WDR37

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.41359438
2negative regulation of cell killing (GO:0031342)5.41359438
3positive regulation of gamma-delta T cell activation (GO:0046645)4.66185379
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.55396341
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.53828383
6synaptic vesicle exocytosis (GO:0016079)4.40682100
7neuron cell-cell adhesion (GO:0007158)4.35139291
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.31103337
9synaptic vesicle maturation (GO:0016188)4.29918262
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.24688839
11negative regulation of synaptic transmission, GABAergic (GO:0032229)4.24432892
12vocalization behavior (GO:0071625)4.19621155
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.16077050
14regulation of synaptic vesicle exocytosis (GO:2000300)4.08228687
15regulation of glutamate receptor signaling pathway (GO:1900449)4.05680104
16ionotropic glutamate receptor signaling pathway (GO:0035235)3.84647192
17protein localization to synapse (GO:0035418)3.84272767
18neuronal action potential propagation (GO:0019227)3.84202841
19membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.71040838
20glutamate secretion (GO:0014047)3.65365769
21gamma-aminobutyric acid signaling pathway (GO:0007214)3.62476683
22locomotory exploration behavior (GO:0035641)3.60905499
23regulation of synaptic vesicle transport (GO:1902803)3.58279452
24regulation of B cell receptor signaling pathway (GO:0050855)3.56745193
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.56376441
26neurotransmitter-gated ion channel clustering (GO:0072578)3.56229324
27macrophage activation involved in immune response (GO:0002281)3.56218213
28regulation of gamma-delta T cell activation (GO:0046643)3.56046774
29neurotransmitter secretion (GO:0007269)3.52505950
30synaptic vesicle docking involved in exocytosis (GO:0016081)3.50907344
31neuron-neuron synaptic transmission (GO:0007270)3.49447130
32presynaptic membrane assembly (GO:0097105)3.47574947
33glutamate receptor signaling pathway (GO:0007215)3.47531781
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.45885816
35negative regulation of T cell mediated immunity (GO:0002710)3.44282909
36response to peptidoglycan (GO:0032494)3.42728680
37synaptic transmission, glutamatergic (GO:0035249)3.42650310
38cellular extravasation (GO:0045123)3.38323929
39negative regulation of interleukin-12 production (GO:0032695)3.37758780
40regulation of gamma-delta T cell differentiation (GO:0045586)3.30954635
41negative regulation of lymphocyte mediated immunity (GO:0002707)3.30443964
42antigen processing and presentation of endogenous antigen (GO:0019883)3.28791671
43cerebellar Purkinje cell differentiation (GO:0021702)3.27616829
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.21980269
45detection of other organism (GO:0098543)3.21694169
46positive regulation by symbiont of host defense response (GO:0052509)3.21657909
47modulation by symbiont of host defense response (GO:0052031)3.21657909
48modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.21657909
49modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.21657909
50positive regulation by organism of defense response of other organism involved in symbiotic interact3.21657909
51modulation by symbiont of host immune response (GO:0052553)3.21657909
52startle response (GO:0001964)3.21532240
53synaptic vesicle endocytosis (GO:0048488)3.18186288
54activated T cell proliferation (GO:0050798)3.17118352
55presynaptic membrane organization (GO:0097090)3.16679918
56response to interleukin-15 (GO:0070672)3.15785232
57neutrophil activation involved in immune response (GO:0002283)3.14556295
58cellular response to interleukin-15 (GO:0071350)3.13907056
59negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.12979801
60antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.11272230
61leukocyte aggregation (GO:0070486)3.11214175
62gamma-aminobutyric acid transport (GO:0015812)3.09984447
63germinal center formation (GO:0002467)3.07805766
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.07691456
65regulation of T-helper 2 cell differentiation (GO:0045628)3.06502910
66response to muramyl dipeptide (GO:0032495)3.04422821
67response to pheromone (GO:0019236)3.03606082
68exploration behavior (GO:0035640)3.02019376
69long-term synaptic potentiation (GO:0060291)3.01372918
70regulation of synaptic transmission, glutamatergic (GO:0051966)3.00581494
71detection of bacterium (GO:0016045)2.99430209
72regulation of synaptic transmission, GABAergic (GO:0032228)2.97932277
73regulation of ARF protein signal transduction (GO:0032012)2.97155891
74negative regulation of erythrocyte differentiation (GO:0045647)2.97063249
75negative regulation of leukocyte mediated immunity (GO:0002704)2.96359688
76postsynaptic membrane organization (GO:0001941)2.96010079
77response to auditory stimulus (GO:0010996)2.93067628
78regulation of synapse structural plasticity (GO:0051823)2.91864675
79proline transport (GO:0015824)2.91662998
80membrane depolarization during action potential (GO:0086010)2.90505469
81neurotransmitter transport (GO:0006836)2.90392233
82neutrophil mediated immunity (GO:0002446)2.89881308
83neuron recognition (GO:0008038)2.89853662
84positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.89341836
85regulation of excitatory postsynaptic membrane potential (GO:0060079)2.88073885
86long-term memory (GO:0007616)2.85923703
87regulation of long-term neuronal synaptic plasticity (GO:0048169)2.84700405
88NIK/NF-kappaB signaling (GO:0038061)2.82066557
89response to histamine (GO:0034776)2.81876607
90regulation of neuronal synaptic plasticity (GO:0048168)2.81702451
91transmission of nerve impulse (GO:0019226)2.79667494
92regulation of postsynaptic membrane potential (GO:0060078)2.75404002
93regulation of neurotransmitter secretion (GO:0046928)2.74719774
94negative thymic T cell selection (GO:0045060)2.74397431
95detection of external biotic stimulus (GO:0098581)2.74035692
96positive regulation of membrane potential (GO:0045838)2.73154850
97regulation of mast cell degranulation (GO:0043304)2.72729231
98auditory behavior (GO:0031223)2.72369736
99detection of molecule of bacterial origin (GO:0032490)2.72152579
100myeloid leukocyte mediated immunity (GO:0002444)2.71567635
101regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.70166728
102membrane depolarization (GO:0051899)2.69834379
103positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.68954084
104regulation of dendritic spine morphogenesis (GO:0061001)2.68326837
105regulation of leukocyte degranulation (GO:0043300)2.68015580
106transferrin transport (GO:0033572)2.67294033
107positive regulation of dendritic spine morphogenesis (GO:0061003)2.67179043
108G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65834921
109positive regulation of granulocyte differentiation (GO:0030854)2.65594040
110negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.65371720
111vesicle transport along microtubule (GO:0047496)2.65350935
112positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.65303722
113neutrophil activation (GO:0042119)2.64554381
114layer formation in cerebral cortex (GO:0021819)2.64265014
115macrophage activation (GO:0042116)2.64058976
116regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.64040974
117negative T cell selection (GO:0043383)2.63333501
118adult walking behavior (GO:0007628)2.63324000
119B cell receptor signaling pathway (GO:0050853)2.61707438
120positive thymic T cell selection (GO:0045059)2.60897274
121regulation of vesicle fusion (GO:0031338)2.60409625
122positive regulation of mast cell activation (GO:0033005)2.60151031
123cellular response to nerve growth factor stimulus (GO:1990090)2.60044549
124response to nerve growth factor (GO:1990089)2.60044549
125positive regulation of synaptic transmission, GABAergic (GO:0032230)2.58650857
126mechanosensory behavior (GO:0007638)2.58089001
127regulation of synaptic plasticity (GO:0048167)2.57844479
128regulation of neurotransmitter levels (GO:0001505)2.57389175
129phagosome maturation (GO:0090382)2.57388368
130positive T cell selection (GO:0043368)2.57298865
131regulation of myeloid leukocyte mediated immunity (GO:0002886)2.57283620
132regulation of neurotransmitter transport (GO:0051588)2.56691066
133myeloid cell activation involved in immune response (GO:0002275)2.56157452
134regulation of mast cell activation involved in immune response (GO:0033006)2.55946003
135granulocyte activation (GO:0036230)2.55311891
136membrane hyperpolarization (GO:0060081)2.55277572
137T cell migration (GO:0072678)2.54997083
138positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.54851902
139synapse assembly (GO:0007416)2.54710761
140learning (GO:0007612)2.54567258
141L-amino acid import (GO:0043092)2.53187491
142regulation of interleukin-12 biosynthetic process (GO:0045075)2.53090852
143neuromuscular process controlling posture (GO:0050884)2.52803395
144synaptic transmission (GO:0007268)2.52743415
145axonal fasciculation (GO:0007413)2.52729549
146cellular potassium ion homeostasis (GO:0030007)2.52551901
147positive regulation of B cell differentiation (GO:0045579)2.52200551
148regulation of B cell differentiation (GO:0045577)2.51594491
149RNA destabilization (GO:0050779)2.50828694
150righting reflex (GO:0060013)2.50009949
151regulation of regulated secretory pathway (GO:1903305)2.49730834
152regulation of T cell tolerance induction (GO:0002664)2.49464762
153dendrite morphogenesis (GO:0048813)2.49289177
154regulation of T cell mediated cytotoxicity (GO:0001914)2.48490889
155regulation of tolerance induction (GO:0002643)2.47997478
156regulation of glutamate secretion (GO:0014048)2.47786182
157positive regulation of synapse assembly (GO:0051965)2.47166061
158ferric iron transport (GO:0015682)2.46997185
159trivalent inorganic cation transport (GO:0072512)2.46997185
160establishment of synaptic vesicle localization (GO:0097480)2.46212832
161synaptic vesicle transport (GO:0048489)2.46212832
162negative regulation of neurotransmitter transport (GO:0051589)2.45767495
163activation of protein kinase A activity (GO:0034199)2.45365186
164regulation of dendritic spine development (GO:0060998)2.45238698
165dendritic spine morphogenesis (GO:0060997)2.44732511
166regulation of mast cell activation (GO:0033003)2.44475335
167positive regulation of synaptic transmission (GO:0050806)2.43034612
168striatum development (GO:0021756)2.43000383
169negative regulation of dendrite morphogenesis (GO:0050774)2.42625923
170cerebellar granule cell differentiation (GO:0021707)2.42476892
171T cell selection (GO:0045058)2.42324193
172negative regulation of type 2 immune response (GO:0002829)2.40912165
173regulation of interferon-beta biosynthetic process (GO:0045357)2.39142822
174negative regulation of interleukin-17 production (GO:0032700)2.38599521
175negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.37507223
176response to host immune response (GO:0052572)2.37338296
177response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.37338296
178regulation of ARF GTPase activity (GO:0032312)2.36462356
179lipopolysaccharide-mediated signaling pathway (GO:0031663)2.36291836
180respiratory burst (GO:0045730)2.35870829
181positive regulation of Rap GTPase activity (GO:0032854)2.34359588
182detection of biotic stimulus (GO:0009595)2.33617356
183signal complex assembly (GO:0007172)2.32611607
184positive regulation of mast cell degranulation (GO:0043306)2.32163821
185positive regulation of mast cell activation involved in immune response (GO:0033008)2.32163821
186mannose metabolic process (GO:0006013)2.31250618
187histone H3-K36 demethylation (GO:0070544)2.29220482
188negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.27507691
189microglial cell activation (GO:0001774)2.25840392
190nerve growth factor signaling pathway (GO:0038180)2.24496503
191positive regulation of tolerance induction (GO:0002645)2.23434195
192regulation of granulocyte differentiation (GO:0030852)2.22914666
193positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.22393206
194protein localization to endosome (GO:0036010)2.20404673
195negative regulation of adaptive immune response (GO:0002820)2.19939046
196regulation of NFAT protein import into nucleus (GO:0051532)2.19585022
197cellular response to type I interferon (GO:0071357)2.19552513
198type I interferon signaling pathway (GO:0060337)2.19552513
199leukocyte degranulation (GO:0043299)2.19210791
200response to host defenses (GO:0052200)2.17582965

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.21003555
2GBX2_23144817_ChIP-Seq_PC3_Human3.89468687
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.44916828
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.22146325
5* FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.72711769
6RUNX_20019798_ChIP-Seq_JUKART_Human2.68142262
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.67962980
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.67666811
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60690692
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48902044
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46332057
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.45831705
13TAF15_26573619_Chip-Seq_HEK293_Human2.40163803
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37513702
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.36667084
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.33025572
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25883393
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16248724
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.15701087
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.14270871
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10256468
22SCL_19346495_ChIP-Seq_HPC-7_Human2.08088338
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06284679
24REST_21632747_ChIP-Seq_MESCs_Mouse2.04966671
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03919445
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.02918590
27KDM2B_26808549_Chip-Seq_SUP-B15_Human2.02346150
28SPI1_23127762_ChIP-Seq_K562_Human2.00237901
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.99384444
30SMAD4_21799915_ChIP-Seq_A2780_Human1.97479201
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.94624019
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.94624019
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.94100904
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92846831
35P300_19829295_ChIP-Seq_ESCs_Human1.92760880
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.89809536
37VDR_24763502_ChIP-Seq_THP-1_Human1.89771490
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88848499
39VDR_24787735_ChIP-Seq_THP-1_Human1.88152197
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.87312885
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86848448
42MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85764299
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85108303
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84949813
45VDR_21846776_ChIP-Seq_THP-1_Human1.84572038
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84413338
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.83374796
48AR_21572438_ChIP-Seq_LNCaP_Human1.79492782
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.78116734
50IGF1R_20145208_ChIP-Seq_DFB_Human1.74404640
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73774592
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.73620396
53* KDM2B_26808549_Chip-Seq_DND41_Human1.73468309
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73129773
55TCF7_22412390_ChIP-Seq_EML_Mouse1.72998483
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70864184
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70578192
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63627540
59DROSHA_22980978_ChIP-Seq_HELA_Human1.63148993
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62725698
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62024277
62MAF_26560356_Chip-Seq_TH1_Human1.61852558
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.59216294
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58458031
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.57309681
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57260620
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56939379
68FUS_26573619_Chip-Seq_HEK293_Human1.54753216
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53549238
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53539409
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.53434492
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52863208
73* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52716604
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.51843883
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51119689
76RNF2_27304074_Chip-Seq_NSC_Mouse1.50438930
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.50078611
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.49862900
79* GATA1_19941827_ChIP-Seq_MEL_Mouse1.49720246
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49613519
81UTX_26944678_Chip-Seq_JUKART_Human1.49132368
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48901298
83STAT3_23295773_ChIP-Seq_U87_Human1.48473886
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47086638
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46639625
86AR_25329375_ChIP-Seq_VCAP_Human1.45798730
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.45715950
88GATA1_19941826_ChIP-Seq_K562_Human1.45326428
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44948327
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44462038
91MYB_26560356_Chip-Seq_TH2_Human1.44458157
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43799624
93RARB_27405468_Chip-Seq_BRAIN_Mouse1.43792754
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.43388348
95IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43329994
96ER_23166858_ChIP-Seq_MCF-7_Human1.42304692
97FLI1_27457419_Chip-Seq_LIVER_Mouse1.42104217
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41824471
99EGR1_19374776_ChIP-ChIP_THP-1_Human1.41812646
100CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41286019
101IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41043953
102GATA3_27048872_Chip-Seq_THYMUS_Human1.39957138
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39639403
104RUNX1_22412390_ChIP-Seq_EML_Mouse1.36073644
105TCF4_23295773_ChIP-Seq_U87_Human1.35260516
106* SPI1_23547873_ChIP-Seq_NB4_Human1.34790218
107GATA2_21666600_ChIP-Seq_HMVEC_Human1.33991009
108SOX2_21211035_ChIP-Seq_LN229_Gbm1.33090854
109KDM2B_26808549_Chip-Seq_JURKAT_Human1.32667849
110E2F1_18555785_Chip-Seq_ESCs_Mouse1.30447560
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30149454
112PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28877792
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27534623
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26631663
115CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25467234
116MAF_26560356_Chip-Seq_TH2_Human1.25204191
117STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24513302
118ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24254361
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.24032025
120NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23429525
121VDR_22108803_ChIP-Seq_LS180_Human1.22631507
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21778120
123AHR_22903824_ChIP-Seq_MCF-7_Human1.21483710
124CMYC_18555785_Chip-Seq_ESCs_Mouse1.21289128
125* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21191980
126MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20965281
127P53_22387025_ChIP-Seq_ESCs_Mouse1.19981662
128SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19879893
129* KDM2B_26808549_Chip-Seq_K562_Human1.19825949
130MYB_26560356_Chip-Seq_TH1_Human1.18457372
131LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18193259
132PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18138968
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17243994
134* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17194892
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16608487
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16608487
137IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15979377
138SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15611469
139RUNX2_22187159_ChIP-Seq_PCA_Human1.15484138
140NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13059156
141BP1_19119308_ChIP-ChIP_Hs578T_Human1.12963656
142NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12831856
143P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11721868
144PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10647325
145SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10246092
146* PRDM14_20953172_ChIP-Seq_ESCs_Human1.08950016
147* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08935805
148MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07989497
149AR_19668381_ChIP-Seq_PC3_Human1.07572525
150KDM2B_26808549_Chip-Seq_REH_Human1.07104496
151EWS_26573619_Chip-Seq_HEK293_Human1.07089727
152NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06997218
153STAT3_18555785_Chip-Seq_ESCs_Mouse1.06088597
154GATA2_19941826_ChIP-Seq_K562_Human1.06008899
155* JUN_21703547_ChIP-Seq_K562_Human1.05878548
156* PU_27001747_Chip-Seq_BMDM_Mouse1.05604443
157MYC_22102868_ChIP-Seq_BL_Human1.04570176
158EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04533367
159YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03747869
160NMYC_18555785_Chip-Seq_ESCs_Mouse1.03739340
161LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03477695
162SOX2_18555785_Chip-Seq_ESCs_Mouse1.02371641
163LXR_22292898_ChIP-Seq_THP-1_Human1.00712655
164PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91189460
165ELK4_26923725_Chip-Seq_MESODERM_Mouse0.90287895
166BCL6_27268052_Chip-Seq_Bcells_Human0.90223458
167PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89842841
168GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89738619
169DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89043980
170GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88181420
171* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87902364
172SMRT_27268052_Chip-Seq_Bcells_Human0.87252871
173VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86548550
174BCOR_27268052_Chip-Seq_Bcells_Human0.86062482
175* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84817780
176ELK3_25401928_ChIP-Seq_HUVEC_Human0.84817545
177CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84192938
178EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83452887
179KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.82837293
180GATA3_26560356_Chip-Seq_TH2_Human0.79956839
181ELF1_20517297_ChIP-Seq_JURKAT_Human0.78428868
182RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.77902594
183PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77483195
184* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.75764821
185RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.75702424
186RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75512366
187* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74809226
188OCT4_19829295_ChIP-Seq_ESCs_Human0.74217395
189TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73779143

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.85003814
2MP0003880_abnormal_central_pattern4.27193452
3MP0003724_increased_susceptibility_to3.62256236
4MP0003635_abnormal_synaptic_transmissio3.55697146
5MP0009046_muscle_twitch3.53259680
6MP0003436_decreased_susceptibility_to3.47860320
7MP0009745_abnormal_behavioral_response3.15015908
8MP0004270_analgesia3.14695282
9MP0002064_seizures3.04735247
10MP0002063_abnormal_learning/memory/cond2.92138465
11MP0001486_abnormal_startle_reflex2.79835579
12MP0001968_abnormal_touch/_nociception2.69736343
13MP0002572_abnormal_emotion/affect_behav2.67723689
14MP0003787_abnormal_imprinting2.59735842
15MP0002735_abnormal_chemical_nociception2.57347571
16MP0001501_abnormal_sleep_pattern2.55650663
17MP0002272_abnormal_nervous_system2.52651216
18MP0002734_abnormal_mechanical_nocicepti2.50900847
19MP0002419_abnormal_innate_immunity2.50449542
20MP0000569_abnormal_digit_pigmentation2.46193441
21MP0006082_CNS_inflammation2.33553729
22MP0005000_abnormal_immune_tolerance2.25679332
23MP0002736_abnormal_nociception_after2.20489263
24MP0006276_abnormal_autonomic_nervous2.19607705
25MP0005423_abnormal_somatic_nervous2.18888231
26MP0005025_abnormal_response_to2.16373288
27MP0002067_abnormal_sensory_capabilities2.12837128
28MP0001800_abnormal_humoral_immune2.10371530
29MP0001790_abnormal_immune_system2.08816273
30MP0005387_immune_system_phenotype2.08816273
31MP0005451_abnormal_body_composition2.07266871
32MP0000604_amyloidosis2.04603094
33MP0009785_altered_susceptibility_to2.00680054
34MP0000685_abnormal_immune_system1.99871322
35MP0001440_abnormal_grooming_behavior1.99841867
36MP0002723_abnormal_immune_serum1.99752473
37MP0009278_abnormal_bone_marrow1.98427793
38MP0003300_gastrointestinal_ulcer1.97380554
39MP0003828_pulmonary_edema1.96001531
40MP0002420_abnormal_adaptive_immunity1.94945927
41MP0002452_abnormal_antigen_presenting1.93144380
42MP0001819_abnormal_immune_cell1.91706115
43MP0002733_abnormal_thermal_nociception1.85459972
44MP0003191_abnormal_cellular_cholesterol1.83296710
45MP0001984_abnormal_olfaction1.83225245
46MP0001970_abnormal_pain_threshold1.82266428
47MP0002822_catalepsy1.81437903
48MP0000778_abnormal_nervous_system1.81085093
49MP0003763_abnormal_thymus_physiology1.79741739
50MP0005646_abnormal_pituitary_gland1.79165804
51MP0004924_abnormal_behavior1.79122155
52MP0005386_behavior/neurological_phenoty1.79122155
53MP0005058_abnormal_lysosome_morphology1.75256723
54MP0005645_abnormal_hypothalamus_physiol1.74241565
55MP0002557_abnormal_social/conspecific_i1.73166107
56MP0002148_abnormal_hypersensitivity_rea1.68949845
57MP0001533_abnormal_skeleton_physiology1.67936190
58MP0002184_abnormal_innervation1.67240199
59MP0002405_respiratory_system_inflammati1.67211694
60MP0001188_hyperpigmentation1.64875696
61MP0004947_skin_inflammation1.63326132
62MP0003122_maternal_imprinting1.58188763
63MP0008569_lethality_at_weaning1.55389800
64MP0001529_abnormal_vocalization1.55146265
65MP0009840_abnormal_foam_cell1.53586091
66MP0004130_abnormal_muscle_cell1.51858268
67MP0004811_abnormal_neuron_physiology1.48552345
68MP0000716_abnormal_immune_system1.47422106
69MP0004510_myositis1.46380715
70MP0009780_abnormal_chondrocyte_physiolo1.44996779
71MP0001905_abnormal_dopamine_level1.42128981
72MP0005464_abnormal_platelet_physiology1.41487438
73MP0002398_abnormal_bone_marrow1.41287725
74MP0000465_gastrointestinal_hemorrhage1.40947746
75MP0003879_abnormal_hair_cell1.38518373
76MP0004742_abnormal_vestibular_system1.35613840
77MP0001502_abnormal_circadian_rhythm1.33863766
78MP0002882_abnormal_neuron_morphology1.33550328
79MP0004142_abnormal_muscle_tone1.31860326
80MP0002998_abnormal_bone_remodeling1.31507235
81MP0000955_abnormal_spinal_cord1.29035675
82MP0002066_abnormal_motor_capabilities/c1.27547794
83MP0003656_abnormal_erythrocyte_physiolo1.26284196
84MP0001845_abnormal_inflammatory_respons1.22548948
85MP0000689_abnormal_spleen_morphology1.20160996
86MP0010386_abnormal_urinary_bladder1.19466533
87MP0002722_abnormal_immune_system1.19110560
88MP0001545_abnormal_hematopoietic_system1.14917268
89MP0005397_hematopoietic_system_phenotyp1.14917268
90MP0005551_abnormal_eye_electrophysiolog1.14786817
91MP0002876_abnormal_thyroid_physiology1.13428439
92MP0004883_abnormal_blood_vessel1.13371633
93MP0001986_abnormal_taste_sensitivity1.13235649
94MP0005409_darkened_coat_color1.12010444
95MP0003866_abnormal_defecation1.10933159
96MP0009764_decreased_sensitivity_to1.07013884
97MP0008877_abnormal_DNA_methylation1.06671278
98MP0000703_abnormal_thymus_morphology1.05352625
99MP0003221_abnormal_cardiomyocyte_apopto1.05318861
100MP0003091_abnormal_cell_migration1.05026340
101MP0002429_abnormal_blood_cell1.01649255
102MP0001963_abnormal_hearing_physiology1.01284920
103MP0002229_neurodegeneration1.01032373
104MP0003633_abnormal_nervous_system1.00067171
105MP0008469_abnormal_protein_level0.99806918
106MP0010155_abnormal_intestine_physiology0.99306882
107MP0002102_abnormal_ear_morphology0.98787563
108MP0002638_abnormal_pupillary_reflex0.98672985
109MP0003646_muscle_fatigue0.98147456
110MP0003183_abnormal_peptide_metabolism0.97659408
111MP0003631_nervous_system_phenotype0.97069621
112MP0002152_abnormal_brain_morphology0.96420823
113MP0002163_abnormal_gland_morphology0.96372343
114MP0003045_fibrosis0.96170992
115MP0005410_abnormal_fertilization0.94887395
116MP0004858_abnormal_nervous_system0.94526432
117MP0005310_abnormal_salivary_gland0.93999783
118MP0003075_altered_response_to0.90393417
119MP0003121_genomic_imprinting0.90237361
120MP0003634_abnormal_glial_cell0.88681892
121MP0004484_altered_response_of0.87249535
122MP0000920_abnormal_myelination0.86844487
123MP0009333_abnormal_splenocyte_physiolog0.85796678
124MP0004885_abnormal_endolymph0.85629356
125MP0008260_abnormal_autophagy0.84907351
126MP0003690_abnormal_glial_cell0.84035706
127MP0005394_taste/olfaction_phenotype0.83305740
128MP0005499_abnormal_olfactory_system0.83305740
129MP0001851_eye_inflammation0.82620989
130MP0002277_abnormal_respiratory_mucosa0.82301213
131MP0002752_abnormal_somatic_nervous0.80560945
132MP0005171_absent_coat_pigmentation0.80069210
133MP0000343_altered_response_to0.79917789
134MP0000631_abnormal_neuroendocrine_gland0.78325775
135MP0004036_abnormal_muscle_relaxation0.78257230
136MP0005166_decreased_susceptibility_to0.77923150
137MP0005164_abnormal_response_to0.77337864
138MP0000015_abnormal_ear_pigmentation0.77049894
139MP0004381_abnormal_hair_follicle0.77026582
140MP0003632_abnormal_nervous_system0.76321078
141MP0005535_abnormal_body_temperature0.74739383
142MP0003303_peritoneal_inflammation0.73486356
143MP0000026_abnormal_inner_ear0.70862404
144MP0004808_abnormal_hematopoietic_stem0.70063357
145MP0002069_abnormal_eating/drinking_beha0.69027354
146MP0008874_decreased_physiological_sensi0.68597762
147MP0001348_abnormal_lacrimal_gland0.68420693
148MP0004085_abnormal_heartbeat0.65771867
149MP0003329_amyloid_beta_deposits0.65771141
150MP0002396_abnormal_hematopoietic_system0.65205066
151MP0000249_abnormal_blood_vessel0.64478270
152MP0000858_altered_metastatic_potential0.63921552
153MP0002971_abnormal_brown_adipose0.63404214
154MP0005671_abnormal_response_to0.62959869
155MP0002909_abnormal_adrenal_gland0.62834982
156MP0006072_abnormal_retinal_apoptosis0.62567448
157MP0005253_abnormal_eye_physiology0.62471993
158MP0005334_abnormal_fat_pad0.62217032
159MP0001835_abnormal_antigen_presentation0.61278807
160MP0004215_abnormal_myocardial_fiber0.59954789
161MP0001177_atelectasis0.57548361
162MP0002090_abnormal_vision0.57077937
163MP0002332_abnormal_exercise_endurance0.57050835
164MP0003172_abnormal_lysosome_physiology0.56099308
165MP0002009_preneoplasia0.53036550
166MP0001943_abnormal_respiration0.51579813

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.27834474
2Febrile seizures (HP:0002373)5.75599396
3Atonic seizures (HP:0010819)5.30420633
4Eczematoid dermatitis (HP:0000976)4.99738228
5Focal seizures (HP:0007359)4.92073072
6Epileptic encephalopathy (HP:0200134)4.67899169
7Recurrent bacterial skin infections (HP:0005406)4.36939492
8Myokymia (HP:0002411)4.36915148
9Progressive cerebellar ataxia (HP:0002073)4.26011464
10Abnormality of macrophages (HP:0004311)4.17461622
11Absence seizures (HP:0002121)4.13546626
12Recurrent abscess formation (HP:0002722)4.11396429
13Myositis (HP:0100614)3.77436879
14Dialeptic seizures (HP:0011146)3.74262077
15Generalized tonic-clonic seizures (HP:0002069)3.57998446
16Abnormal hair whorl (HP:0010721)3.44722019
17Asymmetric septal hypertrophy (HP:0001670)3.27215941
18Progressive inability to walk (HP:0002505)3.24398226
19Orchitis (HP:0100796)3.22760405
20Recurrent gram-negative bacterial infections (HP:0005420)3.15262926
21Visual hallucinations (HP:0002367)3.13507878
22Mediastinal lymphadenopathy (HP:0100721)3.10296921
23Recurrent fungal infections (HP:0002841)3.10166735
24T lymphocytopenia (HP:0005403)3.08139369
25Broad-based gait (HP:0002136)3.06729980
26Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.05584709
27Excessive salivation (HP:0003781)3.03041053
28Drooling (HP:0002307)3.03041053
29Dysostosis multiplex (HP:0000943)3.01198068
30Abnormality of liposaccharide metabolism (HP:0010968)3.01024006
31Abnormality of glycosphingolipid metabolism (HP:0004343)3.01024006
32Abnormality of glycolipid metabolism (HP:0010969)3.01024006
33Gaze-evoked nystagmus (HP:0000640)2.99397867
34Gingivitis (HP:0000230)2.93713055
35Neurofibrillary tangles (HP:0002185)2.87991090
36Recurrent skin infections (HP:0001581)2.87184490
37Spontaneous hematomas (HP:0007420)2.85748993
38Action tremor (HP:0002345)2.83674806
39Abnormality of T cell number (HP:0011839)2.80274218
40Chronic mucocutaneous candidiasis (HP:0002728)2.79609882
41Recurrent cutaneous fungal infections (HP:0011370)2.79609882
42Impaired vibration sensation in the lower limbs (HP:0002166)2.78079693
43Vacuolated lymphocytes (HP:0001922)2.76145676
44Increased cerebral lipofuscin (HP:0011813)2.76029774
45Elevated erythrocyte sedimentation rate (HP:0003565)2.74420118
46Mutism (HP:0002300)2.73993799
47Truncal ataxia (HP:0002078)2.73486560
48Gastrointestinal infarctions (HP:0005244)2.66112842
49Urinary bladder sphincter dysfunction (HP:0002839)2.64964817
50Abnormality of binocular vision (HP:0011514)2.64553472
51Diplopia (HP:0000651)2.64553472
52Hyperventilation (HP:0002883)2.62677287
53Abnormality of mucopolysaccharide metabolism (HP:0011020)2.60704380
54Abnormality of polysaccharide metabolism (HP:0011012)2.60704380
55Abnormality of glycosaminoglycan metabolism (HP:0004371)2.60704380
56Absent speech (HP:0001344)2.59989966
57Abnormal delayed hypersensitivity skin test (HP:0002963)2.57833283
58Mucopolysacchariduria (HP:0008155)2.57210048
59Urinary glycosaminoglycan excretion (HP:0003541)2.57210048
60Chest pain (HP:0100749)2.52767892
61Chronic obstructive pulmonary disease (HP:0006510)2.52550329
62Obstructive lung disease (HP:0006536)2.52550329
63Supranuclear gaze palsy (HP:0000605)2.51821531
64Genetic anticipation (HP:0003743)2.51693766
65Dysmetria (HP:0001310)2.48568607
66Increased IgE level (HP:0003212)2.45128903
67Inappropriate behavior (HP:0000719)2.42733897
68Ankle clonus (HP:0011448)2.42377211
69Dysdiadochokinesis (HP:0002075)2.41600945
70Cerebral inclusion bodies (HP:0100314)2.41591774
71Loss of speech (HP:0002371)2.41519205
72Limb dystonia (HP:0002451)2.40106552
73Meningitis (HP:0001287)2.39180333
74Hemiplegia (HP:0002301)2.37595362
75Difficulty running (HP:0009046)2.36608772
76Polyphagia (HP:0002591)2.35997976
77Postural instability (HP:0002172)2.34698386
78Leukocytosis (HP:0001974)2.34124413
79Abnormality of the corticospinal tract (HP:0002492)2.33248120
80Scanning speech (HP:0002168)2.33142550
81Hemiparesis (HP:0001269)2.32415032
82Abnormal eating behavior (HP:0100738)2.29553134
83Gait imbalance (HP:0002141)2.27243787
84Abnormality of salivation (HP:0100755)2.24615702
85Increased neuronal autofluorescent lipopigment (HP:0002074)2.20313735
86Vasculitis (HP:0002633)2.19098269
87Pustule (HP:0200039)2.19075156
88Blue irides (HP:0000635)2.18584326
89Fetal akinesia sequence (HP:0001989)2.16294998
90Encephalitis (HP:0002383)2.15324492
91Inability to walk (HP:0002540)2.15166000
92Absent/shortened dynein arms (HP:0200106)2.14998087
93Dynein arm defect of respiratory motile cilia (HP:0012255)2.14998087
94Amyotrophic lateral sclerosis (HP:0007354)2.14297886
95Papilledema (HP:0001085)2.14061149
96Apathy (HP:0000741)2.13412464
97Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.12695967
98Specific learning disability (HP:0001328)2.12322455
99Spastic gait (HP:0002064)2.12079385
100Urinary urgency (HP:0000012)2.11915757
101Hemoptysis (HP:0002105)2.11426969
102Agitation (HP:0000713)2.09468484
103Protruding tongue (HP:0010808)2.08711457
104Failure to thrive in infancy (HP:0001531)2.07934727
105Inflammation of the large intestine (HP:0002037)2.07537885
106Poor eye contact (HP:0000817)2.06819436
107Pulmonary infiltrates (HP:0002113)2.06625033
108Optic neuritis (HP:0100653)2.06496320
109Retrobulbar optic neuritis (HP:0100654)2.06496320
110Keratoconjunctivitis sicca (HP:0001097)2.06444321
111Widely spaced teeth (HP:0000687)2.05393143
112Esotropia (HP:0000565)2.05033475
113Diminished motivation (HP:0000745)2.04355416
114Slow saccadic eye movements (HP:0000514)2.01575377
115Depression (HP:0000716)2.01115536
116Cellulitis (HP:0100658)2.00829697
117Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00296870
118Anxiety (HP:0000739)2.00205807
119Pheochromocytoma (HP:0002666)1.99361408
120Gastrointestinal inflammation (HP:0004386)1.99306831
121Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.99068305
122Degeneration of the lateral corticospinal tracts (HP:0002314)1.99068305
123Epileptiform EEG discharges (HP:0011182)1.98995564
124Medial flaring of the eyebrow (HP:0010747)1.98534299
125Amblyopia (HP:0000646)1.98193671
126Impaired social interactions (HP:0000735)1.96350309
127Abnormal social behavior (HP:0012433)1.96350309
128Recurrent viral infections (HP:0004429)1.95415677
129Prolonged bleeding time (HP:0003010)1.94803316
130Congenital primary aphakia (HP:0007707)1.94406464
131Papillary thyroid carcinoma (HP:0002895)1.92014179
132Interstitial pulmonary disease (HP:0006530)1.91419318
133Keratoconjunctivitis (HP:0001096)1.91361854
134Amyloidosis (HP:0011034)1.90684104
135Neuronal loss in central nervous system (HP:0002529)1.90599812
136Impaired vibratory sensation (HP:0002495)1.89533672
137Lower limb muscle weakness (HP:0007340)1.87890001
138Gingival bleeding (HP:0000225)1.87700681
139EEG with generalized epileptiform discharges (HP:0011198)1.86849822
140Akinesia (HP:0002304)1.86273163
141Hematochezia (HP:0002573)1.86241091
142Colitis (HP:0002583)1.85832176
143Rapidly progressive (HP:0003678)1.83210508
144Epistaxis (HP:0000421)1.82741586
145Urticaria (HP:0001025)1.81942711
146Nephrogenic diabetes insipidus (HP:0009806)1.80986977
147Abnormality of eosinophils (HP:0001879)1.80663204
148Increased serum ferritin (HP:0003281)1.80084783
149Exotropia (HP:0000577)1.79028565
150Narrow nasal bridge (HP:0000446)1.79007244
151Insidious onset (HP:0003587)1.78952290
152Termporal pattern (HP:0011008)1.78952290
153Panhypogammaglobulinemia (HP:0003139)1.78084328
154Granulocytopenia (HP:0001913)1.77980348
155Hypothermia (HP:0002045)1.77611836
156Abnormality of saccadic eye movements (HP:0000570)1.77210618
157Increased CSF protein (HP:0002922)1.77066725
158Bradykinesia (HP:0002067)1.76867439
159Eosinophilia (HP:0001880)1.76624021
160Impaired smooth pursuit (HP:0007772)1.76218875
161Muscle fiber splitting (HP:0003555)1.75857179
162Hyperthyroidism (HP:0000836)1.75597496
163Abnormality of T cells (HP:0002843)1.74289848
164Episodic fever (HP:0001954)1.74242445
165Neuroendocrine neoplasm (HP:0100634)1.74150400
166Arterial thrombosis (HP:0004420)1.73272114
167Autoimmune thrombocytopenia (HP:0001973)1.73248084
168Hypsarrhythmia (HP:0002521)1.72902396
169Stereotypic behavior (HP:0000733)1.72248871
170Disinhibition (HP:0000734)1.71758367
171Psychosis (HP:0000709)1.71263004
172Incomplete penetrance (HP:0003829)1.70561383
173Gastroesophageal reflux (HP:0002020)1.69645802
174Sepsis (HP:0100806)1.68215315
175Abnormality of ocular smooth pursuit (HP:0000617)1.67947570
176Generalized myoclonic seizures (HP:0002123)1.67110595
177Genital tract atresia (HP:0001827)1.67090652
178Exercise-induced myalgia (HP:0003738)1.66411063
179Hypochromic anemia (HP:0001931)1.65664126
180Stomatitis (HP:0010280)1.65344598
181Abnormal ciliary motility (HP:0012262)1.62794440
182Aqueductal stenosis (HP:0002410)1.59644650
183Vaginal atresia (HP:0000148)1.59241275
184Hip dysplasia (HP:0001385)1.58246849

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.91277676
2NTRK33.75048954
3MAP2K73.47931073
4MAP3K43.36383232
5MARK12.86017882
6MAP3K92.42529987
7MAP3K122.35327511
8MAP4K12.16311626
9RIPK42.09926920
10TAOK32.09776536
11MAP2K32.01796197
12NTRK21.99757783
13MINK11.98936151
14ERN11.97347132
15MAPK131.89868908
16EPHA41.84977753
17SIK31.81776966
18EPHA31.81375148
19MAP2K41.78428747
20ZAP701.75695849
21TYK21.73258712
22EPHB11.67010557
23PLK21.64828414
24MAP3K111.63813858
25TNIK1.61317968
26CSK1.58473570
27PRPF4B1.55295941
28GRK71.54239114
29IRAK41.52407153
30SGK21.52220103
31MAP3K131.50948352
32JAK31.44489073
33GRK61.39622767
34MAP3K11.38241084
35BMPR21.36366572
36BCR1.34570112
37TAOK11.30139262
38IKBKE1.29555718
39HCK1.29188635
40PRKD21.28175406
41SGK4941.28161505
42SGK2231.28161505
43GRK51.26968387
44MAP3K141.26883535
45TBK11.26273166
46DAPK21.25024479
47FES1.24681376
48MAP3K31.24100028
49CAMK1G1.23260596
50PKN11.22147604
51CDK51.20748112
52ERBB31.20087135
53SIK21.18883668
54PAK61.16363966
55DYRK1B1.12104723
56MAPK121.09679473
57SGK31.07833847
58KSR11.07795962
59TAOK21.06681604
60BTK1.01724419
61AKT31.00467079
62CSF1R1.00370203
63PNCK0.98954789
64TXK0.98535322
65JAK20.97515940
66ARAF0.97092724
67MAP3K70.95505001
68CAMK2A0.93555925
69OXSR10.93476113
70CDK190.93306816
71FGFR30.91667419
72PRKCE0.89025421
73MARK30.88245320
74SGK10.88017802
75LCK0.87752343
76TIE10.87069771
77TTN0.85932673
78MAP3K50.85032270
79MAP3K60.84853851
80PRKCG0.84694252
81RIPK10.83783731
82TGFBR20.82799107
83WNK10.82236445
84STK380.81648584
85PRKCH0.80688108
86FGR0.79767200
87DAPK10.78036822
88UHMK10.77602548
89PIK3CG0.77143622
90PDPK10.76716789
91PTK2B0.76236879
92YES10.75590790
93LYN0.74569788
94ITK0.73876368
95CDC42BPA0.72983124
96IKBKB0.72113042
97DYRK1A0.68602048
98TESK20.68311323
99MATK0.66036729
100INSRR0.65821382
101TRIB30.65776827
102ERBB40.65685755
103RAF10.64033020
104NTRK10.63341298
105KSR20.63307302
106PHKG20.62781794
107PHKG10.62781794
108CAMKK10.62458219
109KIT0.61437506
110JAK10.61142324
111NEK60.60180709
112CAMK1D0.60107107
113BMPR1B0.59070065
114IRAK10.58961278
115STK110.58157401
116CDK30.58119912
117CAMK2B0.57698175
118HIPK20.57531940
119BLK0.57054649
120RPS6KL10.55953240
121RPS6KC10.55953240
122WNK30.55464322
123MAP3K20.55388625
124RPS6KA20.52397444
125CAMK10.52002664
126ADRBK20.51147263
127CSNK1G20.51037593
128PDK10.50921516
129PRKCQ0.49675350
130SYK0.47774961
131PRKD10.47668772
132CDK120.47336699
133MKNK20.47325555
134RET0.47115176
135PINK10.46988666
136DDR20.45862882
137MAPK40.45848408
138TNK20.45674713
139ICK0.45366141
140RPS6KA30.45159552
141FYN0.43349059
142CAMKK20.43213183
143PRKG10.42585343
144CDK180.41752808
145GRK10.41301786
146MARK20.40771612
147CCNB10.40076796
148PRKCZ0.38997653
149MAPK100.38765640
150MAPK70.38359526
151PRKCB0.36595314
152CAMK40.34630181
153PRKD30.34294747
154PBK0.34033415
155CDK140.33819038
156CDK150.32750848

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.45524775
2Synaptic vesicle cycle_Homo sapiens_hsa047212.90007802
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.42553950
4GABAergic synapse_Homo sapiens_hsa047272.31394807
5Morphine addiction_Homo sapiens_hsa050322.28171519
6Collecting duct acid secretion_Homo sapiens_hsa049662.17189520
7Olfactory transduction_Homo sapiens_hsa047402.15022509
8Circadian entrainment_Homo sapiens_hsa047132.09877279
9Glutamatergic synapse_Homo sapiens_hsa047242.03582898
10Long-term potentiation_Homo sapiens_hsa047201.90417915
11Other glycan degradation_Homo sapiens_hsa005111.74932830
12Amphetamine addiction_Homo sapiens_hsa050311.74467828
13Dopaminergic synapse_Homo sapiens_hsa047281.71970642
14Serotonergic synapse_Homo sapiens_hsa047261.67927914
15Type I diabetes mellitus_Homo sapiens_hsa049401.64438216
16Cholinergic synapse_Homo sapiens_hsa047251.61525481
17Salivary secretion_Homo sapiens_hsa049701.58598604
18Taste transduction_Homo sapiens_hsa047421.56412817
19Acute myeloid leukemia_Homo sapiens_hsa052211.55173990
20Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.52364990
21Rheumatoid arthritis_Homo sapiens_hsa053231.50825520
22Insulin secretion_Homo sapiens_hsa049111.44253519
23Long-term depression_Homo sapiens_hsa047301.41320814
24Renin secretion_Homo sapiens_hsa049241.40536427
25Staphylococcus aureus infection_Homo sapiens_hsa051501.32120458
26Oxytocin signaling pathway_Homo sapiens_hsa049211.30908085
27Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29617043
28Cocaine addiction_Homo sapiens_hsa050301.29009949
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28388463
30Type II diabetes mellitus_Homo sapiens_hsa049301.26631728
31Gastric acid secretion_Homo sapiens_hsa049711.24740694
32Calcium signaling pathway_Homo sapiens_hsa040201.24279191
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24198084
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22871287
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.20392265
36Lysosome_Homo sapiens_hsa041421.19962027
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19869662
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.19093828
39VEGF signaling pathway_Homo sapiens_hsa043701.17931358
40Vibrio cholerae infection_Homo sapiens_hsa051101.17247424
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16556919
42Toxoplasmosis_Homo sapiens_hsa051451.16488620
43Phototransduction_Homo sapiens_hsa047441.13527527
44GnRH signaling pathway_Homo sapiens_hsa049121.11813540
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11441609
46cAMP signaling pathway_Homo sapiens_hsa040241.08096610
47Primary immunodeficiency_Homo sapiens_hsa053401.07434236
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06076058
49Non-small cell lung cancer_Homo sapiens_hsa052231.05845425
50Dorso-ventral axis formation_Homo sapiens_hsa043201.05769459
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04245505
52ErbB signaling pathway_Homo sapiens_hsa040121.03054799
53Axon guidance_Homo sapiens_hsa043601.02608297
54Measles_Homo sapiens_hsa051621.01324765
55Malaria_Homo sapiens_hsa051441.00887931
56Platelet activation_Homo sapiens_hsa046110.99611780
57Influenza A_Homo sapiens_hsa051640.97188482
58Jak-STAT signaling pathway_Homo sapiens_hsa046300.95143411
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94474336
60Allograft rejection_Homo sapiens_hsa053300.93083401
61Legionellosis_Homo sapiens_hsa051340.92976328
62MAPK signaling pathway_Homo sapiens_hsa040100.92736152
63Pertussis_Homo sapiens_hsa051330.92005336
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.91074860
65Graft-versus-host disease_Homo sapiens_hsa053320.90841398
66Hematopoietic cell lineage_Homo sapiens_hsa046400.90322359
67Hepatitis B_Homo sapiens_hsa051610.90130751
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89294871
69Estrogen signaling pathway_Homo sapiens_hsa049150.88738611
70Chemokine signaling pathway_Homo sapiens_hsa040620.88142375
71Hepatitis C_Homo sapiens_hsa051600.87275701
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87051721
73Chronic myeloid leukemia_Homo sapiens_hsa052200.86113365
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86019111
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.85511545
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85428153
77Phagosome_Homo sapiens_hsa041450.84127051
78Shigellosis_Homo sapiens_hsa051310.82471422
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82125869
80Gap junction_Homo sapiens_hsa045400.81626110
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81227368
82Viral myocarditis_Homo sapiens_hsa054160.80473565
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79798970
84Antigen processing and presentation_Homo sapiens_hsa046120.77463673
85African trypanosomiasis_Homo sapiens_hsa051430.76663897
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76518317
87Glioma_Homo sapiens_hsa052140.74307364
88FoxO signaling pathway_Homo sapiens_hsa040680.73467071
89Osteoclast differentiation_Homo sapiens_hsa043800.72599081
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72464808
91Herpes simplex infection_Homo sapiens_hsa051680.72068960
92Inositol phosphate metabolism_Homo sapiens_hsa005620.71717178
93Ras signaling pathway_Homo sapiens_hsa040140.71484990
94Autoimmune thyroid disease_Homo sapiens_hsa053200.69255428
95Insulin resistance_Homo sapiens_hsa049310.68339713
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68298920
97Choline metabolism in cancer_Homo sapiens_hsa052310.67534696
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.66836892
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65980693
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65558409
101Melanogenesis_Homo sapiens_hsa049160.65521819
102Tuberculosis_Homo sapiens_hsa051520.64939642
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.64720496
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64474562
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.64138614
106Dilated cardiomyopathy_Homo sapiens_hsa054140.63903207
107Insulin signaling pathway_Homo sapiens_hsa049100.62423074
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62368660
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.62049903
110TNF signaling pathway_Homo sapiens_hsa046680.61859440
111T cell receptor signaling pathway_Homo sapiens_hsa046600.60890992
112Apoptosis_Homo sapiens_hsa042100.59954034
113Salmonella infection_Homo sapiens_hsa051320.59238423
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59025323
115Prolactin signaling pathway_Homo sapiens_hsa049170.58335316
116Colorectal cancer_Homo sapiens_hsa052100.56096006
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.56058223
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55095001
119Renal cell carcinoma_Homo sapiens_hsa052110.52563849
120Rap1 signaling pathway_Homo sapiens_hsa040150.51509434
121B cell receptor signaling pathway_Homo sapiens_hsa046620.49854352
122Oocyte meiosis_Homo sapiens_hsa041140.49702742
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48867608
124Cardiac muscle contraction_Homo sapiens_hsa042600.48329956
125Endocytosis_Homo sapiens_hsa041440.47976375
126Pancreatic secretion_Homo sapiens_hsa049720.47884879
127Endometrial cancer_Homo sapiens_hsa052130.45237511
128Ovarian steroidogenesis_Homo sapiens_hsa049130.44261554
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44182187
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42824603
131Alcoholism_Homo sapiens_hsa050340.42321230
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41653704
133Leishmaniasis_Homo sapiens_hsa051400.41611432
134mTOR signaling pathway_Homo sapiens_hsa041500.41293253
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40751912
136Pancreatic cancer_Homo sapiens_hsa052120.40609033
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39713470

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