WDR35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)7.29953787
2cilium movement (GO:0003341)5.62068833
3axonemal dynein complex assembly (GO:0070286)5.34830189
4epithelial cilium movement (GO:0003351)5.16854085
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.75973182
6piRNA metabolic process (GO:0034587)4.34346853
7mitotic metaphase plate congression (GO:0007080)4.31432602
8metaphase plate congression (GO:0051310)4.25631413
9regulation of cilium movement (GO:0003352)4.19649763
10motile cilium assembly (GO:0044458)4.16535712
11mitotic sister chromatid cohesion (GO:0007064)4.11855236
12male meiosis (GO:0007140)4.01367355
13fusion of sperm to egg plasma membrane (GO:0007342)3.94254133
14protein localization to kinetochore (GO:0034501)3.90732440
15sperm motility (GO:0030317)3.83617305
16axoneme assembly (GO:0035082)3.83048487
17acrosome assembly (GO:0001675)3.81248606
18synaptonemal complex organization (GO:0070193)3.70354411
19ventricular system development (GO:0021591)3.66197654
20sperm-egg recognition (GO:0035036)3.59983377
21pore complex assembly (GO:0046931)3.54539456
22binding of sperm to zona pellucida (GO:0007339)3.50822182
23spermatid development (GO:0007286)3.50674572
24protein localization to cilium (GO:0061512)3.48374258
25chromatin remodeling at centromere (GO:0031055)3.40428149
26CENP-A containing nucleosome assembly (GO:0034080)3.39241176
27histone H2A acetylation (GO:0043968)3.38887788
28DNA ligation (GO:0006266)3.36278340
29synaptonemal complex assembly (GO:0007130)3.35628938
30establishment of chromosome localization (GO:0051303)3.35620791
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.34863722
32kinetochore organization (GO:0051383)3.33842672
33regulation of short-term neuronal synaptic plasticity (GO:0048172)3.28678282
34acrosome reaction (GO:0007340)3.28553584
35spindle checkpoint (GO:0031577)3.27474584
36DNA topological change (GO:0006265)3.21280543
37DNA unwinding involved in DNA replication (GO:0006268)3.19570855
38plasma membrane fusion (GO:0045026)3.19414838
39establishment of integrated proviral latency (GO:0075713)3.18563365
40* intraciliary transport (GO:0042073)3.17779454
41negative regulation of organelle assembly (GO:1902116)3.17638782
42sister chromatid segregation (GO:0000819)3.15811395
43negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.15224514
44negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.15224514
45negative regulation of mitotic sister chromatid segregation (GO:0033048)3.15224514
46negative regulation of mitotic sister chromatid separation (GO:2000816)3.15224514
47negative regulation of sister chromatid segregation (GO:0033046)3.15224514
48protein localization to chromosome, centromeric region (GO:0071459)3.14740144
49regulation of centriole replication (GO:0046599)3.14084000
50mitotic spindle checkpoint (GO:0071174)3.13495274
51regulation of microtubule-based movement (GO:0060632)3.13197075
52response to X-ray (GO:0010165)3.12361765
53negative regulation of chromosome segregation (GO:0051985)3.10309488
54DNA double-strand break processing (GO:0000729)3.10035847
55cell-cell recognition (GO:0009988)3.07413179
56histone exchange (GO:0043486)3.06737328
57positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.06677007
58regulation of mitotic metaphase/anaphase transition (GO:0030071)3.04696522
59regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.04696522
60regulation of centrosome duplication (GO:0010824)3.00660904
61regulation of mitotic sister chromatid segregation (GO:0033047)3.00276871
62regulation of sister chromatid segregation (GO:0033045)3.00276871
63regulation of mitotic sister chromatid separation (GO:0010965)3.00276871
64DNA replication-independent nucleosome organization (GO:0034724)2.96970636
65DNA replication-independent nucleosome assembly (GO:0006336)2.96970636
66mitotic sister chromatid segregation (GO:0000070)2.96213388
67vocalization behavior (GO:0071625)2.95982893
68regulation of centrosome cycle (GO:0046605)2.95510020
69mitotic spindle assembly checkpoint (GO:0007094)2.95422647
70pre-miRNA processing (GO:0031054)2.95082210
71intra-S DNA damage checkpoint (GO:0031573)2.94903843
72cell wall macromolecule metabolic process (GO:0044036)2.94532644
73cell wall macromolecule catabolic process (GO:0016998)2.94532644
74mitotic nuclear envelope disassembly (GO:0007077)2.94041414
75multicellular organism reproduction (GO:0032504)2.93869986
76spindle assembly checkpoint (GO:0071173)2.93513904
77microtubule severing (GO:0051013)2.91419598
78regulation of chromosome segregation (GO:0051983)2.90886368
79non-recombinational repair (GO:0000726)2.87428065
80double-strand break repair via nonhomologous end joining (GO:0006303)2.87428065
81mitotic chromosome condensation (GO:0007076)2.85644471
82protein localization to synapse (GO:0035418)2.84363294
83lactate metabolic process (GO:0006089)2.83566791
84* microtubule-based movement (GO:0007018)2.83524424
85synaptic vesicle exocytosis (GO:0016079)2.83242911
86DNA methylation involved in gamete generation (GO:0043046)2.82974765
87mitotic G2/M transition checkpoint (GO:0044818)2.80521727
88regulation of spindle organization (GO:0090224)2.79792839
89glutamate secretion (GO:0014047)2.79547820
90DNA replication-dependent nucleosome organization (GO:0034723)2.79016189
91DNA replication-dependent nucleosome assembly (GO:0006335)2.79016189
92regulation of mitotic spindle organization (GO:0060236)2.78641106
93replication fork processing (GO:0031297)2.78402954
94kinetochore assembly (GO:0051382)2.76404019
95calcium ion-dependent exocytosis (GO:0017156)2.76271553
96microtubule depolymerization (GO:0007019)2.74763853
97synaptic vesicle docking involved in exocytosis (GO:0016081)2.73225863
98ribosome assembly (GO:0042255)2.73173672
99protein polyglutamylation (GO:0018095)2.73160850
100layer formation in cerebral cortex (GO:0021819)2.72234944
101negative regulation of inclusion body assembly (GO:0090084)2.71740329
102membrane disassembly (GO:0030397)2.71631497
103nuclear envelope disassembly (GO:0051081)2.71631497
104IMP biosynthetic process (GO:0006188)2.69979583
105regulation of meiosis I (GO:0060631)2.68902608
106negative regulation of DNA recombination (GO:0045910)2.68357028
107* cilium organization (GO:0044782)2.68275516
108negative regulation of DNA repair (GO:0045738)2.67385051
109left/right pattern formation (GO:0060972)2.66979229
110microtubule bundle formation (GO:0001578)2.66487568
111somatic diversification of immune receptors via somatic mutation (GO:0002566)2.66075201
112somatic hypermutation of immunoglobulin genes (GO:0016446)2.66075201
113regulation of DNA endoreduplication (GO:0032875)2.65401746
114IMP metabolic process (GO:0046040)2.65172868
115regulation of helicase activity (GO:0051095)2.64925794
116synaptic vesicle maturation (GO:0016188)2.62644411
117notochord development (GO:0030903)2.62412616
118ATP-dependent chromatin remodeling (GO:0043044)2.62308283
119neuron cell-cell adhesion (GO:0007158)2.61645575
120* cilium assembly (GO:0042384)2.60002036
121regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.57488700
122regulation of mitotic spindle checkpoint (GO:1903504)2.57362130
123regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.57362130
124positive regulation of synapse maturation (GO:0090129)2.56724089
125purine nucleobase biosynthetic process (GO:0009113)2.55340645
126regulation of inclusion body assembly (GO:0090083)2.55120423
127microtubule polymerization or depolymerization (GO:0031109)2.54962997
128nuclear pore organization (GO:0006999)2.53181420
129centriole replication (GO:0007099)2.52981538
130cilium morphogenesis (GO:0060271)2.52884925
131hyperosmotic salinity response (GO:0042538)2.52072971
132nuclear pore complex assembly (GO:0051292)2.51892549
133DNA duplex unwinding (GO:0032508)2.50255181
134innervation (GO:0060384)2.50050232
135DNA strand elongation involved in DNA replication (GO:0006271)2.48880639
136DNA geometric change (GO:0032392)2.48755537
137meiotic chromosome segregation (GO:0045132)2.48561437
138chaperone-mediated protein complex assembly (GO:0051131)2.47786107
139regulation of glutamate receptor signaling pathway (GO:1900449)2.47313443
140positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.47016553
141regulation of synaptic vesicle exocytosis (GO:2000300)2.45827082
142male meiosis I (GO:0007141)2.44948423
143axonal fasciculation (GO:0007413)2.44931988
144negative regulation of mitosis (GO:0045839)2.44685186
145regulation of protein polyubiquitination (GO:1902914)2.44460972
146meiotic nuclear division (GO:0007126)2.41686043
147neuron recognition (GO:0008038)2.41279005
148positive regulation of chromosome segregation (GO:0051984)2.39287922
149DNA strand elongation (GO:0022616)2.38850770
150maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.37516675
151germ cell development (GO:0007281)2.37384858
152regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.37352537
153nucleobase biosynthetic process (GO:0046112)2.35761430
154regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.35199585
155mitotic G2 DNA damage checkpoint (GO:0007095)2.34941751
156anterior/posterior axis specification, embryo (GO:0008595)2.34332033
157DNA replication initiation (GO:0006270)2.34329288
158cell recognition (GO:0008037)2.34181611
159synaptic transmission, glutamatergic (GO:0035249)2.31279564
160nucleoside diphosphate phosphorylation (GO:0006165)2.30606268
161* cellular component assembly involved in morphogenesis (GO:0010927)2.29795859
162proline transport (GO:0015824)2.29106808
163apical protein localization (GO:0045176)2.28265175
164nonmotile primary cilium assembly (GO:0035058)2.27574296
165locomotory exploration behavior (GO:0035641)2.26669624
166gene silencing by RNA (GO:0031047)2.26237100
167chromosome organization involved in meiosis (GO:0070192)2.26118085
168neuron-neuron synaptic transmission (GO:0007270)2.25285704
169single fertilization (GO:0007338)2.25076848
170neurotransmitter secretion (GO:0007269)2.25074540
171spermatogenesis (GO:0007283)2.24799000
172male gamete generation (GO:0048232)2.23752497
173reproduction (GO:0000003)2.22812895
174synaptic vesicle endocytosis (GO:0048488)2.22710348
175establishment of monopolar cell polarity (GO:0061162)2.22623366
176establishment or maintenance of monopolar cell polarity (GO:0061339)2.22623366
177establishment of apical/basal cell polarity (GO:0035089)2.21518901
178embryonic body morphogenesis (GO:0010172)2.21463077
179paraxial mesoderm development (GO:0048339)2.21301968
180striatum development (GO:0021756)2.21213081
181membrane depolarization during action potential (GO:0086010)2.16894601
182cellular process involved in reproduction in multicellular organism (GO:0022412)2.16517314
183fertilization (GO:0009566)2.15934352
184regulation of protein kinase A signaling (GO:0010738)2.15504067

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.25497927
2EZH2_22144423_ChIP-Seq_EOC_Human5.12779056
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.73923271
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.68299474
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.34006324
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.80961424
7GBX2_23144817_ChIP-Seq_PC3_Human2.65172104
8AR_21909140_ChIP-Seq_LNCAP_Human2.57004825
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.50453980
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.50394688
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.40274184
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39371312
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.32522921
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18804725
15ELK1_19687146_ChIP-ChIP_HELA_Human2.14203530
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03356051
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96636950
18REST_21632747_ChIP-Seq_MESCs_Mouse1.94922701
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86470202
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.85533340
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85497412
22PADI4_21655091_ChIP-ChIP_MCF-7_Human1.77365313
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.76556184
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.76165880
25FUS_26573619_Chip-Seq_HEK293_Human1.75666229
26YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72064294
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68832928
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.67662323
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.66299120
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57616408
31SMAD4_21799915_ChIP-Seq_A2780_Human1.55206820
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.52907869
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52184558
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.49298456
35SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.47286446
36ZNF274_21170338_ChIP-Seq_K562_Hela1.47132955
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.46715069
38TAF15_26573619_Chip-Seq_HEK293_Human1.46478731
39RNF2_27304074_Chip-Seq_NSC_Mouse1.45427853
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.45383971
41PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.44226327
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.42400605
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.41409960
44VDR_22108803_ChIP-Seq_LS180_Human1.41050416
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.40211453
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39916153
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38245430
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37648326
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35596625
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35449182
51NANOG_16153702_ChIP-ChIP_HESCs_Human1.34450537
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.33348547
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33131094
54NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.32795174
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.31911588
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28969019
57RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28635444
58SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.28498330
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28434313
60DROSHA_22980978_ChIP-Seq_HELA_Human1.27747138
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26715431
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.25913660
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24953682
64P300_19829295_ChIP-Seq_ESCs_Human1.24674253
65* STAT3_23295773_ChIP-Seq_U87_Human1.22648208
66IGF1R_20145208_ChIP-Seq_DFB_Human1.22593655
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22447584
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21737505
69EED_16625203_ChIP-ChIP_MESCs_Mouse1.20309237
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20135962
71GATA1_26923725_Chip-Seq_HPCs_Mouse1.19760302
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.19657792
73TCF4_23295773_ChIP-Seq_U87_Human1.19376605
74SOX2_16153702_ChIP-ChIP_HESCs_Human1.17306325
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.17279639
76EZH2_18974828_ChIP-Seq_MESCs_Mouse1.17279639
77SOX9_26525672_Chip-Seq_HEART_Mouse1.17235565
78FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17020492
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16841996
80KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16786144
81JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16492569
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16318467
83SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15699238
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.15414907
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.15238480
86BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14997763
87SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.14943733
88ELK4_26923725_Chip-Seq_MESODERM_Mouse1.14440621
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14324174
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13977793
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13904993
92ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13615509
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13533921
94SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13163148
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12840164
96SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12549596
97ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11935572
98MYC_18940864_ChIP-ChIP_HL60_Human1.11845824
99SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10619042
100SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10608447
101SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.10173466
102RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09388361
103JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08594127
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08509132
105SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07823930
106* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07797699
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.07149120
108STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06358625
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06137133
110EZH2_27294783_Chip-Seq_ESCs_Mouse1.05985979
111NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05816268
112PIAS1_25552417_ChIP-Seq_VCAP_Human1.05143461
113YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04919329
114SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04411868
115BCAT_22108803_ChIP-Seq_LS180_Human1.03969708
116NFE2_27457419_Chip-Seq_LIVER_Mouse1.03140429
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03097510
118FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01813501
119SOX2_21211035_ChIP-Seq_LN229_Gbm1.01757111
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00971339
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00537705
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99844305
123POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.99645964
124MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99266867
125MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99048535
126AHR_22903824_ChIP-Seq_MCF-7_Human0.98959807
127SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98795828
128CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98750445
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98646754
130ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98315515
131PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98061942
132POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97830940
133NANOG_18555785_Chip-Seq_ESCs_Mouse0.97648854
134TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97213160
135PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96783850
136TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96723280
137SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96157398
138ER_23166858_ChIP-Seq_MCF-7_Human0.95959819
139TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95763329
140E2F1_18555785_Chip-Seq_ESCs_Mouse0.94824569
141AR_19668381_ChIP-Seq_PC3_Human0.93430920
142EWS_26573619_Chip-Seq_HEK293_Human0.93364362
143SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92842553
144VDR_23849224_ChIP-Seq_CD4+_Human0.92717625
145KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90836282
146KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90836282
147KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90836282
148CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90552519
149TCF4_18268006_ChIP-ChIP_LS174T_Human0.90509726
150SOX17_20123909_ChIP-Seq_XEN_Mouse0.90283083
151DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88619058
152P300_18555785_Chip-Seq_ESCs_Mouse0.86104382
153KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85901543
154TTF2_22483619_ChIP-Seq_HELA_Human0.85800019

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization3.37718369
2MP0004859_abnormal_synaptic_plasticity3.15425016
3MP0008057_abnormal_DNA_replication3.07571386
4MP0003880_abnormal_central_pattern2.77352184
5MP0008877_abnormal_DNA_methylation2.72205626
6MP0008058_abnormal_DNA_repair2.68125030
7MP0005623_abnormal_meninges_morphology2.66393998
8MP0002653_abnormal_ependyma_morphology2.57566203
9MP0004957_abnormal_blastocyst_morpholog2.30881972
10MP0003941_abnormal_skin_development2.30419051
11MP0003111_abnormal_nucleus_morphology2.30293529
12MP0004270_analgesia2.18139867
13MP0003077_abnormal_cell_cycle2.15493426
14MP0003635_abnormal_synaptic_transmissio2.13342287
15MP0009780_abnormal_chondrocyte_physiolo2.12147727
16MP0003693_abnormal_embryo_hatching2.06002833
17MP0010352_gastrointestinal_tract_polyps2.02904380
18MP0009697_abnormal_copulation1.99436045
19MP0008932_abnormal_embryonic_tissue1.99003571
20MP0009046_muscle_twitch1.97794582
21MP0003698_abnormal_male_reproductive1.88706064
22MP0002938_white_spotting1.82111909
23MP0001984_abnormal_olfaction1.81313211
24MP0008007_abnormal_cellular_replicative1.80464511
25MP0002063_abnormal_learning/memory/cond1.79141350
26MP0003787_abnormal_imprinting1.77095593
27MP0004133_heterotaxia1.74755702
28MP0000566_synostosis1.69491685
29MP0009745_abnormal_behavioral_response1.68647199
30MP0006072_abnormal_retinal_apoptosis1.66068480
31MP0000778_abnormal_nervous_system1.65483778
32MP0003122_maternal_imprinting1.60735693
33MP0004885_abnormal_endolymph1.60284822
34MP0002572_abnormal_emotion/affect_behav1.59126522
35MP0004233_abnormal_muscle_weight1.58316662
36MP0002064_seizures1.57038646
37MP0001929_abnormal_gametogenesis1.56253519
38MP0002697_abnormal_eye_size1.55867483
39MP0003283_abnormal_digestive_organ1.55091292
40MP0005248_abnormal_Harderian_gland1.53486869
41MP0005394_taste/olfaction_phenotype1.51624599
42MP0005499_abnormal_olfactory_system1.51624599
43MP0002734_abnormal_mechanical_nocicepti1.51274775
44MP0009703_decreased_birth_body1.44336784
45MP0001968_abnormal_touch/_nociception1.43626912
46MP0005646_abnormal_pituitary_gland1.42354949
47MP0001486_abnormal_startle_reflex1.41686532
48MP0002160_abnormal_reproductive_system1.38728157
49MP0002085_abnormal_embryonic_tissue1.38178732
50MP0009672_abnormal_birth_weight1.37841454
51MP0003121_genomic_imprinting1.35111814
52MP0001286_abnormal_eye_development1.34465507
53MP0010307_abnormal_tumor_latency1.34320657
54MP0002272_abnormal_nervous_system1.33549318
55MP0004197_abnormal_fetal_growth/weight/1.29833762
56MP0001672_abnormal_embryogenesis/_devel1.28123731
57MP0005380_embryogenesis_phenotype1.28123731
58MP0001730_embryonic_growth_arrest1.28107335
59MP0003718_maternal_effect1.27215053
60MP0002210_abnormal_sex_determination1.26776426
61MP0001440_abnormal_grooming_behavior1.25297247
62MP0010030_abnormal_orbit_morphology1.24859358
63MP0003123_paternal_imprinting1.23924911
64MP0005551_abnormal_eye_electrophysiolog1.22600457
65MP0005171_absent_coat_pigmentation1.20416130
66MP0002751_abnormal_autonomic_nervous1.19827908
67MP0002736_abnormal_nociception_after1.19818714
68MP0003861_abnormal_nervous_system1.18048984
69MP0000537_abnormal_urethra_morphology1.17872817
70MP0000350_abnormal_cell_proliferation1.17296461
71MP0008789_abnormal_olfactory_epithelium1.17162962
72MP0001697_abnormal_embryo_size1.17149654
73MP0002184_abnormal_innervation1.15490875
74MP0003984_embryonic_growth_retardation1.14852102
75MP0002152_abnormal_brain_morphology1.14634446
76MP0005253_abnormal_eye_physiology1.13377154
77MP0000955_abnormal_spinal_cord1.12714174
78MP0002088_abnormal_embryonic_growth/wei1.12547502
79MP0001346_abnormal_lacrimal_gland1.11980435
80MP0002111_abnormal_tail_morphology1.11687861
81MP0002092_abnormal_eye_morphology1.11482145
82MP0002557_abnormal_social/conspecific_i1.10383795
83MP0001145_abnormal_male_reproductive1.10234154
84MP0000383_abnormal_hair_follicle1.09552878
85MP0002882_abnormal_neuron_morphology1.09380702
86MP0005503_abnormal_tendon_morphology1.08914727
87MP0003942_abnormal_urinary_system1.08475020
88MP0004811_abnormal_neuron_physiology1.08222536
89MP0003935_abnormal_craniofacial_develop1.07591348
90MP0002233_abnormal_nose_morphology1.07472894
91MP0000631_abnormal_neuroendocrine_gland1.06967618
92MP0010678_abnormal_skin_adnexa1.06767739
93MP0002102_abnormal_ear_morphology1.06734887
94MP0001293_anophthalmia1.05184548
95MP0002067_abnormal_sensory_capabilities1.04909568
96MP0003943_abnormal_hepatobiliary_system1.04000706
97MP0002161_abnormal_fertility/fecundity1.03557236
98MP0000432_abnormal_head_morphology1.03502762
99MP0004858_abnormal_nervous_system1.03418473
100MP0003890_abnormal_embryonic-extraembry1.03082939
101MP0001529_abnormal_vocalization1.02330946
102MP0000534_abnormal_ureter_morphology1.02001160
103MP0000751_myopathy0.99560409
104MP0003567_abnormal_fetal_cardiomyocyte0.98012133
105MP0006292_abnormal_olfactory_placode0.97393221
106MP0000049_abnormal_middle_ear0.96590431
107MP0003755_abnormal_palate_morphology0.96522311
108MP0002080_prenatal_lethality0.96287726
109MP0003937_abnormal_limbs/digits/tail_de0.95659382
110MP0000653_abnormal_sex_gland0.95395298
111MP0003115_abnormal_respiratory_system0.94547479
112MP0000428_abnormal_craniofacial_morphol0.93364300
113MP0000762_abnormal_tongue_morphology0.93338103
114MP0001485_abnormal_pinna_reflex0.92912465
115MP0002282_abnormal_trachea_morphology0.92070948
116MP0000569_abnormal_digit_pigmentation0.91443125
117MP0005423_abnormal_somatic_nervous0.89141211
118MP0000013_abnormal_adipose_tissue0.88769137
119MP0002735_abnormal_chemical_nociception0.88043984
120MP0002084_abnormal_developmental_patter0.87471633
121MP0003119_abnormal_digestive_system0.86432773
122MP0005220_abnormal_exocrine_pancreas0.85221525
123MP0000579_abnormal_nail_morphology0.85009543
124MP0002752_abnormal_somatic_nervous0.84477537
125MP0005187_abnormal_penis_morphology0.84443996
126MP0001299_abnormal_eye_distance/0.84265068
127MP0001849_ear_inflammation0.84067276
128MP0000647_abnormal_sebaceous_gland0.84028875
129MP0005389_reproductive_system_phenotype0.83771439
130MP0004272_abnormal_basement_membrane0.83530581
131MP0005408_hypopigmentation0.82715350
132MP0003385_abnormal_body_wall0.82675583
133MP0002108_abnormal_muscle_morphology0.82637477
134MP0002837_dystrophic_cardiac_calcinosis0.82282672
135MP0002009_preneoplasia0.81969792
136MP0005377_hearing/vestibular/ear_phenot0.81554251
137MP0003878_abnormal_ear_physiology0.81554251
138MP0001970_abnormal_pain_threshold0.81414562
139MP0002733_abnormal_thermal_nociception0.80373661
140MP0002116_abnormal_craniofacial_bone0.80183959
141MP0001324_abnormal_eye_pigmentation0.80106304
142MP0005391_vision/eye_phenotype0.79680952
143MP0001501_abnormal_sleep_pattern0.79324469
144MP0005386_behavior/neurological_phenoty0.78372185
145MP0004924_abnormal_behavior0.78372185
146MP0003136_yellow_coat_color0.78081936
147MP0000516_abnormal_urinary_system0.77812416
148MP0005367_renal/urinary_system_phenotyp0.77812416
149MP0002234_abnormal_pharynx_morphology0.77753142
150MP0005395_other_phenotype0.77669882
151MP0001963_abnormal_hearing_physiology0.77385973
152MP0002066_abnormal_motor_capabilities/c0.77217044
153MP0002086_abnormal_extraembryonic_tissu0.77159435
154MP0010094_abnormal_chromosome_stability0.76335100
155MP0003634_abnormal_glial_cell0.76183104
156MP0004145_abnormal_muscle_electrophysio0.75759293
157MP0001177_atelectasis0.73873378
158MP0009250_abnormal_appendicular_skeleto0.73121103

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.91831724
2Absent/shortened dynein arms (HP:0200106)6.01403371
3Dynein arm defect of respiratory motile cilia (HP:0012255)6.01403371
4Abnormal respiratory motile cilium physiology (HP:0012261)5.93476646
5Abnormal ciliary motility (HP:0012262)5.46691955
6Abnormal respiratory motile cilium morphology (HP:0005938)5.10913955
7Abnormal respiratory epithelium morphology (HP:0012253)5.10913955
8Rhinitis (HP:0012384)4.82748594
9Chronic bronchitis (HP:0004469)3.49229501
10Abnormality of the lower motor neuron (HP:0002366)3.46667756
11Nephronophthisis (HP:0000090)3.03917687
12Focal motor seizures (HP:0011153)2.97976144
13Hepatoblastoma (HP:0002884)2.96575540
14Medial flaring of the eyebrow (HP:0010747)2.95935173
15Gait imbalance (HP:0002141)2.92702848
16Papillary thyroid carcinoma (HP:0002895)2.86039282
17Volvulus (HP:0002580)2.85312080
18Hypoglycemic seizures (HP:0002173)2.84914635
19Colon cancer (HP:0003003)2.81961211
20Supernumerary spleens (HP:0009799)2.80753581
21Congenital primary aphakia (HP:0007707)2.78497207
22Abnormal lung lobation (HP:0002101)2.63254738
23Intestinal atresia (HP:0011100)2.59102825
24Pancreatic cysts (HP:0001737)2.52371159
25Rhabdomyosarcoma (HP:0002859)2.51115614
26Infertility (HP:0000789)2.51063216
27Nephrogenic diabetes insipidus (HP:0009806)2.47090012
28Medulloblastoma (HP:0002885)2.46171652
29Epileptic encephalopathy (HP:0200134)2.42268366
30Abnormality of midbrain morphology (HP:0002418)2.42005201
31Molar tooth sign on MRI (HP:0002419)2.42005201
32Abnormality of the labia minora (HP:0012880)2.41679057
33Genital tract atresia (HP:0001827)2.33967941
34Focal seizures (HP:0007359)2.30677108
35Vaginal atresia (HP:0000148)2.29502087
36Increased nuchal translucency (HP:0010880)2.25528265
37Chromsome breakage (HP:0040012)2.25191838
38Amyotrophic lateral sclerosis (HP:0007354)2.24282775
39Abnormality of the renal medulla (HP:0100957)2.23002171
40Abnormality of chromosome stability (HP:0003220)2.18349395
41Poor coordination (HP:0002370)2.17457607
42Neoplasm of the oral cavity (HP:0100649)2.17257478
43Abnormality of the astrocytes (HP:0100707)2.16600421
44Astrocytoma (HP:0009592)2.16600421
45Visual hallucinations (HP:0002367)2.15566434
46Chromosomal breakage induced by crosslinking agents (HP:0003221)2.10756739
47Pancreatic fibrosis (HP:0100732)2.07403485
48Hyperinsulinemic hypoglycemia (HP:0000825)2.05627051
49Tubulointerstitial nephritis (HP:0001970)2.04709136
50Myokymia (HP:0002411)2.03543232
51Thyroid carcinoma (HP:0002890)2.00982907
52Cortical dysplasia (HP:0002539)2.00957115
53* Preaxial hand polydactyly (HP:0001177)1.99949860
54Sloping forehead (HP:0000340)1.97147350
55* Postaxial hand polydactyly (HP:0001162)1.97010942
56Bronchiectasis (HP:0002110)1.97005791
57Atonic seizures (HP:0010819)1.94913660
58Ependymoma (HP:0002888)1.94487670
59Progressive cerebellar ataxia (HP:0002073)1.93966487
60Meckel diverticulum (HP:0002245)1.91065232
61Cutaneous finger syndactyly (HP:0010554)1.89007171
62Gastrointestinal atresia (HP:0002589)1.87419064
63Aplasia/Hypoplasia of the lens (HP:0008063)1.86452551
64Hypoglycemic coma (HP:0001325)1.85746421
65Anencephaly (HP:0002323)1.82634842
66Neoplasm of striated muscle (HP:0009728)1.82294397
67Sclerocornea (HP:0000647)1.81878183
68* Median cleft lip (HP:0000161)1.79710650
69* Facial cleft (HP:0002006)1.79698116
70Abnormality of the ileum (HP:0001549)1.79624025
71Specific learning disability (HP:0001328)1.77921971
72Shoulder girdle muscle weakness (HP:0003547)1.77194404
73Abdominal situs inversus (HP:0003363)1.77124054
74Abnormality of abdominal situs (HP:0011620)1.77124054
75Postaxial foot polydactyly (HP:0001830)1.76788588
76Anophthalmia (HP:0000528)1.76712576
77Overlapping toe (HP:0001845)1.76432950
78Abnormality of the duodenum (HP:0002246)1.75847232
79Impaired vibration sensation in the lower limbs (HP:0002166)1.73788357
80Esophageal atresia (HP:0002032)1.73256690
81Absence seizures (HP:0002121)1.73084965
82Aplasia/Hypoplasia of the uvula (HP:0010293)1.72413295
83Decreased lacrimation (HP:0000633)1.71190621
84Megalencephaly (HP:0001355)1.71085088
85Occipital encephalocele (HP:0002085)1.70742412
86Fibular hypoplasia (HP:0003038)1.70712135
87Renal hypoplasia (HP:0000089)1.68553996
88True hermaphroditism (HP:0010459)1.66970600
89Cutaneous syndactyly (HP:0012725)1.66705245
90Symptomatic seizures (HP:0011145)1.66645000
91Glioma (HP:0009733)1.66538924
92Aqueductal stenosis (HP:0002410)1.66516697
93Hemiparesis (HP:0001269)1.65204105
94Microglossia (HP:0000171)1.65161231
95Aplasia/Hypoplasia of the tongue (HP:0010295)1.64649447
96Small intestinal stenosis (HP:0012848)1.64576960
97Duodenal stenosis (HP:0100867)1.64576960
98Absent radius (HP:0003974)1.64415259
99Aplasia involving bones of the upper limbs (HP:0009823)1.64326317
100Aplasia of the phalanges of the hand (HP:0009802)1.64326317
101Aplasia involving bones of the extremities (HP:0009825)1.64326317
102Dandy-Walker malformation (HP:0001305)1.63888014
103Biliary tract neoplasm (HP:0100574)1.63681203
104* Abnormality of dentin (HP:0010299)1.63611396
105Bell-shaped thorax (HP:0001591)1.62932706
106Dialeptic seizures (HP:0011146)1.62257045
107Bifid tongue (HP:0010297)1.61459206
108Cystic liver disease (HP:0006706)1.61388787
109Aplasia/Hypoplasia of the fibula (HP:0006492)1.61237537
110Abnormality of methionine metabolism (HP:0010901)1.60617098
111Malignant gastrointestinal tract tumors (HP:0006749)1.56383366
112Gastrointestinal carcinoma (HP:0002672)1.56383366
113Missing ribs (HP:0000921)1.56227703
114Narrow forehead (HP:0000341)1.54629656
115Aplasia involving forearm bones (HP:0009822)1.54442970
116Absent forearm bone (HP:0003953)1.54442970
117* Short ribs (HP:0000773)1.53999843
118Abnormal biliary tract morphology (HP:0012440)1.52127024
119Central scotoma (HP:0000603)1.51384499
120Dental crowding (HP:0000678)1.50915588
121Febrile seizures (HP:0002373)1.50699638
122Amblyopia (HP:0000646)1.50317576
123Neoplasm of the colon (HP:0100273)1.50148290
124Myelomeningocele (HP:0002475)1.50093217
125Nephroblastoma (Wilms tumor) (HP:0002667)1.49684493
126Abnormality of ocular smooth pursuit (HP:0000617)1.48823889
127Midline defect of the nose (HP:0004122)1.48703234
128Neoplasm of the small intestine (HP:0100833)1.48014037
129Hypoplastic pelvis (HP:0008839)1.47148746
130Holoprosencephaly (HP:0001360)1.46086882
131Neoplasm of the liver (HP:0002896)1.45325280
132Hyperventilation (HP:0002883)1.44771918
133Embryonal renal neoplasm (HP:0011794)1.44566289
134Oculomotor apraxia (HP:0000657)1.43865145
135Short humerus (HP:0005792)1.42454596
136Stage 5 chronic kidney disease (HP:0003774)1.42358553
137Chronic hepatic failure (HP:0100626)1.42244054
138Broad foot (HP:0001769)1.41480039
139Hypodontia (HP:0000668)1.41395111
140Generalized tonic-clonic seizures (HP:0002069)1.41274519
141Short foot (HP:0001773)1.40942057
142Impaired smooth pursuit (HP:0007772)1.39798850
143Scotoma (HP:0000575)1.38961288
144Tubular atrophy (HP:0000092)1.38912411
145Gaze-evoked nystagmus (HP:0000640)1.38188933
146Tubulointerstitial abnormality (HP:0001969)1.37942533
147Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.36891155
148Absent eyebrow (HP:0002223)1.34632523
149* Omphalocele (HP:0001539)1.32351852
150Abnormality of the anterior horn cell (HP:0006802)1.31115915
151Degeneration of anterior horn cells (HP:0002398)1.31115915
152Drooling (HP:0002307)1.30577008
153Excessive salivation (HP:0003781)1.30577008
154* Congenital hepatic fibrosis (HP:0002612)1.29910958
155Hypopigmentation of the fundus (HP:0007894)1.29404720
156Aplasia/Hypoplasia of the sternum (HP:0006714)1.28674256
157Dysdiadochokinesis (HP:0002075)1.27886839

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.24538445
2PDK44.24538445
3PNCK3.57198707
4TNIK3.32287918
5BRSK22.96927496
6EPHA42.84309028
7BUB12.78483865
8MKNK12.73955333
9PDK22.64747120
10SRPK12.54722935
11NTRK32.51276164
12PBK2.41299463
13PRKD32.20098093
14EIF2AK32.19349088
15MAP3K42.02555133
16PLK42.00140548
17CASK1.94950206
18PLK21.88018813
19EIF2AK11.74329165
20PAK61.72641184
21MAP2K71.60200004
22MST41.58505556
23MARK11.57424500
24TESK11.57273901
25TAF11.56791610
26PTK2B1.55128237
27MAP3K91.54310646
28CDC71.49614609
29CCNB11.48601358
30AKT31.48052365
31FRK1.46108975
32MINK11.43450659
33MAP4K21.38593948
34DDR21.38096157
35FGFR21.37937310
36CDK121.37557345
37NTRK21.33266245
38TRIM281.32761319
39NEK11.32171207
40ERBB31.28613905
41LATS21.26288586
42PAK31.23723547
43VRK11.22504655
44STK31.21092564
45BMPR1B1.20225022
46KSR11.18433106
47PLK31.18323506
48PRPF4B1.16269847
49ERBB41.15692375
50WEE11.13392648
51TSSK61.13389755
52MAP3K21.09439554
53DAPK21.03072913
54CAMK1G1.02734307
55NEK21.01085652
56FER1.00971688
57WNK31.00954569
58PRKCG0.99816448
59CSNK1G10.99111564
60TTK0.96713477
61EPHA20.95727673
62KSR20.93680878
63DAPK10.91682989
64STK380.90940607
65EIF2AK20.88132195
66LMTK20.87438309
67AURKB0.86997535
68NUAK10.86784173
69ICK0.86296269
70WNK10.85883448
71LATS10.85696587
72WNK40.84608426
73FLT30.83905311
74BCR0.79521326
75NTRK10.79209259
76CDK180.79118747
77CDK150.76413886
78CDK140.75765708
79BMPR20.74527423
80STK38L0.72871209
81CDK50.71522228
82UHMK10.70861153
83MAP2K40.70543844
84STK390.69963627
85GRK50.69544782
86ZAK0.69533958
87CDC42BPA0.68810557
88PLK10.67976564
89CSNK1G20.67231052
90FGFR10.67071207
91NME10.65660970
92CHEK20.64933448
93CSNK1A1L0.64692402
94NEK90.63145913
95PASK0.63144202
96CDK11A0.62719471
97PHKG10.62214054
98PHKG20.62214054
99MAPK150.61284638
100CAMK2A0.61229267
101SGK4940.59963621
102SGK2230.59963621
103CAMK2B0.59681536
104TYRO30.58776843
105MAP3K100.57466130
106SGK20.56951654
107YES10.56847855
108CSNK1G30.56297174
109BRSK10.56153313
110VRK20.53682637
111BRD40.53150612
112CDK70.53066265
113CAMKK10.52224082
114CHEK10.51005029
115MAPK100.50840212
116DYRK30.48039571
117PRKCI0.47846621
118OXSR10.47566487
119ALK0.47520767
120CDK20.47520049
121NLK0.46838596
122CSNK1E0.46507653
123CAMK1D0.46342700
124PDGFRA0.46221415
125CDK30.46163670
126AURKA0.45753645
127ATM0.45502195
128ADRBK10.43714055
129BRAF0.43630114
130STK40.42993064
131MAPK130.42932194
132PRKDC0.41315707
133CDK60.40706391
134MET0.40319386
135RPS6KA40.39992476
136SIK20.39726002
137DYRK1A0.39547528
138CSNK1D0.39179457
139CDK10.37451801
140ATR0.36856448
141GSK3B0.36104467
142MKNK20.35628485
143MST1R0.35352328
144NEK60.34978665
145SGK10.34111182
146MELK0.32867366
147STK240.31606466
148CDK90.31478100
149PKN20.28542794
150ERBB20.28194496
151SCYL20.27078642
152CSNK2A20.26591040
153STK100.26389433
154STK160.25193029
155CDK80.24426840

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.20555364
2Mismatch repair_Homo sapiens_hsa034303.00917064
3Nicotine addiction_Homo sapiens_hsa050332.82471171
4Synaptic vesicle cycle_Homo sapiens_hsa047212.76524486
5DNA replication_Homo sapiens_hsa030302.57754521
6Propanoate metabolism_Homo sapiens_hsa006402.55291712
7Amphetamine addiction_Homo sapiens_hsa050312.43770960
8Long-term potentiation_Homo sapiens_hsa047202.35528111
9Olfactory transduction_Homo sapiens_hsa047402.27709074
10Spliceosome_Homo sapiens_hsa030402.25392231
11Homologous recombination_Homo sapiens_hsa034402.22989809
12Circadian entrainment_Homo sapiens_hsa047132.09385702
13Protein export_Homo sapiens_hsa030602.09232619
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07727598
15Nucleotide excision repair_Homo sapiens_hsa034202.05121531
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.04580431
17Insulin secretion_Homo sapiens_hsa049111.96942659
18Proteasome_Homo sapiens_hsa030501.92318926
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.89142212
20Base excision repair_Homo sapiens_hsa034101.87838068
21GABAergic synapse_Homo sapiens_hsa047271.86803424
22Steroid biosynthesis_Homo sapiens_hsa001001.84639766
23Oocyte meiosis_Homo sapiens_hsa041141.84270936
24Dopaminergic synapse_Homo sapiens_hsa047281.83082415
25One carbon pool by folate_Homo sapiens_hsa006701.83035506
26Phototransduction_Homo sapiens_hsa047441.81955329
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78210250
28Vitamin B6 metabolism_Homo sapiens_hsa007501.78183271
29Glutamatergic synapse_Homo sapiens_hsa047241.71510709
30RNA degradation_Homo sapiens_hsa030181.70606840
31Morphine addiction_Homo sapiens_hsa050321.66773441
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64455722
33Taste transduction_Homo sapiens_hsa047421.61981257
34Collecting duct acid secretion_Homo sapiens_hsa049661.60287736
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57241168
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.53276278
37Renin secretion_Homo sapiens_hsa049241.52771367
38RNA polymerase_Homo sapiens_hsa030201.49412418
39Selenocompound metabolism_Homo sapiens_hsa004501.49064505
40Salivary secretion_Homo sapiens_hsa049701.47148745
41Hedgehog signaling pathway_Homo sapiens_hsa043401.44189875
42Lysine degradation_Homo sapiens_hsa003101.42253839
43Gastric acid secretion_Homo sapiens_hsa049711.41819575
44Estrogen signaling pathway_Homo sapiens_hsa049151.41713554
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35813313
46Cocaine addiction_Homo sapiens_hsa050301.34847106
47Glucagon signaling pathway_Homo sapiens_hsa049221.32443220
48Gap junction_Homo sapiens_hsa045401.27429257
49Calcium signaling pathway_Homo sapiens_hsa040201.26827423
50Serotonergic synapse_Homo sapiens_hsa047261.26191300
51Melanogenesis_Homo sapiens_hsa049161.25127038
52Vibrio cholerae infection_Homo sapiens_hsa051101.25125847
53Fatty acid metabolism_Homo sapiens_hsa012121.22992875
54Cholinergic synapse_Homo sapiens_hsa047251.22334716
55Oxytocin signaling pathway_Homo sapiens_hsa049211.21857434
56Long-term depression_Homo sapiens_hsa047301.18014345
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16673357
58Basal cell carcinoma_Homo sapiens_hsa052171.15759230
59Hippo signaling pathway_Homo sapiens_hsa043901.15751885
60Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15735972
61Alcoholism_Homo sapiens_hsa050341.13862925
62mRNA surveillance pathway_Homo sapiens_hsa030151.12877800
63Axon guidance_Homo sapiens_hsa043601.11333962
64Huntingtons disease_Homo sapiens_hsa050161.11275719
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11017570
66Cardiac muscle contraction_Homo sapiens_hsa042601.09537334
67Wnt signaling pathway_Homo sapiens_hsa043101.08910104
68Butanoate metabolism_Homo sapiens_hsa006501.08015846
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05761470
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03159711
71p53 signaling pathway_Homo sapiens_hsa041151.01724910
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00903143
73cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00608644
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00071547
75GnRH signaling pathway_Homo sapiens_hsa049120.99334495
76Purine metabolism_Homo sapiens_hsa002300.97920331
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97491177
78Dorso-ventral axis formation_Homo sapiens_hsa043200.96735740
79Fanconi anemia pathway_Homo sapiens_hsa034600.96263688
80Tight junction_Homo sapiens_hsa045300.96147565
81Glioma_Homo sapiens_hsa052140.95531654
82Fatty acid elongation_Homo sapiens_hsa000620.92329656
83cAMP signaling pathway_Homo sapiens_hsa040240.92246351
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.91791113
85MicroRNAs in cancer_Homo sapiens_hsa052060.90388354
86Dilated cardiomyopathy_Homo sapiens_hsa054140.90102547
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87458173
88Thyroid hormone synthesis_Homo sapiens_hsa049180.87316445
89Pyrimidine metabolism_Homo sapiens_hsa002400.87129597
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86129871
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85833098
92RNA transport_Homo sapiens_hsa030130.85222730
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84840522
94Fatty acid degradation_Homo sapiens_hsa000710.84679501
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84455144
96beta-Alanine metabolism_Homo sapiens_hsa004100.84109870
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83717923
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82160346
99Melanoma_Homo sapiens_hsa052180.79944132
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79926145
101N-Glycan biosynthesis_Homo sapiens_hsa005100.79773073
102ErbB signaling pathway_Homo sapiens_hsa040120.79439479
103Type II diabetes mellitus_Homo sapiens_hsa049300.78934496
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77396075
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77248882
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.76999600
107Carbon metabolism_Homo sapiens_hsa012000.76216163
108Biosynthesis of amino acids_Homo sapiens_hsa012300.74761377
109mTOR signaling pathway_Homo sapiens_hsa041500.73223429
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73042142
111Pyruvate metabolism_Homo sapiens_hsa006200.71088948
112Glutathione metabolism_Homo sapiens_hsa004800.71082456
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.70118466
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69963219
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65305987
116Thyroid cancer_Homo sapiens_hsa052160.65225050
117Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62900614
118Cell cycle_Homo sapiens_hsa041100.62340167
119Fatty acid biosynthesis_Homo sapiens_hsa000610.59505381
120Colorectal cancer_Homo sapiens_hsa052100.58217245
121TGF-beta signaling pathway_Homo sapiens_hsa043500.58002034
122Basal transcription factors_Homo sapiens_hsa030220.57905525
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57591287
124MAPK signaling pathway_Homo sapiens_hsa040100.57238576
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57130263
126Bladder cancer_Homo sapiens_hsa052190.55666121
127Endometrial cancer_Homo sapiens_hsa052130.53592658
128Prostate cancer_Homo sapiens_hsa052150.53228670
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52780375
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51060731
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50565349
132Oxidative phosphorylation_Homo sapiens_hsa001900.50295686
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49319619
134Alzheimers disease_Homo sapiens_hsa050100.48657733
135ECM-receptor interaction_Homo sapiens_hsa045120.48569152
136Rap1 signaling pathway_Homo sapiens_hsa040150.46744672
137Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46713997
138Adherens junction_Homo sapiens_hsa045200.46708258
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46589918
140Inositol phosphate metabolism_Homo sapiens_hsa005620.46548482
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46522397
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43191540
143Circadian rhythm_Homo sapiens_hsa047100.43147129
144Focal adhesion_Homo sapiens_hsa045100.40378979
145Small cell lung cancer_Homo sapiens_hsa052220.39783549
146Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36242208
147Metabolic pathways_Homo sapiens_hsa011000.35637365
148Folate biosynthesis_Homo sapiens_hsa007900.35163726
149Proteoglycans in cancer_Homo sapiens_hsa052050.32675515
150Peroxisome_Homo sapiens_hsa041460.31522059
151Pathways in cancer_Homo sapiens_hsa052000.27822930
152Retinol metabolism_Homo sapiens_hsa008300.24655221
153Tryptophan metabolism_Homo sapiens_hsa003800.24629045
154Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23587823
155Tyrosine metabolism_Homo sapiens_hsa003500.22627552
156Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21389084
157Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.18590593
158Histidine metabolism_Homo sapiens_hsa003400.18382369

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