WDR44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that interacts with the small GTPase rab11. A similar protein in rat binds the GTP-containing active form of rab11. This protein may play a role in endosome recycling. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.38487479
2nuclear pore organization (GO:0006999)5.40942484
3mitotic sister chromatid cohesion (GO:0007064)4.91994537
4modulation by symbiont of host defense response (GO:0052031)4.80729201
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.80729201
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.80729201
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.80729201
8modulation by symbiont of host immune response (GO:0052553)4.80729201
9positive regulation by symbiont of host defense response (GO:0052509)4.80729201
10pore complex assembly (GO:0046931)4.60893051
11thrombin receptor signaling pathway (GO:0070493)4.08605793
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.04555717
13microglial cell activation (GO:0001774)3.86082264
14regulation of Golgi to plasma membrane protein transport (GO:0042996)3.81503384
15protein localization to kinetochore (GO:0034501)3.68154693
16positive regulation of gamma-delta T cell activation (GO:0046645)3.65198460
17macrophage activation involved in immune response (GO:0002281)3.58074210
18ribosome assembly (GO:0042255)3.52871967
19regulation of histone H3-K9 methylation (GO:0051570)3.49405043
20COPII vesicle coating (GO:0048208)3.47961196
21regulation of transforming growth factor beta2 production (GO:0032909)3.45275771
22protein localization to chromosome, centromeric region (GO:0071459)3.39187707
23mitotic metaphase plate congression (GO:0007080)3.34200437
24protein neddylation (GO:0045116)3.31646993
25DNA synthesis involved in DNA repair (GO:0000731)3.31116378
26mesodermal cell differentiation (GO:0048333)3.30003528
27regulation of B cell receptor signaling pathway (GO:0050855)3.26812692
28response to host immune response (GO:0052572)3.26381227
29response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.26381227
30regulation of germinal center formation (GO:0002634)3.25159134
31regulation of centriole replication (GO:0046599)3.25075645
32germinal center formation (GO:0002467)3.17900462
33regulation of dendritic cell antigen processing and presentation (GO:0002604)3.17735888
34histone H3-K4 trimethylation (GO:0080182)3.14875583
35negative regulation of neurotransmitter secretion (GO:0046929)3.08514058
36regulation of interferon-beta biosynthetic process (GO:0045357)3.08482275
37negative regulation of fibroblast apoptotic process (GO:2000270)3.08145002
38superoxide anion generation (GO:0042554)3.06487628
39negative regulation of DNA repair (GO:0045738)3.05321783
40regulation of RNA export from nucleus (GO:0046831)3.02130043
41response to host defenses (GO:0052200)2.97490856
42response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.97490856
43response to host (GO:0075136)2.97490856
44establishment of chromosome localization (GO:0051303)2.97228212
45histone H3-K36 demethylation (GO:0070544)2.96623506
46negative regulation of histone methylation (GO:0031061)2.94949399
47synapsis (GO:0007129)2.94248570
48regulation of cAMP-dependent protein kinase activity (GO:2000479)2.94233859
49regulation of establishment of cell polarity (GO:2000114)2.93123097
50Rap protein signal transduction (GO:0032486)2.91819349
51negative regulation of protein localization to plasma membrane (GO:1903077)2.91156439
52positive regulation of antigen processing and presentation (GO:0002579)2.90513911
53negative regulation of homotypic cell-cell adhesion (GO:0034111)2.88737903
54B cell homeostasis (GO:0001782)2.84181408
55neutrophil activation involved in immune response (GO:0002283)2.83217922
56histone H3-K9 demethylation (GO:0033169)2.82203521
57vesicle coating (GO:0006901)2.81653658
58hippo signaling (GO:0035329)2.80366108
59regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.78860490
60metaphase plate congression (GO:0051310)2.77554896
61protein localization to microtubule (GO:0035372)2.76915047
62negative regulation of norepinephrine secretion (GO:0010700)2.76554478
63interferon-gamma production (GO:0032609)2.76448355
64macrophage activation (GO:0042116)2.75950830
65phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.75567336
66clathrin coat assembly (GO:0048268)2.75373381
67cytoplasmic mRNA processing body assembly (GO:0033962)2.73874553
68hypotonic response (GO:0006971)2.73623606
69positive regulation of cardiac muscle hypertrophy (GO:0010613)2.72315457
70positive regulation of muscle hypertrophy (GO:0014742)2.72315457
71interleukin-6-mediated signaling pathway (GO:0070102)2.71945345
72regulation of integrin-mediated signaling pathway (GO:2001044)2.71866534
73regulation of helicase activity (GO:0051095)2.71316677
74negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.70607511
75platelet aggregation (GO:0070527)2.70587037
76T-helper cell differentiation (GO:0042093)2.70249019
77CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.70249019
78regulation of nucleobase-containing compound transport (GO:0032239)2.69838339
79positive regulation of interleukin-1 beta secretion (GO:0050718)2.68835877
80positive regulation of cellular amide metabolic process (GO:0034250)2.66799773
81G-protein coupled receptor internalization (GO:0002031)2.65820530
82neutrophil activation (GO:0042119)2.65691812
83protein prenylation (GO:0018342)2.65444335
84prenylation (GO:0097354)2.65444335
85myeloid cell activation involved in immune response (GO:0002275)2.63246273
86regulation of Rac protein signal transduction (GO:0035020)2.62795486
87positive regulation of receptor recycling (GO:0001921)2.62752597
88regulation of alpha-beta T cell proliferation (GO:0046640)2.61491404
89cellular protein complex localization (GO:0034629)2.60704610
90positive regulation of SMAD protein import into nucleus (GO:0060391)2.58362202
91negative regulation of mast cell activation (GO:0033004)2.58134847
92negative T cell selection (GO:0043383)2.57550035
93cellular response to interleukin-15 (GO:0071350)2.55075936
94positive regulation of defense response to virus by host (GO:0002230)2.55032876
95response to peptidoglycan (GO:0032494)2.54340239
96B cell receptor signaling pathway (GO:0050853)2.54304134
97G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.53567987
98interferon-gamma-mediated signaling pathway (GO:0060333)2.53098138
99negative thymic T cell selection (GO:0045060)2.52936040
100regulation of platelet aggregation (GO:0090330)2.52837795
101phagocytosis, engulfment (GO:0006911)2.52012397
102negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.51842228
103negative regulation of cell killing (GO:0031342)2.51842228
104sister chromatid cohesion (GO:0007062)2.51251536
105cell adhesion mediated by integrin (GO:0033627)2.49058623
106regulation of antigen processing and presentation (GO:0002577)2.48693907
107positive T cell selection (GO:0043368)2.47387195
108regulation of DNA endoreduplication (GO:0032875)2.46657581
109NLS-bearing protein import into nucleus (GO:0006607)2.45601149
110regulation of mast cell degranulation (GO:0043304)2.44941293
111dendritic cell chemotaxis (GO:0002407)2.44523861
112granulocyte activation (GO:0036230)2.44031383
113regulation of platelet activation (GO:0010543)2.42653115
114positive regulation of interleukin-1 secretion (GO:0050716)2.42450418
115sequestering of extracellular ligand from receptor (GO:0035581)2.42237260
116regulation of acyl-CoA biosynthetic process (GO:0050812)2.42217919
117monoubiquitinated protein deubiquitination (GO:0035520)2.41604828
118regulation of mast cell activation (GO:0033003)2.41320293
119regulation of clathrin-mediated endocytosis (GO:2000369)2.40932067
120interleukin-1-mediated signaling pathway (GO:0070498)2.40163379
121positive thymic T cell selection (GO:0045059)2.40118851
122protein localization to chromosome (GO:0034502)2.39739269
123N-terminal protein amino acid acetylation (GO:0006474)2.39663995
124pericardium development (GO:0060039)2.39279321
125dendritic cell migration (GO:0036336)2.39128840
126regulation of receptor recycling (GO:0001919)2.38810915
127detection of molecule of bacterial origin (GO:0032490)2.38622687
128peptidyl-lysine trimethylation (GO:0018023)2.38529256
129respiratory burst (GO:0045730)2.37933255
130regulation of mast cell activation involved in immune response (GO:0033006)2.37924733
131regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.37694081
132beta-amyloid metabolic process (GO:0050435)2.37530489
133NIK/NF-kappaB signaling (GO:0038061)2.37139348
134regulation of cofactor metabolic process (GO:0051193)2.36823419
135regulation of coenzyme metabolic process (GO:0051196)2.36823419
136protein localization to cell surface (GO:0034394)2.36611296
137tolerance induction (GO:0002507)2.36437359
138positive regulation of interleukin-1 beta production (GO:0032731)2.36235023
139sister chromatid segregation (GO:0000819)2.36162508
140corticosteroid receptor signaling pathway (GO:0031958)2.36105782
141T cell migration (GO:0072678)2.35811117
142leukocyte aggregation (GO:0070486)2.34846329
143mast cell activation (GO:0045576)2.34281335
144positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.33772115
145positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.33639920
146regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.33589692
147regulation of response to tumor cell (GO:0002834)2.33339974
148positive regulation of response to tumor cell (GO:0002836)2.33339974
149positive regulation of immune response to tumor cell (GO:0002839)2.33339974
150regulation of immune response to tumor cell (GO:0002837)2.33339974
151phospholipid scrambling (GO:0017121)2.33200197
152regulation of interleukin-1 beta secretion (GO:0050706)2.32972080
153CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.32454991
154positive regulation of interleukin-12 production (GO:0032735)2.32392502
155regulation of mitotic metaphase/anaphase transition (GO:0030071)2.32215636
156regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.32215636
157positive regulation of histone methylation (GO:0031062)2.31332678
158positive regulation of mast cell activation (GO:0033005)2.31262415
159peptidyl-threonine modification (GO:0018210)2.31115679
160regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.30886803
161positive regulation of histone H3-K4 methylation (GO:0051571)2.30506643
162positive regulation of B cell proliferation (GO:0030890)2.29678577
163Golgi transport vesicle coating (GO:0048200)2.28517699
164COPI coating of Golgi vesicle (GO:0048205)2.28517699
165positive regulation of interferon-alpha production (GO:0032727)2.28427491
166positive regulation of interleukin-17 production (GO:0032740)2.28208570
167positive regulation of mast cell activation involved in immune response (GO:0033008)2.27980911
168positive regulation of mast cell degranulation (GO:0043306)2.27980911
169regulation of establishment or maintenance of cell polarity (GO:0032878)2.27505958
170response to muramyl dipeptide (GO:0032495)2.27489294
171positive regulation of endothelial cell differentiation (GO:0045603)2.27325281
172positive regulation of heat generation (GO:0031652)2.27137219
173fibroblast migration (GO:0010761)2.26866395
174pre-miRNA processing (GO:0031054)2.26239548
175myeloid leukocyte activation (GO:0002274)2.26211004
176regulation of steroid hormone biosynthetic process (GO:0090030)2.26008521
177embryonic process involved in female pregnancy (GO:0060136)2.25060890
178establishment of endothelial barrier (GO:0061028)2.24362957
179response to interleukin-15 (GO:0070672)2.24186377
180alpha-beta T cell differentiation involved in immune response (GO:0002293)2.24147823
181alpha-beta T cell activation involved in immune response (GO:0002287)2.24147823
182T cell differentiation involved in immune response (GO:0002292)2.24147823
183platelet formation (GO:0030220)2.23921560
184ER to Golgi vesicle-mediated transport (GO:0006888)2.23656587
185adenosine receptor signaling pathway (GO:0001973)2.22503937
186positive regulation of granulocyte differentiation (GO:0030854)2.22449263
187nuclear envelope disassembly (GO:0051081)2.21898345
188membrane disassembly (GO:0030397)2.21898345
189B cell proliferation (GO:0042100)2.21809155
190positive regulation of alpha-beta T cell proliferation (GO:0046641)2.21657561
191regulation of interferon-alpha production (GO:0032647)2.21347991
192regulation of B cell proliferation (GO:0030888)2.20787000
193detection of other organism (GO:0098543)2.19679309
194regulation of fever generation (GO:0031620)2.19273520
195regulation of cell communication by electrical coupling (GO:0010649)2.18480085
196leukocyte tethering or rolling (GO:0050901)2.18473221

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.02702684
2E2F7_22180533_ChIP-Seq_HELA_Human3.88692012
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.58052763
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.18595049
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.95058750
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.85907489
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.75265494
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.71293814
9PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.61531998
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.55668005
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.51096094
12GBX2_23144817_ChIP-Seq_PC3_Human2.46775865
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.45694688
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.38744277
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.38362474
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.37066536
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.28599512
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23572827
19* IRF8_27001747_Chip-Seq_BMDM_Mouse2.16972772
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16402710
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.15015504
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14015324
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.11314779
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.10839375
25PCGF2_27294783_Chip-Seq_ESCs_Mouse2.08537424
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.99091644
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.98460820
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97708005
29SALL4_18804426_ChIP-ChIP_XEN_Mouse1.92291379
30RUNX_20019798_ChIP-Seq_JUKART_Human1.91881346
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.88525040
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78561452
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.75556840
34SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.72156225
35TAF15_26573619_Chip-Seq_HEK293_Human1.71637743
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.70223996
37BRD4_25478319_ChIP-Seq_HGPS_Human1.70066516
38TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.67761995
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.67269511
40NANOG_18555785_Chip-Seq_ESCs_Mouse1.66805476
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66322977
42* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.65915939
43* ELK1_19687146_ChIP-ChIP_HELA_Human1.64881362
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.63509754
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60086684
46TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.55823856
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.55521350
48AR_21909140_ChIP-Seq_LNCAP_Human1.55368880
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54750512
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.54314733
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.54314733
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53622758
53P300_19829295_ChIP-Seq_ESCs_Human1.53359863
54SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.48212866
55SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.48212866
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47595774
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.46602203
58EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.46430690
59* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46197407
60* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.45520087
61E2F1_18555785_Chip-Seq_ESCs_Mouse1.45301590
62SMAD4_21799915_ChIP-Seq_A2780_Human1.44948867
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.42641321
64FUS_26573619_Chip-Seq_HEK293_Human1.42570394
65SUZ12_18555785_Chip-Seq_ESCs_Mouse1.41056469
66FOXM1_26456572_ChIP-Seq_MCF-7_Human1.40241791
67P53_22387025_ChIP-Seq_ESCs_Mouse1.36450468
68CMYC_18555785_Chip-Seq_ESCs_Mouse1.35442668
69GATA1_22025678_ChIP-Seq_K562_Human1.35368990
70SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34930516
71* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.33747203
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33390562
73STAT3_18555785_Chip-Seq_ESCs_Mouse1.32835481
74IGF1R_20145208_ChIP-Seq_DFB_Human1.32488785
75NMYC_18555785_Chip-Seq_ESCs_Mouse1.30631431
76VDR_24787735_ChIP-Seq_THP-1_Human1.30582429
77ER_23166858_ChIP-Seq_MCF-7_Human1.29943125
78EWS_26573619_Chip-Seq_HEK293_Human1.29942200
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.29559236
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27155879
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.26966909
82STAT3_23295773_ChIP-Seq_U87_Human1.26743759
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25439175
84FOXM1_23109430_ChIP-Seq_U2OS_Human1.24749040
85EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23979923
86EP300_21415370_ChIP-Seq_HL-1_Mouse1.23334393
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22394797
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21872534
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20462512
90SOX2_18555785_Chip-Seq_ESCs_Mouse1.18998226
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18624404
92TCF4_23295773_ChIP-Seq_U87_Human1.17560800
93CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16571378
94TFEB_21752829_ChIP-Seq_HELA_Human1.16230240
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16106761
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15978677
97RUNX1_27457419_Chip-Seq_LIVER_Mouse1.15494101
98P300_18555785_Chip-Seq_ESCs_Mouse1.15419420
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.13405209
100ESR1_20079471_ChIP-ChIP_T-47D_Human1.13376305
101OCT4_18555785_Chip-Seq_ESCs_Mouse1.13187437
102AHR_22903824_ChIP-Seq_MCF-7_Human1.13025963
103SCL_19346495_ChIP-Seq_HPC-7_Human1.12450364
104* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11295683
105PU1_27457419_Chip-Seq_LIVER_Mouse1.10605148
106FOXO3_23340844_ChIP-Seq_DLD1_Human1.10531013
107FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09692889
108MYB_26560356_Chip-Seq_TH2_Human1.09690203
109ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08940817
110MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08918393
111FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08627290
112AR_25329375_ChIP-Seq_VCAP_Human1.08311648
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08103444
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06813481
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06774896
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06774896
117SALL4_22934838_ChIP-ChIP_CD34+_Human1.05304719
118PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04587115
119* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04555199
120PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04044055
121GATA4_21415370_ChIP-Seq_HL-1_Mouse1.03476323
122RXR_22108803_ChIP-Seq_LS180_Human1.03215321
123TP53_16413492_ChIP-PET_HCT116_Human1.01499270
124ZFX_18555785_Chip-Seq_ESCs_Mouse1.01296719
125* TP63_23658742_ChIP-Seq_EP156T_Human1.01035932
126PRDM14_20953172_ChIP-Seq_ESCs_Human1.00429649
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00330746
128OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00040818
129PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99950953
130* SMAD3_21741376_ChIP-Seq_EPCs_Human0.99743395
131TCF4_18268006_ChIP-ChIP_LS174T_Human0.99053770
132SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98799326
133CTCF_18555785_Chip-Seq_ESCs_Mouse0.98787675
134NOTCH1_21737748_ChIP-Seq_TLL_Human0.98611153
135KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98318691
136KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98318691
137KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98318691
138MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97663687
139CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97601412
140TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97246571
141CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96853218
142PU_27001747_Chip-Seq_BMDM_Mouse0.96731835
143SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95533904
144SMAD1_18555785_Chip-Seq_ESCs_Mouse0.95429868
145* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94278197
146KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.93971304
147SPI1_23127762_ChIP-Seq_K562_Human0.93946407
148CJUN_26792858_Chip-Seq_BT549_Human0.91502181
149YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91450517
150GATA2_19941826_ChIP-Seq_K562_Human0.90967127
151CRX_20693478_ChIP-Seq_RETINA_Mouse0.90887116
152EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89650240

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.98294542
2MP0008004_abnormal_stomach_pH3.78877744
3MP0010352_gastrointestinal_tract_polyps3.56892740
4MP0003566_abnormal_cell_adhesion3.45048942
5MP0005671_abnormal_response_to3.24305349
6MP0001835_abnormal_antigen_presentation3.17264875
7MP0003787_abnormal_imprinting2.87192719
8MP0006054_spinal_hemorrhage2.71624705
9MP0002877_abnormal_melanocyte_morpholog2.69265640
10MP0009697_abnormal_copulation2.49764698
11MP0004084_abnormal_cardiac_muscle2.45445669
12MP0003890_abnormal_embryonic-extraembry2.40727440
13MP0005387_immune_system_phenotype2.40576517
14MP0001790_abnormal_immune_system2.40576517
15MP0003724_increased_susceptibility_to2.33780876
16MP0001800_abnormal_humoral_immune2.30219105
17MP0005000_abnormal_immune_tolerance2.28176885
18MP0002452_abnormal_antigen_presenting2.21562181
19MP0002419_abnormal_innate_immunity2.20936997
20MP0002148_abnormal_hypersensitivity_rea2.19949692
21MP0005310_abnormal_salivary_gland2.19805401
22MP0004957_abnormal_blastocyst_morpholog2.17318609
23MP0000015_abnormal_ear_pigmentation2.16007332
24MP0001188_hyperpigmentation2.14334637
25MP0002277_abnormal_respiratory_mucosa2.13817006
26MP0008057_abnormal_DNA_replication2.12688690
27MP0002723_abnormal_immune_serum2.07161437
28MP0002396_abnormal_hematopoietic_system2.03891877
29MP0001819_abnormal_immune_cell2.02597017
30MP0002420_abnormal_adaptive_immunity2.02321049
31MP0000465_gastrointestinal_hemorrhage1.91874515
32MP0010234_abnormal_vibrissa_follicle1.91669502
33MP0009785_altered_susceptibility_to1.90381023
34MP0004510_myositis1.80300365
35MP0005025_abnormal_response_to1.79493708
36MP0004272_abnormal_basement_membrane1.78548834
37MP0001730_embryonic_growth_arrest1.76734911
38MP0008438_abnormal_cutaneous_collagen1.73625827
39MP0002166_altered_tumor_susceptibility1.72996192
40MP0002009_preneoplasia1.71324697
41MP0006082_CNS_inflammation1.69276085
42MP0002006_tumorigenesis1.69275458
43MP0005275_abnormal_skin_tensile1.69166071
44MP0008058_abnormal_DNA_repair1.63488987
45MP0001915_intracranial_hemorrhage1.61091334
46MP0002398_abnormal_bone_marrow1.60982412
47MP0004036_abnormal_muscle_relaxation1.60527460
48MP0001986_abnormal_taste_sensitivity1.57698662
49MP0010094_abnormal_chromosome_stability1.55252115
50MP0005171_absent_coat_pigmentation1.53301155
51MP0000716_abnormal_immune_system1.52445224
52MP0004484_altered_response_of1.52125140
53MP0003111_abnormal_nucleus_morphology1.51693530
54MP0003763_abnormal_thymus_physiology1.50284521
55MP0005464_abnormal_platelet_physiology1.49935412
56MP0003436_decreased_susceptibility_to1.47623949
57MP0002405_respiratory_system_inflammati1.47241864
58MP0003172_abnormal_lysosome_physiology1.47112792
59MP0002735_abnormal_chemical_nociception1.46163523
60MP0000685_abnormal_immune_system1.46047789
61MP0001851_eye_inflammation1.44704379
62MP0004233_abnormal_muscle_weight1.43668437
63MP0008260_abnormal_autophagy1.42890820
64MP0008932_abnormal_embryonic_tissue1.42862801
65MP0005380_embryogenesis_phenotype1.41846231
66MP0001672_abnormal_embryogenesis/_devel1.41846231
67MP0002086_abnormal_extraembryonic_tissu1.41787558
68MP0002084_abnormal_developmental_patter1.40708949
69MP0003077_abnormal_cell_cycle1.39374360
70MP0005621_abnormal_cell_physiology1.38599925
71MP0003303_peritoneal_inflammation1.37044812
72MP0008877_abnormal_DNA_methylation1.36049284
73MP0003984_embryonic_growth_retardation1.35856093
74MP0003656_abnormal_erythrocyte_physiolo1.35710992
75MP0003045_fibrosis1.34115169
76MP0003705_abnormal_hypodermis_morpholog1.33326900
77MP0001873_stomach_inflammation1.33258305
78MP0000383_abnormal_hair_follicle1.33073947
79MP0001661_extended_life_span1.31302100
80MP0003221_abnormal_cardiomyocyte_apopto1.30899954
81MP0002088_abnormal_embryonic_growth/wei1.30554087
82MP0003828_pulmonary_edema1.30386521
83MP0004808_abnormal_hematopoietic_stem1.29632747
84MP0001697_abnormal_embryo_size1.28606620
85MP0009333_abnormal_splenocyte_physiolog1.20714656
86MP0005174_abnormal_tail_pigmentation1.20654742
87MP0008007_abnormal_cellular_replicative1.20602654
88MP0005645_abnormal_hypothalamus_physiol1.20399160
89MP0005384_cellular_phenotype1.18681599
90MP0000579_abnormal_nail_morphology1.18090673
91MP0003183_abnormal_peptide_metabolism1.17370059
92MP0010155_abnormal_intestine_physiology1.17370000
93MP0000689_abnormal_spleen_morphology1.16984114
94MP0000350_abnormal_cell_proliferation1.16410241
95MP0004147_increased_porphyrin_level1.16110771
96MP0001545_abnormal_hematopoietic_system1.15298011
97MP0005397_hematopoietic_system_phenotyp1.15298011
98MP0009703_decreased_birth_body1.14698965
99MP0003453_abnormal_keratinocyte_physiol1.13398167
100MP0005023_abnormal_wound_healing1.12439997
101MP0003718_maternal_effect1.11873739
102MP0002796_impaired_skin_barrier1.10357359
103MP0002429_abnormal_blood_cell1.09851786
104MP0004215_abnormal_myocardial_fiber1.09246093
105MP0000372_irregular_coat_pigmentation1.08142514
106MP0001845_abnormal_inflammatory_respons1.07487306
107MP0006292_abnormal_olfactory_placode1.07373429
108MP0005623_abnormal_meninges_morphology1.06822219
109MP0002722_abnormal_immune_system1.06641595
110MP0005646_abnormal_pituitary_gland1.05661447
111MP0003448_altered_tumor_morphology1.00952505
112MP0003091_abnormal_cell_migration0.99700800
113MP0002332_abnormal_exercise_endurance0.99169781
114MP0002080_prenatal_lethality0.99090222
115MP0008775_abnormal_heart_ventricle0.97394013
116MP0004270_analgesia0.96247356
117MP0002972_abnormal_cardiac_muscle0.95865423
118MP0001533_abnormal_skeleton_physiology0.95156696
119MP0002998_abnormal_bone_remodeling0.94833344
120MP0005501_abnormal_skin_physiology0.93849698
121MP0005058_abnormal_lysosome_morphology0.93769151
122MP0002163_abnormal_gland_morphology0.92704193
123MP0004947_skin_inflammation0.92432736
124MP0002933_joint_inflammation0.92361069
125MP0000358_abnormal_cell_content/0.89521305
126MP0000703_abnormal_thymus_morphology0.89274036
127MP0002060_abnormal_skin_morphology0.89041788
128MP0004134_abnormal_chest_morphology0.88934745
129MP0005187_abnormal_penis_morphology0.88007702
130MP0004087_abnormal_muscle_fiber0.87703951
131MP0009764_decreased_sensitivity_to0.87004497
132MP0009672_abnormal_birth_weight0.86484233
133MP0000428_abnormal_craniofacial_morphol0.85176727
134MP0005367_renal/urinary_system_phenotyp0.84932902
135MP0000516_abnormal_urinary_system0.84932902
136MP0004197_abnormal_fetal_growth/weight/0.84368141
137MP0001879_abnormal_lymphatic_vessel0.82729374
138MP0002736_abnormal_nociception_after0.82409693
139MP0005409_darkened_coat_color0.80830689
140MP0002085_abnormal_embryonic_tissue0.80592015
141MP0002095_abnormal_skin_pigmentation0.79638541
142MP0001346_abnormal_lacrimal_gland0.79540725
143MP0001905_abnormal_dopamine_level0.79452512
144MP0000858_altered_metastatic_potential0.79216357
145MP0005076_abnormal_cell_differentiation0.78940751
146MP0001191_abnormal_skin_condition0.78858966
147MP0002734_abnormal_mechanical_nocicepti0.78765736
148MP0003693_abnormal_embryo_hatching0.78595021
149MP0002269_muscular_atrophy0.77317428
150MP0003950_abnormal_plasma_membrane0.76419370
151MP0010307_abnormal_tumor_latency0.76401699
152MP0001984_abnormal_olfaction0.76164269
153MP0003300_gastrointestinal_ulcer0.75949116
154MP0002128_abnormal_blood_circulation0.74777161
155MP0001784_abnormal_fluid_regulation0.73521332
156MP0010630_abnormal_cardiac_muscle0.72260544
157MP0010678_abnormal_skin_adnexa0.72184460
158MP0001501_abnormal_sleep_pattern0.71769516
159MP0002925_abnormal_cardiovascular_devel0.71654714
160MP0005395_other_phenotype0.71507912
161MP0002876_abnormal_thyroid_physiology0.71106236
162MP0001216_abnormal_epidermal_layer0.70388847
163MP0005620_abnormal_muscle_contractility0.70360710
164MP0000490_abnormal_crypts_of0.69449516
165MP0001968_abnormal_touch/_nociception0.69347874
166MP0000767_abnormal_smooth_muscle0.69166575
167MP0002928_abnormal_bile_duct0.68996354
168MP0002638_abnormal_pupillary_reflex0.68637796
169MP0006138_congestive_heart_failure0.67232757
170MP0005075_abnormal_melanosome_morpholog0.66446231
171MP0001486_abnormal_startle_reflex0.66154076
172MP0000266_abnormal_heart_morphology0.65633091
173MP0009780_abnormal_chondrocyte_physiolo0.65236461
174MP0002822_catalepsy0.64757597
175MP0005379_endocrine/exocrine_gland_phen0.64108760
176MP0005165_increased_susceptibility_to0.63962157
177MP0000313_abnormal_cell_death0.63609717
178MP0005390_skeleton_phenotype0.60943098
179MP0003866_abnormal_defecation0.59394861
180MP0003941_abnormal_skin_development0.57123874

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)6.40559558
2Abnormal platelet volume (HP:0011876)5.83921344
3Menorrhagia (HP:0000132)5.01095723
4Prostate neoplasm (HP:0100787)4.87650844
5Petechiae (HP:0000967)4.69037212
6Recurrent abscess formation (HP:0002722)4.03118623
7Recurrent bacterial skin infections (HP:0005406)3.69047205
8Gingival bleeding (HP:0000225)3.63223564
9Eczematoid dermatitis (HP:0000976)3.46896979
10Epistaxis (HP:0000421)3.24946824
11Febrile seizures (HP:0002373)3.13322628
12Chromsome breakage (HP:0040012)3.13216562
13Volvulus (HP:0002580)3.06333179
14Recurrent fungal infections (HP:0002841)3.04652756
15Abnormal hair whorl (HP:0010721)3.04446838
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.01907396
17Abnormality of the fingertips (HP:0001211)2.93281057
18Chronic mucocutaneous candidiasis (HP:0002728)2.92848369
19Recurrent cutaneous fungal infections (HP:0011370)2.92848369
20Abnormal platelet function (HP:0011869)2.83071087
21Impaired platelet aggregation (HP:0003540)2.83071087
22Tetraparesis (HP:0002273)2.77085919
23Transitional cell carcinoma of the bladder (HP:0006740)2.74529489
24Bladder neoplasm (HP:0009725)2.71032583
25Bladder carcinoma (HP:0002862)2.71032583
26Deep philtrum (HP:0002002)2.68632282
27Abnormal auditory evoked potentials (HP:0006958)2.68365015
28Purpura (HP:0000979)2.65985723
29Retrobulbar optic neuritis (HP:0100654)2.65970953
30Optic neuritis (HP:0100653)2.65970953
31Spontaneous hematomas (HP:0007420)2.65915043
32Abnormality of the prostate (HP:0008775)2.65284586
33Papillary thyroid carcinoma (HP:0002895)2.64583232
34Vasculitis (HP:0002633)2.64215824
35Neoplasm of the tracheobronchial system (HP:0100552)2.63379212
36Abnormality of the left ventricular outflow tract (HP:0011103)2.62792620
37Subaortic stenosis (HP:0001682)2.62792620
38Stomach cancer (HP:0012126)2.60240108
39Insidious onset (HP:0003587)2.59492067
40Termporal pattern (HP:0011008)2.59492067
41Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.59082198
42Biliary tract neoplasm (HP:0100574)2.56781360
43Lip pit (HP:0100267)2.56590778
44Chronic diarrhea (HP:0002028)2.55870611
45Leiomyosarcoma (HP:0100243)2.54939602
46Uterine leiomyosarcoma (HP:0002891)2.54939602
47Abnormality of the common coagulation pathway (HP:0010990)2.54140044
48Dyschromatopsia (HP:0007641)2.50569744
49Acanthocytosis (HP:0001927)2.49573289
50Shoulder girdle muscle weakness (HP:0003547)2.49267497
51Recurrent viral infections (HP:0004429)2.48782587
52Thyroiditis (HP:0100646)2.48106986
53Recurrent skin infections (HP:0001581)2.47221302
54Fair hair (HP:0002286)2.47000942
55IgM deficiency (HP:0002850)2.43807821
56Ankyloglossia (HP:0010296)2.43061249
57Mediastinal lymphadenopathy (HP:0100721)2.41679319
58Short middle phalanx of the 5th finger (HP:0004220)2.39663044
59Pelvic girdle muscle weakness (HP:0003749)2.36219435
60Rhabdomyosarcoma (HP:0002859)2.35517193
61Abnormality of the musculature of the pelvis (HP:0001469)2.34309119
62Abnormality of the hip-girdle musculature (HP:0001445)2.34309119
63Obstructive lung disease (HP:0006536)2.34203434
64Chronic obstructive pulmonary disease (HP:0006510)2.34203434
65Acute myeloid leukemia (HP:0004808)2.33043602
66Stomatitis (HP:0010280)2.28099520
67Myositis (HP:0100614)2.28008603
68Autoamputation (HP:0001218)2.27381489
69Upper limb muscle weakness (HP:0003484)2.27070342
70Recurrent pneumonia (HP:0006532)2.24943351
71Abnormality of the nasal septum (HP:0000419)2.24216027
72Focal motor seizures (HP:0011153)2.23531613
73Conjunctival telangiectasia (HP:0000524)2.21848721
74Malignant gastrointestinal tract tumors (HP:0006749)2.21800166
75Gastrointestinal carcinoma (HP:0002672)2.21800166
76Type 2 muscle fiber atrophy (HP:0003554)2.21544649
77Pustule (HP:0200039)2.21276790
78Cortical dysplasia (HP:0002539)2.18912003
79Subacute progressive viral hepatitis (HP:0006572)2.16186329
80Generalized hypopigmentation of hair (HP:0011358)2.15488589
81Increased IgM level (HP:0003496)2.14951523
82Curly hair (HP:0002212)2.14644073
83Neoplasm of the small intestine (HP:0100833)2.11881376
84Spinal cord lesions (HP:0100561)2.11658180
85Syringomyelia (HP:0003396)2.11658180
86Hypoplastic labia majora (HP:0000059)2.10806162
87Osteolytic defects of the phalanges of the hand (HP:0009771)2.10281625
88Osteolytic defects of the hand bones (HP:0009699)2.10281625
89Eosinophilia (HP:0001880)2.09775581
90Embryonal renal neoplasm (HP:0011794)2.09629247
91Fetal akinesia sequence (HP:0001989)2.08068109
92Abnormal delayed hypersensitivity skin test (HP:0002963)2.07427292
93Increased density of long bones (HP:0006392)2.07292180
94Submucous cleft hard palate (HP:0000176)2.05398154
95Abnormality of the labia majora (HP:0012881)2.04354351
96Poikilocytosis (HP:0004447)2.03232973
97Protruding tongue (HP:0010808)2.02425008
98Relative macrocephaly (HP:0004482)2.01308229
99Gastrointestinal stroma tumor (HP:0100723)2.00930647
100Alveolar cell carcinoma (HP:0006519)2.00849461
101Gingivitis (HP:0000230)2.00768264
102Anhidrosis (HP:0000970)2.00506948
103Inflammation of the large intestine (HP:0002037)2.00505387
104Panhypogammaglobulinemia (HP:0003139)2.00126287
105Abnormality of T cell number (HP:0011839)1.99027452
106Hematochezia (HP:0002573)1.97229546
107Granulocytopenia (HP:0001913)1.97087241
108Rimmed vacuoles (HP:0003805)1.96980476
109Orchitis (HP:0100796)1.95971713
110T lymphocytopenia (HP:0005403)1.95894490
111Absent frontal sinuses (HP:0002688)1.94109657
112Abnormality of chromosome stability (HP:0003220)1.93968067
113Agammaglobulinemia (HP:0004432)1.93919424
114Abnormality of oral frenula (HP:0000190)1.93131362
115Lymphopenia (HP:0001888)1.93113605
116Inappropriate behavior (HP:0000719)1.92939156
117Leukocytosis (HP:0001974)1.92720082
118IgA deficiency (HP:0002720)1.90770237
119Neonatal hypoglycemia (HP:0001998)1.89697710
120Nemaline bodies (HP:0003798)1.88616236
121Large earlobe (HP:0009748)1.88408582
122Abnormality of eosinophils (HP:0001879)1.88146172
123Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.88125732
124Thyroid carcinoma (HP:0002890)1.87956549
125Colitis (HP:0002583)1.87839338
126Long clavicles (HP:0000890)1.87727020
127Fatigue (HP:0012378)1.87362225
128Atonic seizures (HP:0010819)1.87105960
129Nephroblastoma (Wilms tumor) (HP:0002667)1.86946691
130Muscle fiber atrophy (HP:0100295)1.86284304
131Gonadotropin excess (HP:0000837)1.86282565
132Fatigable weakness (HP:0003473)1.86219123
133Abnormality of the neuromuscular junction (HP:0003398)1.86219123
134Neoplasm of the rectum (HP:0100743)1.85474993
135Meningitis (HP:0001287)1.83832517
136Pulmonary infiltrates (HP:0002113)1.83724160
137Autoimmune thrombocytopenia (HP:0001973)1.83248061
138Abnormality of B cell number (HP:0010975)1.83100230
139B lymphocytopenia (HP:0010976)1.83100230
140Aplasia of the musculature (HP:0100854)1.82736065
141Medulloblastoma (HP:0002885)1.82608480
142Abnormality of the vasculature of the conjunctiva (HP:0008054)1.81756859
143Abnormality of the corticospinal tract (HP:0002492)1.81137959
144Recurrent lower respiratory tract infections (HP:0002783)1.80192252
145Agnosia (HP:0010524)1.80045026
146Prolonged bleeding time (HP:0003010)1.77409172
147Amaurosis fugax (HP:0100576)1.77310513
148Urethral obstruction (HP:0000796)1.77305925
149Distal lower limb amyotrophy (HP:0008944)1.77022941
150Hypothermia (HP:0002045)1.76939567
151Premature rupture of membranes (HP:0001788)1.76117223
152Amyotrophic lateral sclerosis (HP:0007354)1.76069937
153IgG deficiency (HP:0004315)1.75765580
154Weak cry (HP:0001612)1.75348130
155Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.75229313
156Elevated erythrocyte sedimentation rate (HP:0003565)1.74154453
157Abnormality of macrophages (HP:0004311)1.73851438
158Abnormal biliary tract morphology (HP:0012440)1.72930613
159Myocardial infarction (HP:0001658)1.72787307
160Osteomyelitis (HP:0002754)1.72380598
161Bruising susceptibility (HP:0000978)1.72363664
162Clubbing of toes (HP:0100760)1.72288333
163Uterine neoplasm (HP:0010784)1.71644229
164Abnormality of cells of the lymphoid lineage (HP:0012140)1.71468081
165Overgrowth (HP:0001548)1.71085356
166Xerostomia (HP:0000217)1.71009374
167Spondylolisthesis (HP:0003302)1.70613718
168Abnormality of the lower motor neuron (HP:0002366)1.70051593
169Cystic hygroma (HP:0000476)1.69572537
170Areflexia of lower limbs (HP:0002522)1.69098702
171Distal arthrogryposis (HP:0005684)1.68126558
172Periodontitis (HP:0000704)1.67508995
173Arterial tortuosity (HP:0005116)1.66844609
174Distal lower limb muscle weakness (HP:0009053)1.66613841
175Abnormality of incisor morphology (HP:0011063)1.64891335
176Muscle fiber inclusion bodies (HP:0100299)1.64819976
177Restrictive lung disease (HP:0002091)1.64391478
178Lower limb amyotrophy (HP:0007210)1.63443328
179Ectopic kidney (HP:0000086)1.62843164
180Neoplasm of the thyroid gland (HP:0100031)1.61471653
181Myelodysplasia (HP:0002863)1.60710701
182Oligodactyly (hands) (HP:0001180)1.60647794
183Macroorchidism (HP:0000053)1.60572116
184Complete atrioventricular canal defect (HP:0001674)1.60385849
185Renal cell carcinoma (HP:0005584)1.59974992
186Calcaneovalgus deformity (HP:0001848)1.59740303
187Atrophic scars (HP:0001075)1.59504815
188Degeneration of the lateral corticospinal tracts (HP:0002314)1.59303976

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.86880586
2IRAK33.16086986
3MAP3K143.13916278
4ACVR1B2.73021760
5TRIM282.52122124
6RIPK42.43605420
7PDK22.41925462
8STK242.41563425
9IRAK42.32905903
10TNIK2.28954877
11CDK122.18289836
12JAK32.10820013
13MAP4K12.09645989
14BRSK22.06086681
15EIF2AK12.05077484
16EIF2AK31.92483572
17MYLK1.91798093
18CASK1.88145989
19BMX1.87391115
20ZAK1.70061726
21TYK21.69772981
22JAK11.69368410
23PBK1.64872974
24GRK71.63541572
25NEK61.60639611
26IKBKE1.54299751
27TAOK31.52519419
28PNCK1.52221561
29MET1.51970979
30PIK3CG1.51918847
31FRK1.51486640
32STK38L1.50838328
33SGK21.50789587
34BRD41.46524621
35ADRBK21.44637778
36MST41.44186112
37MST1R1.40062985
38TRPM71.32164060
39IKBKB1.29863406
40SCYL21.27586342
41STK31.26106888
42KSR11.25584003
43TTK1.25143177
44EIF2AK21.24863241
45PLK31.22523019
46PRPF4B1.19434510
47CDK31.19255256
48INSRR1.18057918
49TEC1.16636370
50TGFBR21.16255065
51NEK91.14316195
52HCK1.14222161
53GRK51.13349315
54SRPK11.11498213
55MARK31.10998518
56MKNK11.09117006
57SYK1.08946289
58YES11.07812042
59PLK21.07229406
60BMPR21.05946501
61ITK1.05512127
62MAP3K21.03524854
63LCK1.03177125
64NEK10.96795187
65BMPR1B0.96357661
66KIT0.95231207
67PDGFRB0.94296786
68CHUK0.94065686
69SGK30.93994444
70SIK30.93507159
71MAP3K50.92882821
72CDK90.92320677
73FGR0.90456283
74CAMK1D0.89917240
75TBK10.89441884
76PTK2B0.89093902
77MUSK0.88208513
78PDGFRA0.87941563
79SGK2230.87933802
80SGK4940.87933802
81RAF10.87298439
82VRK10.85096508
83LYN0.83910599
84MAP3K130.83637246
85PAK40.81408829
86CDK60.80818473
87FES0.79730213
88MKNK20.79180684
89PIK3CA0.76952082
90HIPK20.76798763
91CSK0.75326891
92MAP3K90.75078592
93CLK10.73908711
94ZAP700.73831322
95NUAK10.73489412
96PKN10.72152485
97PRKAA20.71861111
98BTK0.71016041
99PRKCQ0.70136061
100SGK10.69987775
101DMPK0.69914145
102KSR20.68982493
103FGFR30.66761927
104MAPKAPK50.66596663
105TNK20.65678066
106MAPK130.65647178
107OBSCN0.64438545
108LATS10.63676252
109PTK20.63609228
110NLK0.61710636
111CSF1R0.61057465
112PIM10.60779401
113CAMK1G0.60312093
114WNK10.59989101
115BRAF0.58370989
116RPS6KA40.57233736
117LMTK20.56294570
118TTN0.55438675
119FER0.55249925
120ILK0.54972896
121MAP3K120.54844970
122MAP3K40.53433371
123MAPK70.53309717
124BCR0.52950769
125AKT30.50499848
126STK160.49675863
127LATS20.49515486
128PRKCE0.49287404
129BLK0.49152240
130CHEK10.49086448
131STK100.49077347
132MAP2K70.48666029
133JAK20.48645003
134NTRK30.48530665
135STK380.47837680
136MELK0.47708714
137CAMKK20.47436715
138FGFR10.46907984
139ATM0.46782207
140RET0.46516758
141ABL10.46102235
142ERBB30.46022379
143ERBB40.45356036
144MOS0.45336549
145CSNK1G10.45119163
146SIK20.44308112
147EPHB10.44197665
148STK40.44153865
149PLK40.43232035
150CDC70.42628686
151MAPK100.41739021
152STK390.38248637
153MAP3K60.37743052
154PAK10.36858280

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.81991821
2Mismatch repair_Homo sapiens_hsa034302.39852583
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.02824502
4Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.02593037
5Primary immunodeficiency_Homo sapiens_hsa053401.94312170
6Cell cycle_Homo sapiens_hsa041101.93592020
7Thyroid cancer_Homo sapiens_hsa052161.92873841
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.81800291
9Intestinal immune network for IgA production_Homo sapiens_hsa046721.81132048
10Leishmaniasis_Homo sapiens_hsa051401.79542004
11Hematopoietic cell lineage_Homo sapiens_hsa046401.70331296
12Allograft rejection_Homo sapiens_hsa053301.64607749
13ECM-receptor interaction_Homo sapiens_hsa045121.63760287
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63607119
15Focal adhesion_Homo sapiens_hsa045101.61372187
16Osteoclast differentiation_Homo sapiens_hsa043801.60431403
17Endometrial cancer_Homo sapiens_hsa052131.56402359
18Measles_Homo sapiens_hsa051621.55747532
19Renal cell carcinoma_Homo sapiens_hsa052111.55541887
20Rheumatoid arthritis_Homo sapiens_hsa053231.47039883
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.46175943
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.45848074
23Chemokine signaling pathway_Homo sapiens_hsa040621.43075046
24Small cell lung cancer_Homo sapiens_hsa052221.42888480
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41771644
26B cell receptor signaling pathway_Homo sapiens_hsa046621.41006259
27Proteoglycans in cancer_Homo sapiens_hsa052051.37313638
28Steroid biosynthesis_Homo sapiens_hsa001001.36907943
29Graft-versus-host disease_Homo sapiens_hsa053321.35915687
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32890364
31Non-small cell lung cancer_Homo sapiens_hsa052231.32472330
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28867890
33Oocyte meiosis_Homo sapiens_hsa041141.28230812
34Colorectal cancer_Homo sapiens_hsa052101.27462099
35Malaria_Homo sapiens_hsa051441.27454212
36T cell receptor signaling pathway_Homo sapiens_hsa046601.26027143
37TGF-beta signaling pathway_Homo sapiens_hsa043501.23673559
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22020131
39TNF signaling pathway_Homo sapiens_hsa046681.21809152
40Gap junction_Homo sapiens_hsa045401.21384752
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21223015
42Asthma_Homo sapiens_hsa053101.20380185
43Autoimmune thyroid disease_Homo sapiens_hsa053201.19974976
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18947290
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18356910
46Influenza A_Homo sapiens_hsa051641.17533753
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17373956
48Tuberculosis_Homo sapiens_hsa051521.16948581
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16906149
50Pertussis_Homo sapiens_hsa051331.12042431
51RNA transport_Homo sapiens_hsa030131.11350731
52Glioma_Homo sapiens_hsa052141.10782083
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10636060
54African trypanosomiasis_Homo sapiens_hsa051431.10572863
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10221070
56Herpes simplex infection_Homo sapiens_hsa051681.08598826
57Jak-STAT signaling pathway_Homo sapiens_hsa046301.07255765
58Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06030206
59Salmonella infection_Homo sapiens_hsa051321.05011469
60Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04230824
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03605250
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03212471
63Amoebiasis_Homo sapiens_hsa051461.03142414
64Viral carcinogenesis_Homo sapiens_hsa052031.02697728
65Toxoplasmosis_Homo sapiens_hsa051451.02169194
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01904849
67Hepatitis B_Homo sapiens_hsa051610.99272366
68Olfactory transduction_Homo sapiens_hsa047400.99232457
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93911348
70Melanoma_Homo sapiens_hsa052180.92276227
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90531847
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90028962
73Long-term potentiation_Homo sapiens_hsa047200.87392595
74Phagosome_Homo sapiens_hsa041450.87036086
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.86204723
76Dorso-ventral axis formation_Homo sapiens_hsa043200.86151007
77Pancreatic cancer_Homo sapiens_hsa052120.86073027
78Type I diabetes mellitus_Homo sapiens_hsa049400.85783991
79Tight junction_Homo sapiens_hsa045300.85555949
80Morphine addiction_Homo sapiens_hsa050320.85124667
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84761593
82Inositol phosphate metabolism_Homo sapiens_hsa005620.84755443
83Viral myocarditis_Homo sapiens_hsa054160.82526106
84mTOR signaling pathway_Homo sapiens_hsa041500.82106058
85Serotonergic synapse_Homo sapiens_hsa047260.81994674
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81952248
87Platelet activation_Homo sapiens_hsa046110.80788683
88FoxO signaling pathway_Homo sapiens_hsa040680.80310718
89MAPK signaling pathway_Homo sapiens_hsa040100.77457585
90Insulin signaling pathway_Homo sapiens_hsa049100.77282959
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76940144
92p53 signaling pathway_Homo sapiens_hsa041150.75706439
93Antigen processing and presentation_Homo sapiens_hsa046120.75699082
94Shigellosis_Homo sapiens_hsa051310.75532075
95Hepatitis C_Homo sapiens_hsa051600.75093505
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.74523786
97Sphingolipid metabolism_Homo sapiens_hsa006000.74440689
98Legionellosis_Homo sapiens_hsa051340.74049628
99Dilated cardiomyopathy_Homo sapiens_hsa054140.74030140
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73329179
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.73198653
102Choline metabolism in cancer_Homo sapiens_hsa052310.72790585
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72781131
104Fanconi anemia pathway_Homo sapiens_hsa034600.72778108
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72562953
106Nucleotide excision repair_Homo sapiens_hsa034200.72066987
107Cholinergic synapse_Homo sapiens_hsa047250.71563222
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71055876
109Rap1 signaling pathway_Homo sapiens_hsa040150.70902286
110GnRH signaling pathway_Homo sapiens_hsa049120.70009630
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69416056
112Circadian rhythm_Homo sapiens_hsa047100.68439784
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67213527
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66680069
115Long-term depression_Homo sapiens_hsa047300.66632854
116Apoptosis_Homo sapiens_hsa042100.66092104
117Pathways in cancer_Homo sapiens_hsa052000.65805115
118Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65272773
119HIF-1 signaling pathway_Homo sapiens_hsa040660.65001319
120Non-homologous end-joining_Homo sapiens_hsa034500.64709019
121Chronic myeloid leukemia_Homo sapiens_hsa052200.64166141
122ErbB signaling pathway_Homo sapiens_hsa040120.64033003
123Nicotine addiction_Homo sapiens_hsa050330.63626675
124Prolactin signaling pathway_Homo sapiens_hsa049170.62133024
125mRNA surveillance pathway_Homo sapiens_hsa030150.61680343
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61432867
127Collecting duct acid secretion_Homo sapiens_hsa049660.61243010
128Circadian entrainment_Homo sapiens_hsa047130.61242804
129Wnt signaling pathway_Homo sapiens_hsa043100.61161842
130Glucagon signaling pathway_Homo sapiens_hsa049220.60998315
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60923816
132cAMP signaling pathway_Homo sapiens_hsa040240.59874141
133Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59159095
134Epstein-Barr virus infection_Homo sapiens_hsa051690.58914618
135Pentose phosphate pathway_Homo sapiens_hsa000300.58641359
136Selenocompound metabolism_Homo sapiens_hsa004500.58556413
137Calcium signaling pathway_Homo sapiens_hsa040200.58462594
138Oxytocin signaling pathway_Homo sapiens_hsa049210.58351976
139Basal transcription factors_Homo sapiens_hsa030220.58152807
140Staphylococcus aureus infection_Homo sapiens_hsa051500.57905423
141Regulation of autophagy_Homo sapiens_hsa041400.57807017
142Prostate cancer_Homo sapiens_hsa052150.57716352
143Adherens junction_Homo sapiens_hsa045200.57231631
144Phospholipase D signaling pathway_Homo sapiens_hsa040720.56958189
145Ras signaling pathway_Homo sapiens_hsa040140.56304874
146Hippo signaling pathway_Homo sapiens_hsa043900.56234457
147Type II diabetes mellitus_Homo sapiens_hsa049300.56208632
148Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56171307
149Lysosome_Homo sapiens_hsa041420.56090670
150Glutamatergic synapse_Homo sapiens_hsa047240.55356722
151Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54983947
152Neurotrophin signaling pathway_Homo sapiens_hsa047220.54600304
153Acute myeloid leukemia_Homo sapiens_hsa052210.53760171
154Ether lipid metabolism_Homo sapiens_hsa005650.53739186
155Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53692668
156MicroRNAs in cancer_Homo sapiens_hsa052060.51924605
157Fatty acid elongation_Homo sapiens_hsa000620.49981707
158Endocytosis_Homo sapiens_hsa041440.49920229
159Other glycan degradation_Homo sapiens_hsa005110.49864468
160Bladder cancer_Homo sapiens_hsa052190.47156104
161Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46296976

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »