WDR41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of meiosis I (GO:0060631)4.47980472
2synapsis (GO:0007129)4.23640129
3DNA double-strand break processing (GO:0000729)4.09999252
4protein localization to kinetochore (GO:0034501)4.05190187
5CENP-A containing nucleosome assembly (GO:0034080)3.99181452
6piRNA metabolic process (GO:0034587)3.96476480
7positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.96221762
8chromatin remodeling at centromere (GO:0031055)3.89577691
9metaphase plate congression (GO:0051310)3.88791612
10mitotic metaphase plate congression (GO:0007080)3.80878858
11attachment of spindle microtubules to kinetochore (GO:0008608)3.72064257
12proteasome assembly (GO:0043248)3.64311136
13resolution of meiotic recombination intermediates (GO:0000712)3.50063987
14protein localization to chromosome, centromeric region (GO:0071459)3.47258249
15histone exchange (GO:0043486)3.44675463
16macroautophagy (GO:0016236)3.43583905
17establishment of chromosome localization (GO:0051303)3.34969804
18meiotic chromosome segregation (GO:0045132)3.19486378
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.18681228
20nerve growth factor signaling pathway (GO:0038180)3.17783654
21cellular potassium ion homeostasis (GO:0030007)3.16107043
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.12023913
23positive regulation by organism of defense response of other organism involved in symbiotic interact3.12023913
24modulation by symbiont of host immune response (GO:0052553)3.12023913
25positive regulation by symbiont of host defense response (GO:0052509)3.12023913
26modulation by symbiont of host defense response (GO:0052031)3.12023913
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.12023913
28spindle checkpoint (GO:0031577)3.11605055
29cullin deneddylation (GO:0010388)3.06035765
30positive regulation of mitotic sister chromatid separation (GO:1901970)3.05327908
31positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.05327908
32positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.05327908
33replication fork processing (GO:0031297)3.00012820
34mating behavior (GO:0007617)2.99513684
35kinetochore organization (GO:0051383)2.98491581
36microtubule depolymerization (GO:0007019)2.97492747
37centriole replication (GO:0007099)2.97014403
38DNA replication-independent nucleosome organization (GO:0034724)2.95882315
39DNA replication-independent nucleosome assembly (GO:0006336)2.95882315
40activation of protein kinase A activity (GO:0034199)2.95673705
41intraciliary transport (GO:0042073)2.91734300
42mitotic spindle checkpoint (GO:0071174)2.89145937
43synaptic vesicle maturation (GO:0016188)2.88227698
44DNA replication checkpoint (GO:0000076)2.87856462
45regulation of centrosome cycle (GO:0046605)2.86464124
46mitotic sister chromatid cohesion (GO:0007064)2.85580740
47chromosome organization involved in meiosis (GO:0070192)2.83298886
48meiotic cell cycle (GO:0051321)2.82976785
49synaptic vesicle exocytosis (GO:0016079)2.82190850
50L-fucose catabolic process (GO:0042355)2.81843224
51fucose catabolic process (GO:0019317)2.81843224
52L-fucose metabolic process (GO:0042354)2.81843224
53negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.81183356
54microtubule anchoring (GO:0034453)2.80597535
55cilium morphogenesis (GO:0060271)2.80204646
56regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.78870325
57regulation of mitotic metaphase/anaphase transition (GO:0030071)2.78870325
58regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.78845356
59regulation of mitotic spindle checkpoint (GO:1903504)2.78845356
60DNA replication-dependent nucleosome assembly (GO:0006335)2.78316724
61DNA replication-dependent nucleosome organization (GO:0034723)2.78316724
62sister chromatid cohesion (GO:0007062)2.78174036
63response to pheromone (GO:0019236)2.76925821
64regulation of DNA endoreduplication (GO:0032875)2.76780820
65glucosamine-containing compound catabolic process (GO:1901072)2.76626339
66protein K6-linked ubiquitination (GO:0085020)2.76355518
67negative regulation of DNA-dependent DNA replication (GO:2000104)2.75716524
68RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.75680202
69somatic hypermutation of immunoglobulin genes (GO:0016446)2.75274358
70somatic diversification of immune receptors via somatic mutation (GO:0002566)2.75274358
71protein neddylation (GO:0045116)2.74522677
72potassium ion import (GO:0010107)2.73678868
73kinetochore assembly (GO:0051382)2.72164238
74histone H2A acetylation (GO:0043968)2.71144307
75DNA methylation involved in gamete generation (GO:0043046)2.70480687
76regulation of centriole replication (GO:0046599)2.70262132
77C4-dicarboxylate transport (GO:0015740)2.69300249
78male meiosis I (GO:0007141)2.69298567
79L-amino acid import (GO:0043092)2.68880316
80alanine transport (GO:0032328)2.68716214
81regulation of mitotic sister chromatid separation (GO:0010965)2.67867038
82regulation of mitotic sister chromatid segregation (GO:0033047)2.67867038
83regulation of sister chromatid segregation (GO:0033045)2.67867038
84epithelial cilium movement (GO:0003351)2.67756707
85sodium ion export (GO:0071436)2.67392993
86male meiosis (GO:0007140)2.67281110
87postreplication repair (GO:0006301)2.66379965
88ether lipid metabolic process (GO:0046485)2.66002045
89negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.63965330
90negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.63965330
91negative regulation of mitotic sister chromatid segregation (GO:0033048)2.63965330
92negative regulation of mitotic sister chromatid separation (GO:2000816)2.63965330
93negative regulation of sister chromatid segregation (GO:0033046)2.63965330
94protein prenylation (GO:0018342)2.63388923
95prenylation (GO:0097354)2.63388923
96regulation of centrosome duplication (GO:0010824)2.62841892
97non-recombinational repair (GO:0000726)2.62671854
98double-strand break repair via nonhomologous end joining (GO:0006303)2.62671854
99cerebellar Purkinje cell layer development (GO:0021680)2.62494619
100nuclear pore organization (GO:0006999)2.61853423
101protein K11-linked ubiquitination (GO:0070979)2.60658157
102DNA ligation (GO:0006266)2.60452064
103locomotory exploration behavior (GO:0035641)2.60215780
104spindle assembly checkpoint (GO:0071173)2.60200087
105mitotic spindle assembly checkpoint (GO:0007094)2.59966718
106suckling behavior (GO:0001967)2.59113708
107regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.58948501
108protein localization to chromosome (GO:0034502)2.58762319
109negative regulation of chromosome segregation (GO:0051985)2.58167760
110antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.58092623
111alpha-linolenic acid metabolic process (GO:0036109)2.56553689
112organelle disassembly (GO:1903008)2.56396652
113negative regulation of microtubule polymerization (GO:0031115)2.56127818
114regulation of synaptic vesicle exocytosis (GO:2000300)2.55984695
115protein deneddylation (GO:0000338)2.55953297
116regulation of synaptic vesicle transport (GO:1902803)2.55898079
117monoubiquitinated protein deubiquitination (GO:0035520)2.55585667
118ribonucleoprotein complex disassembly (GO:0032988)2.55566854
119response to methylmercury (GO:0051597)2.55452353
120response to X-ray (GO:0010165)2.55071364
121mitotic spindle organization (GO:0007052)2.53827571
122gene silencing by RNA (GO:0031047)2.53753848
123meiotic cell cycle process (GO:1903046)2.53723782
124protein maturation by protein folding (GO:0022417)2.53226455
125positive regulation of vesicle fusion (GO:0031340)2.51967425
126DNA catabolic process, exonucleolytic (GO:0000738)2.51267486
127organelle transport along microtubule (GO:0072384)2.50938304
128microtubule polymerization or depolymerization (GO:0031109)2.50110137
129retinal cone cell development (GO:0046549)2.49902557
130negative regulation of neurotransmitter transport (GO:0051589)2.48462323
131creatine metabolic process (GO:0006600)2.48259255
132anterograde synaptic vesicle transport (GO:0048490)2.48103566
133vesicle transport along microtubule (GO:0047496)2.46923484
134cilium assembly (GO:0042384)2.46802695
135short-chain fatty acid metabolic process (GO:0046459)2.46540081
136regulation of chromosome segregation (GO:0051983)2.45972714
137proline transport (GO:0015824)2.44831224
138recombinational repair (GO:0000725)2.44443382
139cilium organization (GO:0044782)2.44313556
140double-strand break repair via homologous recombination (GO:0000724)2.42201568
141positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.40417224
142fucose metabolic process (GO:0006004)2.40214484
143regulation of cilium movement (GO:0003352)2.40023973
144negative regulation of meiosis (GO:0045835)2.39212345
145macrophage activation involved in immune response (GO:0002281)2.38829854
146regulation of amyloid precursor protein catabolic process (GO:1902991)2.38759083
147regulation of synapse structural plasticity (GO:0051823)2.38697065
148positive regulation of glycolytic process (GO:0045821)2.32548951
149positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.30698353
150neurotransmitter secretion (GO:0007269)2.30508322
151protein localization to endosome (GO:0036010)2.30318647
152localization within membrane (GO:0051668)2.29483883
153fucosylation (GO:0036065)2.27437525
154positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.26076931
155potassium ion homeostasis (GO:0055075)2.26028584
156heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.25542450
157regulation of vesicle fusion (GO:0031338)2.24864525
158establishment of protein localization to Golgi (GO:0072600)2.22644143
159insulin secretion (GO:0030073)2.21893518
160amino acid import (GO:0043090)2.21423321
161negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.21388267
162membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.21386852
163retrograde transport, vesicle recycling within Golgi (GO:0000301)2.20958323
164cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.20573495
165cellular response to glucagon stimulus (GO:0071377)2.19347702
166long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.18910134
167response to nerve growth factor (GO:1990089)2.18308083
168cellular response to nerve growth factor stimulus (GO:1990090)2.18308083
169negative regulation of cytosolic calcium ion concentration (GO:0051481)2.17094534
170regulation of ARF protein signal transduction (GO:0032012)2.16798761
171regulation of calcium ion transmembrane transport (GO:1903169)2.15860034
172regulation of calcium ion transmembrane transporter activity (GO:1901019)2.15860034
173neuromuscular process controlling posture (GO:0050884)2.15531128
174lipoprotein transport (GO:0042953)2.15521738
175protein targeting to Golgi (GO:0000042)2.15470396
176regulation of short-term neuronal synaptic plasticity (GO:0048172)2.15364131
177regulation of ARF GTPase activity (GO:0032312)2.14673629
178heparan sulfate proteoglycan metabolic process (GO:0030201)2.13532722
179microglial cell activation (GO:0001774)2.13486350
180apoptotic cell clearance (GO:0043277)2.13443133
181regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.13418793
182ATP hydrolysis coupled proton transport (GO:0015991)2.13363508
183energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.13363508
184glutamate secretion (GO:0014047)2.12770576
185L-serine transport (GO:0015825)2.11428135
186phospholipid translocation (GO:0045332)2.10923828
187lipid translocation (GO:0034204)2.10923828
188regulation of fatty acid beta-oxidation (GO:0031998)2.10840872
189COPI coating of Golgi vesicle (GO:0048205)2.10785965
190Golgi transport vesicle coating (GO:0048200)2.10785965
191synaptic vesicle endocytosis (GO:0048488)2.10326571
192negative regulation of response to reactive oxygen species (GO:1901032)2.10159152
193peptidyl-tyrosine autophosphorylation (GO:0038083)2.10117026
194establishment of mitochondrion localization (GO:0051654)2.07375329
195detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.07162994
196detection of temperature stimulus involved in sensory perception (GO:0050961)2.07162994
197positive regulation of glycogen biosynthetic process (GO:0045725)2.06769887
198fatty-acyl-CoA biosynthetic process (GO:0046949)2.06745336
199axon cargo transport (GO:0008088)2.04143645
200regulation of voltage-gated calcium channel activity (GO:1901385)2.03844466

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.30444498
2POU3F2_20337985_ChIP-ChIP_501MEL_Human2.85409380
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.66675593
4EWS_26573619_Chip-Seq_HEK293_Human2.66602204
5* FUS_26573619_Chip-Seq_HEK293_Human2.60561562
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.49315122
7TAF15_26573619_Chip-Seq_HEK293_Human2.34520735
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.34410092
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.34077716
10EZH2_22144423_ChIP-Seq_EOC_Human2.20283637
11ELK1_19687146_ChIP-ChIP_HELA_Human2.18691425
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.15010973
13VDR_22108803_ChIP-Seq_LS180_Human2.11320460
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08898412
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.03333000
16P300_19829295_ChIP-Seq_ESCs_Human2.03317248
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.03121547
18DROSHA_22980978_ChIP-Seq_HELA_Human2.01843787
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.01520182
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.01233182
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.94989485
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.93733896
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.90494395
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90301529
25E2F7_22180533_ChIP-Seq_HELA_Human1.90007880
26GATA1_22025678_ChIP-Seq_K562_Human1.88094236
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.82440233
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81446388
29RARB_27405468_Chip-Seq_BRAIN_Mouse1.81400786
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80945988
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78845037
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77357004
33GBX2_23144817_ChIP-Seq_PC3_Human1.73835421
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69128852
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.68721136
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67920169
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66620969
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64893260
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62169305
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61177529
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.60885943
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60405121
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57130681
44REST_21632747_ChIP-Seq_MESCs_Mouse1.56567182
45SPI1_23127762_ChIP-Seq_K562_Human1.55801985
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55308506
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54898636
48* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54499952
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52946113
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50511870
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50451096
52* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50419378
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46757651
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.45178899
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.45046957
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43291436
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40962756
58AR_21572438_ChIP-Seq_LNCaP_Human1.40735404
59SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40063841
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39654516
61ER_23166858_ChIP-Seq_MCF-7_Human1.38842569
62AR_21909140_ChIP-Seq_LNCAP_Human1.36780983
63REST_18959480_ChIP-ChIP_MESCs_Mouse1.36120686
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35884930
65RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34898844
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33886051
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33812675
68CBP_20019798_ChIP-Seq_JUKART_Human1.33812675
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.32950882
70JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32579737
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.32542044
72JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32348051
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.31986342
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31008569
75GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29838889
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29730326
77WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29700157
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29580047
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28799095
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.28356083
81NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28186656
82SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28171238
83TCF4_23295773_ChIP-Seq_U87_Human1.27454233
84CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27248061
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27176532
86SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26744019
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26598558
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.25643794
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25193925
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24507581
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24384774
92* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24260644
93CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24093386
94DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24060906
95MYC_18940864_ChIP-ChIP_HL60_Human1.23538042
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23269769
97VDR_23849224_ChIP-Seq_CD4+_Human1.22542580
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22363120
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20921578
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20582017
101EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19440602
102RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19440602
103AR_25329375_ChIP-Seq_VCAP_Human1.19106179
104CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18759695
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.18551241
106THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16727266
107ESR2_21235772_ChIP-Seq_MCF-7_Human1.16635356
108GATA2_21666600_ChIP-Seq_HMVEC_Human1.14774622
109GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14727906
110IRF1_19129219_ChIP-ChIP_H3396_Human1.14301548
111RXR_22158963_ChIP-Seq_LIVER_Mouse1.14024976
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13887411
113FOXA2_19822575_ChIP-Seq_HepG2_Human1.13563621
114MYB_21317192_ChIP-Seq_ERMYB_Mouse1.13516327
115HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13166961
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12683827
117TP53_16413492_ChIP-PET_HCT116_Human1.11994604
118EZH2_27294783_Chip-Seq_ESCs_Mouse1.11544012
119* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11484833
120RUNX2_22187159_ChIP-Seq_PCA_Human1.10923811
121E2F1_18555785_Chip-Seq_ESCs_Mouse1.10755482
122TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10325062
123* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10318712
124MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10213709
125* TET1_21490601_ChIP-Seq_MESCs_Mouse1.10187723
126PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.09499286
127* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09388776
128TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09310098
129ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.09216097
130GATA1_19941827_ChIP-Seq_MEL_Mouse1.08981954
131IGF1R_20145208_ChIP-Seq_DFB_Human1.08866101
132CRX_20693478_ChIP-Seq_RETINA_Mouse1.08736034
133P53_22387025_ChIP-Seq_ESCs_Mouse1.07989031
134NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07814439
135NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07814439
136KDM2B_26808549_Chip-Seq_K562_Human1.07724734
137TCF4_22108803_ChIP-Seq_LS180_Human1.07531329
138* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07514017
139RNF2_27304074_Chip-Seq_ESCs_Mouse1.06973323
140NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06962737
141LXR_22292898_ChIP-Seq_THP-1_Human1.06605587
142TP63_19390658_ChIP-ChIP_HaCaT_Human1.06578817
143* RNF2_27304074_Chip-Seq_NSC_Mouse1.06404933
144TAL1_26923725_Chip-Seq_HPCs_Mouse1.06052168
145JUN_21703547_ChIP-Seq_K562_Human1.05474699
146NANOG_19829295_ChIP-Seq_ESCs_Human1.05321754
147SOX2_19829295_ChIP-Seq_ESCs_Human1.05321754
148NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05223039
149SOX2_21211035_ChIP-Seq_LN229_Gbm1.04830112
150PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04545885
151LXR_22158963_ChIP-Seq_LIVER_Mouse1.04183831
152SOX9_26525672_Chip-Seq_HEART_Mouse1.03049577
153VDR_24787735_ChIP-Seq_THP-1_Human1.02944224
154WT1_19549856_ChIP-ChIP_CCG9911_Human1.02416663
155KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01527603
156TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01001281
157POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01001281
158YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00779020
159OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00775327
160ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00727067
161CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00603507
162BRD4_25478319_ChIP-Seq_HGPS_Human1.00340574
163SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99778189
164SMAD4_21799915_ChIP-Seq_A2780_Human0.99463117
165BCAT_22108803_ChIP-Seq_LS180_Human0.97762237
166CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97436327
167GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97332951
168EP300_21415370_ChIP-Seq_HL-1_Mouse0.97110341
169KDM2B_26808549_Chip-Seq_DND41_Human0.96898383
170NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96635607
171GATA1_19941826_ChIP-Seq_K562_Human0.95228417
172PIAS1_25552417_ChIP-Seq_VCAP_Human0.94912284
173KDM2B_26808549_Chip-Seq_JURKAT_Human0.94809531
174TBX20_22080862_ChIP-Seq_HEART_Mouse0.94756910
175TBX20_22328084_ChIP-Seq_HEART_Mouse0.94756910
176IRF8_27001747_Chip-Seq_BMDM_Mouse0.94189260
177VDR_24763502_ChIP-Seq_THP-1_Human0.93503486
178SMAD_19615063_ChIP-ChIP_OVARY_Human0.92868450
179OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91193196
180P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89726034
181CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.88869967
182* STAT3_23295773_ChIP-Seq_U87_Human0.88514993
183* AR_19668381_ChIP-Seq_PC3_Human0.88500144
184ZNF274_21170338_ChIP-Seq_K562_Hela0.88140736
185YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87449409

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.15278679
2MP0008877_abnormal_DNA_methylation2.90022494
3MP0000569_abnormal_digit_pigmentation2.85519822
4MP0008057_abnormal_DNA_replication2.82518520
5MP0002909_abnormal_adrenal_gland2.73095756
6MP0008058_abnormal_DNA_repair2.63868631
7MP0004859_abnormal_synaptic_plasticity2.57144941
8MP0009780_abnormal_chondrocyte_physiolo2.50601569
9MP0004130_abnormal_muscle_cell2.46660748
10MP0010094_abnormal_chromosome_stability2.45249310
11MP0010234_abnormal_vibrissa_follicle2.39966883
12MP0003183_abnormal_peptide_metabolism2.33429543
13MP0000747_muscle_weakness2.28654583
14MP0003718_maternal_effect2.27940038
15MP0003172_abnormal_lysosome_physiology2.27059253
16MP0006292_abnormal_olfactory_placode2.15452366
17MP0003283_abnormal_digestive_organ2.13405758
18MP0000751_myopathy2.13190480
19MP0008789_abnormal_olfactory_epithelium2.12108352
20MP0001984_abnormal_olfaction2.01612932
21MP0003635_abnormal_synaptic_transmissio1.90170493
22MP0002822_catalepsy1.88684128
23MP0000920_abnormal_myelination1.87273774
24MP0003690_abnormal_glial_cell1.79260286
25MP0001293_anophthalmia1.79260229
26MP0009697_abnormal_copulation1.78408023
27MP0002837_dystrophic_cardiac_calcinosis1.78029207
28MP0002064_seizures1.76885651
29MP0002090_abnormal_vision1.76838364
30MP0009046_muscle_twitch1.75589470
31MP0000013_abnormal_adipose_tissue1.67535979
32MP0005551_abnormal_eye_electrophysiolog1.66672415
33MP0003077_abnormal_cell_cycle1.65849156
34MP0003329_amyloid_beta_deposits1.65723803
35MP0003890_abnormal_embryonic-extraembry1.64877227
36MP0005423_abnormal_somatic_nervous1.63816298
37MP0001986_abnormal_taste_sensitivity1.60887799
38MP0004957_abnormal_blastocyst_morpholog1.60064703
39MP0006072_abnormal_retinal_apoptosis1.59930879
40MP0002272_abnormal_nervous_system1.57179059
41MP0003136_yellow_coat_color1.56970442
42MP0000604_amyloidosis1.56700365
43MP0003937_abnormal_limbs/digits/tail_de1.56226254
44MP0003300_gastrointestinal_ulcer1.55836637
45MP0008932_abnormal_embryonic_tissue1.54637473
46MP0005171_absent_coat_pigmentation1.54358512
47MP0003880_abnormal_central_pattern1.54353932
48MP0002233_abnormal_nose_morphology1.54301773
49MP0010030_abnormal_orbit_morphology1.54292597
50MP0010386_abnormal_urinary_bladder1.54241698
51MP0005499_abnormal_olfactory_system1.52772283
52MP0005394_taste/olfaction_phenotype1.52772283
53MP0004270_analgesia1.51527862
54MP0000372_irregular_coat_pigmentation1.50353261
55MP0004858_abnormal_nervous_system1.47665040
56MP0002102_abnormal_ear_morphology1.47582295
57MP0004043_abnormal_pH_regulation1.47171769
58MP0003634_abnormal_glial_cell1.47138170
59MP0003633_abnormal_nervous_system1.46824057
60MP0009840_abnormal_foam_cell1.46638290
61MP0003303_peritoneal_inflammation1.45520744
62MP0005174_abnormal_tail_pigmentation1.43968138
63MP0002938_white_spotting1.43804343
64MP0009745_abnormal_behavioral_response1.43203400
65MP0002269_muscular_atrophy1.42715025
66MP0008961_abnormal_basal_metabolism1.41966582
67MP0000427_abnormal_hair_cycle1.40466452
68MP0002229_neurodegeneration1.38072027
69MP0003950_abnormal_plasma_membrane1.36575827
70MP0009250_abnormal_appendicular_skeleto1.35680708
71MP0000749_muscle_degeneration1.35124310
72MP0003693_abnormal_embryo_hatching1.35005067
73MP0002210_abnormal_sex_determination1.32337330
74MP0004145_abnormal_muscle_electrophysio1.31116937
75MP0002063_abnormal_learning/memory/cond1.29570998
76MP0001929_abnormal_gametogenesis1.29119765
77MP0006276_abnormal_autonomic_nervous1.28502436
78MP0005187_abnormal_penis_morphology1.28398679
79MP0004185_abnormal_adipocyte_glucose1.28049980
80MP0003941_abnormal_skin_development1.26871354
81MP0005623_abnormal_meninges_morphology1.25479266
82MP0003075_altered_response_to1.24691201
83MP0004036_abnormal_muscle_relaxation1.24260563
84MP0002160_abnormal_reproductive_system1.24064686
85MP0005645_abnormal_hypothalamus_physiol1.22008760
86MP0005535_abnormal_body_temperature1.20093764
87MP0008569_lethality_at_weaning1.18975627
88MP0003755_abnormal_palate_morphology1.18524905
89MP0002282_abnormal_trachea_morphology1.18400609
90MP0003191_abnormal_cellular_cholesterol1.16767986
91MP0003646_muscle_fatigue1.15708513
92MP0000778_abnormal_nervous_system1.15055088
93MP0001177_atelectasis1.14399530
94MP0000647_abnormal_sebaceous_gland1.14352076
95MP0004142_abnormal_muscle_tone1.13595920
96MP0006054_spinal_hemorrhage1.13363091
97MP0002751_abnormal_autonomic_nervous1.12960649
98MP0003111_abnormal_nucleus_morphology1.11287263
99MP0003656_abnormal_erythrocyte_physiolo1.10463651
100MP0000631_abnormal_neuroendocrine_gland1.09871496
101MP0008007_abnormal_cellular_replicative1.09312821
102MP0000653_abnormal_sex_gland1.09073368
103MP0002733_abnormal_thermal_nociception1.08777759
104MP0002234_abnormal_pharynx_morphology1.08719671
105MP0002572_abnormal_emotion/affect_behav1.08497219
106MP0000462_abnormal_digestive_system1.07289543
107MP0003121_genomic_imprinting1.06925252
108MP0000049_abnormal_middle_ear1.06596643
109MP0004233_abnormal_muscle_weight1.06466573
110MP0005395_other_phenotype1.06199318
111MP0005083_abnormal_biliary_tract1.05682610
112MP0001968_abnormal_touch/_nociception1.05307866
113MP0003631_nervous_system_phenotype1.03195543
114MP0004215_abnormal_myocardial_fiber1.02564177
115MP0005503_abnormal_tendon_morphology1.02210681
116MP0001286_abnormal_eye_development1.01285668
117MP0001145_abnormal_male_reproductive1.01180900
118MP0001440_abnormal_grooming_behavior1.00996108
119MP0004885_abnormal_endolymph1.00976740
120MP0001879_abnormal_lymphatic_vessel1.00782460
121MP0005375_adipose_tissue_phenotype0.99992558
122MP0001270_distended_abdomen0.99495977
123MP0001501_abnormal_sleep_pattern0.99457807
124MP0001299_abnormal_eye_distance/0.99224910
125MP0005248_abnormal_Harderian_gland0.99198178
126MP0002734_abnormal_mechanical_nocicepti0.98658590
127MP0002177_abnormal_outer_ear0.98474967
128MP0001970_abnormal_pain_threshold0.98058648
129MP0002139_abnormal_hepatobiliary_system0.97246328
130MP0002084_abnormal_developmental_patter0.97099521
131MP0002078_abnormal_glucose_homeostasis0.96898709
132MP0001529_abnormal_vocalization0.96645197
133MP0004811_abnormal_neuron_physiology0.96238079
134MP0000003_abnormal_adipose_tissue0.95275328
135MP0003698_abnormal_male_reproductive0.94955302
136MP0002118_abnormal_lipid_homeostasis0.94845478
137MP0003868_abnormal_feces_composition0.94462274
138MP0010368_abnormal_lymphatic_system0.94450022
139MP0002067_abnormal_sensory_capabilities0.94099043
140MP0002736_abnormal_nociception_after0.93769384
141MP0000955_abnormal_spinal_cord0.93563228
142MP0008438_abnormal_cutaneous_collagen0.92980439
143MP0002095_abnormal_skin_pigmentation0.91783069
144MP0001324_abnormal_eye_pigmentation0.91524301
145MP0001486_abnormal_startle_reflex0.91437224
146MP0003186_abnormal_redox_activity0.91336047
147MP0008874_decreased_physiological_sensi0.91160459
148MP0005391_vision/eye_phenotype0.91023004
149MP0005666_abnormal_adipose_tissue0.90343116
150MP0000516_abnormal_urinary_system0.89766038
151MP0005367_renal/urinary_system_phenotyp0.89766038
152MP0004147_increased_porphyrin_level0.89126782
153MP0005386_behavior/neurological_phenoty0.88255794
154MP0004924_abnormal_behavior0.88255794
155MP0004087_abnormal_muscle_fiber0.87683039
156MP0000358_abnormal_cell_content/0.87386518
157MP0003385_abnormal_body_wall0.87350081
158MP0000383_abnormal_hair_follicle0.86959550
159MP0002882_abnormal_neuron_morphology0.86901111
160MP0002971_abnormal_brown_adipose0.86866302
161MP0002697_abnormal_eye_size0.86544362
162MP0001661_extended_life_span0.86263124
163MP0005646_abnormal_pituitary_gland0.85735886
164MP0005253_abnormal_eye_physiology0.84787281
165MP0005584_abnormal_enzyme/coenzyme_acti0.84479263
166MP0002877_abnormal_melanocyte_morpholog0.83815175
167MP0001119_abnormal_female_reproductive0.83479569
168MP0002066_abnormal_motor_capabilities/c0.83424503
169MP0003195_calcinosis0.83002841
170MP0004084_abnormal_cardiac_muscle0.82687601
171MP0001905_abnormal_dopamine_level0.81823436
172MP0003935_abnormal_craniofacial_develop0.81416311
173MP0009053_abnormal_anal_canal0.80479912
174MP0008775_abnormal_heart_ventricle0.79868165
175MP0004134_abnormal_chest_morphology0.79216466
176MP0005275_abnormal_skin_tensile0.78841129
177MP0004272_abnormal_basement_membrane0.78612904
178MP0001672_abnormal_embryogenesis/_devel0.77527359
179MP0005380_embryogenesis_phenotype0.77527359
180MP0005195_abnormal_posterior_eye0.77335561
181MP0003786_premature_aging0.76993365
182MP0002085_abnormal_embryonic_tissue0.76448625
183MP0003567_abnormal_fetal_cardiomyocyte0.75199097

Predicted human phenotypes

RankGene SetZ-score
1Pheochromocytoma (HP:0002666)3.78447808
2Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.69579783
3Supranuclear gaze palsy (HP:0000605)3.68076894
4Increased cerebral lipofuscin (HP:0011813)3.58808757
5Neuroendocrine neoplasm (HP:0100634)3.35780152
6Visual hallucinations (HP:0002367)3.35736372
7Myoglobinuria (HP:0002913)3.33471614
8Dysostosis multiplex (HP:0000943)3.32734655
9Neurofibrillary tangles (HP:0002185)3.28285617
10Type II lissencephaly (HP:0007260)3.24459394
11Medial flaring of the eyebrow (HP:0010747)3.22940262
12Abnormality of midbrain morphology (HP:0002418)3.22931465
13Molar tooth sign on MRI (HP:0002419)3.22931465
14Action tremor (HP:0002345)3.07903461
15Increased neuronal autofluorescent lipopigment (HP:0002074)3.06762237
16Pancreatic cysts (HP:0001737)3.05413463
17Pancreatic fibrosis (HP:0100732)3.01096885
18Supernumerary spleens (HP:0009799)2.98109434
19Cerebral inclusion bodies (HP:0100314)2.96999219
20Volvulus (HP:0002580)2.93496857
21Chromsome breakage (HP:0040012)2.86789549
22True hermaphroditism (HP:0010459)2.86515615
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.84783168
24Ketoacidosis (HP:0001993)2.82961054
25Exercise-induced myalgia (HP:0003738)2.78678695
26Aplasia/Hypoplasia of the tibia (HP:0005772)2.77339451
27Aplasia/Hypoplasia of the tongue (HP:0010295)2.76111630
28Colon cancer (HP:0003003)2.74678426
29Nephronophthisis (HP:0000090)2.74144736
30Bifid tongue (HP:0010297)2.70261130
31Cerebellar dysplasia (HP:0007033)2.70107708
32Postural instability (HP:0002172)2.69206218
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.66636854
34Abnormality of the labia minora (HP:0012880)2.64782285
35Congenital primary aphakia (HP:0007707)2.64002625
36Central scotoma (HP:0000603)2.63332423
37Abnormal lung lobation (HP:0002101)2.62296758
38Retinal dysplasia (HP:0007973)2.57853039
39Achilles tendon contracture (HP:0001771)2.57667697
40Short tibia (HP:0005736)2.57320441
41Gait imbalance (HP:0002141)2.57209606
42Depression (HP:0000716)2.51762999
43Difficulty running (HP:0009046)2.50751962
44Retinal atrophy (HP:0001105)2.49353896
45Axonal loss (HP:0003447)2.48268731
46Ketosis (HP:0001946)2.47604893
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.46648570
48Genital tract atresia (HP:0001827)2.46062487
49Termporal pattern (HP:0011008)2.45338651
50Insidious onset (HP:0003587)2.45338651
51Abnormality of chromosome stability (HP:0003220)2.44720489
52Urinary glycosaminoglycan excretion (HP:0003541)2.40394756
53Mucopolysacchariduria (HP:0008155)2.40394756
54Postural tremor (HP:0002174)2.40324957
55Abnormality of the Achilles tendon (HP:0005109)2.39717118
56Abnormality of glycolipid metabolism (HP:0010969)2.39542755
57Abnormality of liposaccharide metabolism (HP:0010968)2.39542755
58Abnormality of glycosphingolipid metabolism (HP:0004343)2.39542755
59Congenital stationary night blindness (HP:0007642)2.38934742
60Nephrogenic diabetes insipidus (HP:0009806)2.38732662
61Abnormality of the renal medulla (HP:0100957)2.35878578
62Menstrual irregularities (HP:0000858)2.34402290
63Vaginal atresia (HP:0000148)2.31670100
64Abnormality of polysaccharide metabolism (HP:0011012)2.30099138
65Abnormality of glycosaminoglycan metabolism (HP:0004371)2.30099138
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.30099138
67Chronic hepatic failure (HP:0100626)2.28925370
68Neoplasm of the peripheral nervous system (HP:0100007)2.27974368
69Meckel diverticulum (HP:0002245)2.26959969
70Macroorchidism (HP:0000053)2.25632422
71Papillary thyroid carcinoma (HP:0002895)2.23478655
72Ectopic kidney (HP:0000086)2.21609971
73Duodenal stenosis (HP:0100867)2.19252362
74Small intestinal stenosis (HP:0012848)2.19252362
75Abnormality of the ileum (HP:0001549)2.18960690
76Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.17995576
77Agitation (HP:0000713)2.13887660
78Hyporeflexia of lower limbs (HP:0002600)2.13726775
79Calf muscle hypertrophy (HP:0008981)2.12676665
80Neuronal loss in central nervous system (HP:0002529)2.12274921
81Psychosis (HP:0000709)2.12103028
82Urinary urgency (HP:0000012)2.10025520
83Ovoid vertebral bodies (HP:0003300)2.09996881
84Medulloblastoma (HP:0002885)2.08789109
85Large for gestational age (HP:0001520)2.08732908
86Focal motor seizures (HP:0011153)2.08607640
87Embryonal renal neoplasm (HP:0011794)2.07559056
88Limb-girdle muscle atrophy (HP:0003797)2.05723578
89Rapidly progressive (HP:0003678)2.05119851
90Intention tremor (HP:0002080)2.04999323
91Abnormal biliary tract physiology (HP:0012439)2.04288278
92Bile duct proliferation (HP:0001408)2.04288278
93Median cleft lip (HP:0000161)2.03283512
94Glioma (HP:0009733)2.03146270
95Preaxial hand polydactyly (HP:0001177)2.02546187
96Asymmetric septal hypertrophy (HP:0001670)2.00764509
97Degeneration of the lateral corticospinal tracts (HP:0002314)2.00012423
98Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.00012423
99Loss of speech (HP:0002371)1.99909648
100Postaxial hand polydactyly (HP:0001162)1.99796098
101Nephroblastoma (Wilms tumor) (HP:0002667)1.99544950
102Exostoses (HP:0100777)1.98557834
103Poor coordination (HP:0002370)1.97659841
104Gonadotropin excess (HP:0000837)1.97555551
105Muscle hypertrophy of the lower extremities (HP:0008968)1.97394089
106Sloping forehead (HP:0000340)1.94600867
107Impaired social interactions (HP:0000735)1.93302340
108Abnormal social behavior (HP:0012433)1.93302340
109Rhabdomyosarcoma (HP:0002859)1.92417778
110Dandy-Walker malformation (HP:0001305)1.92158034
111Sclerocornea (HP:0000647)1.92106000
112Progressive neurologic deterioration (HP:0002344)1.92093184
113Vacuolated lymphocytes (HP:0001922)1.91299165
114Broad foot (HP:0001769)1.91242537
115Focal seizures (HP:0007359)1.91144362
116Esophageal neoplasm (HP:0100751)1.90896643
117Neoplasm of head and neck (HP:0012288)1.90896643
118Postaxial foot polydactyly (HP:0001830)1.89051718
119Long toe (HP:0010511)1.88811368
120Abnormality of the renal cortex (HP:0011035)1.88545903
121Abnormality of methionine metabolism (HP:0010901)1.88465532
122Short middle phalanx of the 5th finger (HP:0004220)1.87989414
123Occipital encephalocele (HP:0002085)1.87732077
124Dysmetria (HP:0001310)1.87138420
125Septo-optic dysplasia (HP:0100842)1.86572140
126Oligodactyly (hands) (HP:0001180)1.86364341
127Frequent falls (HP:0002359)1.86095457
128Oculomotor apraxia (HP:0000657)1.85925258
129Delayed gross motor development (HP:0002194)1.85239760
130Abnormality of the duodenum (HP:0002246)1.85104384
131Muscle stiffness (HP:0003552)1.83602482
132Anencephaly (HP:0002323)1.83583046
133Striae distensae (HP:0001065)1.83057347
134Oligomenorrhea (HP:0000876)1.82985359
135Rhabdomyolysis (HP:0003201)1.82975351
136Narrow forehead (HP:0000341)1.82028132
137Clumsiness (HP:0002312)1.81778622
138Astigmatism (HP:0000483)1.81448261
139Rigidity (HP:0002063)1.80753083
140Optic nerve hypoplasia (HP:0000609)1.80451402
141Methylmalonic acidemia (HP:0002912)1.80092520
142Thyroid carcinoma (HP:0002890)1.79976352
143Tubulointerstitial nephritis (HP:0001970)1.79963089
144Astrocytoma (HP:0009592)1.78224509
145Abnormality of the astrocytes (HP:0100707)1.78224509
146Renal cortical cysts (HP:0000803)1.78155832
147Gowers sign (HP:0003391)1.78063991
148Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.77933643
149Aganglionic megacolon (HP:0002251)1.76704738
150Absence seizures (HP:0002121)1.76173154
151Sensorimotor neuropathy (HP:0007141)1.75834220
152Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.75522577
153Ankle clonus (HP:0011448)1.74339088
154Hyperglycinemia (HP:0002154)1.73786990
155Prominent nasal bridge (HP:0000426)1.73429351
156Congenital hepatic fibrosis (HP:0002612)1.72288740
157Hypoplastic pelvis (HP:0008839)1.71894614
158Small hand (HP:0200055)1.71556565
159Progressive macrocephaly (HP:0004481)1.69782671
160Anxiety (HP:0000739)1.69558987
161Hyperinsulinemic hypoglycemia (HP:0000825)1.69001603
162Hypothermia (HP:0002045)1.68991557
163Slow saccadic eye movements (HP:0000514)1.68646246
164Neoplasm of the oral cavity (HP:0100649)1.68348482
165EMG: myopathic abnormalities (HP:0003458)1.68010152
166Limb dystonia (HP:0002451)1.67722514
167Dialeptic seizures (HP:0011146)1.67335462
168Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.66808648
169Multicystic kidney dysplasia (HP:0000003)1.66783330
170Cortical dysplasia (HP:0002539)1.66484712
171Protuberant abdomen (HP:0001538)1.66235260
172Centrally nucleated skeletal muscle fibers (HP:0003687)1.65872177
173Bradykinesia (HP:0002067)1.65621058
174Increased CSF lactate (HP:0002490)1.65408755
175Fair hair (HP:0002286)1.65397623
176Generalized tonic-clonic seizures (HP:0002069)1.65037060
177Drooling (HP:0002307)1.64589739
178Acute necrotizing encephalopathy (HP:0006965)1.64487934
179Global brain atrophy (HP:0002283)1.64310183
180Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.64292081
181Abnormality of aspartate family amino acid metabolism (HP:0010899)1.64156456
182Microglossia (HP:0000171)1.63953454
183Poor eye contact (HP:0000817)1.63760991
184Mutism (HP:0002300)1.63664435
185Late onset (HP:0003584)1.63259888
186Ragged-red muscle fibers (HP:0003200)1.63242930
187Scanning speech (HP:0002168)1.61868097
188Abnormality of the corticospinal tract (HP:0002492)1.61264355
189Abnormal ciliary motility (HP:0012262)1.59838005
190Facial hemangioma (HP:0000329)1.58441731
191Cystic liver disease (HP:0006706)1.58206835
192Abnormal auditory evoked potentials (HP:0006958)1.57703464
193Abnormality of the septum pellucidum (HP:0007375)1.57675966
194Triphalangeal thumb (HP:0001199)1.56791864
195Acute encephalopathy (HP:0006846)1.55348340
196Aplasia/Hypoplasia of the lens (HP:0008063)1.55155445
197Highly arched eyebrow (HP:0002553)1.55038256
198Dyschromatopsia (HP:0007641)1.54065044
199Neoplasm of the colon (HP:0100273)1.53379435

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.84270893
2MAP3K93.50283861
3FRK3.29587212
4MAP3K133.27475302
5NTRK12.57673678
6TRIM282.40951295
7EIF2AK32.38866785
8PNCK2.31796492
9KSR22.27762945
10BUB12.23522917
11ACVR1B2.13948432
12RIPK12.06158054
13BRSK22.03911974
14WNK32.02607689
15PKN21.98405526
16TTK1.95778264
17BCR1.92551180
18PHKG11.87788011
19PHKG21.87788011
20FLT31.86400200
21SRPK11.86092130
22BMPR1B1.84869070
23NUAK11.81638533
24ZAK1.79535088
25PLK31.78793887
26MAP4K21.78558160
27PLK41.77888889
28FES1.76564065
29LMTK21.75598392
30MAP3K21.75338268
31EIF2AK11.74649729
32MKNK11.71903867
33WEE11.70669049
34PBK1.68101605
35CASK1.68086970
36TAOK31.66969706
37MKNK21.64163284
38ERN11.60588648
39MINK11.56818565
40INSRR1.53419550
41PRKD31.53129892
42SCYL21.52374675
43CAMKK21.51168251
44RIPK41.50202275
45STK31.45571566
46PAK61.45456546
47CAMKK11.43288894
48STK38L1.34786389
49MST41.34229680
50ERBB31.33055325
51EPHB11.33051572
52STK161.32216207
53RET1.31701729
54NTRK31.31156490
55MAPKAPK51.28583277
56TTN1.27623325
57MAPK151.25979049
58KSR11.24491699
59PLK11.19702864
60HIPK21.19689651
61MATK1.18950094
62NEK91.18938381
63PTK61.18418813
64CDC71.17128143
65CAMK1D1.14868964
66VRK11.14517436
67NEK11.13430891
68UHMK11.12423571
69NEK21.11742404
70PDK21.10821306
71CCNB11.09646690
72PDGFRB1.06688753
73PAK31.06403247
74PDGFRA1.04952354
75LRRK21.03099502
76MAP2K41.01488195
77CSNK1G11.01298496
78STK241.00764482
79WNK10.99342954
80CAMK1G0.98769828
81CSNK1G30.98046206
82MET0.97839190
83TGFBR10.94777938
84CSNK1A1L0.93837194
85DMPK0.92722839
86PDPK10.92449393
87MAP3K40.91376008
88MAP3K100.89930347
89PDK10.88215556
90EPHA40.86080083
91MAP3K10.83216847
92EIF2AK20.82944578
93ARAF0.82313330
94OXSR10.81410180
95CAMK2D0.80639346
96BRSK10.79790602
97SGK2230.78574180
98SGK4940.78574180
99CHEK20.77714717
100BLK0.76806360
101CDK50.76172232
102FER0.75814977
103DAPK20.74996888
104PRKCH0.74314009
105KIT0.73933717
106PRKCE0.73826913
107AKT30.72500798
108MAP2K70.69664124
109ATR0.69344670
110ATM0.68369335
111PRKD10.67498321
112LIMK10.66956129
113MAP3K70.66814905
114ZAP700.66389571
115TSSK60.65980029
116YES10.64309233
117CDK190.64267159
118ERBB40.63545264
119PRKCQ0.63077914
120MAP3K50.62076665
121FYN0.61409277
122ADRBK20.61370917
123CSNK1G20.61342349
124STK390.60642048
125PINK10.59560081
126CSK0.59038787
127NTRK20.58515037
128BRD40.57411431
129STK100.57130038
130TYRO30.56834546
131RPS6KA40.56517475
132VRK20.56295607
133FGFR10.56200352
134AURKB0.56116173
135JAK20.55503487
136WNK40.55253982
137PIK3CA0.54865817
138PIK3CG0.54171507
139MARK10.53876213
140CHEK10.53704220
141MUSK0.53102771
142DYRK30.51912393
143LATS10.50716118
144PTK2B0.50665043
145MAP3K120.50478025
146MYLK0.50072986
147SGK30.49725367
148PRKG20.49676302
149PLK20.47882278
150FGFR20.45963977
151SYK0.45919376
152CAMK2A0.44892999
153SGK10.44858319
154JAK10.44494712
155CDK140.42656431
156TAF10.40843713
157TGFBR20.40547233
158GRK10.40418496
159DYRK20.40224220
160PRKACB0.39664176
161MAPK130.37468156
162IRAK20.37092015
163SRC0.37082989
164PRKCG0.36904183
165CAMK10.36174719
166TNIK0.36032642
167ADRBK10.35893023
168ROCK10.35746887
169ROCK20.35739642
170BCKDK0.34323627
171AURKA0.34291127
172PTK20.34248785
173PKN10.34016333
174NEK60.33617268
175RAF10.29710439

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.20901583
2Mismatch repair_Homo sapiens_hsa034302.93181503
3Non-homologous end-joining_Homo sapiens_hsa034502.78665430
4Fanconi anemia pathway_Homo sapiens_hsa034602.72156089
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.63187648
6Homologous recombination_Homo sapiens_hsa034402.58364222
7Basal transcription factors_Homo sapiens_hsa030222.57708876
8Nitrogen metabolism_Homo sapiens_hsa009102.39347702
9Nucleotide excision repair_Homo sapiens_hsa034202.34169134
10Cell cycle_Homo sapiens_hsa041102.16356699
11Synaptic vesicle cycle_Homo sapiens_hsa047212.14392586
12DNA replication_Homo sapiens_hsa030302.13220716
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.11377929
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07443488
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.02428442
16RNA degradation_Homo sapiens_hsa030182.00410663
17Proteasome_Homo sapiens_hsa030501.99589974
18RNA transport_Homo sapiens_hsa030131.95515690
19Steroid biosynthesis_Homo sapiens_hsa001001.95038851
20Sulfur metabolism_Homo sapiens_hsa009201.77742190
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77123515
22Lysosome_Homo sapiens_hsa041421.74782851
23One carbon pool by folate_Homo sapiens_hsa006701.74183478
24Insulin secretion_Homo sapiens_hsa049111.71938922
25RNA polymerase_Homo sapiens_hsa030201.68411949
26GABAergic synapse_Homo sapiens_hsa047271.67545422
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66897163
28Oocyte meiosis_Homo sapiens_hsa041141.66610828
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62820601
30Base excision repair_Homo sapiens_hsa034101.56338551
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.55503461
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53257958
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.52868336
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.50154975
35Olfactory transduction_Homo sapiens_hsa047401.48726824
36Propanoate metabolism_Homo sapiens_hsa006401.43212146
37Type II diabetes mellitus_Homo sapiens_hsa049301.42708106
38p53 signaling pathway_Homo sapiens_hsa041151.42147787
39Cholinergic synapse_Homo sapiens_hsa047251.39932788
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.37519828
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.35608959
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.35005418
43Cocaine addiction_Homo sapiens_hsa050301.33622583
44Circadian entrainment_Homo sapiens_hsa047131.31507506
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30792703
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.29565530
47Dopaminergic synapse_Homo sapiens_hsa047281.29443035
48Vibrio cholerae infection_Homo sapiens_hsa051101.26630572
49Selenocompound metabolism_Homo sapiens_hsa004501.24913707
50Parkinsons disease_Homo sapiens_hsa050121.23670379
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23663077
52Huntingtons disease_Homo sapiens_hsa050161.22860774
53Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22631241
54Oxidative phosphorylation_Homo sapiens_hsa001901.21504206
55Fatty acid degradation_Homo sapiens_hsa000711.21458974
56Phototransduction_Homo sapiens_hsa047441.20597828
57Glycosaminoglycan degradation_Homo sapiens_hsa005311.17527437
58Fatty acid metabolism_Homo sapiens_hsa012121.14734619
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14665290
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13859135
61Morphine addiction_Homo sapiens_hsa050321.13456707
62Pyrimidine metabolism_Homo sapiens_hsa002401.10703275
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.10330233
64Renin secretion_Homo sapiens_hsa049241.08336479
65Spliceosome_Homo sapiens_hsa030401.07727861
66Gastric acid secretion_Homo sapiens_hsa049711.07496784
67Purine metabolism_Homo sapiens_hsa002301.06604039
68Hedgehog signaling pathway_Homo sapiens_hsa043401.06512501
69Glutamatergic synapse_Homo sapiens_hsa047241.04180763
70Adipocytokine signaling pathway_Homo sapiens_hsa049201.03692807
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03438146
72Amphetamine addiction_Homo sapiens_hsa050311.03157834
73Collecting duct acid secretion_Homo sapiens_hsa049661.02813731
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97116641
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.96582417
76Phagosome_Homo sapiens_hsa041450.96138438
77Nicotine addiction_Homo sapiens_hsa050330.95000873
78mRNA surveillance pathway_Homo sapiens_hsa030150.93599200
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93172500
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91891873
81TGF-beta signaling pathway_Homo sapiens_hsa043500.91509000
82Serotonergic synapse_Homo sapiens_hsa047260.90255744
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88716995
84Salivary secretion_Homo sapiens_hsa049700.88562975
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86374854
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83079962
87Pancreatic secretion_Homo sapiens_hsa049720.82537683
88Insulin resistance_Homo sapiens_hsa049310.81380990
89Estrogen signaling pathway_Homo sapiens_hsa049150.81005384
90Fatty acid biosynthesis_Homo sapiens_hsa000610.80584363
91beta-Alanine metabolism_Homo sapiens_hsa004100.79875332
92Dilated cardiomyopathy_Homo sapiens_hsa054140.79246925
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78802071
94Prion diseases_Homo sapiens_hsa050200.77810677
95Hippo signaling pathway_Homo sapiens_hsa043900.77223765
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76480487
97Long-term potentiation_Homo sapiens_hsa047200.76266515
98Taste transduction_Homo sapiens_hsa047420.75712187
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.74904368
100Peroxisome_Homo sapiens_hsa041460.73337674
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73077311
102N-Glycan biosynthesis_Homo sapiens_hsa005100.72651462
103Gap junction_Homo sapiens_hsa045400.72117917
104PPAR signaling pathway_Homo sapiens_hsa033200.71974547
105Long-term depression_Homo sapiens_hsa047300.71724211
106Oxytocin signaling pathway_Homo sapiens_hsa049210.71677888
107Glioma_Homo sapiens_hsa052140.71121625
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.71017956
109Calcium signaling pathway_Homo sapiens_hsa040200.70987633
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70711608
111GnRH signaling pathway_Homo sapiens_hsa049120.70452984
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70126903
113Regulation of autophagy_Homo sapiens_hsa041400.68545943
114Cardiac muscle contraction_Homo sapiens_hsa042600.66997467
115Butanoate metabolism_Homo sapiens_hsa006500.66695654
116Glutathione metabolism_Homo sapiens_hsa004800.66285026
117Glucagon signaling pathway_Homo sapiens_hsa049220.66099969
118Osteoclast differentiation_Homo sapiens_hsa043800.65210759
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65063189
120Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64758124
121Basal cell carcinoma_Homo sapiens_hsa052170.64084524
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64013268
123ABC transporters_Homo sapiens_hsa020100.63916483
124Bile secretion_Homo sapiens_hsa049760.63475452
125Other glycan degradation_Homo sapiens_hsa005110.62953362
126Histidine metabolism_Homo sapiens_hsa003400.62353735
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.62099466
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61921260
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61666244
130Renal cell carcinoma_Homo sapiens_hsa052110.61609871
131cAMP signaling pathway_Homo sapiens_hsa040240.60997109
132Thyroid hormone synthesis_Homo sapiens_hsa049180.60650612
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60180709
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60076715
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59984267
136Endocytosis_Homo sapiens_hsa041440.59795183
137Alzheimers disease_Homo sapiens_hsa050100.59767108
138Platelet activation_Homo sapiens_hsa046110.59103945
139Vitamin B6 metabolism_Homo sapiens_hsa007500.57122220
140Insulin signaling pathway_Homo sapiens_hsa049100.56529929
141Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56346881
142Circadian rhythm_Homo sapiens_hsa047100.56126040
143Pyruvate metabolism_Homo sapiens_hsa006200.55889779
144Fatty acid elongation_Homo sapiens_hsa000620.54553207
145Dorso-ventral axis formation_Homo sapiens_hsa043200.53157460
146Staphylococcus aureus infection_Homo sapiens_hsa051500.52335969
147Vascular smooth muscle contraction_Homo sapiens_hsa042700.51865604
148Metabolic pathways_Homo sapiens_hsa011000.51813142
149Alcoholism_Homo sapiens_hsa050340.50791076
150Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50621062
151Starch and sucrose metabolism_Homo sapiens_hsa005000.49592394
152Lysine degradation_Homo sapiens_hsa003100.48750038
153Chronic myeloid leukemia_Homo sapiens_hsa052200.48622698
154Folate biosynthesis_Homo sapiens_hsa007900.48460396
155Tryptophan metabolism_Homo sapiens_hsa003800.47933457
156Carbon metabolism_Homo sapiens_hsa012000.47898243
157B cell receptor signaling pathway_Homo sapiens_hsa046620.46485103
158Ether lipid metabolism_Homo sapiens_hsa005650.45345615
159Primary bile acid biosynthesis_Homo sapiens_hsa001200.44347172
160Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41404014
161ECM-receptor interaction_Homo sapiens_hsa045120.41328310
162Wnt signaling pathway_Homo sapiens_hsa043100.38725350
163Melanoma_Homo sapiens_hsa052180.36789180
164Caffeine metabolism_Homo sapiens_hsa002320.35319609
165MicroRNAs in cancer_Homo sapiens_hsa052060.34192261
166Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33919287
167PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29774811
168Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27394702
169Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26617175
170Ribosome_Homo sapiens_hsa030100.25709689

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