ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of mitochondrial fission (GO:0090141)	6.11438556
2	pyrimidine nucleobase catabolic process (GO:0006208)	5.04028622
3	protein-cofactor linkage (GO:0018065)	5.00106627
4	peptidyl-histidine modification (GO:0018202)	4.78235052
5	negative regulation of oligodendrocyte differentiation (GO:0048715)	4.47365561
6	regulation of mitochondrial fission (GO:0090140)	4.43106818
7	L-serine metabolic process (GO:0006563)	4.40210792
8	nonmotile primary cilium assembly (GO:0035058)	4.22391468
9	nucleobase catabolic process (GO:0046113)	4.01732656
10	DNA damage response, detection of DNA damage (GO:0042769)	3.91543848
11	iron-sulfur cluster assembly (GO:0016226)	3.87212961
12	metallo-sulfur cluster assembly (GO:0031163)	3.87212961
13	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.76688887
14	sequestering of actin monomers (GO:0042989)	3.72713058
15	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.72296553
16	protein K6-linked ubiquitination (GO:0085020)	3.71251555
17	cholesterol biosynthetic process (GO:0006695)	3.61605894
18	neuron cell-cell adhesion (GO:0007158)	3.58153157
19	cell fate commitment involved in formation of primary germ layer (GO:0060795)	3.57707930
20	olfactory bulb development (GO:0021772)	3.54663035
21	regulation of oligodendrocyte differentiation (GO:0048713)	3.51896516
22	brain morphogenesis (GO:0048854)	3.50116348
23	cysteine metabolic process (GO:0006534)	3.44179332
24	gamma-aminobutyric acid transport (GO:0015812)	3.43064493
25	isoprenoid biosynthetic process (GO:0008299)	3.33199092
26	forebrain neuron differentiation (GO:0021879)	3.32238017
27	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.30083639
28	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.30083639
29	retinal cone cell development (GO:0046549)	3.29444992
30	response to pheromone (GO:0019236)	3.26550758
31	branched-chain amino acid catabolic process (GO:0009083)	3.25863014
32	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-	3.24005707
33	mannosylation (GO:0097502)	3.23770768
34	heart trabecula morphogenesis (GO:0061384)	3.23489317
35	presynaptic membrane assembly (GO:0097105)	3.23042745
36	vocalization behavior (GO:0071625)	3.21499620
37	regulation of cilium movement (GO:0003352)	3.20940079
38	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.17501970
39	protein localization to cilium (GO:0061512)	3.16393903
40	sterol biosynthetic process (GO:0016126)	3.10560429
41	estrogen biosynthetic process (GO:0006703)	3.06801016
42	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.06292674
43	NADH dehydrogenase complex assembly (GO:0010257)	3.06292674
44	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.06292674
45	ubiquinone metabolic process (GO:0006743)	3.06122426
46	regulation of mitochondrial translation (GO:0070129)	3.04882560
47	regulation of development, heterochronic (GO:0040034)	3.04072689
48	transmission of nerve impulse (GO:0019226)	3.01367566
49	neural tube formation (GO:0001841)	3.00116079
50	DNA double-strand break processing (GO:0000729)	2.97296358
51	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.96341727
52	blood vessel maturation (GO:0001955)	2.94969683
53	establishment of mitochondrion localization (GO:0051654)	2.91301568
54	membrane budding (GO:0006900)	2.86228311
55	regulation of feeding behavior (GO:0060259)	2.82172631
56	cellular response to leptin stimulus (GO:0044320)	2.81339585
57	ubiquinone biosynthetic process (GO:0006744)	2.80767944
58	protein insertion into membrane (GO:0051205)	2.79095849
59	forebrain morphogenesis (GO:0048853)	2.78898210
60	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.78035834
61	synapse assembly (GO:0007416)	2.76342224
62	hippocampus development (GO:0021766)	2.76212613
63	serine family amino acid catabolic process (GO:0009071)	2.74316134
64	establishment of integrated proviral latency (GO:0075713)	2.73154804
65	DNA integration (GO:0015074)	2.71687878
66	base-excision repair, AP site formation (GO:0006285)	2.71351666
67	layer formation in cerebral cortex (GO:0021819)	2.70169442
68	negative regulation of glial cell differentiation (GO:0045686)	2.69246534
69	axoneme assembly (GO:0035082)	2.68913826
70	photoreceptor cell development (GO:0042461)	2.68207502
71	serine family amino acid biosynthetic process (GO:0009070)	2.68162720
72	de novo posttranslational protein folding (GO:0051084)	2.65690143
73	protein complex biogenesis (GO:0070271)	2.65582350
74	mitochondrial fission (GO:0000266)	2.65093915
75	cilium morphogenesis (GO:0060271)	2.64602439
76	positive regulation of TOR signaling (GO:0032008)	2.64400242
77	C4-dicarboxylate transport (GO:0015740)	2.63582130
78	protein polyglutamylation (GO:0018095)	2.62381580
79	behavioral response to nicotine (GO:0035095)	2.62298597
80	synaptic vesicle endocytosis (GO:0048488)	2.60553199
81	succinate metabolic process (GO:0006105)	2.58610584
82	eye photoreceptor cell development (GO:0042462)	2.57071583
83	histone H2A acetylation (GO:0043968)	2.55492550
84	positive regulation of amino acid transport (GO:0051957)	2.54874161
85	DNA ligation (GO:0006266)	2.54269562
86	glial cell proliferation (GO:0014009)	2.54226912
87	intraciliary transport (GO:0042073)	2.54166608
88	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.54033352
89	de novo protein folding (GO:0006458)	2.53048254
90	peroxisome organization (GO:0007031)	2.52859362
91	presynaptic membrane organization (GO:0097090)	2.51644934
92	preassembly of GPI anchor in ER membrane (GO:0016254)	2.50219171
93	establishment of melanosome localization (GO:0032401)	2.49060468
94	sulfur amino acid catabolic process (GO:0000098)	2.47020936
95	melanosome localization (GO:0032400)	2.46584459
96	mitochondrial respiratory chain complex assembly (GO:0033108)	2.46304156
97	4-hydroxyproline metabolic process (GO:0019471)	2.45085724
98	establishment of viral latency (GO:0019043)	2.44752613
99	cell migration in hindbrain (GO:0021535)	2.43710855
100	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.42711929

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.06642891
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.89211477
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.22865732
4	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.15090642
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.07999662
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.02160988
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.74623976
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.58817567
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.55623967
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.52122270
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.48454252
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.45438868
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.36250153
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.33388205
15	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.30426360
16	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.29161577
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.26765258
18	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.25480693
19	VDR_23849224_ChIP-Seq_CD4+_Human	2.19675186
20	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.17716523
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.03918222
22	VDR_22108803_ChIP-Seq_LS180_Human	2.02857034
23	GBX2_23144817_ChIP-Seq_PC3_Human	2.00087519
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.99849015
25	GABP_19822575_ChIP-Seq_HepG2_Human	1.96750231
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.93130805
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.92899260
28	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.90038355
29	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.85952832
30	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.82380337
31	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.81755279
32	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.79975093
33	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.76923394
34	EWS_26573619_Chip-Seq_HEK293_Human	1.74766658
35	FUS_26573619_Chip-Seq_HEK293_Human	1.74407810
36	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.72592851
37	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.71530961
38	DCP1A_22483619_ChIP-Seq_HELA_Human	1.71199699
39	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.71095611
40	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.70572662
41	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.68317747
42	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.64525190
43	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.62206465
44	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.59688749
45	TAF15_26573619_Chip-Seq_HEK293_Human	1.57559913
46	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.54771640
47	XRN2_22483619_ChIP-Seq_HELA_Human	1.49253787
48	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.48790591
49	FOXP3_21729870_ChIP-Seq_TREG_Human	1.48600590
50	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.47869624
51	TTF2_22483619_ChIP-Seq_HELA_Human	1.47434976
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.46420115
53	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.45111376
54	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.44857551
55	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.44319326
56	TP53_22573176_ChIP-Seq_HFKS_Human	1.43474586
57	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.42872622
58	EZH2_22144423_ChIP-Seq_EOC_Human	1.38967460
59	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.38853155
60	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.38739398
61	P300_19829295_ChIP-Seq_ESCs_Human	1.37135186
62	HTT_18923047_ChIP-ChIP_STHdh_Human	1.34515958
63	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.30287878
64	RNF2_27304074_Chip-Seq_NSC_Mouse	1.29333793
65	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29118313
66	CBP_20019798_ChIP-Seq_JUKART_Human	1.28947312
67	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.28947312
68	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.26679836
69	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.25124840
70	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.24202913
71	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.21550934
72	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.16213016
73	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.14986787
74	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.13356753
75	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.08163894
76	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.05677033
77	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.05433386
78	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.04970814
79	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.00190289
80	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99934280
81	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.99423675
82	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98425823
83	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.98324823
84	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96856517
85	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.95901568
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.94522172
87	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.93415281
88	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.89457934
89	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.89252852
90	ER_23166858_ChIP-Seq_MCF-7_Human	0.89055165
91	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.88606044
92	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.88123758
93	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.86933496
94	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.85347797
95	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.84322333
96	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.84216037
97	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.82846687
98	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.79620348
99	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.78959884
100	CIITA_25753668_ChIP-Seq_RAJI_Human	0.78955090

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.46883930
2	MP0005394_taste/olfaction_phenotype	3.77945290
3	MP0005499_abnormal_olfactory_system	3.77945290
4	MP0003136_yellow_coat_color	3.76274213
5	MP0008789_abnormal_olfactory_epithelium	3.47538662
6	MP0003880_abnormal_central_pattern	3.42840048
7	MP0001984_abnormal_olfaction	3.08890671
8	MP0004270_analgesia	2.93663537
9	MP0003011_delayed_dark_adaptation	2.86937470
10	MP0002102_abnormal_ear_morphology	2.51645279
11	MP0001529_abnormal_vocalization	2.40846013
12	MP0002277_abnormal_respiratory_mucosa	2.12233112
13	MP0000049_abnormal_middle_ear	1.97616155
14	MP0008877_abnormal_DNA_methylation	1.97337145
15	MP0003221_abnormal_cardiomyocyte_apopto	1.89938713
16	MP0001293_anophthalmia	1.89104552
17	MP0000631_abnormal_neuroendocrine_gland	1.81523992
18	MP0002736_abnormal_nociception_after	1.80580560
19	MP0001764_abnormal_homeostasis	1.76365705
20	MP0003567_abnormal_fetal_cardiomyocyte	1.75244374
21	MP0006276_abnormal_autonomic_nervous	1.70774881
22	MP0000647_abnormal_sebaceous_gland	1.68664745
23	MP0003122_maternal_imprinting	1.64788713
24	MP0005646_abnormal_pituitary_gland	1.59779438
25	MP0006054_spinal_hemorrhage	1.58458267
26	MP0000778_abnormal_nervous_system	1.55616135
27	MP0005253_abnormal_eye_physiology	1.54433102
28	MP0003938_abnormal_ear_development	1.52107709
29	MP0002653_abnormal_ependyma_morphology	1.48025348
30	MP0001270_distended_abdomen	1.46951329
31	MP0004147_increased_porphyrin_level	1.46869986
32	MP0005187_abnormal_penis_morphology	1.37348212
33	MP0006072_abnormal_retinal_apoptosis	1.32957461
34	MP0003937_abnormal_limbs/digits/tail_de	1.30174824
35	MP0005645_abnormal_hypothalamus_physiol	1.29942870
36	MP0000372_irregular_coat_pigmentation	1.27920102
37	MP0001286_abnormal_eye_development	1.27065648
38	MP0002233_abnormal_nose_morphology	1.24591971
39	MP0008058_abnormal_DNA_repair	1.23974649
40	MP0002697_abnormal_eye_size	1.22303795
41	MP0005248_abnormal_Harderian_gland	1.21873098
42	MP0003635_abnormal_synaptic_transmissio	1.19601481
43	MP0001968_abnormal_touch/_nociception	1.19330540
44	MP0001986_abnormal_taste_sensitivity	1.18058705
45	MP0004859_abnormal_synaptic_plasticity	1.15635510
46	MP0002234_abnormal_pharynx_morphology	1.15587444
47	MP0002572_abnormal_emotion/affect_behav	1.14393677
48	MP0002751_abnormal_autonomic_nervous	1.12458559
49	MP0003137_abnormal_impulse_conducting	1.12333820
50	MP0005551_abnormal_eye_electrophysiolog	1.12112033
51	MP0005391_vision/eye_phenotype	1.09904618
52	MP0002090_abnormal_vision	1.08613071
53	MP0002837_dystrophic_cardiac_calcinosis	1.08438461
54	MP0001177_atelectasis	1.06435636
55	MP0002734_abnormal_mechanical_nocicepti	1.05693660
56	MP0005423_abnormal_somatic_nervous	1.04548453
57	MP0002063_abnormal_learning/memory/cond	1.03351707
58	MP0006035_abnormal_mitochondrial_morpho	1.02627730
59	MP0002557_abnormal_social/conspecific_i	1.02518048
60	MP0003693_abnormal_embryo_hatching	1.01616528
61	MP0002127_abnormal_cardiovascular_syste	1.01616214
62	MP0002249_abnormal_larynx_morphology	1.00915398
63	MP0003121_genomic_imprinting	0.98580742
64	MP0002752_abnormal_somatic_nervous	0.97735166
65	MP0008995_early_reproductive_senescence	0.97151379
66	MP0000639_abnormal_adrenal_gland	0.95259083
67	MP0004811_abnormal_neuron_physiology	0.94154016
68	MP0003755_abnormal_palate_morphology	0.94064692
69	MP0008932_abnormal_embryonic_tissue	0.91911251
70	MP0009745_abnormal_behavioral_response	0.91355209
71	MP0003787_abnormal_imprinting	0.90998119
72	MP0005083_abnormal_biliary_tract	0.90911054
73	MP0009046_muscle_twitch	0.90396711
74	MP0001188_hyperpigmentation	0.89447026
75	MP0010094_abnormal_chromosome_stability	0.88190354
76	MP0002272_abnormal_nervous_system	0.87891584
77	MP0002638_abnormal_pupillary_reflex	0.87641648
78	MP0002092_abnormal_eye_morphology	0.86883018
79	MP0003861_abnormal_nervous_system	0.84604329
80	MP0002184_abnormal_innervation	0.83739898
81	MP0004142_abnormal_muscle_tone	0.83530173
82	MP0002882_abnormal_neuron_morphology	0.82112664
83	MP0000751_myopathy	0.78001877
84	MP0002152_abnormal_brain_morphology	0.77285791
85	MP0005410_abnormal_fertilization	0.76803230
86	MP0000358_abnormal_cell_content/	0.75656692
87	MP0000026_abnormal_inner_ear	0.75649784
88	MP0003186_abnormal_redox_activity	0.74356170
89	MP0002069_abnormal_eating/drinking_beha	0.73123767
90	MP0001486_abnormal_startle_reflex	0.71438034
91	MP0000955_abnormal_spinal_cord	0.71159475
92	MP0003111_abnormal_nucleus_morphology	0.70914495
93	MP0005195_abnormal_posterior_eye	0.70000781
94	MP0010386_abnormal_urinary_bladder	0.69830943
95	MP0002822_catalepsy	0.69438430
96	MP0005084_abnormal_gallbladder_morpholo	0.68434740
97	MP0003698_abnormal_male_reproductive	0.67229451
98	MP0002210_abnormal_sex_determination	0.66021183
99	MP0004957_abnormal_blastocyst_morpholog	0.64744318
100	MP0001929_abnormal_gametogenesis	0.63388564

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Retinal dysplasia (HP:0007973)	5.04048622
2	Split foot (HP:0001839)	4.23084677
3	Congenital primary aphakia (HP:0007707)	4.22160598
4	Gait imbalance (HP:0002141)	4.20291377
5	Nephrogenic diabetes insipidus (HP:0009806)	4.15086355
6	Medial flaring of the eyebrow (HP:0010747)	4.14821112
7	Optic nerve hypoplasia (HP:0000609)	3.93729659
8	Septo-optic dysplasia (HP:0100842)	3.83064523
9	Lissencephaly (HP:0001339)	3.75868767
10	Type II lissencephaly (HP:0007260)	3.49647763
11	Hyperglycinemia (HP:0002154)	3.47981975
12	Vaginal atresia (HP:0000148)	3.46284261
13	Genital tract atresia (HP:0001827)	3.40912703
14	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	3.36634864
15	Methylmalonic acidemia (HP:0002912)	3.24729445
16	Pancreatic cysts (HP:0001737)	3.09637698
17	Cortical dysplasia (HP:0002539)	3.07221233
18	Absent speech (HP:0001344)	3.00404789
19	Spastic diplegia (HP:0001264)	2.93221225
20	Poor coordination (HP:0002370)	2.87665097
21	Broad foot (HP:0001769)	2.83894028
22	Specific learning disability (HP:0001328)	2.74336836
23	Occipital encephalocele (HP:0002085)	2.73494016
24	Pancreatic fibrosis (HP:0100732)	2.73286985
25	Microvesicular hepatic steatosis (HP:0001414)	2.67975379
26	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.61082410
27	Abnormality of serine family amino acid metabolism (HP:0010894)	2.57737938
28	Abnormality of glycine metabolism (HP:0010895)	2.57737938
29	Inability to walk (HP:0002540)	2.56445844
30	Polyphagia (HP:0002591)	2.56099000
31	Abnormality of the anterior horn cell (HP:0006802)	2.53578190
32	Degeneration of anterior horn cells (HP:0002398)	2.53578190
33	True hermaphroditism (HP:0010459)	2.52321922
34	Cerebellar dysplasia (HP:0007033)	2.50816754
35	Delayed CNS myelination (HP:0002188)	2.48524075
36	Carpal bone hypoplasia (HP:0001498)	2.47825817
37	Stenosis of the external auditory canal (HP:0000402)	2.47178933
38	Abnormality of the septum pellucidum (HP:0007375)	2.43054552
39	Methylmalonic aciduria (HP:0012120)	2.40812010
40	Exercise-induced muscle cramps (HP:0003710)	2.38373375
41	Increased serum pyruvate (HP:0003542)	2.36372638
42	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.33631903
43	Pendular nystagmus (HP:0012043)	2.33175614
44	Drooling (HP:0002307)	2.31084881
45	Absent septum pellucidum (HP:0001331)	2.30854737
46	Pachygyria (HP:0001302)	2.23455868
47	Abnormality of the lower motor neuron (HP:0002366)	2.22964877
48	Amyotrophic lateral sclerosis (HP:0007354)	2.21693038
49	Brushfield spots (HP:0001088)	2.19679313
50	Ketosis (HP:0001946)	2.15173164
51	Abnormality of the labia minora (HP:0012880)	2.12669757
52	Decreased testicular size (HP:0008734)	2.12392655
53	Postaxial hand polydactyly (HP:0001162)	2.12104603
54	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.11643279
55	Excessive salivation (HP:0003781)	2.07240167
56	Bifid tongue (HP:0010297)	2.06223864
57	Hypoplasia of the brainstem (HP:0002365)	2.05032169
58	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.05032169
59	Aplasia/Hypoplasia of the lens (HP:0008063)	2.04848943
60	Abnormality of midbrain morphology (HP:0002418)	2.04518623
61	Molar tooth sign on MRI (HP:0002419)	2.04518623
62	Hyperglycinuria (HP:0003108)	2.04230116
63	Sensorimotor neuropathy (HP:0007141)	2.04076377
64	Cerebral edema (HP:0002181)	2.03432419
65	Sclerocornea (HP:0000647)	2.01746899
66	Shoulder girdle muscle weakness (HP:0003547)	2.00119629
67	Abolished electroretinogram (ERG) (HP:0000550)	1.97646114
68	Postnatal microcephaly (HP:0005484)	1.96399078
69	Progressive inability to walk (HP:0002505)	1.95984874
70	Decreased central vision (HP:0007663)	1.95398727
71	Acute encephalopathy (HP:0006846)	1.94387832
72	Acute necrotizing encephalopathy (HP:0006965)	1.93812266
73	Fibular aplasia (HP:0002990)	1.93213090
74	Abnormal mitochondria in muscle tissue (HP:0008316)	1.93048317
75	Rimmed vacuoles (HP:0003805)	1.91575326
76	Hemiparesis (HP:0001269)	1.90555508
77	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.89616577
78	Abnormality of glycolysis (HP:0004366)	1.89394983
79	Renal dysplasia (HP:0000110)	1.88258922
80	Retinal atrophy (HP:0001105)	1.87455545
81	Absent hand (HP:0004050)	1.86735302
82	Abnormality of the motor neurons (HP:0002450)	1.85902353
83	Abnormal neuron morphology (HP:0012757)	1.85902353
84	Increased corneal curvature (HP:0100692)	1.85258270
85	Keratoconus (HP:0000563)	1.85258270
86	Patellar aplasia (HP:0006443)	1.84797464
87	Short tibia (HP:0005736)	1.83134440
88	Postaxial foot polydactyly (HP:0001830)	1.81954519
89	Abnormality of serum amino acid levels (HP:0003112)	1.81773427
90	Palpebral edema (HP:0100540)	1.80105285
91	Maternal diabetes (HP:0009800)	1.79736295
92	Colon cancer (HP:0003003)	1.79504928
93	Aplasia/Hypoplasia of the patella (HP:0006498)	1.79262881
94	Homocystinuria (HP:0002156)	1.74548509
95	Abnormality of homocysteine metabolism (HP:0010919)	1.74548509
96	Abnormality of vitamin B metabolism (HP:0004340)	1.72632540
97	Dental crowding (HP:0000678)	1.72068815
98	Mutism (HP:0002300)	1.71822599
99	Dandy-Walker malformation (HP:0001305)	1.70240510
100	Lethargy (HP:0001254)	1.69797859

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	4.90352510
2	TRIM28	4.61653713
3	MAP2K7	3.97107343
4	SRPK1	3.90081722
5	CASK	3.71705192
6	BCR	3.57744845
7	RPS6KA4	3.02210619
8	MAP3K4	2.91029197
9	CDK19	2.76110826
10	CSNK1G3	2.44583031
11	EPHA4	2.43055970
12	CSNK1G2	2.28436544
13	MAP4K2	2.23929184
14	CSNK1A1L	2.23720573
15	EPHA3	2.07058854
16	TNK2	1.99381533
17	CSNK1G1	1.98462195
18	ERBB3	1.84282859
19	PINK1	1.83745552
20	DYRK2	1.76079792
21	STK38L	1.64748520
22	DYRK3	1.61830559
23	PLK2	1.46174459
24	TSSK6	1.33236825
25	MARK1	1.28210614
26	WNK3	1.13613787
27	TESK2	1.13531654
28	LIMK1	1.11834682
29	GRK1	1.08474637
30	MAPK13	1.02003445
31	DYRK1B	0.98965896
32	TESK1	0.98656443
33	MAP2K4	0.97666907
34	PAK6	0.97006787
35	AURKA	0.95546760
36	UHMK1	0.90176566
37	VRK1	0.89459211
38	VRK2	0.87965670
39	PAK3	0.84719949
40	PRKCE	0.78356405
41	CSNK1A1	0.77684156
42	PLK1	0.76549390
43	CDC7	0.76270905
44	MUSK	0.72808061
45	RPS6KA5	0.72178127
46	ADRBK2	0.71979670
47	PRKCG	0.71847288
48	KDR	0.65890623
49	DAPK2	0.64543401
50	CDK14	0.60438745
51	MINK1	0.59178298
52	EPHB1	0.54148792
53	MAP3K5	0.54005901
54	LMTK2	0.52587553
55	NEK1	0.50408759
56	PAK4	0.49130054
57	ZAK	0.49002871
58	DYRK1A	0.47498005
59	CDK11A	0.47365005
60	FER	0.47286251
61	NTRK2	0.45830026
62	CDK18	0.45156055
63	CAMK2A	0.44444994
64	CAMK1	0.42223776
65	ATR	0.41509475
66	CDK3	0.41280225
67	PRKACB	0.40848998
68	CDK5	0.38773168
69	MKNK1	0.38403284
70	CDK15	0.37466304
71	PLK3	0.37057463
72	CSNK2A1	0.36975836
73	PLK4	0.36749022
74	BUB1	0.35795695
75	STK38	0.34731440
76	AURKB	0.34093949
77	DAPK1	0.33823155
78	CAMK2B	0.33606432
79	MAP3K6	0.33095013
80	GRK6	0.32458792
81	CAMK2G	0.28236228
82	MAPK9	0.28142609
83	MAP3K10	0.27429443
84	PRKAA1	0.27270034
85	CSNK1D	0.27161586
86	FGFR1	0.26620706
87	INSRR	0.26208946
88	NUAK1	0.25441537
89	PRKACA	0.24148076
90	GRK7	0.22768254
91	BRSK1	0.22326537
92	ERBB4	0.21792455
93	ABL1	0.21780304
94	FGR	0.21697545
95	CSNK2A2	0.20445334
96	CDK6	0.20020676
97	EGFR	0.19951085
98	OXSR1	0.19338721
99	IGF1R	0.18708754
100	CSNK1E	0.18298532

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	5.33617002
2	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	3.57730516
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.31365698
4	Steroid biosynthesis_Homo sapiens_hsa00100	2.99373001
5	Butanoate metabolism_Homo sapiens_hsa00650	2.54033352
6	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.36513023
7	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.12472897
8	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.08417037
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.04427969
10	Propanoate metabolism_Homo sapiens_hsa00640	1.97670377
11	Oxidative phosphorylation_Homo sapiens_hsa00190	1.93558527
12	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.87346825
13	Sulfur relay system_Homo sapiens_hsa04122	1.85205749
14	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.68325017
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.67486295
16	Spliceosome_Homo sapiens_hsa03040	1.62938109
17	RNA polymerase_Homo sapiens_hsa03020	1.58011214
18	Parkinsons disease_Homo sapiens_hsa05012	1.55566206
19	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.54863321
20	Base excision repair_Homo sapiens_hsa03410	1.54721837
21	Protein export_Homo sapiens_hsa03060	1.46688633
22	Basal transcription factors_Homo sapiens_hsa03022	1.42496098
23	RNA transport_Homo sapiens_hsa03013	1.40047452
24	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.39498094
25	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.36892984
26	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.36725241
27	Taste transduction_Homo sapiens_hsa04742	1.35208345
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.34838895
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.34758973
30	Nicotine addiction_Homo sapiens_hsa05033	1.32516615
31	Mismatch repair_Homo sapiens_hsa03430	1.31614558
32	RNA degradation_Homo sapiens_hsa03018	1.23164217
33	Huntingtons disease_Homo sapiens_hsa05016	1.17605164
34	Proteasome_Homo sapiens_hsa03050	1.13434788
35	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.13089305
36	DNA replication_Homo sapiens_hsa03030	1.12680421
37	Phototransduction_Homo sapiens_hsa04744	1.12013262
38	Vibrio cholerae infection_Homo sapiens_hsa05110	1.11919548
39	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.09127070
40	Homologous recombination_Homo sapiens_hsa03440	1.08844042
41	Carbon metabolism_Homo sapiens_hsa01200	1.07780116
42	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.05470782
43	GABAergic synapse_Homo sapiens_hsa04727	1.04798152
44	Folate biosynthesis_Homo sapiens_hsa00790	1.04796464
45	Arginine and proline metabolism_Homo sapiens_hsa00330	1.04471496
46	Peroxisome_Homo sapiens_hsa04146	1.01782642
47	beta-Alanine metabolism_Homo sapiens_hsa00410	0.95132988
48	mRNA surveillance pathway_Homo sapiens_hsa03015	0.93273602
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.92961814
50	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.90797321
51	Alzheimers disease_Homo sapiens_hsa05010	0.90331832
52	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.82531027
53	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.79273909
54	Purine metabolism_Homo sapiens_hsa00230	0.77693880
55	Pyrimidine metabolism_Homo sapiens_hsa00240	0.75498768
56	Fatty acid elongation_Homo sapiens_hsa00062	0.75204094
57	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.75081945
58	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.74927136
59	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.74241467
60	Shigellosis_Homo sapiens_hsa05131	0.73313275
61	Fanconi anemia pathway_Homo sapiens_hsa03460	0.72375747
62	Metabolic pathways_Homo sapiens_hsa01100	0.72230692
63	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.67709079
64	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.67341166
65	Cardiac muscle contraction_Homo sapiens_hsa04260	0.64102883
66	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.63634815
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.63171681
68	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.60790284
69	Alcoholism_Homo sapiens_hsa05034	0.60224574
70	Oocyte meiosis_Homo sapiens_hsa04114	0.60078546
71	Hippo signaling pathway_Homo sapiens_hsa04390	0.58868063
72	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.58799768
73	Morphine addiction_Homo sapiens_hsa05032	0.58308855
74	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.55677339
75	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.55501933
76	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.50824841
77	Axon guidance_Homo sapiens_hsa04360	0.49346507
78	Retinol metabolism_Homo sapiens_hsa00830	0.48778066
79	Non-homologous end-joining_Homo sapiens_hsa03450	0.47944385
80	Tight junction_Homo sapiens_hsa04530	0.47295994
81	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.46879034
82	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.44548760
83	Circadian rhythm_Homo sapiens_hsa04710	0.42980667
84	Nucleotide excision repair_Homo sapiens_hsa03420	0.40748278
85	One carbon pool by folate_Homo sapiens_hsa00670	0.40406333
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.39782319
87	Regulation of autophagy_Homo sapiens_hsa04140	0.38724589
88	Cell cycle_Homo sapiens_hsa04110	0.38447225
89	Tryptophan metabolism_Homo sapiens_hsa00380	0.36462443
90	Glutathione metabolism_Homo sapiens_hsa00480	0.36285019
91	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.36204202
92	Glutamatergic synapse_Homo sapiens_hsa04724	0.35801457
93	Caffeine metabolism_Homo sapiens_hsa00232	0.34241514
94	Dopaminergic synapse_Homo sapiens_hsa04728	0.33312386
95	Cocaine addiction_Homo sapiens_hsa05030	0.29673926
96	ABC transporters_Homo sapiens_hsa02010	0.28793554
97	Chemical carcinogenesis_Homo sapiens_hsa05204	0.28137291
98	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.26310816
99	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.26153680
100	Pentose phosphate pathway_Homo sapiens_hsa00030	0.26036665

WDR45BP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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