WDR36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)4.78461231
2nucleobase biosynthetic process (GO:0046112)4.75761675
3protein localization to kinetochore (GO:0034501)4.65736492
4mitotic metaphase plate congression (GO:0007080)4.55356819
5nuclear pore complex assembly (GO:0051292)4.53981384
6purine nucleobase biosynthetic process (GO:0009113)4.52214464
7folic acid-containing compound biosynthetic process (GO:0009396)4.51114677
8DNA unwinding involved in DNA replication (GO:0006268)4.49259770
9mitotic nuclear envelope disassembly (GO:0007077)4.48107452
10IMP biosynthetic process (GO:0006188)4.42580421
11DNA replication initiation (GO:0006270)4.36075076
12non-recombinational repair (GO:0000726)4.34965424
13double-strand break repair via nonhomologous end joining (GO:0006303)4.34965424
14formation of translation preinitiation complex (GO:0001731)4.24613435
15nuclear envelope disassembly (GO:0051081)4.20672668
16membrane disassembly (GO:0030397)4.20672668
17maturation of SSU-rRNA (GO:0030490)4.18437644
18ribosome assembly (GO:0042255)4.15176406
19DNA replication-dependent nucleosome assembly (GO:0006335)4.14701332
20DNA replication-dependent nucleosome organization (GO:0034723)4.14701332
21DNA strand elongation involved in DNA replication (GO:0006271)4.11931737
22establishment of integrated proviral latency (GO:0075713)4.05763445
23IMP metabolic process (GO:0046040)3.99156390
24ribosome biogenesis (GO:0042254)3.96910403
25regulation of spindle organization (GO:0090224)3.93660095
26metaphase plate congression (GO:0051310)3.93594616
27DNA strand elongation (GO:0022616)3.93226590
28DNA replication checkpoint (GO:0000076)3.87074063
29protein localization to chromosome, centromeric region (GO:0071459)3.86889838
30regulation of centriole replication (GO:0046599)3.86275492
31positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.80173096
32positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.80173096
33positive regulation of mitotic sister chromatid separation (GO:1901970)3.80173096
34chromatin remodeling at centromere (GO:0031055)3.78383742
35CENP-A containing nucleosome assembly (GO:0034080)3.76369185
36regulation of translational fidelity (GO:0006450)3.71833990
37regulation of DNA endoreduplication (GO:0032875)3.71720186
38mitotic chromosome condensation (GO:0007076)3.65940728
39telomere maintenance via semi-conservative replication (GO:0032201)3.64545570
40tRNA aminoacylation for protein translation (GO:0006418)3.62985090
41amino acid activation (GO:0043038)3.60332256
42tRNA aminoacylation (GO:0043039)3.60332256
43ribosomal small subunit assembly (GO:0000028)3.57132040
44attachment of spindle microtubules to kinetochore (GO:0008608)3.55576188
45mitotic sister chromatid segregation (GO:0000070)3.55271397
46DNA double-strand break processing (GO:0000729)3.54243621
47DNA replication-independent nucleosome organization (GO:0034724)3.54231404
48DNA replication-independent nucleosome assembly (GO:0006336)3.54231404
49DNA topological change (GO:0006265)3.53562782
50ribonucleoprotein complex biogenesis (GO:0022613)3.52072686
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.49708245
52pore complex assembly (GO:0046931)3.47361546
53establishment of chromosome localization (GO:0051303)3.45616085
54ribosomal large subunit biogenesis (GO:0042273)3.44278783
55regulation of sister chromatid cohesion (GO:0007063)3.40318671
56telomere maintenance via recombination (GO:0000722)3.36544435
57kinetochore organization (GO:0051383)3.36519356
58sister chromatid segregation (GO:0000819)3.36258108
59mitotic recombination (GO:0006312)3.35751963
60regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.35342862
61regulation of mitotic spindle organization (GO:0060236)3.35084438
62DNA duplex unwinding (GO:0032508)3.31982973
63regulation of DNA damage checkpoint (GO:2000001)3.31900842
64DNA geometric change (GO:0032392)3.30530492
65positive regulation of chromosome segregation (GO:0051984)3.30464137
66rRNA methylation (GO:0031167)3.28389632
67regulation of helicase activity (GO:0051095)3.28332008
68nuclear envelope organization (GO:0006998)3.28022139
69negative regulation of DNA repair (GO:0045738)3.27161044
70spindle checkpoint (GO:0031577)3.26044945
71folic acid metabolic process (GO:0046655)3.24996780
72negative regulation of chromosome segregation (GO:0051985)3.24037183
73negative regulation of DNA recombination (GO:0045910)3.22949854
74negative regulation of mitotic sister chromatid separation (GO:2000816)3.21050111
75negative regulation of mitotic sister chromatid segregation (GO:0033048)3.21050111
76negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.21050111
77negative regulation of sister chromatid segregation (GO:0033046)3.21050111
78histone exchange (GO:0043486)3.20699156
79protein K6-linked ubiquitination (GO:0085020)3.20227240
80spindle assembly checkpoint (GO:0071173)3.18883600
81DNA ligation (GO:0006266)3.18261259
82* rRNA processing (GO:0006364)3.18211502
83mitotic spindle assembly checkpoint (GO:0007094)3.17795204
84regulation of chromosome segregation (GO:0051983)3.17384098
85telomere maintenance via telomere lengthening (GO:0010833)3.16652106
86mitotic spindle checkpoint (GO:0071174)3.16449065
87response to X-ray (GO:0010165)3.15948375
88negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.13704371
89regulation of mitotic metaphase/anaphase transition (GO:0030071)3.11193520
90mitochondrial RNA metabolic process (GO:0000959)3.11022658
91regulation of translational termination (GO:0006449)3.10008342
92somatic recombination of immunoglobulin gene segments (GO:0016447)3.09902605
93* rRNA metabolic process (GO:0016072)3.07877834
94negative regulation of DNA-dependent DNA replication (GO:2000104)3.07121688
95spliceosomal snRNP assembly (GO:0000387)3.06396134
96cellular protein complex localization (GO:0034629)3.06390972
97DNA conformation change (GO:0071103)3.05997907
98regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.05741280
99regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.04958720
100translational initiation (GO:0006413)3.03868773
101rRNA modification (GO:0000154)3.03448552
102telomere maintenance (GO:0000723)3.03029591
103regulation of centrosome cycle (GO:0046605)3.02643084
104sister chromatid cohesion (GO:0007062)3.02309672
105pre-miRNA processing (GO:0031054)3.02036098
106chromatin assembly or disassembly (GO:0006333)3.01260845
107maturation of 5.8S rRNA (GO:0000460)3.00851073
108histone H2A monoubiquitination (GO:0035518)3.00782065
109regulation of centrosome duplication (GO:0010824)3.00410260
110telomere organization (GO:0032200)2.97854482
111somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96561451
112somatic hypermutation of immunoglobulin genes (GO:0016446)2.96561451
113regulation of gene silencing by RNA (GO:0060966)2.95860609
114regulation of posttranscriptional gene silencing (GO:0060147)2.95860609
115regulation of gene silencing by miRNA (GO:0060964)2.95860609
116protein localization to chromosome (GO:0034502)2.95062906
117regulation of mitotic sister chromatid separation (GO:0010965)2.94434910
118regulation of mitotic sister chromatid segregation (GO:0033047)2.94434910
119regulation of sister chromatid segregation (GO:0033045)2.94434910
120mitotic sister chromatid cohesion (GO:0007064)2.93811870
121kinetochore assembly (GO:0051382)2.92411494
122translational termination (GO:0006415)2.91745212
123meiotic chromosome segregation (GO:0045132)2.90242161
124nucleotide-excision repair, DNA gap filling (GO:0006297)2.90233194
125regulation of histone H3-K9 methylation (GO:0051570)2.88671220
126heterochromatin organization (GO:0070828)2.84578170
127viral transcription (GO:0019083)2.83524720
128postreplication repair (GO:0006301)2.83182530
129anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.82023046
130termination of RNA polymerase I transcription (GO:0006363)2.81135250
131transcription-coupled nucleotide-excision repair (GO:0006283)2.80072133
132chromosome segregation (GO:0007059)2.78014217
133transcription elongation from RNA polymerase I promoter (GO:0006362)2.78006093

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.81279583
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.40518476
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.36689986
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.75236379
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.45778744
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.20051949
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.09235623
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.85331645
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.78551032
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66696249
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.63419207
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.56641971
13* GABP_17652178_ChIP-ChIP_JURKAT_Human2.55716647
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.55656569
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.52964170
16* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.45858607
17AR_21909140_ChIP-Seq_LNCAP_Human2.40373784
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.36600729
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.23458599
20* XRN2_22483619_ChIP-Seq_HELA_Human2.23367031
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12050443
22* VDR_23849224_ChIP-Seq_CD4+_Human2.11127712
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11068085
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.07831362
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.06474193
26MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00440614
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97271387
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95838464
29* DCP1A_22483619_ChIP-Seq_HELA_Human1.87346753
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86681299
31* FOXP3_21729870_ChIP-Seq_TREG_Human1.86435685
32* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85472184
33* GABP_19822575_ChIP-Seq_HepG2_Human1.79409616
34TTF2_22483619_ChIP-Seq_HELA_Human1.74493379
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71044716
36* ELK1_19687146_ChIP-ChIP_HELA_Human1.69813245
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.69570922
38MYC_22102868_ChIP-Seq_BL_Human1.69385429
39PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.67154400
40* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66083300
41FUS_26573619_Chip-Seq_HEK293_Human1.63462967
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61923313
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.58861374
44EWS_26573619_Chip-Seq_HEK293_Human1.58776243
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55907162
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54785862
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54195698
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54186158
49* KDM5A_27292631_Chip-Seq_BREAST_Human1.52400269
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52103244
51CIITA_25753668_ChIP-Seq_RAJI_Human1.50596873
52* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49129103
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.48890236
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47386215
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43707269
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40425051
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40168103
58* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39858698
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38716295
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.35830314
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35721993
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33787324
63SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.33714515
64* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30625039
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26410987
66TFEB_21752829_ChIP-Seq_HELA_Human1.24401788
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20433114
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20017084
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19939211
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.19502854
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18137717
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17769019
73GATA1_22025678_ChIP-Seq_K562_Human1.17449648
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.17036562
75YY1_21170310_ChIP-Seq_MESCs_Mouse1.16979838
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13298819
77* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12737079
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12182134
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11304316
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.10219015
81* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08734853
82FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.08619711
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08359363
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.06108264
85SOX17_20123909_ChIP-Seq_XEN_Mouse1.05938767
86* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05375612
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02832544
88ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02372461
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02173552
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98334027
91MYC_18940864_ChIP-ChIP_HL60_Human0.97658402
92* NANOG_16153702_ChIP-ChIP_HESCs_Human0.97472642
93FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97074558
94NANOG_21062744_ChIP-ChIP_HESCs_Human0.97058516
95TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95969411
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95939758
97* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95517435
98* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94780151
99* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93795834
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91882176
101NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90438041
102BRD4_25478319_ChIP-Seq_HGPS_Human0.89722843
103KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88911638
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.88911638
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88911638
106ELK1_22589737_ChIP-Seq_MCF10A_Human0.88843751
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88763420
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86837400
109SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85384498
110CHD1_26751641_Chip-Seq_LNCaP_Human0.84637368
111HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84026513
112PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.83137011
113CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83032744
114TAF15_26573619_Chip-Seq_HEK293_Human0.82797507
115WT1_19549856_ChIP-ChIP_CCG9911_Human0.82560654
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81641983
117SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.80847356
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80578900
119NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.80330609
120SMAD_19615063_ChIP-ChIP_OVARY_Human0.80255581
121PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77206463
122HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.74879147
123ELF5_23300383_ChIP-Seq_T47D_Human0.73740153
124* SOX2_16153702_ChIP-ChIP_HESCs_Human0.72984624
125CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.72821883
126EZH2_27294783_Chip-Seq_NPCs_Mouse0.69294670
127CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.69247929
128EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.69050992
129* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.68511026
130SALL4_22934838_ChIP-ChIP_CD34+_Human0.67499333

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.26886547
2MP0010094_abnormal_chromosome_stability4.59844654
3MP0003111_abnormal_nucleus_morphology4.37373706
4* MP0004957_abnormal_blastocyst_morpholog4.26225111
5MP0003077_abnormal_cell_cycle3.92519996
6MP0008057_abnormal_DNA_replication3.76355856
7MP0008058_abnormal_DNA_repair3.06183332
8MP0008007_abnormal_cellular_replicative2.86544393
9MP0010352_gastrointestinal_tract_polyps2.85786079
10MP0003123_paternal_imprinting2.69160922
11MP0001730_embryonic_growth_arrest2.55401477
12MP0008932_abnormal_embryonic_tissue2.49337846
13MP0000350_abnormal_cell_proliferation2.37141766
14MP0010307_abnormal_tumor_latency2.34960060
15MP0002396_abnormal_hematopoietic_system2.26545416
16MP0002009_preneoplasia2.26301658
17MP0008877_abnormal_DNA_methylation2.26099155
18MP0003786_premature_aging2.10206818
19MP0001672_abnormal_embryogenesis/_devel1.93780446
20MP0005380_embryogenesis_phenotype1.93780446
21MP0003718_maternal_effect1.92218021
22MP0001661_extended_life_span1.91635566
23MP0003806_abnormal_nucleotide_metabolis1.86229766
24MP0003705_abnormal_hypodermis_morpholog1.86083915
25MP0001697_abnormal_embryo_size1.81060948
26MP0003950_abnormal_plasma_membrane1.78651170
27MP0003984_embryonic_growth_retardation1.73850857
28MP0002088_abnormal_embryonic_growth/wei1.70919926
29MP0002006_tumorigenesis1.67883558
30* MP0002080_prenatal_lethality1.66818300
31MP0002085_abnormal_embryonic_tissue1.61035183
32MP0002084_abnormal_developmental_patter1.60235828
33MP0004197_abnormal_fetal_growth/weight/1.56728888
34MP0000490_abnormal_crypts_of1.56655465
35MP0002086_abnormal_extraembryonic_tissu1.56519146
36MP0004808_abnormal_hematopoietic_stem1.54841862
37MP0010678_abnormal_skin_adnexa1.46720009
38MP0003567_abnormal_fetal_cardiomyocyte1.40870201
39MP0002019_abnormal_tumor_incidence1.40092369
40MP0002166_altered_tumor_susceptibility1.39733360
41MP0005076_abnormal_cell_differentiation1.38427689
42MP0000313_abnormal_cell_death1.37155555
43MP0010030_abnormal_orbit_morphology1.35757191
44MP0003890_abnormal_embryonic-extraembry1.33081881
45MP0004233_abnormal_muscle_weight1.26393390
46MP0002210_abnormal_sex_determination1.25864656
47MP0003121_genomic_imprinting1.20742241
48MP0009053_abnormal_anal_canal1.16264838
49MP0006035_abnormal_mitochondrial_morpho1.09573012
50MP0001145_abnormal_male_reproductive1.07743587
51MP0005023_abnormal_wound_healing1.07098580
52MP0009333_abnormal_splenocyte_physiolog1.05567688
53MP0001293_anophthalmia1.04049546
54MP0005397_hematopoietic_system_phenotyp1.03447798
55MP0001545_abnormal_hematopoietic_system1.03447798
56MP0005187_abnormal_penis_morphology1.02824114
57MP0004272_abnormal_basement_membrane1.02529535
58MP0003315_abnormal_perineum_morphology1.00704084
59MP0000647_abnormal_sebaceous_gland0.99030751
60MP0000383_abnormal_hair_follicle0.98499549
61MP0000537_abnormal_urethra_morphology0.97925074
62MP0003566_abnormal_cell_adhesion0.97718713
63MP0003763_abnormal_thymus_physiology0.96502872
64MP0009672_abnormal_birth_weight0.95897860
65MP0000653_abnormal_sex_gland0.95831707
66MP0000703_abnormal_thymus_morphology0.93320998
67MP0003937_abnormal_limbs/digits/tail_de0.93259022
68MP0001929_abnormal_gametogenesis0.91968356
69MP0003941_abnormal_skin_development0.91619189
70MP0002060_abnormal_skin_morphology0.89702213
71MP0001119_abnormal_female_reproductive0.89212907
72MP0002111_abnormal_tail_morphology0.88976708
73MP0003119_abnormal_digestive_system0.88361248
74MP0000358_abnormal_cell_content/0.88033226
75MP0001915_intracranial_hemorrhage0.87921474
76MP0000569_abnormal_digit_pigmentation0.86580468
77MP0000858_altered_metastatic_potential0.85656771
78MP0005621_abnormal_cell_physiology0.85619857
79MP0003221_abnormal_cardiomyocyte_apopto0.85421592
80MP0000427_abnormal_hair_cycle0.85319377
81MP0002877_abnormal_melanocyte_morpholog0.85259894
82MP0006072_abnormal_retinal_apoptosis0.85131135
83MP0005384_cellular_phenotype0.84377591
84MP0004185_abnormal_adipocyte_glucose0.83638435
85MP0001216_abnormal_epidermal_layer0.83249886
86MP0002160_abnormal_reproductive_system0.82400732
87MP0002722_abnormal_immune_system0.80479376
88MP0000689_abnormal_spleen_morphology0.79426652
89MP0004134_abnormal_chest_morphology0.79351697
90MP0002398_abnormal_bone_marrow0.78235581
91MP0006054_spinal_hemorrhage0.74771414
92MP0000372_irregular_coat_pigmentation0.74606007
93MP0005408_hypopigmentation0.73758339
94MP0005220_abnormal_exocrine_pancreas0.72900051
95MP0003943_abnormal_hepatobiliary_system0.71655098
96MP0005389_reproductive_system_phenotype0.71169300
97MP0000733_abnormal_muscle_development0.71047227
98MP0003385_abnormal_body_wall0.69649330
99MP0009703_decreased_birth_body0.69418480
100MP0002092_abnormal_eye_morphology0.69024174
101MP0001191_abnormal_skin_condition0.68109786
102MP0005623_abnormal_meninges_morphology0.67946860
103MP0002269_muscular_atrophy0.67491300
104MP0003868_abnormal_feces_composition0.67401427
105MP0002177_abnormal_outer_ear0.67400574
106MP0000477_abnormal_intestine_morphology0.65816342
107MP0003186_abnormal_redox_activity0.64941968
108MP0001286_abnormal_eye_development0.64749482
109MP0002132_abnormal_respiratory_system0.63978732
110MP0000377_abnormal_hair_follicle0.63933965
111MP0000428_abnormal_craniofacial_morphol0.63911126
112MP0003699_abnormal_female_reproductive0.63698301
113MP0004264_abnormal_extraembryonic_tissu0.62468096
114MP0002429_abnormal_blood_cell0.59570027
115MP0005395_other_phenotype0.58988746
116MP0002938_white_spotting0.58724740
117MP0003115_abnormal_respiratory_system0.58696573
118MP0001849_ear_inflammation0.58065815
119MP0002653_abnormal_ependyma_morphology0.57812900
120MP0000750_abnormal_muscle_regeneration0.57119928
121MP0001881_abnormal_mammary_gland0.56724234
122MP0003656_abnormal_erythrocyte_physiolo0.56351578
123MP0000627_abnormal_mammary_gland0.56204158
124MP0005501_abnormal_skin_physiology0.56126223
125MP0002697_abnormal_eye_size0.55858351
126MP0009697_abnormal_copulation0.55669680
127MP0002102_abnormal_ear_morphology0.55230926
128MP0000432_abnormal_head_morphology0.54951670
129MP0001919_abnormal_reproductive_system0.54104878
130MP0010234_abnormal_vibrissa_follicle0.54099367
131MP0009278_abnormal_bone_marrow0.52907984
132MP0005266_abnormal_metabolism0.52600091
133MP0003936_abnormal_reproductive_system0.51442704
134MP0002925_abnormal_cardiovascular_devel0.49776999
135MP0003935_abnormal_craniofacial_develop0.49120125

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.84181480
2Breast hypoplasia (HP:0003187)3.69516791
3Chromsome breakage (HP:0040012)3.66032831
4Colon cancer (HP:0003003)3.54707756
5Selective tooth agenesis (HP:0001592)3.53458380
6Reticulocytopenia (HP:0001896)3.40577693
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.31989848
8Abnormality of the anterior horn cell (HP:0006802)3.25578105
9Degeneration of anterior horn cells (HP:0002398)3.25578105
10Nephroblastoma (Wilms tumor) (HP:0002667)3.19737037
11Ependymoma (HP:0002888)3.17846456
12Abnormality of the labia minora (HP:0012880)3.13858870
13Patellar aplasia (HP:0006443)3.12062953
14Oral leukoplakia (HP:0002745)3.08669600
15Carpal bone hypoplasia (HP:0001498)3.01095515
16Embryonal renal neoplasm (HP:0011794)3.00622288
17Medulloblastoma (HP:0002885)2.97616936
18Abnormality of chromosome stability (HP:0003220)2.96233043
19Aplasia/Hypoplasia of the patella (HP:0006498)2.94296534
20Volvulus (HP:0002580)2.90197136
2111 pairs of ribs (HP:0000878)2.85394253
22Impulsivity (HP:0100710)2.83656522
23Abnormality of methionine metabolism (HP:0010901)2.83529825
24Papillary thyroid carcinoma (HP:0002895)2.83407019
25Rhabdomyosarcoma (HP:0002859)2.80728240
26Rough bone trabeculation (HP:0100670)2.80655697
27Agnosia (HP:0010524)2.62943310
28Microvesicular hepatic steatosis (HP:0001414)2.62664701
29Meckel diverticulum (HP:0002245)2.60210995
30Thyroid carcinoma (HP:0002890)2.57268735
31Neoplasm of the pancreas (HP:0002894)2.56782218
32Abnormality of the preputium (HP:0100587)2.56121909
33Aplastic anemia (HP:0001915)2.55772036
34Absent radius (HP:0003974)2.55443726
35Deviation of the thumb (HP:0009603)2.55046034
36Abnormality of cells of the erythroid lineage (HP:0012130)2.54856469
37Myelodysplasia (HP:0002863)2.53911322
38Absent thumb (HP:0009777)2.52740638
39Missing ribs (HP:0000921)2.48834176
40Abnormality of the ileum (HP:0001549)2.42571459
41Cerebral hypomyelination (HP:0006808)2.42497720
42Proximal placement of thumb (HP:0009623)2.40600680
43Acute myeloid leukemia (HP:0004808)2.38697549
44Squamous cell carcinoma (HP:0002860)2.36693479
45Abnormal number of erythroid precursors (HP:0012131)2.36420880
46Premature ovarian failure (HP:0008209)2.35931105
47Absent forearm bone (HP:0003953)2.34955204
48Aplasia involving forearm bones (HP:0009822)2.34955204
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.34850900
50Abnormality of the calcaneus (HP:0008364)2.34144273
51Trismus (HP:0000211)2.32318545
52Small intestinal stenosis (HP:0012848)2.32128329
53Duodenal stenosis (HP:0100867)2.32128329
54Cortical dysplasia (HP:0002539)2.31357926
55Abnormality of the carotid arteries (HP:0005344)2.29121546
56Progressive external ophthalmoplegia (HP:0000590)2.28801166
57Supernumerary spleens (HP:0009799)2.28549633
58Neoplasm of the adrenal cortex (HP:0100641)2.27691203
59Biliary tract neoplasm (HP:0100574)2.26706549
60Entropion (HP:0000621)2.26235136
61Abnormal lung lobation (HP:0002101)2.25873648
62Pancreatic islet-cell hyperplasia (HP:0004510)2.24914569
63Basal cell carcinoma (HP:0002671)2.22788732
64Ankle contracture (HP:0006466)2.22152205
65Secondary amenorrhea (HP:0000869)2.21165847
66Facial hemangioma (HP:0000329)2.19311493
67Microretrognathia (HP:0000308)2.19098058
68Premature graying of hair (HP:0002216)2.17746357
69Sloping forehead (HP:0000340)2.15302956
70Deep philtrum (HP:0002002)2.15131141
71Horseshoe kidney (HP:0000085)2.13073927
72Abnormality of glycolysis (HP:0004366)2.13006624
73Clubbing of toes (HP:0100760)2.12961889
74Pelvic girdle muscle weakness (HP:0003749)2.12841958
75Multiple enchondromatosis (HP:0005701)2.11997622
76Glossoptosis (HP:0000162)2.11386662
77Bone marrow hypocellularity (HP:0005528)2.11169419
78Thrombocytosis (HP:0001894)2.11114653
79Neoplasm of the small intestine (HP:0100833)2.11037192
80Astrocytoma (HP:0009592)2.10955924
81Abnormality of the astrocytes (HP:0100707)2.10955924
82Ankyloglossia (HP:0010296)2.09169081
83Ectopic kidney (HP:0000086)2.07542588
84Abnormal auditory evoked potentials (HP:0006958)2.06252187
85Increased serum pyruvate (HP:0003542)2.04504078
86Submucous cleft hard palate (HP:0000176)2.03200402
87Neoplasm of the colon (HP:0100273)2.02346592
88Hypoglycemic seizures (HP:0002173)2.01408506
89Orthostatic hypotension (HP:0001278)2.00639131
90Abnormal trabecular bone morphology (HP:0100671)2.00438298
91Abnormality of the duodenum (HP:0002246)2.00019844
92Amaurosis fugax (HP:0100576)1.98762463
93Neoplasm of the adrenal gland (HP:0100631)1.98438115
94Atrophy/Degeneration involving motor neurons (HP:0007373)1.97960974
95Arteriovenous malformation (HP:0100026)1.96610948
96Sensory axonal neuropathy (HP:0003390)1.96447741
97Atresia of the external auditory canal (HP:0000413)1.95554326
98Glioma (HP:0009733)1.94772894
99Cafe-au-lait spot (HP:0000957)1.94732063
100Cellular immunodeficiency (HP:0005374)1.94661592
101Cutaneous melanoma (HP:0012056)1.94538911
102Macrocytic anemia (HP:0001972)1.93351627
103Abnormality of chromosome segregation (HP:0002916)1.93318579
104Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.92425957
105Prominent nose (HP:0000448)1.91494989
106Slender long bone (HP:0003100)1.90301685
107Termporal pattern (HP:0011008)1.89385208
108Insidious onset (HP:0003587)1.89385208
109Uterine neoplasm (HP:0010784)1.88394417
110Pallor (HP:0000980)1.88308159
111Abnormality of pyrimidine metabolism (HP:0004353)1.88162561
112Abnormal biliary tract morphology (HP:0012440)1.87973443
113Stillbirth (HP:0003826)1.86880176
114Shoulder girdle muscle weakness (HP:0003547)1.85967959
115Breast carcinoma (HP:0003002)1.85354234
116Aplasia/hypoplasia of the humerus (HP:0006507)1.84130262
117Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83786640
118Neoplasm of striated muscle (HP:0009728)1.83698751
119Ureteral duplication (HP:0000073)1.83421241
120Tracheoesophageal fistula (HP:0002575)1.82278592
121High pitched voice (HP:0001620)1.82231392
122Abnormal number of incisors (HP:0011064)1.81579099
123Aplasia/Hypoplasia of the sternum (HP:0006714)1.81452628
124Choanal atresia (HP:0000453)1.81183360
125Increased nuchal translucency (HP:0010880)1.80112776
126Abnormal spermatogenesis (HP:0008669)1.78992713
127Curly hair (HP:0002212)1.78744373
128Ovarian neoplasm (HP:0100615)1.77993656
129Short thumb (HP:0009778)1.77887622
130Asymmetry of the thorax (HP:0001555)1.75190033
131Sandal gap (HP:0001852)1.74635749
132Abnormality of oral frenula (HP:0000190)1.74317146
133Overlapping toe (HP:0001845)1.73580529
134Poikiloderma (HP:0001029)1.72497694
135IgA deficiency (HP:0002720)1.72247094
136Meningioma (HP:0002858)1.72000342
137Microglossia (HP:0000171)1.70865140
138Freckling (HP:0001480)1.70700383
139Lymphoma (HP:0002665)1.68461049
140Embryonal neoplasm (HP:0002898)1.67891962
141Wrist flexion contracture (HP:0001239)1.67620951
142Abnormality of DNA repair (HP:0003254)1.67610905
143Symptomatic seizures (HP:0011145)1.67601411
144Cystic hygroma (HP:0000476)1.66756123
145Malignant gastrointestinal tract tumors (HP:0006749)1.66449315
146Gastrointestinal carcinoma (HP:0002672)1.66449315
147Abnormal foot bone ossification (HP:0010675)1.66435619
148Neoplasm of the rectum (HP:0100743)1.65387800
149Sparse lateral eyebrow (HP:0005338)1.64933277
150Melanoma (HP:0002861)1.64615855
151Short chin (HP:0000331)1.62648282
152Abnormality of the intrinsic pathway (HP:0010989)1.61891872
153Abnormality of the musculature of the pelvis (HP:0001469)1.61666730
154Abnormality of the hip-girdle musculature (HP:0001445)1.61666730
155Neoplasm of the peripheral nervous system (HP:0100007)1.59626165
156Abnormality of homocysteine metabolism (HP:0010919)1.59597864
157Homocystinuria (HP:0002156)1.59597864
158Duplicated collecting system (HP:0000081)1.58979162
159Neoplasm of the thyroid gland (HP:0100031)1.58861750

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.25114904
2BUB14.03128430
3CDC73.87551784
4EIF2AK13.13821858
5TSSK62.78964987
6NEK22.71529050
7TAF12.59817805
8ACVR1B2.52554619
9NEK12.42381733
10SRPK12.42125789
11TTK2.42040957
12MST42.41207954
13BRSK22.36341817
14PBK2.27280272
15EEF2K2.01013222
16PLK12.00183100
17TRIM281.99131408
18NME21.96932825
19MKNK11.92549520
20PASK1.90950024
21EPHA21.88854330
22EIF2AK31.84681091
23PLK31.82661686
24CDK121.82318860
25ERBB31.81510888
26PLK41.81223599
27RPS6KB21.80649514
28RPS6KA41.67486085
29AURKB1.66452100
30FLT31.60589302
31TGFBR11.60179440
32CDK71.53904195
33STK101.53858493
34ATR1.51715123
35PKN21.45331877
36MKNK21.45308348
37MAP3K81.41960346
38SCYL21.41471229
39TLK11.40984033
40CDK41.35035720
41TESK21.35021698
42NUAK11.34880889
43CHEK21.32246375
44MST1R1.29479055
45VRK11.25709949
46BRSK11.24313940
47BCR1.23012092
48CHEK11.21194274
49ZAK1.20854606
50DYRK31.17085728
51AURKA1.16571993
52FRK1.04180497
53STK31.00334335
54STK390.96837545
55MELK0.96584279
56CDK80.95156640
57PAK40.94905266
58ALK0.90565018
59MAP2K30.90446173
60ATM0.89679790
61PIM10.87837677
62VRK20.87271217
63LATS20.86015036
64STK38L0.84177386
65MAP3K30.82204868
66CDK20.81692394
67STK40.79127335
68MET0.78667555
69CLK10.78388657
70LRRK20.76334256
71MAP3K100.73946730
72LATS10.70666404
73CDK60.69533189
74TNIK0.69193213
75CSNK1G10.68536075
76PDK40.68475268
77PDK30.68475268
78PLK20.67467499
79TAOK20.67178714
80MAP3K40.63605357
81CSNK2A20.63238750
82STK160.62990424
83CCNB10.62570853
84CSNK1A1L0.60567705
85CDK10.59316753
86NLK0.57978792
87PAK10.57104887
88BRD40.57003978
89YES10.56909939
90TRPM70.53897763
91SMG10.53394171
92EIF2AK20.52663053
93CSNK2A10.52627079
94MAP4K10.51369915
95TEC0.51190466
96RAF10.50497524
97BMPR1B0.49241207
98PIM20.48744475
99CSNK1G30.47769141
100MTOR0.47745193
101TTN0.47710601
102PAK20.46968551
103CDK30.46632636
104RPS6KA50.45542991
105TESK10.45498048
106NEK90.43412192
107MAPKAPK30.43369091
108JAK30.43303346
109PRKCI0.42925007
110NEK60.42692588
111PDK20.42043509
112BRAF0.41214564
113KSR10.38166679
114FGFR10.38039562
115AKT30.37385628
116CSNK1E0.36652877
117MAP3K140.33827568
118PNCK0.33573882
119ZAP700.31793646
120CSNK1G20.30985071
121TRIB30.30308631
122PRKDC0.30127478
123RPS6KB10.26574331
124MAP3K50.24667836
125AKT20.24514174
126CSNK1D0.23699357
127MARK30.23601086
128ERBB40.23280636
129CDK90.23132898
130KDR0.22436747
131STK240.21886475

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.38830422
2* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.18110910
3Mismatch repair_Homo sapiens_hsa034303.85153497
4RNA transport_Homo sapiens_hsa030133.49463641
5RNA polymerase_Homo sapiens_hsa030203.18568659
6One carbon pool by folate_Homo sapiens_hsa006703.12937526
7Spliceosome_Homo sapiens_hsa030403.07367504
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.95943121
9Cell cycle_Homo sapiens_hsa041102.92425565
10Nucleotide excision repair_Homo sapiens_hsa034202.84912800
11Proteasome_Homo sapiens_hsa030502.78553634
12Base excision repair_Homo sapiens_hsa034102.73444603
13Homologous recombination_Homo sapiens_hsa034402.64939240
14Ribosome_Homo sapiens_hsa030102.61846760
15Pyrimidine metabolism_Homo sapiens_hsa002402.21550030
16Non-homologous end-joining_Homo sapiens_hsa034502.16256581
17Fanconi anemia pathway_Homo sapiens_hsa034602.05365793
18Basal transcription factors_Homo sapiens_hsa030222.00365593
19RNA degradation_Homo sapiens_hsa030181.93384117
20mRNA surveillance pathway_Homo sapiens_hsa030151.87174314
21p53 signaling pathway_Homo sapiens_hsa041151.76928523
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.76584063
23Propanoate metabolism_Homo sapiens_hsa006401.47634118
24Systemic lupus erythematosus_Homo sapiens_hsa053221.35893023
25Vitamin B6 metabolism_Homo sapiens_hsa007501.32594662
26Selenocompound metabolism_Homo sapiens_hsa004501.26828690
27Epstein-Barr virus infection_Homo sapiens_hsa051691.25345411
28Pyruvate metabolism_Homo sapiens_hsa006201.19802781
29Viral carcinogenesis_Homo sapiens_hsa052031.18416777
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18322437
31Purine metabolism_Homo sapiens_hsa002301.16293762
32Antigen processing and presentation_Homo sapiens_hsa046121.11762773
33Biosynthesis of amino acids_Homo sapiens_hsa012301.05173647
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.03903336
35Oocyte meiosis_Homo sapiens_hsa041141.01943467
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01495561
37Drug metabolism - other enzymes_Homo sapiens_hsa009830.98034204
38Pentose phosphate pathway_Homo sapiens_hsa000300.90043811
39Herpes simplex infection_Homo sapiens_hsa051680.89638066
40Cyanoamino acid metabolism_Homo sapiens_hsa004600.88979401
41Steroid biosynthesis_Homo sapiens_hsa001000.86438795
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84973208
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84762257
44HTLV-I infection_Homo sapiens_hsa051660.81249287
45Folate biosynthesis_Homo sapiens_hsa007900.80957402
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80546963
47MicroRNAs in cancer_Homo sapiens_hsa052060.79394379
48Small cell lung cancer_Homo sapiens_hsa052220.78920464
49Thyroid cancer_Homo sapiens_hsa052160.77731016
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75361017
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69366796
52Legionellosis_Homo sapiens_hsa051340.63079139
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61912263
54Sulfur relay system_Homo sapiens_hsa041220.61734003
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57774094
56Carbon metabolism_Homo sapiens_hsa012000.57563777
57TGF-beta signaling pathway_Homo sapiens_hsa043500.57029185
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54428862
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53074284
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49371669
61Apoptosis_Homo sapiens_hsa042100.48985543
62Hippo signaling pathway_Homo sapiens_hsa043900.47562187
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46859099
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46730702
65Circadian rhythm_Homo sapiens_hsa047100.44640314
66Fatty acid elongation_Homo sapiens_hsa000620.44466318
67Colorectal cancer_Homo sapiens_hsa052100.43759644
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.43705276
69Fatty acid metabolism_Homo sapiens_hsa012120.43693559
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41913519
71Bladder cancer_Homo sapiens_hsa052190.41850194
72Fatty acid biosynthesis_Homo sapiens_hsa000610.41414694
73Chronic myeloid leukemia_Homo sapiens_hsa052200.40780653
74Sulfur metabolism_Homo sapiens_hsa009200.40302343
75Alcoholism_Homo sapiens_hsa050340.39770190
76Hepatitis B_Homo sapiens_hsa051610.39203220
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38344044
78N-Glycan biosynthesis_Homo sapiens_hsa005100.37918798
79Glutathione metabolism_Homo sapiens_hsa004800.37423120
80HIF-1 signaling pathway_Homo sapiens_hsa040660.34662793
81Adherens junction_Homo sapiens_hsa045200.33746822
82Shigellosis_Homo sapiens_hsa051310.33041749
83mTOR signaling pathway_Homo sapiens_hsa041500.32162354
84Measles_Homo sapiens_hsa051620.30611249
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30279429
86Influenza A_Homo sapiens_hsa051640.28299165
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.27415916
88Notch signaling pathway_Homo sapiens_hsa043300.26047395
89Galactose metabolism_Homo sapiens_hsa000520.25028039
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24600511
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23814075
92Protein export_Homo sapiens_hsa030600.23221708
93Prostate cancer_Homo sapiens_hsa052150.22867444
94Wnt signaling pathway_Homo sapiens_hsa043100.21902214
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21857756
96Fructose and mannose metabolism_Homo sapiens_hsa000510.21324847
97Arginine biosynthesis_Homo sapiens_hsa002200.21167590
98Pathways in cancer_Homo sapiens_hsa052000.20620454
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20614330
100Viral myocarditis_Homo sapiens_hsa054160.20068948
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.20043022
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18206657
103Glioma_Homo sapiens_hsa052140.18196709
104Primary immunodeficiency_Homo sapiens_hsa053400.18170603
105FoxO signaling pathway_Homo sapiens_hsa040680.17642389
106Pancreatic cancer_Homo sapiens_hsa052120.17572552
107Proteoglycans in cancer_Homo sapiens_hsa052050.17413510
108Acute myeloid leukemia_Homo sapiens_hsa052210.16198661
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14978921
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.14690771
111Basal cell carcinoma_Homo sapiens_hsa052170.14022645
112Renin-angiotensin system_Homo sapiens_hsa046140.13120135
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.12670617
114Non-small cell lung cancer_Homo sapiens_hsa052230.12325068
115Melanoma_Homo sapiens_hsa052180.11863858
116Tight junction_Homo sapiens_hsa045300.11807718
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.10020563
118Metabolic pathways_Homo sapiens_hsa011000.09152632
119Endometrial cancer_Homo sapiens_hsa052130.08903986
120Lysine degradation_Homo sapiens_hsa003100.08431966

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