WDR53

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing WD domains. The function of this gene is unknown. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.13806037
2protein localization to chromosome, centromeric region (GO:0071459)5.20631502
3formation of translation preinitiation complex (GO:0001731)4.45467171
4maturation of SSU-rRNA (GO:0030490)4.41943039
5DNA deamination (GO:0045006)4.16323042
6CENP-A containing nucleosome assembly (GO:0034080)4.04818440
7proteasome assembly (GO:0043248)4.02390772
8purine nucleobase biosynthetic process (GO:0009113)4.01981607
9nucleobase biosynthetic process (GO:0046112)3.99056272
10chromatin remodeling at centromere (GO:0031055)3.87112347
11establishment of integrated proviral latency (GO:0075713)3.83940354
12transcription elongation from RNA polymerase III promoter (GO:0006385)3.83615113
13termination of RNA polymerase III transcription (GO:0006386)3.83615113
14DNA strand elongation involved in DNA replication (GO:0006271)3.77143643
15ribosomal small subunit assembly (GO:0000028)3.76319926
16viral mRNA export from host cell nucleus (GO:0046784)3.75563455
17mitotic metaphase plate congression (GO:0007080)3.74389205
18mitotic chromosome condensation (GO:0007076)3.70498235
19regulation of mitochondrial translation (GO:0070129)3.67680829
207-methylguanosine RNA capping (GO:0009452)3.62830895
21RNA capping (GO:0036260)3.62830895
22ribosomal large subunit biogenesis (GO:0042273)3.61422356
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.60926058
24DNA strand elongation (GO:0022616)3.60007655
25telomere maintenance via semi-conservative replication (GO:0032201)3.59379071
26regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.58463432
27positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.58034899
28anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.57402576
29folic acid-containing compound biosynthetic process (GO:0009396)3.55789958
30DNA replication checkpoint (GO:0000076)3.55290333
31histone exchange (GO:0043486)3.51060929
32regulation of cellular amino acid metabolic process (GO:0006521)3.50078758
33ribonucleoprotein complex biogenesis (GO:0022613)3.47733476
34protein deneddylation (GO:0000338)3.47371193
35cullin deneddylation (GO:0010388)3.46833590
36DNA replication initiation (GO:0006270)3.44797565
37establishment of chromosome localization (GO:0051303)3.44538702
38establishment of viral latency (GO:0019043)3.43890366
397-methylguanosine mRNA capping (GO:0006370)3.43764083
40ribosome assembly (GO:0042255)3.40865132
41spliceosomal snRNP assembly (GO:0000387)3.39442322
42negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.39019152
43negative regulation of ligase activity (GO:0051352)3.39019152
44DNA replication-independent nucleosome assembly (GO:0006336)3.36776897
45DNA replication-independent nucleosome organization (GO:0034724)3.36776897
46viral transcription (GO:0019083)3.35385037
47intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.34644626
48signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.34644626
49translational termination (GO:0006415)3.33863422
50signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.33625809
51signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.33625809
52signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.33625809
53IMP biosynthetic process (GO:0006188)3.33219494
54nuclear pore complex assembly (GO:0051292)3.33137955
55telomere maintenance via recombination (GO:0000722)3.32028317
56ribosome biogenesis (GO:0042254)3.31587709
57respiratory chain complex IV assembly (GO:0008535)3.30357202
58ribosomal small subunit biogenesis (GO:0042274)3.29868327
59synapsis (GO:0007129)3.26445183
60protein K6-linked ubiquitination (GO:0085020)3.26298305
61DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.25984975
62signal transduction involved in DNA integrity checkpoint (GO:0072401)3.24011940
63signal transduction involved in DNA damage checkpoint (GO:0072422)3.24011940
64mitotic sister chromatid cohesion (GO:0007064)3.23810457
65positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.21969219
66protein localization to chromosome (GO:0034502)3.21907293
67regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.20788349
68SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.20208951
69meiotic chromosome segregation (GO:0045132)3.19402681
70DNA catabolic process, exonucleolytic (GO:0000738)3.17900118
71signal transduction involved in cell cycle checkpoint (GO:0072395)3.17810455
72translational initiation (GO:0006413)3.16821638
73antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.16651489
74cotranslational protein targeting to membrane (GO:0006613)3.15691556
75mitotic recombination (GO:0006312)3.13672424
76regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.12727526
77protein targeting to ER (GO:0045047)3.11981820
78positive regulation of ligase activity (GO:0051351)3.10181774
79negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.08720558
80positive regulation of chromosome segregation (GO:0051984)3.07794832
81translational elongation (GO:0006414)3.05879838
82negative regulation of chromosome segregation (GO:0051985)3.04688334
83translation (GO:0006412)3.04461552
84rRNA processing (GO:0006364)3.03713455
85mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.03388879
86negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03081085
87negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.03081085
88negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03081085
89negative regulation of mitotic sister chromatid separation (GO:2000816)3.03081085
90negative regulation of sister chromatid segregation (GO:0033046)3.03081085
91mitotic sister chromatid segregation (GO:0000070)3.03009493
92cellular component biogenesis (GO:0044085)3.02394087
93negative regulation of DNA-dependent DNA replication (GO:2000104)3.02054319
94nuclear pore organization (GO:0006999)3.01988258
95regulation of ubiquitin-protein transferase activity (GO:0051438)3.00633401
96nucleotide-excision repair, DNA gap filling (GO:0006297)3.00592185
97regulation of DNA endoreduplication (GO:0032875)3.00255490
98attachment of spindle microtubules to kinetochore (GO:0008608)2.99184343
99telomere maintenance via telomere lengthening (GO:0010833)2.98176601
100pteridine-containing compound biosynthetic process (GO:0042559)2.97866054
101mitotic spindle checkpoint (GO:0071174)2.97805536
102sister chromatid segregation (GO:0000819)2.97684158
103protein localization to endoplasmic reticulum (GO:0070972)2.95932308
104antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.95809316
105metaphase plate congression (GO:0051310)2.95034221
106transcription-coupled nucleotide-excision repair (GO:0006283)2.94986290
107regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.94251523
108regulation of mitotic metaphase/anaphase transition (GO:0030071)2.94251523
109IMP metabolic process (GO:0046040)2.93722456
110establishment of protein localization to endoplasmic reticulum (GO:0072599)2.92880064
111histone mRNA metabolic process (GO:0008334)2.92810682
112somatic hypermutation of immunoglobulin genes (GO:0016446)2.92452745
113somatic diversification of immune receptors via somatic mutation (GO:0002566)2.92452745
114regulation of chromosome segregation (GO:0051983)2.92263935
115regulation of ligase activity (GO:0051340)2.91631600
116mitotic spindle assembly checkpoint (GO:0007094)2.90608504
117folic acid metabolic process (GO:0046655)2.89960965
118rRNA metabolic process (GO:0016072)2.89419458
119protein targeting to mitochondrion (GO:0006626)2.88865698
120RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.88850372
121tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.88850372
122spindle assembly checkpoint (GO:0071173)2.85087425
123mitotic nuclear envelope disassembly (GO:0007077)2.84535274
124kinetochore organization (GO:0051383)2.84398829
125somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.83216661
126somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.83216661
127isotype switching (GO:0045190)2.83216661
128kinetochore assembly (GO:0051382)2.83063470
129regulation of mitotic sister chromatid separation (GO:0010965)2.82001931
130regulation of mitotic sister chromatid segregation (GO:0033047)2.82001931
131regulation of sister chromatid segregation (GO:0033045)2.82001931
132G1/S transition of mitotic cell cycle (GO:0000082)2.81911883
133cell cycle G1/S phase transition (GO:0044843)2.81911883
134negative regulation of protein ubiquitination (GO:0031397)2.81309896
135spindle checkpoint (GO:0031577)2.79540152
136transcription from RNA polymerase I promoter (GO:0006360)2.77654978
137deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.77341751
138pseudouridine synthesis (GO:0001522)2.76543217
139transcription elongation from RNA polymerase II promoter (GO:0006368)2.73008452
140establishment of protein localization to mitochondrial membrane (GO:0090151)2.72602440
141rRNA modification (GO:0000154)2.72599999
142regulation of nuclear cell cycle DNA replication (GO:0033262)2.71366645
143positive regulation of viral transcription (GO:0050434)2.71304690
144regulation of double-strand break repair via homologous recombination (GO:0010569)2.70926131
145binding of sperm to zona pellucida (GO:0007339)2.70323914
146ATP synthesis coupled proton transport (GO:0015986)2.68783034
147energy coupled proton transport, down electrochemical gradient (GO:0015985)2.68783034

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.97905765
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.79483063
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.78289861
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.74167400
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.62067159
6* ETS1_20019798_ChIP-Seq_JURKAT_Human3.39927398
7* GABP_17652178_ChIP-ChIP_JURKAT_Human3.36406237
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.35634973
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.13510132
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.07922036
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.93045663
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85966471
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.85741008
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.85205669
15* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69960231
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.65476227
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.65365212
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.64329755
19* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53709380
20* VDR_23849224_ChIP-Seq_CD4+_Human2.47867142
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.46654914
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.35463946
23XRN2_22483619_ChIP-Seq_HELA_Human2.29245018
24FOXP3_21729870_ChIP-Seq_TREG_Human2.28282111
25* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27418820
26DCP1A_22483619_ChIP-Seq_HELA_Human2.27263179
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21332973
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14811848
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.10689209
30SRF_21415370_ChIP-Seq_HL-1_Mouse2.09600289
31E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00491649
32* GABP_19822575_ChIP-Seq_HepG2_Human1.98610508
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.97954595
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92512696
35AR_21909140_ChIP-Seq_LNCAP_Human1.88878873
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87044187
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.83639559
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82142322
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.80066190
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.79901702
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75214909
42* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74251885
43TTF2_22483619_ChIP-Seq_HELA_Human1.71748179
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.71422501
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68994394
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67811095
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.67248316
48* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67215991
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58465216
50ELK1_19687146_ChIP-ChIP_HELA_Human1.54381306
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52331903
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50700216
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44308442
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38039409
55KDM5A_27292631_Chip-Seq_BREAST_Human1.37994127
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36451360
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34114550
58DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.30815374
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.27728438
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.27321953
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26991861
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25472783
63CIITA_25753668_ChIP-Seq_RAJI_Human1.24687096
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23726155
65TFEB_21752829_ChIP-Seq_HELA_Human1.23660814
66* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23562142
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20658100
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19919679
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19516888
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.17435741
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16879169
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15432659
73* MYC_18940864_ChIP-ChIP_HL60_Human1.14935894
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05855775
75* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04344518
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03410951
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02531109
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00711747
79IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00353234
80KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99897594
81ELK1_22589737_ChIP-Seq_MCF10A_Human0.99258632
82* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98412524
83CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97628293
84* SPI1_23547873_ChIP-Seq_NB4_Human0.96060135
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94166843
86* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94092880
87SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91194159
88SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89828009
89* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86789469
90KAP1_22055183_ChIP-Seq_ESCs_Mouse0.83927405
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83173352
92* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83029366
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81871328
94TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77170667
95* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76992056
96TP63_19390658_ChIP-ChIP_HaCaT_Human0.75505682
97SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.74382602
98* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.73690691
99NANOG_16153702_ChIP-ChIP_HESCs_Human0.73385189
100ESR1_15608294_ChIP-ChIP_MCF-7_Human0.73290065
101ZNF274_21170338_ChIP-Seq_K562_Hela0.73222633
102SOX17_20123909_ChIP-Seq_XEN_Mouse0.72918827
103ELF5_23300383_ChIP-Seq_T47D_Human0.71361325
104ZNF263_19887448_ChIP-Seq_K562_Human0.70963355
105CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.69525861
106CTCF_18555785_ChIP-Seq_MESCs_Mouse0.69465069
107PU.1_20513432_ChIP-Seq_Bcells_Mouse0.68904838
108STAT1_20625510_ChIP-Seq_HELA_Human0.68734332
109MYB_26560356_Chip-Seq_TH2_Human0.68491159
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.68149101
111IRF8_21731497_ChIP-ChIP_J774_Mouse0.67808283
112MYB_26560356_Chip-Seq_TH1_Human0.64991122
113IRF1_19129219_ChIP-ChIP_H3396_Human0.64718457
114STAT4_19710469_ChIP-ChIP_TH1__Mouse0.64384052

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.48605091
2MP0003693_abnormal_embryo_hatching5.14215558
3MP0010094_abnormal_chromosome_stability3.86538510
4MP0004957_abnormal_blastocyst_morpholog3.83093792
5MP0003077_abnormal_cell_cycle3.44508239
6MP0003111_abnormal_nucleus_morphology3.41066598
7MP0008007_abnormal_cellular_replicative3.35408310
8MP0008877_abnormal_DNA_methylation2.95805927
9MP0008058_abnormal_DNA_repair2.57301511
10MP0003786_premature_aging2.51790711
11MP0002138_abnormal_hepatobiliary_system2.46555225
12MP0003806_abnormal_nucleotide_metabolis2.43790107
13MP0003718_maternal_effect2.28402078
14MP0009697_abnormal_copulation2.22782912
15MP0003763_abnormal_thymus_physiology2.13805195
16MP0001764_abnormal_homeostasis2.09951590
17MP0005410_abnormal_fertilization2.07557038
18MP0009333_abnormal_splenocyte_physiolog2.05240143
19MP0008932_abnormal_embryonic_tissue2.02963431
20MP0003186_abnormal_redox_activity2.02214746
21MP0000013_abnormal_adipose_tissue1.98596697
22MP0003123_paternal_imprinting1.92805667
23MP0002009_preneoplasia1.85846876
24MP0002163_abnormal_gland_morphology1.81628822
25MP0006292_abnormal_olfactory_placode1.79937012
26MP0006036_abnormal_mitochondrial_physio1.79717708
27MP0001929_abnormal_gametogenesis1.76573248
28MP0002396_abnormal_hematopoietic_system1.66945328
29MP0000490_abnormal_crypts_of1.65578148
30MP0001730_embryonic_growth_arrest1.53202886
31MP0002210_abnormal_sex_determination1.52639675
32MP0001835_abnormal_antigen_presentation1.50136699
33MP0005671_abnormal_response_to1.44654445
34MP0004147_increased_porphyrin_level1.43375664
35MP0000350_abnormal_cell_proliferation1.41641549
36MP0002796_impaired_skin_barrier1.40660772
37MP0001145_abnormal_male_reproductive1.38798528
38MP0005501_abnormal_skin_physiology1.36450688
39MP0000372_irregular_coat_pigmentation1.36274144
40MP0001188_hyperpigmentation1.35999557
41MP0000313_abnormal_cell_death1.31851171
42MP0002019_abnormal_tumor_incidence1.30218832
43MP0001661_extended_life_span1.29223731
44MP0010352_gastrointestinal_tract_polyps1.29112482
45MP0000653_abnormal_sex_gland1.28472064
46MP0009840_abnormal_foam_cell1.28458184
47MP0008260_abnormal_autophagy1.27575935
48MP0006035_abnormal_mitochondrial_morpho1.26900978
49MP0002166_altered_tumor_susceptibility1.26130514
50MP0004381_abnormal_hair_follicle1.22935355
51MP0000689_abnormal_spleen_morphology1.21227269
52MP0002132_abnormal_respiratory_system1.19602191
53MP0003656_abnormal_erythrocyte_physiolo1.19314066
54MP0000858_altered_metastatic_potential1.17725812
55MP0003950_abnormal_plasma_membrane1.13688603
56MP0000703_abnormal_thymus_morphology1.13284629
57MP0002722_abnormal_immune_system1.12282250
58MP0003698_abnormal_male_reproductive1.11589936
59MP0002398_abnormal_bone_marrow1.11492447
60MP0002006_tumorigenesis1.09029214
61MP0009780_abnormal_chondrocyte_physiolo1.08349592
62MP0001727_abnormal_embryo_implantation1.08079776
63MP0010386_abnormal_urinary_bladder1.07740866
64MP0005451_abnormal_body_composition1.05596251
65MP0002080_prenatal_lethality1.04086452
66MP0005408_hypopigmentation0.98540001
67MP0001293_anophthalmia0.97588513
68MP0000427_abnormal_hair_cycle0.96882721
69MP0000647_abnormal_sebaceous_gland0.94796445
70MP0002139_abnormal_hepatobiliary_system0.93584288
71MP0000685_abnormal_immune_system0.92367306
72MP0005266_abnormal_metabolism0.91724267
73MP0002095_abnormal_skin_pigmentation0.91482920
74MP0004233_abnormal_muscle_weight0.90535700
75MP0002429_abnormal_blood_cell0.90534196
76MP0003011_delayed_dark_adaptation0.89548790
77MP0001697_abnormal_embryo_size0.89285330
78MP0005310_abnormal_salivary_gland0.89260118
79MP0005380_embryogenesis_phenotype0.88557082
80MP0001672_abnormal_embryogenesis/_devel0.88557082
81MP0001119_abnormal_female_reproductive0.88401587
82MP0000358_abnormal_cell_content/0.85631354
83MP0001873_stomach_inflammation0.85241069
84MP0005379_endocrine/exocrine_gland_phen0.85235498
85MP0001216_abnormal_epidermal_layer0.85205491
86MP0003866_abnormal_defecation0.84926385
87MP0003646_muscle_fatigue0.83985131
88MP0000716_abnormal_immune_system0.83561442
89MP0004197_abnormal_fetal_growth/weight/0.81890605
90MP0000015_abnormal_ear_pigmentation0.81195969
91MP0005647_abnormal_sex_gland0.81157183
92MP0002084_abnormal_developmental_patter0.81035047
93MP0010307_abnormal_tumor_latency0.80957427
94MP0005085_abnormal_gallbladder_physiolo0.78653558
95MP0002086_abnormal_extraembryonic_tissu0.78387659
96MP0001191_abnormal_skin_condition0.77112252
97MP0001243_abnormal_dermal_layer0.76261938
98MP0005319_abnormal_enzyme/_coenzyme0.76201353
99MP0003941_abnormal_skin_development0.75049511
100MP0005075_abnormal_melanosome_morpholog0.74670647
101MP0005395_other_phenotype0.74354128
102MP0001853_heart_inflammation0.74141110
103MP0005384_cellular_phenotype0.73944667
104MP0002161_abnormal_fertility/fecundity0.73763419
105MP0003984_embryonic_growth_retardation0.73683255
106MP0003699_abnormal_female_reproductive0.72850190
107MP0005084_abnormal_gallbladder_morpholo0.72833116
108MP0008789_abnormal_olfactory_epithelium0.72537551
109MP0005000_abnormal_immune_tolerance0.71372247
110MP0002088_abnormal_embryonic_growth/wei0.70513192
111MP0003890_abnormal_embryonic-extraembry0.70409235
112MP0005376_homeostasis/metabolism_phenot0.70149758
113MP0004808_abnormal_hematopoietic_stem0.69004805
114MP0001800_abnormal_humoral_immune0.68881836
115MP0009672_abnormal_birth_weight0.68129751
116MP0001986_abnormal_taste_sensitivity0.67758438
117MP0002420_abnormal_adaptive_immunity0.67722849
118MP0001545_abnormal_hematopoietic_system0.67632169
119MP0005397_hematopoietic_system_phenotyp0.67632169
120MP0003436_decreased_susceptibility_to0.67487085
121MP0002148_abnormal_hypersensitivity_rea0.67134280
122MP0009379_abnormal_foot_pigmentation0.67062625
123MP0002876_abnormal_thyroid_physiology0.67055819
124MP0001819_abnormal_immune_cell0.66070292
125MP0003221_abnormal_cardiomyocyte_apopto0.64776554
126MP0005365_abnormal_bile_salt0.62936322
127MP0008995_early_reproductive_senescence0.62070969
128MP0002277_abnormal_respiratory_mucosa0.62011712
129MP0002723_abnormal_immune_serum0.61921208
130MP0000613_abnormal_salivary_gland0.61867335
131MP0000598_abnormal_liver_morphology0.61780867
132MP0002405_respiratory_system_inflammati0.61648880
133MP0002877_abnormal_melanocyte_morpholog0.60342286
134MP0002090_abnormal_vision0.60329329
135MP0000609_abnormal_liver_physiology0.59959954
136MP0002085_abnormal_embryonic_tissue0.59526492
137MP0000003_abnormal_adipose_tissue0.59056847

Predicted human phenotypes

RankGene SetZ-score
111 pairs of ribs (HP:0000878)4.78421694
2Hepatocellular necrosis (HP:0001404)4.19276738
3Reticulocytopenia (HP:0001896)3.92676668
4Hepatic necrosis (HP:0002605)3.89702019
5Meckel diverticulum (HP:0002245)3.86181965
6Panhypogammaglobulinemia (HP:0003139)3.81347481
7Abnormality of the ileum (HP:0001549)3.64287147
8Acute necrotizing encephalopathy (HP:0006965)3.64217623
9Birth length less than 3rd percentile (HP:0003561)3.63798789
10Abnormality of cells of the erythroid lineage (HP:0012130)3.60868430
11Mitochondrial inheritance (HP:0001427)3.47824242
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.46046446
13Abnormal mitochondria in muscle tissue (HP:0008316)3.35277012
14Abnormal number of erythroid precursors (HP:0012131)3.31762142
15Acute encephalopathy (HP:0006846)3.20727737
16Increased CSF lactate (HP:0002490)3.19868272
17Microretrognathia (HP:0000308)3.04791191
18Selective tooth agenesis (HP:0001592)3.03868054
19Duodenal stenosis (HP:0100867)3.01357560
20Small intestinal stenosis (HP:0012848)3.01357560
21Agammaglobulinemia (HP:0004432)2.97639385
22Pancytopenia (HP:0001876)2.97107411
23Macrocytic anemia (HP:0001972)2.91722217
24Volvulus (HP:0002580)2.89001995
25Myelodysplasia (HP:0002863)2.82995162
26Chromsome breakage (HP:0040012)2.79989405
27Progressive macrocephaly (HP:0004481)2.78586315
28Rough bone trabeculation (HP:0100670)2.76417527
29Oral leukoplakia (HP:0002745)2.72611522
30Abnormality of glycolysis (HP:0004366)2.72286784
31Increased serum pyruvate (HP:0003542)2.72286784
32Secondary amenorrhea (HP:0000869)2.71921695
33Breast hypoplasia (HP:0003187)2.71665745
34Lipid accumulation in hepatocytes (HP:0006561)2.70744554
35Increased serum lactate (HP:0002151)2.66236644
36CNS demyelination (HP:0007305)2.66190184
37Increased hepatocellular lipid droplets (HP:0006565)2.63436727
38Cholecystitis (HP:0001082)2.63256049
39Abnormal gallbladder physiology (HP:0012438)2.63256049
40Microvesicular hepatic steatosis (HP:0001414)2.61972622
41Type I transferrin isoform profile (HP:0003642)2.55785469
42Entropion (HP:0000621)2.54214961
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.53876386
44Cerebral edema (HP:0002181)2.53750373
45Decreased activity of mitochondrial respiratory chain (HP:0008972)2.53435833
46Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.53435833
47Combined immunodeficiency (HP:0005387)2.51683568
48Abnormality of the anterior horn cell (HP:0006802)2.51560157
49Degeneration of anterior horn cells (HP:0002398)2.51560157
50B lymphocytopenia (HP:0010976)2.50345350
51Abnormality of the duodenum (HP:0002246)2.49810590
52Clubbing of toes (HP:0100760)2.49328018
53Impulsivity (HP:0100710)2.46783991
54Pallor (HP:0000980)2.46029042
55Ureteral duplication (HP:0000073)2.44410720
56Abnormality of the heme biosynthetic pathway (HP:0010472)2.40841285
57Cerebral hypomyelination (HP:0006808)2.39622814
58Severe combined immunodeficiency (HP:0004430)2.39147047
59Abnormal delayed hypersensitivity skin test (HP:0002963)2.39120811
60Missing ribs (HP:0000921)2.39024031
61Ependymoma (HP:0002888)2.37784520
62Abnormality of DNA repair (HP:0003254)2.34770429
63Recurrent bacterial skin infections (HP:0005406)2.33784904
64Lactic acidosis (HP:0003128)2.32200076
65Sparse eyelashes (HP:0000653)2.32031213
66Premature ovarian failure (HP:0008209)2.30947223
67Abnormal lung lobation (HP:0002101)2.29189153
68Emotional lability (HP:0000712)2.28009553
69Abnormality of the labia minora (HP:0012880)2.27105797
70Aplastic anemia (HP:0001915)2.26921944
71Abnormality of pyrimidine metabolism (HP:0004353)2.26899638
72Abnormality of aromatic amino acid family metabolism (HP:0004338)2.25833550
73Testicular atrophy (HP:0000029)2.25332026
74Abnormal spermatogenesis (HP:0008669)2.25278082
75Gout (HP:0001997)2.24027688
76Abnormality of B cell number (HP:0010975)2.24010010
77Hyperglycinuria (HP:0003108)2.23330590
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20862596
79Cellular immunodeficiency (HP:0005374)2.19866196
80Multiple enchondromatosis (HP:0005701)2.18955626
81Dry hair (HP:0011359)2.18910283
823-Methylglutaconic aciduria (HP:0003535)2.18150212
83Colon cancer (HP:0003003)2.17995183
84Exertional dyspnea (HP:0002875)2.15256773
85Abnormal trabecular bone morphology (HP:0100671)2.15025043
86Rhabdomyosarcoma (HP:0002859)2.14755612
87Abnormality of the carotid arteries (HP:0005344)2.14603383
88Horseshoe kidney (HP:0000085)2.12250350
89Poikiloderma (HP:0001029)2.12082384
90Infertility (HP:0000789)2.11545125
91Poor head control (HP:0002421)2.10574577
92Abnormality of T cell physiology (HP:0011840)2.09870291
93Gonadotropin excess (HP:0000837)2.08161516
94Bone marrow hypocellularity (HP:0005528)2.06265859
95Villous atrophy (HP:0011473)2.05438736
96Abnormality of small intestinal villus morphology (HP:0011472)2.05438736
97Respiratory failure (HP:0002878)2.05290536
98Lethargy (HP:0001254)2.05172658
99Hypoplasia of the capital femoral epiphysis (HP:0003090)2.01736899
100Neutropenia (HP:0001875)1.99784357
101Agnosia (HP:0010524)1.99154507
102Encephalitis (HP:0002383)1.99142499
103Chronic bronchitis (HP:0004469)1.98873760
104Prominent metopic ridge (HP:0005487)1.98539959
105Abnormal respiratory epithelium morphology (HP:0012253)1.97421604
106Abnormal respiratory motile cilium morphology (HP:0005938)1.97421604
107Megaloblastic anemia (HP:0001889)1.95309793
108Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.94597586
109Exercise intolerance (HP:0003546)1.92921646
110Gastrointestinal infarctions (HP:0005244)1.92474063
111Respiratory difficulties (HP:0002880)1.91760756
112Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91668896
113Abnormality of lateral ventricle (HP:0030047)1.91460933
114Dynein arm defect of respiratory motile cilia (HP:0012255)1.88396966
115Absent/shortened dynein arms (HP:0200106)1.88396966
116Abnormal protein glycosylation (HP:0012346)1.88373814
117Abnormal glycosylation (HP:0012345)1.88373814
118Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88373814
119Abnormal protein N-linked glycosylation (HP:0012347)1.88373814
120Duplicated collecting system (HP:0000081)1.88290776
121Abnormality of the preputium (HP:0100587)1.88082867
122Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.86103314
123Atrophy/Degeneration involving motor neurons (HP:0007373)1.86013298
124Nephroblastoma (Wilms tumor) (HP:0002667)1.84809602
125Hypoplasia of the radius (HP:0002984)1.84708110
126Oligodactyly (hands) (HP:0001180)1.83352457
127Abnormality of chromosome stability (HP:0003220)1.82801609
128Recurrent abscess formation (HP:0002722)1.82113906
129Absent thumb (HP:0009777)1.81835798
130Glioma (HP:0009733)1.80735148
131Facial cleft (HP:0002006)1.80409665
132Sloping forehead (HP:0000340)1.79097724
133Congenital ichthyosiform erythroderma (HP:0007431)1.78676302
134Reduced antithrombin III activity (HP:0001976)1.78324541
135Carpal bone hypoplasia (HP:0001498)1.77575607
136CNS hypomyelination (HP:0003429)1.77399980
137Hypoproteinemia (HP:0003075)1.77127976
138Cleft eyelid (HP:0000625)1.76919381
139Recurrent viral infections (HP:0004429)1.76465243
140Increased intramyocellular lipid droplets (HP:0012240)1.75876730
141Increased muscle lipid content (HP:0009058)1.75791229
142Astrocytoma (HP:0009592)1.75264768
143Abnormality of the astrocytes (HP:0100707)1.75264768
144Abnormality of serine family amino acid metabolism (HP:0010894)1.75245934
145Abnormality of glycine metabolism (HP:0010895)1.75245934
146Hypokinesia (HP:0002375)1.73811802
147Progressive muscle weakness (HP:0003323)1.73629168
148Ectopic kidney (HP:0000086)1.73221958
149Recurrent cutaneous fungal infections (HP:0011370)1.71106387
150Chronic mucocutaneous candidiasis (HP:0002728)1.71106387
151Squamous cell carcinoma (HP:0002860)1.70512537
152Cafe-au-lait spot (HP:0000957)1.70041380
153Sensory axonal neuropathy (HP:0003390)1.68746698
154Autoimmune hemolytic anemia (HP:0001890)1.68065863

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.13143548
2EIF2AK14.67531493
3WEE13.44469780
4PBK3.19510149
5STK162.98278260
6CDC72.93352278
7BMPR1B2.76839167
8VRK22.66012473
9DYRK32.60841150
10TRIM282.44411982
11EIF2AK32.31180348
12PDK32.31067668
13PDK42.31067668
14NME22.26179499
15RIPK12.22534075
16PLK42.14041498
17TSSK62.11221118
18NUAK12.05121881
19TLK12.00907529
20VRK11.83213518
21NEK21.79972064
22TTK1.79560427
23BRSK21.76601473
24PLK11.65823357
25ACVR1B1.65162149
26ATR1.59170645
27STK101.56069752
28PASK1.54645527
29NEK11.54290915
30TESK11.42228592
31TGFBR11.39638860
32ARAF1.39420778
33BRAF1.37603528
34PDK21.36874092
35MAP4K21.35607507
36MST41.33071454
37RPS6KA41.32464003
38SRPK11.31411711
39PIM21.31298715
40AURKB1.29162778
41IRAK21.23484887
42BRSK11.22631935
43PLK31.21484763
44AURKA1.20929180
45PNCK1.20101421
46BCKDK1.12813742
47MET1.12804973
48CDK41.11408521
49CDK71.10959256
50EIF2AK21.10842253
51SCYL21.10797732
52MKNK11.07332438
53ZAK1.06837728
54CDK91.04868562
55TESK20.98845429
56MAP4K10.96164528
57MUSK0.92650490
58KIT0.92394005
59FLT30.91273717
60SIK30.90466847
61NME10.89782342
62CDK80.88995620
63CHEK10.87380035
64BCR0.87290803
65PIM10.85747438
66CHEK20.84375626
67WNK30.83894941
68MAP3K80.82108205
69MKNK20.81269704
70EPHA20.81187853
71TEC0.78058992
72MST1R0.76951694
73CSNK2A20.76279285
74ERBB30.75922781
75CSNK2A10.73201004
76RPS6KB20.73000117
77CCNB10.72903540
78KDR0.72571748
79CLK10.72508252
80STK40.72140225
81PRKCI0.71518286
82STK38L0.70182931
83ZAP700.69905889
84IRAK30.65505289
85ILK0.64382030
86LRRK20.60804902
87JAK30.59798982
88IKBKB0.59105951
89PAK10.57432770
90MOS0.57430697
91ATM0.54520157
92STK30.53604819
93CDK190.51744290
94BMPR20.51350642
95SMG10.50056214
96DAPK10.49800579
97CSNK1G10.49686583
98CDK20.48177175
99TXK0.48110511
100TAOK30.46338451
101PLK20.46132652
102ABL20.44941103
103MAP3K120.44871017
104GRK70.44059503
105MARK30.43869940
106PAK40.43867841
107TYK20.41001306
108SYK0.40973685
109DYRK20.40857377
110TAF10.40407778
111MAPK110.39881112
112RAF10.39750127
113MAPKAPK30.38916019
114CSNK1E0.37847131
115MAP3K90.36646247
116GRK10.36293860
117ALK0.36290127
118CSF1R0.35951848
119CDK10.35317291
120PIK3CG0.35158930
121CSNK1G30.35116888
122MAP2K70.34773561
123MELK0.34743526
124TNIK0.34576552
125CHUK0.34561363
126RPS6KA50.34071384
127STK240.32315986
128MAP3K50.30314850
129IRAK40.30144150
130MAP3K60.29728228
131LCK0.29067760
132LYN0.27510129
133MAP3K110.26797974
134MAPKAPK20.26716600
135MYLK0.26417255

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.13337539
2RNA polymerase_Homo sapiens_hsa030204.11509446
3DNA replication_Homo sapiens_hsa030303.78578793
4Ribosome_Homo sapiens_hsa030103.49399986
5Mismatch repair_Homo sapiens_hsa034303.06050833
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.94256097
7RNA transport_Homo sapiens_hsa030132.68718001
8Non-homologous end-joining_Homo sapiens_hsa034502.66094855
9Pyrimidine metabolism_Homo sapiens_hsa002402.56057043
10Base excision repair_Homo sapiens_hsa034102.55836241
11Spliceosome_Homo sapiens_hsa030402.44127596
12Protein export_Homo sapiens_hsa030602.41942363
13Vitamin B6 metabolism_Homo sapiens_hsa007502.36685509
14Homologous recombination_Homo sapiens_hsa034402.35111516
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.16709521
16Nucleotide excision repair_Homo sapiens_hsa034202.16011434
17Cell cycle_Homo sapiens_hsa041102.14346334
18Basal transcription factors_Homo sapiens_hsa030222.11192153
19Oxidative phosphorylation_Homo sapiens_hsa001901.93224131
20One carbon pool by folate_Homo sapiens_hsa006701.83915854
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74185171
22Fanconi anemia pathway_Homo sapiens_hsa034601.72575166
23Folate biosynthesis_Homo sapiens_hsa007901.68990495
24Parkinsons disease_Homo sapiens_hsa050121.55509527
25Huntingtons disease_Homo sapiens_hsa050161.53697395
26RNA degradation_Homo sapiens_hsa030181.51646870
27Purine metabolism_Homo sapiens_hsa002301.46847200
28Selenocompound metabolism_Homo sapiens_hsa004501.44579252
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42734424
30p53 signaling pathway_Homo sapiens_hsa041151.38577875
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.36718527
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.30507101
33Pentose phosphate pathway_Homo sapiens_hsa000301.23709527
34Steroid biosynthesis_Homo sapiens_hsa001001.23385531
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20823534
36Epstein-Barr virus infection_Homo sapiens_hsa051691.16285181
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09048694
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.08786428
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04813564
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03493118
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94928359
42Alzheimers disease_Homo sapiens_hsa050100.89582350
43Biosynthesis of amino acids_Homo sapiens_hsa012300.88590317
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86279515
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76728805
46mRNA surveillance pathway_Homo sapiens_hsa030150.76696938
47Sulfur relay system_Homo sapiens_hsa041220.75597996
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.74727252
49Glutathione metabolism_Homo sapiens_hsa004800.73714537
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73637091
51Pyruvate metabolism_Homo sapiens_hsa006200.72370189
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72223308
53Other glycan degradation_Homo sapiens_hsa005110.69698698
54Metabolic pathways_Homo sapiens_hsa011000.68068120
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64879544
56Fructose and mannose metabolism_Homo sapiens_hsa000510.63160077
57Linoleic acid metabolism_Homo sapiens_hsa005910.62689412
58Carbon metabolism_Homo sapiens_hsa012000.61770695
59Regulation of autophagy_Homo sapiens_hsa041400.59558429
60Antigen processing and presentation_Homo sapiens_hsa046120.57033834
61Autoimmune thyroid disease_Homo sapiens_hsa053200.56600387
62Systemic lupus erythematosus_Homo sapiens_hsa053220.56452574
63N-Glycan biosynthesis_Homo sapiens_hsa005100.55514998
64Primary immunodeficiency_Homo sapiens_hsa053400.53637120
65Retinol metabolism_Homo sapiens_hsa008300.49878668
66Viral carcinogenesis_Homo sapiens_hsa052030.49542223
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48699895
68Herpes simplex infection_Homo sapiens_hsa051680.47210584
69Propanoate metabolism_Homo sapiens_hsa006400.45952977
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44874951
71Arachidonic acid metabolism_Homo sapiens_hsa005900.44017248
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43709719
73Collecting duct acid secretion_Homo sapiens_hsa049660.43544926
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43459800
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43430692
76Peroxisome_Homo sapiens_hsa041460.42399472
77Sulfur metabolism_Homo sapiens_hsa009200.41921322
78Type I diabetes mellitus_Homo sapiens_hsa049400.41400727
79Fatty acid metabolism_Homo sapiens_hsa012120.41311028
80Oocyte meiosis_Homo sapiens_hsa041140.41201942
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40343739
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37929955
83Shigellosis_Homo sapiens_hsa051310.37499387
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36505971
85HTLV-I infection_Homo sapiens_hsa051660.36104365
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35991527
87Vibrio cholerae infection_Homo sapiens_hsa051100.35389760
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.34991301
89beta-Alanine metabolism_Homo sapiens_hsa004100.34105039
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33312225
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33280594
92Galactose metabolism_Homo sapiens_hsa000520.32239813
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31432480
94Chemical carcinogenesis_Homo sapiens_hsa052040.30563784
95Graft-versus-host disease_Homo sapiens_hsa053320.30488464
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.28800000
97Measles_Homo sapiens_hsa051620.28603637
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28026105
99Asthma_Homo sapiens_hsa053100.26229485
100Allograft rejection_Homo sapiens_hsa053300.26173921
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25104107
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24248484
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.23442999
104Phenylalanine metabolism_Homo sapiens_hsa003600.23047066
105Legionellosis_Homo sapiens_hsa051340.22322982
106Arginine and proline metabolism_Homo sapiens_hsa003300.20875236
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20821682
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.20569001
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20555337
110Ether lipid metabolism_Homo sapiens_hsa005650.20185087
111Histidine metabolism_Homo sapiens_hsa003400.20031698
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20021764
113Tyrosine metabolism_Homo sapiens_hsa003500.18424677
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.18349202
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.17926657
116Lysine degradation_Homo sapiens_hsa003100.17168394
117Apoptosis_Homo sapiens_hsa042100.17153908
118Sphingolipid metabolism_Homo sapiens_hsa006000.16958928
119Fatty acid degradation_Homo sapiens_hsa000710.16779260
120Rheumatoid arthritis_Homo sapiens_hsa053230.16511273
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15992074
122Thyroid cancer_Homo sapiens_hsa052160.15282097
123Cardiac muscle contraction_Homo sapiens_hsa042600.15083366
124Viral myocarditis_Homo sapiens_hsa054160.14600460
125Butanoate metabolism_Homo sapiens_hsa006500.13758990
126Fatty acid elongation_Homo sapiens_hsa000620.13128947

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