WDR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD repeat family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)4.97854144
2nuclear pore complex assembly (GO:0051292)4.85255371
3nucleobase biosynthetic process (GO:0046112)4.62010121
4DNA unwinding involved in DNA replication (GO:0006268)4.60794452
5protein localization to kinetochore (GO:0034501)4.60444023
6formation of translation preinitiation complex (GO:0001731)4.33156428
7mitotic nuclear envelope disassembly (GO:0007077)4.30487650
8purine nucleobase biosynthetic process (GO:0009113)4.29802641
9IMP biosynthetic process (GO:0006188)4.29643461
10DNA replication initiation (GO:0006270)4.19444755
11establishment of integrated proviral latency (GO:0075713)4.17166494
12folic acid-containing compound biosynthetic process (GO:0009396)4.13112666
13mitotic metaphase plate congression (GO:0007080)4.09737364
14DNA strand elongation involved in DNA replication (GO:0006271)4.03918113
15non-recombinational repair (GO:0000726)4.03786674
16double-strand break repair via nonhomologous end joining (GO:0006303)4.03786674
17membrane disassembly (GO:0030397)4.01514096
18nuclear envelope disassembly (GO:0051081)4.01514096
19maturation of SSU-rRNA (GO:0030490)4.00296375
20ribosome assembly (GO:0042255)3.95315052
21IMP metabolic process (GO:0046040)3.91213406
22ribosome biogenesis (GO:0042254)3.87557295
23DNA strand elongation (GO:0022616)3.86858792
24pore complex assembly (GO:0046931)3.82028896
25DNA replication-dependent nucleosome organization (GO:0034723)3.75922219
26DNA replication-dependent nucleosome assembly (GO:0006335)3.75922219
27protein localization to chromosome, centromeric region (GO:0071459)3.75642292
28ribosomal small subunit assembly (GO:0000028)3.71226683
29maturation of 5.8S rRNA (GO:0000460)3.70863228
30regulation of translational fidelity (GO:0006450)3.70321752
31regulation of centriole replication (GO:0046599)3.68452270
32telomere maintenance via semi-conservative replication (GO:0032201)3.66783879
33metaphase plate congression (GO:0051310)3.60794498
34ribosomal large subunit biogenesis (GO:0042273)3.60550175
35ribonucleoprotein complex biogenesis (GO:0022613)3.54933000
36DNA replication checkpoint (GO:0000076)3.49022444
37DNA duplex unwinding (GO:0032508)3.48300946
38regulation of spindle organization (GO:0090224)3.48224194
39telomere maintenance via recombination (GO:0000722)3.47638325
40DNA geometric change (GO:0032392)3.46989638
41tRNA aminoacylation for protein translation (GO:0006418)3.45237217
42mitotic recombination (GO:0006312)3.42933214
43amino acid activation (GO:0043038)3.41058279
44tRNA aminoacylation (GO:0043039)3.41058279
45chromatin remodeling at centromere (GO:0031055)3.33825515
46regulation of histone H3-K9 methylation (GO:0051570)3.33703694
47mitochondrial RNA metabolic process (GO:0000959)3.33451644
48mitotic chromosome condensation (GO:0007076)3.33178227
49CENP-A containing nucleosome assembly (GO:0034080)3.31494553
50DNA topological change (GO:0006265)3.30939860
51rRNA processing (GO:0006364)3.30397197
52mitotic sister chromatid segregation (GO:0000070)3.28638844
53kinetochore organization (GO:0051383)3.28620395
54regulation of translational termination (GO:0006449)3.26740096
55establishment of chromosome localization (GO:0051303)3.24850981
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.23418055
57positive regulation of chromosome segregation (GO:0051984)3.22918165
58rRNA metabolic process (GO:0016072)3.21851085
59DNA replication-independent nucleosome assembly (GO:0006336)3.21407425
60DNA replication-independent nucleosome organization (GO:0034724)3.21407425
61attachment of spindle microtubules to kinetochore (GO:0008608)3.20270609
62negative regulation of histone methylation (GO:0031061)3.20176822
63sister chromatid segregation (GO:0000819)3.20046664
64protein complex localization (GO:0031503)3.19757710
65negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.17328532
66regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.15608270
67transcription from mitochondrial promoter (GO:0006390)3.15262201
68telomere maintenance via telomere lengthening (GO:0010833)3.15050375
69regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.14504964
70nuclear envelope organization (GO:0006998)3.12787964
71DNA ligation (GO:0006266)3.12602322
72spliceosomal snRNP assembly (GO:0000387)3.12013297
73replication fork processing (GO:0031297)3.10476926
74folic acid metabolic process (GO:0046655)3.09570521
75DNA synthesis involved in DNA repair (GO:0000731)3.07671398
76regulation of mitotic spindle organization (GO:0060236)3.07554220
77somatic hypermutation of immunoglobulin genes (GO:0016446)3.07531574
78somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07531574
79regulation of mitotic sister chromatid separation (GO:0010965)3.06101552
80regulation of mitotic sister chromatid segregation (GO:0033047)3.06101552
81regulation of sister chromatid segregation (GO:0033045)3.06101552
82mitotic sister chromatid cohesion (GO:0007064)3.03708018
83translational initiation (GO:0006413)3.00430761
84nucleotide-excision repair, DNA gap filling (GO:0006297)2.99796716
85establishment of viral latency (GO:0019043)2.99238521
86regulation of centrosome duplication (GO:0010824)2.98518200
87regulation of sister chromatid cohesion (GO:0007063)2.97873769
88translational termination (GO:0006415)2.97768354
89regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.97185477
90cellular protein complex localization (GO:0034629)2.96612489
91pteridine-containing compound biosynthetic process (GO:0042559)2.96214635
92pseudouridine synthesis (GO:0001522)2.95228495
93regulation of DNA endoreduplication (GO:0032875)2.94560655
94spindle checkpoint (GO:0031577)2.92509681
95chromatin assembly or disassembly (GO:0006333)2.91927982
96pre-miRNA processing (GO:0031054)2.91823757
97viral transcription (GO:0019083)2.91814674
98viral mRNA export from host cell nucleus (GO:0046784)2.91610837
99RNA splicing, via transesterification reactions (GO:0000375)2.91506972
100proteasome assembly (GO:0043248)2.90872224
101negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.90815794
102mRNA splicing, via spliceosome (GO:0000398)2.89874085
103RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.89874085
104positive regulation of mitotic sister chromatid separation (GO:1901970)2.87814974
105positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.87814974
106positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.87814974
107negative regulation of chromosome segregation (GO:0051985)2.87732743
108regulation of gene silencing by RNA (GO:0060966)2.87420424
109regulation of posttranscriptional gene silencing (GO:0060147)2.87420424
110regulation of gene silencing by miRNA (GO:0060964)2.87420424
111mitotic spindle checkpoint (GO:0071174)2.87335722
112ribosomal small subunit biogenesis (GO:0042274)2.87015408
113regulation of chromosome segregation (GO:0051983)2.86719054
114spindle assembly checkpoint (GO:0071173)2.86543776
115meiotic chromosome segregation (GO:0045132)2.85668829
116histone exchange (GO:0043486)2.85609375
117regulation of mitotic metaphase/anaphase transition (GO:0030071)2.85409512
118spliceosomal tri-snRNP complex assembly (GO:0000244)2.85241380
119mitotic spindle assembly checkpoint (GO:0007094)2.84487509
120negative regulation of mitotic sister chromatid separation (GO:2000816)2.84355534
121negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84355534
122negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84355534
123negative regulation of sister chromatid segregation (GO:0033046)2.84355534
124heterochromatin organization (GO:0070828)2.83188992
125protein localization to chromosome (GO:0034502)2.82737244
126regulation of helicase activity (GO:0051095)2.82562985
127DNA conformation change (GO:0071103)2.81861207
128regulation of RNA export from nucleus (GO:0046831)2.81603375
129regulation of centrosome cycle (GO:0046605)2.80838473
130chromatin assembly (GO:0031497)2.80592187
131nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.80288563
132mRNA transport (GO:0051028)2.79443579
133kinetochore assembly (GO:0051382)2.78130024

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.14733438
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.11991219
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.09354892
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.71546595
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.39048232
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.99753904
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.96288930
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.76431154
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73627242
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.65397530
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.49646272
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.49103003
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.47726685
14* GABP_17652178_ChIP-ChIP_JURKAT_Human2.44503202
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.38353663
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33186785
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.30666510
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.23156048
19XRN2_22483619_ChIP-Seq_HELA_Human2.13551487
20VDR_23849224_ChIP-Seq_CD4+_Human2.12971645
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.10193134
22MYC_22102868_ChIP-Seq_BL_Human2.03984592
23AR_21909140_ChIP-Seq_LNCAP_Human2.03905244
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99997144
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94013176
26FOXP3_21729870_ChIP-Seq_TREG_Human1.92861250
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90630867
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89391240
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88127016
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77707920
31* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77283230
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76232854
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75262725
34ELK1_19687146_ChIP-ChIP_HELA_Human1.74977571
35DCP1A_22483619_ChIP-Seq_HELA_Human1.73333296
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72726506
37CIITA_25753668_ChIP-Seq_RAJI_Human1.71848446
38GABP_19822575_ChIP-Seq_HepG2_Human1.67855529
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66672201
40TTF2_22483619_ChIP-Seq_HELA_Human1.60717957
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58960048
42KDM5A_27292631_Chip-Seq_BREAST_Human1.55885339
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55054934
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53231491
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52857254
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52070893
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.51560981
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50309702
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.48122598
50* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47995486
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43574692
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38352364
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37227522
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36268738
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35118422
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34205918
57TFEB_21752829_ChIP-Seq_HELA_Human1.33672595
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32320639
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30029390
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28836552
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27059239
62SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.25290154
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.25200988
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.23630055
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22285892
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19589586
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.18904832
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13300430
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12767929
70EWS_26573619_Chip-Seq_HEK293_Human1.10895161
71* SOX17_20123909_ChIP-Seq_XEN_Mouse1.10464514
72* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10182314
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09439324
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08762319
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08705398
76SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07751400
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07362270
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06560914
79SPI1_23547873_ChIP-Seq_NB4_Human1.05275493
80VDR_21846776_ChIP-Seq_THP-1_Human1.04241176
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03022228
82IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00568029
83CHD1_26751641_Chip-Seq_LNCaP_Human1.00526064
84CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98982188
85SRF_21415370_ChIP-Seq_HL-1_Mouse0.97830646
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97171359
87SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96356797
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92897007
89CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92798749
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92464156
91NANOG_16153702_ChIP-ChIP_HESCs_Human0.92326643
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91855621
93FUS_26573619_Chip-Seq_HEK293_Human0.90344382
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90250715
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88262308
96SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.87855186
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87402073
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86379077
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84473524
100MYB_26560356_Chip-Seq_TH1_Human0.83974580
101SOX2_16153702_ChIP-ChIP_HESCs_Human0.83666987
102HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83610379
103NANOG_21062744_ChIP-ChIP_HESCs_Human0.83558053
104* MYC_18940864_ChIP-ChIP_HL60_Human0.83016881
105* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82668595
106ELK1_22589737_ChIP-Seq_MCF10A_Human0.81049698
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.79621464
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79246094
109MYB_26560356_Chip-Seq_TH2_Human0.79161616
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78297839
111TCF3_18692474_ChIP-Seq_MEFs_Mouse0.77765020
112PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.77078589
113TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.75985931
114CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.72541020
115DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.70794452
116ELF5_23300383_ChIP-Seq_T47D_Human0.67557847
117* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.65074459

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.94225158
2MP0010094_abnormal_chromosome_stability4.40328664
3MP0003111_abnormal_nucleus_morphology4.21600275
4MP0004957_abnormal_blastocyst_morpholog4.14570639
5MP0008057_abnormal_DNA_replication4.05189934
6MP0003077_abnormal_cell_cycle3.79376361
7MP0008058_abnormal_DNA_repair3.12214720
8MP0002396_abnormal_hematopoietic_system2.92394265
9MP0010352_gastrointestinal_tract_polyps2.80087469
10MP0008007_abnormal_cellular_replicative2.68135296
11MP0009697_abnormal_copulation2.44015273
12MP0010307_abnormal_tumor_latency2.41417783
13MP0001730_embryonic_growth_arrest2.41205214
14MP0003123_paternal_imprinting2.32316983
15MP0000350_abnormal_cell_proliferation2.32037914
16MP0008932_abnormal_embryonic_tissue2.25827017
17MP0008877_abnormal_DNA_methylation2.11936863
18MP0003941_abnormal_skin_development2.01099435
19MP0003786_premature_aging1.94109811
20MP0001672_abnormal_embryogenesis/_devel1.80532768
21MP0005380_embryogenesis_phenotype1.80532768
22MP0004808_abnormal_hematopoietic_stem1.79808013
23MP0000490_abnormal_crypts_of1.77777785
24MP0002009_preneoplasia1.72953548
25MP0005076_abnormal_cell_differentiation1.67310249
26MP0001697_abnormal_embryo_size1.66774574
27MP0003984_embryonic_growth_retardation1.64732255
28MP0002080_prenatal_lethality1.62039609
29MP0002088_abnormal_embryonic_growth/wei1.61539416
30MP0009333_abnormal_splenocyte_physiolog1.60698221
31MP0002086_abnormal_extraembryonic_tissu1.55126691
32MP0003937_abnormal_limbs/digits/tail_de1.52591535
33MP0004197_abnormal_fetal_growth/weight/1.51960145
34MP0003806_abnormal_nucleotide_metabolis1.51202948
35MP0003763_abnormal_thymus_physiology1.49824840
36MP0003315_abnormal_perineum_morphology1.49641550
37MP0001661_extended_life_span1.49494234
38MP0003567_abnormal_fetal_cardiomyocyte1.46305084
39MP0002019_abnormal_tumor_incidence1.46095282
40MP0002084_abnormal_developmental_patter1.44553732
41MP0002398_abnormal_bone_marrow1.43571092
42MP0002085_abnormal_embryonic_tissue1.42496888
43MP0000313_abnormal_cell_death1.38874575
44MP0005187_abnormal_penis_morphology1.36478535
45MP0000703_abnormal_thymus_morphology1.35199048
46MP0006035_abnormal_mitochondrial_morpho1.33223864
47MP0002722_abnormal_immune_system1.28572024
48MP0002938_white_spotting1.28530796
49MP0004233_abnormal_muscle_weight1.27625103
50MP0000689_abnormal_spleen_morphology1.26217016
51MP0003705_abnormal_hypodermis_morpholog1.25574323
52MP0001545_abnormal_hematopoietic_system1.21795853
53MP0005397_hematopoietic_system_phenotyp1.21795853
54MP0003121_genomic_imprinting1.20252029
55MP0002697_abnormal_eye_size1.18592014
56MP0005408_hypopigmentation1.17634719
57MP0001835_abnormal_antigen_presentation1.14028628
58MP0003890_abnormal_embryonic-extraembry1.10646610
59MP0001800_abnormal_humoral_immune1.10270204
60MP0003718_maternal_effect1.09535536
61MP0001293_anophthalmia1.09116155
62MP0003136_yellow_coat_color1.08438513
63MP0002429_abnormal_blood_cell1.04861087
64MP0002160_abnormal_reproductive_system1.03297607
65MP0002210_abnormal_sex_determination1.01202316
66MP0003950_abnormal_plasma_membrane0.99099018
67MP0003566_abnormal_cell_adhesion0.98965024
68MP0001286_abnormal_eye_development0.98034852
69MP0000716_abnormal_immune_system0.97659757
70MP0000372_irregular_coat_pigmentation0.95271056
71MP0005171_absent_coat_pigmentation0.95113786
72MP0002877_abnormal_melanocyte_morpholog0.93833470
73MP0005023_abnormal_wound_healing0.93762039
74MP0000858_altered_metastatic_potential0.92310995
75MP0001145_abnormal_male_reproductive0.91760924
76MP0002452_abnormal_antigen_presenting0.91744855
77MP0009672_abnormal_birth_weight0.91592061
78MP0010678_abnormal_skin_adnexa0.90746966
79MP0005671_abnormal_response_to0.89791355
80MP0005075_abnormal_melanosome_morpholog0.89527474
81MP0000647_abnormal_sebaceous_gland0.89154236
82MP0000465_gastrointestinal_hemorrhage0.88507983
83MP0001915_intracranial_hemorrhage0.88236413
84MP0002420_abnormal_adaptive_immunity0.88034797
85MP0001819_abnormal_immune_cell0.86349169
86MP0005621_abnormal_cell_physiology0.86157910
87MP0003436_decreased_susceptibility_to0.85735613
88MP0000371_diluted_coat_color0.85277386
89MP0006054_spinal_hemorrhage0.84730845
90MP0005384_cellular_phenotype0.84380764
91MP0004185_abnormal_adipocyte_glucose0.83771794
92MP0001853_heart_inflammation0.83381383
93MP0000579_abnormal_nail_morphology0.83247553
94MP0003943_abnormal_hepatobiliary_system0.81311787
95MP0000358_abnormal_cell_content/0.79912905
96MP0003221_abnormal_cardiomyocyte_apopto0.78044344
97MP0009278_abnormal_bone_marrow0.77929334
98MP0009703_decreased_birth_body0.77352729
99MP0003385_abnormal_body_wall0.77205805
100MP0000569_abnormal_digit_pigmentation0.76300765
101MP0002723_abnormal_immune_serum0.75836403
102MP0002233_abnormal_nose_morphology0.75623036
103MP0004264_abnormal_extraembryonic_tissu0.74541577
104MP0000653_abnormal_sex_gland0.74533471
105MP0002405_respiratory_system_inflammati0.74176444
106MP0000685_abnormal_immune_system0.72927349
107MP0002234_abnormal_pharynx_morphology0.72383609
108MP0002092_abnormal_eye_morphology0.72201466
109MP0002166_altered_tumor_susceptibility0.72166304
110MP0003755_abnormal_palate_morphology0.71578658
111MP0005501_abnormal_skin_physiology0.71171344
112MP0000477_abnormal_intestine_morphology0.70915553
113MP0003935_abnormal_craniofacial_develop0.70373226
114MP0001346_abnormal_lacrimal_gland0.69372691
115MP0001929_abnormal_gametogenesis0.68788049
116MP0003186_abnormal_redox_activity0.68486594
117MP0006036_abnormal_mitochondrial_physio0.68020998
118MP0010155_abnormal_intestine_physiology0.67285765
119MP0000427_abnormal_hair_cycle0.66782120
120MP0000383_abnormal_hair_follicle0.66077087
121MP0003448_altered_tumor_morphology0.66015209
122MP0002111_abnormal_tail_morphology0.65539289
123MP0002269_muscular_atrophy0.65364854
124MP0010234_abnormal_vibrissa_follicle0.65125695
125MP0003300_gastrointestinal_ulcer0.64038795
126MP0010030_abnormal_orbit_morphology0.62782189
127MP0006292_abnormal_olfactory_placode0.62356541
128MP0002075_abnormal_coat/hair_pigmentati0.61967476
129MP0001119_abnormal_female_reproductive0.61819234
130MP0006072_abnormal_retinal_apoptosis0.61762402
131MP0001299_abnormal_eye_distance/0.61699963
132MP0005623_abnormal_meninges_morphology0.61508202
133MP0002006_tumorigenesis0.61441597
134MP0005395_other_phenotype0.61367944
135MP0002132_abnormal_respiratory_system0.61308120
136MP0000432_abnormal_head_morphology0.60309133
137MP0003699_abnormal_female_reproductive0.60011738
138MP0003119_abnormal_digestive_system0.59904657
139MP0003861_abnormal_nervous_system0.59535847
140MP0001186_pigmentation_phenotype0.58879589
141MP0000428_abnormal_craniofacial_morphol0.58669613
142MP0005000_abnormal_immune_tolerance0.58410576
143MP0000733_abnormal_muscle_development0.57049119
144MP0009053_abnormal_anal_canal0.56760854
145MP0000537_abnormal_urethra_morphology0.52858450
146MP0005464_abnormal_platelet_physiology0.52296043

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.54212649
2Ependymoma (HP:0002888)3.64173432
3Chromsome breakage (HP:0040012)3.45272068
4Medulloblastoma (HP:0002885)3.44824263
5Reticulocytopenia (HP:0001896)3.37814493
6Selective tooth agenesis (HP:0001592)3.25031188
7Degeneration of anterior horn cells (HP:0002398)3.19982262
8Abnormality of the anterior horn cell (HP:0006802)3.19982262
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.17951681
10Agnosia (HP:0010524)3.17018640
11Colon cancer (HP:0003003)3.13867469
12Basal cell carcinoma (HP:0002671)3.09388945
13Abnormality of chromosome stability (HP:0003220)3.01263110
14Absent thumb (HP:0009777)2.97091409
15Breast hypoplasia (HP:0003187)2.95577244
16Myelodysplasia (HP:0002863)2.91971536
17Patellar aplasia (HP:0006443)2.85777283
18Abnormality of cells of the erythroid lineage (HP:0012130)2.83994785
19Oral leukoplakia (HP:0002745)2.83241253
20Microvesicular hepatic steatosis (HP:0001414)2.77819434
21Amaurosis fugax (HP:0100576)2.77262660
22Thrombocytosis (HP:0001894)2.75119693
23Glossoptosis (HP:0000162)2.72854889
24Nephroblastoma (Wilms tumor) (HP:0002667)2.68896148
25Aplasia/Hypoplasia of the patella (HP:0006498)2.67416770
26IgM deficiency (HP:0002850)2.65719304
27Rhabdomyosarcoma (HP:0002859)2.64136121
28Abnormality of glycolysis (HP:0004366)2.62525757
29Rough bone trabeculation (HP:0100670)2.61737694
30Meckel diverticulum (HP:0002245)2.58810523
31Impulsivity (HP:0100710)2.57146139
32Abnormality of the preputium (HP:0100587)2.56571695
33Atrophy/Degeneration involving motor neurons (HP:0007373)2.55410132
34Embryonal renal neoplasm (HP:0011794)2.52368328
35Deviation of the thumb (HP:0009603)2.52160794
36Abnormal number of erythroid precursors (HP:0012131)2.52043018
37Proximal placement of thumb (HP:0009623)2.51375124
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46642283
39Abnormality of alanine metabolism (HP:0010916)2.46642283
40Hyperalaninemia (HP:0003348)2.46642283
41Carpal bone hypoplasia (HP:0001498)2.44984814
42Abnormality of the ileum (HP:0001549)2.44974872
43Abnormality of the astrocytes (HP:0100707)2.41213205
44Astrocytoma (HP:0009592)2.41213205
45Abnormality of methionine metabolism (HP:0010901)2.38356003
46Entropion (HP:0000621)2.38199864
47Multiple enchondromatosis (HP:0005701)2.37877899
48Aplastic anemia (HP:0001915)2.36887072
49Abnormality of the labia minora (HP:0012880)2.35164311
50Cutaneous melanoma (HP:0012056)2.34724569
51Increased serum pyruvate (HP:0003542)2.34480758
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.30493605
53Glioma (HP:0009733)2.29294363
54Neoplasm of the pancreas (HP:0002894)2.28939615
55Squamous cell carcinoma (HP:0002860)2.26958794
56Lymphoma (HP:0002665)2.26866249
57Abnormal number of incisors (HP:0011064)2.25949492
58Trismus (HP:0000211)2.25324009
59Bone marrow hypocellularity (HP:0005528)2.24446214
60Progressive muscle weakness (HP:0003323)2.24252962
6111 pairs of ribs (HP:0000878)2.23012688
62Aplasia/Hypoplasia of the sternum (HP:0006714)2.20586801
63Prominent nose (HP:0000448)2.17175825
64Ankle contracture (HP:0006466)2.17026381
65Premature graying of hair (HP:0002216)2.15836319
66Duodenal stenosis (HP:0100867)2.14090820
67Small intestinal stenosis (HP:0012848)2.14090820
68Absent radius (HP:0003974)2.13799122
69Spinal muscular atrophy (HP:0007269)2.12650995
70Sloping forehead (HP:0000340)2.11125593
71Volvulus (HP:0002580)2.09766351
72Cafe-au-lait spot (HP:0000957)2.08448888
73Pallor (HP:0000980)2.07098245
74Increased nuchal translucency (HP:0010880)2.05943063
75Biliary tract neoplasm (HP:0100574)2.04970329
76Atresia of the external auditory canal (HP:0000413)2.04889498
77Neoplasm of striated muscle (HP:0009728)2.03418938
78Cellular immunodeficiency (HP:0005374)2.01292919
79Facial cleft (HP:0002006)2.00403013
80Macrocytic anemia (HP:0001972)2.00402633
81Ectopic kidney (HP:0000086)1.99303319
82Clubbing of toes (HP:0100760)1.98527404
83Choanal atresia (HP:0000453)1.97388251
84Absent forearm bone (HP:0003953)1.96591441
85Aplasia involving forearm bones (HP:0009822)1.96591441
86Acute myeloid leukemia (HP:0004808)1.94837875
87Abnormality of the distal phalanges of the toes (HP:0010182)1.94558964
88Progressive external ophthalmoplegia (HP:0000590)1.94403935
89Tracheoesophageal fistula (HP:0002575)1.91850087
90Neoplasm of the oral cavity (HP:0100649)1.90705123
91Duplicated collecting system (HP:0000081)1.89201730
92Cerebral hypomyelination (HP:0006808)1.89074880
93Type I transferrin isoform profile (HP:0003642)1.89070820
94Neoplasm of the adrenal gland (HP:0100631)1.88509674
95Horseshoe kidney (HP:0000085)1.87948734
96Secondary amenorrhea (HP:0000869)1.87627615
97Pelvic girdle muscle weakness (HP:0003749)1.86794284
98Freckling (HP:0001480)1.86301170
99Abnormality of DNA repair (HP:0003254)1.86038020
100Cortical dysplasia (HP:0002539)1.85874870
101T lymphocytopenia (HP:0005403)1.85859211
102Homocystinuria (HP:0002156)1.84500270
103Abnormality of homocysteine metabolism (HP:0010919)1.84500270
104Poikiloderma (HP:0001029)1.84325043
105Neoplasm of the adrenal cortex (HP:0100641)1.83775621
106Abnormal trabecular bone morphology (HP:0100671)1.82768202
107Missing ribs (HP:0000921)1.82467900
108Amyotrophic lateral sclerosis (HP:0007354)1.80679012
109Abnormality of the carotid arteries (HP:0005344)1.80068242
110Abnormality of the pons (HP:0007361)1.79328724
111Abnormality of the calcaneus (HP:0008364)1.79073982
112Sensory axonal neuropathy (HP:0003390)1.78827481
113Abnormal lung lobation (HP:0002101)1.78444372
114Abnormality of the duodenum (HP:0002246)1.76123789
115Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76011654
116Abnormal protein N-linked glycosylation (HP:0012347)1.76011654
117Abnormal protein glycosylation (HP:0012346)1.76011654
118Abnormal glycosylation (HP:0012345)1.76011654
119Neoplasm of the colon (HP:0100273)1.75753981
120Overlapping toe (HP:0001845)1.75714210
121Megaloblastic anemia (HP:0001889)1.75363236
122Hypoplasia of the pons (HP:0012110)1.74890261
123Reduced antithrombin III activity (HP:0001976)1.74778625
124Short thumb (HP:0009778)1.74285342
125Spastic diplegia (HP:0001264)1.74268067
126Short 4th metacarpal (HP:0010044)1.72901658
127Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.72901658
128Facial hemangioma (HP:0000329)1.72630715
129Microglossia (HP:0000171)1.72514364
130Postnatal microcephaly (HP:0005484)1.71578200
131Ureteral duplication (HP:0000073)1.71545056
132Neoplasm of the small intestine (HP:0100833)1.71484057
133Premature ovarian failure (HP:0008209)1.71238406
134Abnormality of pyrimidine metabolism (HP:0004353)1.71160744
135Cleft eyelid (HP:0000625)1.70926392
136Triphalangeal thumb (HP:0001199)1.70524727
137Microretrognathia (HP:0000308)1.69840806
138Septate vagina (HP:0001153)1.68300751
139Increased serum lactate (HP:0002151)1.64069289
140Deep philtrum (HP:0002002)1.63983820
141Pancytopenia (HP:0001876)1.63538580
142Asymmetry of the thorax (HP:0001555)1.63446360
143Meningioma (HP:0002858)1.61807181
144Arteriovenous malformation (HP:0100026)1.60570060
145Neoplasm of the peripheral nervous system (HP:0100007)1.60167652
146Hypobetalipoproteinemia (HP:0003563)1.58723692
147Abnormality of chromosome segregation (HP:0002916)1.58547265
148Pancreatic islet-cell hyperplasia (HP:0004510)1.58131002
149Dysmetric saccades (HP:0000641)1.57210354
150Hypoplasia of the capital femoral epiphysis (HP:0003090)1.56543476
151Embryonal neoplasm (HP:0002898)1.55179694

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.90313924
2BUB13.86830019
3WEE13.77400174
4TSSK62.96517650
5SRPK12.59692607
6NEK22.52714806
7EIF2AK12.45784409
8EEF2K2.29451989
9ACVR1B2.23308187
10TTK2.11983898
11CDK122.11396578
12RPS6KB22.04092069
13PASK1.95261910
14BRSK21.94384775
15VRK21.81142103
16PKN21.76314249
17PLK11.75687850
18NEK11.75574021
19RPS6KA41.74766391
20MKNK11.72763387
21PLK31.69938051
22EIF2AK31.68057037
23ATR1.67688203
24MAP4K11.65570336
25PLK41.65119652
26STK101.61424222
27AURKB1.60463699
28EPHA21.54641451
29NME21.54381464
30MAP3K101.51878455
31MST1R1.48396990
32TAF11.46997621
33MKNK21.44681617
34CDK71.43091773
35LATS11.41129940
36CHEK11.38134921
37VRK11.36945414
38MAP3K81.36582793
39CDK41.36300726
40ALK1.35602864
41PDK21.34886431
42SMG11.29638974
43SCYL21.28590232
44FLT31.26155517
45DYRK31.25063314
46PIM11.23623621
47NUAK11.22355355
48TRIM281.19465283
49CHEK21.17760072
50TGFBR11.16836788
51MET1.14382202
52BMPR1B1.10119369
53PAK41.08275004
54TESK21.07007685
55NME11.06790094
56ZAK1.05241656
57TLK11.01647130
58STK38L1.00984872
59STK40.98876314
60ATM0.98167214
61BRSK10.94585525
62ERBB40.94109574
63BRD40.93506388
64CDK60.92716276
65CDK20.91823847
66MAP2K30.91081023
67STK30.87461906
68LRRK20.83637569
69AURKA0.82284833
70ERBB30.80281492
71JAK30.79629199
72PIM20.78177568
73LATS20.77341189
74CSNK2A20.76466889
75ZAP700.72907244
76CDK80.68655094
77TXK0.68316520
78BTK0.68187482
79STK390.65604936
80NEK90.64809405
81CDK10.64274702
82GRK60.64069093
83CSF1R0.63976171
84MST40.63319950
85MTOR0.62582267
86TRIB30.59637242
87MELK0.59448577
88BCR0.57963232
89RAF10.56104329
90CSNK2A10.55620333
91CAMK1G0.54697814
92AKT20.53828973
93MARK30.52926667
94TTN0.52677746
95IRAK30.52587938
96PIK3CG0.52386114
97IKBKB0.52232687
98STK160.51489914
99WNK40.51249806
100CSNK1G10.50641558
101NEK60.50591688
102AKT30.49327043
103FRK0.48379370
104PRKCI0.46783447
105PAK20.46683632
106CSNK1A1L0.46205244
107CDK90.45887915
108CCNB10.45085007
109PAK10.44153680
110MAP3K30.43687651
111PLK20.43467938
112TEC0.43319131
113CSNK1E0.43023557
114RPS6KA50.41551430
115CSNK1G30.41396071
116BRAF0.41098078
117CHUK0.40423700
118PRKDC0.40186258
119CAMK1D0.39717817
120RPS6KB10.39523210
121EIF2AK20.38705688
122STK240.37962820
123INSRR0.35947126
124LCK0.35588909
125ICK0.34090851
126PBK0.33848783
127CLK10.33232813
128CSNK1D0.32630049
129CDK30.32044059
130PNCK0.31954221
131MAPKAPK30.31914106
132MAPKAPK50.31691534
133TYK20.31351039
134MAPK140.30990215
135TNIK0.30853409
136FGFR10.29894938
137ILK0.28663919

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.34348651
2* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.26999578
3Mismatch repair_Homo sapiens_hsa034303.88081442
4RNA transport_Homo sapiens_hsa030133.37654659
5Spliceosome_Homo sapiens_hsa030403.28546324
6One carbon pool by folate_Homo sapiens_hsa006703.02949336
7RNA polymerase_Homo sapiens_hsa030202.93523684
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.87396962
9Base excision repair_Homo sapiens_hsa034102.76100943
10Nucleotide excision repair_Homo sapiens_hsa034202.69654555
11Proteasome_Homo sapiens_hsa030502.69609029
12Homologous recombination_Homo sapiens_hsa034402.63732317
13Cell cycle_Homo sapiens_hsa041102.62329516
14Ribosome_Homo sapiens_hsa030102.57583692
15Non-homologous end-joining_Homo sapiens_hsa034502.10044265
16Pyrimidine metabolism_Homo sapiens_hsa002402.05654962
17Fanconi anemia pathway_Homo sapiens_hsa034601.96614695
18RNA degradation_Homo sapiens_hsa030181.88311332
19mRNA surveillance pathway_Homo sapiens_hsa030151.86128062
20Basal transcription factors_Homo sapiens_hsa030221.79207408
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.76635517
22p53 signaling pathway_Homo sapiens_hsa041151.59909531
23Protein export_Homo sapiens_hsa030601.50344925
24Epstein-Barr virus infection_Homo sapiens_hsa051691.41922988
25Systemic lupus erythematosus_Homo sapiens_hsa053221.41195340
26Pyruvate metabolism_Homo sapiens_hsa006201.36748461
27Antigen processing and presentation_Homo sapiens_hsa046121.36012710
28Viral carcinogenesis_Homo sapiens_hsa052031.28229274
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24350575
30Propanoate metabolism_Homo sapiens_hsa006401.18671249
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16264214
32Herpes simplex infection_Homo sapiens_hsa051681.12764617
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08355669
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06114425
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05127932
36Purine metabolism_Homo sapiens_hsa002301.03911829
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97518898
38Selenocompound metabolism_Homo sapiens_hsa004500.96738492
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93168414
40Legionellosis_Homo sapiens_hsa051340.92791062
41Primary immunodeficiency_Homo sapiens_hsa053400.91650350
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90938317
43HTLV-I infection_Homo sapiens_hsa051660.89843814
44Steroid biosynthesis_Homo sapiens_hsa001000.88471930
45Biosynthesis of amino acids_Homo sapiens_hsa012300.87732449
46Pentose phosphate pathway_Homo sapiens_hsa000300.86617025
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.86270367
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84234755
49N-Glycan biosynthesis_Homo sapiens_hsa005100.83705528
50Small cell lung cancer_Homo sapiens_hsa052220.81780618
51Vitamin B6 metabolism_Homo sapiens_hsa007500.81682429
52NF-kappa B signaling pathway_Homo sapiens_hsa040640.80152550
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.78393973
54Measles_Homo sapiens_hsa051620.78274812
55Oocyte meiosis_Homo sapiens_hsa041140.76127177
56MicroRNAs in cancer_Homo sapiens_hsa052060.76051774
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.72333813
58Thyroid cancer_Homo sapiens_hsa052160.71810029
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71066623
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68338795
61Fatty acid elongation_Homo sapiens_hsa000620.67824725
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67253628
63Apoptosis_Homo sapiens_hsa042100.65272693
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65113915
65Chronic myeloid leukemia_Homo sapiens_hsa052200.62080893
66Hepatitis B_Homo sapiens_hsa051610.57964608
67Acute myeloid leukemia_Homo sapiens_hsa052210.55145787
68mTOR signaling pathway_Homo sapiens_hsa041500.55039455
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.51882712
70Influenza A_Homo sapiens_hsa051640.51130959
71Fatty acid biosynthesis_Homo sapiens_hsa000610.50684439
72Colorectal cancer_Homo sapiens_hsa052100.50393060
73B cell receptor signaling pathway_Homo sapiens_hsa046620.50231836
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48832956
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48173900
76Shigellosis_Homo sapiens_hsa051310.47803409
77Glutathione metabolism_Homo sapiens_hsa004800.47667534
78Arginine and proline metabolism_Homo sapiens_hsa003300.46834101
79Metabolic pathways_Homo sapiens_hsa011000.45987079
80Fatty acid metabolism_Homo sapiens_hsa012120.45690591
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44947723
82HIF-1 signaling pathway_Homo sapiens_hsa040660.44930867
83T cell receptor signaling pathway_Homo sapiens_hsa046600.44923051
84Huntingtons disease_Homo sapiens_hsa050160.44710266
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43834266
86Hematopoietic cell lineage_Homo sapiens_hsa046400.42975818
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42144429
88Sulfur metabolism_Homo sapiens_hsa009200.41124497
89Carbon metabolism_Homo sapiens_hsa012000.40935539
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39906826
91Sulfur relay system_Homo sapiens_hsa041220.39518341
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39245827
93Viral myocarditis_Homo sapiens_hsa054160.38511123
94Leishmaniasis_Homo sapiens_hsa051400.37570713
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37566826
96Alcoholism_Homo sapiens_hsa050340.37456330
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36440397
98Butanoate metabolism_Homo sapiens_hsa006500.36306218
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.33872881
100TGF-beta signaling pathway_Homo sapiens_hsa043500.33688365
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33475580
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32321527
103Arginine biosynthesis_Homo sapiens_hsa002200.31728714
104Folate biosynthesis_Homo sapiens_hsa007900.31150956
105Non-small cell lung cancer_Homo sapiens_hsa052230.29793730
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.29703428
107Prostate cancer_Homo sapiens_hsa052150.29413414
108Toxoplasmosis_Homo sapiens_hsa051450.29095599
109Melanoma_Homo sapiens_hsa052180.28692834
110Bladder cancer_Homo sapiens_hsa052190.28562440
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28486309
1122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27624916
113Allograft rejection_Homo sapiens_hsa053300.26804464
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25479427
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.24663324
116Basal cell carcinoma_Homo sapiens_hsa052170.24447951
117Hedgehog signaling pathway_Homo sapiens_hsa043400.24184753
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23801184
119Adherens junction_Homo sapiens_hsa045200.23623552
120Fructose and mannose metabolism_Homo sapiens_hsa000510.23615309
121beta-Alanine metabolism_Homo sapiens_hsa004100.22902687
122Lysine degradation_Homo sapiens_hsa003100.22504671
123Pathways in cancer_Homo sapiens_hsa052000.22314851
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.22245642
125Pancreatic cancer_Homo sapiens_hsa052120.21373350
126Hippo signaling pathway_Homo sapiens_hsa043900.20976291
127Wnt signaling pathway_Homo sapiens_hsa043100.20939391
128Parkinsons disease_Homo sapiens_hsa050120.20629966
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20619757
130Notch signaling pathway_Homo sapiens_hsa043300.20610575
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20268699
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18572807
133Vitamin digestion and absorption_Homo sapiens_hsa049770.18485913
134FoxO signaling pathway_Homo sapiens_hsa040680.18234200
135Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.17505828
136Proteoglycans in cancer_Homo sapiens_hsa052050.17023726
137Osteoclast differentiation_Homo sapiens_hsa043800.16964208
138Peroxisome_Homo sapiens_hsa041460.16697133
139Tight junction_Homo sapiens_hsa045300.13140562
140Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.11730241

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