WDR54

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of smell (GO:0007608)5.91875347
2axon ensheathment in central nervous system (GO:0032291)5.91247830
3central nervous system myelination (GO:0022010)5.91247830
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.22513440
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.01942272
6ATP synthesis coupled proton transport (GO:0015986)5.01942272
7neuron cell-cell adhesion (GO:0007158)4.85715670
8viral transcription (GO:0019083)4.82477995
9ribosomal small subunit assembly (GO:0000028)4.74548529
10translational termination (GO:0006415)4.67438818
11protein localization to cilium (GO:0061512)4.51917025
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.46912826
13presynaptic membrane assembly (GO:0097105)4.30893453
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.22427494
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.21946321
16cotranslational protein targeting to membrane (GO:0006613)4.20188028
17presynaptic membrane organization (GO:0097090)4.17020420
18protein targeting to ER (GO:0045047)4.10546792
19protein complex biogenesis (GO:0070271)4.09440108
20sequestering of actin monomers (GO:0042989)4.08562295
21cilium or flagellum-dependent cell motility (GO:0001539)4.08508744
22translational elongation (GO:0006414)3.98743252
23mitochondrial respiratory chain complex I assembly (GO:0032981)3.95462238
24NADH dehydrogenase complex assembly (GO:0010257)3.95462238
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.95462238
26motile cilium assembly (GO:0044458)3.93398350
27pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.93002290
28establishment of protein localization to endoplasmic reticulum (GO:0072599)3.92782839
29protein localization to endoplasmic reticulum (GO:0070972)3.89079023
30respiratory electron transport chain (GO:0022904)3.81112062
31electron transport chain (GO:0022900)3.79444469
32mitochondrial respiratory chain complex assembly (GO:0033108)3.79023997
33cilium movement (GO:0003341)3.75454985
34base-excision repair, AP site formation (GO:0006285)3.71949538
35cellular protein complex disassembly (GO:0043624)3.70319199
36neuronal action potential propagation (GO:0019227)3.69576686
37sensory perception of chemical stimulus (GO:0007606)3.68488282
38chaperone-mediated protein transport (GO:0072321)3.66736969
39maturation of SSU-rRNA (GO:0030490)3.65094959
40neuron recognition (GO:0008038)3.64072659
41viral life cycle (GO:0019058)3.64031137
42vocalization behavior (GO:0071625)3.63945723
43positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.61008091
44synaptic vesicle exocytosis (GO:0016079)3.60286447
45axonemal dynein complex assembly (GO:0070286)3.59730642
46negative regulation of neurotransmitter transport (GO:0051589)3.59061471
47regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.58892191
48glutamate secretion (GO:0014047)3.57129154
49nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.56908855
50myelination (GO:0042552)3.54788841
51protein localization to synapse (GO:0035418)3.53857734
52axon ensheathment (GO:0008366)3.51539996
53ensheathment of neurons (GO:0007272)3.51539996
54negative regulation of neurotransmitter secretion (GO:0046929)3.50157081
55transmission of nerve impulse (GO:0019226)3.49185064
56axonal fasciculation (GO:0007413)3.47194190
57long-chain fatty acid biosynthetic process (GO:0042759)3.44876689
58pyrimidine nucleotide catabolic process (GO:0006244)3.44342323
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.42790422
60RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.42790422
61negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.40898853
62left/right pattern formation (GO:0060972)3.40261932
63epithelial cilium movement (GO:0003351)3.35738389
64positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.34697565
65adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.33967052
66cilium organization (GO:0044782)3.32620366
67protein polyglutamylation (GO:0018095)3.29992939
68behavioral response to cocaine (GO:0048148)3.29851128
69protein complex disassembly (GO:0043241)3.29531038
70translational initiation (GO:0006413)3.28647454
71cilium assembly (GO:0042384)3.27215448
72pyrimidine nucleobase catabolic process (GO:0006208)3.26327366
73neuronal ion channel clustering (GO:0045161)3.25573332
74regulation of cilium movement (GO:0003352)3.22693155
75axoneme assembly (GO:0035082)3.21491134
76DNA damage response, detection of DNA damage (GO:0042769)3.21316100
77macromolecular complex disassembly (GO:0032984)3.19617230
78regulation of short-term neuronal synaptic plasticity (GO:0048172)3.18680360
79fatty acid elongation (GO:0030497)3.13980586
80behavioral response to nicotine (GO:0035095)3.13321843
81regulation of synaptic vesicle exocytosis (GO:2000300)3.11239125
82membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.07432905
83regulation of mitochondrial translation (GO:0070129)3.07246144
84mating behavior (GO:0007617)3.06936221
85ATP biosynthetic process (GO:0006754)3.05794632
86regulation of glutamate receptor signaling pathway (GO:1900449)3.05792097
87adult walking behavior (GO:0007628)3.05358795
88epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.04481876
89purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.04268219
90purine nucleoside triphosphate biosynthetic process (GO:0009145)3.03521338
91synaptic vesicle maturation (GO:0016188)3.03171818
92positive regulation of mitochondrial fission (GO:0090141)3.02187426
93negative regulation of synaptic transmission, GABAergic (GO:0032229)3.02098547
94postsynaptic membrane organization (GO:0001941)3.01780184
95neuron-neuron synaptic transmission (GO:0007270)3.01742984
96nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01371166
97detection of calcium ion (GO:0005513)3.01265818
98apical protein localization (GO:0045176)3.01064525
99gamma-aminobutyric acid signaling pathway (GO:0007214)3.00331613
100GTP biosynthetic process (GO:0006183)2.99434576
101aldehyde catabolic process (GO:0046185)2.98646971
102ribosomal small subunit biogenesis (GO:0042274)2.98575635
103dendritic spine morphogenesis (GO:0060997)2.98507675
104pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.98083244
105ionotropic glutamate receptor signaling pathway (GO:0035235)2.98060234
106protein neddylation (GO:0045116)2.97269484
107cerebellar granule cell differentiation (GO:0021707)2.93873931
108female mating behavior (GO:0060180)2.92895120
109glutamate receptor signaling pathway (GO:0007215)2.92508159
110establishment of integrated proviral latency (GO:0075713)2.91072037
111synaptic transmission, glutamatergic (GO:0035249)2.90373492
112eye photoreceptor cell differentiation (GO:0001754)2.90011096
113photoreceptor cell differentiation (GO:0046530)2.90011096
114synaptic vesicle docking involved in exocytosis (GO:0016081)2.89295809
115inner mitochondrial membrane organization (GO:0007007)2.88210292
116regulation of protein kinase A signaling (GO:0010738)2.87545376
117regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.87352770
118cullin deneddylation (GO:0010388)2.86940846
119centriole replication (GO:0007099)2.86850817
120microtubule depolymerization (GO:0007019)2.85992595
121cell migration in hindbrain (GO:0021535)2.85262842
122synaptic transmission, dopaminergic (GO:0001963)2.84139616
123translation (GO:0006412)2.82948417
124exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82277930
125oligodendrocyte differentiation (GO:0048709)2.82011389
126respiratory chain complex IV assembly (GO:0008535)2.80668863
127ribosomal large subunit biogenesis (GO:0042273)2.79358144
128establishment of mitochondrion localization (GO:0051654)2.78070451
129cerebral cortex radially oriented cell migration (GO:0021799)2.76659362
130short-term memory (GO:0007614)2.74625504
131positive regulation of membrane potential (GO:0045838)2.74565881
132ribonucleoside triphosphate biosynthetic process (GO:0009201)2.74406359
133regulation of female receptivity (GO:0045924)2.73683057
134nuclear-transcribed mRNA catabolic process (GO:0000956)2.72893757
135protein targeting to membrane (GO:0006612)2.72552913
136chromatin remodeling at centromere (GO:0031055)2.72480273
137protein deneddylation (GO:0000338)2.71116358
138nucleoside triphosphate biosynthetic process (GO:0009142)2.70701734
139regulation of voltage-gated calcium channel activity (GO:1901385)2.70309068
140regulation of neuronal synaptic plasticity (GO:0048168)2.70118406
141regulation of excitatory postsynaptic membrane potential (GO:0060079)2.69796297
142G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.69774490
143cytochrome complex assembly (GO:0017004)2.69531149
144positive regulation of synapse assembly (GO:0051965)2.68523938
145regulation of long-term neuronal synaptic plasticity (GO:0048169)2.65273313
146synapse assembly (GO:0007416)2.65225957
147establishment of viral latency (GO:0019043)2.64994482
148intraciliary transport (GO:0042073)2.64817119
149dendrite development (GO:0016358)2.64491493
150hydrogen ion transmembrane transport (GO:1902600)2.63638493
151positive regulation of action potential (GO:0045760)2.63242172
152microtubule severing (GO:0051013)2.63069390
153nonmotile primary cilium assembly (GO:0035058)2.62564571
154cilium morphogenesis (GO:0060271)2.62553852
155regulation of glutamate secretion (GO:0014048)2.62183090
156regulation of synaptic vesicle transport (GO:1902803)2.61481238
157regulation of catecholamine metabolic process (GO:0042069)2.60813813
158regulation of dopamine metabolic process (GO:0042053)2.60813813
159substantia nigra development (GO:0021762)2.60401712
160neuronal action potential (GO:0019228)2.59920392
161ubiquinone biosynthetic process (GO:0006744)2.59732264
162CENP-A containing nucleosome assembly (GO:0034080)2.59583690
163oxidative phosphorylation (GO:0006119)2.59445977
164organelle disassembly (GO:1903008)2.59397424
165nucleoside diphosphate phosphorylation (GO:0006165)2.59067975
166deoxyribonucleotide catabolic process (GO:0009264)2.58609207
167regulation of dendritic spine morphogenesis (GO:0061001)2.57935639
168UTP biosynthetic process (GO:0006228)2.57565856
169ventricular system development (GO:0021591)2.57243316
170asymmetric protein localization (GO:0008105)2.57065782
171mRNA catabolic process (GO:0006402)2.57044503
172cyclic nucleotide catabolic process (GO:0009214)2.56842952
173proteasome assembly (GO:0043248)2.56625725
174regulation of microtubule-based movement (GO:0060632)2.56223035
175intracellular protein transmembrane import (GO:0044743)2.55595738
176platelet dense granule organization (GO:0060155)2.55031510
177limb bud formation (GO:0060174)2.54999402
178regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.54698832
179long-term synaptic potentiation (GO:0060291)2.53793597
180membrane hyperpolarization (GO:0060081)2.53426164
181negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.53339831
182DNA ligation (GO:0006266)2.53164346
183regulation of postsynaptic membrane potential (GO:0060078)2.53019120
184regulation of neurotransmitter secretion (GO:0046928)2.52865817
185protein-cofactor linkage (GO:0018065)2.51800990
186calcium ion-dependent exocytosis (GO:0017156)2.51670353
187ubiquinone metabolic process (GO:0006743)2.51540878
188negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.50614502
189resolution of meiotic recombination intermediates (GO:0000712)2.50372475

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.16260492
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.91015122
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.81966476
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.62951126
5GBX2_23144817_ChIP-Seq_PC3_Human3.62055561
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.31050673
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.99140297
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87408217
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.81422639
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.81386684
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.75233216
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.72837416
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.66078619
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63645845
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.62154967
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60644959
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60644959
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.51818133
19ZNF274_21170338_ChIP-Seq_K562_Hela2.47974341
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.46165226
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.45334182
22TAF15_26573619_Chip-Seq_HEK293_Human2.43631187
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.42858502
24JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40768389
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.39686952
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37549399
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33663239
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32612537
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28099759
30* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.27589486
31* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26114644
32EZH2_27294783_Chip-Seq_ESCs_Mouse2.22621622
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20574370
34* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19163479
35BMI1_23680149_ChIP-Seq_NPCS_Mouse2.11710075
36* VDR_23849224_ChIP-Seq_CD4+_Human2.06249324
37ELK1_19687146_ChIP-ChIP_HELA_Human2.05763184
38RNF2_27304074_Chip-Seq_ESCs_Mouse2.05603483
39REST_21632747_ChIP-Seq_MESCs_Mouse2.02760771
40E2F4_17652178_ChIP-ChIP_JURKAT_Human2.01261655
41XRN2_22483619_ChIP-Seq_HELA_Human1.99988232
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.97151293
43MYC_18940864_ChIP-ChIP_HL60_Human1.94780701
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.91596007
45DROSHA_22980978_ChIP-Seq_HELA_Human1.90384805
46TTF2_22483619_ChIP-Seq_HELA_Human1.88903696
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.86027855
48IRF1_19129219_ChIP-ChIP_H3396_Human1.85803608
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82350918
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.81354867
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.79365256
52RNF2_27304074_Chip-Seq_NSC_Mouse1.78839052
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78720721
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.76948340
55RARB_27405468_Chip-Seq_BRAIN_Mouse1.76798396
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75253631
57FOXP3_21729870_ChIP-Seq_TREG_Human1.74962526
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.72942415
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70224425
60GABP_19822575_ChIP-Seq_HepG2_Human1.66165882
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65749451
62VDR_22108803_ChIP-Seq_LS180_Human1.64989792
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62932597
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.62609406
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60794002
66EWS_26573619_Chip-Seq_HEK293_Human1.59840189
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55853576
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54553745
69MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53796374
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53613376
71E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53377897
72FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52796067
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49086113
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.48042737
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44709082
76P300_19829295_ChIP-Seq_ESCs_Human1.42950778
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42331940
78MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42291880
79SOX2_16153702_ChIP-ChIP_HESCs_Human1.40230938
80DCP1A_22483619_ChIP-Seq_HELA_Human1.40194678
81SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.38548528
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37995498
83ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37607810
84SMAD4_21799915_ChIP-Seq_A2780_Human1.35666467
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34843252
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33290135
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.33215761
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31908845
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31141518
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30606435
91CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30018078
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29624307
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.28596988
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27552762
95EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.26256838
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25949270
97SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25817021
98PIAS1_25552417_ChIP-Seq_VCAP_Human1.24864466
99AR_21572438_ChIP-Seq_LNCaP_Human1.24116786
100RING1B_27294783_Chip-Seq_NPCs_Mouse1.23845939
101GATA1_26923725_Chip-Seq_HPCs_Mouse1.22275999
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21672593
103TP63_19390658_ChIP-ChIP_HaCaT_Human1.20843685
104CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20722550
105ER_23166858_ChIP-Seq_MCF-7_Human1.18667359
106SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18051890
107FUS_26573619_Chip-Seq_HEK293_Human1.15581654
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15478846
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14925063
110POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14009986
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13652627
112P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12663239
113TP53_22573176_ChIP-Seq_HFKS_Human1.11691280
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11488501
115KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10985007
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10245427
117PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09466948
118FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09248697
119STAT3_23295773_ChIP-Seq_U87_Human1.08115683
120NANOG_16153702_ChIP-ChIP_HESCs_Human1.08013091
121YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06509086
122NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04815387
123CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04638536
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03610567
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03610567
126AHR_22903824_ChIP-Seq_MCF-7_Human1.03217300
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01959503
128RUNX2_22187159_ChIP-Seq_PCA_Human1.01803236
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01385758
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00727457
131LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00719534
132NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98097230
133TCF4_23295773_ChIP-Seq_U87_Human0.98024329
134E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97905577
135ELK1_22589737_ChIP-Seq_MCF10A_Human0.97814925
136ARNT_22903824_ChIP-Seq_MCF-7_Human0.97371401
137UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97342091
138MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97167749
139STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96931070
140KDM5A_27292631_Chip-Seq_BREAST_Human0.96539693
141IGF1R_20145208_ChIP-Seq_DFB_Human0.96535506
142STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95463864
143AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95205289
144SOX2_21211035_ChIP-Seq_LN229_Gbm0.95202320
145RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94160714
146GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94036946
147FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93965746
148TAL1_26923725_Chip-Seq_HPCs_Mouse0.93746758
149WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92730847
150CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91914285
151FOXP1_21924763_ChIP-Seq_HESCs_Human0.91681934
152POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91550926
153DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91188106
154LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90720602
155NANOG_18555785_Chip-Seq_ESCs_Mouse0.90665137
156SOX9_26525672_Chip-Seq_HEART_Mouse0.89644512
157VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89563186
158E2F1_17053090_ChIP-ChIP_MCF-7_Human0.89529486
159TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89171313
160HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89048651
161EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88655867
162* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.87980149
163CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87699814
164JUN_21703547_ChIP-Seq_K562_Human0.87500571
165CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87351108
166TP53_20018659_ChIP-ChIP_R1E_Mouse0.86323617
167* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85964979
168SMAD3_21741376_ChIP-Seq_ESCs_Human0.85130209
169PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.84816202
170KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.84258516
171NANOG_18555785_ChIP-Seq_MESCs_Mouse0.83887598
172* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83587911
173PRDM14_20953172_ChIP-Seq_ESCs_Human0.83376674
174P53_22387025_ChIP-Seq_ESCs_Mouse0.83219119
175NCOR_22424771_ChIP-Seq_293T_Human0.83215113
176EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83152739
177ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82514949
178PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82197668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.61707164
2MP0001984_abnormal_olfaction4.52525194
3MP0004859_abnormal_synaptic_plasticity3.35595673
4MP0004270_analgesia3.11743423
5MP0009379_abnormal_foot_pigmentation2.87749233
6MP0003635_abnormal_synaptic_transmissio2.75378725
7MP0002272_abnormal_nervous_system2.54573141
8MP0001486_abnormal_startle_reflex2.53347510
9MP0002734_abnormal_mechanical_nocicepti2.49016756
10MP0002064_seizures2.46019104
11MP0009046_muscle_twitch2.42866803
12MP0009745_abnormal_behavioral_response2.39266845
13MP0001968_abnormal_touch/_nociception2.23210689
14MP0002063_abnormal_learning/memory/cond2.22254974
15MP0000778_abnormal_nervous_system2.20562953
16MP0003136_yellow_coat_color2.18031846
17MP0002572_abnormal_emotion/affect_behav2.12431641
18MP0001293_anophthalmia2.11439157
19MP0002938_white_spotting2.03425590
20MP0002234_abnormal_pharynx_morphology2.02650192
21MP0004742_abnormal_vestibular_system1.99734213
22MP0000920_abnormal_myelination1.95622077
23MP0001485_abnormal_pinna_reflex1.94409146
24MP0005645_abnormal_hypothalamus_physiol1.93474706
25MP0005423_abnormal_somatic_nervous1.91759985
26MP0002184_abnormal_innervation1.90751957
27MP0008058_abnormal_DNA_repair1.89580450
28MP0003121_genomic_imprinting1.89152454
29MP0005410_abnormal_fertilization1.81660015
30MP0002736_abnormal_nociception_after1.79214696
31MP0006276_abnormal_autonomic_nervous1.77643912
32MP0002067_abnormal_sensory_capabilities1.76902811
33MP0005394_taste/olfaction_phenotype1.75846036
34MP0005499_abnormal_olfactory_system1.75846036
35MP0001529_abnormal_vocalization1.72729493
36MP0008877_abnormal_DNA_methylation1.68473769
37MP0002735_abnormal_chemical_nociception1.68069075
38MP0001905_abnormal_dopamine_level1.66176939
39MP0002557_abnormal_social/conspecific_i1.64896373
40MP0008789_abnormal_olfactory_epithelium1.64082174
41MP0001970_abnormal_pain_threshold1.63323963
42MP0002882_abnormal_neuron_morphology1.59849590
43MP0002822_catalepsy1.59764290
44MP0001440_abnormal_grooming_behavior1.55972818
45MP0002653_abnormal_ependyma_morphology1.52884363
46MP0002638_abnormal_pupillary_reflex1.52635964
47MP0005551_abnormal_eye_electrophysiolog1.52275041
48MP0005646_abnormal_pituitary_gland1.51888869
49MP0004142_abnormal_muscle_tone1.46343528
50MP0001188_hyperpigmentation1.45752103
51MP0002752_abnormal_somatic_nervous1.45209361
52MP0005171_absent_coat_pigmentation1.42384812
53MP0003283_abnormal_digestive_organ1.40809405
54MP0000955_abnormal_spinal_cord1.40139088
55MP0008995_early_reproductive_senescence1.38595291
56MP0002733_abnormal_thermal_nociception1.38162499
57MP0002282_abnormal_trachea_morphology1.35363418
58MP0005253_abnormal_eye_physiology1.33418414
59MP0005623_abnormal_meninges_morphology1.32409017
60MP0002229_neurodegeneration1.32316787
61MP0001501_abnormal_sleep_pattern1.30030352
62MP0003329_amyloid_beta_deposits1.27575902
63MP0003634_abnormal_glial_cell1.27314542
64MP0008875_abnormal_xenobiotic_pharmacok1.26300700
65MP0005084_abnormal_gallbladder_morpholo1.26233188
66MP0004924_abnormal_behavior1.26189252
67MP0005386_behavior/neurological_phenoty1.26189252
68MP0003122_maternal_imprinting1.25278791
69MP0004885_abnormal_endolymph1.25174863
70MP0003011_delayed_dark_adaptation1.24476340
71MP0001963_abnormal_hearing_physiology1.24217636
72MP0002066_abnormal_motor_capabilities/c1.20221876
73MP0008569_lethality_at_weaning1.18986830
74MP0004381_abnormal_hair_follicle1.17818358
75MP0002152_abnormal_brain_morphology1.14832001
76MP0004811_abnormal_neuron_physiology1.14539480
77MP0000631_abnormal_neuroendocrine_gland1.14352164
78MP0000566_synostosis1.12446760
79MP0000026_abnormal_inner_ear1.12281362
80MP0005409_darkened_coat_color1.12081264
81MP0001286_abnormal_eye_development1.11807409
82MP0010094_abnormal_chromosome_stability1.11189783
83MP0003718_maternal_effect1.08395778
84MP0003938_abnormal_ear_development1.07911674
85MP0008932_abnormal_embryonic_tissue1.07209463
86MP0002210_abnormal_sex_determination1.07165137
87MP0004145_abnormal_muscle_electrophysio1.07142196
88MP0002928_abnormal_bile_duct1.06275884
89MP0003119_abnormal_digestive_system1.03099210
90MP0005391_vision/eye_phenotype1.01139240
91MP0002277_abnormal_respiratory_mucosa1.00883767
92MP0004133_heterotaxia1.00534874
93MP0001929_abnormal_gametogenesis0.97457468
94MP0006035_abnormal_mitochondrial_morpho0.97130589
95MP0003890_abnormal_embryonic-extraembry0.96978089
96MP0003693_abnormal_embryo_hatching0.96836215
97MP0004858_abnormal_nervous_system0.95355143
98MP0001502_abnormal_circadian_rhythm0.92706284
99MP0003186_abnormal_redox_activity0.92433430
100MP0000372_irregular_coat_pigmentation0.91776900
101MP0003315_abnormal_perineum_morphology0.91411805
102MP0002163_abnormal_gland_morphology0.90288688
103MP0002697_abnormal_eye_size0.90216765
104MP0002837_dystrophic_cardiac_calcinosis0.89308359
105MP0001346_abnormal_lacrimal_gland0.89140972
106MP0009250_abnormal_appendicular_skeleto0.88827754
107MP0002751_abnormal_autonomic_nervous0.88474122
108MP0003878_abnormal_ear_physiology0.87388099
109MP0005377_hearing/vestibular/ear_phenot0.87388099
110MP0000653_abnormal_sex_gland0.87100383
111MP0002102_abnormal_ear_morphology0.86599081
112MP0003633_abnormal_nervous_system0.86590661
113MP0001145_abnormal_male_reproductive0.86164617
114MP0003786_premature_aging0.85755088
115MP0010030_abnormal_orbit_morphology0.85720802
116MP0010386_abnormal_urinary_bladder0.85532318
117MP0000049_abnormal_middle_ear0.84389055
118MP0003950_abnormal_plasma_membrane0.83483384
119MP0003861_abnormal_nervous_system0.83149066
120MP0002233_abnormal_nose_morphology0.83075523
121MP0003787_abnormal_imprinting0.81745389
122MP0003942_abnormal_urinary_system0.81461419
123MP0005195_abnormal_posterior_eye0.81227084
124MP0003879_abnormal_hair_cell0.80735818
125MP0002160_abnormal_reproductive_system0.80674411
126MP0003631_nervous_system_phenotype0.80366789
127MP0003690_abnormal_glial_cell0.79716518
128MP0003698_abnormal_male_reproductive0.78775371
129MP0003137_abnormal_impulse_conducting0.78312346
130MP0006072_abnormal_retinal_apoptosis0.77157250
131MP0000762_abnormal_tongue_morphology0.76445448
132MP0006292_abnormal_olfactory_placode0.73595090
133MP0001986_abnormal_taste_sensitivity0.72799733
134MP0001299_abnormal_eye_distance/0.70768181
135MP0003937_abnormal_limbs/digits/tail_de0.69133656
136MP0001177_atelectasis0.67610908
137MP0003755_abnormal_palate_morphology0.66670512

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.74294184
2Abnormal respiratory motile cilium physiology (HP:0012261)5.17986845
3Abnormal ciliary motility (HP:0012262)5.12004374
4Focal motor seizures (HP:0011153)4.64035048
5Abnormal respiratory epithelium morphology (HP:0012253)4.55451615
6Abnormal respiratory motile cilium morphology (HP:0005938)4.55451615
7Dynein arm defect of respiratory motile cilia (HP:0012255)4.48616102
8Absent/shortened dynein arms (HP:0200106)4.48616102
9Myokymia (HP:0002411)4.26204907
10Atonic seizures (HP:0010819)4.22079185
11True hermaphroditism (HP:0010459)4.10472125
12Pancreatic fibrosis (HP:0100732)4.10219322
13Retinal dysplasia (HP:0007973)3.79983383
14Rhinitis (HP:0012384)3.79721325
15Pancreatic cysts (HP:0001737)3.77878791
16Epileptic encephalopathy (HP:0200134)3.59428371
17Reticulocytopenia (HP:0001896)3.46045876
18Focal seizures (HP:0007359)3.42937397
19Febrile seizures (HP:0002373)3.35660727
20Limb dystonia (HP:0002451)3.26250582
21Acute encephalopathy (HP:0006846)3.20068435
22Abnormal number of erythroid precursors (HP:0012131)3.09577034
23Increased hepatocellular lipid droplets (HP:0006565)3.07389328
24Sensory axonal neuropathy (HP:0003390)3.04137103
25Hepatocellular necrosis (HP:0001404)3.01525862
26Abnormality of cells of the erythroid lineage (HP:0012130)3.00412914
27Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.99385291
28Degeneration of the lateral corticospinal tracts (HP:0002314)2.99385291
29Occipital encephalocele (HP:0002085)2.98873198
30Hyperventilation (HP:0002883)2.95623741
31Medial flaring of the eyebrow (HP:0010747)2.91637178
32Lipid accumulation in hepatocytes (HP:0006561)2.90719646
33Increased CSF lactate (HP:0002490)2.88985031
34Absence seizures (HP:0002121)2.88468837
35Gait imbalance (HP:0002141)2.88103298
36Neurofibrillary tangles (HP:0002185)2.85552466
37Cystic liver disease (HP:0006706)2.81948047
38Anencephaly (HP:0002323)2.78617877
39Dialeptic seizures (HP:0011146)2.77819373
40Sclerocornea (HP:0000647)2.77280250
41Broad-based gait (HP:0002136)2.72546427
42Parakeratosis (HP:0001036)2.71461708
43Bronchiectasis (HP:0002110)2.70007455
44Hepatic necrosis (HP:0002605)2.69514688
45Abnormality of the renal medulla (HP:0100957)2.65895564
46Congenital primary aphakia (HP:0007707)2.65095829
47Vaginal atresia (HP:0000148)2.62231817
48Postaxial foot polydactyly (HP:0001830)2.57050263
49Supranuclear gaze palsy (HP:0000605)2.56937047
50Colon cancer (HP:0003003)2.56033049
51Renal Fanconi syndrome (HP:0001994)2.56009297
52Genital tract atresia (HP:0001827)2.53904045
53Aplasia/Hypoplasia of the tongue (HP:0010295)2.52819374
54Nephrogenic diabetes insipidus (HP:0009806)2.40720163
55Abnormality of the labia minora (HP:0012880)2.36182095
56Abnormality of macular pigmentation (HP:0008002)2.35745995
57Chronic hepatic failure (HP:0100626)2.34940841
58Abnormality of the corticospinal tract (HP:0002492)2.33652583
59Peripheral hypomyelination (HP:0007182)2.32675627
60Cerebral edema (HP:0002181)2.31637646
61Hyperglycinemia (HP:0002154)2.31436459
62Alacrima (HP:0000522)2.31193956
63Dysmetria (HP:0001310)2.29938389
64Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.29807227
65Cerebral inclusion bodies (HP:0100314)2.27159946
66Chronic bronchitis (HP:0004469)2.26916383
67Generalized tonic-clonic seizures (HP:0002069)2.25864139
68Dysphonia (HP:0001618)2.19612053
69Abnormality of midbrain morphology (HP:0002418)2.19348467
70Molar tooth sign on MRI (HP:0002419)2.19348467
71Congenital hepatic fibrosis (HP:0002612)2.18908868
72Termporal pattern (HP:0011008)2.17703945
73Insidious onset (HP:0003587)2.17703945
74Preaxial hand polydactyly (HP:0001177)2.17696950
75Concave nail (HP:0001598)2.17608991
76Anophthalmia (HP:0000528)2.17192956
77Thickened helices (HP:0000391)2.12987666
78Pheochromocytoma (HP:0002666)2.11843048
79Male pseudohermaphroditism (HP:0000037)2.11659433
80Specific learning disability (HP:0001328)2.10410564
81Macrocytic anemia (HP:0001972)2.10206478
82Split foot (HP:0001839)2.09987184
83Nephronophthisis (HP:0000090)2.08642794
84Gaze-evoked nystagmus (HP:0000640)2.05386937
85Spastic gait (HP:0002064)2.02625318
86Cerebral hypomyelination (HP:0006808)2.02282605
87Megalencephaly (HP:0001355)1.99783907
88Decreased lacrimation (HP:0000633)1.99358579
89Aplasia/Hypoplasia of the lens (HP:0008063)1.97359406
903-Methylglutaconic aciduria (HP:0003535)1.95663797
91Acute necrotizing encephalopathy (HP:0006965)1.95503572
92Atelectasis (HP:0100750)1.93089619
93Neuroendocrine neoplasm (HP:0100634)1.91982682
94Amblyopia (HP:0000646)1.91644377
95Progressive cerebellar ataxia (HP:0002073)1.91569621
96Exercise intolerance (HP:0003546)1.90715711
97Ankle clonus (HP:0011448)1.90692847
98Increased intramyocellular lipid droplets (HP:0012240)1.90335728
99Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90131953
100Lactic acidosis (HP:0003128)1.89478752
101Supernumerary spleens (HP:0009799)1.88729441
102Holoprosencephaly (HP:0001360)1.86964303
103Hypothermia (HP:0002045)1.86716133
104Broad foot (HP:0001769)1.86515983
105Poor coordination (HP:0002370)1.85686473
106Increased serum lactate (HP:0002151)1.83991715
107Aplasia involving bones of the extremities (HP:0009825)1.82890318
108Aplasia involving bones of the upper limbs (HP:0009823)1.82890318
109Aplasia of the phalanges of the hand (HP:0009802)1.82890318
110Abnormal biliary tract physiology (HP:0012439)1.81686903
111Bile duct proliferation (HP:0001408)1.81686903
112Chronic sinusitis (HP:0011109)1.81538980
113Torticollis (HP:0000473)1.81012117
114Abnormal hair whorl (HP:0010721)1.80488591
115Aganglionic megacolon (HP:0002251)1.80472305
116Decreased testicular size (HP:0008734)1.80307834
117Visual hallucinations (HP:0002367)1.78145836
118Absent septum pellucidum (HP:0001331)1.77996544
119Optic nerve hypoplasia (HP:0000609)1.77258550
120Akinesia (HP:0002304)1.77103013
121Absent speech (HP:0001344)1.76319846
122Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.75723571
123Tubular atrophy (HP:0000092)1.74923250
124Lissencephaly (HP:0001339)1.74155972
125Respiratory failure (HP:0002878)1.73850759
126Progressive macrocephaly (HP:0004481)1.73680001
127Aplasia/Hypoplasia of the spleen (HP:0010451)1.72915754
128Absent thumb (HP:0009777)1.72381704
129Delusions (HP:0000746)1.71364675
130Bifid tongue (HP:0010297)1.71051407
131Triphalangeal thumb (HP:0001199)1.70783999
132Optic disc pallor (HP:0000543)1.70401128
133Exertional dyspnea (HP:0002875)1.69381427
134Rib fusion (HP:0000902)1.69349305
135Myelomeningocele (HP:0002475)1.68939488
136Humeroradial synostosis (HP:0003041)1.68770263
137Synostosis involving the elbow (HP:0003938)1.68770263
138Hyperthyroidism (HP:0000836)1.68191036
139Progressive inability to walk (HP:0002505)1.68065503
140Tubulointerstitial nephritis (HP:0001970)1.67502385
141Optic nerve coloboma (HP:0000588)1.67065561
142Anxiety (HP:0000739)1.66714010
143Septo-optic dysplasia (HP:0100842)1.66409317
144Mitochondrial inheritance (HP:0001427)1.65240283
145Abnormality of renal resorption (HP:0011038)1.65033673
146Methylmalonic aciduria (HP:0012120)1.64754392
147Nasal polyposis (HP:0100582)1.64638974
148Focal dystonia (HP:0004373)1.64622257
149Leukodystrophy (HP:0002415)1.64404122
150Abnormality of the septum pellucidum (HP:0007375)1.64301411
151Stenosis of the external auditory canal (HP:0000402)1.64255689
152Coronal craniosynostosis (HP:0004440)1.64180858
153Abnormality of glycolysis (HP:0004366)1.64047732
154Oculomotor apraxia (HP:0000657)1.63840495
155Abnormal mitochondria in muscle tissue (HP:0008316)1.63831072
156Depressed nasal ridge (HP:0000457)1.63454165
157Maternal diabetes (HP:0009800)1.63354790
158Postaxial hand polydactyly (HP:0001162)1.63207144
159Narrow forehead (HP:0000341)1.62073190
160Infertility (HP:0000789)1.61741562
161Craniofacial dystonia (HP:0012179)1.61441622
162Generalized myoclonic seizures (HP:0002123)1.61075699
163Poor suck (HP:0002033)1.60983329
164Abnormal auditory evoked potentials (HP:0006958)1.60548906
165Polyphagia (HP:0002591)1.60007986
166Lower limb muscle weakness (HP:0007340)1.59385121
167Action tremor (HP:0002345)1.58765357
168Type II lissencephaly (HP:0007260)1.58206549
169Dysdiadochokinesis (HP:0002075)1.58189670

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.92232757
2CASK4.28974804
3STK393.55453610
4CDK193.35890621
5BCKDK3.17326928
6PRPF4B2.96767259
7OXSR12.87046254
8EPHA42.80746523
9VRK12.57897465
10ZAK2.47914921
11BUB12.27849652
12PNCK2.19177285
13NTRK32.16850851
14MAP4K22.10166015
15BCR2.07882229
16NUAK12.03568728
17WNK32.00405612
18TRIM281.98846402
19TLK11.98317760
20PHKG21.96260474
21PHKG11.96260474
22CDC71.89185967
23TNIK1.82484853
24MAP3K41.79178609
25DAPK21.76177126
26ICK1.76097545
27MAP2K71.74381422
28TAF11.64057172
29CAMK2B1.58575473
30SRPK11.57132902
31WNK41.56168680
32MARK11.55061778
33UHMK11.55014827
34PASK1.50448430
35ARAF1.49738462
36NTRK11.47411361
37DYRK31.45791323
38PLK41.38018018
39MAPK131.32250322
40NTRK21.31447909
41MINK11.31252442
42WNK11.30223923
43PLK31.29292027
44PKN11.28906980
45MAP3K91.23789611
46MAPK151.22785751
47CAMK2D1.22351710
48CSNK1A1L1.20148473
49STK161.19988544
50CSNK1G31.18988619
51GRK51.18802550
52CDK51.14146715
53INSRR1.12186233
54CAMK2A1.10120729
55PAK61.09610690
56PAK31.09198607
57PRKD31.08949419
58TTK1.08479033
59FGR1.08418576
60PLK21.08190053
61PLK11.05939920
62GRK11.04368870
63TYRO31.04300614
64LIMK11.03974476
65NEK61.03931892
66NEK11.02273576
67AURKA1.01815550
68SGK2231.01273626
69SGK4941.01273626
70CSNK1G21.00793783
71MUSK1.00077003
72MAPKAPK50.99842465
73CAMK2G0.97513354
74MST40.97270654
75CDK80.97256712
76WEE10.95972039
77IRAK20.95266940
78TNK20.92770697
79TESK20.89067451
80ATR0.88718874
81CSNK1G10.88662965
82MKNK10.88196710
83PRKCG0.87713618
84CDK140.86778150
85ROCK20.85386130
86BMPR20.83126394
87BRAF0.83104880
88KDR0.82195261
89AKT30.80084330
90TIE10.79618138
91FGFR20.79478524
92CDK180.78997673
93MAP2K40.78630166
94FES0.78601220
95CHEK20.76937306
96NME10.76655871
97CCNB10.76021221
98PTK2B0.75795361
99DYRK1A0.75497642
100CDK150.75359823
101BMPR1B0.75074083
102NEK20.74806699
103AURKB0.74798639
104IRAK10.74510202
105CDK11A0.74051439
106MET0.71696071
107MARK20.69766940
108MKNK20.69453244
109PRKCE0.69282126
110RPS6KA50.67797197
111ADRBK20.66225247
112EPHB20.66191417
113BRSK10.65915950
114DYRK1B0.65184321
115KSR10.64381815
116PINK10.62526806
117DAPK30.61523850
118PIM20.60200205
119NME20.59817725
120SIK30.58763427
121TGFBR10.56111504
122RPS6KA40.54765623
123ERBB30.53342063
124CAMK10.48722008
125DYRK20.48333735
126CSNK2A10.47158226
127STK110.47151765
128CSNK2A20.46938300
129TESK10.45732974
130EPHA30.45673329
131GRK70.44252044
132TSSK60.43482867
133FER0.42146180
134LRRK20.41119503
135EPHA20.41096871
136PRKCI0.40849412
137PDPK10.40413920
138CDK30.39626874
139PRKG10.39442255
140PRKACA0.39282866
141FYN0.39049658
142PRKD20.38782628
143CSNK1A10.38570482
144MAP3K120.38249256
145EIF2AK20.37804222
146PBK0.37772181
147SIK20.37743817
148DDR20.37160195
149KSR20.36110680
150ADRBK10.35832061
151EIF2AK30.35816399
152ATM0.35176396
153CSNK1E0.34365385

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047404.73962177
2Ribosome_Homo sapiens_hsa030104.31230380
3Proteasome_Homo sapiens_hsa030502.91649000
4Nicotine addiction_Homo sapiens_hsa050332.86112945
5Synaptic vesicle cycle_Homo sapiens_hsa047212.68746554
6Phototransduction_Homo sapiens_hsa047442.64866661
7Mismatch repair_Homo sapiens_hsa034302.51589050
8Morphine addiction_Homo sapiens_hsa050322.47693013
9Oxidative phosphorylation_Homo sapiens_hsa001902.47219519
10GABAergic synapse_Homo sapiens_hsa047272.43309141
11RNA polymerase_Homo sapiens_hsa030202.36380080
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.33776227
13Collecting duct acid secretion_Homo sapiens_hsa049662.27978780
14Homologous recombination_Homo sapiens_hsa034402.23078086
15DNA replication_Homo sapiens_hsa030302.23065067
16Glutamatergic synapse_Homo sapiens_hsa047242.20883921
17Circadian entrainment_Homo sapiens_hsa047132.17948578
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.14592597
19Base excision repair_Homo sapiens_hsa034102.09523510
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.06387036
21Taste transduction_Homo sapiens_hsa047421.98344372
22Parkinsons disease_Homo sapiens_hsa050121.94418114
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.92041840
24Dopaminergic synapse_Homo sapiens_hsa047281.91878511
25Serotonergic synapse_Homo sapiens_hsa047261.90091615
26Fanconi anemia pathway_Homo sapiens_hsa034601.89782932
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.78851263
28Amphetamine addiction_Homo sapiens_hsa050311.77588713
29Axon guidance_Homo sapiens_hsa043601.76809198
30Alzheimers disease_Homo sapiens_hsa050101.70402495
31Nucleotide excision repair_Homo sapiens_hsa034201.68395752
32Vibrio cholerae infection_Homo sapiens_hsa051101.67878424
33Long-term potentiation_Homo sapiens_hsa047201.62514449
34Propanoate metabolism_Homo sapiens_hsa006401.61134092
35Salivary secretion_Homo sapiens_hsa049701.59679034
36Cholinergic synapse_Homo sapiens_hsa047251.53050162
37Insulin secretion_Homo sapiens_hsa049111.52998149
38Cardiac muscle contraction_Homo sapiens_hsa042601.51114339
39Pyrimidine metabolism_Homo sapiens_hsa002401.50962995
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.46946945
41Spliceosome_Homo sapiens_hsa030401.44771781
42Long-term depression_Homo sapiens_hsa047301.44646151
43Renin secretion_Homo sapiens_hsa049241.39579038
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39399260
45Gastric acid secretion_Homo sapiens_hsa049711.38860996
46RNA degradation_Homo sapiens_hsa030181.37797255
47Cocaine addiction_Homo sapiens_hsa050301.36809599
48Ether lipid metabolism_Homo sapiens_hsa005651.33514791
49Sulfur relay system_Homo sapiens_hsa041221.33066806
50Huntingtons disease_Homo sapiens_hsa050161.30229864
51Calcium signaling pathway_Homo sapiens_hsa040201.29647874
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27144437
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19941055
54Purine metabolism_Homo sapiens_hsa002301.19650529
55Steroid biosynthesis_Homo sapiens_hsa001001.17583436
56Basal transcription factors_Homo sapiens_hsa030221.16602125
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16477955
58Sphingolipid metabolism_Homo sapiens_hsa006001.16403142
59Butanoate metabolism_Homo sapiens_hsa006501.16066604
60Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14090317
61Melanogenesis_Homo sapiens_hsa049161.11350851
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10793062
63cAMP signaling pathway_Homo sapiens_hsa040241.09618167
64Folate biosynthesis_Homo sapiens_hsa007901.08926009
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08880978
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08813285
67Gap junction_Homo sapiens_hsa045401.08079773
68Fatty acid elongation_Homo sapiens_hsa000621.07780886
69Oxytocin signaling pathway_Homo sapiens_hsa049211.07416483
70Peroxisome_Homo sapiens_hsa041461.06491349
71Cysteine and methionine metabolism_Homo sapiens_hsa002701.04674790
72Glutathione metabolism_Homo sapiens_hsa004801.01939103
73RNA transport_Homo sapiens_hsa030131.01690386
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99948842
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99844577
76Phenylalanine metabolism_Homo sapiens_hsa003600.99761460
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99294793
78GnRH signaling pathway_Homo sapiens_hsa049120.96444163
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96271609
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95334985
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95164458
82Non-homologous end-joining_Homo sapiens_hsa034500.94090141
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92393713
84Biosynthesis of amino acids_Homo sapiens_hsa012300.92171648
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88243328
86Metabolic pathways_Homo sapiens_hsa011000.87899900
87Hedgehog signaling pathway_Homo sapiens_hsa043400.86704814
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.86592672
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86362894
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85820541
91Tyrosine metabolism_Homo sapiens_hsa003500.84869179
92beta-Alanine metabolism_Homo sapiens_hsa004100.84175523
93ErbB signaling pathway_Homo sapiens_hsa040120.83423748
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82598681
95Alcoholism_Homo sapiens_hsa050340.81852155
96One carbon pool by folate_Homo sapiens_hsa006700.80726446
97Chemical carcinogenesis_Homo sapiens_hsa052040.79964876
98Dorso-ventral axis formation_Homo sapiens_hsa043200.79237353
99Ras signaling pathway_Homo sapiens_hsa040140.77775306
100Carbon metabolism_Homo sapiens_hsa012000.76353928
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75833656
102Estrogen signaling pathway_Homo sapiens_hsa049150.73922715
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72981612
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.72477941
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71701354
106Wnt signaling pathway_Homo sapiens_hsa043100.71327570
107Tight junction_Homo sapiens_hsa045300.68954678
108Ovarian steroidogenesis_Homo sapiens_hsa049130.68714407
109Nitrogen metabolism_Homo sapiens_hsa009100.65501487
110Tryptophan metabolism_Homo sapiens_hsa003800.63420871
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62510343
112Cell cycle_Homo sapiens_hsa041100.61635363
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60654547
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59987405
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.59345486
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58366609
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55870024
118Pancreatic secretion_Homo sapiens_hsa049720.53962982
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.53573612
120Selenocompound metabolism_Homo sapiens_hsa004500.51600979
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51534221
122Oocyte meiosis_Homo sapiens_hsa041140.51090139
123MAPK signaling pathway_Homo sapiens_hsa040100.50504672
124Glioma_Homo sapiens_hsa052140.50367418
125Renal cell carcinoma_Homo sapiens_hsa052110.49732177
126Arginine and proline metabolism_Homo sapiens_hsa003300.48921055
127Protein export_Homo sapiens_hsa030600.47763029
128Rheumatoid arthritis_Homo sapiens_hsa053230.46722163
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46182584
130Dilated cardiomyopathy_Homo sapiens_hsa054140.45965271
131Basal cell carcinoma_Homo sapiens_hsa052170.44406142
132Sulfur metabolism_Homo sapiens_hsa009200.44238450
133Choline metabolism in cancer_Homo sapiens_hsa052310.43997578
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43759362
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42427924
136Rap1 signaling pathway_Homo sapiens_hsa040150.42317673
137Regulation of autophagy_Homo sapiens_hsa041400.41905906
138Retinol metabolism_Homo sapiens_hsa008300.41357856
139Mineral absorption_Homo sapiens_hsa049780.41122690
140Primary bile acid biosynthesis_Homo sapiens_hsa001200.40578071
141Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39780838
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39237286
143Thyroid hormone synthesis_Homo sapiens_hsa049180.36974636
144p53 signaling pathway_Homo sapiens_hsa041150.36420919
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.35068211
146Endocytosis_Homo sapiens_hsa041440.34802218
147Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34429822
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34010961
149mRNA surveillance pathway_Homo sapiens_hsa030150.33067886
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32720132
151Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31751077
152Linoleic acid metabolism_Homo sapiens_hsa005910.31410678
153Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30946191
154Steroid hormone biosynthesis_Homo sapiens_hsa001400.30170800
155Fructose and mannose metabolism_Homo sapiens_hsa000510.28882013
156Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28347957
157Systemic lupus erythematosus_Homo sapiens_hsa053220.28218309
158Melanoma_Homo sapiens_hsa052180.27198372
159N-Glycan biosynthesis_Homo sapiens_hsa005100.26700865
160Phagosome_Homo sapiens_hsa041450.26049373
161Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26033147
162Hippo signaling pathway_Homo sapiens_hsa043900.25554709
163Arachidonic acid metabolism_Homo sapiens_hsa005900.25526057
164Pyruvate metabolism_Homo sapiens_hsa006200.24512074
165Vitamin B6 metabolism_Homo sapiens_hsa007500.24433404
166Caffeine metabolism_Homo sapiens_hsa002320.24356876
167Inositol phosphate metabolism_Homo sapiens_hsa005620.20479096

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