WDR25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)7.38454292
2maintenance of protein location in nucleus (GO:0051457)6.80568375
3somite rostral/caudal axis specification (GO:0032525)6.64597061
4regulation of mammary gland epithelial cell proliferation (GO:0033599)6.50065751
5protein localization to kinetochore (GO:0034501)6.39039662
6negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.38336628
7negative regulation of epidermis development (GO:0045683)6.28383054
8regulation of nuclear cell cycle DNA replication (GO:0033262)6.16393366
9regulation of telomere maintenance via telomerase (GO:0032210)6.11409782
10regulation of response to osmotic stress (GO:0047484)5.84585038
11negative regulation of telomerase activity (GO:0051974)5.80712349
12histone H4-K8 acetylation (GO:0043982)5.78981909
13histone H4-K5 acetylation (GO:0043981)5.78981909
14proteasome assembly (GO:0043248)5.77828381
15negative regulation of cell cycle G2/M phase transition (GO:1902750)5.73781160
16histone H4-K12 acetylation (GO:0043983)5.65692260
17regulation of MHC class I biosynthetic process (GO:0045343)5.63554849
18negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.55293088
19rRNA transcription (GO:0009303)5.53227730
20muscle organ morphogenesis (GO:0048644)5.46345233
21mitotic sister chromatid segregation (GO:0000070)5.15376819
22notochord development (GO:0030903)5.00024016
23cytidine deamination (GO:0009972)4.87890247
24cytidine metabolic process (GO:0046087)4.87890247
25cytidine catabolic process (GO:0006216)4.87890247
26negative regulation of epidermal cell differentiation (GO:0045605)4.86354238
27interferon-gamma production (GO:0032609)4.80724270
28negative regulation of telomere maintenance (GO:0032205)4.74029499
29heterochromatin organization (GO:0070828)4.73423661
30rRNA methylation (GO:0031167)4.72421505
31protein localization to chromosome, centromeric region (GO:0071459)4.69047214
32regulation of cilium movement (GO:0003352)4.65681205
33positive regulation of DNA-dependent DNA replication (GO:2000105)4.63783575
34hormone catabolic process (GO:0042447)4.61649953
35phenol-containing compound catabolic process (GO:0019336)4.54687962
36coenzyme catabolic process (GO:0009109)4.48612981
37nucleoside transmembrane transport (GO:1901642)4.34437738
38quinone metabolic process (GO:1901661)4.32445248
39response to dietary excess (GO:0002021)4.28636847
40regulation of translation in response to stress (GO:0043555)4.28172577
41histone H4-K16 acetylation (GO:0043984)4.27315319
42sister chromatid segregation (GO:0000819)4.24212491
43nuclear pore complex assembly (GO:0051292)4.23052389
44DNA replication-dependent nucleosome assembly (GO:0006335)4.21830043
45DNA replication-dependent nucleosome organization (GO:0034723)4.21830043
46rRNA modification (GO:0000154)4.18947313
47acrosome reaction (GO:0007340)4.18385089
48branching involved in mammary gland duct morphogenesis (GO:0060444)4.13116467
49regulation of apoptotic process involved in morphogenesis (GO:1902337)4.12241821
50chromatin assembly (GO:0031497)4.11846975
51primitive streak formation (GO:0090009)4.11519710
52DNA replication checkpoint (GO:0000076)4.04447924
53positive regulation of mitochondrial fission (GO:0090141)3.90389169
54microtubule severing (GO:0051013)3.88259027
55maintenance of protein localization in organelle (GO:0072595)3.83764069
56lipopolysaccharide biosynthetic process (GO:0009103)3.76095471
57cellular modified amino acid catabolic process (GO:0042219)3.74689080
58nuclear pore organization (GO:0006999)3.72292666
59intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.71944825
60metallo-sulfur cluster assembly (GO:0031163)3.71430604
61iron-sulfur cluster assembly (GO:0016226)3.71430604
62protein polyglutamylation (GO:0018095)3.70453107
63mitochondrion distribution (GO:0048311)3.69256641
64ubiquinone biosynthetic process (GO:0006744)3.67443156
65cell fate commitment involved in formation of primary germ layer (GO:0060795)3.67184591
66piRNA metabolic process (GO:0034587)3.65500531
67regulation of telomere maintenance (GO:0032204)3.65433060
68binding of sperm to zona pellucida (GO:0007339)3.65168398
69positive regulation of protein deacetylation (GO:0090312)3.63738095
70pyrimidine ribonucleoside catabolic process (GO:0046133)3.62067352
71regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.60497729
72sperm-egg recognition (GO:0035036)3.56773171
73cardiovascular system development (GO:0072358)3.55526182
74cullin deneddylation (GO:0010388)3.54389460
75male meiosis I (GO:0007141)3.51280477
76sperm motility (GO:0030317)3.48550519
77GDP-mannose metabolic process (GO:0019673)3.47948279
78tachykinin receptor signaling pathway (GO:0007217)3.46730064
79ubiquinone metabolic process (GO:0006743)3.45942078
80fusion of sperm to egg plasma membrane (GO:0007342)3.45399916
81retinoic acid receptor signaling pathway (GO:0048384)3.45201875
82regulation of telomerase activity (GO:0051972)3.45005180
83pre-miRNA processing (GO:0031054)3.44724732
84RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.43415934
85tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.43415934
86regulation of mitochondrial translation (GO:0070129)3.42971318
87galactose catabolic process (GO:0019388)3.42071444
88bone trabecula formation (GO:0060346)3.39797744
89negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.39200240
90histone H2A acetylation (GO:0043968)3.38485493
91single strand break repair (GO:0000012)3.36424014
92intestinal epithelial cell development (GO:0060576)3.36376078
93epoxygenase P450 pathway (GO:0019373)3.36152166
94mRNA stabilization (GO:0048255)3.32769925
95RNA stabilization (GO:0043489)3.32769925
96response to pheromone (GO:0019236)3.32387773
97protein deneddylation (GO:0000338)3.28879840
98establishment of viral latency (GO:0019043)3.27048918
99positive regulation of histone deacetylation (GO:0031065)3.26685682
100intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.26549151
101regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.26441868
102transcription from mitochondrial promoter (GO:0006390)3.24371329
103L-serine metabolic process (GO:0006563)3.22387997
104nucleoside transport (GO:0015858)3.21623724
105signal transduction involved in regulation of gene expression (GO:0023019)3.19641978
106DNA methylation involved in gamete generation (GO:0043046)3.19231789
107negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17590485
108spermatid development (GO:0007286)3.16444092
109proline transport (GO:0015824)3.16110456
110pore complex assembly (GO:0046931)3.15559155
111vitamin A metabolic process (GO:0006776)3.15283987
112meiosis I (GO:0007127)3.12986188
113lipopolysaccharide metabolic process (GO:0008653)3.12707946
114ribosome biogenesis (GO:0042254)3.12707783
115icosanoid secretion (GO:0032309)3.11569877
116arachidonic acid secretion (GO:0050482)3.11569877
117mitotic chromosome condensation (GO:0007076)3.10470182
118microtubule depolymerization (GO:0007019)3.08779680
119positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.08324780
120regulation of cellular amino acid metabolic process (GO:0006521)3.07368153
121DNA duplex unwinding (GO:0032508)3.05725391
122regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.05697820
123DNA geometric change (GO:0032392)3.02461809
124cofactor transport (GO:0051181)3.02148783
125omega-hydroxylase P450 pathway (GO:0097267)3.00946923
126maternal placenta development (GO:0001893)3.00005935
127tRNA aminoacylation for protein translation (GO:0006418)2.99117520
128base-excision repair, AP site formation (GO:0006285)2.98951255
129regulation of microtubule-based movement (GO:0060632)2.98233870
130mitochondrial fission (GO:0000266)2.98204478
131pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.98002263
132apoptotic DNA fragmentation (GO:0006309)2.96295652
133trophectodermal cell differentiation (GO:0001829)2.96294848
134negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.94676086
135plasma membrane fusion (GO:0045026)2.93599876
136negative regulation of ligase activity (GO:0051352)2.92883053
137negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.92883053
138pyrimidine nucleotide catabolic process (GO:0006244)2.89337530
139cellular biogenic amine biosynthetic process (GO:0042401)2.88402907
140protein complex biogenesis (GO:0070271)2.88319385
141anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.87506850
142adaptation of signaling pathway (GO:0023058)2.86311758
143microtubule polymerization or depolymerization (GO:0031109)2.83298990
144regulation of mitochondrial fission (GO:0090140)2.83023231
145positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.82123411
146DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.81812100
147resolution of meiotic recombination intermediates (GO:0000712)2.80765489
148type B pancreatic cell proliferation (GO:0044342)2.80695970
149amino acid activation (GO:0043038)2.80441347
150tRNA aminoacylation (GO:0043039)2.80441347
151amine biosynthetic process (GO:0009309)2.77938653
152mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.77664097
153spermatid nucleus differentiation (GO:0007289)2.76472795
154ribosome assembly (GO:0042255)2.76208755
155multicellular organism reproduction (GO:0032504)2.75899597
156peroxisome fission (GO:0016559)2.75166105
157quinone biosynthetic process (GO:1901663)2.74777686
158branched-chain amino acid catabolic process (GO:0009083)2.74344336
159protein targeting to mitochondrion (GO:0006626)2.73576227
160establishment of integrated proviral latency (GO:0075713)2.72694654
161signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.72164336
162intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.72164336
163protein localization to mitochondrion (GO:0070585)2.71764161
164signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.70692154
165signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.70692154
166signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.70692154
167peptidyl-histidine modification (GO:0018202)2.70286892
168chaperone-mediated protein transport (GO:0072321)2.70182800
169intraciliary transport (GO:0042073)2.68525731
170cell-cell recognition (GO:0009988)2.67625629
171pyrimidine nucleobase catabolic process (GO:0006208)2.67544742
172protein-cofactor linkage (GO:0018065)2.66549024
173nonmotile primary cilium assembly (GO:0035058)2.66486872
174signal transduction involved in cell cycle checkpoint (GO:0072395)2.65915402
175establishment of protein localization to mitochondrial membrane (GO:0090151)2.64879247
176peptidyl-arginine omega-N-methylation (GO:0035247)2.64234152
177signal transduction involved in DNA integrity checkpoint (GO:0072401)2.64051485
178signal transduction involved in DNA damage checkpoint (GO:0072422)2.64051485
179ncRNA 3-end processing (GO:0043628)2.63933577
180mitochondrial respiratory chain complex assembly (GO:0033108)2.62625941
181ATP hydrolysis coupled proton transport (GO:0015991)2.61585387
182energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.61585387
183platelet dense granule organization (GO:0060155)2.61354626
184positive regulation of ligase activity (GO:0051351)2.60894051
185regulation of centriole replication (GO:0046599)2.58700686
186dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.58518856
187tRNA methylation (GO:0030488)2.57855946
188C-terminal protein lipidation (GO:0006501)2.57553370
189mannosylation (GO:0097502)2.57530307
190polyketide metabolic process (GO:0030638)11.5219406
191doxorubicin metabolic process (GO:0044598)11.5219406
192daunorubicin metabolic process (GO:0044597)11.5219406

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.75786949
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.56455043
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.56455043
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.56455043
5E2F7_22180533_ChIP-Seq_HELA_Human4.66116803
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.40164650
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.01665787
8* GABP_17652178_ChIP-ChIP_JURKAT_Human3.96689703
9TP63_19390658_ChIP-ChIP_HaCaT_Human3.50282316
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.27365020
11NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.25009757
12THAP11_20581084_ChIP-Seq_MESCs_Mouse3.03845911
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.89717251
14SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.84701353
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.83066841
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.73651286
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.72302970
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.60448396
19SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.58940778
20TCF3_18692474_ChIP-Seq_MESCs_Mouse2.50149597
21DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.48070056
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42647490
23GABP_19822575_ChIP-Seq_HepG2_Human2.39497775
24ZNF274_21170338_ChIP-Seq_K562_Hela2.37065968
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.36793254
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.32646920
27TCF3_18692474_ChIP-Seq_MEFs_Mouse2.30355380
28VDR_23849224_ChIP-Seq_CD4+_Human2.25652496
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.25072772
30DCP1A_22483619_ChIP-Seq_HELA_Human2.21840137
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21097068
32NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.07214679
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.06945138
34FOXM1_23109430_ChIP-Seq_U2OS_Human2.00473305
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.99052002
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.96540138
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95915008
38NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.94014926
39IRF1_19129219_ChIP-ChIP_H3396_Human1.88237430
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82682556
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.82089931
42NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.81038296
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79578049
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.78691559
45EZH2_22144423_ChIP-Seq_EOC_Human1.76717974
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.75000706
47POU5F1_16518401_ChIP-PET_MESCs_Mouse1.69397595
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.69231895
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.68892621
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63471485
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63466738
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63027873
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.62954790
54TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.57530263
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.56419122
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54542781
57* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52861317
58ELK1_19687146_ChIP-ChIP_HELA_Human1.50174720
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.47256235
60MYC_18940864_ChIP-ChIP_HL60_Human1.46758325
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46110208
62E2F1_17053090_ChIP-ChIP_MCF-7_Human1.41929701
63MYC_22102868_ChIP-Seq_BL_Human1.41904606
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41718900
65POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.40017040
66NANOG_18692474_ChIP-Seq_MESCs_Mouse1.38991280
67SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.38604462
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.38316361
69MYC_18555785_ChIP-Seq_MESCs_Mouse1.38100749
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.38047511
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36232598
72XRN2_22483619_ChIP-Seq_HELA_Human1.35529471
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34793230
74PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.31394193
75CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.30695005
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30285798
77ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29543447
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28543246
79MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28456858
80MYC_19079543_ChIP-ChIP_MESCs_Mouse1.27742696
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27650954
82CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27395062
83NANOG_18692474_ChIP-Seq_MEFs_Mouse1.27136889
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26918191
85TFEB_21752829_ChIP-Seq_HELA_Human1.24579315
86NANOG_16518401_ChIP-PET_MESCs_Mouse1.23560848
87TTF2_22483619_ChIP-Seq_HELA_Human1.22590954
88ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22115768
89OCT4_18692474_ChIP-Seq_MEFs_Mouse1.18867763
90SOX2_18692474_ChIP-Seq_MESCs_Mouse1.18110151
91ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16714613
92MYC_18358816_ChIP-ChIP_MESCs_Mouse1.12406571
93* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11863723
94PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10250757
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08009449
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07210373
97CDX2_20551321_ChIP-Seq_CACO-2_Human1.06916396
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06572498
99ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06399874
100EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04814402
101TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04130135
102SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02388798
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00029932
104NANOG_21062744_ChIP-ChIP_HESCs_Human0.99862292
105KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99226222
106NANOG_16153702_ChIP-ChIP_HESCs_Human0.98521552
107SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98173963
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96986635
109SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96878130
110NCOR1_26117541_ChIP-Seq_K562_Human0.96023526
111TP53_22127205_ChIP-Seq_IMR90_Human0.94845648
112CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92961138
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91770647
114CTCF_18555785_ChIP-Seq_MESCs_Mouse0.91513097
115SOX2_16153702_ChIP-ChIP_HESCs_Human0.91247471
116POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91029228
117FOXP1_21924763_ChIP-Seq_HESCs_Human0.89750394
118CREB1_15753290_ChIP-ChIP_HEK293T_Human0.89732998
119KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.87725484
120PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87223712
121ELK1_22589737_ChIP-Seq_MCF10A_Human0.86268114
122TCF7_22412390_ChIP-Seq_EML_Mouse0.85551792
123TBX3_20139965_ChIP-Seq_ESCs_Mouse0.85357023
124DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85107961
125TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.84958347
126ERG_20517297_ChIP-Seq_VCAP_Human0.84914641
127EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84346851
128CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84324485
129POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84192693
130* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84102729
131FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.84101728
132NANOG_20526341_ChIP-Seq_ESCs_Human0.84084682
133TBX3_20139965_ChIP-Seq_MESCs_Mouse0.83948275
134PHF8_20622854_ChIP-Seq_HELA_Human0.83471553
135CTBP1_25329375_ChIP-Seq_LNCAP_Human0.82981740
136FOXP3_21729870_ChIP-Seq_TREG_Human0.80607415
137KAP1_27257070_Chip-Seq_ESCs_Mouse0.80122003
138FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79589516
139KDM2B_26808549_Chip-Seq_SUP-B15_Human0.78683549
140SMC4_20622854_ChIP-Seq_HELA_Human0.78073080
141STAT3_18555785_ChIP-Seq_MESCs_Mouse0.78000115
142* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.77908875
143ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.77532326
144SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75708799
145PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.73798042
146EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.73705283
147SRY_22984422_ChIP-ChIP_TESTIS_Rat0.73403168
148E2F1_18555785_ChIP-Seq_MESCs_Mouse0.73188177
149SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.72740448
150RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.72419002
151YY1_22570637_ChIP-Seq_MALME-3M_Human0.72295941
152IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.71922826
153CBP_20019798_ChIP-Seq_JUKART_Human0.71922826
154ELF1_20517297_ChIP-Seq_JURKAT_Human0.71618399
155CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.71510869
156CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.70909736
157KLF4_18555785_ChIP-Seq_MESCs_Mouse0.70900139
158SCL_19346495_ChIP-Seq_HPC-7_Human0.70878731
159ELK4_26923725_Chip-Seq_MESODERM_Mouse0.69904853
160EGR1_19374776_ChIP-ChIP_THP-1_Human0.69203218
161KDM5A_27292631_Chip-Seq_BREAST_Human0.68860576
162RNF2_27304074_Chip-Seq_NSC_Mouse0.67485347
163EST1_17652178_ChIP-ChIP_JURKAT_Human0.65413674
164SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.65040854
165SPI1_26923725_Chip-Seq_HPCs_Mouse0.63585653
166KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.63513008
167ELK3_25401928_ChIP-Seq_HUVEC_Human0.62461250
168E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.62405852
169P68_20966046_ChIP-Seq_HELA_Human0.62138280

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.60294970
2MP0003011_delayed_dark_adaptation4.53984016
3MP0004264_abnormal_extraembryonic_tissu4.43246201
4MP0002254_reproductive_system_inflammat4.07637279
5MP0003718_maternal_effect4.01229815
6MP0003890_abnormal_embryonic-extraembry3.64514382
7MP0005410_abnormal_fertilization3.52875939
8MP0008058_abnormal_DNA_repair3.40176581
9MP0005394_taste/olfaction_phenotype3.38679128
10MP0005499_abnormal_olfactory_system3.38679128
11MP0004858_abnormal_nervous_system3.37930596
12MP0003122_maternal_imprinting3.35999025
13MP0008057_abnormal_DNA_replication3.19406216
14MP0000372_irregular_coat_pigmentation3.17667742
15MP0005075_abnormal_melanosome_morpholog3.16588787
16MP0002102_abnormal_ear_morphology2.93571052
17MP0002332_abnormal_exercise_endurance2.72917804
18MP0005257_abnormal_intraocular_pressure2.69619661
19MP0008877_abnormal_DNA_methylation2.69181891
20MP0004957_abnormal_blastocyst_morpholog2.68424741
21MP0003121_genomic_imprinting2.66280967
22MP0008260_abnormal_autophagy2.57928688
23MP0004233_abnormal_muscle_weight2.50229539
24MP0002653_abnormal_ependyma_morphology2.49353275
25MP0003186_abnormal_redox_activity2.38158508
26MP0002736_abnormal_nociception_after2.35145955
27MP0000678_abnormal_parathyroid_gland2.35135121
28MP0006035_abnormal_mitochondrial_morpho2.32798042
29MP0001929_abnormal_gametogenesis2.22473274
30MP0003705_abnormal_hypodermis_morpholog2.22014545
31MP0001986_abnormal_taste_sensitivity2.18837616
32MP0001968_abnormal_touch/_nociception2.14584978
33MP0010352_gastrointestinal_tract_polyps2.05911462
34MP0009840_abnormal_foam_cell2.00258259
35MP0003698_abnormal_male_reproductive1.99677523
36MP0003123_paternal_imprinting1.92333171
37MP0005380_embryogenesis_phenotype1.84116339
38MP0001672_abnormal_embryogenesis/_devel1.84116339
39MP0003183_abnormal_peptide_metabolism1.82284386
40MP0001905_abnormal_dopamine_level1.79264746
41MP0001529_abnormal_vocalization1.76097375
42MP0002127_abnormal_cardiovascular_syste1.74829239
43MP0002277_abnormal_respiratory_mucosa1.71801463
44MP0002088_abnormal_embryonic_growth/wei1.70928936
45MP0003938_abnormal_ear_development1.69809849
46MP0003984_embryonic_growth_retardation1.69231373
47MP0008961_abnormal_basal_metabolism1.65355151
48MP0006082_CNS_inflammation1.65316262
49MP0002234_abnormal_pharynx_morphology1.59870854
50MP0002210_abnormal_sex_determination1.59792658
51MP0006036_abnormal_mitochondrial_physio1.51080046
52MP0001293_anophthalmia1.49871648
53MP0003077_abnormal_cell_cycle1.49291081
54MP0002734_abnormal_mechanical_nocicepti1.48745266
55MP0002932_abnormal_joint_morphology1.47777121
56MP0002161_abnormal_fertility/fecundity1.46346874
57MP0000350_abnormal_cell_proliferation1.46232671
58MP0010030_abnormal_orbit_morphology1.42679600
59MP0003136_yellow_coat_color1.42182612
60MP0001849_ear_inflammation1.42076789
61MP0005395_other_phenotype1.40899132
62MP0002396_abnormal_hematopoietic_system1.38609985
63MP0003787_abnormal_imprinting1.38510374
64MP0004147_increased_porphyrin_level1.38496992
65MP0005248_abnormal_Harderian_gland1.32823495
66MP0001984_abnormal_olfaction1.32801025
67MP0005451_abnormal_body_composition1.31893009
68MP0009697_abnormal_copulation1.31817223
69MP0003878_abnormal_ear_physiology1.31777409
70MP0005377_hearing/vestibular/ear_phenot1.31777409
71MP0003111_abnormal_nucleus_morphology1.28195554
72MP0002086_abnormal_extraembryonic_tissu1.28177883
73MP0000015_abnormal_ear_pigmentation1.27419432
74MP0008789_abnormal_olfactory_epithelium1.26757270
75MP0002092_abnormal_eye_morphology1.25874423
76MP0005266_abnormal_metabolism1.25171771
77MP0002085_abnormal_embryonic_tissue1.24674391
78MP0000049_abnormal_middle_ear1.22927197
79MP0000653_abnormal_sex_gland1.22128511
80MP0010094_abnormal_chromosome_stability1.22096661
81MP0001324_abnormal_eye_pigmentation1.20593856
82MP0003646_muscle_fatigue1.20490269
83MP0000762_abnormal_tongue_morphology1.16384353
84MP0004043_abnormal_pH_regulation1.14465150
85MP0005253_abnormal_eye_physiology1.14153163
86MP0005670_abnormal_white_adipose1.13703358
87MP0002735_abnormal_chemical_nociception1.13586680
88MP0005647_abnormal_sex_gland1.10649840
89MP0001145_abnormal_male_reproductive1.10199919
90MP0002114_abnormal_axial_skeleton1.10067848
91MP0002970_abnormal_white_adipose1.07832984
92MP0005551_abnormal_eye_electrophysiolog1.07204549
93MP0003806_abnormal_nucleotide_metabolis1.06483224
94MP0002233_abnormal_nose_morphology1.05155161
95MP0005171_absent_coat_pigmentation1.04185365
96MP0002084_abnormal_developmental_patter1.04139335
97MP0003786_premature_aging1.03215924
98MP0001348_abnormal_lacrimal_gland1.00352434
99MP0001545_abnormal_hematopoietic_system1.00134535
100MP0005397_hematopoietic_system_phenotyp1.00134535
101MP0008995_early_reproductive_senescence0.99255755
102MP0003935_abnormal_craniofacial_develop0.96473317
103MP0000432_abnormal_head_morphology0.96043455
104MP0000428_abnormal_craniofacial_morphol0.95838648
105MP0005423_abnormal_somatic_nervous0.95296863
106MP0006276_abnormal_autonomic_nervous0.93749576
107MP0008770_decreased_survivor_rate0.93575140
108MP0001188_hyperpigmentation0.93199993
109MP0003119_abnormal_digestive_system0.92729834
110MP0000490_abnormal_crypts_of0.92672857
111MP0005408_hypopigmentation0.92512474
112MP0000313_abnormal_cell_death0.91591588
113MP0002132_abnormal_respiratory_system0.91570289
114MP0002229_neurodegeneration0.90643971
115MP0003880_abnormal_central_pattern0.90109438
116MP0003755_abnormal_palate_morphology0.89706902
117MP0003137_abnormal_impulse_conducting0.89660826
118MP0004133_heterotaxia0.88871819
119MP0003950_abnormal_plasma_membrane0.88862306
120MP0004270_analgesia0.88708005
121MP0008007_abnormal_cellular_replicative0.88514646
122MP0003329_amyloid_beta_deposits0.88384860
123MP0003283_abnormal_digestive_organ0.88152270
124MP0001764_abnormal_homeostasis0.87151555
125MP0004197_abnormal_fetal_growth/weight/0.86225720
126MP0001730_embryonic_growth_arrest0.85960052
127MP0005623_abnormal_meninges_morphology0.85498328
128MP0005332_abnormal_amino_acid0.85193670
129MP0003315_abnormal_perineum_morphology0.85097540
130MP0008932_abnormal_embryonic_tissue0.84344366
131MP0005391_vision/eye_phenotype0.83232907
132MP0001697_abnormal_embryo_size0.83166842
133MP0000751_myopathy0.81519977
134MP0002269_muscular_atrophy0.81418999
135MP0005508_abnormal_skeleton_morphology0.79853863
136MP0002177_abnormal_outer_ear0.78870416
137MP0002067_abnormal_sensory_capabilities0.78246799
138MP0002751_abnormal_autonomic_nervous0.78104523
139MP0002925_abnormal_cardiovascular_devel0.77749889
140MP0002080_prenatal_lethality0.77143266
141MP0004381_abnormal_hair_follicle0.76961672
142MP0004145_abnormal_muscle_electrophysio0.76730229
143MP0003656_abnormal_erythrocyte_physiolo0.75687464
144MP0002116_abnormal_craniofacial_bone0.73588338
145MP0000358_abnormal_cell_content/0.71371248
146MP0002733_abnormal_thermal_nociception0.71229328
147MP0000749_muscle_degeneration0.70443787
148MP0001119_abnormal_female_reproductive0.69212408
149MP0003699_abnormal_female_reproductive0.69198245
150MP0003221_abnormal_cardiomyocyte_apopto0.67839181
151MP0001286_abnormal_eye_development0.67144226
152MP0004859_abnormal_synaptic_plasticity0.66366615
153MP0000747_muscle_weakness0.65778349
154MP0006072_abnormal_retinal_apoptosis0.64743187
155MP0002095_abnormal_skin_pigmentation0.64678083
156MP0005023_abnormal_wound_healing0.64471446
157MP0009703_decreased_birth_body0.63915141
158MP0003693_abnormal_embryo_hatching0.63882582
159MP0002877_abnormal_melanocyte_morpholog0.62727005
160MP0002249_abnormal_larynx_morphology0.61025455
161MP0005384_cellular_phenotype0.59576215
162MP0004782_abnormal_surfactant_physiolog0.56982762
163MP0002081_perinatal_lethality0.56965640
164MP0000750_abnormal_muscle_regeneration0.55764538
165MP0005310_abnormal_salivary_gland0.54221318
166MP0002019_abnormal_tumor_incidence0.52849244
167MP0003937_abnormal_limbs/digits/tail_de0.52287066
168MP0009115_abnormal_fat_cell0.52264432
169MP0001270_distended_abdomen0.50707361
170MP0003861_abnormal_nervous_system0.49843557
171MP0005319_abnormal_enzyme/_coenzyme0.49479533

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.53553338
2Hypochromic microcytic anemia (HP:0004840)6.15751388
3Hepatoblastoma (HP:0002884)5.93864237
4Abnormality of the lower motor neuron (HP:0002366)4.99439602
5Multiple enchondromatosis (HP:0005701)4.88615942
6Rib fusion (HP:0000902)4.72611433
7Ependymoma (HP:0002888)4.63715069
8Aplasia/Hypoplasia of the fovea (HP:0008060)4.13189287
9Hypoplasia of the fovea (HP:0007750)4.13189287
10Chromosomal breakage induced by crosslinking agents (HP:0003221)4.04506864
11Nephroblastoma (Wilms tumor) (HP:0002667)3.87890983
12Neoplasm of striated muscle (HP:0009728)3.77631605
13Rhabdomyosarcoma (HP:0002859)3.65361733
14Embryonal renal neoplasm (HP:0011794)3.59447088
15Acute necrotizing encephalopathy (HP:0006965)3.52563948
16Chromsome breakage (HP:0040012)3.49623576
17Hepatocellular necrosis (HP:0001404)3.48758320
18Abnormal mitochondria in muscle tissue (HP:0008316)3.46767601
19Acute encephalopathy (HP:0006846)3.45166680
20Hepatic necrosis (HP:0002605)3.43549171
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.34823646
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.34823646
23Abnormality of the astrocytes (HP:0100707)3.32415604
24Astrocytoma (HP:0009592)3.32415604
25Hyperinsulinemic hypoglycemia (HP:0000825)3.32166140
26Rectovaginal fistula (HP:0000143)3.30226739
27Rectal fistula (HP:0100590)3.30226739
28Bifid tongue (HP:0010297)3.25514534
29Ragged-red muscle fibers (HP:0003200)3.20435698
30Abnormality of the fovea (HP:0000493)3.20340292
31Generalized aminoaciduria (HP:0002909)3.15714917
32Anomalous pulmonary venous return (HP:0010772)3.12878576
33Testicular atrophy (HP:0000029)3.12422946
34Intestinal fistula (HP:0100819)3.06449085
35Cholecystitis (HP:0001082)3.00767188
36Abnormal gallbladder physiology (HP:0012438)3.00767188
37Increased CSF lactate (HP:0002490)3.00406483
38Mitochondrial inheritance (HP:0001427)2.99431815
39Fused cervical vertebrae (HP:0002949)2.95936589
40Progressive macrocephaly (HP:0004481)2.95144682
41Partial duplication of thumb phalanx (HP:0009944)2.93595957
42Amyotrophic lateral sclerosis (HP:0007354)2.92744066
43Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.90147385
44Hypoplastic pelvis (HP:0008839)2.89889106
45Abnormal lung lobation (HP:0002101)2.86238750
46Aplasia/hypoplasia of the humerus (HP:0006507)2.83545814
47Short humerus (HP:0005792)2.82180825
48Vaginal fistula (HP:0004320)2.81765727
49Increased serum lactate (HP:0002151)2.81654501
50Abnormality of the salivary glands (HP:0010286)2.80918410
51Hypoplasia of the capital femoral epiphysis (HP:0003090)2.79498417
52Neonatal respiratory distress (HP:0002643)2.73691870
53Hypokinesia (HP:0002375)2.71931746
54Aplasia/Hypoplasia of the macula (HP:0008059)2.71376644
55Horizontal nystagmus (HP:0000666)2.70213116
56Congenital primary aphakia (HP:0007707)2.66097232
57Male infertility (HP:0003251)2.65052142
58Increased serum pyruvate (HP:0003542)2.65024324
59Hypochromic anemia (HP:0001931)2.64397974
60Gait imbalance (HP:0002141)2.63389015
61Trismus (HP:0000211)2.62218133
62Abnormality of the pulmonary veins (HP:0011718)2.62192556
63Type I transferrin isoform profile (HP:0003642)2.61890484
64Lactic acidosis (HP:0003128)2.61567652
65Meckel diverticulum (HP:0002245)2.60603953
66Abnormal cartilage morphology (HP:0002763)2.57662237
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.57154906
68Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.55050982
69Abnormal protein N-linked glycosylation (HP:0012347)2.55050982
70Abnormal protein glycosylation (HP:0012346)2.55050982
71Abnormal glycosylation (HP:0012345)2.55050982
72Periauricular skin pits (HP:0100277)2.54719169
73Preauricular pit (HP:0004467)2.54719169
74Absent epiphyses (HP:0010577)2.54614673
75Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.54614673
76Abnormal respiratory motile cilium physiology (HP:0012261)2.54560030
77Abnormality of the phalanges of the hallux (HP:0010057)2.54321926
78Nephrogenic diabetes insipidus (HP:0009806)2.53465312
79Partial duplication of the phalanx of hand (HP:0009999)2.52126515
80Preauricular skin tag (HP:0000384)2.51565053
81Cerebral edema (HP:0002181)2.49449918
82Retinal dysplasia (HP:0007973)2.46477218
83Rhinitis (HP:0012384)2.46355876
84Pendular nystagmus (HP:0012043)2.43850609
85Abnormality of glycolysis (HP:0004366)2.43786954
86Abnormal ciliary motility (HP:0012262)2.43387374
87Abnormality of the ileum (HP:0001549)2.42358982
88Prolonged neonatal jaundice (HP:0006579)2.42131261
89Impulsivity (HP:0100710)2.42099224
90Reduced antithrombin III activity (HP:0001976)2.42071428
91Glioma (HP:0009733)2.41410190
92Shawl scrotum (HP:0000049)2.40518663
93Hyperventilation (HP:0002883)2.39911613
94Generalized hypotonia (HP:0001290)2.39625044
95Aplasia/Hypoplasia affecting the retina (HP:0008061)2.37788010
96High anterior hairline (HP:0009890)2.37724853
97Rough bone trabeculation (HP:0100670)2.32843156
98Hand muscle atrophy (HP:0009130)2.32160857
99Severe visual impairment (HP:0001141)2.31747694
100Supernumerary spleens (HP:0009799)2.31176176
101Tongue fasciculations (HP:0001308)2.31136306
102Medial flaring of the eyebrow (HP:0010747)2.25335311
103Exercise intolerance (HP:0003546)2.25214063
104Nasolacrimal duct obstruction (HP:0000579)2.24989680
105Abnormality of chromosome segregation (HP:0002916)2.24305763
106Emotional lability (HP:0000712)2.24094783
107CNS demyelination (HP:0007305)2.23787763
108Type 2 muscle fiber atrophy (HP:0003554)2.23565388
109Skin tags (HP:0010609)2.22155300
110Large earlobe (HP:0009748)2.20672845
111Abnormality of the distal phalanx of the thumb (HP:0009617)2.19903705
112Aplasia/Hypoplasia of the sternum (HP:0006714)2.18566376
113Redundant skin (HP:0001582)2.17728173
114Neoplasm of the heart (HP:0100544)2.17276971
115Malignant neoplasm of the central nervous system (HP:0100836)2.17002200
116Upper limb muscle weakness (HP:0003484)2.15765086
117Upper motor neuron abnormality (HP:0002127)2.14271855
118Abnormality of small intestinal villus morphology (HP:0011472)2.13723860
119Villous atrophy (HP:0011473)2.13723860
120Short 5th finger (HP:0009237)2.13429087
121Progressive inability to walk (HP:0002505)2.12681124
122Opisthotonus (HP:0002179)2.11894523
123Aplasia of the musculature (HP:0100854)2.11823572
124Delayed gross motor development (HP:0002194)2.11703786
125Microretrognathia (HP:0000308)2.11139953
126Tetraplegia (HP:0002445)2.10840955
127Progressive muscle weakness (HP:0003323)2.10585153
128Exercise-induced muscle cramps (HP:0003710)2.10581229
129Hypopigmentation of the fundus (HP:0007894)2.10342627
130Cheilitis (HP:0100825)2.09521350
131Diminished movement (HP:0002374)2.09468619
132Abnormality of the pubic bones (HP:0003172)2.08805224
133Sclerocornea (HP:0000647)2.08353883
134Muscle fibrillation (HP:0010546)2.07537408
135Respiratory failure (HP:0002878)2.06898977
136Vaginal atresia (HP:0000148)2.06759887
137Renal Fanconi syndrome (HP:0001994)2.06577103
138Facial cleft (HP:0002006)2.04906330
139Aplasia/Hypoplasia of the sacrum (HP:0008517)2.04644185
140Degeneration of anterior horn cells (HP:0002398)2.03683730
141Abnormality of the anterior horn cell (HP:0006802)2.03683730
142Muscle fiber atrophy (HP:0100295)2.03645421
143Abnormality of the musculature of the hand (HP:0001421)2.03300010
144Small intestinal stenosis (HP:0012848)2.03069059
145Duodenal stenosis (HP:0100867)2.03069059
146Sensory axonal neuropathy (HP:0003390)2.02788389
147Genital tract atresia (HP:0001827)2.02639679
148Abnormality of abdominal situs (HP:0011620)2.01559049
149Abdominal situs inversus (HP:0003363)2.01559049
150Renal duplication (HP:0000075)2.00517217
151Abnormal gallbladder morphology (HP:0012437)2.00453982
152Absent/shortened dynein arms (HP:0200106)1.99711249
153Dynein arm defect of respiratory motile cilia (HP:0012255)1.99711249
154Cholelithiasis (HP:0001081)1.99521422
155Abnormal respiratory epithelium morphology (HP:0012253)1.99455050
156Abnormal respiratory motile cilium morphology (HP:0005938)1.99455050
157Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.98489780
158Skin pits (HP:0100276)1.98348968
159Inability to walk (HP:0002540)1.98051619
160Progressive microcephaly (HP:0000253)1.97852951
161Abnormal trabecular bone morphology (HP:0100671)1.96773277
162Poor suck (HP:0002033)1.96386577
163Cerebral hypomyelination (HP:0006808)1.96028097
164Increased connective tissue (HP:0009025)1.95993278
165Postnatal microcephaly (HP:0005484)1.95472025
166Pseudobulbar signs (HP:0002200)1.94749097
167Combined immunodeficiency (HP:0005387)1.94611222
168Nasal polyposis (HP:0100582)1.93448090
169Diastasis recti (HP:0001540)1.92134292
170Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91828120
171Delusions (HP:0000746)1.91136483
172Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.90509577
173Muscular hypotonia of the trunk (HP:0008936)1.90343209
174X-linked dominant inheritance (HP:0001423)1.90056330
175Medulloblastoma (HP:0002885)1.89755947
176Abnormality of the intrinsic pathway (HP:0010989)1.89742899
177Glossoptosis (HP:0000162)1.89449216
178Retinal atrophy (HP:0001105)1.89048671
179Amniotic constriction ring (HP:0009775)1.88722542
180Abnormality of placental membranes (HP:0011409)1.88722542
181Embryonal neoplasm (HP:0002898)1.88623390
182Atrophy/Degeneration involving motor neurons (HP:0007373)1.87937654
183CNS hypomyelination (HP:0003429)1.87823320
184Progressive external ophthalmoplegia (HP:0000590)1.87238315
185Supernumerary nipples (HP:0002558)1.86154131
186Poor coordination (HP:0002370)1.83078063
187Aplastic anemia (HP:0001915)1.82961110
188Progressive neurologic deterioration (HP:0002344)1.77970301

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.49337898
2GRK55.58433196
3ERN14.57401718
4GRK64.47052428
5TESK13.76947030
6TRIM283.57032180
7ADRBK23.56458969
8PDK23.54105889
9BCKDK3.46740675
10PLK43.42947192
11GRK13.36055714
12LIMK12.87950417
13CSF1R2.79898655
14TTK2.60203339
15MUSK2.56712744
16TYRO32.52616793
17TGFBR22.49250056
18GRK72.39709869
19MAPK72.32899541
20PLK22.26109749
21STK102.19141006
22MOS2.17957218
23VRK22.10604505
24MATK2.04196498
25PBK2.01889275
26PIM22.00246063
27MAP4K21.93867011
28WNK11.92691136
29CSNK1G31.81706222
30AKT31.73474973
31ARAF1.61158798
32NME11.59099169
33CAMK41.57690125
34SRPK11.55563872
35CDK71.54998072
36NTRK11.47955449
37STK161.47699258
38CSNK1G11.42733662
39PRKG21.41621584
40ERBB31.39045351
41CSNK1A1L1.38337021
42CSNK1G21.34934587
43MAP3K41.33423066
44ZAK1.32787036
45MARK21.31018950
46DYRK31.25583326
47MAP2K71.25376827
48MAPK131.23692385
49CHEK21.19580624
50BRAF1.16078520
51HIPK21.16022777
52VRK11.15979305
53PLK31.15816967
54PAK41.14342220
55IRAK31.13187202
56TSSK61.11741520
57RAF11.11099344
58EPHA21.10607596
59ADRBK11.10537618
60PLK11.10311674
61MAP2K41.08086579
62FGFR31.07808274
63TLK11.04865111
64MAP3K101.03025283
65NME20.95790775
66MST40.95527029
67BCR0.88674586
68MST1R0.84973616
69MAP3K70.82463311
70BRSK10.82433686
71RPS6KA50.80568175
72LATS20.80149111
73CHEK10.78687900
74INSRR0.78262097
75MARK10.78029734
76ABL20.77533174
77EPHA40.76723230
78WEE10.76603748
79AKT20.74128448
80WNK30.73413139
81FER0.71601101
82NEK60.71071770
83ALK0.69440372
84NUAK10.69425114
85CDK140.69063596
86CASK0.68085507
87MAP2K60.67387997
88CAMK2G0.66518477
89CSK0.66018530
90EIF2AK20.65741173
91PRKCE0.64545058
92CDK190.61498902
93DAPK30.60345406
94MAPK120.59284288
95MAP3K80.56075230
96NEK20.55686626
97MTOR0.53703657
98TIE10.53229241
99DAPK10.52194652
100EIF2AK10.51572792
101CDC70.46720887
102CLK10.45359617
103ILK0.44756947
104PRKD30.44396200
105CDK20.43786431
106AURKA0.43378302
107CAMK2B0.42461280
108PHKG10.41831680
109PHKG20.41831680
110PTK2B0.41377655
111CAMK2D0.40746354
112PRPF4B0.40074010
113PKN10.39513879
114RPS6KB20.38646904
115MAPKAPK50.38223683
116ITK0.38183226
117ERBB40.37760326
118IGF1R0.37544939
119MAP3K90.37512871
120CDK80.37164677
121CAMK2A0.37051970
122WNK40.36122622
123ATM0.35800620
124CSNK2A10.35331258
125PTK20.35241045
126CDK40.34594355
127TAOK20.33999698
128BMPR1B0.33504674
129PRKD20.33341708
130PRKCD0.32816148
131PDGFRA0.31953047
132NEK10.31442228
133PRKCI0.30476787
134AURKB0.29337514
135RIPK10.28695981
136IKBKB0.26829364
137TNK20.26588928
138MAPKAPK30.25237601
139TAOK10.25107066
140CDK10.24887450
141MAPK100.24863580
142PRKAA10.24286511
143CSNK1E0.24210693
144INSR0.24185371
145PAK10.23722661
146BUB10.22869449
147BMX0.22222234
148ERBB20.20900974
149MAPK10.20661877
150PAK60.20353684
151STK380.20192940
152GSK3B0.19574724
153MAPK140.19174828
154CHUK0.18150472
155FLT30.16824477
156DYRK1A0.16440102
157PRKACG0.15525434
158ICK0.13289359
159SIK10.13174765
160PRKCG0.13066110
161TESK20.13059360
162PRKACB0.11136012
163CDK150.10808350
164AKT10.10307272
165PRKCH0.09762255
166CDK180.09209925
167ATR0.09000909
168PAK30.08911740
169CDK11A0.08495968
170RPS6KA30.07937038
171DYRK20.07871948
172MAPK40.07606353

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.50509625
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006036.44248690
3Fructose and mannose metabolism_Homo sapiens_hsa000514.09115249
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.95827924
5Proteasome_Homo sapiens_hsa030503.39259650
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.28608976
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.80873359
8Galactose metabolism_Homo sapiens_hsa000522.76433542
9Oxidative phosphorylation_Homo sapiens_hsa001902.68598500
10Arachidonic acid metabolism_Homo sapiens_hsa005902.46023960
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.28261325
12Parkinsons disease_Homo sapiens_hsa050122.24893110
13Steroid biosynthesis_Homo sapiens_hsa001002.14376592
14Huntingtons disease_Homo sapiens_hsa050162.07834716
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.03754678
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.99781902
17RNA polymerase_Homo sapiens_hsa030201.99239300
18Fatty acid elongation_Homo sapiens_hsa000621.92261228
19Linoleic acid metabolism_Homo sapiens_hsa005911.90353638
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.88439428
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.88329942
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.85843677
23Butanoate metabolism_Homo sapiens_hsa006501.75849648
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73417437
25Protein export_Homo sapiens_hsa030601.72806748
26Pyrimidine metabolism_Homo sapiens_hsa002401.71701039
27RNA transport_Homo sapiens_hsa030131.69173278
28Thyroid cancer_Homo sapiens_hsa052161.68047278
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67863372
30One carbon pool by folate_Homo sapiens_hsa006701.67804223
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.63861921
32mTOR signaling pathway_Homo sapiens_hsa041501.63472777
33Fanconi anemia pathway_Homo sapiens_hsa034601.62564881
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55391234
35Glutathione metabolism_Homo sapiens_hsa004801.54242242
36Fatty acid metabolism_Homo sapiens_hsa012121.53664940
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51366028
38Nucleotide excision repair_Homo sapiens_hsa034201.49746621
39Non-homologous end-joining_Homo sapiens_hsa034501.45187947
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43076788
41Collecting duct acid secretion_Homo sapiens_hsa049661.42861132
42mRNA surveillance pathway_Homo sapiens_hsa030151.42128992
43Propanoate metabolism_Homo sapiens_hsa006401.38902717
44Alzheimers disease_Homo sapiens_hsa050101.37203214
45Pyruvate metabolism_Homo sapiens_hsa006201.31734389
46Cell cycle_Homo sapiens_hsa041101.30623374
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25144778
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.21336139
49Purine metabolism_Homo sapiens_hsa002301.17549605
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.15654225
51Ovarian steroidogenesis_Homo sapiens_hsa049131.14453231
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13906246
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12750374
54Vibrio cholerae infection_Homo sapiens_hsa051101.12008284
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11941477
56RNA degradation_Homo sapiens_hsa030181.10274888
57DNA replication_Homo sapiens_hsa030301.05946069
58Homologous recombination_Homo sapiens_hsa034401.05564633
59Cardiac muscle contraction_Homo sapiens_hsa042600.99106031
60Inositol phosphate metabolism_Homo sapiens_hsa005620.98637633
61Mismatch repair_Homo sapiens_hsa034300.97722254
62N-Glycan biosynthesis_Homo sapiens_hsa005100.96581831
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94509894
64Chemical carcinogenesis_Homo sapiens_hsa052040.93544092
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92942499
66Metabolic pathways_Homo sapiens_hsa011000.92691591
67Other glycan degradation_Homo sapiens_hsa005110.92362678
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92260355
69Synaptic vesicle cycle_Homo sapiens_hsa047210.91336931
70Fatty acid biosynthesis_Homo sapiens_hsa000610.91215366
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90264391
72Peroxisome_Homo sapiens_hsa041460.88599387
73Arginine and proline metabolism_Homo sapiens_hsa003300.87414932
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84917941
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82957664
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.82839796
77Pentose phosphate pathway_Homo sapiens_hsa000300.80856850
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.80787857
79Fatty acid degradation_Homo sapiens_hsa000710.78429290
80Acute myeloid leukemia_Homo sapiens_hsa052210.77134984
81Tryptophan metabolism_Homo sapiens_hsa003800.76705702
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76530545
83Base excision repair_Homo sapiens_hsa034100.76079281
84Oocyte meiosis_Homo sapiens_hsa041140.73029604
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72711684
86Phenylalanine metabolism_Homo sapiens_hsa003600.72681065
87p53 signaling pathway_Homo sapiens_hsa041150.71150712
88Pathways in cancer_Homo sapiens_hsa052000.69105596
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68580559
90Sulfur metabolism_Homo sapiens_hsa009200.67586299
91Basal cell carcinoma_Homo sapiens_hsa052170.67456372
92Choline metabolism in cancer_Homo sapiens_hsa052310.66783014
93MicroRNAs in cancer_Homo sapiens_hsa052060.65175848
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64756852
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63426922
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61604077
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61591690
98Non-small cell lung cancer_Homo sapiens_hsa052230.61459064
99Folate biosynthesis_Homo sapiens_hsa007900.61034456
100Bladder cancer_Homo sapiens_hsa052190.60046947
101Herpes simplex infection_Homo sapiens_hsa051680.59986712
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58956274
103Hedgehog signaling pathway_Homo sapiens_hsa043400.58748239
104Rap1 signaling pathway_Homo sapiens_hsa040150.58489830
105Primary immunodeficiency_Homo sapiens_hsa053400.58118078
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.56604917
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56125374
108Spliceosome_Homo sapiens_hsa030400.54873009
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53484826
110Biosynthesis of amino acids_Homo sapiens_hsa012300.53120580
111Basal transcription factors_Homo sapiens_hsa030220.51592281
112Regulation of autophagy_Homo sapiens_hsa041400.51111724
113Notch signaling pathway_Homo sapiens_hsa043300.49926166
114Caffeine metabolism_Homo sapiens_hsa002320.49835239
115Pancreatic cancer_Homo sapiens_hsa052120.48323576
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47745168
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47281870
118Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45802827
119Carbon metabolism_Homo sapiens_hsa012000.45451484
120Sulfur relay system_Homo sapiens_hsa041220.45249366
121Tyrosine metabolism_Homo sapiens_hsa003500.45210398
122Apoptosis_Homo sapiens_hsa042100.44073508
123Selenocompound metabolism_Homo sapiens_hsa004500.43354098
124Ether lipid metabolism_Homo sapiens_hsa005650.43261702
125Taste transduction_Homo sapiens_hsa047420.42585240
126Hippo signaling pathway_Homo sapiens_hsa043900.39693248
127Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39283423
128Colorectal cancer_Homo sapiens_hsa052100.38624893
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.38113910
130beta-Alanine metabolism_Homo sapiens_hsa004100.37473083
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36997095
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36793272
133Phototransduction_Homo sapiens_hsa047440.35920552
134Complement and coagulation cascades_Homo sapiens_hsa046100.35736063
135Sphingolipid metabolism_Homo sapiens_hsa006000.35199885
136Wnt signaling pathway_Homo sapiens_hsa043100.34002646
137HTLV-I infection_Homo sapiens_hsa051660.33473078
138NF-kappa B signaling pathway_Homo sapiens_hsa040640.33416713
139Alcoholism_Homo sapiens_hsa050340.33281748
140Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32961186
141African trypanosomiasis_Homo sapiens_hsa051430.31042307
142Fat digestion and absorption_Homo sapiens_hsa049750.30838250
143AMPK signaling pathway_Homo sapiens_hsa041520.29194175
144T cell receptor signaling pathway_Homo sapiens_hsa046600.28664011
145Adherens junction_Homo sapiens_hsa045200.28578024
146Intestinal immune network for IgA production_Homo sapiens_hsa046720.27818590
147Serotonergic synapse_Homo sapiens_hsa047260.27291119
148Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26601749
149Ras signaling pathway_Homo sapiens_hsa040140.25542447
150Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25477495
151Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24022056
152Olfactory transduction_Homo sapiens_hsa047400.23842853
153VEGF signaling pathway_Homo sapiens_hsa043700.23799777
154Lysosome_Homo sapiens_hsa041420.22020735
155Lysine degradation_Homo sapiens_hsa003100.20644584
156Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19477502
157Viral carcinogenesis_Homo sapiens_hsa052030.19075831
158Proteoglycans in cancer_Homo sapiens_hsa052050.16624067
159GnRH signaling pathway_Homo sapiens_hsa049120.16601355
160Cysteine and methionine metabolism_Homo sapiens_hsa002700.16051750
161Vascular smooth muscle contraction_Homo sapiens_hsa042700.16016256
162Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.15654921

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