WDR34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Defects in this gene are a cause of short-rib thoracic dysplasia 11 with or without polydactyly. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.67173146
2DNA unwinding involved in DNA replication (GO:0006268)5.25034072
3mitotic chromosome condensation (GO:0007076)4.51989827
4COPI coating of Golgi vesicle (GO:0048205)4.29441782
5Golgi transport vesicle coating (GO:0048200)4.29441782
6protein maturation by protein folding (GO:0022417)4.21026231
7nucleobase biosynthetic process (GO:0046112)3.99032086
8establishment of integrated proviral latency (GO:0075713)3.97016243
9telomere maintenance via semi-conservative replication (GO:0032201)3.96421933
10termination of RNA polymerase III transcription (GO:0006386)3.92560905
11transcription elongation from RNA polymerase III promoter (GO:0006385)3.92560905
12purine nucleobase biosynthetic process (GO:0009113)3.91428270
13ribosome biogenesis (GO:0042254)3.90293283
14mitotic sister chromatid segregation (GO:0000070)3.84289209
15nucleobase-containing small molecule interconversion (GO:0015949)3.81931809
16proteasome assembly (GO:0043248)3.79508768
17proline biosynthetic process (GO:0006561)3.78802490
18DNA replication initiation (GO:0006270)3.77422254
19regulation of nuclear cell cycle DNA replication (GO:0033262)3.71555618
20peptidyl-arginine omega-N-methylation (GO:0035247)3.69187549
21DNA strand elongation involved in DNA replication (GO:0006271)3.67206369
22guanosine-containing compound biosynthetic process (GO:1901070)3.64080267
23mitotic nuclear envelope reassembly (GO:0007084)3.63219729
24nuclear envelope reassembly (GO:0031468)3.63219729
25regulation of cilium movement (GO:0003352)3.62192636
26axonemal dynein complex assembly (GO:0070286)3.61503879
27DNA replication checkpoint (GO:0000076)3.61300214
28histone H2A acetylation (GO:0043968)3.56373501
29DNA strand elongation (GO:0022616)3.56370199
30tRNA methylation (GO:0030488)3.52468003
31establishment of viral latency (GO:0019043)3.51245649
32ribosomal small subunit assembly (GO:0000028)3.47030679
33telomere maintenance via recombination (GO:0000722)3.45720045
34formation of translation preinitiation complex (GO:0001731)3.41380118
357-methylguanosine mRNA capping (GO:0006370)3.41218704
36RNA capping (GO:0036260)3.40302104
377-methylguanosine RNA capping (GO:0009452)3.40302104
38RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.39217234
39tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.39217234
40protein retention in ER lumen (GO:0006621)3.38070847
41IMP biosynthetic process (GO:0006188)3.33621530
42pseudouridine synthesis (GO:0001522)3.32469075
43deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.32263883
44cilium or flagellum-dependent cell motility (GO:0001539)3.31638829
45sister chromatid segregation (GO:0000819)3.31057857
46spliceosomal snRNP assembly (GO:0000387)3.30406528
47regulation of translational fidelity (GO:0006450)3.29857762
48rRNA modification (GO:0000154)3.28147655
49regulation of mammary gland epithelial cell proliferation (GO:0033599)3.24753789
50ribonucleoprotein complex biogenesis (GO:0022613)3.23577682
51pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.22179581
52telomere maintenance via telomere lengthening (GO:0010833)3.21060633
53maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.20569490
54maturation of 5.8S rRNA (GO:0000460)3.20058594
55GTP biosynthetic process (GO:0006183)3.18310410
56termination of RNA polymerase I transcription (GO:0006363)3.18143218
57transcription-coupled nucleotide-excision repair (GO:0006283)3.16796596
58CENP-A containing nucleosome assembly (GO:0034080)3.15105824
59regulation of mitotic spindle organization (GO:0060236)3.14722212
60motile cilium assembly (GO:0044458)3.13221125
61regulation of mitochondrial translation (GO:0070129)3.12857525
62microtubule depolymerization (GO:0007019)3.12813342
63intra-S DNA damage checkpoint (GO:0031573)3.12655717
64protein localization to chromosome, centromeric region (GO:0071459)3.12425268
65chromatin remodeling at centromere (GO:0031055)3.10051494
66transcription from RNA polymerase I promoter (GO:0006360)3.09845550
67histone arginine methylation (GO:0034969)3.07320004
68base-excision repair (GO:0006284)3.06539552
69transcription elongation from RNA polymerase I promoter (GO:0006362)3.06413050
70UTP biosynthetic process (GO:0006228)3.05837271
71mitotic recombination (GO:0006312)3.04854015
72CTP metabolic process (GO:0046036)3.04803135
73CTP biosynthetic process (GO:0006241)3.04803135
74pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.04555449
75regulation of spindle organization (GO:0090224)3.02692605
76ribosomal small subunit biogenesis (GO:0042274)3.02278451
77nucleotide-excision repair, DNA gap filling (GO:0006297)3.02201317
78heterochromatin organization (GO:0070828)3.01214937
79pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.99448838
80L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.99257403
81protein deneddylation (GO:0000338)2.97141917
82peptidyl-arginine methylation (GO:0018216)2.96682919
83peptidyl-arginine N-methylation (GO:0035246)2.96682919
84pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.96556651
85cullin deneddylation (GO:0010388)2.96303835
86negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.96200062
87binding of sperm to zona pellucida (GO:0007339)2.95436760
88pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.95223827
89mitotic metaphase plate congression (GO:0007080)2.93470751
90chromosome condensation (GO:0030261)2.93091600
91deoxyribonucleotide biosynthetic process (GO:0009263)2.92162244
92rRNA processing (GO:0006364)2.90555255
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.90041077
94histone exchange (GO:0043486)2.89100545
95DNA-templated transcription, termination (GO:0006353)2.88904032
96regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.88447990
97negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.87850577
98retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.87702077
99sperm-egg recognition (GO:0035036)2.87517943
100anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.86006313
101positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.85322654
102maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.85189484
103rRNA metabolic process (GO:0016072)2.85181840
104DNA replication-independent nucleosome assembly (GO:0006336)2.84556021
105DNA replication-independent nucleosome organization (GO:0034724)2.84556021
106negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.84475411
107piRNA metabolic process (GO:0034587)2.83650493
108spliceosomal tri-snRNP complex assembly (GO:0000244)2.83627952
109regulation of double-strand break repair via homologous recombination (GO:0010569)2.83623355
110tRNA modification (GO:0006400)2.82299499
111DNA synthesis involved in DNA repair (GO:0000731)2.81331093
112pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.80985619
113metallo-sulfur cluster assembly (GO:0031163)2.80756837
114iron-sulfur cluster assembly (GO:0016226)2.80756837
115maturation of SSU-rRNA (GO:0030490)2.80315794
116cellular component biogenesis (GO:0044085)2.79995510
117negative regulation of cell size (GO:0045792)2.79536311
118transcription elongation from RNA polymerase II promoter (GO:0006368)2.79295365
119viral mRNA export from host cell nucleus (GO:0046784)2.78843397
120establishment of apical/basal cell polarity (GO:0035089)2.78632524
121kinetochore organization (GO:0051383)2.76236682
122DNA-templated transcription, elongation (GO:0006354)2.75603727
123pentose-phosphate shunt (GO:0006098)2.75521037
124epithelial cilium movement (GO:0003351)2.74230683
125intraciliary transport (GO:0042073)2.74095968
126DNA double-strand break processing (GO:0000729)2.72900401
127GDP-mannose metabolic process (GO:0019673)2.72205613
128protein localization to kinetochore (GO:0034501)2.72104502
129RNA methylation (GO:0001510)2.70482754
130glucose catabolic process (GO:0006007)2.70235997
131DNA catabolic process, exonucleolytic (GO:0000738)2.69895830
132rRNA methylation (GO:0031167)2.69146324
133peptidyl-histidine modification (GO:0018202)2.68793160
134ncRNA metabolic process (GO:0034660)2.68624905
135UTP metabolic process (GO:0046051)2.67711489
136ribosomal large subunit biogenesis (GO:0042273)2.67604600
137IMP metabolic process (GO:0046040)2.67030086
138metaphase plate congression (GO:0051310)2.66741436
139negative regulation of ligase activity (GO:0051352)2.65796985
140negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.65796985
141mitotic nuclear envelope disassembly (GO:0007077)2.64563328
142folic acid metabolic process (GO:0046655)2.63814849
143pyrimidine nucleotide biosynthetic process (GO:0006221)2.63293845
1442-deoxyribonucleotide biosynthetic process (GO:0009265)2.62998237
145deoxyribose phosphate biosynthetic process (GO:0046385)2.62998237
146transcription initiation from RNA polymerase I promoter (GO:0006361)2.62764300
147ncRNA 3-end processing (GO:0043628)2.62161873
148cilium movement (GO:0003341)2.60214579
149regulation of translational termination (GO:0006449)2.60044526
150tRNA processing (GO:0008033)2.59583364
151protein complex localization (GO:0031503)2.59478578
152kinetochore assembly (GO:0051382)2.58390593
153base-excision repair, AP site formation (GO:0006285)2.58306526
154L-serine metabolic process (GO:0006563)2.58192700
155positive regulation of DNA-dependent DNA replication (GO:2000105)2.55807191
156regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.55197624
157DNA packaging (GO:0006323)2.52811088
158UV protection (GO:0009650)2.48641491
159regulation of cellular amino acid metabolic process (GO:0006521)2.48610631
160negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.47879025
161pyrimidine nucleotide catabolic process (GO:0006244)2.47514041
162negative regulation of mRNA processing (GO:0050686)2.45618852
163NADPH regeneration (GO:0006740)2.44193895
164mitochondrial fusion (GO:0008053)2.43020162

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.33128546
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.11197446
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.81817003
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.63266949
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.48989576
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.24378223
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.18218504
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.17510333
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.16346377
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.12996599
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.09439267
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.97168131
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.94900982
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.79192425
15* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69331947
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.67375252
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.66889173
18* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.52536900
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.47034624
20ZNF263_19887448_ChIP-Seq_K562_Human2.39681819
21YY1_21170310_ChIP-Seq_MESCs_Mouse2.35426681
22* VDR_23849224_ChIP-Seq_CD4+_Human2.34839508
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.30052138
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27516026
25XRN2_22483619_ChIP-Seq_HELA_Human2.17782997
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12104464
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10341365
28* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.04457452
29FOXP3_21729870_ChIP-Seq_TREG_Human2.03681995
30GABP_19822575_ChIP-Seq_HepG2_Human2.03467252
31E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02833211
32* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.02075117
33* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99804764
34* SRF_21415370_ChIP-Seq_HL-1_Mouse1.98003219
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95256705
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.93759953
37DCP1A_22483619_ChIP-Seq_HELA_Human1.92884039
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89144424
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84393350
40* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81604182
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81067353
42TTF2_22483619_ChIP-Seq_HELA_Human1.81011816
43* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78333048
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.76197874
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.75757209
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74960925
47RACK7_27058665_Chip-Seq_MCF-7_Human1.74112858
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72938999
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.70006570
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.69317633
51LXR_22292898_ChIP-Seq_THP-1_Human1.66819940
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62784152
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59369225
54VDR_21846776_ChIP-Seq_THP-1_Human1.58814415
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58450693
56* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.56405975
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53540081
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53517873
59* TET1_21451524_ChIP-Seq_MESCs_Mouse1.49927940
60FOXM1_23109430_ChIP-Seq_U2OS_Human1.47762846
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.46599406
62* CIITA_25753668_ChIP-Seq_RAJI_Human1.46239720
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.46044278
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.45997047
65* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45828748
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.45787083
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45208201
68ELK1_19687146_ChIP-ChIP_HELA_Human1.45170496
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.44044548
70* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44034496
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43880782
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41134780
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.40727852
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38973019
75MYC_22102868_ChIP-Seq_BL_Human1.38809284
76HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.37782051
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37731137
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36900797
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36438763
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.35125136
81* P68_20966046_ChIP-Seq_HELA_Human1.29994794
82* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29560638
83* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26544012
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22263648
85KDM5A_27292631_Chip-Seq_BREAST_Human1.21941046
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17593769
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17402603
88ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15809232
89TP63_19390658_ChIP-ChIP_HaCaT_Human1.15540598
90HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15445958
91KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.14766186
92ATF3_27146783_Chip-Seq_COLON_Human1.13390637
93* FOXP1_21924763_ChIP-Seq_HESCs_Human1.13311988
94* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12522038
95* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12042987
96CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09745639
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08927406
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08760481
99EZH2_22144423_ChIP-Seq_EOC_Human1.08606252
100PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06775362
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06628200
102KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05506167
103* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.05297321
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04962153
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04590839
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02770348
107SMC4_20622854_ChIP-Seq_HELA_Human1.02188970
108SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02022356
109SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01224384
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01186397
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98480762
112SA1_27219007_Chip-Seq_ERYTHROID_Human0.97655755
113UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97552805
114* ELF1_20517297_ChIP-Seq_JURKAT_Human0.96488669
115E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96014896
116GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94971099
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94261387
118YY1_22570637_ChIP-Seq_MALME-3M_Human0.94059022
119* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93783952
120CTCF_26484167_Chip-Seq_Bcells_Mouse0.92839853
121OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92743673
122NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91123995
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90176850
124CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89063409
125IRF1_19129219_ChIP-ChIP_H3396_Human0.88576476
126NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.86324005
127CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86008780
128SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.84360087
129STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83399795
130TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.83144129
131CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82081038
132DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78049196
133AR_21909140_ChIP-Seq_LNCAP_Human0.77241104
134MYC_18940864_ChIP-ChIP_HL60_Human0.76900979
135KLF4_18555785_ChIP-Seq_MESCs_Mouse0.75114470
136FLI1_27457419_Chip-Seq_LIVER_Mouse0.74746276
137FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74724235
138GATA1_26923725_Chip-Seq_HPCs_Mouse0.73760432
139EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.73535042

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.03972012
2MP0008058_abnormal_DNA_repair3.78609593
3MP0010094_abnormal_chromosome_stability3.57226196
4MP0006292_abnormal_olfactory_placode3.53187111
5MP0008057_abnormal_DNA_replication3.50220079
6MP0003111_abnormal_nucleus_morphology3.19469716
7MP0008877_abnormal_DNA_methylation2.95718440
8MP0010234_abnormal_vibrissa_follicle2.75202664
9MP0003705_abnormal_hypodermis_morpholog2.69374166
10MP0002877_abnormal_melanocyte_morpholog2.58194757
11MP0004957_abnormal_blastocyst_morpholog2.54439524
12MP0003077_abnormal_cell_cycle2.50569652
13MP0005410_abnormal_fertilization2.47983333
14MP0008007_abnormal_cellular_replicative2.39810676
15MP0001986_abnormal_taste_sensitivity2.26782815
16MP0008789_abnormal_olfactory_epithelium2.21951824
17MP0003786_premature_aging2.19354666
18MP0000678_abnormal_parathyroid_gland2.15252518
19MP0005501_abnormal_skin_physiology2.09653751
20MP0005394_taste/olfaction_phenotype2.04355668
21MP0005499_abnormal_olfactory_system2.04355668
22MP0001984_abnormal_olfaction2.03345956
23MP0001188_hyperpigmentation1.96873700
24MP0001346_abnormal_lacrimal_gland1.95954682
25MP0003123_paternal_imprinting1.86503111
26MP0005646_abnormal_pituitary_gland1.83048739
27MP0002249_abnormal_larynx_morphology1.80956552
28MP0005623_abnormal_meninges_morphology1.79143644
29MP0002796_impaired_skin_barrier1.77492275
30MP0008932_abnormal_embryonic_tissue1.76804888
31MP0002210_abnormal_sex_determination1.74839291
32MP0001929_abnormal_gametogenesis1.74608011
33MP0002638_abnormal_pupillary_reflex1.70306381
34MP0002160_abnormal_reproductive_system1.69885467
35MP0001849_ear_inflammation1.69228565
36MP0003698_abnormal_male_reproductive1.68936134
37MP0005645_abnormal_hypothalamus_physiol1.68577664
38MP0004133_heterotaxia1.66612263
39MP0001529_abnormal_vocalization1.64476916
40MP0004233_abnormal_muscle_weight1.63121299
41MP0005076_abnormal_cell_differentiation1.60934116
42MP0000566_synostosis1.57714905
43MP0002653_abnormal_ependyma_morphology1.49078021
44MP0001145_abnormal_male_reproductive1.46767894
45MP0002396_abnormal_hematopoietic_system1.43055509
46MP0004858_abnormal_nervous_system1.43023148
47MP0003121_genomic_imprinting1.39885192
48MP0005451_abnormal_body_composition1.38558274
49MP0002098_abnormal_vibrissa_morphology1.36677873
50MP0004264_abnormal_extraembryonic_tissu1.35454125
51MP0003806_abnormal_nucleotide_metabolis1.35452162
52MP0001672_abnormal_embryogenesis/_devel1.32243055
53MP0005380_embryogenesis_phenotype1.32243055
54MP0002938_white_spotting1.32110547
55MP0003718_maternal_effect1.30820266
56MP0002132_abnormal_respiratory_system1.29108092
57MP0000049_abnormal_middle_ear1.28297676
58MP0001697_abnormal_embryo_size1.27567206
59MP0000653_abnormal_sex_gland1.26877970
60MP0008995_early_reproductive_senescence1.26774531
61MP0010386_abnormal_urinary_bladder1.25654128
62MP0005257_abnormal_intraocular_pressure1.24496418
63MP0002751_abnormal_autonomic_nervous1.24373003
64MP0005083_abnormal_biliary_tract1.23175510
65MP0004185_abnormal_adipocyte_glucose1.22365885
66MP0003566_abnormal_cell_adhesion1.20905212
67MP0005058_abnormal_lysosome_morphology1.20487321
68MP0003787_abnormal_imprinting1.20259086
69MP0008260_abnormal_autophagy1.20155036
70MP0003122_maternal_imprinting1.19978219
71MP0005389_reproductive_system_phenotype1.19442553
72MP0009379_abnormal_foot_pigmentation1.18039102
73MP0000467_abnormal_esophagus_morphology1.13495781
74MP0000762_abnormal_tongue_morphology1.12751232
75MP0003984_embryonic_growth_retardation1.12291187
76MP0003453_abnormal_keratinocyte_physiol1.11269101
77MP0002060_abnormal_skin_morphology1.08946421
78MP0000003_abnormal_adipose_tissue1.08402932
79MP0003941_abnormal_skin_development1.08179814
80MP0000015_abnormal_ear_pigmentation1.07787255
81MP0001881_abnormal_mammary_gland1.07756462
82MP0001727_abnormal_embryo_implantation1.06271452
83MP0003890_abnormal_embryonic-extraembry1.05173690
84MP0000313_abnormal_cell_death1.05039156
85MP0005423_abnormal_somatic_nervous1.04873909
86MP0005174_abnormal_tail_pigmentation1.04843229
87MP0002088_abnormal_embryonic_growth/wei1.04450766
88MP0005075_abnormal_melanosome_morpholog1.03467834
89MP0002084_abnormal_developmental_patter1.02555176
90MP0000751_myopathy1.02289116
91MP0010352_gastrointestinal_tract_polyps1.02111428
92MP0002111_abnormal_tail_morphology1.01703849
93MP0000350_abnormal_cell_proliferation0.98969486
94MP0000490_abnormal_crypts_of0.98506370
95MP0006072_abnormal_retinal_apoptosis0.98286872
96MP0009053_abnormal_anal_canal0.96389729
97MP0000681_abnormal_thyroid_gland0.96037675
98MP0002161_abnormal_fertility/fecundity0.96024061
99MP0009672_abnormal_birth_weight0.95377071
100MP0000631_abnormal_neuroendocrine_gland0.95061203
101MP0000579_abnormal_nail_morphology0.94973274
102MP0002697_abnormal_eye_size0.92915485
103MP0000462_abnormal_digestive_system0.90393761
104MP0004197_abnormal_fetal_growth/weight/0.90000923
105MP0010771_integument_phenotype0.89871826
106MP0001216_abnormal_epidermal_layer0.89476309
107MP0001764_abnormal_homeostasis0.89393148
108MP0002557_abnormal_social/conspecific_i0.89329500
109MP0002095_abnormal_skin_pigmentation0.89049273
110MP0002876_abnormal_thyroid_physiology0.88483107
111MP0001293_anophthalmia0.88211385
112MP0006035_abnormal_mitochondrial_morpho0.87459562
113MP0001730_embryonic_growth_arrest0.87062866
114MP0002092_abnormal_eye_morphology0.87011942
115MP0003136_yellow_coat_color0.86879840
116MP0003183_abnormal_peptide_metabolism0.86478143
117MP0000627_abnormal_mammary_gland0.86216292
118MP0004859_abnormal_synaptic_plasticity0.85321710
119MP0001905_abnormal_dopamine_level0.85125196
120MP0002184_abnormal_innervation0.84684815
121MP0005379_endocrine/exocrine_gland_phen0.83969674
122MP0010030_abnormal_orbit_morphology0.83862453
123MP0005384_cellular_phenotype0.82883529
124MP0001119_abnormal_female_reproductive0.82799514
125MP0002086_abnormal_extraembryonic_tissu0.82787297
126MP0006036_abnormal_mitochondrial_physio0.82154797
127MP0002019_abnormal_tumor_incidence0.81977500
128MP0000358_abnormal_cell_content/0.81657491
129MP0006276_abnormal_autonomic_nervous0.81626285
130MP0003942_abnormal_urinary_system0.79963481
131MP0005621_abnormal_cell_physiology0.79446192
132MP0003186_abnormal_redox_activity0.79084382
133MP0003937_abnormal_limbs/digits/tail_de0.78690612
134MP0005330_cardiomyopathy0.78044544
135MP0002163_abnormal_gland_morphology0.75898347
136MP0005248_abnormal_Harderian_gland0.75164849
137MP0000534_abnormal_ureter_morphology0.75138299
138MP0000537_abnormal_urethra_morphology0.74757060
139MP0001186_pigmentation_phenotype0.74220753
140MP0003880_abnormal_central_pattern0.74135110
141MP0002089_abnormal_postnatal_growth/wei0.73801336
142MP0000377_abnormal_hair_follicle0.72964779
143MP0002102_abnormal_ear_morphology0.72541471
144MP0009278_abnormal_bone_marrow0.72334446
145MP0000372_irregular_coat_pigmentation0.71798775
146MP0005253_abnormal_eye_physiology0.71685241
147MP0001348_abnormal_lacrimal_gland0.70896594
148MP0003385_abnormal_body_wall0.70693747
149MP0002085_abnormal_embryonic_tissue0.70368258
150MP0003879_abnormal_hair_cell0.70300712
151MP0004808_abnormal_hematopoietic_stem0.69912329
152MP0004782_abnormal_surfactant_physiolog0.69820884
153MP0001919_abnormal_reproductive_system0.69786105
154MP0002080_prenatal_lethality0.69685170
155MP0003119_abnormal_digestive_system0.69243924
156MP0004272_abnormal_basement_membrane0.68744134
157MP0002572_abnormal_emotion/affect_behav0.68351680
158MP0000026_abnormal_inner_ear0.68080104
159MP0002075_abnormal_coat/hair_pigmentati0.66657585
160MP0003861_abnormal_nervous_system0.65998668
161MP0003938_abnormal_ear_development0.65929606
162MP0002735_abnormal_chemical_nociception0.63611814
163MP0005084_abnormal_gallbladder_morpholo0.63245156
164MP0003315_abnormal_perineum_morphology0.63196721
165MP0002063_abnormal_learning/memory/cond0.62787417
166MP0003635_abnormal_synaptic_transmissio0.62317579

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.22361588
2Aplasia/Hypoplasia of the sacrum (HP:0008517)3.94572915
3Birth length less than 3rd percentile (HP:0003561)3.82606383
4Abnormal respiratory epithelium morphology (HP:0012253)3.65102607
5Abnormal respiratory motile cilium morphology (HP:0005938)3.65102607
6Hyperacusis (HP:0010780)3.64802289
7Dynein arm defect of respiratory motile cilia (HP:0012255)3.59975419
8Absent/shortened dynein arms (HP:0200106)3.59975419
9Pancreatic fibrosis (HP:0100732)3.59475283
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.47355975
11True hermaphroditism (HP:0010459)3.35606465
12Chromsome breakage (HP:0040012)3.27203904
13Abnormal respiratory motile cilium physiology (HP:0012261)3.22867265
14Broad distal phalanx of finger (HP:0009836)3.16627009
15Abnormality of the distal phalanges of the toes (HP:0010182)3.14469746
16Pancreatic cysts (HP:0001737)3.09875836
17Type I transferrin isoform profile (HP:0003642)3.05147913
18Abnormality of the anterior horn cell (HP:0006802)2.97808153
19Degeneration of anterior horn cells (HP:0002398)2.97808153
2011 pairs of ribs (HP:0000878)2.94075918
21Chronic bronchitis (HP:0004469)2.93416867
22Rhinitis (HP:0012384)2.93023633
23Hypoplasia of the capital femoral epiphysis (HP:0003090)2.91104621
24Abnormal ciliary motility (HP:0012262)2.84952047
25Abnormality of midbrain morphology (HP:0002418)2.83038651
26Molar tooth sign on MRI (HP:0002419)2.83038651
27Aplastic anemia (HP:0001915)2.80630279
28Medial flaring of the eyebrow (HP:0010747)2.79139926
29Short nail (HP:0001799)2.71451672
30Abnormal number of erythroid precursors (HP:0012131)2.69902648
31Gait imbalance (HP:0002141)2.69677548
32Trismus (HP:0000211)2.67474986
33Abnormality of the umbilical cord (HP:0010881)2.66182474
34Nephrogenic diabetes insipidus (HP:0009806)2.65325256
35Abnormality of cells of the erythroid lineage (HP:0012130)2.64667927
36Testicular atrophy (HP:0000029)2.60207418
37Congenital primary aphakia (HP:0007707)2.59167749
38Ragged-red muscle fibers (HP:0003200)2.58438619
39Abnormality of the preputium (HP:0100587)2.56344445
40Cholecystitis (HP:0001082)2.55467679
41Abnormal gallbladder physiology (HP:0012438)2.55467679
42Upper limb amyotrophy (HP:0009129)2.54754260
43Distal upper limb amyotrophy (HP:0007149)2.54754260
44Meckel diverticulum (HP:0002245)2.53393250
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.47977600
46Absent epiphyses (HP:0010577)2.47533809
47Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.47533809
48Carpal bone hypoplasia (HP:0001498)2.46322884
49Impulsivity (HP:0100710)2.46177681
50Cerebral hypomyelination (HP:0006808)2.44118044
51Abnormality of the ileum (HP:0001549)2.41239072
52Patellar aplasia (HP:0006443)2.39530285
53Breast hypoplasia (HP:0003187)2.38852663
54Distal lower limb muscle weakness (HP:0009053)2.35420130
55Hand muscle atrophy (HP:0009130)2.35056899
56Abnormality of chromosome stability (HP:0003220)2.34998959
57Atelectasis (HP:0100750)2.33897007
58Proximal placement of thumb (HP:0009623)2.33765921
59Microvesicular hepatic steatosis (HP:0001414)2.32285852
60* Facial cleft (HP:0002006)2.31159650
61Male infertility (HP:0003251)2.30976677
62Insomnia (HP:0100785)2.30725987
63Nephronophthisis (HP:0000090)2.29816304
64Type 2 muscle fiber atrophy (HP:0003554)2.28442843
65Abnormality of glycolysis (HP:0004366)2.27920606
66Supernumerary spleens (HP:0009799)2.26540580
67Absent rod-and cone-mediated responses on ERG (HP:0007688)2.23953348
68Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.23600011
69Abnormal protein N-linked glycosylation (HP:0012347)2.23600011
70Abnormal protein glycosylation (HP:0012346)2.23600011
71Abnormal glycosylation (HP:0012345)2.23600011
72Nasal polyposis (HP:0100582)2.23530043
733-Methylglutaconic aciduria (HP:0003535)2.21829184
74Deviation of the thumb (HP:0009603)2.21334549
75Aplasia/Hypoplasia of the patella (HP:0006498)2.20249442
76Ulnar bowing (HP:0003031)2.19927455
77Down-sloping shoulders (HP:0200021)2.19291432
78Reticulocytopenia (HP:0001896)2.18394523
79Occipital encephalocele (HP:0002085)2.17842261
80Abnormal spermatogenesis (HP:0008669)2.17317524
81Rough bone trabeculation (HP:0100670)2.16215534
82Hypokinesia (HP:0002375)2.15830608
83Optic nerve coloboma (HP:0000588)2.15356234
84Broad face (HP:0000283)2.12077430
85Premature rupture of membranes (HP:0001788)2.11049309
86Achilles tendon contracture (HP:0001771)2.10529388
87Vertebral compression fractures (HP:0002953)2.10472906
88Stridor (HP:0010307)2.08617071
89Sloping forehead (HP:0000340)2.06599830
90Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.06597742
91Overriding aorta (HP:0002623)2.04703978
92Spinal cord compression (HP:0002176)2.03982739
93Bone marrow hypocellularity (HP:0005528)2.02968406
94Atrophy/Degeneration involving motor neurons (HP:0007373)2.02942421
95Microglossia (HP:0000171)2.01792036
96Severe visual impairment (HP:0001141)2.01371285
97Horseshoe kidney (HP:0000085)2.00805234
98Muscle fiber atrophy (HP:0100295)2.00621026
99Long palpebral fissure (HP:0000637)2.00554121
100Flattened epiphyses (HP:0003071)1.99370455
101Unsteady gait (HP:0002317)1.97452652
102Single umbilical artery (HP:0001195)1.97127497
103Abnormality of the fetal cardiovascular system (HP:0010948)1.97127497
104Abnormal umbilical cord blood vessels (HP:0011403)1.97127497
105Oral leukoplakia (HP:0002745)1.96962573
106Abnormal trabecular bone morphology (HP:0100671)1.96838364
107Increased nuchal translucency (HP:0010880)1.96655382
108Abnormality of DNA repair (HP:0003254)1.96351859
109Poor coordination (HP:0002370)1.95787487
110* Median cleft lip (HP:0000161)1.95591773
111Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92620821
112Abnormality of alanine metabolism (HP:0010916)1.92620821
113Hyperalaninemia (HP:0003348)1.92620821
114Aganglionic megacolon (HP:0002251)1.91898467
115Abnormalities of placenta or umbilical cord (HP:0001194)1.91361252
116Self-mutilation (HP:0000742)1.90931962
117Increased serum pyruvate (HP:0003542)1.88914853
118Anencephaly (HP:0002323)1.88336600
119Entropion (HP:0000621)1.88142159
120Pancytopenia (HP:0001876)1.88114534
121Abnormality of reticulocytes (HP:0004312)1.87390675
122Aplasia/hypoplasia of the uterus (HP:0008684)1.86815393
123Absent thumb (HP:0009777)1.86125896
124Decreased activity of mitochondrial respiratory chain (HP:0008972)1.85673219
125Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.85673219
126Septate vagina (HP:0001153)1.85442164
127Secondary amenorrhea (HP:0000869)1.82573586
128Poikiloderma (HP:0001029)1.82071018
129* Preaxial hand polydactyly (HP:0001177)1.82003421
130Small intestinal stenosis (HP:0012848)1.81642621
131Duodenal stenosis (HP:0100867)1.81642621
132* Postaxial foot polydactyly (HP:0001830)1.81106822
133Abnormal rod and cone electroretinograms (HP:0008323)1.79628383
134Elfin facies (HP:0004428)1.78989576
135Abnormality of the labia minora (HP:0012880)1.78962972
136Broad foot (HP:0001769)1.78378425
137Microretrognathia (HP:0000308)1.76652520
138Sclerocornea (HP:0000647)1.76216501
139Selective tooth agenesis (HP:0001592)1.76162815
140Pili torti (HP:0003777)1.76002298
141Abnormal hair whorl (HP:0010721)1.75916850
142Oligohydramnios (HP:0001562)1.75560091
143Gout (HP:0001997)1.75266936
144Aplasia/Hypoplasia of the tongue (HP:0010295)1.74920291
145Diaphragmatic weakness (HP:0009113)1.74297791
146Elbow flexion contracture (HP:0002987)1.74043483
147Myelodysplasia (HP:0002863)1.73777683
148Progressive muscle weakness (HP:0003323)1.73533287
149Cystic liver disease (HP:0006706)1.73305605
150Squamous cell carcinoma (HP:0002860)1.72316228
151Patellar dislocation (HP:0002999)1.71657478
152Abnormality of the Achilles tendon (HP:0005109)1.71486435
153Medulloblastoma (HP:0002885)1.71226992
154Cleft eyelid (HP:0000625)1.70817034
155Myopathic facies (HP:0002058)1.69757522
156Bronchiectasis (HP:0002110)1.69168709
157Abnormality of the nasal mucosa (HP:0000433)1.68898245
158Tubulointerstitial nephritis (HP:0001970)1.68477618
159Intestinal atresia (HP:0011100)1.68398042
160Sparse eyelashes (HP:0000653)1.67867796
161Colon cancer (HP:0003003)1.67613114
162Abnormal mitochondria in muscle tissue (HP:0008316)1.65666352
163Flat acetabular roof (HP:0003180)1.65360162
164Distal lower limb amyotrophy (HP:0008944)1.65041106
165Reticulocytosis (HP:0001923)1.64341941
166High anterior hairline (HP:0009890)1.63140486
167Abnormal number of incisors (HP:0011064)1.62403815
168Renal duplication (HP:0000075)1.61824136
169Hepatocellular necrosis (HP:0001404)1.57817731
170Pseudobulbar signs (HP:0002200)1.56727311
171Fasciculations (HP:0002380)1.54667161
172Atresia of the external auditory canal (HP:0000413)1.54608684
173Limb-girdle muscle atrophy (HP:0003797)1.54465818
174Hyperthyroidism (HP:0000836)1.54092080

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.91912092
2STK163.78505100
3TRIB33.39354531
4WEE13.16784167
5VRK23.13893074
6SMG13.00009470
7TSSK62.62582874
8EIF2AK12.58087091
9TESK22.56618712
10MST1R2.55535285
11PLK42.48829060
12VRK12.38786835
13SRPK12.30779666
14ZAK2.27979095
15DYRK32.22433425
16MARK12.10533936
17EIF2AK32.04497354
18CCNB12.04195761
19SCYL22.00653610
20PBK1.93135567
21SIK11.89838620
22ACVR1B1.88250392
23PNCK1.87465967
24PINK11.80704526
25PASK1.77229238
26PAK41.75901335
27ICK1.75308080
28IRAK31.74378146
29BRSK11.71292740
30BRSK21.66310519
31MAPK151.62123081
32PLK31.57773213
33CDC71.57522535
34LIMK11.57199981
35WNK31.50547314
36PLK11.50520586
37ATR1.50446093
38PKN21.45676828
39TTK1.43136910
40EEF2K1.40797171
41MAP2K71.39105312
42TESK11.35109236
43ERBB31.35074610
44AKT31.30981011
45PIM21.30385052
46PDK31.29847036
47PDK41.29847036
48NME21.29329658
49MKNK11.27535814
50NEK21.27082647
51BCKDK1.26149103
52EPHA21.24610884
53KDR1.21772963
54AURKA1.21451501
55MET1.20344776
56EIF2AK21.20148459
57DYRK21.17430357
58CHEK21.13514730
59MKNK21.12977880
60TLK11.12160307
61BRAF1.12107886
62DAPK11.11281844
63IRAK41.10213093
64MAPK131.08049990
65MAP3K121.04644764
66ARAF1.04584128
67CDK71.03984828
68PRKD31.03878679
69PTK21.00581944
70MAP3K110.96873863
71LMTK20.96574258
72MAPKAPK30.96379341
73BMPR1B0.94951341
74ILK0.93639610
75TAOK20.91993956
76MAP3K80.91077908
77ABL20.90347335
78MAP2K60.90334260
79PRPF4B0.89557198
80MAP3K100.87909797
81LRRK20.87348173
82ERN10.85964057
83CDK80.84193924
84AURKB0.84125480
85FLT30.80873188
86YES10.77259212
87STK38L0.77023851
88CDK120.76084362
89PRKCI0.75909341
90SIK30.73454310
91CHEK10.73007306
92PDK20.71731347
93CSNK1G30.69782474
94RPS6KB20.69074010
95PTK60.67069410
96ADRBK20.66841275
97AKT20.65813273
98CSNK2A10.65398964
99MAP2K20.63429527
100RPS6KB10.63290010
101MTOR0.62861031
102NTRK20.60204669
103MUSK0.60108607
104ATM0.59843740
105STK40.59210427
106BMPR20.58589057
107CASK0.56188782
108CSNK1A1L0.55788008
109CSNK2A20.55732635
110CDK40.55356364
111TTN0.52428720
112PRKCG0.51175010
113CDK11A0.51075772
114CDK20.49639376
115TEC0.49000647
116CAMKK20.48252313
117MST40.48222527
118CDK150.47772202
119NEK10.47227840
120MAPK110.47147351
121CDK180.45951776
122CDK140.45868000
123TGFBR10.45436993
124BMX0.45373948
125UHMK10.44405787
126STK240.44133592
127CAMK2G0.42760387
128CDK190.41967187
129IRAK10.41921577
130STK100.41171253
131NME10.41037696
132MAP3K30.39793413
133IRAK20.39682853
134MINK10.39664933
135RPS6KA20.38712655
136TAF10.38664754
137CDK10.38616589
138CDK90.37401987
139ERBB40.36341860
140RPS6KA40.35376853
141EPHA40.35030632
142MAPKAPK50.34488037
143NTRK10.33524775
144BTK0.33250473
145PIK3CG0.32485889
146PAK10.30450937
147DYRK1A0.30146591
148SGK20.29015405
149CSNK1G10.28993264
150NEK60.28419251

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.25663887
2RNA polymerase_Homo sapiens_hsa030203.91381550
3Mismatch repair_Homo sapiens_hsa034303.65531168
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.26029372
5Proteasome_Homo sapiens_hsa030503.16501423
6Homologous recombination_Homo sapiens_hsa034402.99447068
7Pyrimidine metabolism_Homo sapiens_hsa002402.93621507
8Ribosome_Homo sapiens_hsa030102.90175204
9Spliceosome_Homo sapiens_hsa030402.84824565
10Base excision repair_Homo sapiens_hsa034102.79860376
11RNA transport_Homo sapiens_hsa030132.64866290
12Fanconi anemia pathway_Homo sapiens_hsa034602.64319756
13Nucleotide excision repair_Homo sapiens_hsa034202.62092389
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40753905
15Biosynthesis of amino acids_Homo sapiens_hsa012302.26973157
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.23208266
17Basal transcription factors_Homo sapiens_hsa030222.19150287
18Purine metabolism_Homo sapiens_hsa002302.00642445
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.00429721
20Protein export_Homo sapiens_hsa030601.99443873
21Cell cycle_Homo sapiens_hsa041101.95857998
22Non-homologous end-joining_Homo sapiens_hsa034501.94145970
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.76229528
24Vitamin B6 metabolism_Homo sapiens_hsa007501.67564290
25RNA degradation_Homo sapiens_hsa030181.61426626
26Carbon metabolism_Homo sapiens_hsa012001.54033227
27mRNA surveillance pathway_Homo sapiens_hsa030151.49473319
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42640498
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.37196099
30Regulation of autophagy_Homo sapiens_hsa041401.34769750
31Huntingtons disease_Homo sapiens_hsa050161.34284075
32Phenylalanine metabolism_Homo sapiens_hsa003601.30199273
33One carbon pool by folate_Homo sapiens_hsa006701.26397784
34N-Glycan biosynthesis_Homo sapiens_hsa005101.22733349
35Fatty acid elongation_Homo sapiens_hsa000621.21216674
36Pyruvate metabolism_Homo sapiens_hsa006201.11853318
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11741831
38p53 signaling pathway_Homo sapiens_hsa041151.09412724
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.05147250
40Bladder cancer_Homo sapiens_hsa052191.04253515
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03353673
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00124492
43Parkinsons disease_Homo sapiens_hsa050121.00101719
44Epstein-Barr virus infection_Homo sapiens_hsa051690.99172376
45Oxidative phosphorylation_Homo sapiens_hsa001900.93471068
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92137677
47Sulfur relay system_Homo sapiens_hsa041220.90408743
48Oocyte meiosis_Homo sapiens_hsa041140.87004417
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85597395
50Tyrosine metabolism_Homo sapiens_hsa003500.84963816
51Folate biosynthesis_Homo sapiens_hsa007900.79695256
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77337415
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77114350
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.73104094
55Caffeine metabolism_Homo sapiens_hsa002320.72904062
56Steroid biosynthesis_Homo sapiens_hsa001000.72140943
57Taste transduction_Homo sapiens_hsa047420.71268735
58Alcoholism_Homo sapiens_hsa050340.70309768
59Arachidonic acid metabolism_Homo sapiens_hsa005900.69170914
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67575699
61Other glycan degradation_Homo sapiens_hsa005110.66543252
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66084165
63Olfactory transduction_Homo sapiens_hsa047400.65661327
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65645624
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64997351
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64697960
67Nicotine addiction_Homo sapiens_hsa050330.62831079
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.62593358
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62502122
70Synaptic vesicle cycle_Homo sapiens_hsa047210.62296647
71Chronic myeloid leukemia_Homo sapiens_hsa052200.59958437
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59493229
73Phototransduction_Homo sapiens_hsa047440.58417047
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57393752
75Arginine and proline metabolism_Homo sapiens_hsa003300.57087080
76Hippo signaling pathway_Homo sapiens_hsa043900.56464799
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.55252536
78Fructose and mannose metabolism_Homo sapiens_hsa000510.53976818
79Insulin secretion_Homo sapiens_hsa049110.53952070
80Amphetamine addiction_Homo sapiens_hsa050310.52662020
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51933686
82Arginine biosynthesis_Homo sapiens_hsa002200.50539160
83Small cell lung cancer_Homo sapiens_hsa052220.49567719
84Galactose metabolism_Homo sapiens_hsa000520.49544468
85Herpes simplex infection_Homo sapiens_hsa051680.47055523
86Non-small cell lung cancer_Homo sapiens_hsa052230.45952784
87Alzheimers disease_Homo sapiens_hsa050100.44392707
88Pancreatic cancer_Homo sapiens_hsa052120.44219091
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43056529
90Systemic lupus erythematosus_Homo sapiens_hsa053220.42988312
91Lysine degradation_Homo sapiens_hsa003100.42973771
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42434851
93Type I diabetes mellitus_Homo sapiens_hsa049400.42150551
94Legionellosis_Homo sapiens_hsa051340.41728293
95Pentose phosphate pathway_Homo sapiens_hsa000300.41684443
96Metabolic pathways_Homo sapiens_hsa011000.41165797
97Vibrio cholerae infection_Homo sapiens_hsa051100.39747527
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38958466
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38787832
100Collecting duct acid secretion_Homo sapiens_hsa049660.38694272
101Selenocompound metabolism_Homo sapiens_hsa004500.38470816
102HTLV-I infection_Homo sapiens_hsa051660.37627789
103Tight junction_Homo sapiens_hsa045300.37581733
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37124202
105Glutathione metabolism_Homo sapiens_hsa004800.36423058
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35448789
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35444712
108Shigellosis_Homo sapiens_hsa051310.35253264
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34759756
110AMPK signaling pathway_Homo sapiens_hsa041520.34051186
111Apoptosis_Homo sapiens_hsa042100.33399860
112Viral carcinogenesis_Homo sapiens_hsa052030.32741607
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32330808
114Linoleic acid metabolism_Homo sapiens_hsa005910.31035663
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30593676
116Sphingolipid metabolism_Homo sapiens_hsa006000.29588336
117Fatty acid metabolism_Homo sapiens_hsa012120.29002629
118Endometrial cancer_Homo sapiens_hsa052130.28205454
119Circadian rhythm_Homo sapiens_hsa047100.27874094
120Wnt signaling pathway_Homo sapiens_hsa043100.26861802
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26667756
122beta-Alanine metabolism_Homo sapiens_hsa004100.25435964
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25186357
124Circadian entrainment_Homo sapiens_hsa047130.24308564
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.23551721
126Hedgehog signaling pathway_Homo sapiens_hsa043400.22507754
127MicroRNAs in cancer_Homo sapiens_hsa052060.21167165
128Antigen processing and presentation_Homo sapiens_hsa046120.20468459
129Insulin signaling pathway_Homo sapiens_hsa049100.20367797
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.19210686
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18373883
132Morphine addiction_Homo sapiens_hsa050320.17811235
133Cocaine addiction_Homo sapiens_hsa050300.16346458
134Serotonergic synapse_Homo sapiens_hsa047260.15653625
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15394800
136Basal cell carcinoma_Homo sapiens_hsa052170.13728371
137Colorectal cancer_Homo sapiens_hsa052100.12103672
138Calcium signaling pathway_Homo sapiens_hsa040200.11501069
139Dopaminergic synapse_Homo sapiens_hsa047280.10740016
140Notch signaling pathway_Homo sapiens_hsa043300.10338649
141Thyroid cancer_Homo sapiens_hsa052160.10145690
142Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.07959505

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