WDR27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with multiple WD repeats. Proteins with these repeats may form scaffolds for protein-protein interaction and play key roles in cell signalling. Alternative splicing results in multiple transcript variants, but the full-length structure of some of these variants cannot be determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.88886092
2multicellular organism reproduction (GO:0032504)9.59208049
3cell wall macromolecule metabolic process (GO:0044036)9.47939104
4cell wall macromolecule catabolic process (GO:0016998)9.47939104
5plasma membrane fusion (GO:0045026)9.13417947
6acrosome reaction (GO:0007340)9.10014917
7sperm-egg recognition (GO:0035036)9.02706894
8epithelial cilium movement (GO:0003351)8.96866098
9motile cilium assembly (GO:0044458)8.88330700
10acrosome assembly (GO:0001675)8.72328513
11piRNA metabolic process (GO:0034587)8.49065267
12cilium movement (GO:0003341)8.18931451
13cell-cell recognition (GO:0009988)8.04262135
14reproduction (GO:0000003)7.86584184
15binding of sperm to zona pellucida (GO:0007339)7.85814242
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.76735449
17male meiosis (GO:0007140)7.74165457
18spermatid development (GO:0007286)7.56217295
19synaptonemal complex organization (GO:0070193)7.13723167
20synaptonemal complex assembly (GO:0007130)6.82945429
21single fertilization (GO:0007338)6.32722299
22regulation of cilium movement (GO:0003352)6.19610966
23sperm capacitation (GO:0048240)6.08592421
24negative regulation of inclusion body assembly (GO:0090084)5.87026987
25ventricular system development (GO:0021591)5.61495674
26fertilization (GO:0009566)5.41476407
27DNA methylation involved in gamete generation (GO:0043046)5.30581032
28calcium ion-dependent exocytosis (GO:0017156)4.94492556
29spermatogenesis (GO:0007283)4.93869224
30male gamete generation (GO:0048232)4.91474471
31male meiosis I (GO:0007141)4.75198123
32microtubule severing (GO:0051013)4.72954159
33gamete generation (GO:0007276)4.53000609
34left/right pattern formation (GO:0060972)4.49094916
35cell recognition (GO:0008037)4.40799875
36germ cell development (GO:0007281)4.36460641
37cellular process involved in reproduction in multicellular organism (GO:0022412)4.35735980
38regulation of inclusion body assembly (GO:0090083)4.35630874
39protein localization to cilium (GO:0061512)4.29728053
40chromosome organization involved in meiosis (GO:0070192)4.28356366
41protein polyglutamylation (GO:0018095)4.16967777
42regulation of microtubule-based movement (GO:0060632)4.07681372
43meiosis I (GO:0007127)4.07212162
44meiotic nuclear division (GO:0007126)4.06321251
45axoneme assembly (GO:0035082)3.86496163
46organic cation transport (GO:0015695)3.85158763
47microtubule depolymerization (GO:0007019)3.80756326
48negative regulation of organelle assembly (GO:1902116)3.69931924
49meiotic cell cycle (GO:0051321)3.54011599
50multicellular organismal reproductive process (GO:0048609)3.51195170
51nuclear pore complex assembly (GO:0051292)3.41455228
52spermatid nucleus differentiation (GO:0007289)3.41247055
53genitalia morphogenesis (GO:0035112)3.40825548
54pre-miRNA processing (GO:0031054)3.40100936
55microtubule-based movement (GO:0007018)3.37716217
56embryonic retina morphogenesis in camera-type eye (GO:0060059)3.36011849
57intraciliary transport (GO:0042073)3.31358492
58histone H3-K9 demethylation (GO:0033169)3.30460624
59histone H3-K36 demethylation (GO:0070544)3.23623677
60paraxial mesoderm development (GO:0048339)3.22595713
61cilium organization (GO:0044782)3.21220584
62cilium morphogenesis (GO:0060271)3.20681678
63cilium assembly (GO:0042384)3.08454141
64neuronal stem cell maintenance (GO:0097150)3.06550521
65GTP biosynthetic process (GO:0006183)3.05296441
66histone H3-K9 methylation (GO:0051567)3.02737053
67cellular component assembly involved in morphogenesis (GO:0010927)2.97108110
68nucleoside diphosphate phosphorylation (GO:0006165)2.96540533
69nuclear pore organization (GO:0006999)2.94455102
70amino-acid betaine transport (GO:0015838)2.93686616
71carnitine transport (GO:0015879)2.93686616
72carnitine transmembrane transport (GO:1902603)2.90594650
73peptidyl-glutamic acid modification (GO:0018200)2.88049398
74glycerol ether metabolic process (GO:0006662)2.87635676
75calcium ion import (GO:0070509)2.83337657
76multicellular organismal development (GO:0007275)2.82822659
77seminiferous tubule development (GO:0072520)2.82770727
78monoubiquitinated protein deubiquitination (GO:0035520)2.82050717
79alditol metabolic process (GO:0019400)2.81159842
80regulation of centriole replication (GO:0046599)2.80860301
81positive regulation of dendritic spine morphogenesis (GO:0061003)2.79843632
82histone lysine demethylation (GO:0070076)2.75530247
83lung epithelium development (GO:0060428)2.74642028
84left/right axis specification (GO:0070986)2.73847821
85negative regulation of histone methylation (GO:0031061)2.73733974
86microtubule polymerization or depolymerization (GO:0031109)2.73437052
87central nervous system myelination (GO:0022010)2.73203392
88axon ensheathment in central nervous system (GO:0032291)2.73203392
89positive regulation of smoothened signaling pathway (GO:0045880)2.72960110
90regulation of histone H3-K27 methylation (GO:0061085)2.72581420
91glycerol metabolic process (GO:0006071)2.72020827
92regulation of centrosome duplication (GO:0010824)2.69361777
93nephron tubule morphogenesis (GO:0072078)2.68674499
94nephron epithelium morphogenesis (GO:0072088)2.68674499
95nonmotile primary cilium assembly (GO:0035058)2.65557492
96ether metabolic process (GO:0018904)2.65010581
97histone demethylation (GO:0016577)2.62565657
98embryonic foregut morphogenesis (GO:0048617)2.62165471
99DNA damage induced protein phosphorylation (GO:0006975)2.62108163
100regulation of meiosis I (GO:0060631)2.60430168
101UTP biosynthetic process (GO:0006228)2.59396185
102appendage development (GO:0048736)2.57954460
103protein K11-linked deubiquitination (GO:0035871)2.57477334
104chaperone-mediated protein complex assembly (GO:0051131)2.57434307
105convergent extension (GO:0060026)2.57221587
106protein-DNA complex disassembly (GO:0032986)2.56746084
107nucleosome disassembly (GO:0006337)2.56746084
108meiotic chromosome segregation (GO:0045132)2.55785889
109peptidyl-lysine dimethylation (GO:0018027)2.55669888
110polyol catabolic process (GO:0046174)2.55259018
111stress granule assembly (GO:0034063)2.55048722
112centriole assembly (GO:0098534)2.54943014
113head development (GO:0060322)2.53935275
114gene silencing by RNA (GO:0031047)2.53206058
115gastrulation with mouth forming second (GO:0001702)2.53132932
116membrane depolarization during action potential (GO:0086010)2.53126440
117establishment of planar polarity (GO:0001736)2.52926295
118establishment of tissue polarity (GO:0007164)2.52926295
119establishment of apical/basal cell polarity (GO:0035089)2.52130215
120response to methylmercury (GO:0051597)2.51839870
121negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.49100525
122positive regulation of dendrite morphogenesis (GO:0050775)2.48787779
123regulation of spindle checkpoint (GO:0090231)2.47902446
124cranial nerve morphogenesis (GO:0021602)2.45903976
125camera-type eye morphogenesis (GO:0048593)2.44979138
126regulation of non-canonical Wnt signaling pathway (GO:2000050)2.40338725
127dorsal/ventral axis specification (GO:0009950)2.39816383
128regulation of gene silencing by RNA (GO:0060966)2.39755366
129regulation of posttranscriptional gene silencing (GO:0060147)2.39755366
130regulation of gene silencing by miRNA (GO:0060964)2.39755366
131planar cell polarity pathway involved in neural tube closure (GO:0090179)2.39138706
132histone lysine methylation (GO:0034968)2.38529719
133histone H3-K4 trimethylation (GO:0080182)2.38303387
134vitamin transmembrane transport (GO:0035461)2.38020385
135protein demethylation (GO:0006482)2.37391370
136protein dealkylation (GO:0008214)2.37391370
137histone H3-K9 modification (GO:0061647)2.37037935
138single strand break repair (GO:0000012)2.36888479
139smoothened signaling pathway (GO:0007224)2.35800211
140UTP metabolic process (GO:0046051)2.35689789
141regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.34758608
142establishment or maintenance of monopolar cell polarity (GO:0061339)2.34491038
143establishment of monopolar cell polarity (GO:0061162)2.34491038
144regulation of protein polyubiquitination (GO:1902914)2.33001842
145spinal cord development (GO:0021510)2.32771551
146regulation of smoothened signaling pathway (GO:0008589)2.31924984
147regulation of histone H3-K9 methylation (GO:0051570)2.31550379
148coronary vasculature morphogenesis (GO:0060977)2.31058488
149regulation of centrosome cycle (GO:0046605)2.30798643
150mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.30432129
151lactate metabolic process (GO:0006089)2.30363720
152cellular response to cholesterol (GO:0071397)2.29961189
153centriole replication (GO:0007099)2.29941452
154negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.29700306
155negative regulation of translation, ncRNA-mediated (GO:0040033)2.29700306
156regulation of translation, ncRNA-mediated (GO:0045974)2.29700306
157lateral sprouting from an epithelium (GO:0060601)2.29314168
158body morphogenesis (GO:0010171)2.29213417
159DNA synthesis involved in DNA repair (GO:0000731)2.28573474
160peptidyl-lysine methylation (GO:0018022)2.28515580
161heterochromatin organization (GO:0070828)2.26906427
162cell migration in hindbrain (GO:0021535)2.26751862
163intra-S DNA damage checkpoint (GO:0031573)2.25934008
164positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.25374388
165mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.25374388
166neural tube development (GO:0021915)2.24350068
167establishment of nucleus localization (GO:0040023)2.23006374
168meiotic cell cycle process (GO:1903046)2.20367482
169negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.19185816
170chromosome condensation (GO:0030261)2.18157325
171microtubule bundle formation (GO:0001578)2.15368699
172long-chain fatty acid biosynthetic process (GO:0042759)2.14850138
173limb development (GO:0060173)2.14171520
174cilium or flagellum-dependent cell motility (GO:0001539)13.9181382
175fusion of sperm to egg plasma membrane (GO:0007342)11.8178979
176axonemal dynein complex assembly (GO:0070286)10.3151321

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.83454948
2RBPJ_22232070_ChIP-Seq_NCS_Mouse5.67568336
3EZH2_22144423_ChIP-Seq_EOC_Human5.00803323
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.26714534
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.41105710
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.01901471
7E2F7_22180533_ChIP-Seq_HELA_Human2.60892816
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.57050692
9ZNF274_21170338_ChIP-Seq_K562_Hela2.35198862
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.24845634
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.23190949
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17537237
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.17515382
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.14872822
15FUS_26573619_Chip-Seq_HEK293_Human2.11693419
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.07579779
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.04479436
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98880508
19VDR_22108803_ChIP-Seq_LS180_Human1.97432439
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.96779303
21AR_21572438_ChIP-Seq_LNCaP_Human1.90434886
22REST_21632747_ChIP-Seq_MESCs_Mouse1.79602359
23IGF1R_20145208_ChIP-Seq_DFB_Human1.78215974
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69407100
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67807366
26ELK4_26923725_Chip-Seq_MESODERM_Mouse1.66888635
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.66219797
28EWS_26573619_Chip-Seq_HEK293_Human1.65647002
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65486490
30GATA1_26923725_Chip-Seq_HPCs_Mouse1.64266980
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61849504
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60876384
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.58830355
34KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.56712196
35TAL1_26923725_Chip-Seq_HPCs_Mouse1.51074706
36FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.50153033
37TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48942699
38TP53_16413492_ChIP-PET_HCT116_Human1.48904782
39MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.48555065
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46242834
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42093300
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41194848
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41194848
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40912620
45KDM2B_26808549_Chip-Seq_REH_Human1.39987593
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39975502
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39575980
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.37873999
49TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36851878
50ISL1_27105846_Chip-Seq_CPCs_Mouse1.36410140
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.36140482
52CTNNB1_20460455_ChIP-Seq_HCT116_Human1.35451995
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.35391853
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.35008603
55* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34943943
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34523182
57TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34517216
58GBX2_23144817_ChIP-Seq_PC3_Human1.33668904
59TAF15_26573619_Chip-Seq_HEK293_Human1.33146709
60RNF2_27304074_Chip-Seq_NSC_Mouse1.32761803
61EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31921917
62STAT1_17558387_ChIP-Seq_HELA_Human1.30806009
63TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.29871581
64HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28280614
65FOXA2_19822575_ChIP-Seq_HepG2_Human1.26576786
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25609317
67IRF1_19129219_ChIP-ChIP_H3396_Human1.25192639
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25003051
69KAP1_22055183_ChIP-Seq_ESCs_Mouse1.23773230
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.22574908
71AR_19668381_ChIP-Seq_PC3_Human1.22117060
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22081812
73GF1_26923725_Chip-Seq_HPCs_Mouse1.19920665
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18124834
75DROSHA_22980978_ChIP-Seq_HELA_Human1.17339240
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17328226
77ER_23166858_ChIP-Seq_MCF-7_Human1.16978611
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.16563140
79CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16386169
80TCF4_18268006_ChIP-ChIP_LS174T_Human1.15799613
81GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.14978689
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14523356
83CBP_20019798_ChIP-Seq_JUKART_Human1.14523356
84WDR5_24793694_ChIP-Seq_LNCAP_Human1.14413712
85E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14356168
86SOX9_26525672_Chip-Seq_HEART_Mouse1.14253699
87CMYC_18555785_Chip-Seq_ESCs_Mouse1.13629136
88TCF4_23295773_ChIP-Seq_U87_Human1.13397951
89P53_22387025_ChIP-Seq_ESCs_Mouse1.13341693
90EED_16625203_ChIP-ChIP_MESCs_Mouse1.12839459
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12693033
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12560728
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11343760
94* RUNX2_22187159_ChIP-Seq_PCA_Human1.10666512
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10255506
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.10197564
97E2F1_21310950_ChIP-Seq_MCF-7_Human1.10022428
98SMAD4_21799915_ChIP-Seq_A2780_Human1.09959179
99YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08836933
100PIAS1_25552417_ChIP-Seq_VCAP_Human1.08785395
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08262430
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08062480
103E2F1_17053090_ChIP-ChIP_MCF-7_Human1.07949186
104MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07897584
105P300_18555785_Chip-Seq_ESCs_Mouse1.07794963
106EZH2_27304074_Chip-Seq_ESCs_Mouse1.07698559
107FLI1_21867929_ChIP-Seq_TH2_Mouse1.07658682
108DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07148274
109SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06330121
110EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06002094
111WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05970738
112PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05943524
113TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05202582
114NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04800695
115OCT4_18555785_Chip-Seq_ESCs_Mouse1.04476087
116KLF4_18555785_Chip-Seq_ESCs_Mouse1.04456884
117PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04396072
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03681338
119* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02667110
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02622324
121E2F1_18555785_Chip-Seq_ESCs_Mouse1.01089452
122RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00975973
123STAT3_18555785_Chip-Seq_ESCs_Mouse1.00620313
124ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99516670
125SMAD3_21741376_ChIP-Seq_EPCs_Human0.99386390
126OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99022772
127TBL1_22424771_ChIP-Seq_293T_Human0.98678208
128SMAD3_21741376_ChIP-Seq_ESCs_Human0.98669593
129* STAT3_23295773_ChIP-Seq_U87_Human0.98494012
130TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98258806
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98152017
132PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98038498
133CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97822277
134TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97723362
135SOX2_18555785_Chip-Seq_ESCs_Mouse0.97714939
136PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96773431
137ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96096977
138FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95995133
139* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95984162
140PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95702453
141SOX2_22085726_ChIP-Seq_NPCs_Mouse0.95657057
142MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95480174
143EP300_21415370_ChIP-Seq_HL-1_Mouse0.95145452
144YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94313370
145POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94035379
146* SOX2_21211035_ChIP-Seq_LN229_Gbm0.93607751
147NFYB_21822215_ChIP-Seq_K562_Human0.92576218
148LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.92429942
149ESRRB_18555785_Chip-Seq_ESCs_Mouse0.92343627
150RNF2_27304074_Chip-Seq_ESCs_Mouse0.92197383
151GATA3_21867929_ChIP-Seq_TH1_Mouse0.91940074
152SMAD4_21741376_ChIP-Seq_EPCs_Human0.91668688
153PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91545161
154RUNX1_27457419_Chip-Seq_LIVER_Mouse0.91378339
155GF1B_26923725_Chip-Seq_HPCs_Mouse0.91223059
156SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.91078950
157WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90686674
158NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90112411
159REST_18959480_ChIP-ChIP_MESCs_Mouse0.89886713
160POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88912786
161RING1B_27294783_Chip-Seq_ESCs_Mouse0.88530567
162SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88065355
163P300_19829295_ChIP-Seq_ESCs_Human0.87737967
164SOX2_16153702_ChIP-ChIP_HESCs_Human0.86270811

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.79481423
2MP0001929_abnormal_gametogenesis4.20583284
3MP0008877_abnormal_DNA_methylation4.03261639
4MP0002653_abnormal_ependyma_morphology3.22210400
5MP0000566_synostosis3.09170993
6MP0003122_maternal_imprinting2.76595888
7MP0002210_abnormal_sex_determination2.76498128
8MP0003880_abnormal_central_pattern2.65598886
9MP0002161_abnormal_fertility/fecundity2.58266882
10MP0005423_abnormal_somatic_nervous2.57006972
11MP0006292_abnormal_olfactory_placode2.52778587
12MP0009046_muscle_twitch2.43934904
13MP0003950_abnormal_plasma_membrane2.41405379
14MP0001145_abnormal_male_reproductive2.30179625
15MP0010030_abnormal_orbit_morphology2.07909307
16MP0000653_abnormal_sex_gland2.07027957
17MP0003890_abnormal_embryonic-extraembry2.03618499
18MP0001293_anophthalmia2.03477462
19MP0003937_abnormal_limbs/digits/tail_de2.01963862
20MP0005410_abnormal_fertilization12.3114815
21MP0005551_abnormal_eye_electrophysiolog1.98998470
22MP0004859_abnormal_synaptic_plasticity1.98386849
23MP0005623_abnormal_meninges_morphology1.95887194
24MP0002249_abnormal_larynx_morphology1.94807814
25MP0004270_analgesia1.93866669
26MP0000049_abnormal_middle_ear1.87222285
27MP0005499_abnormal_olfactory_system1.81877776
28MP0005394_taste/olfaction_phenotype1.81877776
29MP0003942_abnormal_urinary_system1.76934464
30MP0002009_preneoplasia1.67567006
31MP0002233_abnormal_nose_morphology1.67507818
32MP0000920_abnormal_myelination1.65619889
33MP0001986_abnormal_taste_sensitivity1.65220703
34MP0004885_abnormal_endolymph1.64085503
35MP0003938_abnormal_ear_development1.64041801
36MP0001286_abnormal_eye_development1.61367726
37MP0003635_abnormal_synaptic_transmissio1.60410057
38MP0003119_abnormal_digestive_system1.58233173
39MP0002697_abnormal_eye_size1.57574305
40MP0003121_genomic_imprinting1.56412551
41MP0001486_abnormal_startle_reflex1.55554958
42MP0008789_abnormal_olfactory_epithelium1.54915997
43MP0008057_abnormal_DNA_replication1.50691513
44MP0002084_abnormal_developmental_patter1.49021456
45MP0003329_amyloid_beta_deposits1.48254340
46MP0005451_abnormal_body_composition1.47633632
47MP0002938_white_spotting1.46918175
48MP0002064_seizures1.45949486
49MP0002092_abnormal_eye_morphology1.44397818
50MP0009745_abnormal_behavioral_response1.42256436
51MP0003011_delayed_dark_adaptation1.40871164
52MP0003136_yellow_coat_color1.39959596
53MP0002272_abnormal_nervous_system1.39890815
54MP0003935_abnormal_craniofacial_develop1.39756967
55MP0008995_early_reproductive_senescence1.39169006
56MP0003115_abnormal_respiratory_system1.35628704
57MP0002234_abnormal_pharynx_morphology1.32714100
58MP0009384_cardiac_valve_regurgitation1.32491259
59MP0000534_abnormal_ureter_morphology1.32409804
60MP0003567_abnormal_fetal_cardiomyocyte1.32211566
61MP0001440_abnormal_grooming_behavior1.31582578
62MP0002116_abnormal_craniofacial_bone1.30494873
63MP0005076_abnormal_cell_differentiation1.29434691
64MP0000383_abnormal_hair_follicle1.29214829
65MP0000428_abnormal_craniofacial_morphol1.28358111
66MP0005409_darkened_coat_color1.26757006
67MP0010094_abnormal_chromosome_stability1.25680411
68MP0002229_neurodegeneration1.24791235
69MP0002085_abnormal_embryonic_tissue1.24766773
70MP0003755_abnormal_palate_morphology1.24628927
71MP0005253_abnormal_eye_physiology1.24575075
72MP0000631_abnormal_neuroendocrine_gland1.23933844
73MP0003385_abnormal_body_wall1.22342863
74MP0001346_abnormal_lacrimal_gland1.20459622
75MP0003111_abnormal_nucleus_morphology1.17528472
76MP0002932_abnormal_joint_morphology1.16967841
77MP0004197_abnormal_fetal_growth/weight/1.16018199
78MP0003646_muscle_fatigue1.15167426
79MP0001270_distended_abdomen1.14537529
80MP0005670_abnormal_white_adipose1.14063284
81MP0005380_embryogenesis_phenotype1.11844253
82MP0001672_abnormal_embryogenesis/_devel1.11844253
83MP0002572_abnormal_emotion/affect_behav1.11405650
84MP0003984_embryonic_growth_retardation1.10365523
85MP0000678_abnormal_parathyroid_gland1.10133526
86MP0002184_abnormal_innervation1.10125242
87MP0000432_abnormal_head_morphology1.07446638
88MP0009703_decreased_birth_body1.06623268
89MP0002088_abnormal_embryonic_growth/wei1.06030899
90MP0001968_abnormal_touch/_nociception1.05129156
91MP0002063_abnormal_learning/memory/cond1.04098675
92MP0002111_abnormal_tail_morphology1.02682249
93MP0004272_abnormal_basement_membrane1.00024941
94MP0001765_abnormal_ion_homeostasis0.97749202
95MP0004233_abnormal_muscle_weight0.96091439
96MP0008932_abnormal_embryonic_tissue0.95060141
97MP0003634_abnormal_glial_cell0.94007749
98MP0005377_hearing/vestibular/ear_phenot0.93807738
99MP0003878_abnormal_ear_physiology0.93807738
100MP0002925_abnormal_cardiovascular_devel0.93376509
101MP0006072_abnormal_retinal_apoptosis0.93110394
102MP0002114_abnormal_axial_skeleton0.92940909
103MP0001299_abnormal_eye_distance/0.92618529
104MP0001529_abnormal_vocalization0.92104451
105MP0003690_abnormal_glial_cell0.90789059
106MP0000026_abnormal_inner_ear0.90776738
107MP0002081_perinatal_lethality0.90240564
108MP0003879_abnormal_hair_cell0.89842703
109MP0000462_abnormal_digestive_system0.89565854
110MP0000955_abnormal_spinal_cord0.88777188
111MP0004742_abnormal_vestibular_system0.88726960
112MP0004145_abnormal_muscle_electrophysio0.88066053
113MP0009278_abnormal_bone_marrow0.87494742
114MP0002109_abnormal_limb_morphology0.86896419
115MP0002751_abnormal_autonomic_nervous0.86057640
116MP0003077_abnormal_cell_cycle0.85997781
117MP0002734_abnormal_mechanical_nocicepti0.84796109
118MP0001502_abnormal_circadian_rhythm0.84495750
119MP0002882_abnormal_neuron_morphology0.84309780
120MP0001697_abnormal_embryo_size0.83712480
121MP0001879_abnormal_lymphatic_vessel0.83684811
122MP0005646_abnormal_pituitary_gland0.83249975
123MP0003633_abnormal_nervous_system0.82429369
124MP0001501_abnormal_sleep_pattern0.82266145
125MP0004043_abnormal_pH_regulation0.81864025
126MP0010368_abnormal_lymphatic_system0.81780382
127MP0005248_abnormal_Harderian_gland0.81482710
128MP0002736_abnormal_nociception_after0.80974764
129MP0000778_abnormal_nervous_system0.80640402
130MP0005187_abnormal_penis_morphology0.79566441
131MP0003943_abnormal_hepatobiliary_system0.78909230
132MP0001485_abnormal_pinna_reflex0.77632068
133MP0002282_abnormal_trachea_morphology0.77573970
134MP0004133_heterotaxia0.77233917
135MP0003631_nervous_system_phenotype0.75768025
136MP0003283_abnormal_digestive_organ0.75560300
137MP0002160_abnormal_reproductive_system0.75330037
138MP0004811_abnormal_neuron_physiology0.74759019
139MP0002752_abnormal_somatic_nervous0.73714467
140MP0005195_abnormal_posterior_eye0.71115346
141MP0000747_muscle_weakness0.70478964
142MP0001963_abnormal_hearing_physiology0.70226406
143MP0002066_abnormal_motor_capabilities/c0.69615803
144MP0002152_abnormal_brain_morphology0.68503914
145MP0002102_abnormal_ear_morphology0.68238537
146MP0002557_abnormal_social/conspecific_i0.65397968
147MP0000751_myopathy0.65397281
148MP0002067_abnormal_sensory_capabilities0.61601731
149MP0003045_fibrosis0.61353620
150MP0001984_abnormal_olfaction0.60799442
151MP0008569_lethality_at_weaning0.60570021
152MP0003632_abnormal_nervous_system0.59976659
153MP0000604_amyloidosis0.59593203
154MP0002928_abnormal_bile_duct0.59396137
155MP0005391_vision/eye_phenotype0.59085974
156MP0000579_abnormal_nail_morphology0.55973729
157MP0001905_abnormal_dopamine_level0.55588826
158MP0002909_abnormal_adrenal_gland0.52908465
159MP0001970_abnormal_pain_threshold0.52056765
160MP0008961_abnormal_basal_metabolism0.51911031
161MP0000537_abnormal_urethra_morphology0.50998186
162MP0004264_abnormal_extraembryonic_tissu0.50078453
163MP0005388_respiratory_system_phenotype0.48697698
164MP0002133_abnormal_respiratory_system0.48697698
165MP0002822_catalepsy0.48577003
166MP0009780_abnormal_chondrocyte_physiolo0.48324567
167MP0005535_abnormal_body_temperature0.47510821
168MP0002269_muscular_atrophy0.47034605
169MP0003861_abnormal_nervous_system0.45344129
170MP0000749_muscle_degeneration0.44406869

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.03027353
2Abnormal respiratory epithelium morphology (HP:0012253)8.18217992
3Abnormal respiratory motile cilium morphology (HP:0005938)8.18217992
4Rhinitis (HP:0012384)7.52541000
5Abnormal ciliary motility (HP:0012262)7.23541504
6Chronic bronchitis (HP:0004469)6.80081826
7Nasal polyposis (HP:0100582)5.62261392
8Infertility (HP:0000789)5.44228980
9Abnormality of the nasal mucosa (HP:0000433)4.52536717
10Bronchiectasis (HP:0002110)4.34827698
11Nephronophthisis (HP:0000090)3.64641408
12Bronchitis (HP:0012387)3.63560135
13Chronic hepatic failure (HP:0100626)3.38318388
14Recurrent otitis media (HP:0000403)3.08344920
15Occipital encephalocele (HP:0002085)3.06302939
16Recurrent sinusitis (HP:0011108)2.89733451
17Abnormality of the lower motor neuron (HP:0002366)2.89166523
18Abnormality of the renal medulla (HP:0100957)2.88538771
19Medial flaring of the eyebrow (HP:0010747)2.85557825
20Male infertility (HP:0003251)2.74007941
21Tubulointerstitial nephritis (HP:0001970)2.73395864
22Neurofibrillary tangles (HP:0002185)2.70226463
23True hermaphroditism (HP:0010459)2.53902609
24Cystic liver disease (HP:0006706)2.35605175
25Pancreatic fibrosis (HP:0100732)2.33647723
26Abnormality of the aortic arch (HP:0012303)2.32711624
27Gait imbalance (HP:0002141)2.30680863
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.29888870
29Cutaneous finger syndactyly (HP:0010554)2.20343122
30Congenital primary aphakia (HP:0007707)2.16211601
31Hepatoblastoma (HP:0002884)2.16136797
32Tubulointerstitial abnormality (HP:0001969)2.13049026
33Ectopic kidney (HP:0000086)2.10351959
34Broad palm (HP:0001169)2.07556262
35High anterior hairline (HP:0009890)2.07455103
36Chromsome breakage (HP:0040012)2.07099346
37Hyporeflexia of lower limbs (HP:0002600)2.06619434
38Fibular hypoplasia (HP:0003038)2.05879063
39Bell-shaped thorax (HP:0001591)2.04802932
40Vitreoretinal degeneration (HP:0000655)2.01407952
41Cerebral inclusion bodies (HP:0100314)2.01224386
42Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1835644
43Dynein arm defect of respiratory motile cilia (HP:0012255)11.4539418
44Absent/shortened dynein arms (HP:0200106)11.4539418
45Pancreatic cysts (HP:0001737)1.99046601
46Retinal dysplasia (HP:0007973)1.98195766
47Abnormality of the ischium (HP:0003174)1.97932518
48Amyotrophic lateral sclerosis (HP:0007354)1.95931782
49Gonadotropin excess (HP:0000837)1.95931215
50Nephrogenic diabetes insipidus (HP:0009806)1.95291782
5111 pairs of ribs (HP:0000878)1.94546803
52Neonatal short-limb short stature (HP:0008921)1.92193633
53Aplasia/Hypoplasia of the lens (HP:0008063)1.92167018
54Abnormality of midbrain morphology (HP:0002418)1.91180750
55Molar tooth sign on MRI (HP:0002419)1.91180750
56Short nail (HP:0001799)1.90655211
57Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.89664205
58Short 4th metacarpal (HP:0010044)1.89664205
59Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.87619406
60Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87286356
61Cutaneous syndactyly (HP:0012725)1.86364284
62Preaxial hand polydactyly (HP:0001177)1.86029657
63Abnormality of cochlea (HP:0000375)1.84841310
64Midline defect of the nose (HP:0004122)1.84514331
65Polydipsia (HP:0001959)1.84007504
66Abnormal drinking behavior (HP:0030082)1.84007504
67Stage 5 chronic kidney disease (HP:0003774)1.83271200
68Supranuclear gaze palsy (HP:0000605)1.81982080
69Sensory axonal neuropathy (HP:0003390)1.81936150
70Spastic tetraparesis (HP:0001285)1.80921906
71Renal dysplasia (HP:0000110)1.80632370
72Vertebral arch anomaly (HP:0008438)1.80597319
73Anophthalmia (HP:0000528)1.79607284
74Abnormality of the pubic bones (HP:0003172)1.79151880
75Genetic anticipation (HP:0003743)1.78292054
76Bony spicule pigmentary retinopathy (HP:0007737)1.77752010
77Congenital hepatic fibrosis (HP:0002612)1.77264593
78Abnormality of the renal cortex (HP:0011035)1.77151162
79Anencephaly (HP:0002323)1.76587779
80Trigonocephaly (HP:0000243)1.76345232
81Broad finger (HP:0001500)1.76325956
82Broad alveolar ridges (HP:0000187)1.76068105
83Genital tract atresia (HP:0001827)1.75822276
84Hypoplastic ischia (HP:0003175)1.75819248
85Abnormality of macular pigmentation (HP:0008002)1.75154475
86Heterotopia (HP:0002282)1.74711318
87Irregular epiphyses (HP:0010582)1.74417097
88Optic nerve coloboma (HP:0000588)1.73422084
89Vaginal atresia (HP:0000148)1.72771256
90Short thorax (HP:0010306)1.72735330
91Abnormal spermatogenesis (HP:0008669)1.71992386
92Broad phalanges of the hand (HP:0009768)1.71934514
93Poor coordination (HP:0002370)1.71755720
94Degeneration of the lateral corticospinal tracts (HP:0002314)1.71244466
95Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.71244466
96Bronchomalacia (HP:0002780)1.71070642
97Tubular atrophy (HP:0000092)1.70084258
98Prolonged QT interval (HP:0001657)1.68297033
99Choroideremia (HP:0001139)1.68137755
100Bilateral microphthalmos (HP:0007633)1.67256652
101Broad thumb (HP:0011304)1.67056016
102Obsessive-compulsive behavior (HP:0000722)1.66318425
103Absent epiphyses (HP:0010577)1.66072202
104Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.66072202
105Broad distal phalanx of finger (HP:0009836)1.65960003
106Focal motor seizures (HP:0011153)1.64740111
107Chronic sinusitis (HP:0011109)1.64566592
108Preaxial foot polydactyly (HP:0001841)1.63503132
109Renovascular hypertension (HP:0100817)1.62937665
110Bifid tongue (HP:0010297)1.61255779
111Postaxial foot polydactyly (HP:0001830)1.61039100
112Broad phalanx (HP:0006009)1.60742877
113Bundle branch block (HP:0011710)1.60454405
114Sclerocornea (HP:0000647)1.60313068
115Dyschromatopsia (HP:0007641)1.59487660
116Decreased central vision (HP:0007663)1.59459440
117Abnormality of abdominal situs (HP:0011620)1.58998953
118Abdominal situs inversus (HP:0003363)1.58998953
119Omphalocele (HP:0001539)1.58958125
120Atelectasis (HP:0100750)1.58707942
121Abnormality of dentin (HP:0010299)1.58154205
122Broad foot (HP:0001769)1.58107862
123Abnormality of the ileum (HP:0001549)1.57855018
124Sandal gap (HP:0001852)1.56835606
125Intellectual disability, moderate (HP:0002342)1.56805330
126Abnormality of the epiphyses of the hand (HP:0005924)1.56174281
127Tubulointerstitial fibrosis (HP:0005576)1.55004681
128Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.54981603
129Hemiparesis (HP:0001269)1.54840789
130Abnormality of the calcaneus (HP:0008364)1.54298851
131Abnormality of the 4th metacarpal (HP:0010012)1.54284621
132Meckel diverticulum (HP:0002245)1.53988483
133Aplasia/Hypoplasia of the sternum (HP:0006714)1.53967757
134Broad long bones (HP:0005622)1.53349283
135Congenital stationary night blindness (HP:0007642)1.52860592
136Recurrent bronchitis (HP:0002837)1.52545675
137Sloping forehead (HP:0000340)1.52202080
138Rib fusion (HP:0000902)1.50228665
139Postaxial hand polydactyly (HP:0001162)1.48228086
140Facial cleft (HP:0002006)1.47063638
141Abnormal EKG (HP:0003115)1.47031435
142Flattened epiphyses (HP:0003071)1.46682814
143Aplasia/Hypoplasia of the fibula (HP:0006492)1.45826978
144Short ribs (HP:0000773)1.42806997
145Cone-rod dystrophy (HP:0000548)1.41833791
146Retinitis pigmentosa (HP:0000510)1.41530428
147Pachygyria (HP:0001302)1.41302281
148Supernumerary spleens (HP:0009799)1.41292566
149Abnormality of ocular smooth pursuit (HP:0000617)1.41111061
150Abnormality of permanent molar morphology (HP:0011071)1.39411613
151Abnormality of the dental root (HP:0006486)1.39411613
152Taurodontia (HP:0000679)1.39411613
153Abolished electroretinogram (ERG) (HP:0000550)1.37423644
154Small epiphyses (HP:0010585)1.35908119
155Progressive cerebellar ataxia (HP:0002073)1.35251873
156Postural instability (HP:0002172)1.34395355
157Abnormality of molar (HP:0011077)1.33159771
158Abnormality of molar morphology (HP:0011070)1.33159771
159Attenuation of retinal blood vessels (HP:0007843)1.32766283
160Azoospermia (HP:0000027)1.31403930
161Impulsivity (HP:0100710)1.31261424
162Abnormality of the corticospinal tract (HP:0002492)1.30934542
163Abnormality of saccadic eye movements (HP:0000570)1.30890056
164Onion bulb formation (HP:0003383)1.29951317
165Widely spaced teeth (HP:0000687)1.29312777

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.27900372
2PDK47.27900372
3PDK24.79694471
4STK393.80968844
5PRKD33.78855723
6TESK13.34859871
7ICK3.06895957
8PNCK2.65340355
9WNK42.55985501
10LATS12.53179052
11SIK22.31818115
12BRD42.30803989
13EEF2K2.22944255
14MAP3K102.15229035
15TNIK2.14398500
16PTK2B2.02797637
17NTRK32.02781580
18WNK11.93977930
19BCR1.90599094
20MAP3K71.90570887
21FLT31.84277735
22EPHA41.78770336
23OXSR11.71438543
24PLK41.68787574
25PKN21.63692877
26PINK11.59084745
27MKNK21.56951890
28MKNK11.54525262
29SRPK11.53631715
30CDC71.45248022
31TRIB31.44464925
32PDGFRA1.44454857
33STK381.38549918
34MAP4K21.36262233
35NME11.27350024
36FGFR11.24068468
37MAPK151.20833957
38GRK11.20809761
39ATR1.12131723
40CAMK1D1.10785113
41PDK11.08262987
42FGFR41.04278453
43ERBB21.02078483
44DYRK1A1.00390745
45NEK20.98244040
46CASK0.96792746
47PKN10.93924569
48MAPKAPK50.93898954
49MAP3K40.92995732
50CDK190.92374641
51FGFR30.89963468
52BRSK20.86606384
53CAMK1G0.86025136
54BCKDK0.85808618
55PAK60.85725591
56INSRR0.85280465
57MARK20.84759898
58CDK80.84247335
59LMTK20.83231837
60CDK120.81724457
61PDPK10.77439576
62RPS6KA40.75289064
63RIPK40.74738328
64ATM0.70598350
65PRKCG0.70470948
66MARK10.70444659
67SGK20.69599218
68BMPR1B0.69044753
69AKT30.69037401
70ZAK0.68274448
71BMX0.66695593
72STK38L0.66169938
73MAP2K60.66014153
74TYRO30.65614653
75YES10.65450339
76CDK20.64985322
77CDK10.62744501
78CAMKK10.62069829
79CAMK2B0.60904225
80CAMK2D0.60636542
81TLK10.59227454
82MAP2K70.57542337
83NEK60.57464969
84CDK40.57057958
85PRKAA20.55975616
86STK110.54429921
87SGK10.53595991
88CAMK2A0.53259792
89NTRK20.53202306
90GSK3B0.52087349
91NTRK10.51853991
92PBK0.51220263
93DYRK1B0.51158121
94FRK0.50972442
95TESK20.50531270
96PTK20.50481029
97PLK10.46758382
98PRKDC0.45508643
99PHKG10.44347231
100PHKG20.44347231
101DYRK30.44079803
102EPHB20.44068506
103WEE10.44038296
104MAPK10.43577512
105CDK50.43489745
106CDK90.43207979
107CDK70.42412957
108CDK60.41828512
109MAPK140.41475808
110RPS6KA60.41422567
111FGFR20.41130334
112NLK0.41110107
113CAMK10.38771353
114TTK0.38480112
115CAMK2G0.38129120
116WNK30.37049798
117LIMK10.36728746
118MAP3K90.36066686
119PRKAA10.35807593
120CHEK20.34373906
121CDK150.34313176
122MAP2K40.33135607
123CDK30.33022830
124MAP3K60.32013549
125PASK0.31318233
126PRKCQ0.31167664
127PDGFRB0.28767808
128CAMKK20.28729804
129CDK180.28231553
130CDK140.27461030
131KSR20.27242746
132CDK11A0.27175012
133PRKG10.27141324
134SGK4940.26975802
135SGK2230.26975802
136ALK0.26268476
137PRKCZ0.24395444
138MAPK100.22690140
139MET0.21618374
140EPHB10.20745437
141MTOR0.20263450
142STK30.19615310
143CSNK1E0.19452699
144RET0.19327962
145CSNK1D0.18771551
146MARK30.18430942
147GRK70.18324875
148CHEK10.18289491
149CLK10.17007646
150CDC42BPA0.16731223
151PRKCH0.16408880
152DDR20.16209437
153FYN0.15483964
154PRKCA0.15365094
155PRKCB0.14357516
156RPS6KA30.13432248
157PRKACA0.12477093

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.37663479
2Phototransduction_Homo sapiens_hsa047443.59243734
3Pyruvate metabolism_Homo sapiens_hsa006202.39249575
4Lysine degradation_Homo sapiens_hsa003102.33247795
5Basal cell carcinoma_Homo sapiens_hsa052172.17058200
6Fanconi anemia pathway_Homo sapiens_hsa034602.15426112
7Hedgehog signaling pathway_Homo sapiens_hsa043402.14879721
8mRNA surveillance pathway_Homo sapiens_hsa030152.14811520
9Dorso-ventral axis formation_Homo sapiens_hsa043202.13711392
10Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.08029153
11Propanoate metabolism_Homo sapiens_hsa006402.05770148
12Glucagon signaling pathway_Homo sapiens_hsa049222.04174412
13Fatty acid biosynthesis_Homo sapiens_hsa000611.97167501
14Amphetamine addiction_Homo sapiens_hsa050311.92764715
15Linoleic acid metabolism_Homo sapiens_hsa005911.91069442
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.89117917
17Ether lipid metabolism_Homo sapiens_hsa005651.80103876
18Synaptic vesicle cycle_Homo sapiens_hsa047211.75554817
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.66483127
20Taste transduction_Homo sapiens_hsa047421.66015268
21Cardiac muscle contraction_Homo sapiens_hsa042601.65928443
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.64866352
23Glutamatergic synapse_Homo sapiens_hsa047241.59362842
24Renin secretion_Homo sapiens_hsa049241.55602376
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55014250
26Huntingtons disease_Homo sapiens_hsa050161.54006081
27Hippo signaling pathway_Homo sapiens_hsa043901.53760692
28Steroid biosynthesis_Homo sapiens_hsa001001.52272246
29Fatty acid elongation_Homo sapiens_hsa000621.51756926
30Adherens junction_Homo sapiens_hsa045201.51199086
31Glycerolipid metabolism_Homo sapiens_hsa005611.50787088
32Oocyte meiosis_Homo sapiens_hsa041141.50500924
33Homologous recombination_Homo sapiens_hsa034401.49118518
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.48227022
35Insulin secretion_Homo sapiens_hsa049111.46249729
36Nicotine addiction_Homo sapiens_hsa050331.45051584
37Notch signaling pathway_Homo sapiens_hsa043301.43851762
38RNA transport_Homo sapiens_hsa030131.42260531
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38783521
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.37755991
41Long-term potentiation_Homo sapiens_hsa047201.37401340
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36475215
43Non-homologous end-joining_Homo sapiens_hsa034501.35571520
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33971871
45Cell cycle_Homo sapiens_hsa041101.33365744
46Base excision repair_Homo sapiens_hsa034101.31269429
47Olfactory transduction_Homo sapiens_hsa047401.30124732
48Calcium signaling pathway_Homo sapiens_hsa040201.29615204
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28673159
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28306921
51ECM-receptor interaction_Homo sapiens_hsa045121.27484702
52Sphingolipid metabolism_Homo sapiens_hsa006001.27356786
53Spliceosome_Homo sapiens_hsa030401.24211046
54Pentose phosphate pathway_Homo sapiens_hsa000301.21719005
55Nucleotide excision repair_Homo sapiens_hsa034201.21305956
56Sulfur metabolism_Homo sapiens_hsa009201.19232469
57Choline metabolism in cancer_Homo sapiens_hsa052311.16940305
58MicroRNAs in cancer_Homo sapiens_hsa052061.16504082
59Gastric acid secretion_Homo sapiens_hsa049711.16479377
60Salivary secretion_Homo sapiens_hsa049701.15726321
61Collecting duct acid secretion_Homo sapiens_hsa049661.13600202
62Selenocompound metabolism_Homo sapiens_hsa004501.12105767
63Circadian entrainment_Homo sapiens_hsa047131.11850330
64Morphine addiction_Homo sapiens_hsa050321.11802630
65Basal transcription factors_Homo sapiens_hsa030221.10776880
66Wnt signaling pathway_Homo sapiens_hsa043101.10184795
67RNA degradation_Homo sapiens_hsa030181.09133549
68Cocaine addiction_Homo sapiens_hsa050301.08343567
69TGF-beta signaling pathway_Homo sapiens_hsa043501.06532245
70Mineral absorption_Homo sapiens_hsa049781.06482734
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.04554549
72GABAergic synapse_Homo sapiens_hsa047271.04316783
73Circadian rhythm_Homo sapiens_hsa047101.01670933
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00427585
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.00159145
76mTOR signaling pathway_Homo sapiens_hsa041501.00118927
77PPAR signaling pathway_Homo sapiens_hsa033200.99452436
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98974412
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98966990
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97878672
81One carbon pool by folate_Homo sapiens_hsa006700.97162029
82DNA replication_Homo sapiens_hsa030300.95716321
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95641462
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93256254
85Mismatch repair_Homo sapiens_hsa034300.92758968
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90636792
87ErbB signaling pathway_Homo sapiens_hsa040120.89847577
88Type II diabetes mellitus_Homo sapiens_hsa049300.89838929
89Axon guidance_Homo sapiens_hsa043600.89389859
90cAMP signaling pathway_Homo sapiens_hsa040240.89293815
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87473738
92Estrogen signaling pathway_Homo sapiens_hsa049150.86125999
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.83797428
94Pancreatic secretion_Homo sapiens_hsa049720.83163159
95Oxytocin signaling pathway_Homo sapiens_hsa049210.81655816
96Colorectal cancer_Homo sapiens_hsa052100.80261696
97Fatty acid metabolism_Homo sapiens_hsa012120.79636618
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79355073
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78722749
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77689802
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77202473
102Dopaminergic synapse_Homo sapiens_hsa047280.76051115
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75691696
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75493969
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74525429
106Alcoholism_Homo sapiens_hsa050340.74112387
107ABC transporters_Homo sapiens_hsa020100.73589709
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70887085
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70642710
110Small cell lung cancer_Homo sapiens_hsa052220.70458338
111Inositol phosphate metabolism_Homo sapiens_hsa005620.69476825
112Chronic myeloid leukemia_Homo sapiens_hsa052200.68436581
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67342280
114Cholinergic synapse_Homo sapiens_hsa047250.64200737
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62669418
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.62268922
117Prostate cancer_Homo sapiens_hsa052150.61613396
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60892691
119Asthma_Homo sapiens_hsa053100.60883414
120Serotonergic synapse_Homo sapiens_hsa047260.60278954
121Melanogenesis_Homo sapiens_hsa049160.58935581
122Biosynthesis of amino acids_Homo sapiens_hsa012300.57223834
123Endocytosis_Homo sapiens_hsa041440.57128900
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.56840877
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.56740178
126Fructose and mannose metabolism_Homo sapiens_hsa000510.54929293
127FoxO signaling pathway_Homo sapiens_hsa040680.54808023
128Alzheimers disease_Homo sapiens_hsa050100.54509872
129Focal adhesion_Homo sapiens_hsa045100.52566917
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52522507
131Insulin signaling pathway_Homo sapiens_hsa049100.51653453
132Pathways in cancer_Homo sapiens_hsa052000.51073806
133N-Glycan biosynthesis_Homo sapiens_hsa005100.50138260
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49131304
135Oxidative phosphorylation_Homo sapiens_hsa001900.48877428
136Insulin resistance_Homo sapiens_hsa049310.48167528
137Thyroid hormone synthesis_Homo sapiens_hsa049180.47552574
138Complement and coagulation cascades_Homo sapiens_hsa046100.47481380
139Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46799353
140Protein digestion and absorption_Homo sapiens_hsa049740.46797868
141Endometrial cancer_Homo sapiens_hsa052130.46560006
142Prolactin signaling pathway_Homo sapiens_hsa049170.45934907
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45482514
144Carbon metabolism_Homo sapiens_hsa012000.44880015
145p53 signaling pathway_Homo sapiens_hsa041150.44758538
146Long-term depression_Homo sapiens_hsa047300.44206830
147Neurotrophin signaling pathway_Homo sapiens_hsa047220.44133671
148Nitrogen metabolism_Homo sapiens_hsa009100.43998487
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.41664603
150Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39526556
151Purine metabolism_Homo sapiens_hsa002300.36732061
152Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32884201
153Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32861045
154Cysteine and methionine metabolism_Homo sapiens_hsa002700.32468760
155Bile secretion_Homo sapiens_hsa049760.32317548
156Metabolic pathways_Homo sapiens_hsa011000.31672522
157Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31297652
158Tight junction_Homo sapiens_hsa045300.29318419
159Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28599741
160AMPK signaling pathway_Homo sapiens_hsa041520.27853016
161Steroid hormone biosynthesis_Homo sapiens_hsa001400.27417845
162Butanoate metabolism_Homo sapiens_hsa006500.23721151
163Fatty acid degradation_Homo sapiens_hsa000710.23426275

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »