WDR31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1replicative senescence (GO:0090399)7.92849965
2hematopoietic stem cell proliferation (GO:0071425)7.64628781
3positive regulation of prostaglandin secretion (GO:0032308)6.67391670
4melanin biosynthetic process (GO:0042438)6.38854212
5melanin metabolic process (GO:0006582)6.18381510
6regulation of somitogenesis (GO:0014807)5.79156272
7regulation of prostaglandin secretion (GO:0032306)5.70754602
8secondary metabolite biosynthetic process (GO:0044550)5.60122424
9detection of calcium ion (GO:0005513)5.56252373
10negative regulation of catenin import into nucleus (GO:0035414)5.55778867
11regulation of endothelial cell differentiation (GO:0045601)5.46972547
12response to pheromone (GO:0019236)5.46544218
13microtubule depolymerization (GO:0007019)4.95714722
14neuronal action potential (GO:0019228)4.77422796
15positive regulation of fatty acid transport (GO:2000193)4.76079912
16positive regulation of icosanoid secretion (GO:0032305)4.70496340
17developmental pigmentation (GO:0048066)4.62695309
18primary amino compound metabolic process (GO:1901160)4.57723975
19water-soluble vitamin biosynthetic process (GO:0042364)4.44728071
20DNA replication-dependent nucleosome organization (GO:0034723)4.34940522
21DNA replication-dependent nucleosome assembly (GO:0006335)4.34940522
22behavioral response to nicotine (GO:0035095)4.24872301
23tryptophan metabolic process (GO:0006568)4.16113757
24tryptophan catabolic process (GO:0006569)4.12957939
25indole-containing compound catabolic process (GO:0042436)4.12957939
26indolalkylamine catabolic process (GO:0046218)4.12957939
27indolalkylamine metabolic process (GO:0006586)4.11361292
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.08065284
29mitochondrial respiratory chain complex I assembly (GO:0032981)4.08065284
30NADH dehydrogenase complex assembly (GO:0010257)4.08065284
31startle response (GO:0001964)3.94223901
32axonemal dynein complex assembly (GO:0070286)3.92731189
33cellular response to cholesterol (GO:0071397)3.78830388
34righting reflex (GO:0060013)3.77883161
35presynaptic membrane assembly (GO:0097105)3.76571403
36epithelial cilium movement (GO:0003351)3.73186435
37transcription elongation from RNA polymerase III promoter (GO:0006385)3.72959134
38termination of RNA polymerase III transcription (GO:0006386)3.72959134
39regulation of short-term neuronal synaptic plasticity (GO:0048172)3.72658894
40cilium movement (GO:0003341)3.68806838
41cilium or flagellum-dependent cell motility (GO:0001539)3.67597994
42serotonin metabolic process (GO:0042428)3.63895801
43G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.58015713
44white fat cell differentiation (GO:0050872)3.53153212
45kynurenine metabolic process (GO:0070189)3.50872744
46neuron cell-cell adhesion (GO:0007158)3.50198590
47motile cilium assembly (GO:0044458)3.46821940
48glutamate receptor signaling pathway (GO:0007215)3.41244957
49preassembly of GPI anchor in ER membrane (GO:0016254)3.40047879
50photoreceptor cell maintenance (GO:0045494)3.39406344
51indole-containing compound metabolic process (GO:0042430)3.38975158
52regulation of icosanoid secretion (GO:0032303)3.38133613
53epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.38129696
54cellular response to sterol (GO:0036315)3.36737075
55presynaptic membrane organization (GO:0097090)3.35339154
56ionotropic glutamate receptor signaling pathway (GO:0035235)3.32544192
57gamma-aminobutyric acid signaling pathway (GO:0007214)3.30511749
58protein complex biogenesis (GO:0070271)3.26897040
59regulation of rhodopsin mediated signaling pathway (GO:0022400)3.26088036
60negative regulation of synaptic transmission, GABAergic (GO:0032229)3.24585091
61retinal cone cell development (GO:0046549)3.21565404
62acrosome reaction (GO:0007340)3.21020256
63L-fucose catabolic process (GO:0042355)3.20064520
64fucose catabolic process (GO:0019317)3.20064520
65L-fucose metabolic process (GO:0042354)3.20064520
66rhodopsin mediated signaling pathway (GO:0016056)3.18935216
67mitochondrial respiratory chain complex assembly (GO:0033108)3.12426553
68microtubule polymerization or depolymerization (GO:0031109)3.11862477
69positive regulation of organic acid transport (GO:0032892)3.10307742
70postsynaptic membrane organization (GO:0001941)3.09021052
71detection of light stimulus involved in sensory perception (GO:0050962)3.08801850
72detection of light stimulus involved in visual perception (GO:0050908)3.08801850
73sulfation (GO:0051923)3.00267614
74intraciliary transport (GO:0042073)2.99787075
75amine catabolic process (GO:0009310)2.99325952
76cellular biogenic amine catabolic process (GO:0042402)2.99325952
77nonmotile primary cilium assembly (GO:0035058)2.98362263
78regulation of hippo signaling (GO:0035330)2.97489393
79cilium assembly (GO:0042384)2.97435751
80somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95047602
81somatic hypermutation of immunoglobulin genes (GO:0016446)2.95047602
82axoneme assembly (GO:0035082)2.94254755
83cilium organization (GO:0044782)2.93473193
84negative regulation of DNA-dependent DNA replication (GO:2000104)2.92303193
85energy coupled proton transport, down electrochemical gradient (GO:0015985)2.92236837
86ATP synthesis coupled proton transport (GO:0015986)2.92236837
87histone H2B ubiquitination (GO:0033523)2.91666804
88protein localization to synapse (GO:0035418)2.85862070
89keratinocyte development (GO:0003334)2.85435771
90eye photoreceptor cell development (GO:0042462)2.81532940
91protein localization to cilium (GO:0061512)2.79076585
92neuron-neuron synaptic transmission (GO:0007270)2.77776448
93cysteine metabolic process (GO:0006534)2.76967994
94C4-dicarboxylate transport (GO:0015740)2.73497470
95retinal rod cell development (GO:0046548)2.72199417
96action potential (GO:0001508)2.69665664
97photoreceptor cell development (GO:0042461)2.69030356
98polyketide metabolic process (GO:0030638)2.67272078
99doxorubicin metabolic process (GO:0044598)2.67272078
100daunorubicin metabolic process (GO:0044597)2.67272078
101G-protein coupled receptor internalization (GO:0002031)2.67092418
102phenol-containing compound biosynthetic process (GO:0046189)2.66876863
103DNA deamination (GO:0045006)2.66393348
104synaptic transmission, glutamatergic (GO:0035249)2.66100757
105L-methionine biosynthetic process (GO:0071265)2.65108810
106amino acid salvage (GO:0043102)2.65108810
107L-methionine salvage (GO:0071267)2.65108810
108mitochondrial calcium ion transport (GO:0006851)2.64337545
109negative regulation of epithelial to mesenchymal transition (GO:0010719)2.64028519
110regulation of feeding behavior (GO:0060259)2.63873912
111glycerophospholipid catabolic process (GO:0046475)2.63670636
112regulation of pigment cell differentiation (GO:0050932)2.62875829
113left/right axis specification (GO:0070986)2.62803721
114purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.60536100
1153-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.60536100
116piRNA metabolic process (GO:0034587)2.58954599
117centriole assembly (GO:0098534)2.58457403
118L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.58410619
119regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.56517463
120establishment of protein localization to mitochondrial membrane (GO:0090151)2.56129967
121GPI anchor biosynthetic process (GO:0006506)2.55781443
122response to nitrosative stress (GO:0051409)2.55667154
123serotonin receptor signaling pathway (GO:0007210)2.55026887
124centriole replication (GO:0007099)2.54949917
125negative regulation of mast cell activation (GO:0033004)2.53547133
126primary alcohol catabolic process (GO:0034310)2.53468467
127protein polyglutamylation (GO:0018095)2.53379651
128ventricular system development (GO:0021591)2.52569654
129regulation of germinal center formation (GO:0002634)2.50960777
130rRNA catabolic process (GO:0016075)2.49964211
131DNA methylation involved in gamete generation (GO:0043046)2.49748061
132aromatic amino acid family catabolic process (GO:0009074)2.49385536
133negative regulation of systemic arterial blood pressure (GO:0003085)2.48848901
134adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)2.47424819
135positive regulation of mRNA 3-end processing (GO:0031442)2.45578682
136regulation of excitatory postsynaptic membrane potential (GO:0060079)2.45307964
137regulation of timing of cell differentiation (GO:0048505)2.44627461
138positive regulation of fatty acid biosynthetic process (GO:0045723)2.43757728
139regulation of DNA endoreduplication (GO:0032875)2.42993353
140pigmentation (GO:0043473)2.42224004
141inner ear receptor stereocilium organization (GO:0060122)2.42055773
142regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.42014267
143auditory receptor cell stereocilium organization (GO:0060088)2.41805024
144arginine metabolic process (GO:0006525)2.41530975
145nephron epithelium morphogenesis (GO:0072088)2.41522958
146nephron tubule morphogenesis (GO:0072078)2.41522958
147regulation of mRNA 3-end processing (GO:0031440)2.40989881
148GPI anchor metabolic process (GO:0006505)2.40557104
149positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.40218155
150positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.39697395
151cellular biogenic amine biosynthetic process (GO:0042401)2.39174160
152neuronal action potential propagation (GO:0019227)2.38727896
153macroautophagy (GO:0016236)2.38436694
154retina layer formation (GO:0010842)2.38248151
155cellular ketone body metabolic process (GO:0046950)2.37827895
156gamma-aminobutyric acid transport (GO:0015812)2.37770338
157regulation of postsynaptic membrane potential (GO:0060078)2.37474672
158regulation of memory T cell differentiation (GO:0043380)2.36950658
159reflex (GO:0060004)2.36941753
160aminoglycoside antibiotic metabolic process (GO:0030647)2.36766474
161organic cation transport (GO:0015695)2.35566317
162positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.35498106
163DNA integration (GO:0015074)2.34915778
164neuron recognition (GO:0008038)2.31674529
165long-chain fatty acid biosynthetic process (GO:0042759)2.31304095
166cornea development in camera-type eye (GO:0061303)2.29428012
167negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.28820720
168negative regulation of translation, ncRNA-mediated (GO:0040033)2.28820720
169regulation of translation, ncRNA-mediated (GO:0045974)2.28820720
170C-terminal protein amino acid modification (GO:0018410)2.28794602
171GTP biosynthetic process (GO:0006183)2.28428508
172cerebral cortex radially oriented cell migration (GO:0021799)2.28059090
173histone H3-K4 trimethylation (GO:0080182)2.26930357
174cellular response to ATP (GO:0071318)2.25620783
175behavioral response to ethanol (GO:0048149)2.25262120
176positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.24916415
177melanocyte differentiation (GO:0030318)2.24765699
178cell morphogenesis involved in neuron differentiation (GO:0048667)2.24677232
179negative regulation of execution phase of apoptosis (GO:1900118)2.23961359
180regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.23204257
181response to X-ray (GO:0010165)2.23126311
182detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.23023111
183positive regulation of protein sumoylation (GO:0033235)2.22974690
184transmission of nerve impulse (GO:0019226)2.21696353
185urinary tract smooth muscle contraction (GO:0014848)2.21362352
186positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.20605978

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.14093929
2EZH2_22144423_ChIP-Seq_EOC_Human3.85222296
3ZNF274_21170338_ChIP-Seq_K562_Hela3.41166629
4PCGF2_27294783_Chip-Seq_ESCs_Mouse2.98703558
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.90877073
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.73318168
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.73301288
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.43277299
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.41655506
10PCGF2_27294783_Chip-Seq_NPCs_Mouse2.39985241
11TAF15_26573619_Chip-Seq_HEK293_Human2.36514336
12SUZ12_27294783_Chip-Seq_NPCs_Mouse2.36477002
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.33802224
14NFE2_27457419_Chip-Seq_LIVER_Mouse2.27625937
15BMI1_23680149_ChIP-Seq_NPCS_Mouse2.11511628
16IGF1R_20145208_ChIP-Seq_DFB_Human2.10220661
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.06123305
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01039672
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse11.5911823
20FUS_26573619_Chip-Seq_HEK293_Human1.97532125
21VDR_22108803_ChIP-Seq_LS180_Human1.95942973
22EGR1_23403033_ChIP-Seq_LIVER_Mouse1.95832779
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.95484620
24TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.93769976
25NANOG_18555785_Chip-Seq_ESCs_Mouse1.93343713
26EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.92113114
27EZH2_27294783_Chip-Seq_NPCs_Mouse1.90154222
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89464743
29P300_19829295_ChIP-Seq_ESCs_Human1.88315701
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86665340
31* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84778969
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84349917
33SUZ12_18555785_Chip-Seq_ESCs_Mouse1.83051300
34P53_22387025_ChIP-Seq_ESCs_Mouse1.81989364
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.79296790
36E2F1_18555785_Chip-Seq_ESCs_Mouse1.78990076
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.78442280
38EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.75161364
39STAT3_18555785_Chip-Seq_ESCs_Mouse1.69974852
40P300_18555785_Chip-Seq_ESCs_Mouse1.69148449
41CMYC_18555785_Chip-Seq_ESCs_Mouse1.67153110
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64866047
43NMYC_18555785_Chip-Seq_ESCs_Mouse1.64474800
44RUNX1_27457419_Chip-Seq_LIVER_Mouse1.64149872
45SMAD4_21799915_ChIP-Seq_A2780_Human1.63455710
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62912932
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61279279
48RNF2_27304074_Chip-Seq_NSC_Mouse1.56731276
49OCT4_18555785_Chip-Seq_ESCs_Mouse1.55617974
50SOX2_18555785_Chip-Seq_ESCs_Mouse1.52908399
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.52223509
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51848811
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.49489437
54EWS_26573619_Chip-Seq_HEK293_Human1.49425112
55CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48786385
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.48452694
57TP53_16413492_ChIP-PET_HCT116_Human1.47014990
58KLF4_18555785_Chip-Seq_ESCs_Mouse1.46754884
59* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45859686
60ER_23166858_ChIP-Seq_MCF-7_Human1.45778155
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45734778
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45734778
63ZFX_18555785_Chip-Seq_ESCs_Mouse1.44905550
64REST_21632747_ChIP-Seq_MESCs_Mouse1.44868353
65PU1_27457419_Chip-Seq_LIVER_Mouse1.42864364
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42328446
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.42036028
68TAL1_26923725_Chip-Seq_HPCs_Mouse1.41258444
69EED_16625203_ChIP-ChIP_MESCs_Mouse1.40925365
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39906419
71CRX_20693478_ChIP-Seq_RETINA_Mouse1.39568680
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39051115
73SMAD1_18555785_Chip-Seq_ESCs_Mouse1.38573995
74ESRRB_18555785_Chip-Seq_ESCs_Mouse1.37865567
75CTCF_18555785_Chip-Seq_ESCs_Mouse1.37549333
76OCT4_21477851_ChIP-Seq_ESCs_Mouse1.37107339
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.35534408
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34992282
79STAT3_23295773_ChIP-Seq_U87_Human1.33591610
80CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33286843
81MYC_18940864_ChIP-ChIP_HL60_Human1.27840573
82SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27352443
83SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.27148372
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25579016
85SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24939272
86TCF4_23295773_ChIP-Seq_U87_Human1.24057575
87* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22729618
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.21661999
89BCAT_22108803_ChIP-Seq_LS180_Human1.21542697
90RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19687509
91SMAD_19615063_ChIP-ChIP_OVARY_Human1.18939557
92* TP53_22573176_ChIP-Seq_HFKS_Human1.18187509
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17150016
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15527629
95SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15401213
96EZH2_27294783_Chip-Seq_ESCs_Mouse1.14373572
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14142534
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13754699
99AR_21572438_ChIP-Seq_LNCaP_Human1.12003937
100RUNX2_22187159_ChIP-Seq_PCA_Human1.11589877
101GABP_17652178_ChIP-ChIP_JURKAT_Human1.11187875
102KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10587176
103KDM2B_26808549_Chip-Seq_REH_Human1.10158830
104* AR_25329375_ChIP-Seq_VCAP_Human1.09582835
105JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08487812
106RNF2_27304074_Chip-Seq_ESCs_Mouse1.08293220
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07486262
108IRF1_19129219_ChIP-ChIP_H3396_Human1.07218462
109RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04781387
110FLI1_21867929_ChIP-Seq_TH2_Mouse1.03669819
111LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03012513
112POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02708625
113SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02587271
114SALL1_21062744_ChIP-ChIP_HESCs_Human1.01720508
115TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01571641
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01152549
117SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00741681
118PRDM14_20953172_ChIP-Seq_ESCs_Human1.00723680
119FOXA1_25329375_ChIP-Seq_VCAP_Human1.00126891
120FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00126891
121FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99873352
122ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99072517
123HOXB7_26014856_ChIP-Seq_BT474_Human0.98371074
124NANOG_19829295_ChIP-Seq_ESCs_Human0.96826479
125SOX2_19829295_ChIP-Seq_ESCs_Human0.96826479
126IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96771130
127CBP_20019798_ChIP-Seq_JUKART_Human0.96771130
128FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94501157
129GATA3_21878914_ChIP-Seq_MCF-7_Human0.92107258
130TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91503427
131KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89080549
132SMAD4_21741376_ChIP-Seq_EPCs_Human0.88940626
133TCF4_22108803_ChIP-Seq_LS180_Human0.87413186
134REST_18959480_ChIP-ChIP_MESCs_Mouse0.87319969
135AR_20517297_ChIP-Seq_VCAP_Human0.84037253
136EST1_17652178_ChIP-ChIP_JURKAT_Human0.83849193
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81020928
138ERA_21632823_ChIP-Seq_H3396_Human0.80002696
139SOX2_16153702_ChIP-ChIP_HESCs_Human0.79967721
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79849633
141ELK1_19687146_ChIP-ChIP_HELA_Human0.79549383
142VDR_23849224_ChIP-Seq_CD4+_Human0.76531471
143GATA1_26923725_Chip-Seq_HPCs_Mouse0.76411292
144LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74928865
145MYC_19829295_ChIP-Seq_ESCs_Human0.74476203
146EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.74446996
147GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.74157183

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation4.03328550
2MP0008872_abnormal_physiological_respon3.98016434
3MP0000372_irregular_coat_pigmentation3.87028928
4MP0001188_hyperpigmentation3.84078813
5MP0003136_yellow_coat_color3.82231488
6MP0003195_calcinosis3.76887023
7MP0003880_abnormal_central_pattern3.29649570
8MP0006292_abnormal_olfactory_placode3.24271165
9MP0002102_abnormal_ear_morphology3.06784089
10MP0009764_decreased_sensitivity_to3.02340373
11MP0004381_abnormal_hair_follicle2.93060672
12MP0000015_abnormal_ear_pigmentation2.87094539
13MP0005409_darkened_coat_color2.52714260
14MP0008875_abnormal_xenobiotic_pharmacok2.44923962
15MP0005551_abnormal_eye_electrophysiolog2.37083415
16MP0002638_abnormal_pupillary_reflex2.19765638
17MP0005084_abnormal_gallbladder_morpholo2.10361819
18MP0005174_abnormal_tail_pigmentation2.08680865
19MP0003646_muscle_fatigue2.06308441
20MP0009046_muscle_twitch2.04774698
21MP0002837_dystrophic_cardiac_calcinosis2.03118596
22MP0002095_abnormal_skin_pigmentation2.02318534
23MP0001986_abnormal_taste_sensitivity1.94455644
24MP0003787_abnormal_imprinting1.94385289
25MP0006072_abnormal_retinal_apoptosis1.89577707
26MP0008877_abnormal_DNA_methylation1.86860254
27MP0005423_abnormal_somatic_nervous1.85557417
28MP0003252_abnormal_bile_duct1.83747897
29MP0005085_abnormal_gallbladder_physiolo1.83265627
30MP0003011_delayed_dark_adaptation1.78231852
31MP0001486_abnormal_startle_reflex1.77380893
32MP0000569_abnormal_digit_pigmentation1.76289438
33MP0005253_abnormal_eye_physiology1.75704695
34MP0009745_abnormal_behavioral_response1.71408657
35MP0002735_abnormal_chemical_nociception1.70124734
36MP0005075_abnormal_melanosome_morpholog1.68495980
37MP0001968_abnormal_touch/_nociception1.68167084
38MP0008058_abnormal_DNA_repair1.64775501
39MP0003122_maternal_imprinting1.64349903
40MP0005410_abnormal_fertilization1.64301774
41MP0004133_heterotaxia1.63523612
42MP0002736_abnormal_nociception_after1.62468390
43MP0004142_abnormal_muscle_tone1.59368583
44MP0002272_abnormal_nervous_system1.58588631
45MP0003635_abnormal_synaptic_transmissio1.57554542
46MP0002653_abnormal_ependyma_morphology1.56702238
47MP0004147_increased_porphyrin_level1.55540246
48MP0005645_abnormal_hypothalamus_physiol1.53839451
49MP0002928_abnormal_bile_duct1.50557167
50MP0004859_abnormal_synaptic_plasticity1.49028941
51MP0002067_abnormal_sensory_capabilities1.44129743
52MP0002572_abnormal_emotion/affect_behav1.42477508
53MP0004270_analgesia1.42154862
54MP0001529_abnormal_vocalization1.39652317
55MP0000427_abnormal_hair_cycle1.39534335
56MP0006276_abnormal_autonomic_nervous1.39188633
57MP0001984_abnormal_olfaction1.38061336
58MP0004742_abnormal_vestibular_system1.37469335
59MP0005083_abnormal_biliary_tract1.36515585
60MP0001501_abnormal_sleep_pattern1.35854124
61MP0001324_abnormal_eye_pigmentation1.34310171
62MP0004130_abnormal_muscle_cell1.32108124
63MP0002064_seizures1.30832939
64MP0008260_abnormal_autophagy1.29589538
65MP0005646_abnormal_pituitary_gland1.26639685
66MP0003221_abnormal_cardiomyocyte_apopto1.26494251
67MP0002734_abnormal_mechanical_nocicepti1.26379628
68MP0004043_abnormal_pH_regulation1.22451711
69MP0000566_synostosis1.22200994
70MP0000026_abnormal_inner_ear1.21074532
71MP0001963_abnormal_hearing_physiology1.20808001
72MP0001485_abnormal_pinna_reflex1.20773783
73MP0002063_abnormal_learning/memory/cond1.20621415
74MP0005379_endocrine/exocrine_gland_phen1.19463823
75MP0003878_abnormal_ear_physiology1.19120896
76MP0005377_hearing/vestibular/ear_phenot1.19120896
77MP0001440_abnormal_grooming_behavior1.16421885
78MP0002184_abnormal_innervation1.15847821
79MP0002909_abnormal_adrenal_gland1.15627900
80MP0005389_reproductive_system_phenotype1.15167260
81MP0010386_abnormal_urinary_bladder1.13381735
82MP0001919_abnormal_reproductive_system1.12227474
83MP0001502_abnormal_circadian_rhythm1.12142566
84MP0010329_abnormal_lipoprotein_level1.11499394
85MP0002557_abnormal_social/conspecific_i1.10630978
86MP0000631_abnormal_neuroendocrine_gland1.10109139
87MP0005365_abnormal_bile_salt1.09600803
88MP0003698_abnormal_male_reproductive1.09493912
89MP0003283_abnormal_digestive_organ1.09101545
90MP0002752_abnormal_somatic_nervous1.05984391
91MP0002277_abnormal_respiratory_mucosa1.05512973
92MP0005408_hypopigmentation1.04978091
93MP0001905_abnormal_dopamine_level1.04634429
94MP0000778_abnormal_nervous_system1.04021832
95MP0010094_abnormal_chromosome_stability1.03908275
96MP0000371_diluted_coat_color1.02446742
97MP0002938_white_spotting1.00856681
98MP0002075_abnormal_coat/hair_pigmentati0.99559636
99MP0001186_pigmentation_phenotype0.99479774
100MP0002139_abnormal_hepatobiliary_system0.96965513
101MP0002876_abnormal_thyroid_physiology0.95612753
102MP0002160_abnormal_reproductive_system0.92968018
103MP0002138_abnormal_hepatobiliary_system0.91315064
104MP0000383_abnormal_hair_follicle0.91085110
105MP0008995_early_reproductive_senescence0.90628263
106MP0000013_abnormal_adipose_tissue0.90264995
107MP0001929_abnormal_gametogenesis0.89680862
108MP0003879_abnormal_hair_cell0.87265354
109MP0003938_abnormal_ear_development0.86810940
110MP0005332_abnormal_amino_acid0.85140156
111MP0003119_abnormal_digestive_system0.85061260
112MP0005220_abnormal_exocrine_pancreas0.84432290
113MP0005391_vision/eye_phenotype0.84406251
114MP0002751_abnormal_autonomic_nervous0.83927638
115MP0004215_abnormal_myocardial_fiber0.82704554
116MP0002882_abnormal_neuron_morphology0.82423544
117MP0002229_neurodegeneration0.82107532
118MP0003950_abnormal_plasma_membrane0.80458903
119MP0005195_abnormal_posterior_eye0.80387764
120MP0009697_abnormal_copulation0.79617687
121MP0003890_abnormal_embryonic-extraembry0.79507502
122MP0001944_abnormal_pancreas_morphology0.78459651
123MP0001664_abnormal_digestion0.77353210
124MP0002234_abnormal_pharynx_morphology0.76837408
125MP0004885_abnormal_endolymph0.76609429
126MP0000470_abnormal_stomach_morphology0.75741248
127MP0003121_genomic_imprinting0.74868933
128MP0002177_abnormal_outer_ear0.74754880
129MP0001970_abnormal_pain_threshold0.74405354
130MP0003786_premature_aging0.74045635
131MP0004924_abnormal_behavior0.70739058
132MP0005386_behavior/neurological_phenoty0.70739058
133MP0005394_taste/olfaction_phenotype0.69294337
134MP0005499_abnormal_olfactory_system0.69294337
135MP0002210_abnormal_sex_determination0.68652382
136MP0002733_abnormal_thermal_nociception0.68007020
137MP0002009_preneoplasia0.67119567
138MP0003718_maternal_effect0.66086870
139MP0004145_abnormal_muscle_electrophysio0.64314300
140MP0000681_abnormal_thyroid_gland0.63544258

Predicted human phenotypes

RankGene SetZ-score
1Oral leukoplakia (HP:0002745)7.93567266
2Hemiplegia (HP:0002301)5.28745368
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.63386406
4Anomalous pulmonary venous return (HP:0010772)4.54989289
5Dynein arm defect of respiratory motile cilia (HP:0012255)4.38766833
6Absent/shortened dynein arms (HP:0200106)4.38766833
7Congenital stationary night blindness (HP:0007642)4.37367618
8Type II lissencephaly (HP:0007260)4.36527644
9Chromosomal breakage induced by crosslinking agents (HP:0003221)4.23183203
10Cerebellar dysplasia (HP:0007033)4.03124601
11Febrile seizures (HP:0002373)4.02955066
12Abnormality of the pulmonary veins (HP:0011718)4.00774895
13Lipid accumulation in hepatocytes (HP:0006561)3.96054098
14Abnormal ciliary motility (HP:0012262)3.85323219
15Chromsome breakage (HP:0040012)3.82131589
16Abnormal respiratory motile cilium physiology (HP:0012261)3.80383445
17Increased hepatocellular lipid droplets (HP:0006565)3.72094357
18Abnormal respiratory epithelium morphology (HP:0012253)3.67039517
19Abnormal respiratory motile cilium morphology (HP:0005938)3.67039517
20Short femoral neck (HP:0100864)3.62319406
21Abnormality of the pons (HP:0007361)3.61812670
22Aplasia/Hypoplasia of the fovea (HP:0008060)3.60250701
23Hypoplasia of the fovea (HP:0007750)3.60250701
24Abnormality of alanine metabolism (HP:0010916)3.58533561
25Hyperalaninemia (HP:0003348)3.58533561
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.58533561
27Hypoplasia of the pons (HP:0012110)3.52446914
28Amelogenesis imperfecta (HP:0000705)3.51944561
29Focal motor seizures (HP:0011153)3.48580015
30Congenital sensorineural hearing impairment (HP:0008527)3.23340654
31Blue irides (HP:0000635)3.10102452
32Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.07479616
33Pancreatic fibrosis (HP:0100732)3.01902711
34Medial flaring of the eyebrow (HP:0010747)3.00909614
35Abnormality of the fovea (HP:0000493)3.00887772
36Aplasia/Hypoplasia of the macula (HP:0008059)3.00831917
37Leukodystrophy (HP:0002415)2.96161626
38Abnormality of the renal cortex (HP:0011035)2.93378462
39Renal Fanconi syndrome (HP:0001994)2.85650182
40Nephronophthisis (HP:0000090)2.85339392
41Morphological abnormality of the pyramidal tract (HP:0002062)2.85338027
42Decreased central vision (HP:0007663)2.84061406
43Large for gestational age (HP:0001520)2.82558233
44Upper limb muscle weakness (HP:0003484)2.80569222
45Absent rod-and cone-mediated responses on ERG (HP:0007688)2.74711604
46Abnormality of urine glucose concentration (HP:0011016)2.68317057
47Glycosuria (HP:0003076)2.68317057
48Generalized hypopigmentation of hair (HP:0011358)2.67838655
49Aplasia/Hypoplasia affecting the retina (HP:0008061)2.67405321
50Epileptic encephalopathy (HP:0200134)2.65987213
51Calf muscle hypertrophy (HP:0008981)2.64733671
52Rhinitis (HP:0012384)2.64263901
53Attenuation of retinal blood vessels (HP:0007843)2.62764249
54True hermaphroditism (HP:0010459)2.62547624
55Oligodontia (HP:0000677)2.60022034
56Mitochondrial inheritance (HP:0001427)2.59991082
57White forelock (HP:0002211)2.55233056
58Tubulointerstitial nephritis (HP:0001970)2.54601423
59Abnormal rod and cone electroretinograms (HP:0008323)2.53875748
60Stomach cancer (HP:0012126)2.53188268
61CNS hypomyelination (HP:0003429)2.52339419
62Excessive salivation (HP:0003781)2.51605304
63Patchy hypopigmentation of hair (HP:0011365)2.51232955
64Duplicated collecting system (HP:0000081)2.50938563
65Pancreatic cysts (HP:0001737)2.50645312
66Renal cortical cysts (HP:0000803)2.50512559
67Gait imbalance (HP:0002141)2.49050650
68Congenital primary aphakia (HP:0007707)2.48910837
69Upper motor neuron abnormality (HP:0002127)2.46714016
70Protruding tongue (HP:0010808)2.46343668
71Abnormality of midbrain morphology (HP:0002418)2.46223467
72Molar tooth sign on MRI (HP:0002419)2.46223467
73Abnormality of the renal collecting system (HP:0004742)2.45472045
74Rough bone trabeculation (HP:0100670)2.44742690
75Abnormality of the renal medulla (HP:0100957)2.44186027
76Hyperglycinemia (HP:0002154)2.43690533
77Aplasia/hypoplasia of the femur (HP:0005613)2.43437963
78Premature graying of hair (HP:0002216)2.42646659
79Lissencephaly (HP:0001339)2.40126939
80Nephrogenic diabetes insipidus (HP:0009806)2.38083236
81Severe muscular hypotonia (HP:0006829)2.37479829
82Increased CSF lactate (HP:0002490)2.37189815
83Vertebral fusion (HP:0002948)2.36823861
84Prostate neoplasm (HP:0100787)2.35170364
85Tubular atrophy (HP:0000092)2.34709777
86Abnormality of the preputium (HP:0100587)2.33013462
87Exertional dyspnea (HP:0002875)2.32351323
88Postaxial foot polydactyly (HP:0001830)2.28086586
89Increased intramyocellular lipid droplets (HP:0012240)2.28024231
90Microvesicular hepatic steatosis (HP:0001414)2.27452437
91Abnormality of DNA repair (HP:0003254)2.27142452
92Hypothermia (HP:0002045)2.26531513
93Pachygyria (HP:0001302)2.26034848
94Bony spicule pigmentary retinopathy (HP:0007737)2.25978609
95Muscle hypertrophy of the lower extremities (HP:0008968)2.25119673
96Abnormality of the intervertebral disk (HP:0005108)2.24413552
97Hemivertebrae (HP:0002937)2.23530160
98Aplasia/Hypoplasia of the uvula (HP:0010293)2.21097441
99Hepatic necrosis (HP:0002605)2.19522042
100Cystic liver disease (HP:0006706)2.19200259
101Ocular albinism (HP:0001107)2.19050074
102Fair hair (HP:0002286)2.18221797
103Septo-optic dysplasia (HP:0100842)2.18159377
104Meningocele (HP:0002435)2.17103111
105Hypogonadotrophic hypogonadism (HP:0000044)2.15124484
106Iris hypopigmentation (HP:0007730)2.13173625
107Increased muscle lipid content (HP:0009058)2.12387844
108Generalized hypopigmentation (HP:0007513)2.12097071
109Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.11736806
110Abolished electroretinogram (ERG) (HP:0000550)2.09936067
111Hepatocellular necrosis (HP:0001404)2.09160627
112Inability to walk (HP:0002540)2.09052990
113Median cleft lip (HP:0000161)2.09021746
114Meckel diverticulum (HP:0002245)2.05080743
115Optic nerve hypoplasia (HP:0000609)2.03873919
116Hyperphosphaturia (HP:0003109)1.99962118
117Aplasia/Hypoplasia of the tibia (HP:0005772)1.99459001
118Severe visual impairment (HP:0001141)1.99352295
119Astigmatism (HP:0000483)1.99014681
120Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97969069
121Abnormality of the ileum (HP:0001549)1.97682636
122Aganglionic megacolon (HP:0002251)1.95946075
123Abnormality of chromosome stability (HP:0003220)1.95046664
124Poor coordination (HP:0002370)1.94892970
125Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.93996726
126Hyperventilation (HP:0002883)1.93644316
127Genital tract atresia (HP:0001827)1.92872838
128Nephroblastoma (Wilms tumor) (HP:0002667)1.92397728
129Abnormality of serum amino acid levels (HP:0003112)1.92259766
130Pendular nystagmus (HP:0012043)1.92252383
131Congenital hepatic fibrosis (HP:0002612)1.92230604
132Short tibia (HP:0005736)1.92222461
133Myelomeningocele (HP:0002475)1.92060276
134Broad-based gait (HP:0002136)1.90569222
135Chorioretinal coloboma (HP:0000567)1.90375708
136Abnormal trabecular bone morphology (HP:0100671)1.90262039
137Atonic seizures (HP:0010819)1.89927497
138Chronic hepatic failure (HP:0100626)1.89753318
139Clubbing of toes (HP:0100760)1.88179052
140Preaxial hand polydactyly (HP:0001177)1.87993050
141Male pseudohermaphroditism (HP:0000037)1.87459784
142Chorioretinal atrophy (HP:0000533)1.86158150
143Atelectasis (HP:0100750)1.86112452
144Polydipsia (HP:0001959)1.85692800
145Abnormal drinking behavior (HP:0030082)1.85692800
146Gaze-evoked nystagmus (HP:0000640)1.85058874
147Postural tremor (HP:0002174)1.84600654
148Abnormal hair whorl (HP:0010721)1.83458473
149Vaginal atresia (HP:0000148)1.82039566
150Aplasia/Hypoplasia of the lens (HP:0008063)1.80481269
151Increased serum lactate (HP:0002151)1.80353876
152Absent speech (HP:0001344)1.80008625
153Increased corneal curvature (HP:0100692)1.78842634
154Keratoconus (HP:0000563)1.78842634
155Overlapping toe (HP:0001845)1.78502504
156Photophobia (HP:0000613)1.76536867
157Abnormality of macular pigmentation (HP:0008002)1.75880803
158Embryonal renal neoplasm (HP:0011794)1.74837032
159Progressive inability to walk (HP:0002505)1.74543434
160Abnormality of the carotid arteries (HP:0005344)1.74321748
161Submucous cleft hard palate (HP:0000176)1.73976998
162Progressive cerebellar ataxia (HP:0002073)1.73930567
163Abnormality of the odontoid process (HP:0003310)1.73268193
164Delayed gross motor development (HP:0002194)1.71871463
165Abnormality of renal resorption (HP:0011038)1.71668599
166Aplasia/hypoplasia of the uterus (HP:0008684)1.71650369
167Esotropia (HP:0000565)1.71252593
168Frequent falls (HP:0002359)1.71203604
169Abnormality of glycine metabolism (HP:0010895)1.70819422
170Abnormality of serine family amino acid metabolism (HP:0010894)1.70819422
171Hyperglycinuria (HP:0003108)1.70250572
172Sensory axonal neuropathy (HP:0003390)1.69063708
173Concave nail (HP:0001598)1.68773485
174Facial cleft (HP:0002006)1.68267349
175Dyschromatopsia (HP:0007641)1.68221499
176Drooling (HP:0002307)1.67923087

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.07891260
2CASK3.98541053
3STK163.77231394
4FRK3.15579979
5MAP2K43.00895075
6GRK12.68518212
7NTRK32.66331237
8MKNK22.39342068
9MST1R2.19752122
10MAP2K72.01597889
11EIF2AK22.00812441
12SRPK11.99796155
13TXK1.98384608
14AKT31.92859216
15PNCK1.79781105
16ZAK1.76000311
17EPHA41.75197335
18YES11.68534728
19MUSK1.67268096
20BMPR21.64929414
21BRD41.64536293
22RIPK41.58631910
23CDK31.58165329
24MKNK11.58004769
25PRPF4B1.54903237
26MAP4K21.49844158
27MAPKAPK31.47098638
28NEK61.38626046
29INSRR1.38620863
30FER1.26858467
31PLK21.25638847
32ACVR1B1.22324554
33PLK41.22262720
34BRSK21.18927151
35MAPK131.18666284
36TNK21.18499095
37WNK41.18359419
38PINK11.17540756
39ADRBK21.15901134
40MAP3K41.13949434
41BLK1.13382921
42NUAK11.12796014
43GRK71.12265191
44TLK11.10967718
45MAPK151.09702432
46MAP3K131.09408504
47MARK11.06141439
48SGK21.02356945
49IRAK11.00341296
50IRAK41.00086202
51VRK10.98206152
52MAP3K140.97641340
53WEE10.97515976
54NME10.94805022
55BMPR1B0.93224833
56PRKCE0.86324764
57SIK20.86139888
58IRAK20.83926633
59CAMK2B0.83890813
60TSSK60.83048588
61TEC0.81821778
62EPHA30.78910051
63OXSR10.78188507
64DYRK1A0.74875273
65WNK30.74320606
66EEF2K0.74045885
67DAPK20.73474528
68RET0.73216301
69CLK10.72830611
70MARK30.70914726
71FES0.70545355
72CAMK2A0.69645293
73PIK3CG0.69448418
74SGK2230.68352108
75SGK4940.68352108
76CCNB10.66405899
77NLK0.64616435
78PRKCG0.64327495
79STK390.63939511
80SGK10.63559248
81PLK30.63325490
82ADRBK10.61670224
83CSNK1G10.61655612
84MAP3K120.60764628
85IRAK30.59895117
86DAPK30.58749102
87CSNK1G20.56568163
88IKBKE0.55723149
89NTRK20.55645503
90RPS6KA50.55181410
91DYRK20.54630218
92CSNK1A1L0.54576638
93PKN10.54378979
94CAMKK20.54338363
95BRAF0.53990876
96CHEK20.53944547
97CSNK1G30.53538674
98CAMK2D0.50652189
99PRKAA10.50399446
100PTK2B0.50210384
101PAK30.49056239
102PIM10.48479127
103LYN0.47110987
104PRKCQ0.45258122
105FGR0.44143092
106AURKA0.43871643
107CAMK10.41169079
108PRKG10.40758243
109ERBB30.39732180
110MST40.38912539
111PBK0.38847748
112TRPM70.38785949
113CDK190.38183529
114MAP3K60.37436432
115PRKCI0.37087033
116ATR0.35172151
117STK110.35031302
118PRKACA0.34831064
119PLK10.34674756
120MAPKAPK50.34615317
121SIK30.34112113
122PRKCZ0.33954058
123MAP2K60.33732449
124TAOK30.33571833
125ATM0.31731970
126LCK0.31362751
127EIF2AK30.31131623
128ILK0.31037022
129CDK80.31024678
130STK40.30595512
131PRKAA20.30203431
132CSNK1A10.29877095
133MAP2K10.28831058
134TGFBR10.28773400
135SYK0.28736367
136BCR0.28494040
137MAPK100.28167858
138BCKDK0.27300361
139MAPK110.26507009
140NEK20.24442354
141CDC70.22881571
142BRSK10.22238309
143CAMKK10.22216463
144PRKCA0.21211907
145CDK90.20914604
146TRIM280.20621003
147RPS6KB20.20570726
148PHKG10.17783554
149PHKG20.17783554
150PAK60.17768472
151PRKCH0.17356502
152CAMK40.14882980

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.86650050
2Phototransduction_Homo sapiens_hsa047443.73425718
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.40472179
4Selenocompound metabolism_Homo sapiens_hsa004503.26516260
5Butanoate metabolism_Homo sapiens_hsa006502.66818017
6Fanconi anemia pathway_Homo sapiens_hsa034602.62134889
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34764137
8Tryptophan metabolism_Homo sapiens_hsa003802.22841130
9Taste transduction_Homo sapiens_hsa047422.15809346
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.14211985
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.13852387
12Morphine addiction_Homo sapiens_hsa050322.02541136
13Homologous recombination_Homo sapiens_hsa034402.00225388
14Nitrogen metabolism_Homo sapiens_hsa009101.99167416
15Glutamatergic synapse_Homo sapiens_hsa047241.82077712
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81749173
17Serotonergic synapse_Homo sapiens_hsa047261.79764368
18Non-homologous end-joining_Homo sapiens_hsa034501.72611302
19Sulfur metabolism_Homo sapiens_hsa009201.59753536
20Circadian entrainment_Homo sapiens_hsa047131.58755610
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.58660394
22Parkinsons disease_Homo sapiens_hsa050121.56975103
23Basal transcription factors_Homo sapiens_hsa030221.56704128
24RNA polymerase_Homo sapiens_hsa030201.53543682
25GABAergic synapse_Homo sapiens_hsa047271.51169923
26Sphingolipid metabolism_Homo sapiens_hsa006001.43052475
27Amphetamine addiction_Homo sapiens_hsa050311.40393055
28Caffeine metabolism_Homo sapiens_hsa002321.37736846
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36364029
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27088999
31Calcium signaling pathway_Homo sapiens_hsa040201.25245735
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23234797
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20881912
34Histidine metabolism_Homo sapiens_hsa003401.18511261
35Ether lipid metabolism_Homo sapiens_hsa005651.18041309
36Primary immunodeficiency_Homo sapiens_hsa053401.16055462
37Chemical carcinogenesis_Homo sapiens_hsa052041.14952393
38Purine metabolism_Homo sapiens_hsa002301.14365761
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12273339
40Olfactory transduction_Homo sapiens_hsa047401.11753533
41Autoimmune thyroid disease_Homo sapiens_hsa053201.10799768
42Sulfur relay system_Homo sapiens_hsa041221.10088895
43Collecting duct acid secretion_Homo sapiens_hsa049661.10044825
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09978575
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08851500
46Peroxisome_Homo sapiens_hsa041461.08770598
47Regulation of autophagy_Homo sapiens_hsa041401.08474787
48Circadian rhythm_Homo sapiens_hsa047101.08150140
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06921598
50Dopaminergic synapse_Homo sapiens_hsa047281.05529001
51Salivary secretion_Homo sapiens_hsa049701.05405327
52Long-term depression_Homo sapiens_hsa047301.02207732
53Nucleotide excision repair_Homo sapiens_hsa034201.02161738
54Glycerolipid metabolism_Homo sapiens_hsa005611.01911951
55Synaptic vesicle cycle_Homo sapiens_hsa047211.01074882
56Insulin secretion_Homo sapiens_hsa049111.00736631
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99665279
58Glutathione metabolism_Homo sapiens_hsa004800.99546202
59Alzheimers disease_Homo sapiens_hsa050100.99333106
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97110098
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95987207
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95977804
63Long-term potentiation_Homo sapiens_hsa047200.95946346
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.94138149
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90353056
66Cocaine addiction_Homo sapiens_hsa050300.89232049
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88902406
68RNA degradation_Homo sapiens_hsa030180.88335175
69Cardiac muscle contraction_Homo sapiens_hsa042600.87726156
70ABC transporters_Homo sapiens_hsa020100.87245348
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85543023
72Protein export_Homo sapiens_hsa030600.84506070
73beta-Alanine metabolism_Homo sapiens_hsa004100.84104372
74Linoleic acid metabolism_Homo sapiens_hsa005910.83111231
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82842822
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82805449
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82312487
78Graft-versus-host disease_Homo sapiens_hsa053320.81351381
79Hematopoietic cell lineage_Homo sapiens_hsa046400.81038819
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.80994315
81cAMP signaling pathway_Homo sapiens_hsa040240.80433752
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80082218
83Pyrimidine metabolism_Homo sapiens_hsa002400.79655734
84Alcoholism_Homo sapiens_hsa050340.79580834
85Cholinergic synapse_Homo sapiens_hsa047250.79478877
86Inositol phosphate metabolism_Homo sapiens_hsa005620.79028963
87Mismatch repair_Homo sapiens_hsa034300.76360103
88Vitamin B6 metabolism_Homo sapiens_hsa007500.76056171
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.76025784
90Thyroid hormone synthesis_Homo sapiens_hsa049180.74049300
91Renin secretion_Homo sapiens_hsa049240.73869221
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.73603582
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.72001936
94Arachidonic acid metabolism_Homo sapiens_hsa005900.71776561
95Rheumatoid arthritis_Homo sapiens_hsa053230.70783865
96Systemic lupus erythematosus_Homo sapiens_hsa053220.69488557
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67665310
98Arginine and proline metabolism_Homo sapiens_hsa003300.66083005
99Steroid biosynthesis_Homo sapiens_hsa001000.65015618
100Axon guidance_Homo sapiens_hsa043600.64863387
101Oxytocin signaling pathway_Homo sapiens_hsa049210.64126588
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61414892
103Fat digestion and absorption_Homo sapiens_hsa049750.61104261
104mRNA surveillance pathway_Homo sapiens_hsa030150.61080982
105One carbon pool by folate_Homo sapiens_hsa006700.61070116
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60924556
107Allograft rejection_Homo sapiens_hsa053300.60918029
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60424861
109Measles_Homo sapiens_hsa051620.60259482
110Asthma_Homo sapiens_hsa053100.58830707
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57975399
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57564046
113Propanoate metabolism_Homo sapiens_hsa006400.57066215
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.56934348
115Retinol metabolism_Homo sapiens_hsa008300.56603748
116T cell receptor signaling pathway_Homo sapiens_hsa046600.55904376
117Metabolic pathways_Homo sapiens_hsa011000.55523504
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54976280
119Spliceosome_Homo sapiens_hsa030400.54391412
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54297886
121Melanogenesis_Homo sapiens_hsa049160.51597226
122Huntingtons disease_Homo sapiens_hsa050160.51351751
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50393905
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49993662
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.49410479
126Hedgehog signaling pathway_Homo sapiens_hsa043400.49214582
127Base excision repair_Homo sapiens_hsa034100.47847252
128Mineral absorption_Homo sapiens_hsa049780.47830908
129Choline metabolism in cancer_Homo sapiens_hsa052310.47433082
130Type II diabetes mellitus_Homo sapiens_hsa049300.47206325
131Oxidative phosphorylation_Homo sapiens_hsa001900.46807092
132Ras signaling pathway_Homo sapiens_hsa040140.46376968
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45962796
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44516957
135Wnt signaling pathway_Homo sapiens_hsa043100.44270005
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44213198
137Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43633425
138Gastric acid secretion_Homo sapiens_hsa049710.43601795
139Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43034420
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42678434
141Pancreatic secretion_Homo sapiens_hsa049720.41682272
142Vitamin digestion and absorption_Homo sapiens_hsa049770.41559620
143Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41500229
144Bile secretion_Homo sapiens_hsa049760.41340346
145MAPK signaling pathway_Homo sapiens_hsa040100.41188914
146Ovarian steroidogenesis_Homo sapiens_hsa049130.40814167
147ErbB signaling pathway_Homo sapiens_hsa040120.40800644
148Tyrosine metabolism_Homo sapiens_hsa003500.39011995
149Fatty acid degradation_Homo sapiens_hsa000710.35069387

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »