

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 5.81398040 |
| 2 | nucleobase biosynthetic process (GO:0046112) | 5.09442255 |
| 3 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.99565170 |
| 4 | maturation of SSU-rRNA (GO:0030490) | 4.93960230 |
| 5 | DNA strand elongation (GO:0022616) | 4.78088649 |
| 6 | DNA unwinding involved in DNA replication (GO:0006268) | 4.74674148 |
| 7 | formation of translation preinitiation complex (GO:0001731) | 4.71097516 |
| 8 | purine nucleobase biosynthetic process (GO:0009113) | 4.64806663 |
| 9 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.54359231 |
| 10 | DNA replication initiation (GO:0006270) | 4.52871200 |
| 11 | folic acid-containing compound biosynthetic process (GO:0009396) | 4.51731417 |
| 12 | ribosomal small subunit assembly (GO:0000028) | 4.48895306 |
| 13 | nuclear pore complex assembly (GO:0051292) | 4.44633645 |
| 14 | regulation of translational fidelity (GO:0006450) | 4.41104449 |
| 15 | ribosome biogenesis (GO:0042254) | 4.38660319 |
| 16 | IMP biosynthetic process (GO:0006188) | 4.25439369 |
| 17 | viral transcription (GO:0019083) | 4.13234517 |
| 18 | mitotic sister chromatid segregation (GO:0000070) | 4.12697350 |
| 19 | mitotic chromosome condensation (GO:0007076) | 4.11561594 |
| 20 | DNA replication checkpoint (GO:0000076) | 4.11519727 |
| 21 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.09668772 |
| 22 | mitotic metaphase plate congression (GO:0007080) | 4.08572114 |
| 23 | translational termination (GO:0006415) | 4.08063107 |
| 24 | ribosome assembly (GO:0042255) | 4.01369263 |
| 25 | folic acid metabolic process (GO:0046655) | 4.00848297 |
| 26 | ribosomal large subunit biogenesis (GO:0042273) | 3.94863744 |
| 27 | pseudouridine synthesis (GO:0001522) | 3.91192847 |
| 28 | translational initiation (GO:0006413) | 3.90224382 |
| 29 | protein localization to kinetochore (GO:0034501) | 3.87869476 |
| 30 | translational elongation (GO:0006414) | 3.87360434 |
| 31 | spliceosomal snRNP assembly (GO:0000387) | 3.87242083 |
| 32 | telomere maintenance via recombination (GO:0000722) | 3.86014993 |
| 33 | mitotic nuclear envelope disassembly (GO:0007077) | 3.83036436 |
| 34 | ribosomal small subunit biogenesis (GO:0042274) | 3.77314924 |
| 35 | rRNA processing (GO:0006364) | 3.72240611 |
| 36 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 3.70504249 |
| 37 | sister chromatid segregation (GO:0000819) | 3.67478928 |
| 38 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.65820815 |
| 39 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.61121478 |
| 40 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.60895977 |
| 41 | IMP metabolic process (GO:0046040) | 3.60610673 |
| 42 | mitotic recombination (GO:0006312) | 3.60601289 |
| 43 | rRNA metabolic process (GO:0016072) | 3.59825182 |
| 44 | protein complex localization (GO:0031503) | 3.59552121 |
| 45 | telomere maintenance via telomere lengthening (GO:0010833) | 3.58707642 |
| 46 | nuclear envelope disassembly (GO:0051081) | 3.56034610 |
| 47 | membrane disassembly (GO:0030397) | 3.56034610 |
| 48 | proline biosynthetic process (GO:0006561) | 3.52587561 |
| 49 | cellular protein complex localization (GO:0034629) | 3.51792710 |
| 50 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.51699895 |
| 51 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.51699895 |
| 52 | establishment of integrated proviral latency (GO:0075713) | 3.49184554 |
| 53 | transcription from mitochondrial promoter (GO:0006390) | 3.42834150 |
| 54 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.42696071 |
| 55 | pore complex assembly (GO:0046931) | 3.42623146 |
| 56 | metaphase plate congression (GO:0051310) | 3.41675299 |
| 57 | negative regulation of RNA splicing (GO:0033119) | 3.38726665 |
| 58 | proteasome assembly (GO:0043248) | 3.37738481 |
| 59 | mitochondrial RNA metabolic process (GO:0000959) | 3.34517122 |
| 60 | protein targeting to ER (GO:0045047) | 3.30965805 |
| 61 | cotranslational protein targeting to membrane (GO:0006613) | 3.30684375 |
| 62 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.29032708 |
| 63 | DNA topological change (GO:0006265) | 3.25661580 |
| 64 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 3.24824085 |
| 65 | negative regulation of mRNA metabolic process (GO:1903312) | 3.24179493 |
| 66 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.23487230 |
| 67 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.23363314 |
| 68 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.21941952 |
| 69 | cellular protein complex disassembly (GO:0043624) | 3.20699435 |
| 70 | rRNA modification (GO:0000154) | 3.20060004 |
| 71 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.18427890 |
| 72 | protein localization to chromosome, centromeric region (GO:0071459) | 3.17599687 |
| 73 | rRNA transcription (GO:0009303) | 3.17136518 |
| 74 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.16776006 |
| 75 | termination of RNA polymerase III transcription (GO:0006386) | 3.16776006 |
| 76 | regulation of mitochondrial translation (GO:0070129) | 3.16444337 |
| 77 | viral life cycle (GO:0019058) | 3.15586839 |
| 78 | L-serine metabolic process (GO:0006563) | 3.15253440 |
| 79 | CENP-A containing nucleosome assembly (GO:0034080) | 3.15182757 |
| 80 | spliceosomal complex assembly (GO:0000245) | 3.13647171 |
| 81 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.13023201 |
| 82 | tRNA aminoacylation for protein translation (GO:0006418) | 3.12944770 |
| 83 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.12742902 |
| 84 | protein localization to endoplasmic reticulum (GO:0070972) | 3.11764675 |
| 85 | nuclear pore organization (GO:0006999) | 3.11636831 |
| 86 | regulation of translational termination (GO:0006449) | 3.11273826 |
| 87 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.10614829 |
| 88 | maturation of 5.8S rRNA (GO:0000460) | 3.09359340 |
| 89 | heterochromatin organization (GO:0070828) | 3.09067888 |
| 90 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.07772605 |
| 91 | cellular component biogenesis (GO:0044085) | 3.07745971 |
| 92 | amino acid activation (GO:0043038) | 3.07166371 |
| 93 | tRNA aminoacylation (GO:0043039) | 3.07166371 |
| 94 | negative regulation of mRNA processing (GO:0050686) | 3.07155157 |
| 95 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) | 3.06060214 |
| 96 | mRNA splicing, via spliceosome (GO:0000398) | 3.06060214 |
| 97 | chromatin remodeling at centromere (GO:0031055) | 3.05839554 |
| 98 | DNA duplex unwinding (GO:0032508) | 3.05004273 |
| 99 | RNA splicing, via transesterification reactions (GO:0000375) | 3.04581929 |
| 100 | protein complex disassembly (GO:0043241) | 3.03688853 |
| 101 | DNA geometric change (GO:0032392) | 3.02294197 |
| 102 | pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130) | 3.00875403 |
| 103 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.99878078 |
| 104 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.99351915 |
| 105 | DNA replication-independent nucleosome organization (GO:0034724) | 2.99351915 |
| 106 | translation (GO:0006412) | 2.99106854 |
| 107 | mitochondrial DNA metabolic process (GO:0032042) | 2.98259701 |
| 108 | termination of RNA polymerase II transcription (GO:0006369) | 2.98155949 |
| 109 | nuclear envelope organization (GO:0006998) | 2.97338545 |
| 110 | DNA conformation change (GO:0071103) | 2.97102744 |
| 111 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 2.96588565 |
| 112 | histone arginine methylation (GO:0034969) | 2.96245728 |
| 113 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.95296269 |
| 114 | negative regulation of ligase activity (GO:0051352) | 2.95296269 |
| 115 | establishment of chromosome localization (GO:0051303) | 2.94641966 |
| 116 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.93643657 |
| 117 | cell cycle G1/S phase transition (GO:0044843) | 2.93643657 |
| 118 | regulation of spindle organization (GO:0090224) | 2.93355835 |
| 119 | viral mRNA export from host cell nucleus (GO:0046784) | 2.91243244 |
| 120 | macromolecular complex disassembly (GO:0032984) | 2.89667958 |
| 121 | non-recombinational repair (GO:0000726) | 2.89226490 |
| 122 | double-strand break repair via nonhomologous end joining (GO:0006303) | 2.89226490 |
| 123 | peptidyl-arginine methylation (GO:0018216) | 2.88314112 |
| 124 | peptidyl-arginine N-methylation (GO:0035246) | 2.88314112 |
| 125 | * ncRNA processing (GO:0034470) | 2.88125306 |
| 126 | chromatin assembly or disassembly (GO:0006333) | 2.87904931 |
| 127 | base-excision repair (GO:0006284) | 2.87056867 |
| 128 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.85674027 |
| 129 | translesion synthesis (GO:0019985) | 2.84128224 |
| 130 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.83277804 |
| 131 | tetrahydrofolate metabolic process (GO:0046653) | 2.83264982 |
| 132 | RNA catabolic process (GO:0006401) | 2.83069940 |
| 133 | negative regulation of chromosome segregation (GO:0051985) | 2.81966378 |
| 134 | rRNA methylation (GO:0031167) | 2.80277050 |
| 135 | positive regulation of chromosome segregation (GO:0051984) | 2.78331856 |
| 136 | mitotic sister chromatid cohesion (GO:0007064) | 2.77828241 |
| 137 | chromosome segregation (GO:0007059) | 2.72256216 |
| 138 | regulation of translational elongation (GO:0006448) | 2.71766857 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.07091331 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.43268588 |
| 3 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.14063584 |
| 4 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.27769674 |
| 5 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.07975888 |
| 6 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.01091380 |
| 7 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.98234336 |
| 8 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.95048783 |
| 9 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.93996223 |
| 10 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.93187718 |
| 11 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.85088710 |
| 12 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.79935369 |
| 13 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.74866253 |
| 14 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.65832043 |
| 15 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.59470011 |
| 16 | * CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.53136444 |
| 17 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.47280722 |
| 18 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.24208733 |
| 19 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.17720333 |
| 20 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.07636781 |
| 21 | * GABP_19822575_ChIP-Seq_HepG2_Human | 2.07515941 |
| 22 | MYC_22102868_ChIP-Seq_BL_Human | 2.05736713 |
| 23 | CIITA_25753668_ChIP-Seq_RAJI_Human | 2.00631424 |
| 24 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.00371670 |
| 25 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.00022774 |
| 26 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.99146088 |
| 27 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.93518655 |
| 28 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.90956159 |
| 29 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.88035164 |
| 30 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.87917531 |
| 31 | * CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.85554646 |
| 32 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.84472077 |
| 33 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.77617352 |
| 34 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.76116829 |
| 35 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.75339875 |
| 36 | * POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.74907407 |
| 37 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.73966920 |
| 38 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.73050377 |
| 39 | * MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.67002934 |
| 40 | * PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.65308040 |
| 41 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.65057570 |
| 42 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.65028422 |
| 43 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.64403805 |
| 44 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.64002592 |
| 45 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.63907568 |
| 46 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.55085617 |
| 47 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.49367788 |
| 48 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.47620729 |
| 49 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.46087215 |
| 50 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.43387642 |
| 51 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.40350099 |
| 52 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.40007718 |
| 53 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.39476387 |
| 54 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.37592238 |
| 55 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.37519674 |
| 56 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.33206537 |
| 57 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.31975790 |
| 58 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.31240057 |
| 59 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.28577824 |
| 60 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.27514502 |
| 61 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.26341963 |
| 62 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.23638307 |
| 63 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.22630270 |
| 64 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.21251334 |
| 65 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.21023240 |
| 66 | * CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.20773642 |
| 67 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.20303947 |
| 68 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.19885180 |
| 69 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.19441233 |
| 70 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.17647736 |
| 71 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.13069768 |
| 72 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.12172468 |
| 73 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.12018782 |
| 74 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.11367937 |
| 75 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.11325475 |
| 76 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.10689098 |
| 77 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.10253549 |
| 78 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.08930270 |
| 79 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.08857418 |
| 80 | * ELK1_19687146_ChIP-ChIP_HELA_Human | 1.08733766 |
| 81 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.08647848 |
| 82 | * MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.07812494 |
| 83 | * CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.06221647 |
| 84 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.01666695 |
| 85 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.99998885 |
| 86 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.99708878 |
| 87 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.99166439 |
| 88 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.99028478 |
| 89 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.98171624 |
| 90 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.97598155 |
| 91 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.97191456 |
| 92 | * PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.96386126 |
| 93 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.95868692 |
| 94 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.95473278 |
| 95 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.94646750 |
| 96 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.93881334 |
| 97 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.93576304 |
| 98 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.93053613 |
| 99 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.91379464 |
| 100 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.91183068 |
| 101 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.90097764 |
| 102 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.89658114 |
| 103 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.89469760 |
| 104 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.89022550 |
| 105 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.88289104 |
| 106 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.87768480 |
| 107 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.87380598 |
| 108 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.85401714 |
| 109 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.84414319 |
| 110 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.84195706 |
| 111 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.83871701 |
| 112 | * TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.83047030 |
| 113 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.82042096 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.90153910 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 4.72172114 |
| 3 | MP0003111_abnormal_nucleus_morphology | 4.70159827 |
| 4 | MP0010094_abnormal_chromosome_stability | 4.24419057 |
| 5 | MP0003077_abnormal_cell_cycle | 4.05488981 |
| 6 | MP0008057_abnormal_DNA_replication | 3.38029357 |
| 7 | MP0008058_abnormal_DNA_repair | 3.14982068 |
| 8 | MP0008007_abnormal_cellular_replicative | 2.87855226 |
| 9 | MP0002396_abnormal_hematopoietic_system | 2.81034550 |
| 10 | MP0008932_abnormal_embryonic_tissue | 2.70213361 |
| 11 | MP0001730_embryonic_growth_arrest | 2.59453040 |
| 12 | MP0003123_paternal_imprinting | 2.42120315 |
| 13 | MP0000350_abnormal_cell_proliferation | 2.37987325 |
| 14 | MP0010352_gastrointestinal_tract_polyps | 2.31737508 |
| 15 | MP0005451_abnormal_body_composition | 2.10034607 |
| 16 | MP0004233_abnormal_muscle_weight | 2.05008195 |
| 17 | MP0001697_abnormal_embryo_size | 1.87102106 |
| 18 | MP0001672_abnormal_embryogenesis/_devel | 1.87026071 |
| 19 | MP0005380_embryogenesis_phenotype | 1.87026071 |
| 20 | MP0002080_prenatal_lethality | 1.86780362 |
| 21 | MP0000490_abnormal_crypts_of | 1.81842482 |
| 22 | MP0003786_premature_aging | 1.77671780 |
| 23 | MP0001293_anophthalmia | 1.76545952 |
| 24 | MP0003984_embryonic_growth_retardation | 1.72099619 |
| 25 | MP0004808_abnormal_hematopoietic_stem | 1.70650312 |
| 26 | MP0003718_maternal_effect | 1.70513702 |
| 27 | MP0002088_abnormal_embryonic_growth/wei | 1.68716220 |
| 28 | MP0008260_abnormal_autophagy | 1.64771491 |
| 29 | MP0004185_abnormal_adipocyte_glucose | 1.64568448 |
| 30 | MP0000313_abnormal_cell_death | 1.64000840 |
| 31 | MP0003806_abnormal_nucleotide_metabolis | 1.59841720 |
| 32 | MP0005501_abnormal_skin_physiology | 1.57873614 |
| 33 | MP0002085_abnormal_embryonic_tissue | 1.56718077 |
| 34 | MP0002796_impaired_skin_barrier | 1.53106128 |
| 35 | MP0005397_hematopoietic_system_phenotyp | 1.51672521 |
| 36 | MP0001545_abnormal_hematopoietic_system | 1.51672521 |
| 37 | MP0010307_abnormal_tumor_latency | 1.48643270 |
| 38 | MP0003567_abnormal_fetal_cardiomyocyte | 1.47331999 |
| 39 | MP0002019_abnormal_tumor_incidence | 1.46801083 |
| 40 | MP0009333_abnormal_splenocyte_physiolog | 1.46789470 |
| 41 | MP0002084_abnormal_developmental_patter | 1.46152946 |
| 42 | MP0002877_abnormal_melanocyte_morpholog | 1.46093957 |
| 43 | MP0002086_abnormal_extraembryonic_tissu | 1.43148066 |
| 44 | MP0001661_extended_life_span | 1.42342860 |
| 45 | MP0000358_abnormal_cell_content/ | 1.39794776 |
| 46 | MP0005076_abnormal_cell_differentiation | 1.38663265 |
| 47 | MP0010030_abnormal_orbit_morphology | 1.38428917 |
| 48 | MP0004197_abnormal_fetal_growth/weight/ | 1.34294089 |
| 49 | MP0009697_abnormal_copulation | 1.28811607 |
| 50 | MP0003890_abnormal_embryonic-extraembry | 1.27517911 |
| 51 | MP0000678_abnormal_parathyroid_gland | 1.20927599 |
| 52 | MP0003941_abnormal_skin_development | 1.20151970 |
| 53 | MP0003763_abnormal_thymus_physiology | 1.19573699 |
| 54 | MP0000703_abnormal_thymus_morphology | 1.19271323 |
| 55 | MP0003119_abnormal_digestive_system | 1.17301521 |
| 56 | MP0000537_abnormal_urethra_morphology | 1.14005557 |
| 57 | MP0003705_abnormal_hypodermis_morpholog | 1.10572320 |
| 58 | MP0002398_abnormal_bone_marrow | 1.09265900 |
| 59 | MP0009053_abnormal_anal_canal | 1.09197661 |
| 60 | MP0002722_abnormal_immune_system | 1.07450167 |
| 61 | MP0000689_abnormal_spleen_morphology | 1.03311180 |
| 62 | MP0003221_abnormal_cardiomyocyte_apopto | 1.00861700 |
| 63 | MP0006035_abnormal_mitochondrial_morpho | 1.00501365 |
| 64 | MP0008877_abnormal_DNA_methylation | 1.00473746 |
| 65 | MP0009840_abnormal_foam_cell | 0.98321082 |
| 66 | MP0002132_abnormal_respiratory_system | 0.97427473 |
| 67 | MP0006036_abnormal_mitochondrial_physio | 0.96264434 |
| 68 | MP0002111_abnormal_tail_morphology | 0.95488751 |
| 69 | MP0003453_abnormal_keratinocyte_physiol | 0.94769085 |
| 70 | MP0009672_abnormal_birth_weight | 0.94446916 |
| 71 | MP0005083_abnormal_biliary_tract | 0.92791216 |
| 72 | MP0002653_abnormal_ependyma_morphology | 0.91356050 |
| 73 | MP0005384_cellular_phenotype | 0.91280286 |
| 74 | MP0001873_stomach_inflammation | 0.91140263 |
| 75 | MP0003121_genomic_imprinting | 0.91091366 |
| 76 | MP0002092_abnormal_eye_morphology | 0.90378577 |
| 77 | MP0002429_abnormal_blood_cell | 0.90095423 |
| 78 | MP0009278_abnormal_bone_marrow | 0.90077062 |
| 79 | MP0003656_abnormal_erythrocyte_physiolo | 0.88326563 |
| 80 | MP0000858_altered_metastatic_potential | 0.83725826 |
| 81 | MP0002210_abnormal_sex_determination | 0.83504013 |
| 82 | MP0001145_abnormal_male_reproductive | 0.82803323 |
| 83 | MP0003315_abnormal_perineum_morphology | 0.82465549 |
| 84 | MP0005621_abnormal_cell_physiology | 0.81354188 |
| 85 | MP0006292_abnormal_olfactory_placode | 0.81144486 |
| 86 | MP0002060_abnormal_skin_morphology | 0.75976619 |
| 87 | MP0005075_abnormal_melanosome_morpholog | 0.75605473 |
| 88 | MP0000428_abnormal_craniofacial_morphol | 0.75219099 |
| 89 | MP0001881_abnormal_mammary_gland | 0.75043532 |
| 90 | MP0000477_abnormal_intestine_morphology | 0.74077885 |
| 91 | MP0001216_abnormal_epidermal_layer | 0.73775938 |
| 92 | MP0006054_spinal_hemorrhage | 0.73505041 |
| 93 | MP0000003_abnormal_adipose_tissue | 0.73057355 |
| 94 | MP0000598_abnormal_liver_morphology | 0.73050572 |
| 95 | MP0008770_decreased_survivor_rate | 0.72629151 |
| 96 | MP0002160_abnormal_reproductive_system | 0.71980769 |
| 97 | MP0004782_abnormal_surfactant_physiolog | 0.71902658 |
| 98 | MP0001915_intracranial_hemorrhage | 0.70662045 |
| 99 | MP0009931_abnormal_skin_appearance | 0.70340221 |
| 100 | MP0008995_early_reproductive_senescence | 0.70207241 |
| 101 | MP0000716_abnormal_immune_system | 0.67605956 |
| 102 | MP0005220_abnormal_exocrine_pancreas | 0.67553806 |
| 103 | MP0001346_abnormal_lacrimal_gland | 0.67129562 |
| 104 | MP0001849_ear_inflammation | 0.66544364 |
| 105 | MP0005023_abnormal_wound_healing | 0.65860307 |
| 106 | MP0003186_abnormal_redox_activity | 0.65633993 |
| 107 | MP0004264_abnormal_extraembryonic_tissu | 0.64557795 |
| 108 | MP0009379_abnormal_foot_pigmentation | 0.63679992 |
| 109 | MP0002254_reproductive_system_inflammat | 0.62314126 |
| 110 | MP0003699_abnormal_female_reproductive | 0.62260693 |
| 111 | MP0000653_abnormal_sex_gland | 0.61973958 |
| 112 | MP0002932_abnormal_joint_morphology | 0.60429378 |
| 113 | MP0009703_decreased_birth_body | 0.59961150 |
| 114 | MP0001853_heart_inflammation | 0.59214021 |
| 115 | MP0003283_abnormal_digestive_organ | 0.59194846 |
| 116 | MP0000750_abnormal_muscle_regeneration | 0.58302755 |
| 117 | MP0001727_abnormal_embryo_implantation | 0.57514763 |
| 118 | MP0001929_abnormal_gametogenesis | 0.57178364 |
| 119 | MP0005174_abnormal_tail_pigmentation | 0.56660514 |
| 120 | MP0010234_abnormal_vibrissa_follicle | 0.55635169 |
| 121 | MP0010630_abnormal_cardiac_muscle | 0.55610263 |
| 122 | MP0003937_abnormal_limbs/digits/tail_de | 0.55584483 |
| 123 | MP0001764_abnormal_homeostasis | 0.54564580 |
| 124 | MP0002089_abnormal_postnatal_growth/wei | 0.54516198 |
| 125 | MP0000733_abnormal_muscle_development | 0.54048667 |
| 126 | MP0005330_cardiomyopathy | 0.53719276 |
| 127 | MP0002697_abnormal_eye_size | 0.53581284 |
| 128 | MP0000579_abnormal_nail_morphology | 0.53087602 |
| 129 | MP0003566_abnormal_cell_adhesion | 0.52885826 |
| 130 | MP0000371_diluted_coat_color | 0.52843650 |
| 131 | MP0002970_abnormal_white_adipose | 0.51410849 |
| 132 | MP0001119_abnormal_female_reproductive | 0.51142544 |
| 133 | MP0002938_white_spotting | 0.48806255 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.61612761 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 4.53152064 |
| 3 | Birth length less than 3rd percentile (HP:0003561) | 4.46451589 |
| 4 | Reticulocytopenia (HP:0001896) | 4.45299720 |
| 5 | Colon cancer (HP:0003003) | 3.84345607 |
| 6 | Breast hypoplasia (HP:0003187) | 3.80049605 |
| 7 | Oral leukoplakia (HP:0002745) | 3.71098780 |
| 8 | Aplastic anemia (HP:0001915) | 3.64157163 |
| 9 | Degeneration of anterior horn cells (HP:0002398) | 3.58683701 |
| 10 | Abnormality of the anterior horn cell (HP:0006802) | 3.58683701 |
| 11 | Ragged-red muscle fibers (HP:0003200) | 3.52666885 |
| 12 | Selective tooth agenesis (HP:0001592) | 3.48239900 |
| 13 | Cerebral hypomyelination (HP:0006808) | 3.48189580 |
| 14 | Multiple enchondromatosis (HP:0005701) | 3.43056788 |
| 15 | Microretrognathia (HP:0000308) | 3.32454653 |
| 16 | Rough bone trabeculation (HP:0100670) | 3.31260770 |
| 17 | Patellar aplasia (HP:0006443) | 3.23725569 |
| 18 | Trismus (HP:0000211) | 3.22782122 |
| 19 | Macrocytic anemia (HP:0001972) | 3.22239165 |
| 20 | Ependymoma (HP:0002888) | 3.16999963 |
| 21 | Pallor (HP:0000980) | 3.15137363 |
| 22 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.05713387 |
| 23 | Carpal bone hypoplasia (HP:0001498) | 2.98895108 |
| 24 | 11 pairs of ribs (HP:0000878) | 2.98229705 |
| 25 | Progressive external ophthalmoplegia (HP:0000590) | 2.96677912 |
| 26 | Progressive muscle weakness (HP:0003323) | 2.90514495 |
| 27 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.77389175 |
| 28 | Type I transferrin isoform profile (HP:0003642) | 2.71409547 |
| 29 | Absent thumb (HP:0009777) | 2.65085304 |
| 30 | Abnormal number of incisors (HP:0011064) | 2.60011085 |
| 31 | Abnormality of glycolysis (HP:0004366) | 2.59021214 |
| 32 | Squamous cell carcinoma (HP:0002860) | 2.55235710 |
| 33 | Testicular atrophy (HP:0000029) | 2.55121465 |
| 34 | CNS hypomyelination (HP:0003429) | 2.55049599 |
| 35 | Neoplasm of the pancreas (HP:0002894) | 2.54852972 |
| 36 | Abnormality of reticulocytes (HP:0004312) | 2.54492343 |
| 37 | Thrombocytosis (HP:0001894) | 2.49106965 |
| 38 | Megaloblastic anemia (HP:0001889) | 2.47849648 |
| 39 | Facial cleft (HP:0002006) | 2.46221552 |
| 40 | Premature ovarian failure (HP:0008209) | 2.44663141 |
| 41 | Secondary amenorrhea (HP:0000869) | 2.44229521 |
| 42 | Overlapping toe (HP:0001845) | 2.41002596 |
| 43 | Septate vagina (HP:0001153) | 2.39740483 |
| 44 | Premature graying of hair (HP:0002216) | 2.39504004 |
| 45 | Medulloblastoma (HP:0002885) | 2.38884995 |
| 46 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.35390063 |
| 47 | Cholecystitis (HP:0001082) | 2.32972222 |
| 48 | Abnormal gallbladder physiology (HP:0012438) | 2.32972222 |
| 49 | Pelvic girdle muscle weakness (HP:0003749) | 2.31114722 |
| 50 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.30119212 |
| 51 | Cellular immunodeficiency (HP:0005374) | 2.29779940 |
| 52 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.25847533 |
| 53 | Abnormality of the calcaneus (HP:0008364) | 2.25836419 |
| 54 | Reduced antithrombin III activity (HP:0001976) | 2.23753947 |
| 55 | Myelodysplasia (HP:0002863) | 2.23106655 |
| 56 | Rhabdomyosarcoma (HP:0002859) | 2.22745857 |
| 57 | Glossoptosis (HP:0000162) | 2.21732747 |
| 58 | Cleft eyelid (HP:0000625) | 2.21654123 |
| 59 | Increased serum pyruvate (HP:0003542) | 2.21533629 |
| 60 | Impulsivity (HP:0100710) | 2.20832626 |
| 61 | Atresia of the external auditory canal (HP:0000413) | 2.19487961 |
| 62 | Abnormal protein glycosylation (HP:0012346) | 2.18324878 |
| 63 | Abnormal glycosylation (HP:0012345) | 2.18324878 |
| 64 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.18324878 |
| 65 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.18324878 |
| 66 | Hypergonadotropic hypogonadism (HP:0000815) | 2.17845475 |
| 67 | Missing ribs (HP:0000921) | 2.16101351 |
| 68 | Microvesicular hepatic steatosis (HP:0001414) | 2.13302332 |
| 69 | Pancytopenia (HP:0001876) | 2.12964975 |
| 70 | Abnormal trabecular bone morphology (HP:0100671) | 2.11990913 |
| 71 | Abnormality of the umbilical cord (HP:0010881) | 2.09795129 |
| 72 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.08388024 |
| 73 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.07020458 |
| 74 | Meckel diverticulum (HP:0002245) | 2.06365140 |
| 75 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.05843330 |
| 76 | Horseshoe kidney (HP:0000085) | 2.05191154 |
| 77 | Hypoplasia of the pons (HP:0012110) | 2.03342389 |
| 78 | Abnormal umbilical cord blood vessels (HP:0011403) | 2.03075684 |
| 79 | Single umbilical artery (HP:0001195) | 2.03075684 |
| 80 | Abnormality of the fetal cardiovascular system (HP:0010948) | 2.03075684 |
| 81 | Abnormality of the preputium (HP:0100587) | 2.03004985 |
| 82 | Truncus arteriosus (HP:0001660) | 2.02916069 |
| 83 | Hyperacusis (HP:0010780) | 2.02665758 |
| 84 | Proximal placement of thumb (HP:0009623) | 2.01985568 |
| 85 | Postnatal microcephaly (HP:0005484) | 1.99809441 |
| 86 | Homocystinuria (HP:0002156) | 1.99648828 |
| 87 | Abnormality of homocysteine metabolism (HP:0010919) | 1.99648828 |
| 88 | Chromsome breakage (HP:0040012) | 1.99461368 |
| 89 | Basal cell carcinoma (HP:0002671) | 1.98671808 |
| 90 | Increased nuchal translucency (HP:0010880) | 1.98247786 |
| 91 | Abnormality of the musculature of the pelvis (HP:0001469) | 1.98209910 |
| 92 | Abnormality of the hip-girdle musculature (HP:0001445) | 1.98209910 |
| 93 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.97452615 |
| 94 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.97452615 |
| 95 | Broad distal phalanx of finger (HP:0009836) | 1.97061986 |
| 96 | Abnormality of the ileum (HP:0001549) | 1.96965767 |
| 97 | Optic nerve coloboma (HP:0000588) | 1.96289417 |
| 98 | Abnormality of cochlea (HP:0000375) | 1.95369656 |
| 99 | Absent radius (HP:0003974) | 1.93731333 |
| 100 | Intestinal fistula (HP:0100819) | 1.93448588 |
| 101 | Abnormality of the astrocytes (HP:0100707) | 1.91716698 |
| 102 | Astrocytoma (HP:0009592) | 1.91716698 |
| 103 | Shoulder girdle muscle weakness (HP:0003547) | 1.91595506 |
| 104 | Poor head control (HP:0002421) | 1.91195709 |
| 105 | Personality changes (HP:0000751) | 1.90894532 |
| 106 | Sparse lateral eyebrow (HP:0005338) | 1.89234349 |
| 107 | Slender long bone (HP:0003100) | 1.89076750 |
| 108 | Urethral obstruction (HP:0000796) | 1.88271226 |
| 109 | Acute encephalopathy (HP:0006846) | 1.87627459 |
| 110 | Increased intramyocellular lipid droplets (HP:0012240) | 1.85449614 |
| 111 | Ectopic kidney (HP:0000086) | 1.84970587 |
| 112 | Duplicated collecting system (HP:0000081) | 1.84674617 |
| 113 | Tracheoesophageal fistula (HP:0002575) | 1.84577787 |
| 114 | Glioma (HP:0009733) | 1.84486507 |
| 115 | Nonimmune hydrops fetalis (HP:0001790) | 1.83997575 |
| 116 | Bone marrow hypocellularity (HP:0005528) | 1.83611658 |
| 117 | Ureteral duplication (HP:0000073) | 1.83298332 |
| 118 | Exercise intolerance (HP:0003546) | 1.83181949 |
| 119 | Abnormality of the carotid arteries (HP:0005344) | 1.83039497 |
| 120 | Vaginal fistula (HP:0004320) | 1.82679144 |
| 121 | Short thumb (HP:0009778) | 1.82433582 |
| 122 | Choanal atresia (HP:0000453) | 1.82225085 |
| 123 | Respiratory difficulties (HP:0002880) | 1.82119758 |
| 124 | Deviation of the thumb (HP:0009603) | 1.81740593 |
| 125 | Spastic diplegia (HP:0001264) | 1.80749598 |
| 126 | Small intestinal stenosis (HP:0012848) | 1.80263060 |
| 127 | Duodenal stenosis (HP:0100867) | 1.80263060 |
| 128 | Increased CSF lactate (HP:0002490) | 1.78599686 |
| 129 | Prominent nose (HP:0000448) | 1.78239427 |
| 130 | Increased serum lactate (HP:0002151) | 1.77820973 |
| 131 | Absent forearm bone (HP:0003953) | 1.77790443 |
| 132 | Aplasia involving forearm bones (HP:0009822) | 1.77790443 |
| 133 | Hyperglycinemia (HP:0002154) | 1.77776261 |
| 134 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.77607866 |
| 135 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.77168688 |
| 136 | Prominent metopic ridge (HP:0005487) | 1.76403745 |
| 137 | Calcaneovalgus deformity (HP:0001848) | 1.76269931 |
| 138 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.75500917 |
| 139 | Poikiloderma (HP:0001029) | 1.75134184 |
| 140 | Short middle phalanx of the 5th finger (HP:0004220) | 1.74318410 |
| 141 | Neoplasm of striated muscle (HP:0009728) | 1.74093579 |
| 142 | Cafe-au-lait spot (HP:0000957) | 1.73034543 |
| 143 | Agnosia (HP:0010524) | 1.72672995 |
| 144 | Impaired proprioception (HP:0010831) | 1.72176741 |
| 145 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.72047454 |
| 146 | Sloping forehead (HP:0000340) | 1.71688730 |
| 147 | Sparse eyelashes (HP:0000653) | 1.71661064 |
| 148 | Abnormality of chromosome stability (HP:0003220) | 1.71654605 |
| 149 | Adenoma sebaceum (HP:0009720) | 1.71545664 |
| 150 | Angiofibromas (HP:0010615) | 1.71545664 |
| 151 | Rectovaginal fistula (HP:0000143) | 1.71533142 |
| 152 | Rectal fistula (HP:0100590) | 1.71533142 |
| 153 | Entropion (HP:0000621) | 1.71421213 |
| 154 | Acute necrotizing encephalopathy (HP:0006965) | 1.70871523 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 5.09824313 |
| 2 | WEE1 | 3.88742064 |
| 3 | SMG1 | 3.61349020 |
| 4 | CDC7 | 3.52570508 |
| 5 | EIF2AK1 | 2.94894016 |
| 6 | VRK2 | 2.91650711 |
| 7 | NME2 | 2.89198650 |
| 8 | NEK2 | 2.68238287 |
| 9 | STK16 | 2.48558718 |
| 10 | IRAK3 | 2.38147182 |
| 11 | TLK1 | 2.21824266 |
| 12 | TSSK6 | 2.16804247 |
| 13 | ICK | 2.11460919 |
| 14 | TESK2 | 2.10008893 |
| 15 | NEK1 | 2.05906632 |
| 16 | VRK1 | 2.02541460 |
| 17 | EEF2K | 2.00805518 |
| 18 | SRPK1 | 1.94341451 |
| 19 | PBK | 1.89020078 |
| 20 | CDK7 | 1.82779488 |
| 21 | RPS6KA4 | 1.80506627 |
| 22 | PKN2 | 1.80271644 |
| 23 | EIF2AK3 | 1.73594409 |
| 24 | PLK1 | 1.70996086 |
| 25 | TTK | 1.69530757 |
| 26 | PASK | 1.68207985 |
| 27 | SCYL2 | 1.66701658 |
| 28 | DYRK3 | 1.63050655 |
| 29 | ATR | 1.62299595 |
| 30 | BRSK2 | 1.62082552 |
| 31 | TRIB3 | 1.61961064 |
| 32 | ACVR1B | 1.60623207 |
| 33 | MAP4K1 | 1.47432616 |
| 34 | MAP3K10 | 1.46201557 |
| 35 | EPHA2 | 1.42948521 |
| 36 | AURKB | 1.40161123 |
| 37 | PAK4 | 1.36597773 |
| 38 | MAP3K8 | 1.36424895 |
| 39 | BRSK1 | 1.35318079 |
| 40 | PDK2 | 1.35301045 |
| 41 | RPS6KB2 | 1.32854473 |
| 42 | CCNB1 | 1.31880864 |
| 43 | MAP3K11 | 1.27661221 |
| 44 | TGFBR1 | 1.26677122 |
| 45 | MKNK1 | 1.25464833 |
| 46 | PLK3 | 1.24799940 |
| 47 | AURKA | 1.24166734 |
| 48 | PLK4 | 1.22559524 |
| 49 | CHEK2 | 1.15836894 |
| 50 | PIM2 | 1.15696200 |
| 51 | CDK4 | 1.15218118 |
| 52 | PRPF4B | 1.02968461 |
| 53 | TAF1 | 1.02540030 |
| 54 | BCKDK | 1.01572856 |
| 55 | FLT3 | 0.99918061 |
| 56 | CHEK1 | 0.98867518 |
| 57 | KDR | 0.95344622 |
| 58 | TESK1 | 0.95336557 |
| 59 | LRRK2 | 0.93333008 |
| 60 | CDK12 | 0.93141389 |
| 61 | STK10 | 0.92908786 |
| 62 | ERN1 | 0.91868529 |
| 63 | MAP2K3 | 0.90203461 |
| 64 | TAOK2 | 0.90055883 |
| 65 | ALK | 0.89460093 |
| 66 | MAP3K3 | 0.87265883 |
| 67 | MST1R | 0.84841787 |
| 68 | CDK2 | 0.78855086 |
| 69 | ARAF | 0.74834832 |
| 70 | BLK | 0.74480537 |
| 71 | CLK1 | 0.73365354 |
| 72 | MKNK2 | 0.72703445 |
| 73 | CDK9 | 0.71224342 |
| 74 | PAK1 | 0.70895495 |
| 75 | CSNK2A2 | 0.69891613 |
| 76 | MELK | 0.67781207 |
| 77 | ZAP70 | 0.66151951 |
| 78 | PRKCI | 0.63787486 |
| 79 | BRD4 | 0.63719676 |
| 80 | MTOR | 0.63680093 |
| 81 | ATM | 0.63437602 |
| 82 | LATS2 | 0.59939940 |
| 83 | CDK8 | 0.59110666 |
| 84 | CSNK2A1 | 0.58973224 |
| 85 | BRAF | 0.58639308 |
| 86 | PIM1 | 0.58428582 |
| 87 | SIK1 | 0.58327933 |
| 88 | GRK6 | 0.57140243 |
| 89 | TTN | 0.55351059 |
| 90 | AKT2 | 0.54716528 |
| 91 | IRAK2 | 0.53799567 |
| 92 | BTK | 0.52394630 |
| 93 | CDK1 | 0.47577444 |
| 94 | NME1 | 0.47570574 |
| 95 | ILK | 0.42925961 |
| 96 | DAPK1 | 0.42139749 |
| 97 | PAK2 | 0.40520375 |
| 98 | BMX | 0.40413783 |
| 99 | ZAK | 0.39579744 |
| 100 | FGFR4 | 0.38164906 |
| 101 | CSNK1E | 0.38053563 |
| 102 | MAPK11 | 0.37603097 |
| 103 | RPS6KA5 | 0.36592278 |
| 104 | CDK6 | 0.36373282 |
| 105 | MAPKAPK3 | 0.36246624 |
| 106 | CAMK1D | 0.36013820 |
| 107 | MAP2K2 | 0.35912097 |
| 108 | MST4 | 0.33262908 |
| 109 | TAOK1 | 0.30928219 |
| 110 | DAPK3 | 0.30202815 |
| 111 | PRKDC | 0.28187991 |
| 112 | STK4 | 0.27924822 |
| 113 | ABL2 | 0.27816485 |
| 114 | RPS6KA1 | 0.24438645 |
| 115 | MAPK9 | 0.24435550 |
| 116 | LIMK1 | 0.24382303 |
| 117 | CSF1R | 0.24342595 |
| 118 | RAF1 | 0.23216516 |
| 119 | DYRK2 | 0.23078438 |
| 120 | EIF2AK2 | 0.21559484 |
| 121 | JAK3 | 0.21084038 |
| 122 | MAP3K5 | 0.20689903 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 5.02915012 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 3.91719650 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.73911542 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 3.60866635 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.45546363 |
| 6 | Spliceosome_Homo sapiens_hsa03040 | 3.43055144 |
| 7 | Proteasome_Homo sapiens_hsa03050 | 3.29051867 |
| 8 | RNA transport_Homo sapiens_hsa03013 | 3.15563873 |
| 9 | Base excision repair_Homo sapiens_hsa03410 | 3.10662970 |
| 10 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.90529858 |
| 11 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.73793662 |
| 12 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.64535622 |
| 13 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.54745477 |
| 14 | Homologous recombination_Homo sapiens_hsa03440 | 2.53998652 |
| 15 | Cell cycle_Homo sapiens_hsa04110 | 2.35498782 |
| 16 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.68347366 |
| 17 | RNA degradation_Homo sapiens_hsa03018 | 1.63941819 |
| 18 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.62551368 |
| 19 | Sulfur relay system_Homo sapiens_hsa04122 | 1.56125283 |
| 20 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.51223281 |
| 21 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.44714094 |
| 22 | Purine metabolism_Homo sapiens_hsa00230 | 1.36079790 |
| 23 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.35689982 |
| 24 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.33775771 |
| 25 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.33083292 |
| 26 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.32312797 |
| 27 | Basal transcription factors_Homo sapiens_hsa03022 | 1.31451289 |
| 28 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.23656686 |
| 29 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.19960329 |
| 30 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.18010673 |
| 31 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.17340046 |
| 32 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.12895347 |
| 33 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.11949460 |
| 34 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.04768838 |
| 35 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.04330763 |
| 36 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.01041470 |
| 37 | Carbon metabolism_Homo sapiens_hsa01200 | 0.86031231 |
| 38 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.85861106 |
| 39 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.83291656 |
| 40 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.81165660 |
| 41 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.80110770 |
| 42 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.79106389 |
| 43 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.79065462 |
| 44 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.77353874 |
| 45 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.77352087 |
| 46 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.73803660 |
| 47 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.71751612 |
| 48 | Parkinsons disease_Homo sapiens_hsa05012 | 0.71671875 |
| 49 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.71542907 |
| 50 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.69860717 |
| 51 | HTLV-I infection_Homo sapiens_hsa05166 | 0.68759923 |
| 52 | Thyroid cancer_Homo sapiens_hsa05216 | 0.66111888 |
| 53 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.65871547 |
| 54 | Galactose metabolism_Homo sapiens_hsa00052 | 0.62275696 |
| 55 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.60770341 |
| 56 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.56048700 |
| 57 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.55916094 |
| 58 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.52489309 |
| 59 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.51966257 |
| 60 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.50391814 |
| 61 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.48552126 |
| 62 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.48200645 |
| 63 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.47942066 |
| 64 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.47551555 |
| 65 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.45939434 |
| 66 | Bladder cancer_Homo sapiens_hsa05219 | 0.45745993 |
| 67 | Legionellosis_Homo sapiens_hsa05134 | 0.45429905 |
| 68 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.42780779 |
| 69 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.40262857 |
| 70 | Protein export_Homo sapiens_hsa03060 | 0.39780092 |
| 71 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.39249277 |
| 72 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.38659313 |
| 73 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.37515339 |
| 74 | Apoptosis_Homo sapiens_hsa04210 | 0.37007987 |
| 75 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.36111174 |
| 76 | Other glycan degradation_Homo sapiens_hsa00511 | 0.34400514 |
| 77 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.33369827 |
| 78 | Shigellosis_Homo sapiens_hsa05131 | 0.31552938 |
| 79 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.30568483 |
| 80 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.30499076 |
| 81 | Colorectal cancer_Homo sapiens_hsa05210 | 0.29491130 |
| 82 | Hepatitis B_Homo sapiens_hsa05161 | 0.28874477 |
| 83 | Prostate cancer_Homo sapiens_hsa05215 | 0.28318901 |
| 84 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.27869249 |
| 85 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.27017805 |
| 86 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.25729709 |
| 87 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.24896310 |
| 88 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.24591150 |
| 89 | Metabolic pathways_Homo sapiens_hsa01100 | 0.24412163 |
| 90 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.24161699 |
| 91 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.23991235 |
| 92 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.23664081 |
| 93 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.23482707 |
| 94 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.23336709 |
| 95 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.22769479 |
| 96 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.22541253 |
| 97 | Alzheimers disease_Homo sapiens_hsa05010 | 0.21763231 |
| 98 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.21033831 |
| 99 | Alcoholism_Homo sapiens_hsa05034 | 0.19927919 |
| 100 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.19780152 |
| 101 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.18366070 |
| 102 | Endometrial cancer_Homo sapiens_hsa05213 | 0.17593027 |
| 103 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.15336376 |
| 104 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.13622858 |
| 105 | Lysine degradation_Homo sapiens_hsa00310 | 0.11761571 |
| 106 | Measles_Homo sapiens_hsa05162 | 0.08691753 |
| 107 | Huntingtons disease_Homo sapiens_hsa05016 | 0.07765940 |
| 108 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.07577119 |
| 109 | Pathways in cancer_Homo sapiens_hsa05200 | 0.06807157 |
| 110 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.06310562 |
| 111 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.04961631 |
| 112 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.04926492 |
| 113 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.04302296 |
| 114 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.03803345 |
| 115 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.03765771 |
| 116 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.02946659 |
| 117 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.01859591 |
| 118 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.01144482 |

