WDR46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.77032131
2DNA deamination (GO:0045006)4.65970960
3formation of translation preinitiation complex (GO:0001731)4.63715981
4nucleobase biosynthetic process (GO:0046112)4.62877446
5DNA strand elongation involved in DNA replication (GO:0006271)4.58072242
6maturation of SSU-rRNA (GO:0030490)4.54930016
7folic acid-containing compound biosynthetic process (GO:0009396)4.53622115
8DNA replication initiation (GO:0006270)4.38138626
9DNA strand elongation (GO:0022616)4.35990121
10purine nucleobase biosynthetic process (GO:0009113)4.27977254
11protein maturation by protein folding (GO:0022417)4.27749158
12ribosomal small subunit assembly (GO:0000028)4.24137234
13ribosome assembly (GO:0042255)4.22547484
14ribosome biogenesis (GO:0042254)4.18397318
15protein localization to kinetochore (GO:0034501)4.11912296
16telomere maintenance via semi-conservative replication (GO:0032201)4.07625373
17Golgi transport vesicle coating (GO:0048200)4.05683190
18COPI coating of Golgi vesicle (GO:0048205)4.05683190
19IMP biosynthetic process (GO:0006188)4.03446547
20proline biosynthetic process (GO:0006561)4.01281437
21viral transcription (GO:0019083)3.99674204
22translational termination (GO:0006415)3.94810865
23ribonucleoprotein complex biogenesis (GO:0022613)3.94401512
24mitotic nuclear envelope disassembly (GO:0007077)3.92054797
25ribosomal large subunit biogenesis (GO:0042273)3.83713299
26peptidyl-arginine omega-N-methylation (GO:0035247)3.77757914
27DNA replication checkpoint (GO:0000076)3.75228884
28translational initiation (GO:0006413)3.73465839
29translational elongation (GO:0006414)3.71391807
30folic acid metabolic process (GO:0046655)3.70259263
31ribosomal small subunit biogenesis (GO:0042274)3.68128328
32mitotic metaphase plate congression (GO:0007080)3.61623586
33nuclear envelope disassembly (GO:0051081)3.59766190
34membrane disassembly (GO:0030397)3.59766190
35IMP metabolic process (GO:0046040)3.57066063
36rRNA processing (GO:0006364)3.54027682
37telomere maintenance via recombination (GO:0000722)3.53672131
38regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.52576086
39DNA replication-dependent nucleosome organization (GO:0034723)3.51554844
40DNA replication-dependent nucleosome assembly (GO:0006335)3.51554844
41nuclear pore organization (GO:0006999)3.51406705
42protein localization to chromosome, centromeric region (GO:0071459)3.47502413
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.46331074
44rRNA metabolic process (GO:0016072)3.43217935
45viral mRNA export from host cell nucleus (GO:0046784)3.41318073
46spliceosomal snRNP assembly (GO:0000387)3.40708222
47establishment of viral latency (GO:0019043)3.35237012
48telomere maintenance via telomere lengthening (GO:0010833)3.34915646
49mitotic recombination (GO:0006312)3.34648472
50pseudouridine synthesis (GO:0001522)3.33610591
51spliceosomal tri-snRNP complex assembly (GO:0000244)3.33130206
52histone arginine methylation (GO:0034969)3.30044618
53pentose-phosphate shunt (GO:0006098)3.28164646
54DNA duplex unwinding (GO:0032508)3.26773610
55SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.26576999
56DNA geometric change (GO:0032392)3.24190978
57NIK/NF-kappaB signaling (GO:0038061)3.23915554
58deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.20746107
59nuclear pore complex assembly (GO:0051292)3.17590198
60protein targeting to ER (GO:0045047)3.17327504
61cotranslational protein targeting to membrane (GO:0006613)3.14706859
62pinocytosis (GO:0006907)3.11980190
63rRNA transcription (GO:0009303)3.10494078
64negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.10137059
65cellular protein complex disassembly (GO:0043624)3.08096954
66viral life cycle (GO:0019058)3.06358768
67regulation of spindle organization (GO:0090224)3.05830394
68pteridine-containing compound biosynthetic process (GO:0042559)3.05201565
69regulation of translational fidelity (GO:0006450)3.05134461
70GDP-mannose metabolic process (GO:0019673)3.04671987
71metaphase plate congression (GO:0051310)3.04580044
72mitotic nuclear envelope reassembly (GO:0007084)3.03299902
73nuclear envelope reassembly (GO:0031468)3.03299902
74nucleobase-containing small molecule interconversion (GO:0015949)3.03219188
75nucleotide-excision repair, DNA gap filling (GO:0006297)3.02337906
76regulation of mammary gland epithelial cell proliferation (GO:0033599)3.02277744
77negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.00203197
78establishment of protein localization to endoplasmic reticulum (GO:0072599)2.99591320
79chromatin remodeling at centromere (GO:0031055)2.99543330
80heterochromatin organization (GO:0070828)2.98562493
81regulation of mitochondrial translation (GO:0070129)2.97490144
82protein localization to endoplasmic reticulum (GO:0070972)2.97002500
83CENP-A containing nucleosome assembly (GO:0034080)2.96315696
84DNA replication-independent nucleosome organization (GO:0034724)2.93583020
85DNA replication-independent nucleosome assembly (GO:0006336)2.93583020
86protein complex disassembly (GO:0043241)2.89995523
87NADPH regeneration (GO:0006740)2.88051358
88peptidyl-arginine N-methylation (GO:0035246)2.87061516
89peptidyl-arginine methylation (GO:0018216)2.87061516
90mitotic sister chromatid segregation (GO:0000070)2.86490344
91nuclear envelope organization (GO:0006998)2.86415131
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.85938318
93RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.84705933
94mRNA splicing, via spliceosome (GO:0000398)2.84705933
95RNA splicing, via transesterification reactions (GO:0000375)2.84627441
96rRNA modification (GO:0000154)2.84227246
97tetrahydrofolate metabolic process (GO:0046653)2.83931313
98proteasome assembly (GO:0043248)2.83782135
99negative regulation of RNA splicing (GO:0033119)2.83183548
100nuclear-transcribed mRNA catabolic process (GO:0000956)2.82844084
101establishment of integrated proviral latency (GO:0075713)2.81664382
102translation (GO:0006412)2.81500075
103maturation of 5.8S rRNA (GO:0000460)2.80698182
104L-serine metabolic process (GO:0006563)2.79334870
105regulation of nuclear cell cycle DNA replication (GO:0033262)2.79035737
106regulation of translational termination (GO:0006449)2.77495037
107cellular component biogenesis (GO:0044085)2.77291207
108transcription from mitochondrial promoter (GO:0006390)2.76286364
109somatic diversification of immune receptors via somatic mutation (GO:0002566)2.75468000
110somatic hypermutation of immunoglobulin genes (GO:0016446)2.75468000
111glycine metabolic process (GO:0006544)2.74455985
112macromolecular complex disassembly (GO:0032984)2.73369918
113RNA catabolic process (GO:0006401)2.73365201
114negative regulation of ligase activity (GO:0051352)2.73084196
115negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.73084196
116tRNA aminoacylation for protein translation (GO:0006418)2.72924406
117folic acid-containing compound metabolic process (GO:0006760)2.72512473
118transcription-coupled nucleotide-excision repair (GO:0006283)2.72402123
119spliceosomal complex assembly (GO:0000245)2.71660377
120kinetochore organization (GO:0051383)2.71147707
121pore complex assembly (GO:0046931)2.70861749
122anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.69753977
123tRNA methylation (GO:0030488)2.69646596
124ncRNA processing (GO:0034470)2.69132543
125mRNA catabolic process (GO:0006402)2.69082177
126protein complex localization (GO:0031503)2.68378840
127mitotic chromosome condensation (GO:0007076)2.68018577
128glucose catabolic process (GO:0006007)2.67453848
129regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.67190527
130maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.66919198
131regulation of translation in response to stress (GO:0043555)2.66740713
132mitochondrial fusion (GO:0008053)2.63398422
133protein retention in ER lumen (GO:0006621)2.59768385
134regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.59473075
135retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.55143287
136positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.54618193
137UV protection (GO:0009650)2.53557326
138negative regulation of B cell apoptotic process (GO:0002903)2.53215043
139negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.53052725
140negative regulation of mRNA processing (GO:0050686)2.49404310
141tRNA aminoacylation (GO:0043039)2.44792063
142amino acid activation (GO:0043038)2.44792063
143rRNA methylation (GO:0031167)2.44560495
144antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.44008582
145proline metabolic process (GO:0006560)2.41630266
146negative regulation of DNA-templated transcription, elongation (GO:0032785)2.41289523
147DNA conformation change (GO:0071103)2.38959257
148DNA topological change (GO:0006265)2.37656455
149protein export from nucleus (GO:0006611)2.36442743
150mitochondrial RNA metabolic process (GO:0000959)2.35790720
151positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.35605054
152pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.35082600
153pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.34490703
154pentose metabolic process (GO:0019321)2.34454492

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.49416435
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.29596959
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.92378561
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.38400033
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.03394580
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00162333
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.79949157
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74465608
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.73104228
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.64651343
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.58048026
12* EST1_17652178_ChIP-ChIP_JURKAT_Human2.56481489
13* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.43008487
14* GABP_17652178_ChIP-ChIP_JURKAT_Human2.38325509
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33392155
16* XRN2_22483619_ChIP-Seq_HELA_Human2.28893933
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18364994
18MYC_22102868_ChIP-Seq_BL_Human2.16754894
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.10746399
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.05294032
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01465829
22VDR_23849224_ChIP-Seq_CD4+_Human1.98761042
23AR_21909140_ChIP-Seq_LNCAP_Human1.93109677
24E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89085526
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85408333
26FOXP3_21729870_ChIP-Seq_TREG_Human1.83923839
27DCP1A_22483619_ChIP-Seq_HELA_Human1.83771135
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83293610
29GABP_19822575_ChIP-Seq_HepG2_Human1.82081156
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.79993736
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78006946
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72483064
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69751640
34CIITA_25753668_ChIP-Seq_RAJI_Human1.69256421
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68221964
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68135044
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67736327
38TTF2_22483619_ChIP-Seq_HELA_Human1.64752070
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64197893
40* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62990549
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.58076411
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56647337
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56394198
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50586279
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50085121
46KDM5A_27292631_Chip-Seq_BREAST_Human1.49032094
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.48592871
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48064230
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45815229
50* YY1_21170310_ChIP-Seq_MESCs_Mouse1.43192569
51VDR_21846776_ChIP-Seq_THP-1_Human1.42402389
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38849780
53* LXR_22292898_ChIP-Seq_THP-1_Human1.36864873
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36292722
55SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.34961449
56KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33590014
57* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33562270
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33168290
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30470190
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30074859
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28681855
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.28004717
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27539542
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27157411
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.26623201
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24245301
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23356387
68* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23185913
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21168711
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21026094
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20325546
72RACK7_27058665_Chip-Seq_MCF-7_Human1.19452919
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18824791
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18809057
75ELK1_19687146_ChIP-ChIP_HELA_Human1.18800524
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17893225
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.16914377
78TFEB_21752829_ChIP-Seq_HELA_Human1.15986131
79MAF_26560356_Chip-Seq_TH1_Human1.15744870
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13385469
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11146181
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10711566
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09258281
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08408401
85TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08331520
86STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08216577
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07589003
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07382797
89MAF_26560356_Chip-Seq_TH2_Human1.07374598
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06928966
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05701952
92TP63_19390658_ChIP-ChIP_HaCaT_Human1.04122454
93TP63_17297297_ChIP-ChIP_HaCaT_Human1.02826907
94NCOR1_26117541_ChIP-Seq_K562_Human1.02394615
95ATF3_27146783_Chip-Seq_COLON_Human1.01929912
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01516097
97ELF1_20517297_ChIP-Seq_JURKAT_Human1.01174933
98UTX_26944678_Chip-Seq_JUKART_Human1.00969436
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00452048
100P68_20966046_ChIP-Seq_HELA_Human1.00183663
101SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99060827
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98902255
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95255700
104CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93885592
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92797416
106SPI1_23547873_ChIP-Seq_NB4_Human0.92160846
107SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91578800
108NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90398606
109CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90314579
110* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90084443
111TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90022507
112ZNF263_19887448_ChIP-Seq_K562_Human0.88479068
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87309035
114TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85996176
115MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.85662422
116OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84024673
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.82820978
118KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.82517622
119KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82517622
120KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.82517622
121MYC_18940864_ChIP-ChIP_HL60_Human0.81543791
122SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81053515
123TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80276011
124NANOG_21062744_ChIP-ChIP_HESCs_Human0.79890495
125ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79800408

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.09385842
2MP0003111_abnormal_nucleus_morphology4.17651029
3MP0004957_abnormal_blastocyst_morpholog4.13896262
4MP0010094_abnormal_chromosome_stability3.95869186
5MP0003077_abnormal_cell_cycle3.62333254
6MP0008057_abnormal_DNA_replication3.31185516
7MP0002877_abnormal_melanocyte_morpholog2.96971571
8MP0010352_gastrointestinal_tract_polyps2.74940454
9MP0008058_abnormal_DNA_repair2.69817983
10MP0002396_abnormal_hematopoietic_system2.61469250
11MP0005451_abnormal_body_composition2.56187303
12MP0008007_abnormal_cellular_replicative2.48477642
13MP0001730_embryonic_growth_arrest2.44279535
14MP0008932_abnormal_embryonic_tissue2.24204745
15MP0000350_abnormal_cell_proliferation2.17469561
16MP0005058_abnormal_lysosome_morphology2.15605127
17MP0003806_abnormal_nucleotide_metabolis2.14202657
18MP0008260_abnormal_autophagy2.01907421
19MP0008438_abnormal_cutaneous_collagen1.99578871
20MP0000490_abnormal_crypts_of1.83989108
21MP0003123_paternal_imprinting1.82439805
22MP0001348_abnormal_lacrimal_gland1.81763697
23MP0010307_abnormal_tumor_latency1.79539073
24MP0005380_embryogenesis_phenotype1.76388727
25MP0001672_abnormal_embryogenesis/_devel1.76388727
26MP0003786_premature_aging1.68417382
27MP0001697_abnormal_embryo_size1.67594594
28MP0003984_embryonic_growth_retardation1.63229102
29MP0002080_prenatal_lethality1.63186071
30MP0005397_hematopoietic_system_phenotyp1.60037602
31MP0001545_abnormal_hematopoietic_system1.60037602
32MP0004185_abnormal_adipocyte_glucose1.59888896
33MP0002088_abnormal_embryonic_growth/wei1.59106027
34MP0009333_abnormal_splenocyte_physiolog1.54794509
35MP0005257_abnormal_intraocular_pressure1.51214251
36MP0004808_abnormal_hematopoietic_stem1.50576890
37MP0001661_extended_life_span1.49499264
38MP0002085_abnormal_embryonic_tissue1.48998673
39MP0002019_abnormal_tumor_incidence1.46849003
40MP0000313_abnormal_cell_death1.46548876
41MP0003763_abnormal_thymus_physiology1.44589475
42MP0003705_abnormal_hypodermis_morpholog1.43624933
43MP0002086_abnormal_extraembryonic_tissu1.43230378
44MP0001835_abnormal_antigen_presentation1.43128273
45MP0010030_abnormal_orbit_morphology1.42996711
46MP0004197_abnormal_fetal_growth/weight/1.42758914
47MP0004233_abnormal_muscle_weight1.41603370
48MP0002084_abnormal_developmental_patter1.41534795
49MP0003718_maternal_effect1.32652773
50MP0005076_abnormal_cell_differentiation1.32031757
51MP0008877_abnormal_DNA_methylation1.30789996
52MP0002796_impaired_skin_barrier1.28081837
53MP0002060_abnormal_skin_morphology1.26033972
54MP0000703_abnormal_thymus_morphology1.21883898
55MP0002722_abnormal_immune_system1.17727085
56MP0005464_abnormal_platelet_physiology1.16689623
57MP0002398_abnormal_bone_marrow1.15662850
58MP0001293_anophthalmia1.15389943
59MP0003567_abnormal_fetal_cardiomyocyte1.15087257
60MP0009840_abnormal_foam_cell1.14028575
61MP0009278_abnormal_bone_marrow1.12197835
62MP0000689_abnormal_spleen_morphology1.10104483
63MP0000858_altered_metastatic_potential1.09165446
64MP0001243_abnormal_dermal_layer1.07767778
65MP0001881_abnormal_mammary_gland1.06874229
66MP0000678_abnormal_parathyroid_gland1.05803062
67MP0005023_abnormal_wound_healing1.05654639
68MP0009053_abnormal_anal_canal1.04488605
69MP0003453_abnormal_keratinocyte_physiol1.04359099
70MP0004947_skin_inflammation1.04325814
71MP0006036_abnormal_mitochondrial_physio1.04309836
72MP0009672_abnormal_birth_weight1.03379819
73MP0003566_abnormal_cell_adhesion1.02293370
74MP0003191_abnormal_cellular_cholesterol1.00827080
75MP0003186_abnormal_redox_activity1.00755893
76MP0006035_abnormal_mitochondrial_morpho1.00406361
77MP0005000_abnormal_immune_tolerance1.00358882
78MP0004272_abnormal_basement_membrane0.98544100
79MP0003890_abnormal_embryonic-extraembry0.97789078
80MP0000003_abnormal_adipose_tissue0.95428281
81MP0000358_abnormal_cell_content/0.94852173
82MP0002429_abnormal_blood_cell0.91932072
83MP0000537_abnormal_urethra_morphology0.91168291
84MP0003119_abnormal_digestive_system0.91162334
85MP0001819_abnormal_immune_cell0.89431757
86MP0002210_abnormal_sex_determination0.89194084
87MP0010234_abnormal_vibrissa_follicle0.89082894
88MP0005330_cardiomyopathy0.87796642
89MP0004858_abnormal_nervous_system0.87007649
90MP0001145_abnormal_male_reproductive0.86990916
91MP0004133_heterotaxia0.86963659
92MP0002452_abnormal_antigen_presenting0.86759074
93MP0002132_abnormal_respiratory_system0.86429574
94MP0002166_altered_tumor_susceptibility0.86126460
95MP0001853_heart_inflammation0.84494452
96MP0009697_abnormal_copulation0.83821246
97MP0001216_abnormal_epidermal_layer0.83172397
98MP0002006_tumorigenesis0.82355509
99MP0000477_abnormal_intestine_morphology0.82008390
100MP0001790_abnormal_immune_system0.80935401
101MP0005387_immune_system_phenotype0.80935401
102MP0002111_abnormal_tail_morphology0.80885585
103MP0001915_intracranial_hemorrhage0.80157530
104MP0002723_abnormal_immune_serum0.79682397
105MP0005621_abnormal_cell_physiology0.79106543
106MP0006054_spinal_hemorrhage0.78905688
107MP0003448_altered_tumor_morphology0.78846166
108MP0000716_abnormal_immune_system0.78447792
109MP0005384_cellular_phenotype0.78032564
110MP0002653_abnormal_ependyma_morphology0.77729525
111MP0002160_abnormal_reproductive_system0.77422650
112MP0000685_abnormal_immune_system0.76534544
113MP0003315_abnormal_perineum_morphology0.74843421
114MP0005025_abnormal_response_to0.74708060
115MP0009931_abnormal_skin_appearance0.74533990
116MP0001849_ear_inflammation0.73967833
117MP0003172_abnormal_lysosome_physiology0.71695977
118MP0000598_abnormal_liver_morphology0.71192198
119MP0003221_abnormal_cardiomyocyte_apopto0.70763616
120MP0002092_abnormal_eye_morphology0.69776022
121MP0002405_respiratory_system_inflammati0.69074117
122MP0000653_abnormal_sex_gland0.67950147
123MP0000750_abnormal_muscle_regeneration0.67400241
124MP0001800_abnormal_humoral_immune0.66783712
125MP0005075_abnormal_melanosome_morpholog0.66731122
126MP0009703_decreased_birth_body0.65646161
127MP0004264_abnormal_extraembryonic_tissu0.65143649
128MP0001929_abnormal_gametogenesis0.65067676
129MP0003436_decreased_susceptibility_to0.63164798
130MP0003656_abnormal_erythrocyte_physiolo0.62258530
131MP0005501_abnormal_skin_physiology0.60500675
132MP0005389_reproductive_system_phenotype0.59351157
133MP0000428_abnormal_craniofacial_morphol0.58586267
134MP0001119_abnormal_female_reproductive0.58371428
135MP0010155_abnormal_intestine_physiology0.57524524
136MP0001873_stomach_inflammation0.57268758
137MP0000371_diluted_coat_color0.55587230
138MP0000465_gastrointestinal_hemorrhage0.55526303
139MP0008770_decreased_survivor_rate0.53875767
140MP0002420_abnormal_adaptive_immunity0.53844678
141MP0003941_abnormal_skin_development0.53254744

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.58554751
2Abnormality of cells of the erythroid lineage (HP:0012130)4.29596165
3Birth length less than 3rd percentile (HP:0003561)4.13655427
4Abnormal number of erythroid precursors (HP:0012131)4.09919843
5Selective tooth agenesis (HP:0001592)3.92508428
6Breast hypoplasia (HP:0003187)3.69112607
7Oral leukoplakia (HP:0002745)3.63270279
8Premature rupture of membranes (HP:0001788)3.41213934
9Degeneration of anterior horn cells (HP:0002398)3.32302263
10Abnormality of the anterior horn cell (HP:0006802)3.32302263
11Colon cancer (HP:0003003)3.23905649
12Microvesicular hepatic steatosis (HP:0001414)3.18487056
13Ragged-red muscle fibers (HP:0003200)3.17476252
14Vertebral compression fractures (HP:0002953)3.17329469
15Trismus (HP:0000211)3.04554912
16Ependymoma (HP:0002888)3.03691878
17Macrocytic anemia (HP:0001972)3.01688880
18Pallor (HP:0000980)3.00909170
19Aplastic anemia (HP:0001915)3.00109833
20Rough bone trabeculation (HP:0100670)2.99986408
21Carpal bone hypoplasia (HP:0001498)2.98454360
22Multiple enchondromatosis (HP:0005701)2.92123959
23Patellar aplasia (HP:0006443)2.83112088
24Microretrognathia (HP:0000308)2.79478198
25Medulloblastoma (HP:0002885)2.78547428
26Absent thumb (HP:0009777)2.77243440
27Chromsome breakage (HP:0040012)2.73264808
28Hyperacusis (HP:0010780)2.72865925
29Abnormality of pyrimidine metabolism (HP:0004353)2.70873513
30Aplasia/Hypoplasia of the patella (HP:0006498)2.68762976
31Achilles tendon contracture (HP:0001771)2.68165873
32Basal cell carcinoma (HP:0002671)2.64879221
33Thrombocytosis (HP:0001894)2.64620608
34Nonimmune hydrops fetalis (HP:0001790)2.64151530
35Hypertensive crisis (HP:0100735)2.59676599
36Impulsivity (HP:0100710)2.58117392
37Cholecystitis (HP:0001082)2.57900596
38Abnormal gallbladder physiology (HP:0012438)2.57900596
39Chromosomal breakage induced by crosslinking agents (HP:0003221)2.56422847
40Rhabdomyosarcoma (HP:0002859)2.50541423
41Cerebral hypomyelination (HP:0006808)2.49859601
42Neoplasm of the pancreas (HP:0002894)2.48058962
43Abnormal number of incisors (HP:0011064)2.43594422
44Gastrointestinal inflammation (HP:0004386)2.43490728
45Abnormality of the preputium (HP:0100587)2.41439757
46Premature graying of hair (HP:0002216)2.41294357
47Progressive muscle weakness (HP:0003323)2.41128510
48Abnormality of the Achilles tendon (HP:0005109)2.37622179
49Squamous cell carcinoma (HP:0002860)2.37589423
5011 pairs of ribs (HP:0000878)2.32738171
51Abnormality of the umbilical cord (HP:0010881)2.32552638
52Abnormality of chromosome stability (HP:0003220)2.29547547
53Type I transferrin isoform profile (HP:0003642)2.29379673
54Absent radius (HP:0003974)2.27937467
55Premature ovarian failure (HP:0008209)2.25453606
56Meckel diverticulum (HP:0002245)2.25184000
57Myelodysplasia (HP:0002863)2.24386224
58Abnormality of reticulocytes (HP:0004312)2.23663280
59Protrusio acetabuli (HP:0003179)2.22648522
60Agnosia (HP:0010524)2.21577204
61Fatigue (HP:0012378)2.20910083
62Insomnia (HP:0100785)2.19360381
63Centrally nucleated skeletal muscle fibers (HP:0003687)2.18960984
64Hepatosplenomegaly (HP:0001433)2.16684418
65Cellular immunodeficiency (HP:0005374)2.15769664
66Progressive external ophthalmoplegia (HP:0000590)2.14957892
67Abnormality of the distal phalanges of the toes (HP:0010182)2.14434941
68Abnormality of the ileum (HP:0001549)2.13923673
69Proximal placement of thumb (HP:0009623)2.13898379
70Biconcave vertebral bodies (HP:0004586)2.11782510
71Inflammation of the large intestine (HP:0002037)2.11661174
72Cellulitis (HP:0100658)2.11387492
73Hypergonadotropic hypogonadism (HP:0000815)2.10952545
74Atrophy/Degeneration involving motor neurons (HP:0007373)2.09922024
75Generalized amyotrophy (HP:0003700)2.08902685
76Aplasia involving forearm bones (HP:0009822)2.06665939
77Absent forearm bone (HP:0003953)2.06665939
78Bone marrow hypocellularity (HP:0005528)2.05933332
79Abnormal trabecular bone morphology (HP:0100671)2.05865959
80Horseshoe kidney (HP:0000085)2.04667460
81Agammaglobulinemia (HP:0004432)2.04371233
82Aplasia/Hypoplasia of the uvula (HP:0010293)2.04243703
83Deviation of the thumb (HP:0009603)2.03621448
84IgM deficiency (HP:0002850)2.02738463
85Poikiloderma (HP:0001029)2.02615443
86Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.01977930
87Elbow flexion contracture (HP:0002987)2.01452717
88Increased connective tissue (HP:0009025)2.00549931
89Distal lower limb amyotrophy (HP:0008944)2.00331663
90Megaloblastic anemia (HP:0001889)1.99992766
91Tracheoesophageal fistula (HP:0002575)1.99842684
92Upper limb muscle weakness (HP:0003484)1.98555953
93Pancytopenia (HP:0001876)1.98469243
94Atresia of the external auditory canal (HP:0000413)1.98300079
95Neoplasm of striated muscle (HP:0009728)1.97498517
96Secondary amenorrhea (HP:0000869)1.96755037
97Prominent nose (HP:0000448)1.95459856
98Missing ribs (HP:0000921)1.91206266
99Short nail (HP:0001799)1.90203204
100Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90180269
101Abnormality of glycolysis (HP:0004366)1.88998792
102Increased intramyocellular lipid droplets (HP:0012240)1.88602799
103Recurrent viral infections (HP:0004429)1.88223038
104Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87426967
105Abnormal protein N-linked glycosylation (HP:0012347)1.87426967
106Abnormal protein glycosylation (HP:0012346)1.87426967
107Abnormal glycosylation (HP:0012345)1.87426967
108Reduced subcutaneous adipose tissue (HP:0003758)1.86965548
109Lymphoma (HP:0002665)1.86146147
110Osteolytic defects of the phalanges of the hand (HP:0009771)1.85611616
111Osteolytic defects of the hand bones (HP:0009699)1.85611616
112Testicular atrophy (HP:0000029)1.84494528
113Distal lower limb muscle weakness (HP:0009053)1.83464867
114Breech presentation (HP:0001623)1.83427632
115Amaurosis fugax (HP:0100576)1.83085785
116Ulnar bowing (HP:0003031)1.82989632
117Rectal prolapse (HP:0002035)1.82265172
118Petechiae (HP:0000967)1.82199309
119Aplasia/hypoplasia of the humerus (HP:0006507)1.81838756
120Orthostatic hypotension (HP:0001278)1.81349895
121Colitis (HP:0002583)1.80875253
122Spastic diplegia (HP:0001264)1.80326622
123Broad face (HP:0000283)1.78896129
124Reduced antithrombin III activity (HP:0001976)1.78160622
125Broad distal phalanx of finger (HP:0009836)1.78152688
126Increased serum ferritin (HP:0003281)1.77456177
127Neoplasm of the oral cavity (HP:0100649)1.77449608
128Glossoptosis (HP:0000162)1.77374379
129Preauricular skin tag (HP:0000384)1.77144675
130Rhabdomyolysis (HP:0003201)1.77120041
131Sloping forehead (HP:0000340)1.76737030
132Glioma (HP:0009733)1.76092669
133Seborrheic dermatitis (HP:0001051)1.75967492
134Slender long bone (HP:0003100)1.75819255
135Duodenal stenosis (HP:0100867)1.75380868
136Small intestinal stenosis (HP:0012848)1.75380868
137Long palpebral fissure (HP:0000637)1.74931325
138Hypokinesia (HP:0002375)1.74758762
139Cleft eyelid (HP:0000625)1.74719984
140Ectopic kidney (HP:0000086)1.74375008
141Entropion (HP:0000621)1.74328301
142Sparse eyelashes (HP:0000653)1.73750220
143Increased muscle lipid content (HP:0009058)1.73526294
144Abnormality of DNA repair (HP:0003254)1.73323391
145Aplasia/Hypoplasia of the thymus (HP:0010515)1.73232970
146Ureteral duplication (HP:0000073)1.72820737
147Abnormal umbilical cord blood vessels (HP:0011403)1.71728783
148Single umbilical artery (HP:0001195)1.71728783
149Abnormality of the fetal cardiovascular system (HP:0010948)1.71728783
150High pitched voice (HP:0001620)1.71447974
151Overlapping toe (HP:0001845)1.71428798
152Abnormality of the calcaneus (HP:0008364)1.71253959
153Abnormality of the astrocytes (HP:0100707)1.71230826
154Astrocytoma (HP:0009592)1.71230826
155Skin tags (HP:0010609)1.70096369
156Abnormality of the tricuspid valve (HP:0001702)1.70023590
157Abnormalities of placenta or umbilical cord (HP:0001194)1.69457086
158Impaired platelet aggregation (HP:0003540)1.68171748
159Abnormal platelet function (HP:0011869)1.68171748
160Back pain (HP:0003418)1.67098974
161Increased serum pyruvate (HP:0003542)1.66786371
162Patellar dislocation (HP:0002999)1.66099486
163Opisthotonus (HP:0002179)1.66084495
164Hypoplasia of the capital femoral epiphysis (HP:0003090)1.65739485
165Hypoplasia of the radius (HP:0002984)1.65720705
166Reticulocytosis (HP:0001923)1.65138932
167Overriding aorta (HP:0002623)1.65028669
168Cafe-au-lait spot (HP:0000957)1.64962619
169Personality changes (HP:0000751)1.64467442
170Short thumb (HP:0009778)1.63901600
171Abnormality of the heme biosynthetic pathway (HP:0010472)1.63440285
172Asplenia (HP:0001746)1.62856904
173Myocardial infarction (HP:0001658)1.60453926
174Fragile skin (HP:0001030)1.60195078
175Premature skin wrinkling (HP:0100678)1.58891996
176Spastic paraparesis (HP:0002313)1.58282560

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.15331387
2WEE13.51661817
3VRK23.50765085
4SMG13.50505857
5CDC73.44338674
6EIF2AK13.10194737
7NEK22.69941679
8IRAK32.44196773
9NME22.40372878
10EEF2K2.29636443
11TESK22.28268939
12CDK122.11089701
13TSSK62.10437498
14TTK2.03165533
15RPS6KA41.91805017
16EIF2AK31.85351217
17CDK71.83705415
18DYRK31.79726996
19RPS6KB21.79651109
20EPHA21.74981343
21MAP3K101.74115730
22NEK11.73832211
23PLK11.69679472
24SRPK11.66443889
25STK101.64255797
26MAP4K11.63350331
27ACVR1B1.60487570
28ATR1.57814100
29STK161.55667332
30SCYL21.55604147
31PRPF4B1.54531673
32MAP3K81.50309227
33PLK41.49084116
34CDK41.48074274
35BRSK21.47669203
36AURKB1.46951628
37PBK1.44177293
38PASK1.43471098
39ARAF1.40258744
40PIM21.39843937
41PKN21.37123857
42PAK41.28720884
43BCKDK1.26099762
44VRK11.25384877
45MKNK11.23421340
46KDR1.18299316
47MAP3K111.18273944
48TLK11.16088931
49CHEK21.15508635
50CHEK11.11848460
51AURKA1.08452289
52FLT31.05916096
53TRIB31.04791053
54PIM11.04247480
55LIMK11.02087858
56TGFBR11.00193696
57MST1R0.97352794
58DAPK10.97265852
59RAF10.97032993
60PLK30.96712141
61LRRK20.96205211
62ERN10.95110800
63MAP3K140.92784296
64MAP2K30.90787056
65STK40.89762542
66ZAP700.89335805
67TTN0.89111847
68ALK0.88714003
69MAPKAPK30.88610893
70BRSK10.87631629
71TESK10.86029747
72TBK10.81482381
73CLK10.81269170
74MKNK20.81220680
75CDK20.80108642
76ATM0.75331794
77NME10.74810083
78GRK60.74467471
79MTOR0.73367187
80PAK10.73265412
81TAF10.73032696
82BRD40.72350977
83CSNK2A20.70173193
84CDK60.69830067
85BTK0.68370662
86ZAK0.67695040
87BRAF0.65132583
88ABL20.58180823
89CSNK2A10.57220572
90TAOK20.56732247
91FGFR40.55468653
92KSR20.54961882
93AKT20.54795492
94JAK30.54713188
95MAP2K20.51543351
96BLK0.50805067
97PAK20.50417374
98LATS20.49881474
99PRKCI0.47787848
100BMX0.47632573
101CDK10.47454299
102ERBB40.47438374
103CDK90.46923379
104STK30.45225379
105RPS6KA50.44899203
106PTK20.44230414
107PTK60.44174401
108SIK30.42829625
109MARK30.42737421
110TAOK10.42694021
111LMTK20.41494010
112PDK20.41117069
113CDK80.41029638
114SIK10.40337505
115MAPKAPK20.40041266
116MAP3K30.37783377
117CSNK1E0.37015979
118DAPK30.36763042
119MELK0.36434788
120EIF2AK20.36180354
121MAP3K10.35821122
122CCNB10.35648053
123PDGFRA0.35466355
124ILK0.34667276
125CSF1R0.34282728
126FGFR10.34250805
127IRAK40.33917593
128CHUK0.33447143
129MAPK110.31422858
130ICK0.30490158
131TYK20.30425057
132IKBKB0.30182165
133RPS6KA10.29910110

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.64016610
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.76417615
3Mismatch repair_Homo sapiens_hsa034303.75659410
4Ribosome_Homo sapiens_hsa030103.43518174
5Spliceosome_Homo sapiens_hsa030403.16490276
6RNA polymerase_Homo sapiens_hsa030203.05752910
7One carbon pool by folate_Homo sapiens_hsa006703.03640534
8RNA transport_Homo sapiens_hsa030133.03174587
9Base excision repair_Homo sapiens_hsa034102.89827831
10Proteasome_Homo sapiens_hsa030502.83841026
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.73516226
12Homologous recombination_Homo sapiens_hsa034402.52924464
13Nucleotide excision repair_Homo sapiens_hsa034202.46302083
14Pyrimidine metabolism_Homo sapiens_hsa002402.40276903
15Cell cycle_Homo sapiens_hsa041102.37826025
16Fanconi anemia pathway_Homo sapiens_hsa034601.73700842
17Non-homologous end-joining_Homo sapiens_hsa034501.66871136
18RNA degradation_Homo sapiens_hsa030181.64616885
19Sulfur relay system_Homo sapiens_hsa041221.61406104
20Other glycan degradation_Homo sapiens_hsa005111.59232230
21p53 signaling pathway_Homo sapiens_hsa041151.56099207
22mRNA surveillance pathway_Homo sapiens_hsa030151.48853578
23Selenocompound metabolism_Homo sapiens_hsa004501.42697251
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.37790767
25Folate biosynthesis_Homo sapiens_hsa007901.36650142
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.32776441
27Basal transcription factors_Homo sapiens_hsa030221.31170992
28Biosynthesis of amino acids_Homo sapiens_hsa012301.29164346
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21599646
30Pentose phosphate pathway_Homo sapiens_hsa000301.21515937
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.15093584
32Epstein-Barr virus infection_Homo sapiens_hsa051691.11755006
33Purine metabolism_Homo sapiens_hsa002301.09347692
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06062753
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03665843
36Vitamin B6 metabolism_Homo sapiens_hsa007501.00853846
37Antigen processing and presentation_Homo sapiens_hsa046120.96977241
38Herpes simplex infection_Homo sapiens_hsa051680.90315606
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89757441
40Viral carcinogenesis_Homo sapiens_hsa052030.89698539
41Systemic lupus erythematosus_Homo sapiens_hsa053220.89171573
42Fatty acid elongation_Homo sapiens_hsa000620.81331757
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80710366
44Non-small cell lung cancer_Homo sapiens_hsa052230.79180733
45Carbon metabolism_Homo sapiens_hsa012000.78377418
46B cell receptor signaling pathway_Homo sapiens_hsa046620.76890872
47Pancreatic cancer_Homo sapiens_hsa052120.74643400
48Thyroid cancer_Homo sapiens_hsa052160.74304404
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73361053
50HTLV-I infection_Homo sapiens_hsa051660.72315405
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72264201
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71727256
53Glutathione metabolism_Homo sapiens_hsa004800.65185763
54Primary immunodeficiency_Homo sapiens_hsa053400.63729330
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61357753
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58931701
57Legionellosis_Homo sapiens_hsa051340.58491192
58Small cell lung cancer_Homo sapiens_hsa052220.57570015
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56378170
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55501193
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.54414476
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53639017
63Apoptosis_Homo sapiens_hsa042100.51347379
64Sulfur metabolism_Homo sapiens_hsa009200.51209442
65Fructose and mannose metabolism_Homo sapiens_hsa000510.49890791
66MicroRNAs in cancer_Homo sapiens_hsa052060.49867634
67Acute myeloid leukemia_Homo sapiens_hsa052210.48321622
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46917598
69Oocyte meiosis_Homo sapiens_hsa041140.45862157
70Bladder cancer_Homo sapiens_hsa052190.45623038
71Salmonella infection_Homo sapiens_hsa051320.43516815
72Chronic myeloid leukemia_Homo sapiens_hsa052200.42913404
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.42734067
74Galactose metabolism_Homo sapiens_hsa000520.42423279
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42076328
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40926678
77Notch signaling pathway_Homo sapiens_hsa043300.39410391
78Measles_Homo sapiens_hsa051620.38601191
79Shigellosis_Homo sapiens_hsa051310.37423288
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.37249836
81N-Glycan biosynthesis_Homo sapiens_hsa005100.35941691
82Hepatitis C_Homo sapiens_hsa051600.35845857
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34985719
84Lysine degradation_Homo sapiens_hsa003100.34879312
85Parkinsons disease_Homo sapiens_hsa050120.34607696
86Lysosome_Homo sapiens_hsa041420.34051626
87Hepatitis B_Homo sapiens_hsa051610.33644747
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32973862
89Arginine and proline metabolism_Homo sapiens_hsa003300.32680337
90Prion diseases_Homo sapiens_hsa050200.31818513
91Huntingtons disease_Homo sapiens_hsa050160.31207245
92Allograft rejection_Homo sapiens_hsa053300.30926241
93Leishmaniasis_Homo sapiens_hsa051400.30237266
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29981277
95Proteoglycans in cancer_Homo sapiens_hsa052050.29304598
96Vibrio cholerae infection_Homo sapiens_hsa051100.27479915
97VEGF signaling pathway_Homo sapiens_hsa043700.27057325
98Toxoplasmosis_Homo sapiens_hsa051450.26971388
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26909204
100TNF signaling pathway_Homo sapiens_hsa046680.26498994
101Colorectal cancer_Homo sapiens_hsa052100.24974284
102Basal cell carcinoma_Homo sapiens_hsa052170.24883481
103Protein export_Homo sapiens_hsa030600.24003396
104TGF-beta signaling pathway_Homo sapiens_hsa043500.23384494
105Hippo signaling pathway_Homo sapiens_hsa043900.23023500
106Metabolic pathways_Homo sapiens_hsa011000.22840488
107Renin-angiotensin system_Homo sapiens_hsa046140.22398592
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21672309
109HIF-1 signaling pathway_Homo sapiens_hsa040660.20588778
110mTOR signaling pathway_Homo sapiens_hsa041500.19777654
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.19093715
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19034813
113Influenza A_Homo sapiens_hsa051640.18852015
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.18018202
115Hematopoietic cell lineage_Homo sapiens_hsa046400.17369823
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.15682002
117Viral myocarditis_Homo sapiens_hsa054160.15480579
118Pathways in cancer_Homo sapiens_hsa052000.13277104
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.12399342
120Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.12368053
121Vitamin digestion and absorption_Homo sapiens_hsa049770.10578164
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.09241256
123Pyruvate metabolism_Homo sapiens_hsa006200.09065790
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.08842085

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