60152998
42MP0000350_abnormal_cell_proliferation1.58578070
43MP0002019_abnormal_tumor_incidence1.58211333
44MP0008877_abnormal_DNA_methylation1.58034044
45MP0001348_abnormal_lacrimal_gland1.56812819
46MP0000689_abnormal_spleen_morphology1.53522970
47MP0002722_abnormal_immune_system1.52835700
48MP0005330_cardiomyopathy1.51999301
49MP0000313_abnormal_cell_death1.50416424
50MP0009333_abnormal_splenocyte_physiolog1.47893251
51MP0000703_abnormal_thymus_morphology1.47853139
52MP0000358_abnormal_cell_content/1.46301822
53MP0000750_abnormal_muscle_regeneration1.44761177
54MP0001661_extended_life_span1.44680290
55MP0002080_prenatal_lethality1.44569349
56MP0000537_abnormal_urethra_morphology1.43349642
57MP0005375_adipose_tissue_phenotype1.41759111
58MP0004147_increased_porphyrin_level1.41567891
59MP0000747_muscle_weakness1.40071287
60MP0006054_spinal_hemorrhage1.39767705
61MP0005666_abnormal_adipose_tissue1.39302529
62MP0006035_abnormal_mitochondrial_morpho1.36108511
63MP0000685_abnormal_immune_system1.35322557
64MP0010329_abnormal_lipoprotein_level1.34306068
65MP0002796_impaired_skin_barrier1.34173930
66MP0002429_abnormal_blood_cell1.33654943
67MP0000609_abnormal_liver_physiology1.31653473
68MP0003656_abnormal_erythrocyte_physiolo1.31613126
69MP0002653_abnormal_ependyma_morphology1.28904199
70MP0001697_abnormal_embryo_size1.27327715
71MP0003091_abnormal_cell_migration1.25642774
72MP0005220_abnormal_exocrine_pancreas1.24674169
73MP0005083_abnormal_biliary_tract1.23853307
74MP0008875_abnormal_xenobiotic_pharmacok1.23159141
75MP0002254_reproductive_system_inflammat1.22119615
76MP0004381_abnormal_hair_follicle1.21570039
77MP0000716_abnormal_immune_system1.20402484
78MP0000681_abnormal_thyroid_gland1.20019182
79MP0000598_abnormal_liver_morphology1.18973331
80MP0001835_abnormal_antigen_presentation1.18890262
81MP0003566_abnormal_cell_adhesion1.17743972
82MP0001764_abnormal_homeostasis1.17605230
83MP0008961_abnormal_basal_metabolism1.15893373
84MP0001672_abnormal_embryogenesis/_devel1.15875176
85MP0005380_embryogenesis_phenotype1.15875176
86MP0010307_abnormal_tumor_latency1.15388425
87MP0005671_abnormal_response_to1.15215295
88MP0000759_abnormal_skeletal_muscle1.14537893
89MP0003984_embryonic_growth_retardation1.14411780
90MP0009931_abnormal_skin_appearance1.13873174
91MP0003315_abnormal_perineum_morphology1.13093327
92MP0002088_abnormal_embryonic_growth/wei1.12045769
93MP0003191_abnormal_cellular_cholesterol1.11689108
94MP0008932_abnormal_embryonic_tissue1.10835551
95MP0001666_abnormal_nutrient_absorption1.08021007
96MP0000733_abnormal_muscle_development1.07651043
97MP0001800_abnormal_humoral_immune1.06373745
98MP0004264_abnormal_extraembryonic_tissu1.05419984
99MP0009278_abnormal_bone_marrow1.05349794
100MP0000858_altered_metastatic_potential1.05264061
101MP0003186_abnormal_redox_activity1.04896846
102MP0003183_abnormal_peptide_metabolism1.04418742
103MP0005319_abnormal_enzyme/_coenzyme1.04304221
104MP0001873_stomach_inflammation1.03265550
105MP0002420_abnormal_adaptive_immunity1.02286287
106MP0010234_abnormal_vibrissa_follicle1.01847603
107MP0002089_abnormal_postnatal_growth/wei1.01528959
108MP0001819_abnormal_immune_cell1.00842251
109MP0003866_abnormal_defecation1.00670887
110MP0005174_abnormal_tail_pigmentation0.99526133
111MP0005310_abnormal_salivary_gland0.99360381
112MP0002086_abnormal_extraembryonic_tissu0.98675456
113MP0002060_abnormal_skin_morphology0.97822815
114MP0003329_amyloid_beta_deposits0.97819490
115MP0000013_abnormal_adipose_tissue0.97541321
116MP0004947_skin_inflammation0.97082378
117MP0005075_abnormal_melanosome_morpholog0.94543233
118MP0002877_abnormal_melanocyte_morpholog0.93796200
119MP0005464_abnormal_platelet_physiology0.93296096
120MP0005623_abnormal_meninges_morphology0.92688286
121MP0009643_abnormal_urine_homeostasis0.92396511
122MP0003172_abnormal_lysosome_physiology0.91756099
123MP0002723_abnormal_immune_serum0.91630505
124MP0003303_peritoneal_inflammation0.89734844
125MP0003786_premature_aging0.88913349
126MP0005423_abnormal_somatic_nervous0.88803863
127MP0002166_altered_tumor_susceptibility0.85480487
128MP0004087_abnormal_muscle_fiber0.85330945
129MP0001188_hyperpigmentation0.84879085
130MP0005384_cellular_phenotype0.84857741
131MP0002084_abnormal_developmental_patter0.84652439
132MP0004197_abnormal_fetal_growth/weight/0.83736438
133MP0005025_abnormal_response_to0.83383121
134MP0002085_abnormal_embryonic_tissue0.83271076
135MP0002452_abnormal_antigen_presenting0.82737028
136MP0001929_abnormal_gametogenesis0.81846135
137MP0000477_abnormal_intestine_morphology0.81431281
138MP0010630_abnormal_cardiac_muscle0.80002811
139MP0008469_abnormal_protein_level0.79965195
140MP0003123_paternal_imprinting0.79801747
141MP0003436_decreased_susceptibility_to0.79224037
142MP0005584_abnormal_enzyme/coenzyme_acti0.79144717
143MP0010030_abnormal_orbit_morphology0.78032168
144MP0005332_abnormal_amino_acid0.77617660
145MP0003279_aneurysm0.77478599
146MP0010155_abnormal_intestine_physiology0.76808453
147MP0002822_catalepsy0.76292038
148MP0001944_abnormal_pancreas_morphology0.76018042
149MP0009672_abnormal_birth_weight0.75433925
150MP0000371_diluted_coat_color0.74664802
151MP0005621_abnormal_cell_physiology0.74583412
152MP0009785_altered_susceptibility_to0.74115165
153MP0005636_abnormal_mineral_homeostasis0.74012587
154MP0001216_abnormal_epidermal_layer0.72774030
155MP0009384_cardiac_valve_regurgitation0.71518919
156MP0002970_abnormal_white_adipose0.68951283
157MP0001915_intracranial_hemorrhage0.64527572
158MP0005670_abnormal_white_adipose0.63004490

Predicted human phenotypes

RankGene SetZ-score
1Ulnar bowing (HP:0003031)4.06396878
2Testicular atrophy (HP:0000029)3.78861382
3Abnormal number of erythroid precursors (HP:0012131)3.71844740
4Abnormality of cells of the erythroid lineage (HP:0012130)3.62659008
5Thin bony cortex (HP:0002753)3.37146581
6Thrombocytosis (HP:0001894)3.34492567
7IgM deficiency (HP:0002850)3.33911618
8Aplastic anemia (HP:0001915)3.30294520
9Myopathic facies (HP:0002058)3.29435045
10Oral leukoplakia (HP:0002745)3.24957071
11Selective tooth agenesis (HP:0001592)3.21084901
12Distal upper limb amyotrophy (HP:0007149)3.19899185
13Upper limb amyotrophy (HP:0009129)3.19899185
14Hemorrhage of the eye (HP:0011885)3.16113345
15Degeneration of anterior horn cells (HP:0002398)3.04169445
16Abnormality of the anterior horn cell (HP:0006802)3.04169445
1711 pairs of ribs (HP:0000878)3.03876458
18Ependymoma (HP:0002888)3.00175244
19Broad distal phalanx of finger (HP:0009836)2.78134129
20Stridor (HP:0010307)2.75884692
21Reticulocytopenia (HP:0001896)2.74146290
22Microretrognathia (HP:0000308)2.73206481
23Annular pancreas (HP:0001734)2.71826295
24Hypobetalipoproteinemia (HP:0003563)2.64308218
25Multiple enchondromatosis (HP:0005701)2.64084164
26Birth length less than 3rd percentile (HP:0003561)2.60610471
27Reduced antithrombin III activity (HP:0001976)2.59262803
28Abnormality of the heme biosynthetic pathway (HP:0010472)2.58471372
29Turricephaly (HP:0000262)2.56272722
30Centrally nucleated skeletal muscle fibers (HP:0003687)2.55408709
31Broad face (HP:0000283)2.54890162
32Long palpebral fissure (HP:0000637)2.54184859
33Abnormality of the thoracic spine (HP:0100711)2.53496077
34Recurrent bronchitis (HP:0002837)2.52990615
35Thoracic kyphosis (HP:0002942)2.52754935
36Obstructive sleep apnea (HP:0002870)2.51645579
37Nasal polyposis (HP:0100582)2.49970797
38Distal lower limb amyotrophy (HP:0008944)2.49546050
39Achilles tendon contracture (HP:0001771)2.47808158
40Colon cancer (HP:0003003)2.45946175
41Atrophy/Degeneration involving motor neurons (HP:0007373)2.44269442
42Microvesicular hepatic steatosis (HP:0001414)2.44050277
43Vertebral compression fractures (HP:0002953)2.43525275
44Increased connective tissue (HP:0009025)2.41640532
45Progressive external ophthalmoplegia (HP:0000590)2.39913666
46Hyperacusis (HP:0010780)2.39711210
47Cerebral hypomyelination (HP:0006808)2.37367395
48Progressive muscle weakness (HP:0003323)2.36711998
49Abnormality of monocarboxylic acid metabolism (HP:0010996)2.35451687
50Limb hypertonia (HP:0002509)2.34944931
51Difficulty climbing stairs (HP:0003551)2.34282087
52Biconcave vertebral bodies (HP:0004586)2.33157923
53Spastic diplegia (HP:0001264)2.30404009
54Cellular immunodeficiency (HP:0005374)2.30385392
55Facial hemangioma (HP:0000329)2.26169622
56Abnormality of the columella (HP:0009929)2.25348210
57Abnormality of the motor neurons (HP:0002450)2.24589288
58Abnormal neuron morphology (HP:0012757)2.24589288
59Abnormality of the fingertips (HP:0001211)2.23238562
60Macrocytic anemia (HP:0001972)2.22765385
61Late onset (HP:0003584)2.21172255
62Pallor (HP:0000980)2.19995070
63Easy fatigability (HP:0003388)2.19925867
64Vaginal fistula (HP:0004320)2.19782649
65Hyperbilirubinemia (HP:0002904)2.18555901
66Hypoplasia of the thymus (HP:0000778)2.17771328
67Hypoplasia of the capital femoral epiphysis (HP:0003090)2.17429621
68Abnormality of pyrimidine metabolism (HP:0004353)2.17336445
69Abnormality of aromatic amino acid family metabolism (HP:0004338)2.16797205
70Poikiloderma (HP:0001029)2.16736281
71Abnormality of the Achilles tendon (HP:0005109)2.15376276
72Diaphragmatic weakness (HP:0009113)2.15152915
73Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.15150460
74Decreased activity of mitochondrial respiratory chain (HP:0008972)2.15150460
75Rough bone trabeculation (HP:0100670)2.13803173
76Exercise-induced myalgia (HP:0003738)2.13099236
77Hyperglycinemia (HP:0002154)2.11301485
78Pancytopenia (HP:0001876)2.11287416
79Intestinal fistula (HP:0100819)2.10151271
80Basal cell carcinoma (HP:0002671)2.09609177
81Cerebral aneurysm (HP:0004944)2.07967342
82Type I transferrin isoform profile (HP:0003642)2.06861719
83Cholelithiasis (HP:0001081)2.06623551
84Abnormality of reticulocytes (HP:0004312)2.05911850
85Abnormality of T cell physiology (HP:0011840)2.04582772
86Pointed chin (HP:0000307)2.04030623
87Abnormality of the lower motor neuron (HP:0002366)2.02977863
88Colitis (HP:0002583)2.02936027
89Chronic otitis media (HP:0000389)2.02497572
90Abnormality of the nasal mucosa (HP:0000433)2.02413500
91Anteriorly placed anus (HP:0001545)2.01276260
92Cervical subluxation (HP:0003308)2.00849074
93Abnormality of T cells (HP:0002843)2.00234132
94Trismus (HP:0000211)1.99639783
95Thin ribs (HP:0000883)1.99372604
96Self-mutilation (HP:0000742)1.98936849
97Medulloblastoma (HP:0002885)1.97850633
98Increased serum lactate (HP:0002151)1.97650152
99Ankle clonus (HP:0011448)1.97405384
100Flattened epiphyses (HP:0003071)1.96705680
101Disproportionate tall stature (HP:0001519)1.94339546
102Megaloblastic anemia (HP:0001889)1.93802678
103Atelectasis (HP:0100750)1.93748526
104Amyotrophic lateral sclerosis (HP:0007354)1.93481223
105Gout (HP:0001997)1.93387913
106External ophthalmoplegia (HP:0000544)1.93311244
107Bulbar palsy (HP:0001283)1.93270539
108Missing ribs (HP:0000921)1.92107515
109Bronchitis (HP:0012387)1.91698115
110Neoplasm of the pancreas (HP:0002894)1.90070305
111Prominent nose (HP:0000448)1.89328253
112Prominent metopic ridge (HP:0005487)1.89189011
113Squamous cell carcinoma (HP:0002860)1.88878029
114Spinal rigidity (HP:0003306)1.88317025
115Adenoma sebaceum (HP:0009720)1.87140009
116Angiofibromas (HP:0010615)1.87140009
117Secondary amenorrhea (HP:0000869)1.85458282
118Agnosia (HP:0010524)1.85192816
119Hyperammonemia (HP:0001987)1.84633463
120Nonimmune hydrops fetalis (HP:0001790)1.84606966
121Insomnia (HP:0100785)1.84029710
122Axonal loss (HP:0003447)1.83597195
123Petechiae (HP:0000967)1.82806391
124Hyperglycinuria (HP:0003108)1.80834208
125Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80787334
126Abnormal protein N-linked glycosylation (HP:0012347)1.80787334
127Abnormal protein glycosylation (HP:0012346)1.80787334
128Abnormal glycosylation (HP:0012345)1.80787334
129Congenital hip dislocation (HP:0001374)1.80498334
130Cholecystitis (HP:0001082)1.79818840
131Abnormal gallbladder physiology (HP:0012438)1.79818840
132Unsteady gait (HP:0002317)1.79056373
133High anterior hairline (HP:0009890)1.79046772
134Premature skin wrinkling (HP:0100678)1.77998195
135Breast hypoplasia (HP:0003187)1.77879225
136Pelvic girdle muscle weakness (HP:0003749)1.77424391
137Patellar aplasia (HP:0006443)1.76789437
138Abnormal spermatogenesis (HP:0008669)1.76645873
139Delayed epiphyseal ossification (HP:0002663)1.76537222
140Flat acetabular roof (HP:0003180)1.76203579
141Increased variability in muscle fiber diameter (HP:0003557)1.76009359
142Spina bifida occulta (HP:0003298)1.75868374
143Ketosis (HP:0001946)1.75761906
144Bone marrow hypocellularity (HP:0005528)1.75723614
145Tongue fasciculations (HP:0001308)1.75615247
146Ragged-red muscle fibers (HP:0003200)1.75080678
147Abnormality of cells of the lymphoid lineage (HP:0012140)1.73878512
148Spinal muscular atrophy (HP:0007269)1.73642831
149Myelodysplasia (HP:0002863)1.73099335
150Hypoglycemic coma (HP:0001325)1.72283786
151Abnormality of sulfur amino acid metabolism (HP:0004339)1.72047602
152Rib fusion (HP:0000902)1.71853820
153Mesangial abnormality (HP:0001966)1.71466979
154Abnormality of the gallbladder (HP:0005264)1.70642270
155Hand muscle atrophy (HP:0009130)1.70527553
156Acute lymphatic leukemia (HP:0006721)1.70218330
157Loss of speech (HP:0002371)1.70054346
158Joint stiffness (HP:0001387)1.69763552
159Lymphoma (HP:0002665)1.69072868
160Generalized amyotrophy (HP:0003700)1.68674439
161Cellulitis (HP:0100658)1.68652163
162Gastrointestinal inflammation (HP:0004386)1.68549011
163Hypertensive crisis (HP:0100735)1.68327858
164Nuclear cataract (HP:0100018)1.68296495
165Neuronal loss in central nervous system (HP:0002529)1.68181148
166Large eyes (HP:0001090)1.67880561
167Reticulocytosis (HP:0001923)1.67529977
168Bowing of the arm (HP:0006488)1.66915126
169Bowed forearm bones (HP:0003956)1.66915126
170Recurrent viral infections (HP:0004429)1.66111315
171Hepatic necrosis (HP:0002605)1.66029842
172Urethral obstruction (HP:0000796)1.65931724
173Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.65483911
174Absent epiphyses (HP:0010577)1.65483911
175Long eyelashes (HP:0000527)1.65160412
176Capillary hemangiomas (HP:0005306)1.64697733
177Genu recurvatum (HP:0002816)1.64650187
178Elbow flexion contracture (HP:0002987)1.64031882
179Gastrointestinal dysmotility (HP:0002579)1.64024272
180Shallow orbits (HP:0000586)1.63733959
181Lower limb amyotrophy (HP:0007210)1.62282677
182Bowel incontinence (HP:0002607)1.61044325
183Abnormal gallbladder morphology (HP:0012437)1.59407834
184Neonatal onset (HP:0003623)1.59046319
185Abnormal large intestine physiology (HP:0012700)1.58210202
186Abnormality of the distal phalanx of the thumb (HP:0009617)1.57071021
187Hypercortisolism (HP:0001578)1.57002110
188Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.56987693

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.67381788
2EEF2K3.05503391
3WEE13.03479457
4CDK123.01241079
5PRPF4B2.92041920
6ICK2.83903354
7NEK12.79671712
8SCYL22.76254142
9STK162.71525830
10BUB12.69496078
11NEK22.55776719
12TRIB32.54154380
13CDC72.52108148
14MAP4K12.51574311
15ERN12.38046627
16IRAK32.30592307
17MAP3K102.16574553
18BRSK22.05102366
19PASK1.92658799
20CCNB11.92284284
21PKN21.92129996
22BCKDK1.88879790
23MAP3K121.88768605
24NME21.88064268
25EIF2AK11.85577604
26FLT31.76889648
27TSSK61.64908672
28DAPK11.63307145
29PAK41.57528005
30ACVR1B1.54779502
31ARAF1.54217849
32ATR1.53713562
33MAPK151.53605616
34PRKD21.53197206
35PRKD31.52449201
36DYRK31.52388483
37EPHA21.46057226
38IRAK21.44558471
39RPS6KB21.42306175
40MAP3K111.40941383
41TAOK21.38505700
42CAMK1D1.36374479
43KDR1.36207882
44TESK21.35132762
45GRK61.33681876
46MARK21.33178303
47BRSK11.32554125
48CDK71.32315130
49MAP2K31.31328665
50TGFBR11.30962214
51PDK41.29943950
52PDK31.29943950
53TLK11.25434144
54LRRK21.23439516
55SRPK11.22108580
56TTK1.21435686
57MAPKAPK31.20961335
58CDK41.20846713
59STK101.16393940
60VRK11.15594621
61RPS6KA41.12889735
62EIF2AK31.12293155
63TESK11.07810525
64TYK21.06827315
65PLK11.06645831
66CDK191.06556589
67AURKB1.03411078
68PDPK11.02951833
69KIT1.01393412
70PIM20.99117863
71ZAP700.97545549
72CSF1R0.95825731
73MST1R0.92331149
74BTK0.89714812
75TNK20.89269685
76CDK80.88881870
77MAP3K80.84074651
78CDC42BPA0.82176246
79MAP3K10.78527678
80PDGFRA0.76704305
81PIM10.76461803
82CAMK1G0.75770762
83IRAK40.74840320
84CHEK10.71491675
85BMX0.69740922
86JAK30.68908647
87AURKA0.68666973
88FGFR40.67037613
89SYK0.65950054
90EPHB10.64358695
91MAPK110.62048655
92SIK30.61800458
93CAMKK20.60240721
94TBK10.59425580
95TAOK10.59174374
96MAP3K50.57732729
97MAPK120.56623178
98CHEK20.55522710
99CSNK2A20.55322610
100HIPK20.53405254
101CDK90.52603505
102LMTK20.52196207
103SIK10.51648543
104CDK20.50848311
105TTN0.50818702
106KSR20.49415189
107PRKCI0.48135300
108MAP3K130.47895962
109BRAF0.47755306
110ILK0.47403262
111RIPK10.47032027
112BLK0.46380872
113ITK0.46117838
114PTK20.45645974
115RAF10.45523832
116NTRK10.45496310
117AKT20.44499918
118PDK10.42980975
119TEC0.42657861
120PTK60.42619250
121RPS6KL10.42402177
122RPS6KC10.42402177
123SIK20.41534543
124RPS6KA20.41265174
125RPS6KA10.40404498
126DYRK1B0.40367321
127ATM0.40188709
128CDK11A0.39513884
129RIPK40.38460545
130RPS6KA60.38229136
131MET0.37732257
132PAK10.37185949
133MTOR0.36623556
134MAP3K30.36555199
135CSNK2A10.36398798
136MELK0.35572836
137LYN0.35434179
138PRKD10.35424078
139CDK150.35377351
140TAOK30.35349058
141MAP2K20.34860147
142CDK60.34087037
143MAPK100.34079131
144TXK0.33281016
145MAP3K70.32680059
146MAPK80.32596425
147DAPK30.32520654
148MAPKAPK20.32494477
149CDK140.32438632

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.61711495
2Mismatch repair_Homo sapiens_hsa034303.48169891
3Ribosome_Homo sapiens_hsa030102.90816413
4Base excision repair_Homo sapiens_hsa034102.84092851
5Sulfur relay system_Homo sapiens_hsa041222.77491134
6Proteasome_Homo sapiens_hsa030502.73849275
7One carbon pool by folate_Homo sapiens_hsa006702.69554459
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.59983650
9Spliceosome_Homo sapiens_hsa030402.58137332
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.43050723
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.41495681
12Nucleotide excision repair_Homo sapiens_hsa034202.27936538
13RNA polymerase_Homo sapiens_hsa030202.23398822
14RNA transport_Homo sapiens_hsa030132.22626340
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.21600784
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.20837432
17Pyrimidine metabolism_Homo sapiens_hsa002402.17724074
18Selenocompound metabolism_Homo sapiens_hsa004502.16682897
19Homologous recombination_Homo sapiens_hsa034402.11394280
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.07035229
21Notch signaling pathway_Homo sapiens_hsa043302.05094196
22Biosynthesis of amino acids_Homo sapiens_hsa012301.90237272
23Non-homologous end-joining_Homo sapiens_hsa034501.89594616
24Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.87635524
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.83736701
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.82082879
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.74775010
28Pentose phosphate pathway_Homo sapiens_hsa000301.65838023
29Bladder cancer_Homo sapiens_hsa052191.62846670
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.58419782
31Cell cycle_Homo sapiens_hsa041101.57974568
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.57314193
33Folate biosynthesis_Homo sapiens_hsa007901.56616180
34Carbon metabolism_Homo sapiens_hsa012001.53663264
35VEGF signaling pathway_Homo sapiens_hsa043701.49805973
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.28799117
37RNA degradation_Homo sapiens_hsa030181.27733661
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.26944776
39Endometrial cancer_Homo sapiens_hsa052131.24603243
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.22074876
41Insulin signaling pathway_Homo sapiens_hsa049101.20566452
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.16498195
43AMPK signaling pathway_Homo sapiens_hsa041521.16246521
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.13942415
45Longevity regulating pathway - mammal_Homo sapiens_hsa042111.11910336
46Pyruvate metabolism_Homo sapiens_hsa006201.11890169
47Antigen processing and presentation_Homo sapiens_hsa046121.11596992
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10732311
49Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09245489
50Pancreatic cancer_Homo sapiens_hsa052121.07581069
51Primary immunodeficiency_Homo sapiens_hsa053401.06865394
52p53 signaling pathway_Homo sapiens_hsa041151.04410370
53Fanconi anemia pathway_Homo sapiens_hsa034601.02324135
54Lysosome_Homo sapiens_hsa041420.99332600
55Systemic lupus erythematosus_Homo sapiens_hsa053220.98636463
56Inositol phosphate metabolism_Homo sapiens_hsa005620.97207323
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96536107
58Purine metabolism_Homo sapiens_hsa002300.94339295
59ErbB signaling pathway_Homo sapiens_hsa040120.93697434
60mRNA surveillance pathway_Homo sapiens_hsa030150.90952605
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90168405
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88548604
63Hepatitis C_Homo sapiens_hsa051600.87757744
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87691736
65N-Glycan biosynthesis_Homo sapiens_hsa005100.85720031
66Hepatitis B_Homo sapiens_hsa051610.85615723
67Epstein-Barr virus infection_Homo sapiens_hsa051690.85476294
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85208969
69Fatty acid degradation_Homo sapiens_hsa000710.85152135
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84938469
71Fructose and mannose metabolism_Homo sapiens_hsa000510.84322017
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.80702627
73Insulin resistance_Homo sapiens_hsa049310.79721156
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79595822
75Prion diseases_Homo sapiens_hsa050200.77875014
76Fatty acid biosynthesis_Homo sapiens_hsa000610.77440145
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77184067
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77120284
79Caffeine metabolism_Homo sapiens_hsa002320.77041802
80Glioma_Homo sapiens_hsa052140.76921891
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74599036
82Basal transcription factors_Homo sapiens_hsa030220.74382800
83Colorectal cancer_Homo sapiens_hsa052100.72182519
84Prostate cancer_Homo sapiens_hsa052150.71681335
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69962601
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69770589
87Endocytosis_Homo sapiens_hsa041440.69696087
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67858897
89Tryptophan metabolism_Homo sapiens_hsa003800.66659778
90Herpes simplex infection_Homo sapiens_hsa051680.63825410
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.63284716
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62488779
93Vibrio cholerae infection_Homo sapiens_hsa051100.62482668
94Viral carcinogenesis_Homo sapiens_hsa052030.62410403
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59253185
96Influenza A_Homo sapiens_hsa051640.58686668
97Regulation of autophagy_Homo sapiens_hsa041400.57237211
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.56675008
99Small cell lung cancer_Homo sapiens_hsa052220.56563279
100Alcoholism_Homo sapiens_hsa050340.55946963
101Galactose metabolism_Homo sapiens_hsa000520.54438540
102Propanoate metabolism_Homo sapiens_hsa006400.54399299
103Fat digestion and absorption_Homo sapiens_hsa049750.54092000
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53161153
105Osteoclast differentiation_Homo sapiens_hsa043800.53100166
106Choline metabolism in cancer_Homo sapiens_hsa052310.52904282
107GnRH signaling pathway_Homo sapiens_hsa049120.52629436
108Sphingolipid metabolism_Homo sapiens_hsa006000.52487770
109MicroRNAs in cancer_Homo sapiens_hsa052060.52202265
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49268145
111Renal cell carcinoma_Homo sapiens_hsa052110.48691564
112Arginine biosynthesis_Homo sapiens_hsa002200.47276449
113Legionellosis_Homo sapiens_hsa051340.47082502
114Other glycan degradation_Homo sapiens_hsa005110.45262566
115TNF signaling pathway_Homo sapiens_hsa046680.45150838
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.44875718
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44695744
118Salmonella infection_Homo sapiens_hsa051320.43918569
119Prolactin signaling pathway_Homo sapiens_hsa049170.42673995
120Thyroid cancer_Homo sapiens_hsa052160.42481458
121Acute myeloid leukemia_Homo sapiens_hsa052210.42141246
122Shigellosis_Homo sapiens_hsa051310.42127816
123Oocyte meiosis_Homo sapiens_hsa041140.42043646
124Estrogen signaling pathway_Homo sapiens_hsa049150.42006550
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41436648
126Metabolic pathways_Homo sapiens_hsa011000.41421622
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41319396
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40513256
129Renin-angiotensin system_Homo sapiens_hsa046140.40214981
130Lysine degradation_Homo sapiens_hsa003100.39495260
131HTLV-I infection_Homo sapiens_hsa051660.38840582
132Measles_Homo sapiens_hsa051620.37865583
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37228824
134Apoptosis_Homo sapiens_hsa042100.37018638
135Phenylalanine metabolism_Homo sapiens_hsa003600.36071967
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.34618801
137ABC transporters_Homo sapiens_hsa020100.33567874
138beta-Alanine metabolism_Homo sapiens_hsa004100.30554454
139Protein export_Homo sapiens_hsa030600.29542190
140Glucagon signaling pathway_Homo sapiens_hsa049220.26666706
141B cell receptor signaling pathway_Homo sapiens_hsa046620.26159185
142Glutathione metabolism_Homo sapiens_hsa004800.25861629
143Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24468198
144Peroxisome_Homo sapiens_hsa041460.23185456
145Fatty acid metabolism_Homo sapiens_hsa012120.22987844
146Parkinsons disease_Homo sapiens_hsa050120.22709118
147Sulfur metabolism_Homo sapiens_hsa009200.22640883
148Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22040120
149Non-small cell lung cancer_Homo sapiens_hsa052230.20886173
150Butanoate metabolism_Homo sapiens_hsa006500.20829969
151Vitamin B6 metabolism_Homo sapiens_hsa007500.19808097
152Huntingtons disease_Homo sapiens_hsa050160.17617149
153Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17370695
154mTOR signaling pathway_Homo sapiens_hsa041500.17118263
155Chronic myeloid leukemia_Homo sapiens_hsa052200.16081654

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