WDR33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is highly expressed in testis and the protein is localized to the nucleus. This gene may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.92143605
2nuclear pore organization (GO:0006999)4.82140565
3protein localization to kinetochore (GO:0034501)4.32755036
4histone H3-K36 demethylation (GO:0070544)4.28733321
5negative regulation of DNA repair (GO:0045738)4.16912348
6sister chromatid cohesion (GO:0007062)4.02469613
7DNA unwinding involved in DNA replication (GO:0006268)4.01430474
8mitotic metaphase plate congression (GO:0007080)4.01017459
9mitotic nuclear envelope disassembly (GO:0007077)3.95615802
10kinetochore organization (GO:0051383)3.89461183
11pore complex assembly (GO:0046931)3.85839958
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.84634100
13protein localization to chromosome, centromeric region (GO:0071459)3.75709871
14mitotic sister chromatid segregation (GO:0000070)3.70824755
15nuclear envelope disassembly (GO:0051081)3.67576785
16membrane disassembly (GO:0030397)3.67576785
17regulation of sister chromatid cohesion (GO:0007063)3.66918645
18metaphase plate congression (GO:0051310)3.65999043
19positive regulation of cell cycle checkpoint (GO:1901978)3.64991912
20DNA replication initiation (GO:0006270)3.61111439
21mitotic chromosome condensation (GO:0007076)3.55573504
22DNA replication-dependent nucleosome organization (GO:0034723)3.55416333
23DNA replication-dependent nucleosome assembly (GO:0006335)3.55416333
24sister chromatid segregation (GO:0000819)3.55076432
25DNA synthesis involved in DNA repair (GO:0000731)3.53646488
26positive regulation of chromosome segregation (GO:0051984)3.51986878
27attachment of spindle microtubules to kinetochore (GO:0008608)3.51755966
28regulation of NFAT protein import into nucleus (GO:0051532)3.50850214
29IMP biosynthetic process (GO:0006188)3.50602381
30DNA strand elongation involved in DNA replication (GO:0006271)3.50377290
31regulation of nucleobase-containing compound transport (GO:0032239)3.45812236
32histone lysine demethylation (GO:0070076)3.45074052
33meiotic chromosome segregation (GO:0045132)3.44618800
34regulation of histone H3-K9 methylation (GO:0051570)3.44258402
35non-recombinational repair (GO:0000726)3.44029397
36double-strand break repair via nonhomologous end joining (GO:0006303)3.44029397
37mitotic sister chromatid cohesion (GO:0007064)3.42120849
38pre-miRNA processing (GO:0031054)3.41434252
39histone H3-K9 demethylation (GO:0033169)3.40687730
40kinetochore assembly (GO:0051382)3.40458036
41chromatin remodeling at centromere (GO:0031055)3.40404127
42spliceosomal tri-snRNP complex assembly (GO:0000244)3.39711593
43negative regulation of histone methylation (GO:0031061)3.39581407
44CENP-A containing nucleosome assembly (GO:0034080)3.34892817
45regulation of DNA damage checkpoint (GO:2000001)3.34771134
46regulation of gene silencing by RNA (GO:0060966)3.34286118
47regulation of posttranscriptional gene silencing (GO:0060147)3.34286118
48regulation of gene silencing by miRNA (GO:0060964)3.34286118
49folic acid-containing compound biosynthetic process (GO:0009396)3.34050146
50DNA strand elongation (GO:0022616)3.33424485
51DNA replication-independent nucleosome assembly (GO:0006336)3.33139268
52DNA replication-independent nucleosome organization (GO:0034724)3.33139268
53nucleobase biosynthetic process (GO:0046112)3.32224197
54DNA duplex unwinding (GO:0032508)3.29643928
55establishment of chromosome localization (GO:0051303)3.29256540
56DNA replication checkpoint (GO:0000076)3.29042695
57embryonic process involved in female pregnancy (GO:0060136)3.28636609
58DNA geometric change (GO:0032392)3.28518272
59dosage compensation (GO:0007549)3.24215302
60regulation of spindle organization (GO:0090224)3.24077824
61DNA topological change (GO:0006265)3.21320515
62regulation of chromosome segregation (GO:0051983)3.20896636
63histone demethylation (GO:0016577)3.20148621
64spindle checkpoint (GO:0031577)3.20111633
65regulation of RNA export from nucleus (GO:0046831)3.18844231
66telomere maintenance via semi-conservative replication (GO:0032201)3.16610778
67somatic hypermutation of immunoglobulin genes (GO:0016446)3.16039590
68somatic diversification of immune receptors via somatic mutation (GO:0002566)3.16039590
69protein localization to chromosome (GO:0034502)3.15617881
70histone H4-K16 acetylation (GO:0043984)3.15581095
71spindle assembly checkpoint (GO:0071173)3.14868743
72negative regulation of chromosome segregation (GO:0051985)3.14775883
73positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.13385693
74positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.13385693
75positive regulation of mitotic sister chromatid separation (GO:1901970)3.13385693
76negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.11544916
77negative regulation of sister chromatid segregation (GO:0033046)3.11544916
78negative regulation of mitotic sister chromatid separation (GO:2000816)3.11544916
79negative regulation of mitotic sister chromatid segregation (GO:0033048)3.11544916
80mitotic spindle assembly checkpoint (GO:0007094)3.11240706
81histone exchange (GO:0043486)3.09998883
82mitotic spindle checkpoint (GO:0071174)3.07868472
83regulation of mitotic metaphase/anaphase transition (GO:0030071)3.06988172
84ATP-dependent chromatin remodeling (GO:0043044)3.06932106
85mitotic recombination (GO:0006312)3.05114286
86histone H2A acetylation (GO:0043968)3.04869575
87negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.04722672
88telomere maintenance via recombination (GO:0000722)3.04158844
89regulation of centriole replication (GO:0046599)3.03263911
90establishment of integrated proviral latency (GO:0075713)3.02022525
91regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.01820001
92mRNA export from nucleus (GO:0006406)3.01559155
93mismatch repair (GO:0006298)3.00480996
94cytoplasmic mRNA processing body assembly (GO:0033962)2.99684248
95regulation of sister chromatid segregation (GO:0033045)2.99393194
96regulation of mitotic sister chromatid separation (GO:0010965)2.99393194
97regulation of mitotic sister chromatid segregation (GO:0033047)2.99393194
98regulation of chromatin silencing (GO:0031935)2.97934980
99chromatin assembly or disassembly (GO:0006333)2.97355245
100negative regulation of RNA splicing (GO:0033119)2.95738613
101inner cell mass cell proliferation (GO:0001833)2.95185885
102V(D)J recombination (GO:0033151)2.95021624
103formation of translation preinitiation complex (GO:0001731)2.94932731
104chromosome segregation (GO:0007059)2.94406513
105maturation of 5.8S rRNA (GO:0000460)2.93600958
106regulation of helicase activity (GO:0051095)2.92319448
107regulation of DNA endoreduplication (GO:0032875)2.92182242
108peptidyl-lysine dimethylation (GO:0018027)2.92028569
109mRNA stabilization (GO:0048255)2.91297636
110RNA stabilization (GO:0043489)2.91297636
111monoubiquitinated protein deubiquitination (GO:0035520)2.91281954
112purine nucleobase biosynthetic process (GO:0009113)2.91031251
113RNA export from nucleus (GO:0006405)2.90460701
114protein K6-linked ubiquitination (GO:0085020)2.90028093
115DNA conformation change (GO:0071103)2.88116694
116negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.88103016
117telomere maintenance via telomere lengthening (GO:0010833)2.87577284
118regulation of telomere maintenance via telomerase (GO:0032210)2.86726593
119negative regulation of mRNA metabolic process (GO:1903312)2.86724238
120protein export from nucleus (GO:0006611)2.86539162
121nucleic acid transport (GO:0050657)2.86327147
122RNA transport (GO:0050658)2.86327147
123establishment of RNA localization (GO:0051236)2.86327147
124negative regulation of mRNA processing (GO:0050686)2.85748283
125RNA splicing, via transesterification reactions (GO:0000375)2.85641850
126histone H2A monoubiquitination (GO:0035518)2.85469929
127IMP metabolic process (GO:0046040)2.84987595
128regulation of centrosome duplication (GO:0010824)2.84042120
129mRNA transport (GO:0051028)2.83925487
130mRNA splicing, via spliceosome (GO:0000398)2.83804485
131RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.83804485
132regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.83674531
133regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.83598172
134glucocorticoid receptor signaling pathway (GO:0042921)2.83260452
135nucleotide-excision repair, DNA gap filling (GO:0006297)2.82739519
136intra-S DNA damage checkpoint (GO:0031573)2.80807110
137nucleus organization (GO:0006997)2.80625950
138maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80387086
139nuclear envelope organization (GO:0006998)2.80009936
140ribosome assembly (GO:0042255)2.79404258
141protein demethylation (GO:0006482)2.79157123
142protein dealkylation (GO:0008214)2.79157123
143nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.76412680

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.59520717
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.91516493
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.08632401
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.60744453
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.45538666
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.79241873
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.74562300
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.72289271
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68459992
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.64976988
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54007505
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.50492380
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.47946738
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.40329840
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.39157271
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28680864
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26620975
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.21505652
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21035763
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.20281396
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19404173
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19199840
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17259133
24GABP_17652178_ChIP-ChIP_JURKAT_Human2.17214144
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.14650708
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.14458588
27ETS1_20019798_ChIP-Seq_JURKAT_Human2.12259090
28XRN2_22483619_ChIP-Seq_HELA_Human2.07124182
29AR_21909140_ChIP-Seq_LNCAP_Human2.06337259
30* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.05004254
31* VDR_23849224_ChIP-Seq_CD4+_Human2.01225457
32SALL1_21062744_ChIP-ChIP_HESCs_Human2.00806551
33MYC_22102868_ChIP-Seq_BL_Human2.00527181
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.93397298
35FOXP3_21729870_ChIP-Seq_TREG_Human1.90557542
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89022844
37CIITA_25753668_ChIP-Seq_RAJI_Human1.85819572
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.85365617
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78917930
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76820100
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71757531
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66693851
43KDM5A_27292631_Chip-Seq_BREAST_Human1.62390638
44* ELK1_19687146_ChIP-ChIP_HELA_Human1.60603205
45GABP_19822575_ChIP-Seq_HepG2_Human1.58921752
46DCP1A_22483619_ChIP-Seq_HELA_Human1.56354119
47TTF2_22483619_ChIP-Seq_HELA_Human1.56119973
48* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55382503
49* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55315219
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55170346
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55101855
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52550012
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50020591
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.48856607
55SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.47833776
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47824924
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44829733
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42881973
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41021493
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37648004
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37366169
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36369394
63DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32520924
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29172033
65* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27190912
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25563379
67FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.22385612
68CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21222549
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.21071718
70NANOG_21062744_ChIP-ChIP_HESCs_Human1.18809141
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17494889
72FUS_26573619_Chip-Seq_HEK293_Human1.16163690
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13909973
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13761414
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11743802
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09281218
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08841720
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08744077
79FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06913530
80GATA1_22025678_ChIP-Seq_K562_Human1.04488365
81TFEB_21752829_ChIP-Seq_HELA_Human1.04156279
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03434842
83TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03095021
84* SRF_21415370_ChIP-Seq_HL-1_Mouse1.02452523
85E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02074871
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99659055
87MYC_18940864_ChIP-ChIP_HL60_Human0.95240358
88DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95166776
89CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95117657
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94368122
91NOTCH1_21737748_ChIP-Seq_TLL_Human0.93037331
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92951113
93KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92610289
94* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92534593
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92517447
96FLI1_27457419_Chip-Seq_LIVER_Mouse0.92226136
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89629059
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89407484
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88584365
100FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85658688
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84653034
102SOX17_20123909_ChIP-Seq_XEN_Mouse0.84370074
103SOX2_16153702_ChIP-ChIP_HESCs_Human0.84333903
104EWS_26573619_Chip-Seq_HEK293_Human0.84054406
105KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.82925708
106KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82925708
107KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.82925708
108VDR_21846776_ChIP-Seq_THP-1_Human0.81872804
109IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.81717928
110TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80706683
111STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.80386965
112PKCTHETA_26484144_Chip-Seq_BREAST_Human0.79857229
113STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77988555
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77139737
115MYB_26560356_Chip-Seq_TH1_Human0.76961700
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.75911771
117NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.75743966
118HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.72745523
119MYB_26560356_Chip-Seq_TH2_Human0.72319519
120CHD1_26751641_Chip-Seq_LNCaP_Human0.71526843

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.30247772
2MP0003693_abnormal_embryo_hatching4.17279624
3MP0003111_abnormal_nucleus_morphology3.93417443
4MP0008057_abnormal_DNA_replication3.68990421
5MP0003077_abnormal_cell_cycle3.60287269
6MP0004957_abnormal_blastocyst_morpholog3.57069496
7MP0008877_abnormal_DNA_methylation3.48544848
8MP0008058_abnormal_DNA_repair3.14122376
9MP0008007_abnormal_cellular_replicative3.07076239
10MP0002009_preneoplasia2.87687604
11MP0003123_paternal_imprinting2.66234809
12MP0001730_embryonic_growth_arrest2.33081562
13MP0003121_genomic_imprinting2.31231225
14MP0002396_abnormal_hematopoietic_system2.31198211
15MP0008932_abnormal_embryonic_tissue2.25713408
16MP0000350_abnormal_cell_proliferation2.18679745
17MP0010234_abnormal_vibrissa_follicle2.13753105
18MP0010352_gastrointestinal_tract_polyps2.04922104
19MP0003786_premature_aging1.94494463
20MP0003787_abnormal_imprinting1.89625253
21MP0010307_abnormal_tumor_latency1.88335859
22MP0001672_abnormal_embryogenesis/_devel1.87053682
23MP0005380_embryogenesis_phenotype1.87053682
24MP0003763_abnormal_thymus_physiology1.86670656
25MP0005409_darkened_coat_color1.82646212
26MP0003221_abnormal_cardiomyocyte_apopto1.74914778
27MP0001697_abnormal_embryo_size1.73618193
28MP0003984_embryonic_growth_retardation1.69195096
29MP0002085_abnormal_embryonic_tissue1.67029005
30MP0002084_abnormal_developmental_patter1.66556929
31MP0002088_abnormal_embryonic_growth/wei1.65489336
32MP0004185_abnormal_adipocyte_glucose1.63971056
33MP0005076_abnormal_cell_differentiation1.61871100
34MP0004197_abnormal_fetal_growth/weight/1.61111478
35MP0003890_abnormal_embryonic-extraembry1.57425405
36MP0006292_abnormal_olfactory_placode1.55318805
37MP0002653_abnormal_ependyma_morphology1.53122417
38MP0002080_prenatal_lethality1.49106052
39MP0002210_abnormal_sex_determination1.49059309
40MP0002086_abnormal_extraembryonic_tissu1.43569340
41MP0010030_abnormal_orbit_morphology1.41590547
42MP0000313_abnormal_cell_death1.36337978
43MP0000703_abnormal_thymus_morphology1.36295013
44MP0003119_abnormal_digestive_system1.32187587
45MP0001929_abnormal_gametogenesis1.31484956
46MP0004808_abnormal_hematopoietic_stem1.31011291
47MP0000490_abnormal_crypts_of1.30185200
48MP0001145_abnormal_male_reproductive1.25635813
49MP0008995_early_reproductive_senescence1.25545936
50MP0002166_altered_tumor_susceptibility1.25062579
51MP0002697_abnormal_eye_size1.23986121
52MP0001293_anophthalmia1.20552170
53MP0003941_abnormal_skin_development1.18973385
54MP0002019_abnormal_tumor_incidence1.18103617
55MP0000653_abnormal_sex_gland1.17419945
56MP0002398_abnormal_bone_marrow1.11254565
57MP0003937_abnormal_limbs/digits/tail_de1.08402918
58MP0000537_abnormal_urethra_morphology1.08078798
59MP0009672_abnormal_birth_weight1.04306503
60MP0009333_abnormal_splenocyte_physiolog1.04140379
61MP0002796_impaired_skin_barrier1.00790590
62MP0000462_abnormal_digestive_system1.00365500
63MP0003567_abnormal_fetal_cardiomyocyte0.99793054
64MP0001119_abnormal_female_reproductive0.97379592
65MP0009703_decreased_birth_body0.96654141
66MP0000569_abnormal_digit_pigmentation0.95420014
67MP0000516_abnormal_urinary_system0.94402843
68MP0005367_renal/urinary_system_phenotyp0.94402843
69MP0002132_abnormal_respiratory_system0.94234809
70MP0003718_maternal_effect0.93472712
71MP0002089_abnormal_postnatal_growth/wei0.93016716
72MP0003315_abnormal_perineum_morphology0.92900784
73MP0010678_abnormal_skin_adnexa0.92415963
74MP0009053_abnormal_anal_canal0.92255794
75MP0005310_abnormal_salivary_gland0.91841735
76MP0005666_abnormal_adipose_tissue0.91002831
77MP0002722_abnormal_immune_system0.90870044
78MP0002092_abnormal_eye_morphology0.89444461
79MP0008789_abnormal_olfactory_epithelium0.89320176
80MP0000428_abnormal_craniofacial_morphol0.88258155
81MP0002111_abnormal_tail_morphology0.85944638
82MP0003698_abnormal_male_reproductive0.84763497
83MP0000678_abnormal_parathyroid_gland0.83623533
84MP0000689_abnormal_spleen_morphology0.83274080
85MP0001286_abnormal_eye_development0.82607199
86MP0001661_extended_life_span0.81966680
87MP0003283_abnormal_digestive_organ0.81637040
88MP0001188_hyperpigmentation0.79740829
89MP0002006_tumorigenesis0.78136429
90MP0006035_abnormal_mitochondrial_morpho0.75514041
91MP0000432_abnormal_head_morphology0.74260831
92MP0000598_abnormal_liver_morphology0.74059937
93MP0005220_abnormal_exocrine_pancreas0.73592188
94MP0002938_white_spotting0.73581135
95MP0003453_abnormal_keratinocyte_physiol0.73389918
96MP0005389_reproductive_system_phenotype0.72995605
97MP0002877_abnormal_melanocyte_morpholog0.72889395
98MP0005671_abnormal_response_to0.72741140
99MP0003115_abnormal_respiratory_system0.72424193
100MP0002429_abnormal_blood_cell0.72084440
101MP0003935_abnormal_craniofacial_develop0.71978252
102MP0001915_intracranial_hemorrhage0.71381083
103MP0003861_abnormal_nervous_system0.71067871
104MP0002925_abnormal_cardiovascular_devel0.70481933
105MP0001873_stomach_inflammation0.70396255
106MP0000358_abnormal_cell_content/0.70240085
107MP0003943_abnormal_hepatobiliary_system0.69666500
108MP0008260_abnormal_autophagy0.69478095
109MP0002932_abnormal_joint_morphology0.68551460
110MP0005384_cellular_phenotype0.68294695
111MP0001849_ear_inflammation0.68023425
112MP0000716_abnormal_immune_system0.67910001
113MP0002160_abnormal_reproductive_system0.67868079
114MP0005187_abnormal_penis_morphology0.67716219
115MP0005621_abnormal_cell_physiology0.67433455
116MP0004264_abnormal_extraembryonic_tissu0.66774317
117MP0002114_abnormal_axial_skeleton0.66604017
118MP0000015_abnormal_ear_pigmentation0.66381666
119MP0001340_abnormal_eyelid_morphology0.65777536
120MP0005408_hypopigmentation0.65603807
121MP0010630_abnormal_cardiac_muscle0.65058609
122MP0000377_abnormal_hair_follicle0.64586143
123MP0001800_abnormal_humoral_immune0.64280104
124MP0002116_abnormal_craniofacial_bone0.63758611
125MP0001545_abnormal_hematopoietic_system0.63692812
126MP0005397_hematopoietic_system_phenotyp0.63692812
127MP0001216_abnormal_epidermal_layer0.63668514
128MP0003122_maternal_imprinting0.63232385
129MP0003699_abnormal_female_reproductive0.62240312
130MP0005075_abnormal_melanosome_morpholog0.61709520
131MP0001191_abnormal_skin_condition0.61250796
132MP0000383_abnormal_hair_follicle0.61226906
133MP0000477_abnormal_intestine_morphology0.60377588

Predicted human phenotypes

RankGene SetZ-score
1Medulloblastoma (HP:0002885)4.39425716
2Chromsome breakage (HP:0040012)3.94522669
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.75434799
4Birth length less than 3rd percentile (HP:0003561)3.32715774
5Ependymoma (HP:0002888)3.29740054
6Patellar aplasia (HP:0006443)3.20162377
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.11999123
8Short 4th metacarpal (HP:0010044)3.11999123
9Abnormality of the labia minora (HP:0012880)3.05919081
10Abnormality of chromosome stability (HP:0003220)3.04987901
11Selective tooth agenesis (HP:0001592)3.02298604
12Acute myeloid leukemia (HP:0004808)2.92370269
13Colon cancer (HP:0003003)2.91113738
14Aplasia/Hypoplasia of the patella (HP:0006498)2.88394442
15Abnormality of the fingertips (HP:0001211)2.84320140
16Ectopic kidney (HP:0000086)2.82987672
17Aplasia/Hypoplasia of the uvula (HP:0010293)2.80046966
18Progressive external ophthalmoplegia (HP:0000590)2.79688521
19Meckel diverticulum (HP:0002245)2.75140471
20Neoplasm of the oral cavity (HP:0100649)2.74025065
21Abnormality of the preputium (HP:0100587)2.71012235
22Papillary thyroid carcinoma (HP:0002895)2.68216799
23Impulsivity (HP:0100710)2.63685549
24Abnormality of the ileum (HP:0001549)2.62756947
25Overlapping toe (HP:0001845)2.59377842
26Abnormal number of incisors (HP:0011064)2.59042841
27Rhabdomyosarcoma (HP:0002859)2.55277888
28Basal cell carcinoma (HP:0002671)2.52853003
29Acute lymphatic leukemia (HP:0006721)2.51071723
30Embryonal renal neoplasm (HP:0011794)2.50535120
31Abnormality of chromosome segregation (HP:0002916)2.49740339
32Nephroblastoma (Wilms tumor) (HP:0002667)2.49180267
33Abnormality of the astrocytes (HP:0100707)2.46447158
34Astrocytoma (HP:0009592)2.46447158
35Pancreatic islet-cell hyperplasia (HP:0004510)2.46277320
36Agnosia (HP:0010524)2.44938793
37Heterotopia (HP:0002282)2.44623974
38Missing ribs (HP:0000921)2.41412989
39Abnormality of the distal phalanx of the thumb (HP:0009617)2.38403651
40Cortical dysplasia (HP:0002539)2.37427196
4111 pairs of ribs (HP:0000878)2.37053955
42IgA deficiency (HP:0002720)2.35422338
43Malignant gastrointestinal tract tumors (HP:0006749)2.34406437
44Gastrointestinal carcinoma (HP:0002672)2.34406437
45Small intestinal stenosis (HP:0012848)2.32130484
46Duodenal stenosis (HP:0100867)2.32130484
47Myelodysplasia (HP:0002863)2.29910668
48Abnormal foot bone ossification (HP:0010675)2.29846000
49Neoplasm of striated muscle (HP:0009728)2.28830368
50Volvulus (HP:0002580)2.28139273
51Glioma (HP:0009733)2.26394661
52Abnormal lung lobation (HP:0002101)2.25816344
53Long eyelashes (HP:0000527)2.24280263
54Amaurosis fugax (HP:0100576)2.22075183
55Cutis marmorata (HP:0000965)2.21899937
56Sloping forehead (HP:0000340)2.19112150
57Absent radius (HP:0003974)2.18867694
58Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.17892644
59Cafe-au-lait spot (HP:0000957)2.16616477
60Aplasia/Hypoplasia of the sternum (HP:0006714)2.16134998
61Short thumb (HP:0009778)2.15228627
62Biliary tract neoplasm (HP:0100574)2.13788621
63Limb hypertonia (HP:0002509)2.13120336
64Supernumerary spleens (HP:0009799)2.12457518
65Leiomyosarcoma (HP:0100243)2.11353920
66Uterine leiomyosarcoma (HP:0002891)2.11353920
67Wide nose (HP:0000445)2.08692046
68Aplasia/hypoplasia of the humerus (HP:0006507)2.08674116
69Breast hypoplasia (HP:0003187)2.08095267
70T lymphocytopenia (HP:0005403)2.08058770
71Squamous cell carcinoma (HP:0002860)2.07741122
72Reticulocytopenia (HP:0001896)2.06893176
73Low anterior hairline (HP:0000294)2.06876631
74Sandal gap (HP:0001852)2.06454872
75Abnormality of the anterior horn cell (HP:0006802)2.06123770
76Degeneration of anterior horn cells (HP:0002398)2.06123770
77Deviation of the thumb (HP:0009603)2.05579247
78Transitional cell carcinoma of the bladder (HP:0006740)2.05163141
79Absent thumb (HP:0009777)2.05091555
80Abnormality of the 4th metacarpal (HP:0010012)2.04759472
81Absent forearm bone (HP:0003953)2.04297790
82Aplasia involving forearm bones (HP:0009822)2.04297790
83Short humerus (HP:0005792)2.03297452
84Neoplasm of the pancreas (HP:0002894)2.03209410
85Flat acetabular roof (HP:0003180)2.02138734
86Embryonal neoplasm (HP:0002898)2.01812370
87Abnormality of the carotid arteries (HP:0005344)2.00571338
88Large earlobe (HP:0009748)1.98839300
89Proximal placement of thumb (HP:0009623)1.97407111
90Increased nuchal translucency (HP:0010880)1.97051857
91Anal stenosis (HP:0002025)1.95388362
92Urethral obstruction (HP:0000796)1.95194709
93Neonatal hypoglycemia (HP:0001998)1.95170804
94Short phalanx of the thumb (HP:0009660)1.95104324
95Abnormality of the duodenum (HP:0002246)1.94765947
96Carpal bone hypoplasia (HP:0001498)1.94466087
97Homocystinuria (HP:0002156)1.92965340
98Abnormality of homocysteine metabolism (HP:0010919)1.92965340
99Truncal obesity (HP:0001956)1.92590433
100Hepatoblastoma (HP:0002884)1.91600732
101Shawl scrotum (HP:0000049)1.91490186
102Microvesicular hepatic steatosis (HP:0001414)1.90466390
103Progressive muscle weakness (HP:0003323)1.89782124
104Obsessive-compulsive behavior (HP:0000722)1.89566448
105Abnormality of T cell number (HP:0011839)1.89133988
106Optic nerve coloboma (HP:0000588)1.88623890
107Macroorchidism (HP:0000053)1.88422509
108Abnormality of the phalanges of the hallux (HP:0010057)1.86189889
109Skull defect (HP:0001362)1.85610694
110Deep philtrum (HP:0002002)1.85391446
111Supernumerary bones of the axial skeleton (HP:0009144)1.85216181
112Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.85019553
113Protruding tongue (HP:0010808)1.84953114
114Subacute progressive viral hepatitis (HP:0006572)1.83325180
115Facial hemangioma (HP:0000329)1.83070619
116Cellular immunodeficiency (HP:0005374)1.82628210
117Broad palm (HP:0001169)1.81322789
118Asymmetry of the thorax (HP:0001555)1.80400746
119Prominent nose (HP:0000448)1.80355585
120Lower limb hyperreflexia (HP:0002395)1.79327457
121Supernumerary ribs (HP:0005815)1.79033475
122Rib fusion (HP:0000902)1.77195033
123Intestinal fistula (HP:0100819)1.76460623
124Capillary hemangiomas (HP:0005306)1.76354195
125Bladder carcinoma (HP:0002862)1.75696236
126Bladder neoplasm (HP:0009725)1.75696236
127Irregular epiphyses (HP:0010582)1.75612714
128Abnormality of DNA repair (HP:0003254)1.75594711
129Chin dimple (HP:0010751)1.75295450
130Bone marrow hypocellularity (HP:0005528)1.74730529
131Metaphyseal cupping (HP:0003021)1.74239276
132Vertebral arch anomaly (HP:0008438)1.74190890
133High pitched voice (HP:0001620)1.73087288
134Aqueductal stenosis (HP:0002410)1.72523071
135Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72425338
136Multiple enchondromatosis (HP:0005701)1.72093316
137Sparse lateral eyebrow (HP:0005338)1.71463774
138Bifid tongue (HP:0010297)1.71182341
139Curly hair (HP:0002212)1.70470863
140Thick eyebrow (HP:0000574)1.68498976
141Ovarian neoplasm (HP:0100615)1.68441984
142IgM deficiency (HP:0002850)1.68403883
143Clubbing of toes (HP:0100760)1.67512865
144Tracheoesophageal fistula (HP:0002575)1.67376500
145Aplastic anemia (HP:0001915)1.67007160
146Broad alveolar ridges (HP:0000187)1.66888853
147Dysmetric saccades (HP:0000641)1.65915610
148Atresia of the external auditory canal (HP:0000413)1.65752087
149Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.65384608
150Trigonocephaly (HP:0000243)1.65155152
151Lymphoma (HP:0002665)1.64740407
152Horseshoe kidney (HP:0000085)1.64430458
153Abnormality of the pancreatic islet cells (HP:0006476)1.64243472
154Abnormality of endocrine pancreas physiology (HP:0012093)1.64243472
155Neoplasm of the colon (HP:0100273)1.63695430
156Cystic hygroma (HP:0000476)1.63370572
157Abnormality of the metopic suture (HP:0005556)1.62412138

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.61647102
2BUB13.46320650
3NEK23.10633685
4SRPK13.05046367
5CDK123.04191077
6TTK2.63487501
7PASK2.56597426
8EEF2K2.56345483
9BRD42.45477705
10WEE12.37617450
11EIF2AK12.35593286
12TSSK62.06179407
13RPS6KB22.01577888
14PLK41.99864367
15ATR1.96822007
16SMG11.95674630
17PLK11.95084381
18ACVR1B1.79261159
19FGFR41.76652429
20MKNK11.72356057
21PBK1.67034304
22CHEK11.65191392
23CAMK1G1.63948494
24AURKB1.62693038
25PLK31.62291599
26FGFR31.62248892
27MKNK21.61494608
28CDK71.60856404
29MAP3K101.53976861
30PNCK1.48818235
31MAP4K11.45977132
32STK41.44226005
33CDK41.43469008
34CHEK21.39416809
35STK101.36309721
36STK31.32912062
37NEK11.32168867
38ATM1.28699703
39CAMK1D1.24844280
40STK38L1.24577590
41MELK1.22770022
42TLK11.21443782
43TGFBR11.19994902
44CLK11.16981582
45DYRK31.15688486
46MAP3K81.14418905
47ZAK1.12292722
48MAP3K141.10172254
49TXK1.08837905
50SGK21.08793191
51CDK21.07630441
52EIF2AK31.07567938
53TAF11.02708682
54VRK11.02333668
55EPHA21.02040610
56TRIB30.99944644
57SGK30.97669664
58PRPF4B0.97632588
59BRSK20.97426264
60PIM10.96979394
61FGFR20.96837197
62MAP3K20.96552202
63CDK10.96349355
64ICK0.95754665
65FLT30.94312602
66CDK30.94217465
67LATS10.89729783
68STK160.87171045
69MAP3K40.85532188
70CCNB10.83707221
71MTOR0.78488891
72ALK0.77069735
73MST40.77021684
74CDK190.76445809
75RPS6KA40.75551330
76AURKA0.74558585
77PKN20.73036579
78RET0.72510860
79CHUK0.72075747
80JAK30.69038478
81WNK10.68877840
82SIK10.67507402
83AKT30.66598957
84YES10.65824695
85NEK60.64190445
86MAP3K60.63522421
87CDK90.63418246
88TESK20.62759429
89SIK30.61997478
90SGK2230.61837138
91SGK4940.61837138
92BRSK10.60306799
93STK240.59715689
94NUAK10.58536583
95CSNK2A20.58365740
96PRKDC0.55896325
97PAK40.55083753
98BRAF0.54930312
99MAPK140.54152860
100NEK90.53417006
101CSNK1D0.52809098
102NME20.51988470
103KSR20.51465724
104NLK0.51343617
105EPHA30.51222895
106FGFR10.49107442
107CDK80.48042318
108GRK60.46538492
109AKT10.46474667
110PRKCI0.46230316
111STK390.46159517
112RPS6KB10.44961463
113GSK3B0.44505165
114ERBB30.44447073
115NME10.44391253
116CDK60.44270900
117TRIM280.42782627
118MARK30.42473908
119CSNK2A10.42000670
120FRK0.40627267
121RPS6KA50.39127619
122BTK0.39045195
123PRKD30.37553020
124IRAK10.37382818
125RAF10.37257944
126CSNK1E0.35612025
127MAPK10.35254198
128MAPK100.35184686
129MET0.34379179
130ITK0.33492018
131LRRK20.32620926
132CSF1R0.32453992
133PTK60.31948511
134AKT20.30989943
135MAPK80.30874067
136MAPK110.29541068

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.90413845
2DNA replication_Homo sapiens_hsa030303.82931379
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.40863974
4Spliceosome_Homo sapiens_hsa030403.33697012
5RNA transport_Homo sapiens_hsa030133.15102716
6RNA polymerase_Homo sapiens_hsa030203.13002456
7Homologous recombination_Homo sapiens_hsa034403.02028508
8Cell cycle_Homo sapiens_hsa041102.94541739
9Nucleotide excision repair_Homo sapiens_hsa034202.69360058
10Base excision repair_Homo sapiens_hsa034102.69189697
11Fanconi anemia pathway_Homo sapiens_hsa034602.67714931
12One carbon pool by folate_Homo sapiens_hsa006702.61898132
13Non-homologous end-joining_Homo sapiens_hsa034502.45816890
14RNA degradation_Homo sapiens_hsa030182.41916882
15* mRNA surveillance pathway_Homo sapiens_hsa030152.40710422
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.28971911
17Basal transcription factors_Homo sapiens_hsa030222.21110987
18Proteasome_Homo sapiens_hsa030501.88127253
19Pyrimidine metabolism_Homo sapiens_hsa002401.85279538
20Ribosome_Homo sapiens_hsa030101.83478787
21p53 signaling pathway_Homo sapiens_hsa041151.62316239
22Primary immunodeficiency_Homo sapiens_hsa053401.44560624
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.43107135
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39437318
25Epstein-Barr virus infection_Homo sapiens_hsa051691.39336531
26Systemic lupus erythematosus_Homo sapiens_hsa053221.29447067
27Herpes simplex infection_Homo sapiens_hsa051681.21460598
28Viral carcinogenesis_Homo sapiens_hsa052031.21351833
29MicroRNAs in cancer_Homo sapiens_hsa052061.14781964
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09229095
31Antigen processing and presentation_Homo sapiens_hsa046121.06080589
32Purine metabolism_Homo sapiens_hsa002301.04823836
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04318542
34HTLV-I infection_Homo sapiens_hsa051661.03384149
35Vitamin digestion and absorption_Homo sapiens_hsa049771.01763377
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00796928
37Oocyte meiosis_Homo sapiens_hsa041140.97113911
38Notch signaling pathway_Homo sapiens_hsa043300.97011649
39Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96829604
40Inositol phosphate metabolism_Homo sapiens_hsa005620.96443230
41Small cell lung cancer_Homo sapiens_hsa052220.92793307
42NF-kappa B signaling pathway_Homo sapiens_hsa040640.90818569
43Basal cell carcinoma_Homo sapiens_hsa052170.89990156
44Colorectal cancer_Homo sapiens_hsa052100.88735630
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87969321
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85986132
47Circadian rhythm_Homo sapiens_hsa047100.84608419
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83920186
49Renal cell carcinoma_Homo sapiens_hsa052110.81044878
50Glioma_Homo sapiens_hsa052140.80500085
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79348459
52ErbB signaling pathway_Homo sapiens_hsa040120.77858499
53Measles_Homo sapiens_hsa051620.77353237
54Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76375976
55Hippo signaling pathway_Homo sapiens_hsa043900.70160412
56Thyroid cancer_Homo sapiens_hsa052160.69721655
57Adherens junction_Homo sapiens_hsa045200.67732511
58Sulfur relay system_Homo sapiens_hsa041220.67576615
59T cell receptor signaling pathway_Homo sapiens_hsa046600.66845585
60Endometrial cancer_Homo sapiens_hsa052130.66788120
61Chronic myeloid leukemia_Homo sapiens_hsa052200.66387877
62TGF-beta signaling pathway_Homo sapiens_hsa043500.64543763
63Hedgehog signaling pathway_Homo sapiens_hsa043400.64336954
64Protein export_Homo sapiens_hsa030600.64277738
65Steroid biosynthesis_Homo sapiens_hsa001000.63844151
66Lysine degradation_Homo sapiens_hsa003100.63182734
67Acute myeloid leukemia_Homo sapiens_hsa052210.62848124
68Hepatitis B_Homo sapiens_hsa051610.62408895
69Viral myocarditis_Homo sapiens_hsa054160.62255482
70Prostate cancer_Homo sapiens_hsa052150.61452053
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61002272
72Insulin signaling pathway_Homo sapiens_hsa049100.60401223
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59936315
74Choline metabolism in cancer_Homo sapiens_hsa052310.58387118
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.57720257
76Hepatitis C_Homo sapiens_hsa051600.57089613
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.56131228
78Apoptosis_Homo sapiens_hsa042100.55154552
79Legionellosis_Homo sapiens_hsa051340.54905249
80Selenocompound metabolism_Homo sapiens_hsa004500.52932851
81Pancreatic cancer_Homo sapiens_hsa052120.48925366
82Pathways in cancer_Homo sapiens_hsa052000.48879253
83Alcoholism_Homo sapiens_hsa050340.48255869
84Influenza A_Homo sapiens_hsa051640.47547889
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.47238059
86AMPK signaling pathway_Homo sapiens_hsa041520.47048437
87Vitamin B6 metabolism_Homo sapiens_hsa007500.46608199
88Non-small cell lung cancer_Homo sapiens_hsa052230.46436310
89mTOR signaling pathway_Homo sapiens_hsa041500.45497310
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.42958550
91Fatty acid biosynthesis_Homo sapiens_hsa000610.42111156
92Hematopoietic cell lineage_Homo sapiens_hsa046400.41774518
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40984001
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.40870558
95FoxO signaling pathway_Homo sapiens_hsa040680.39453123
96Dorso-ventral axis formation_Homo sapiens_hsa043200.38630026
97N-Glycan biosynthesis_Homo sapiens_hsa005100.38397593
98Allograft rejection_Homo sapiens_hsa053300.37779530
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36248635
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34968693
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34510130
102Wnt signaling pathway_Homo sapiens_hsa043100.34345116
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33831596
104B cell receptor signaling pathway_Homo sapiens_hsa046620.33431130
105Insulin resistance_Homo sapiens_hsa049310.33301004
106Propanoate metabolism_Homo sapiens_hsa006400.32497616
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29054848
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.27846297
109Prolactin signaling pathway_Homo sapiens_hsa049170.26041326
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25981466
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.25720182
112Bladder cancer_Homo sapiens_hsa052190.24710758
113HIF-1 signaling pathway_Homo sapiens_hsa040660.24263231
114Biosynthesis of amino acids_Homo sapiens_hsa012300.23285531
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20643342
116Proteoglycans in cancer_Homo sapiens_hsa052050.19846250
117Autoimmune thyroid disease_Homo sapiens_hsa053200.19693150
118Graft-versus-host disease_Homo sapiens_hsa053320.19387949
119Toxoplasmosis_Homo sapiens_hsa051450.19176747
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.19146198
121Pentose phosphate pathway_Homo sapiens_hsa000300.18609825
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18500095
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18321338
124Tight junction_Homo sapiens_hsa045300.17798348

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