WDR5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)6.98708001
2maintenance of protein location in nucleus (GO:0051457)6.82638872
3protein localization to kinetochore (GO:0034501)6.50459789
4regulation of mammary gland epithelial cell proliferation (GO:0033599)6.46009448
5negative regulation of epidermis development (GO:0045683)6.40623298
6somite rostral/caudal axis specification (GO:0032525)6.40315043
7DNA unwinding involved in DNA replication (GO:0006268)6.22498644
8negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.21717835
9regulation of nuclear cell cycle DNA replication (GO:0033262)6.14986217
10regulation of telomere maintenance via telomerase (GO:0032210)6.02279727
11regulation of response to osmotic stress (GO:0047484)5.88540911
12negative regulation of telomerase activity (GO:0051974)5.76945548
13negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.65170684
14negative regulation of cell cycle G2/M phase transition (GO:1902750)5.63834398
15histone H4-K12 acetylation (GO:0043983)5.60858575
16rRNA transcription (GO:0009303)5.56971774
17muscle organ morphogenesis (GO:0048644)5.49114873
18mitotic sister chromatid segregation (GO:0000070)5.24759720
19negative regulation of epidermal cell differentiation (GO:0045605)5.01894831
20regulation of MHC class I biosynthetic process (GO:0045343)5.00552236
21heterochromatin organization (GO:0070828)4.95955376
22notochord development (GO:0030903)4.89043315
23protein localization to chromosome, centromeric region (GO:0071459)4.82607495
24DNA replication-dependent nucleosome organization (GO:0034723)4.74681810
25DNA replication-dependent nucleosome assembly (GO:0006335)4.74681810
26rRNA methylation (GO:0031167)4.74125632
27positive regulation of DNA-dependent DNA replication (GO:2000105)4.62953945
28DNA strand elongation involved in DNA replication (GO:0006271)4.57192200
29regulation of translational fidelity (GO:0006450)4.55953187
30regulation of cilium movement (GO:0003352)4.55635752
31nuclear pore complex assembly (GO:0051292)4.55192791
32hormone catabolic process (GO:0042447)4.49331567
33DNA strand elongation (GO:0022616)4.49219090
34cytidine catabolic process (GO:0006216)4.47378003
35cytidine deamination (GO:0009972)4.47378003
36cytidine metabolic process (GO:0046087)4.47378003
37chromatin assembly (GO:0031497)4.42567375
38rRNA modification (GO:0000154)4.42497748
39proline biosynthetic process (GO:0006561)4.42285037
40negative regulation of telomere maintenance (GO:0032205)4.42115777
41phenol-containing compound catabolic process (GO:0019336)4.39981132
42sister chromatid segregation (GO:0000819)4.39567543
43regulation of translation in response to stress (GO:0043555)4.37219047
44primitive streak formation (GO:0090009)4.29302892
45DNA replication checkpoint (GO:0000076)4.29069841
46regulation of apoptotic process involved in morphogenesis (GO:1902337)4.27910628
47response to dietary excess (GO:0002021)4.26349183
48interferon-gamma production (GO:0032609)4.19543523
49DNA replication initiation (GO:0006270)4.17479175
50branching involved in mammary gland duct morphogenesis (GO:0060444)4.15944715
51protein complex localization (GO:0031503)4.12971822
52nucleoside transmembrane transport (GO:1901642)4.12513984
53negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.12282528
54establishment of integrated proviral latency (GO:0075713)4.10799967
55quinone metabolic process (GO:1901661)4.04226205
56nuclear pore organization (GO:0006999)4.03363054
57coenzyme catabolic process (GO:0009109)3.97019555
58peptidyl-arginine omega-N-methylation (GO:0035247)3.91138466
59cellular protein complex localization (GO:0034629)3.83953507
60cell fate commitment involved in formation of primary germ layer (GO:0060795)3.83396281
61telomere maintenance via semi-conservative replication (GO:0032201)3.82420445
62maintenance of protein localization in organelle (GO:0072595)3.79981886
63Golgi transport vesicle coating (GO:0048200)3.75565693
64COPI coating of Golgi vesicle (GO:0048205)3.75565693
65pre-miRNA processing (GO:0031054)3.72174077
66spliceosomal tri-snRNP complex assembly (GO:0000244)3.70835490
67intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.67590700
68intestinal epithelial cell development (GO:0060576)3.66285238
69cullin deneddylation (GO:0010388)3.64955418
70cellular modified amino acid catabolic process (GO:0042219)3.63589108
71regulation of telomere maintenance (GO:0032204)3.60408570
72negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.56933398
73regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.56621699
74histone arginine methylation (GO:0034969)3.55196226
75mitotic metaphase plate congression (GO:0007080)3.54029033
76positive regulation of protein deacetylation (GO:0090312)3.53190144
77regulation of telomerase activity (GO:0051972)3.52354575
78mRNA stabilization (GO:0048255)3.50232942
79RNA stabilization (GO:0043489)3.50232942
80mitochondrion distribution (GO:0048311)3.50142187
81mitotic sister chromatid cohesion (GO:0007064)3.46877832
82ribosome biogenesis (GO:0042254)3.45042839
83regulation of posttranscriptional gene silencing (GO:0060147)3.42793951
84regulation of gene silencing by miRNA (GO:0060964)3.42793951
85regulation of gene silencing by RNA (GO:0060966)3.42793951
86pore complex assembly (GO:0046931)3.40380054
87ribosomal small subunit biogenesis (GO:0042274)3.40245933
88retinoic acid receptor signaling pathway (GO:0048384)3.39812839
89negative regulation of mRNA processing (GO:0050686)3.39537503
90mitotic nuclear envelope disassembly (GO:0007077)3.39461624
91GDP-mannose metabolic process (GO:0019673)3.36935859
92transcription from mitochondrial promoter (GO:0006390)3.34282052
93epoxygenase P450 pathway (GO:0019373)3.34032546
94regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.31750579
95maternal placenta development (GO:0001893)3.31126263
96DNA damage response, detection of DNA damage (GO:0042769)3.30114977
97vitamin A metabolic process (GO:0006776)3.28983701
98cardiovascular system development (GO:0072358)3.28779356
99regulation of translational termination (GO:0006449)3.28476295
100peptidyl-arginine methylation (GO:0018216)3.28065105
101peptidyl-arginine N-methylation (GO:0035246)3.28065105
102nucleobase-containing small molecule interconversion (GO:0015949)3.28018291
103mitotic chromosome condensation (GO:0007076)3.27368629
104DNA duplex unwinding (GO:0032508)3.27005034
105intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.25096688
106negative regulation of mRNA metabolic process (GO:1903312)3.24756397
107trophectodermal cell differentiation (GO:0001829)3.24457093
108protein deneddylation (GO:0000338)3.23920808
109ribosome assembly (GO:0042255)3.23840601
110bone trabecula formation (GO:0060346)3.23595388
111membrane disassembly (GO:0030397)3.23208312
112nuclear envelope disassembly (GO:0051081)3.23208312
113DNA geometric change (GO:0032392)3.22467682
114DNA topological change (GO:0006265)3.20092090
115formation of translation preinitiation complex (GO:0001731)3.19895519
116microtubule severing (GO:0051013)3.19134192
117establishment of viral latency (GO:0019043)3.16839269
118apoptotic DNA fragmentation (GO:0006309)3.16509134
119chromosome condensation (GO:0030261)3.15204049
120* histone H4-K5 acetylation (GO:0043981)3.12883498
121* histone H4-K8 acetylation (GO:0043982)3.12883498
122regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.12058135
123telomere maintenance via recombination (GO:0000722)3.11475796
124positive regulation of histone deacetylation (GO:0031065)3.09810981
125pseudouridine synthesis (GO:0001522)3.08523867
126phagocytosis, recognition (GO:0006910)3.07867032
127protein polyglutamylation (GO:0018095)3.07641900
128L-serine metabolic process (GO:0006563)3.07559444
129pyrimidine ribonucleoside catabolic process (GO:0046133)3.07537775
130negative regulation of RNA splicing (GO:0033119)3.07498789
131positive regulation of chromosome segregation (GO:0051984)3.06800950
132nucleoside transport (GO:0015858)3.03546823
133arachidonic acid secretion (GO:0050482)3.03247087
134icosanoid secretion (GO:0032309)3.03247087
135regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.02532691
136IMP biosynthetic process (GO:0006188)2.98459769
137pentose-phosphate shunt (GO:0006098)2.98269285
138folic acid-containing compound biosynthetic process (GO:0009396)2.95410590
139regulation of RNA export from nucleus (GO:0046831)2.92784188
140ribonucleoprotein complex biogenesis (GO:0022613)2.92432651
141mitotic recombination (GO:0006312)2.91954436
142maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.91128114
143protein export from nucleus (GO:0006611)2.89898023
1443-UTR-mediated mRNA stabilization (GO:0070935)2.89556014
145regulation of sister chromatid cohesion (GO:0007063)2.89057871
146DNA conformation change (GO:0071103)2.88698964
147proline metabolic process (GO:0006560)2.88542456
148protein-DNA complex disassembly (GO:0032986)2.88394036
149nucleosome disassembly (GO:0006337)2.88394036
150protein retention in ER lumen (GO:0006621)2.88305801
151nuclear envelope organization (GO:0006998)2.85991843
152mitochondrial fusion (GO:0008053)2.83036401
153apoptotic process involved in morphogenesis (GO:0060561)2.82535090
154regulation of mitotic spindle organization (GO:0060236)2.81552801
155maturation of SSU-rRNA (GO:0030490)2.80545043
156regulation of spindle organization (GO:0090224)2.79000520
157IMP metabolic process (GO:0046040)2.77372229
158nuclear envelope reassembly (GO:0031468)2.73778088
159mitotic nuclear envelope reassembly (GO:0007084)2.73778088
160positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.73052351
161NADPH regeneration (GO:0006740)2.72089339
162protein maturation by protein folding (GO:0022417)2.70165207
163DNA packaging (GO:0006323)2.66631224
164folic acid metabolic process (GO:0046655)2.65609286
165regulation of nucleobase-containing compound transport (GO:0032239)2.64066580
166adherens junction assembly (GO:0034333)2.63621117
167viral mRNA export from host cell nucleus (GO:0046784)2.62717800
168metaphase plate congression (GO:0051310)2.61953319
169snRNA metabolic process (GO:0016073)2.61628077
170DNA synthesis involved in DNA repair (GO:0000731)2.61512916
171retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.61497539
172focal adhesion assembly (GO:0048041)2.58954283
173cell-substrate adherens junction assembly (GO:0007045)2.58954283
174activation of Rac GTPase activity (GO:0032863)2.57003940
175glucose catabolic process (GO:0006007)2.55897959
176mRNA transport (GO:0051028)2.54938817
177doxorubicin metabolic process (GO:0044598)10.7838822
178daunorubicin metabolic process (GO:0044597)10.7838822
179polyketide metabolic process (GO:0030638)10.7838822

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.29844754
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.29844754
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.29844754
4BP1_19119308_ChIP-ChIP_Hs578T_Human6.18081046
5E2F7_22180533_ChIP-Seq_HELA_Human4.99103140
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.17298035
7NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.22176336
8TP63_19390658_ChIP-ChIP_HaCaT_Human3.13089565
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.07878146
10POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.93016005
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.85823171
12SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.82591231
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.58038538
14TCF3_18692474_ChIP-Seq_MESCs_Mouse2.50835082
15TCF3_18692474_ChIP-Seq_MEFs_Mouse2.48017597
16SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.43653012
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.41732365
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.28480155
19ZNF263_19887448_ChIP-Seq_K562_Human2.04769085
20NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.03936385
21* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.02895519
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.98369808
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.94803655
24VDR_21846776_ChIP-Seq_THP-1_Human1.92407838
25DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.92364161
26THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92276439
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91115211
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.89947705
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.89139141
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.87914832
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87806434
32* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.87100344
33NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.82704993
34KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.79937171
35CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.79467393
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.77780766
37POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.76705966
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73549721
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70504679
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.70244185
41HIF1A_21447827_ChIP-Seq_MCF-7_Human1.69777547
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69667075
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.66923870
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65764122
45DCP1A_22483619_ChIP-Seq_HELA_Human1.64794625
46* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54662672
47* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.54563204
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50684687
49* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.50666120
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50112371
51* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.49762471
52* LXR_22292898_ChIP-Seq_THP-1_Human1.48470482
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48072436
54TTF2_22483619_ChIP-Seq_HELA_Human1.46564871
55NANOG_18692474_ChIP-Seq_MEFs_Mouse1.45178963
56* GABP_19822575_ChIP-Seq_HepG2_Human1.44185706
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43229213
58* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42531141
59* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.42185228
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41522663
61POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.41225400
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40369758
63* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.39874233
64MYC_22102868_ChIP-Seq_BL_Human1.38783236
65* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.38552716
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.38066653
67MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35135717
68OCT4_18692474_ChIP-Seq_MEFs_Mouse1.32629935
69PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.31215970
70CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.31109752
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30537753
72* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30444760
73ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27488408
74E2F1_17053090_ChIP-ChIP_MCF-7_Human1.26903881
75CLOCK_20551151_ChIP-Seq_293T_Human1.26273006
76SOX2_18692474_ChIP-Seq_MESCs_Mouse1.26015613
77* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24780036
78* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23671509
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.23092974
80CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22400137
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.22395462
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22137517
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20733002
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20248361
85SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19953853
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19382883
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18720645
88NANOG_16518401_ChIP-PET_MESCs_Mouse1.15942926
89CDX2_20551321_ChIP-Seq_CACO-2_Human1.13671323
90RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13029354
91SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12740062
92ATF3_27146783_Chip-Seq_COLON_Human1.12302572
93KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11102264
94* IRF1_19129219_ChIP-ChIP_H3396_Human1.09050800
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08343820
96NANOG_21062744_ChIP-ChIP_HESCs_Human1.08152731
97NANOG_16153702_ChIP-ChIP_HESCs_Human1.07154361
98* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06588582
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05082123
100SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05033231
101P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04143018
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03693977
103ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03560365
104CHD1_26751641_Chip-Seq_LNCaP_Human1.02393943
105CIITA_25753668_ChIP-Seq_RAJI_Human1.02288090
106P68_20966046_ChIP-Seq_HELA_Human1.02251086
107KDM2B_26808549_Chip-Seq_DND41_Human1.02031279
108TFEB_21752829_ChIP-Seq_HELA_Human1.01442795
109NCOR1_26117541_ChIP-Seq_K562_Human0.98801156
110TP53_22127205_ChIP-Seq_IMR90_Human0.96645860
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95971744
112SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95518455
113SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95348290
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94651928
115EST1_17652178_ChIP-ChIP_JURKAT_Human0.94578853
116TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94571308
117EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94195220
118TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93251808
119ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92964372
120POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91020580
121KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90168754
122E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90139446
123KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89388080
124POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88067041
125* TCF7_22412390_ChIP-Seq_EML_Mouse0.85771220
126ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.83546906
127SCL_19346495_ChIP-Seq_HPC-7_Human0.82387251
128KAP1_27257070_Chip-Seq_ESCs_Mouse0.81092681
129AR_21909140_ChIP-Seq_LNCAP_Human0.79949591
130TBX3_20139965_ChIP-Seq_ESCs_Mouse0.77711202
131KDM2B_26808549_Chip-Seq_SUP-B15_Human0.77227237
132EGR1_19374776_ChIP-ChIP_THP-1_Human0.77076040
133TBX3_20139965_ChIP-Seq_MESCs_Mouse0.76346876
134TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.76260236
135KDM5A_27292631_Chip-Seq_BREAST_Human0.75516200
136* FOXP3_21729870_ChIP-Seq_TREG_Human0.74705667
137PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74121415
138YY1_22570637_ChIP-Seq_MALME-3M_Human0.73815693
139ELK3_25401928_ChIP-Seq_HUVEC_Human0.73277909
140XRN2_22483619_ChIP-Seq_HELA_Human0.72661725
141CTCF_21964334_Chip-Seq_Bcells_Human0.70922402
142ESR1_15608294_ChIP-ChIP_MCF-7_Human0.70655321
143MYCN_18555785_ChIP-Seq_MESCs_Mouse0.70386995
144SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.70274018
145NELFA_20434984_ChIP-Seq_ESCs_Mouse0.69921355
146SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.68839978
147SOX2_16153702_ChIP-ChIP_HESCs_Human0.67275008
148STAT3_18555785_ChIP-Seq_MESCs_Mouse0.67132689
149RACK7_27058665_Chip-Seq_MCF-7_Human0.66905892
150* SMC4_20622854_ChIP-Seq_HELA_Human0.66041160
151JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.66016802
152ETS1_20019798_ChIP-Seq_JURKAT_Human0.63235839

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.68226452
2MP0002254_reproductive_system_inflammat4.60964149
3MP0004264_abnormal_extraembryonic_tissu4.38741123
4MP0006292_abnormal_olfactory_placode4.29141229
5MP0003890_abnormal_embryonic-extraembry3.54081352
6MP0008057_abnormal_DNA_replication3.30044650
7MP0005499_abnormal_olfactory_system3.21651870
8MP0005394_taste/olfaction_phenotype3.21651870
9MP0005075_abnormal_melanosome_morpholog3.17583738
10MP0004858_abnormal_nervous_system3.08476573
11MP0004957_abnormal_blastocyst_morpholog2.96355980
12MP0003122_maternal_imprinting2.90535570
13MP0002877_abnormal_melanocyte_morpholog2.72633490
14MP0002332_abnormal_exercise_endurance2.63113302
15MP0003705_abnormal_hypodermis_morpholog2.52293340
16MP0005076_abnormal_cell_differentiation2.44700995
17MP0005257_abnormal_intraocular_pressure2.40760658
18MP0003121_genomic_imprinting2.40301588
19MP0010234_abnormal_vibrissa_follicle2.34661659
20MP0004233_abnormal_muscle_weight2.31508941
21MP0010352_gastrointestinal_tract_polyps2.28278004
22MP0006035_abnormal_mitochondrial_morpho2.26797543
23MP0004185_abnormal_adipocyte_glucose2.20734888
24MP0005451_abnormal_body_composition2.18154377
25MP0000537_abnormal_urethra_morphology2.16961508
26MP0002653_abnormal_ependyma_morphology2.16856822
27MP0005380_embryogenesis_phenotype1.95244969
28MP0001672_abnormal_embryogenesis/_devel1.95244969
29MP0003938_abnormal_ear_development1.87981665
30MP0000678_abnormal_parathyroid_gland1.87084893
31MP0002796_impaired_skin_barrier1.86876832
32MP0009672_abnormal_birth_weight1.86112391
33MP0008058_abnormal_DNA_repair1.85348114
34MP0003566_abnormal_cell_adhesion1.83445274
35MP0002088_abnormal_embryonic_growth/wei1.81300752
36MP0003123_paternal_imprinting1.80043534
37MP0003984_embryonic_growth_retardation1.79696677
38MP0005501_abnormal_skin_physiology1.78108202
39MP0008260_abnormal_autophagy1.71868924
40MP0002277_abnormal_respiratory_mucosa1.63881705
41MP0003077_abnormal_cell_cycle1.62933080
42MP0001293_anophthalmia1.62318749
43MP0010030_abnormal_orbit_morphology1.61428537
44MP0008961_abnormal_basal_metabolism1.59837170
45MP0002127_abnormal_cardiovascular_syste1.59536165
46MP0001849_ear_inflammation1.59192816
47MP0000350_abnormal_cell_proliferation1.57238644
48MP0003183_abnormal_peptide_metabolism1.56571578
49MP0003111_abnormal_nucleus_morphology1.46114410
50MP0002092_abnormal_eye_morphology1.42533980
51MP0002932_abnormal_joint_morphology1.41741022
52MP0002086_abnormal_extraembryonic_tissu1.40190413
53MP0006082_CNS_inflammation1.36571132
54MP0002085_abnormal_embryonic_tissue1.34869630
55MP0010307_abnormal_tumor_latency1.34001992
56MP0002396_abnormal_hematopoietic_system1.33959485
57MP0000762_abnormal_tongue_morphology1.32879605
58MP0005623_abnormal_meninges_morphology1.30931412
59MP0001346_abnormal_lacrimal_gland1.30870156
60MP0008789_abnormal_olfactory_epithelium1.28067516
61MP0003453_abnormal_keratinocyte_physiol1.26725131
62MP0005266_abnormal_metabolism1.26224952
63MP0010094_abnormal_chromosome_stability1.25770714
64MP0000049_abnormal_middle_ear1.24989185
65MP0000733_abnormal_muscle_development1.22716056
66MP0002084_abnormal_developmental_patter1.20768139
67MP0002233_abnormal_nose_morphology1.18390295
68MP0000566_synostosis1.17228192
69MP0005058_abnormal_lysosome_morphology1.16705976
70MP0001661_extended_life_span1.15593385
71MP0009053_abnormal_anal_canal1.15265257
72MP0004808_abnormal_hematopoietic_stem1.15047512
73MP0002089_abnormal_postnatal_growth/wei1.15023323
74MP0002060_abnormal_skin_morphology1.13666720
75MP0005621_abnormal_cell_physiology1.12709751
76MP0003941_abnormal_skin_development1.11933356
77MP0002697_abnormal_eye_size1.11454619
78MP0003315_abnormal_perineum_morphology1.09954091
79MP0002114_abnormal_axial_skeleton1.09706255
80MP0003119_abnormal_digestive_system1.09489951
81MP0004133_heterotaxia1.09466166
82MP0000428_abnormal_craniofacial_morphol1.08863375
83MP0001730_embryonic_growth_arrest1.06696198
84MP0004197_abnormal_fetal_growth/weight/1.04972284
85MP0000432_abnormal_head_morphology1.01783295
86MP0004043_abnormal_pH_regulation1.01065429
87MP0002970_abnormal_white_adipose1.01002389
88MP0000490_abnormal_crypts_of1.00879838
89MP0003283_abnormal_digestive_organ1.00851563
90MP0000579_abnormal_nail_morphology0.99218393
91MP0005248_abnormal_Harderian_gland0.98633580
92MP0001348_abnormal_lacrimal_gland0.98377759
93MP0000313_abnormal_cell_death0.98027247
94MP0003935_abnormal_craniofacial_develop0.97818403
95MP0001697_abnormal_embryo_size0.96855417
96MP0000747_muscle_weakness0.96338784
97MP0009278_abnormal_bone_marrow0.94765400
98MP0000003_abnormal_adipose_tissue0.94571546
99MP0008770_decreased_survivor_rate0.94336686
100MP0008932_abnormal_embryonic_tissue0.94298903
101MP0003221_abnormal_cardiomyocyte_apopto0.94069374
102MP0003755_abnormal_palate_morphology0.93813222
103MP0004381_abnormal_hair_follicle0.93790353
104MP0003115_abnormal_respiratory_system0.93028810
105MP0000467_abnormal_esophagus_morphology0.92994878
106MP0003693_abnormal_embryo_hatching0.91464075
107MP0000462_abnormal_digestive_system0.91429406
108MP0010630_abnormal_cardiac_muscle0.89768774
109MP0002080_prenatal_lethality0.89696991
110MP0000858_altered_metastatic_potential0.89570614
111MP0005666_abnormal_adipose_tissue0.89059549
112MP0003787_abnormal_imprinting0.88974778
113MP0004272_abnormal_basement_membrane0.87413131
114MP0001216_abnormal_epidermal_layer0.87204172
115MP0005391_vision/eye_phenotype0.85947815
116MP0001915_intracranial_hemorrhage0.84636702
117MP0002132_abnormal_respiratory_system0.84263036
118MP0008007_abnormal_cellular_replicative0.83940679
119MP0003385_abnormal_body_wall0.83905145
120MP0000751_myopathy0.83293593
121MP0009333_abnormal_splenocyte_physiolog0.83131990
122MP0003137_abnormal_impulse_conducting0.82654051
123MP0004782_abnormal_surfactant_physiolog0.82534842
124MP0003942_abnormal_urinary_system0.81644763
125MP0002925_abnormal_cardiovascular_devel0.81526315
126MP0000759_abnormal_skeletal_muscle0.81522017
127MP0000750_abnormal_muscle_regeneration0.78322923
128MP0004087_abnormal_muscle_fiber0.77754686
129MP0002009_preneoplasia0.77750802
130MP0005508_abnormal_skeleton_morphology0.76776047
131MP0002249_abnormal_larynx_morphology0.76293065
132MP0001727_abnormal_embryo_implantation0.74114101
133MP0005023_abnormal_wound_healing0.73413680
134MP0008438_abnormal_cutaneous_collagen0.73411144
135MP0009703_decreased_birth_body0.73255960
136MP0001881_abnormal_mammary_gland0.72443060
137MP0002269_muscular_atrophy0.70937592
138MP0000358_abnormal_cell_content/0.70517864
139MP0002116_abnormal_craniofacial_bone0.69872694
140MP0003786_premature_aging0.68293399
141MP0002751_abnormal_autonomic_nervous0.67827205
142MP0003937_abnormal_limbs/digits/tail_de0.66623631
143MP0001286_abnormal_eye_development0.65712776
144MP0002098_abnormal_vibrissa_morphology0.64633986
145MP0005384_cellular_phenotype0.58545719
146MP0002111_abnormal_tail_morphology0.58203736
147MP0002081_perinatal_lethality0.57100600
148MP0002019_abnormal_tumor_incidence0.56584397
149MP0000749_muscle_degeneration0.55480937
150MP0003448_altered_tumor_morphology0.53396695
151MP0000377_abnormal_hair_follicle0.53389723
152MP0003861_abnormal_nervous_system0.51609480
153MP0005197_abnormal_uvea_morphology0.50945728

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.51973893
2Hypochromic microcytic anemia (HP:0004840)6.26383620
3Hepatoblastoma (HP:0002884)5.59999444
4Multiple enchondromatosis (HP:0005701)5.49696912
5Abnormality of the lower motor neuron (HP:0002366)4.84256627
6Rib fusion (HP:0000902)4.74795381
7Ependymoma (HP:0002888)4.53877556
8Neoplasm of striated muscle (HP:0009728)3.87476439
9Nephroblastoma (Wilms tumor) (HP:0002667)3.80428782
10Rhabdomyosarcoma (HP:0002859)3.75058995
11Hyperacusis (HP:0010780)3.74903876
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.71465260
13Embryonal renal neoplasm (HP:0011794)3.52790803
14Testicular atrophy (HP:0000029)3.50871982
15Aplasia/Hypoplasia of the fovea (HP:0008060)3.36087602
16Hypoplasia of the fovea (HP:0007750)3.36087602
17Fused cervical vertebrae (HP:0002949)3.27035017
18Rectovaginal fistula (HP:0000143)3.24565375
19Rectal fistula (HP:0100590)3.24565375
20Abnormality of the astrocytes (HP:0100707)3.22945955
21Astrocytoma (HP:0009592)3.22945955
22Chromsome breakage (HP:0040012)3.17283221
23Ragged-red muscle fibers (HP:0003200)3.15754879
24Abnormality of the salivary glands (HP:0010286)3.12881097
25Partial duplication of thumb phalanx (HP:0009944)3.10684811
26Hyperinsulinemic hypoglycemia (HP:0000825)3.03452730
27Trismus (HP:0000211)3.01204575
28Amyotrophic lateral sclerosis (HP:0007354)2.99234552
29Aplasia/hypoplasia of the humerus (HP:0006507)2.96576426
30Bifid tongue (HP:0010297)2.95761998
31Insomnia (HP:0100785)2.94636549
32Abnormal lung lobation (HP:0002101)2.94388022
33Abnormal cartilage morphology (HP:0002763)2.92068636
34Short humerus (HP:0005792)2.91715260
35Intestinal fistula (HP:0100819)2.91402096
36Horizontal nystagmus (HP:0000666)2.85722827
37Anomalous pulmonary venous return (HP:0010772)2.83043133
38Vaginal fistula (HP:0004320)2.81851418
39Selective tooth agenesis (HP:0001592)2.77577380
40Partial duplication of the phalanx of hand (HP:0009999)2.71691951
41Increased nuchal translucency (HP:0010880)2.67222638
42Hypochromic anemia (HP:0001931)2.66635875
43Preauricular skin tag (HP:0000384)2.66511799
44Reduced antithrombin III activity (HP:0001976)2.65961944
45Shawl scrotum (HP:0000049)2.53676656
46Meckel diverticulum (HP:0002245)2.51683874
47Abnormality of the fovea (HP:0000493)2.50467378
48Impulsivity (HP:0100710)2.49157196
49Deviation of the thumb (HP:0009603)2.48506762
50Achilles tendon contracture (HP:0001771)2.47949440
51Periauricular skin pits (HP:0100277)2.47693599
52Preauricular pit (HP:0004467)2.47693599
53Asymmetry of the thorax (HP:0001555)2.46806865
54Progressive muscle weakness (HP:0003323)2.46203564
55Pendular nystagmus (HP:0012043)2.44743955
56Supernumerary spleens (HP:0009799)2.43633758
57Proximal placement of thumb (HP:0009623)2.43371009
58Large earlobe (HP:0009748)2.43309734
59Abnormality of the pulmonary veins (HP:0011718)2.40610619
60Glioma (HP:0009733)2.40038783
61Generalized hypotonia (HP:0001290)2.37111428
62Long palpebral fissure (HP:0000637)2.36885033
63Abnormality of the umbilical cord (HP:0010881)2.36028193
64Premature rupture of membranes (HP:0001788)2.35967787
65Skin tags (HP:0010609)2.35772365
66Abnormality of the ileum (HP:0001549)2.35495555
67Centrally nucleated skeletal muscle fibers (HP:0003687)2.34264609
68Abnormality of chromosome segregation (HP:0002916)2.33101636
69Aplasia/Hypoplasia of the uvula (HP:0010293)2.32264920
70Ulnar bowing (HP:0003031)2.32006891
71Tetraplegia (HP:0002445)2.31662614
72Overriding aorta (HP:0002623)2.30596078
73Abnormality of the phalanges of the hallux (HP:0010057)2.29534649
74Nasolacrimal duct obstruction (HP:0000579)2.29505419
75Sensory axonal neuropathy (HP:0003390)2.28628098
76Increased connective tissue (HP:0009025)2.23232927
77Aplasia/Hypoplasia of the macula (HP:0008059)2.21289572
78Glossoptosis (HP:0000162)2.20388490
79Short 5th finger (HP:0009237)2.19967764
80Distal lower limb amyotrophy (HP:0008944)2.19748238
81Tongue fasciculations (HP:0001308)2.18993049
82Broad distal phalanx of finger (HP:0009836)2.18509998
83Upper motor neuron abnormality (HP:0002127)2.15897690
84Difficulty running (HP:0009046)2.15893436
85Abnormality of the distal phalanges of the toes (HP:0010182)2.15662391
86Abnormality of the Achilles tendon (HP:0005109)2.15545601
87Renal duplication (HP:0000075)2.14555500
88Abnormality of small intestinal villus morphology (HP:0011472)2.14325477
89Villous atrophy (HP:0011473)2.14325477
90Myopathic facies (HP:0002058)2.11893347
91Malignant neoplasm of the central nervous system (HP:0100836)2.11628583
92Hyperventilation (HP:0002883)2.11091261
93Neoplasm of the heart (HP:0100544)2.10116616
94Aplasia/Hypoplasia of the sternum (HP:0006714)2.10025600
95Abnormality of the musculature of the hand (HP:0001421)2.09904571
96Abnormality of the calcaneus (HP:0008364)2.09067469
97Hypopigmentation of the fundus (HP:0007894)2.08649854
98Sparse lateral eyebrow (HP:0005338)2.07982365
99Abnormality of the distal phalanx of the thumb (HP:0009617)2.05456562
100Abnormality of the pubic bones (HP:0003172)2.05454170
101Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.05155059
102Microretrognathia (HP:0000308)2.05131885
103Pseudobulbar signs (HP:0002200)2.04202687
104Dysmetric saccades (HP:0000641)2.03358322
105Premature ovarian failure (HP:0008209)2.02418945
106Elfin facies (HP:0004428)2.02186497
107Ankyloglossia (HP:0010296)2.01507295
108Muscle fibrillation (HP:0010546)1.99123516
109Medulloblastoma (HP:0002885)1.98609114
110Aplasia/Hypoplasia affecting the retina (HP:0008061)1.98488802
111Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.98465423
112Microvesicular hepatic steatosis (HP:0001414)1.97103976
113Supernumerary nipples (HP:0002558)1.95519348
114Skin pits (HP:0100276)1.95310558
115High anterior hairline (HP:0009890)1.95073455
116Small intestinal stenosis (HP:0012848)1.95058819
117Duodenal stenosis (HP:0100867)1.95058819
118Progressive external ophthalmoplegia (HP:0000590)1.94255039
119Atrophy/Degeneration involving motor neurons (HP:0007373)1.93924441
120Hand muscle atrophy (HP:0009130)1.93595542
121Vertebral fusion (HP:0002948)1.93062437
122Embryonal neoplasm (HP:0002898)1.92991394
123Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.92588881
124Birth length less than 3rd percentile (HP:0003561)1.92548184
125Back pain (HP:0003418)1.92418741
126Cheilitis (HP:0100825)1.91105211
127Upper limb muscle weakness (HP:0003484)1.90947729
128Cholecystitis (HP:0001082)1.89623470
129Abnormal gallbladder physiology (HP:0012438)1.89623470
130Disproportionate tall stature (HP:0001519)1.89106270
131Patellar dislocation (HP:0002999)1.89077166
132Reticulocytopenia (HP:0001896)1.85549158
133Atresia of the external auditory canal (HP:0000413)1.84178871
134Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82560381
135Abnormality of reticulocytes (HP:0004312)1.82107013
136Distal upper limb amyotrophy (HP:0007149)1.81409805
137Upper limb amyotrophy (HP:0009129)1.81409805
138Protrusio acetabuli (HP:0003179)1.81135362
139Abnormality of the fetal cardiovascular system (HP:0010948)1.80957431
140Abnormal umbilical cord blood vessels (HP:0011403)1.80957431
141Single umbilical artery (HP:0001195)1.80957431
142Reticulocytosis (HP:0001923)1.80476523
143Broad face (HP:0000283)1.79965309
144Spastic diplegia (HP:0001264)1.79784324
145Rough bone trabeculation (HP:0100670)1.78323478
146Abnormalities of placenta or umbilical cord (HP:0001194)1.77330459
147Urethral obstruction (HP:0000796)1.76414464
148Abnormality of oral frenula (HP:0000190)1.76365732
149Breast hypoplasia (HP:0003187)1.76165588
150Pointed chin (HP:0000307)1.75647077
151Vertebral compression fractures (HP:0002953)1.74548376
152Unilateral renal agenesis (HP:0000122)1.74517379
153Thin ribs (HP:0000883)1.74004017
154Shoulder girdle muscle weakness (HP:0003547)1.73740941
155Pterygium (HP:0001059)1.73726125
156Syringomyelia (HP:0003396)1.73358293
157Spinal cord lesions (HP:0100561)1.73358293
158Generalized amyotrophy (HP:0003700)1.73111662
159Truncus arteriosus (HP:0001660)1.72727438
160Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72431475
161Flat acetabular roof (HP:0003180)1.72428114
162Septate vagina (HP:0001153)1.71320076
163Orthostatic hypotension (HP:0001278)1.70686545
164Advanced eruption of teeth (HP:0006288)1.70412100
165Abnormality of glycolysis (HP:0004366)1.69944619
166Cortical dysplasia (HP:0002539)1.69678907
167Short nail (HP:0001799)1.69429522
168Natal tooth (HP:0000695)1.68601600
169Squamous cell carcinoma (HP:0002860)1.67989173
170Termporal pattern (HP:0011008)1.67252357
171Insidious onset (HP:0003587)1.67252357
172Breech presentation (HP:0001623)1.64718296
173Facial cleft (HP:0002006)1.63720057
174Overlapping toe (HP:0001845)1.62293665
175Calcaneovalgus deformity (HP:0001848)1.60568036
176Duplication of thumb phalanx (HP:0009942)1.58880537
177Shallow orbits (HP:0000586)1.57832538
178Lower limb amyotrophy (HP:0007210)1.56679249
179Abnormality of the thoracic spine (HP:0100711)1.55760558
180Progressive hearing impairment (HP:0001730)1.54843456
181Deep palmar crease (HP:0006191)1.53989230
182Renovascular hypertension (HP:0100817)1.53527326
183Arnold-Chiari malformation (HP:0002308)1.53145451
184Poikiloderma (HP:0001029)1.52256351

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.59803248
2GRK55.18991896
3ERN14.58223728
4GRK64.22814644
5SMG14.14202452
6TRIB33.78155371
7EEF2K3.10012362
8GRK13.08499455
9ADRBK23.03911288
10NME22.95482828
11CSF1R2.92468613
12TTK2.78735390
13TYRO32.73488522
14TGFBR22.66732048
15IRAK32.50305739
16MATK2.38313021
17GRK72.37371115
18MAPK72.36650960
19STK102.29781443
20MOS2.11712312
21SCYL22.00379468
22PBK1.95185762
23WNK11.93925466
24CDK71.67946165
25VRK21.65336926
26EPHA21.50421650
27EIF2AK11.47084008
28NTRK11.45622182
29CAMK41.44422984
30PRKG21.39014359
31ARAF1.34955112
32TSSK61.34089000
33PAK41.33799196
34CHEK21.32062709
35MARK21.22325543
36PKN21.21382698
37MST1R1.20734253
38AKT31.20198727
39PLK11.20086160
40FGFR41.17993993
41TESK11.16226914
42TTN1.16055592
43HIPK21.12604568
44MAP2K41.12508200
45MAP3K101.06296755
46FGFR31.02582554
47ADRBK11.02180000
48PRKD31.00816993
49BRAF0.97466693
50BRSK10.96715807
51KSR20.86613045
52CDC70.84266461
53CDK60.83967924
54CHEK10.83346852
55ALK0.81689282
56CSK0.78475151
57AKT20.78372391
58NEK20.77232817
59LATS20.77002929
60TAF10.75836978
61BRD40.75293135
62MAP2K30.71852200
63RPS6KA40.71660159
64WEE10.71554713
65STK40.70590491
66MAP2K60.69889660
67PIM20.67256069
68BUB10.66967824
69LMTK20.65687380
70CDK90.64638473
71PLK40.64605370
72EIF2AK20.64361143
73MAPK120.63022286
74PASK0.62021368
75MAP3K70.61941876
76MET0.61737728
77MAPK110.61433128
78ILK0.61386871
79CLK10.60907700
80RPS6KB20.59946861
81MTOR0.58058700
82PTK60.56116710
83IRAK20.53639622
84ERBB40.53580132
85STK160.53432947
86CDK20.51981287
87AURKA0.49471878
88NME10.49394110
89PAK20.49214360
90LRRK20.49159343
91DAPK10.48541344
92CDK140.48070171
93CDK40.46917247
94MAP3K130.45553757
95PRKCI0.44885371
96KDR0.43593963
97MAP2K20.40933377
98AURKB0.40734345
99RAF10.39809502
100PLK30.39241468
101LATS10.38741862
102ATM0.37741957
103NEK10.37719526
104IGF1R0.36583336
105RIPK10.36525679
106MKNK10.36478209
107CAMK1D0.36414824
108PAK10.35344257
109MAP3K90.35295194
110PTK20.35293124
111CSNK1E0.34456338
112PDGFRA0.34021419
113ERBB20.33782318
114ITK0.31465978
115DYRK30.30626182
116CDK10.28697356
117MAPK100.27434726
118MAPKAPK30.27195181
119PRKCD0.26747647
120IKBKB0.26341019
121BMX0.24847497
122SRPK10.22426331
123DYRK20.21246891
124MAPK10.21050469
125GSK3B0.20646757
126INSR0.20307557
127MAPK140.20206354
128STK380.19616293
129MAPK40.18726868
130ICK0.18225172
131DDR20.18114604
132TAOK20.16208317
133PRKD20.15733887
134TESK20.15549007
135GSK3A0.15505515
136PRKACG0.14901930
137DYRK1A0.14901121
138CDK150.14786564
139PRKAA10.14737559
140CDK11A0.13639093
141PRKACB0.13618420
142CDK80.13002556
143MAP3K80.12447724
144ATR0.11535680
145CDK180.10823280
146TAOK10.10758053
147SIK10.09289739
148CHUK0.08087771
149PRPF4B0.07906553
150AKT10.07672413
151RPS6KA30.07335511
152MAPKAPK20.07127220

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.51085593
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.83358553
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.46056214
4Fructose and mannose metabolism_Homo sapiens_hsa000513.79413827
5Galactose metabolism_Homo sapiens_hsa000522.56588586
6Arachidonic acid metabolism_Homo sapiens_hsa005902.47828545
7Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.23086329
8RNA transport_Homo sapiens_hsa030132.10514463
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.09585315
10Linoleic acid metabolism_Homo sapiens_hsa005911.99840490
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.88754266
12Pentose and glucuronate interconversions_Homo sapiens_hsa000401.81325784
13DNA replication_Homo sapiens_hsa030301.79775461
14Thyroid cancer_Homo sapiens_hsa052161.69222380
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.67156659
16Fanconi anemia pathway_Homo sapiens_hsa034601.62004556
17mTOR signaling pathway_Homo sapiens_hsa041501.59841654
18Chronic myeloid leukemia_Homo sapiens_hsa052201.56847229
19mRNA surveillance pathway_Homo sapiens_hsa030151.56005930
20Mismatch repair_Homo sapiens_hsa034301.54511224
21One carbon pool by folate_Homo sapiens_hsa006701.54188327
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.51802891
23Cell cycle_Homo sapiens_hsa041101.51524523
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39665672
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34410779
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33201750
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.28910374
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.28770091
29Homologous recombination_Homo sapiens_hsa034401.25059901
30Ribosome_Homo sapiens_hsa030101.23020612
31RNA degradation_Homo sapiens_hsa030181.17780413
32Spliceosome_Homo sapiens_hsa030401.13346282
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04493453
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01803762
35Endometrial cancer_Homo sapiens_hsa052130.99742828
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98804734
37Lysine degradation_Homo sapiens_hsa003100.97845972
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96364798
39p53 signaling pathway_Homo sapiens_hsa041150.94442019
40Base excision repair_Homo sapiens_hsa034100.94386818
41Chemical carcinogenesis_Homo sapiens_hsa052040.91833460
42Proteasome_Homo sapiens_hsa030500.91156276
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90096927
44N-Glycan biosynthesis_Homo sapiens_hsa005100.89211140
45Other glycan degradation_Homo sapiens_hsa005110.88404493
46Glycosaminoglycan degradation_Homo sapiens_hsa005310.88233124
47Pyruvate metabolism_Homo sapiens_hsa006200.87356250
48Basal cell carcinoma_Homo sapiens_hsa052170.87095161
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.85511917
50Pentose phosphate pathway_Homo sapiens_hsa000300.84370041
51Ovarian steroidogenesis_Homo sapiens_hsa049130.84138481
52Central carbon metabolism in cancer_Homo sapiens_hsa052300.83131433
53Folate biosynthesis_Homo sapiens_hsa007900.82119670
54Inositol phosphate metabolism_Homo sapiens_hsa005620.82031589
55MicroRNAs in cancer_Homo sapiens_hsa052060.80193462
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79810006
57Prion diseases_Homo sapiens_hsa050200.79567392
58Insulin signaling pathway_Homo sapiens_hsa049100.77879958
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75211289
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74990532
61Prostate cancer_Homo sapiens_hsa052150.74959501
62Pathways in cancer_Homo sapiens_hsa052000.74159655
63Shigellosis_Homo sapiens_hsa051310.73369517
64Glioma_Homo sapiens_hsa052140.72896236
65RNA polymerase_Homo sapiens_hsa030200.71881415
66Hedgehog signaling pathway_Homo sapiens_hsa043400.71081137
67Ether lipid metabolism_Homo sapiens_hsa005650.70056573
68Sulfur relay system_Homo sapiens_hsa041220.69496072
69Oocyte meiosis_Homo sapiens_hsa041140.69276049
70Acute myeloid leukemia_Homo sapiens_hsa052210.67970372
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66848501
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65667550
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65347171
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64136263
75Arginine and proline metabolism_Homo sapiens_hsa003300.63572000
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62515541
77Basal transcription factors_Homo sapiens_hsa030220.62080629
78Epstein-Barr virus infection_Homo sapiens_hsa051690.61987289
79Renal cell carcinoma_Homo sapiens_hsa052110.61804821
80Choline metabolism in cancer_Homo sapiens_hsa052310.60511189
81ErbB signaling pathway_Homo sapiens_hsa040120.59820630
82Hippo signaling pathway_Homo sapiens_hsa043900.59241434
83Vibrio cholerae infection_Homo sapiens_hsa051100.58943975
84Biosynthesis of amino acids_Homo sapiens_hsa012300.58379129
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58000019
86Herpes simplex infection_Homo sapiens_hsa051680.57632885
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57489823
88Purine metabolism_Homo sapiens_hsa002300.57343282
89Bladder cancer_Homo sapiens_hsa052190.56184212
90Arginine biosynthesis_Homo sapiens_hsa002200.55491765
91Rap1 signaling pathway_Homo sapiens_hsa040150.54649214
92Non-small cell lung cancer_Homo sapiens_hsa052230.54600375
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54578495
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.54195899
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54034060
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.53641032
97Carbon metabolism_Homo sapiens_hsa012000.53209962
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52263545
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51320432
100Tryptophan metabolism_Homo sapiens_hsa003800.50290014
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50279701
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50069785
103Hepatitis B_Homo sapiens_hsa051610.47811682
104Nucleotide excision repair_Homo sapiens_hsa034200.46625721
105Notch signaling pathway_Homo sapiens_hsa043300.45645378
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45313584
107Melanoma_Homo sapiens_hsa052180.42494532
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42392537
109Selenocompound metabolism_Homo sapiens_hsa004500.40116851
110AMPK signaling pathway_Homo sapiens_hsa041520.39501515
111Pyrimidine metabolism_Homo sapiens_hsa002400.38397998
112Apoptosis_Homo sapiens_hsa042100.38024409
113African trypanosomiasis_Homo sapiens_hsa051430.36753508
114Fatty acid elongation_Homo sapiens_hsa000620.35691037
115Wnt signaling pathway_Homo sapiens_hsa043100.35287776
116Regulation of autophagy_Homo sapiens_hsa041400.34859487
117Focal adhesion_Homo sapiens_hsa045100.34760183
118Proteoglycans in cancer_Homo sapiens_hsa052050.34369400
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31018510
120HTLV-I infection_Homo sapiens_hsa051660.30770828
121VEGF signaling pathway_Homo sapiens_hsa043700.28985397
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.28820281
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28795172
124Non-homologous end-joining_Homo sapiens_hsa034500.28649240
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28639969
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.27839606
127Tight junction_Homo sapiens_hsa045300.27530457
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.27175951
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26783414
130Complement and coagulation cascades_Homo sapiens_hsa046100.25833122
131Pancreatic cancer_Homo sapiens_hsa052120.25727931
132Viral carcinogenesis_Homo sapiens_hsa052030.24654646
133Colorectal cancer_Homo sapiens_hsa052100.24179529
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23943525
135Small cell lung cancer_Homo sapiens_hsa052220.23751143
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23121400
137Adherens junction_Homo sapiens_hsa045200.22065486

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