WDR59

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)8.09608324
2doxorubicin metabolic process (GO:0044598)8.09608324
3daunorubicin metabolic process (GO:0044597)8.09608324
4high-density lipoprotein particle remodeling (GO:0034375)4.78407334
5aminoglycoside antibiotic metabolic process (GO:0030647)4.59724554
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.57035797
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.38803864
8reverse cholesterol transport (GO:0043691)4.34173116
9intestinal cholesterol absorption (GO:0030299)4.29407696
10locomotory exploration behavior (GO:0035641)4.25044243
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.15993193
12vocalization behavior (GO:0071625)4.12715976
13nephron tubule morphogenesis (GO:0072078)4.05669051
14nephron epithelium morphogenesis (GO:0072088)4.05669051
15protein-lipid complex remodeling (GO:0034368)4.02986536
16macromolecular complex remodeling (GO:0034367)4.02986536
17plasma lipoprotein particle remodeling (GO:0034369)4.02986536
18neuron cell-cell adhesion (GO:0007158)4.00930102
19regulation of glutamate receptor signaling pathway (GO:1900449)3.90081372
20regulation of synaptic vesicle exocytosis (GO:2000300)3.87235148
21cholesterol efflux (GO:0033344)3.84862693
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.81421632
23plasma lipoprotein particle assembly (GO:0034377)3.80920331
24very-low-density lipoprotein particle assembly (GO:0034379)3.80553371
25glycerophospholipid catabolic process (GO:0046475)3.78476470
26auditory receptor cell stereocilium organization (GO:0060088)3.78259565
27axonal fasciculation (GO:0007413)3.77366367
28response to pheromone (GO:0019236)3.72458306
29negative regulation of macroautophagy (GO:0016242)3.72202170
30C4-dicarboxylate transport (GO:0015740)3.69261119
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.67204362
32neuronal ion channel clustering (GO:0045161)3.64983040
33pre-miRNA processing (GO:0031054)3.60212146
34serine family amino acid catabolic process (GO:0009071)3.57855965
35ionotropic glutamate receptor signaling pathway (GO:0035235)3.56754948
36tryptophan catabolic process (GO:0006569)3.55282731
37indole-containing compound catabolic process (GO:0042436)3.55282731
38indolalkylamine catabolic process (GO:0046218)3.55282731
39positive regulation of neurological system process (GO:0031646)3.52631901
40aromatic amino acid family catabolic process (GO:0009074)3.47697049
41neuron recognition (GO:0008038)3.47668040
42negative regulation of sodium ion transport (GO:0010766)3.47323022
43plasma lipoprotein particle organization (GO:0071827)3.45369518
44low-density lipoprotein particle remodeling (GO:0034374)3.43965401
45forebrain neuron differentiation (GO:0021879)3.43627036
46cell migration in hindbrain (GO:0021535)3.43289566
47regulation of gene silencing by RNA (GO:0060966)3.42344043
48regulation of posttranscriptional gene silencing (GO:0060147)3.42344043
49regulation of gene silencing by miRNA (GO:0060964)3.42344043
50water-soluble vitamin biosynthetic process (GO:0042364)3.41263054
51negative regulation of meiosis (GO:0045835)3.40402749
52L-phenylalanine catabolic process (GO:0006559)3.39163157
53erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.39163157
54ganglion development (GO:0061548)3.38560430
55regulation of oxidative phosphorylation (GO:0002082)3.38137132
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.32885834
57cerebral cortex radially oriented cell migration (GO:0021799)3.30597589
58regulation of synaptic vesicle transport (GO:1902803)3.29391259
59detection of molecule of bacterial origin (GO:0032490)3.26939135
60cerebellar Purkinje cell differentiation (GO:0021702)3.21296385
61renal tubule morphogenesis (GO:0061333)3.18892477
62transepithelial transport (GO:0070633)3.18781747
63regulation of fibrinolysis (GO:0051917)3.18398304
64synaptic vesicle maturation (GO:0016188)3.18000250
65post-embryonic morphogenesis (GO:0009886)3.17836554
66protein carboxylation (GO:0018214)3.15304931
67peptidyl-glutamic acid carboxylation (GO:0017187)3.15304931
68fat-soluble vitamin catabolic process (GO:0042363)3.14081315
69vitamin catabolic process (GO:0009111)3.14081315
70synaptic vesicle endocytosis (GO:0048488)3.13542368
71regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.13174646
72kynurenine metabolic process (GO:0070189)3.12029127
73negative regulation of fibrinolysis (GO:0051918)3.11007493
74presynaptic membrane assembly (GO:0097105)3.09297034
75protein localization to synapse (GO:0035418)3.08706475
76basic amino acid transport (GO:0015802)3.08541216
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.07950721
78presynaptic membrane organization (GO:0097090)3.07285636
79triglyceride homeostasis (GO:0070328)3.05868619
80acylglycerol homeostasis (GO:0055090)3.05868619
81dendrite morphogenesis (GO:0048813)3.04813694
82regulation of cholesterol esterification (GO:0010872)3.02268647
83inner ear receptor stereocilium organization (GO:0060122)3.01760220
84cellular copper ion homeostasis (GO:0006878)3.01347427
85synaptic transmission, glutamatergic (GO:0035249)3.00792567
86protein-lipid complex subunit organization (GO:0071825)3.00304551
87vitamin transmembrane transport (GO:0035461)2.99187863
88L-fucose catabolic process (GO:0042355)2.98763237
89fucose catabolic process (GO:0019317)2.98763237
90L-fucose metabolic process (GO:0042354)2.98763237
91triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.98762399
92synaptic vesicle exocytosis (GO:0016079)2.98490975
93regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.95560731
94protein-lipid complex assembly (GO:0065005)2.94351134
95neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.90752768
96glycine metabolic process (GO:0006544)2.90233201
97regulation of bile acid biosynthetic process (GO:0070857)2.89208741
98negative regulation of astrocyte differentiation (GO:0048712)2.88345811
99head development (GO:0060322)2.87762915
100regulation of non-canonical Wnt signaling pathway (GO:2000050)2.87742986
101erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.86760737
102L-phenylalanine metabolic process (GO:0006558)2.86760737
103lung epithelium development (GO:0060428)2.85917811
104protein prenylation (GO:0018342)2.84681313
105prenylation (GO:0097354)2.84681313
106negative regulation of sterol transport (GO:0032372)2.84246239
107negative regulation of cholesterol transport (GO:0032375)2.84246239
108tryptophan metabolic process (GO:0006568)2.83257774
109postsynaptic membrane organization (GO:0001941)2.83069686
110detection of light stimulus involved in sensory perception (GO:0050962)2.82952836
111detection of light stimulus involved in visual perception (GO:0050908)2.82952836
112stress granule assembly (GO:0034063)2.82889611
113peptidyl-glutamic acid modification (GO:0018200)2.81544174
114positive regulation of synapse maturation (GO:0090129)2.80426293
115phosphatidylethanolamine metabolic process (GO:0046337)2.78406623
116exploration behavior (GO:0035640)2.76587815
117neurotransmitter secretion (GO:0007269)2.75425142
118positive regulation of hormone biosynthetic process (GO:0046886)2.74637349
119phospholipid efflux (GO:0033700)2.74531720
120positive regulation of synaptic transmission, GABAergic (GO:0032230)2.73928489
121negative regulation of neurotransmitter transport (GO:0051589)2.73815188
122regulation of hippo signaling (GO:0035330)2.73763889
123vesicle transport along microtubule (GO:0047496)2.73627722
124indolalkylamine metabolic process (GO:0006586)2.72298040
125energy homeostasis (GO:0097009)2.72181175
126dendritic spine morphogenesis (GO:0060997)2.72010913
127regulation of protein activation cascade (GO:2000257)2.70530492
128phosphatidylethanolamine biosynthetic process (GO:0006646)2.69663387
129positive regulation of fatty acid oxidation (GO:0046321)2.69505522
130regulation of nuclear cell cycle DNA replication (GO:0033262)2.69367953
131negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.68795656
132negative regulation of translation, ncRNA-mediated (GO:0040033)2.68795656
133regulation of translation, ncRNA-mediated (GO:0045974)2.68795656
134histone H3-K9 modification (GO:0061647)2.68506154
135regulation of skeletal muscle cell differentiation (GO:2001014)2.68252308
136alpha-amino acid catabolic process (GO:1901606)2.68020528
137neuron-neuron synaptic transmission (GO:0007270)2.67956762
138glutamate secretion (GO:0014047)2.67556552
139membrane hyperpolarization (GO:0060081)2.65510032
140regulation of synapse maturation (GO:0090128)2.65478546
141NAD biosynthetic process (GO:0009435)2.65368021
1423-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.64938566
143purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.64938566
144aromatic amino acid family metabolic process (GO:0009072)2.63899887
145innervation (GO:0060384)2.63828903
146craniofacial suture morphogenesis (GO:0097094)2.63156555
147L-alpha-amino acid transmembrane transport (GO:1902475)2.63054428
148exocrine pancreas development (GO:0031017)2.61831040
149cerebellum development (GO:0021549)2.61592394
150regulation of complement activation (GO:0030449)2.61567359
151homocysteine metabolic process (GO:0050667)2.61307010
152intestinal absorption (GO:0050892)2.60994297
153gamma-aminobutyric acid transport (GO:0015812)2.60757765
154glutamate receptor signaling pathway (GO:0007215)2.59700067
155plasma lipoprotein particle clearance (GO:0034381)2.58826143
156peristalsis (GO:0030432)2.58274516
157musculoskeletal movement (GO:0050881)2.57720724
158multicellular organismal movement (GO:0050879)2.57720724
159detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.57546375
160amine catabolic process (GO:0009310)2.57275294
161cellular biogenic amine catabolic process (GO:0042402)2.57275294
162heme transport (GO:0015886)2.56542642
163cellular ketone body metabolic process (GO:0046950)2.56440136
164positive regulation of dendritic spine morphogenesis (GO:0061003)2.56418950
165cholesterol transport (GO:0030301)2.56403161
166sterol transport (GO:0015918)2.56403161
167histone H3-K36 demethylation (GO:0070544)2.56036252
168drug catabolic process (GO:0042737)2.55532807
169behavioral response to nicotine (GO:0035095)2.55012795
170S-adenosylmethionine metabolic process (GO:0046500)2.52521929
171response to morphine (GO:0043278)2.51994511
172serine family amino acid metabolic process (GO:0009069)2.51436142
173positive regulation of dendrite morphogenesis (GO:0050775)2.50985378
174organelle transport along microtubule (GO:0072384)2.50364500
175cysteine metabolic process (GO:0006534)2.50010687
176proline transport (GO:0015824)2.49052702
177sulfate transmembrane transport (GO:1902358)2.48777222
178protein polyglutamylation (GO:0018095)2.48409630
179positive regulation of glycolytic process (GO:0045821)2.48319961
180positive regulation of CREB transcription factor activity (GO:0032793)2.47778355
181positive regulation of neurotransmitter secretion (GO:0001956)2.47433718
182kidney morphogenesis (GO:0060993)2.46176513
183adult walking behavior (GO:0007628)2.46176038
184regulation of neurotransmitter secretion (GO:0046928)2.45830092
185regulation of hexokinase activity (GO:1903299)2.45493022
186regulation of glucokinase activity (GO:0033131)2.45493022
187synapse assembly (GO:0007416)2.44833737
188central nervous system projection neuron axonogenesis (GO:0021952)2.44780439
189layer formation in cerebral cortex (GO:0021819)2.44509839
190positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.42790819
191nerve growth factor signaling pathway (GO:0038180)2.40857860
192histone H3-K4 trimethylation (GO:0080182)2.40526441
193response to isoquinoline alkaloid (GO:0014072)2.38439577
194estrogen biosynthetic process (GO:0006703)2.38340875
195transmission of nerve impulse (GO:0019226)2.38075320
196cranial suture morphogenesis (GO:0060363)2.37594301
197neuron remodeling (GO:0016322)2.36295674

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.68862506
2GBX2_23144817_ChIP-Seq_PC3_Human3.90611948
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.64966994
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.93324088
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.67728457
6IGF1R_20145208_ChIP-Seq_DFB_Human2.63896709
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.62630416
8DROSHA_22980978_ChIP-Seq_HELA_Human2.49871530
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38521943
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.35600084
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.34159920
12ZNF274_21170338_ChIP-Seq_K562_Hela2.29590423
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.28219812
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.25476076
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.24447381
16FOXA2_19822575_ChIP-Seq_HepG2_Human2.17954685
17* REST_21632747_ChIP-Seq_MESCs_Mouse2.16038252
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.15842756
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.15842756
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.14141379
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.13093298
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.11966250
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.04391688
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.04122567
25PCGF2_27294783_Chip-Seq_ESCs_Mouse2.02852567
26SALL1_21062744_ChIP-ChIP_HESCs_Human2.01453647
27JARID2_20075857_ChIP-Seq_MESCs_Mouse2.01430278
28EZH2_27304074_Chip-Seq_ESCs_Mouse2.01376214
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.00272730
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.98316800
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.92606228
32SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.92323525
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85649365
34CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.82432104
35* HNF4A_19822575_ChIP-Seq_HepG2_Human1.82326525
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.79878474
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.79798084
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.79335608
39TAF15_26573619_Chip-Seq_HEK293_Human1.77102165
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.74990672
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.73455788
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.73433491
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.72691241
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72611706
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72264722
46RXR_22158963_ChIP-Seq_LIVER_Mouse1.70699522
47LXR_22158963_ChIP-Seq_LIVER_Mouse1.70233818
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70203430
49MTF2_20144788_ChIP-Seq_MESCs_Mouse1.69137007
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68705064
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.65840472
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.65540487
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62902189
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.56265700
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.56262146
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55577970
57P300_19829295_ChIP-Seq_ESCs_Human1.55198883
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54272014
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54266902
60SMAD4_21799915_ChIP-Seq_A2780_Human1.53838907
61STAT3_23295773_ChIP-Seq_U87_Human1.50537699
62AR_21572438_ChIP-Seq_LNCaP_Human1.50344102
63TP53_16413492_ChIP-PET_HCT116_Human1.48761697
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.47129467
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46947434
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44583225
67KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44107838
68KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44107838
69KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44107838
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42709994
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.41724864
72TCF4_23295773_ChIP-Seq_U87_Human1.39601367
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39568214
74BCAT_22108803_ChIP-Seq_LS180_Human1.38949353
75HOXB7_26014856_ChIP-Seq_BT474_Human1.38927768
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38829703
77RNF2_27304074_Chip-Seq_NSC_Mouse1.37824881
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36918781
79IRF1_19129219_ChIP-ChIP_H3396_Human1.35833222
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33933301
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33371445
82VDR_22108803_ChIP-Seq_LS180_Human1.33180889
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33158325
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.32494555
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32398231
86FUS_26573619_Chip-Seq_HEK293_Human1.31545721
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30397376
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.30339186
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29765665
90NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29411585
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28264181
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.27936149
93AR_19668381_ChIP-Seq_PC3_Human1.25812646
94WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23868269
95ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22912650
96SMAD3_21741376_ChIP-Seq_ESCs_Human1.22711572
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22577439
98TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22564892
99SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21305122
100EWS_26573619_Chip-Seq_HEK293_Human1.21206307
101ERG_21242973_ChIP-ChIP_JURKAT_Human1.20754377
102GATA3_21878914_ChIP-Seq_MCF-7_Human1.20208350
103ERA_21632823_ChIP-Seq_H3396_Human1.19612561
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.18650048
105RUNX2_22187159_ChIP-Seq_PCA_Human1.17471253
106TP53_22573176_ChIP-Seq_HFKS_Human1.17354953
107OCT4_20526341_ChIP-Seq_ESCs_Human1.16726791
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14824847
109TP63_19390658_ChIP-ChIP_HaCaT_Human1.13959646
110RING1B_27294783_Chip-Seq_ESCs_Mouse1.13927469
111ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13597998
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13244838
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13056394
114PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12722998
115* ER_23166858_ChIP-Seq_MCF-7_Human1.12416433
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12393235
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12222749
118CBX2_27304074_Chip-Seq_ESCs_Mouse1.11846644
119ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11562790
120RAC3_21632823_ChIP-Seq_H3396_Human1.10395895
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10222821
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09602219
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09228923
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09228923
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08373645
126RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07741048
127MYC_19829295_ChIP-Seq_ESCs_Human1.07736351
128DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07610736
129AHR_22903824_ChIP-Seq_MCF-7_Human1.07564883
130EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07494664
131HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06896704
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06820163
133SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06729526
134FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06282669
135FOXA1_25329375_ChIP-Seq_VCAP_Human1.06282669
136ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06277053
137RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05459912
138RXR_22108803_ChIP-Seq_LS180_Human1.04994260
139ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03184712
140FOXH1_21741376_ChIP-Seq_ESCs_Human1.02859771
141ESR1_21235772_ChIP-Seq_MCF-7_Human1.02794751
142POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02111757
143WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02005310
144STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01227863
145ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00895756
146GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99520963
147NFE2_27457419_Chip-Seq_LIVER_Mouse0.99210805
148SMAD4_21741376_ChIP-Seq_EPCs_Human0.98075358
149UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97766204
150SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96886584
151* NCOR_22424771_ChIP-Seq_293T_Human0.96122265
152GATA4_25053715_ChIP-Seq_YYC3_Human0.95522307
153MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94993936
154SOX2_19829295_ChIP-Seq_ESCs_Human0.94291138
155NANOG_19829295_ChIP-Seq_ESCs_Human0.94291138
156FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93678930
157TCF4_22108803_ChIP-Seq_LS180_Human0.93335964
158CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89382032
159MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87417345
160WDR5_24793694_ChIP-Seq_LNCAP_Human0.86379487
161TDRD3_21172665_ChIP-Seq_MCF-7_Human0.86069529
162FLI1_21867929_ChIP-Seq_TH2_Mouse0.85031669
163SMAD4_21741376_ChIP-Seq_HESCs_Human0.83427931

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol3.71311727
2MP0004859_abnormal_synaptic_plasticity3.66591548
3MP0003195_calcinosis3.30004647
4MP0005423_abnormal_somatic_nervous2.95043428
5MP0005360_urolithiasis2.89998242
6MP0005365_abnormal_bile_salt2.86911274
7MP0003880_abnormal_central_pattern2.80393169
8MP0010329_abnormal_lipoprotein_level2.58037860
9MP0008875_abnormal_xenobiotic_pharmacok2.57396424
10MP0003635_abnormal_synaptic_transmissio2.53669398
11MP0002139_abnormal_hepatobiliary_system2.40808599
12MP0006276_abnormal_autonomic_nervous2.35297499
13MP0006292_abnormal_olfactory_placode2.32067186
14MP0004270_analgesia2.31357616
15MP0001486_abnormal_startle_reflex2.28004609
16MP0004043_abnormal_pH_regulation2.25588186
17MP0004742_abnormal_vestibular_system2.19328410
18MP0008877_abnormal_DNA_methylation2.15199553
19MP0001485_abnormal_pinna_reflex2.12872728
20MP0003879_abnormal_hair_cell2.08723796
21MP0002063_abnormal_learning/memory/cond2.07618771
22MP0002572_abnormal_emotion/affect_behav2.05266541
23MP0005377_hearing/vestibular/ear_phenot2.02221835
24MP0003878_abnormal_ear_physiology2.02221835
25MP0000778_abnormal_nervous_system2.01537174
26MP0009745_abnormal_behavioral_response2.00536250
27MP0002064_seizures2.00130247
28MP0009046_muscle_twitch1.96248709
29MP0009697_abnormal_copulation1.93758576
30MP0004858_abnormal_nervous_system1.92808106
31MP0003122_maternal_imprinting1.90159801
32MP0002184_abnormal_innervation1.89847234
33MP0002272_abnormal_nervous_system1.85918090
34MP0001501_abnormal_sleep_pattern1.83035977
35MP0002277_abnormal_respiratory_mucosa1.81377510
36MP0005085_abnormal_gallbladder_physiolo1.80665363
37MP0001440_abnormal_grooming_behavior1.78499834
38MP0002876_abnormal_thyroid_physiology1.76928557
39MP0002735_abnormal_chemical_nociception1.74642145
40MP0002557_abnormal_social/conspecific_i1.73726362
41MP0004133_heterotaxia1.72767514
42MP0003890_abnormal_embryonic-extraembry1.72448269
43MP0002734_abnormal_mechanical_nocicepti1.69672972
44MP0003123_paternal_imprinting1.67135711
45MP0002254_reproductive_system_inflammat1.63428998
46MP0002837_dystrophic_cardiac_calcinosis1.59911019
47MP0002733_abnormal_thermal_nociception1.59719201
48MP0008872_abnormal_physiological_respon1.59592233
49MP0000678_abnormal_parathyroid_gland1.59057534
50MP0001348_abnormal_lacrimal_gland1.57094751
51MP0004924_abnormal_behavior1.55884869
52MP0005386_behavior/neurological_phenoty1.55884869
53MP0003787_abnormal_imprinting1.54049159
54MP0006072_abnormal_retinal_apoptosis1.53821413
55MP0004885_abnormal_endolymph1.52847652
56MP0000569_abnormal_digit_pigmentation1.52099085
57MP0003646_muscle_fatigue1.51941713
58MP0005332_abnormal_amino_acid1.51341129
59MP0009780_abnormal_chondrocyte_physiolo1.44000143
60MP0000955_abnormal_spinal_cord1.43588250
61MP0000566_synostosis1.42870819
62MP0001666_abnormal_nutrient_absorption1.42277361
63MP0005220_abnormal_exocrine_pancreas1.42033084
64MP0005646_abnormal_pituitary_gland1.40960894
65MP0004811_abnormal_neuron_physiology1.39552414
66MP0004019_abnormal_vitamin_homeostasis1.38002454
67MP0003252_abnormal_bile_duct1.34783498
68MP0001299_abnormal_eye_distance/1.33450825
69MP0004147_increased_porphyrin_level1.31942990
70MP0002067_abnormal_sensory_capabilities1.30581024
71MP0001944_abnormal_pancreas_morphology1.29684082
72MP0003283_abnormal_digestive_organ1.28740178
73MP0002882_abnormal_neuron_morphology1.27971755
74MP0005394_taste/olfaction_phenotype1.26704098
75MP0005499_abnormal_olfactory_system1.26704098
76MP0001346_abnormal_lacrimal_gland1.26197214
77MP0003136_yellow_coat_color1.25865771
78MP0008004_abnormal_stomach_pH1.25247809
79MP0001970_abnormal_pain_threshold1.23904481
80MP0002638_abnormal_pupillary_reflex1.21926204
81MP0001661_extended_life_span1.20072663
82MP0005408_hypopigmentation1.19000687
83MP0001502_abnormal_circadian_rhythm1.17561902
84MP0002822_catalepsy1.16927621
85MP0003121_genomic_imprinting1.15917866
86MP0002066_abnormal_motor_capabilities/c1.13356821
87MP0003718_maternal_effect1.13162598
88MP0003868_abnormal_feces_composition1.11100486
89MP0001986_abnormal_taste_sensitivity1.08217084
90MP0010386_abnormal_urinary_bladder1.07971839
91MP0003183_abnormal_peptide_metabolism1.07615739
92MP0002751_abnormal_autonomic_nervous1.07234138
93MP0004142_abnormal_muscle_tone1.07161454
94MP0001764_abnormal_homeostasis1.06896373
95MP0009840_abnormal_foam_cell1.06884172
96MP0002909_abnormal_adrenal_gland1.06632001
97MP0000631_abnormal_neuroendocrine_gland1.06483969
98MP0002152_abnormal_brain_morphology1.04549587
99MP0003943_abnormal_hepatobiliary_system1.04490761
100MP0002118_abnormal_lipid_homeostasis1.02710120
101MP0005379_endocrine/exocrine_gland_phen1.02086009
102MP0002653_abnormal_ependyma_morphology1.01879791
103MP0005551_abnormal_eye_electrophysiolog1.01817923
104MP0002229_neurodegeneration1.01647487
105MP0003172_abnormal_lysosome_physiology1.00443812
106MP0008789_abnormal_olfactory_epithelium0.99898013
107MP0001968_abnormal_touch/_nociception0.99569540
108MP0003938_abnormal_ear_development0.99507568
109MP0001270_distended_abdomen0.99216313
110MP0003634_abnormal_glial_cell0.99046797
111MP0005636_abnormal_mineral_homeostasis0.98849826
112MP0000462_abnormal_digestive_system0.98786378
113MP0001293_anophthalmia0.97235454
114MP0002938_white_spotting0.96886032
115MP0000920_abnormal_myelination0.95889285
116MP0005670_abnormal_white_adipose0.95532502
117MP0005248_abnormal_Harderian_gland0.94980074
118MP0002233_abnormal_nose_morphology0.94869913
119MP0002089_abnormal_postnatal_growth/wei0.94278691
120MP0002160_abnormal_reproductive_system0.94192773
121MP0009384_cardiac_valve_regurgitation0.92854981
122MP0003861_abnormal_nervous_system0.92651293
123MP0008995_early_reproductive_senescence0.91937104
124MP0000383_abnormal_hair_follicle0.91293931
125MP0003632_abnormal_nervous_system0.89747227
126MP0003119_abnormal_digestive_system0.89301787
127MP0005448_abnormal_energy_balance0.89081937
128MP0002138_abnormal_hepatobiliary_system0.88871275
129MP0002078_abnormal_glucose_homeostasis0.86315833
130MP0002098_abnormal_vibrissa_morphology0.86016400
131MP0002693_abnormal_pancreas_physiology0.85038093
132MP0005253_abnormal_eye_physiology0.84892747
133MP0002163_abnormal_gland_morphology0.84397010
134MP0008569_lethality_at_weaning0.84013879
135MP0002249_abnormal_larynx_morphology0.83582958
136MP0003937_abnormal_limbs/digits/tail_de0.82575007
137MP0003698_abnormal_male_reproductive0.82484710
138MP0000613_abnormal_salivary_gland0.81980641
139MP0004134_abnormal_chest_morphology0.81944424
140MP0001963_abnormal_hearing_physiology0.81934459
141MP0000639_abnormal_adrenal_gland0.80820579
142MP0005195_abnormal_posterior_eye0.80814438
143MP0003567_abnormal_fetal_cardiomyocyte0.80181584
144MP0002752_abnormal_somatic_nervous0.78943676
145MP0005389_reproductive_system_phenotype0.77145154
146MP0003953_abnormal_hormone_level0.77102945
147MP0000427_abnormal_hair_cycle0.76237399
148MP0001186_pigmentation_phenotype0.75797205
149MP0003633_abnormal_nervous_system0.75697808
150MP0002396_abnormal_hematopoietic_system0.75230462
151MP0000609_abnormal_liver_physiology0.74822799
152MP0002069_abnormal_eating/drinking_beha0.74809994
153MP0003045_fibrosis0.74547399
154MP0003631_nervous_system_phenotype0.73774269
155MP0002234_abnormal_pharynx_morphology0.73526700
156MP0001756_abnormal_urination0.73330250
157MP0000516_abnormal_urinary_system0.72789913
158MP0005367_renal/urinary_system_phenotyp0.72789913
159MP0004272_abnormal_basement_membrane0.72549242
160MP0000653_abnormal_sex_gland0.68883267
161MP0001929_abnormal_gametogenesis0.68058481
162MP0005395_other_phenotype0.68055078
163MP0002736_abnormal_nociception_after0.65743083

Predicted human phenotypes

RankGene SetZ-score
1Unilateral renal agenesis (HP:0000122)4.33305023
2Parakeratosis (HP:0001036)4.21406644
3Absent eyebrow (HP:0002223)4.18226695
4Congenital stationary night blindness (HP:0007642)3.84770153
5Hypobetalipoproteinemia (HP:0003563)3.79575197
6Prolonged partial thromboplastin time (HP:0003645)3.78182603
7Deep venous thrombosis (HP:0002625)3.73068801
8Abnormality of the renal cortex (HP:0011035)3.22441630
9Absent eyelashes (HP:0000561)3.21351057
10Focal motor seizures (HP:0011153)3.20309722
11Epileptic encephalopathy (HP:0200134)3.12735756
12Abnormality of calcium-phosphate metabolism (HP:0100530)3.12483085
13Febrile seizures (HP:0002373)2.94696551
14Abnormal rod and cone electroretinograms (HP:0008323)2.94603697
15Myokymia (HP:0002411)2.94428899
16Abnormality of the corticospinal tract (HP:0002492)2.94368810
17Recurrent corneal erosions (HP:0000495)2.92893859
18Action tremor (HP:0002345)2.88214398
19Alopecia of scalp (HP:0002293)2.86377907
20Pancreatic cysts (HP:0001737)2.83330128
21Cheilitis (HP:0100825)2.78058973
22Hyperglycinuria (HP:0003108)2.74118709
23Molar tooth sign on MRI (HP:0002419)2.72244978
24Abnormality of midbrain morphology (HP:0002418)2.72244978
25Abnormality of dental color (HP:0011073)2.72135427
26Septo-optic dysplasia (HP:0100842)2.70134809
27Severe visual impairment (HP:0001141)2.68801222
28EEG with generalized epileptiform discharges (HP:0011198)2.64893789
29Epileptiform EEG discharges (HP:0011182)2.60483721
30Enlarged kidneys (HP:0000105)2.58227641
31Attenuation of retinal blood vessels (HP:0007843)2.57530559
32Renal cortical cysts (HP:0000803)2.56941383
33Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.54511118
34Hypsarrhythmia (HP:0002521)2.54105798
35Pancreatic islet-cell hyperplasia (HP:0004510)2.53054690
36Broad alveolar ridges (HP:0000187)2.51981955
37Abnormal biliary tract physiology (HP:0012439)2.51540988
38Bile duct proliferation (HP:0001408)2.51540988
39Progressive cerebellar ataxia (HP:0002073)2.50538954
40Intestinal atresia (HP:0011100)2.49959230
41Abnormality of serine family amino acid metabolism (HP:0010894)2.49702699
42Abnormality of glycine metabolism (HP:0010895)2.49702699
43Midline defect of the nose (HP:0004122)2.48843935
44Type II lissencephaly (HP:0007260)2.45635383
45Focal seizures (HP:0007359)2.45060858
46Ketosis (HP:0001946)2.44807275
47Acanthocytosis (HP:0001927)2.44299407
48Follicular hyperkeratosis (HP:0007502)2.42925722
49Impaired social interactions (HP:0000735)2.40214048
50Abnormal social behavior (HP:0012433)2.40214048
51Nephronophthisis (HP:0000090)2.39234005
52Hyperphosphatemia (HP:0002905)2.38827324
53Insomnia (HP:0100785)2.36733301
54Hyperacusis (HP:0010780)2.36055391
55Pancreatic fibrosis (HP:0100732)2.35098453
56Hypoglycemic coma (HP:0001325)2.34481764
57Pendular nystagmus (HP:0012043)2.34481136
58Drooling (HP:0002307)2.32419672
59Excessive salivation (HP:0003781)2.32419672
60Poor speech (HP:0002465)2.31568680
61Poor eye contact (HP:0000817)2.30348148
62Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30300128
63Overriding aorta (HP:0002623)2.29539096
64Absent septum pellucidum (HP:0001331)2.29370033
65Elfin facies (HP:0004428)2.28043608
66Hyperglycinemia (HP:0002154)2.26187820
67Joint hemorrhage (HP:0005261)2.26130043
68Abnormality of DNA repair (HP:0003254)2.25708517
69Abnormality of the renal medulla (HP:0100957)2.25114246
70Coronal craniosynostosis (HP:0004440)2.24394556
71Degeneration of the lateral corticospinal tracts (HP:0002314)2.24119772
72Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.24119772
73Cutaneous finger syndactyly (HP:0010554)2.20901695
74Abnormality of the diencephalon (HP:0010662)2.19134077
75Atonic seizures (HP:0010819)2.18609555
76Abnormality of the pubic bones (HP:0003172)2.18134190
77Cystic liver disease (HP:0006706)2.18032743
78True hermaphroditism (HP:0010459)2.17961409
79Visual hallucinations (HP:0002367)2.16919691
80Bilateral sensorineural hearing impairment (HP:0008619)2.16516642
81Chromsome breakage (HP:0040012)2.16402159
82Duplicated collecting system (HP:0000081)2.15886193
83Genetic anticipation (HP:0003743)2.11805818
84Neoplasm of the adrenal cortex (HP:0100641)2.11570400
85Astrocytoma (HP:0009592)2.10039353
86Abnormality of the astrocytes (HP:0100707)2.10039353
87Broad-based gait (HP:0002136)2.09616024
88Supranuclear gaze palsy (HP:0000605)2.09419348
89Ankle clonus (HP:0011448)2.09401899
90Hepatoblastoma (HP:0002884)2.09250360
91Spontaneous abortion (HP:0005268)2.09089617
92Ketoacidosis (HP:0001993)2.09066807
93Hypoglycemic seizures (HP:0002173)2.08986215
94Abnormality of aromatic amino acid family metabolism (HP:0004338)2.08531962
95Epidermoid cyst (HP:0200040)2.07894116
96Ectopic kidney (HP:0000086)2.07470447
97Tubular atrophy (HP:0000092)2.07414553
98Pheochromocytoma (HP:0002666)2.06270443
99Large for gestational age (HP:0001520)2.04391004
100Hyperlipoproteinemia (HP:0010980)2.03863976
101Hyperventilation (HP:0002883)2.03699795
102Postural tremor (HP:0002174)2.03107809
103Renovascular hypertension (HP:0100817)2.02262790
104Vertebral arch anomaly (HP:0008438)2.01465338
105Abnormality of the renal collecting system (HP:0004742)2.00824095
106Exotropia (HP:0000577)2.00024728
107Gaze-evoked nystagmus (HP:0000640)1.99595164
108Impaired vibration sensation in the lower limbs (HP:0002166)1.99229713
109Dysmetria (HP:0001310)1.98882548
110Hypolipoproteinemia (HP:0010981)1.98375969
111Abnormality of the aortic arch (HP:0012303)1.96090869
112Cerebellar dysplasia (HP:0007033)1.95729985
113Urinary urgency (HP:0000012)1.95567554
114Termporal pattern (HP:0011008)1.95036610
115Insidious onset (HP:0003587)1.95036610
116Lissencephaly (HP:0001339)1.94762371
117Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93862962
118Arthropathy (HP:0003040)1.93837336
119Absence seizures (HP:0002121)1.92852268
120Abnormality of the septum pellucidum (HP:0007375)1.91935218
121Widely spaced teeth (HP:0000687)1.91817429
122Bony spicule pigmentary retinopathy (HP:0007737)1.90523854
123Cutaneous syndactyly (HP:0012725)1.89748976
124Small epiphyses (HP:0010585)1.89562424
125Abnormality of the vitreous humor (HP:0004327)1.87851773
126Obsessive-compulsive behavior (HP:0000722)1.87638917
127Abnormality of endocrine pancreas physiology (HP:0012093)1.87394521
128Abnormality of the pancreatic islet cells (HP:0006476)1.87394521
129Abnormality of the ileum (HP:0001549)1.87112026
130Urinary bladder sphincter dysfunction (HP:0002839)1.86535208
131Gastroesophageal reflux (HP:0002020)1.86282428
132Abnormality of the labia minora (HP:0012880)1.84255998
133Macroorchidism (HP:0000053)1.84058857
134Menstrual irregularities (HP:0000858)1.83708655
135Protruding tongue (HP:0010808)1.83587909
136Abolished electroretinogram (ERG) (HP:0000550)1.82426672
137Abnormal drinking behavior (HP:0030082)1.82035395
138Polydipsia (HP:0001959)1.82035395
139Abnormality of salivation (HP:0100755)1.81341511
140Impaired smooth pursuit (HP:0007772)1.81337510
141Meckel diverticulum (HP:0002245)1.81119020
142Aplasia/Hypoplasia of the spleen (HP:0010451)1.80005025
143Aqueductal stenosis (HP:0002410)1.79139926
144Neoplasm of the oral cavity (HP:0100649)1.78887607
145Abnormality of ocular smooth pursuit (HP:0000617)1.77817554
146Medial flaring of the eyebrow (HP:0010747)1.77421676
147Renal duplication (HP:0000075)1.77228185
148Keratoconus (HP:0000563)1.76293507
149Increased corneal curvature (HP:0100692)1.76293507
150Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.76135545
151Absent speech (HP:0001344)1.75429449
152Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.74862724
153Abnormality of alanine metabolism (HP:0010916)1.74862724
154Hyperalaninemia (HP:0003348)1.74862724
155Bilateral microphthalmos (HP:0007633)1.74523989
156Spastic gait (HP:0002064)1.74471319
157Chronic hepatic failure (HP:0100626)1.74220379
158Abnormality of the nasal septum (HP:0000419)1.73196171
159Renal hypoplasia (HP:0000089)1.72901101
160Pigmentary retinal degeneration (HP:0001146)1.72596146
161Oligodontia (HP:0000677)1.72337326
162Hyperinsulinemic hypoglycemia (HP:0000825)1.72306762
163Neuroendocrine neoplasm (HP:0100634)1.72206156
164Aplasia/Hypoplasia of the fovea (HP:0008060)1.72101807
165Hypoplasia of the fovea (HP:0007750)1.72101807
166Hypothermia (HP:0002045)1.71753192
167Volvulus (HP:0002580)1.71346503
168Agitation (HP:0000713)1.70920789
169Autism (HP:0000717)1.70853116
170Bowel incontinence (HP:0002607)1.70568911
171Generalized tonic-clonic seizures (HP:0002069)1.70409409
172Postural instability (HP:0002172)1.70188341
173Abnormal urine output (HP:0012590)1.68723343
174Hypoplasia of the pons (HP:0012110)1.68162148
175Progressive inability to walk (HP:0002505)1.67468733
176Osteomalacia (HP:0002749)1.67463078
177Dysdiadochokinesis (HP:0002075)1.67450101
178Conjugated hyperbilirubinemia (HP:0002908)1.67403049
179Vesicoureteral reflux (HP:0000076)1.67339157
180Absent hair (HP:0002298)1.67319060
181Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.66961860
182Resting tremor (HP:0002322)1.66736255
183Irregular epiphyses (HP:0010582)1.66289144
184Rib fusion (HP:0000902)1.65876511
185Supernumerary spleens (HP:0009799)1.64591979
186Abnormal number of erythroid precursors (HP:0012131)1.63993530
187Xanthomatosis (HP:0000991)1.63241582
188Proximal tubulopathy (HP:0000114)1.62820282
189Hypercholesterolemia (HP:0003124)1.62607760
190Bronchomalacia (HP:0002780)1.62441345
191Abnormality of the wing of the ilium (HP:0011867)1.62161731
192Abnormality of renal excretion (HP:0011036)1.61442320
193Poikilocytosis (HP:0004447)1.60023784

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK198.58174627
2FRK5.80775859
3SIK34.33632687
4WNK43.75241184
5SIK23.32071247
6MAP3K103.01752274
7SIK12.99132721
8FGFR42.72463788
9NTRK32.56124146
10MAP4K22.36169861
11FGFR32.32292672
12GRK12.16433213
13INSRR2.06201338
14EPHA32.04918518
15NUAK11.80623347
16CDK121.80202684
17BRD41.79428379
18EPHA41.72417035
19ZAK1.71408513
20EEF2K1.69768109
21PNCK1.67489187
22MARK31.65539876
23BRSK21.65004416
24ALK1.64846438
25MARK11.63638083
26ADRBK21.58269926
27MAP2K61.45189846
28WNK31.45106841
29NTRK11.43802498
30ACVR1B1.41447143
31PIK3CA1.40098000
32STK391.36300448
33MAPKAPK31.35131871
34MAP3K41.31981870
35EPHA21.29706631
36MAP2K41.26771043
37PINK11.22268257
38WNK11.22151289
39PRKD31.21432074
40MAP3K71.18137718
41MUSK1.14488501
42CSNK1A1L1.13780761
43PRKAA21.13428123
44NTRK21.11412384
45MAP3K21.11089093
46TAF11.06654152
47MAPK131.06177770
48SGK31.05949197
49MET1.00597961
50MAP2K20.98864220
51NME10.98777978
52RPS6KB20.96786924
53NEK20.95155413
54MKNK20.94154778
55NLK0.93911638
56CASK0.93271344
57SGK20.92518148
58PAK60.90919384
59MAPKAPK50.90256036
60SGK2230.89331199
61SGK4940.89331199
62MARK20.88883717
63TAOK30.88660338
64PRKD20.87574418
65DAPK20.85993355
66PAK30.84972067
67LATS10.84140966
68MAPK110.83862263
69DYRK1A0.81437354
70CSNK1G30.80820819
71CAMK1G0.80696277
72IRAK10.76413068
73CSNK1G20.75560362
74CSNK1D0.74668078
75FGFR20.72833440
76AKT30.72709180
77LATS20.71283608
78KSR10.70637431
79TNIK0.70393937
80PRKAA10.70005509
81STK30.67602348
82ICK0.67231521
83CDK50.66838200
84OXSR10.66761881
85ITK0.66172865
86PRPF4B0.65944828
87PKN10.65265990
88UHMK10.65055721
89MAPK100.64043311
90MAP2K70.63615959
91STK38L0.62990297
92BCR0.62676831
93CAMK1D0.62478417
94SGK10.61625133
95WEE10.60563447
96MINK10.58464045
97CDC42BPA0.57779624
98CDK11A0.57208849
99TYRO30.54432962
100TNK20.53593890
101CSNK1E0.52656036
102PTK60.52259277
103MTOR0.52243470
104CHUK0.51994624
105MAP3K90.50348389
106GSK3B0.50289257
107EPHB20.50256546
108PHKG10.50198265
109PHKG20.50198265
110PLK20.50092203
111SMG10.49823223
112IKBKB0.48909342
113ATR0.48363595
114PRKCI0.47722015
115MAP2K10.47607831
116CSNK1G10.46893093
117CSNK1A10.45555575
118FGR0.45508437
119CDK40.45336230
120BMPR1B0.45264459
121MAPK80.44450587
122ATM0.44097367
123MAPK90.43737579
124PRKCG0.43380280
125PRKCH0.41831663
126ERBB20.40263755
127BMX0.39948762
128BRSK10.39583164
129CAMK40.39269826
130MAPK140.38784128
131HIPK20.38518759
132AKT10.38496327
133STK380.37122097
134PRKCZ0.36549489
135TSSK60.36333162
136RPS6KA60.36257550
137TLK10.35732695
138MAPK120.35589853
139RPS6KA20.35526580
140DYRK20.35291142
141MAP3K140.35174017
142TRIB30.35160065
143CHEK20.34748326
144PASK0.34435377
145CDK20.34378543
146CDC70.33273591
147PRKDC0.32666855
148RPS6KA30.32392098
149INSR0.31381491
150NEK60.31217177
151JAK30.31039907
152STK110.30401780
153PRKCE0.30055350
154RPS6KB10.29814135
155CDK10.28992064
156ERBB30.28614761
157CAMK2A0.28413624
158FGFR10.28357028

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.97654883
2Synaptic vesicle cycle_Homo sapiens_hsa047212.90227992
3ABC transporters_Homo sapiens_hsa020102.51232715
4One carbon pool by folate_Homo sapiens_hsa006702.35417275
5Insulin secretion_Homo sapiens_hsa049112.33980843
6Nitrogen metabolism_Homo sapiens_hsa009102.32788669
7Selenocompound metabolism_Homo sapiens_hsa004502.28863144
8African trypanosomiasis_Homo sapiens_hsa051432.28548655
9Type II diabetes mellitus_Homo sapiens_hsa049302.24118055
10Butanoate metabolism_Homo sapiens_hsa006502.20825281
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15530347
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.09896607
13Complement and coagulation cascades_Homo sapiens_hsa046102.08685590
14GABAergic synapse_Homo sapiens_hsa047272.08019536
15Vitamin digestion and absorption_Homo sapiens_hsa049772.04816721
16Circadian entrainment_Homo sapiens_hsa047132.01964706
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.93963112
18Morphine addiction_Homo sapiens_hsa050321.93145335
19Glutamatergic synapse_Homo sapiens_hsa047241.92732713
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91713258
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.90653314
22Fat digestion and absorption_Homo sapiens_hsa049751.85306764
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.83574274
24Amphetamine addiction_Homo sapiens_hsa050311.79092369
25Tryptophan metabolism_Homo sapiens_hsa003801.78822180
26Long-term potentiation_Homo sapiens_hsa047201.78595771
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.78552653
28Linoleic acid metabolism_Homo sapiens_hsa005911.77758528
29Cholinergic synapse_Homo sapiens_hsa047251.72061849
30Olfactory transduction_Homo sapiens_hsa047401.70326681
31Cocaine addiction_Homo sapiens_hsa050301.68219245
32Serotonergic synapse_Homo sapiens_hsa047261.66544261
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.66219818
34Axon guidance_Homo sapiens_hsa043601.66200375
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66141443
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63892163
37Dopaminergic synapse_Homo sapiens_hsa047281.62435702
38Ether lipid metabolism_Homo sapiens_hsa005651.60435023
39Taste transduction_Homo sapiens_hsa047421.60070581
40Fatty acid degradation_Homo sapiens_hsa000711.58345979
41Histidine metabolism_Homo sapiens_hsa003401.55230144
42Salivary secretion_Homo sapiens_hsa049701.51556581
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.49778853
44Caffeine metabolism_Homo sapiens_hsa002321.45464730
45Long-term depression_Homo sapiens_hsa047301.45175181
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.45039279
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.44351304
48Pentose and glucuronate interconversions_Homo sapiens_hsa000401.44255248
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40670262
50Mineral absorption_Homo sapiens_hsa049781.39352584
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.36971159
52Dorso-ventral axis formation_Homo sapiens_hsa043201.36463038
53Fatty acid metabolism_Homo sapiens_hsa012121.35664233
54Type I diabetes mellitus_Homo sapiens_hsa049401.34267778
55Primary bile acid biosynthesis_Homo sapiens_hsa001201.32774626
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32103682
57Renin secretion_Homo sapiens_hsa049241.31565289
58ErbB signaling pathway_Homo sapiens_hsa040121.31403565
59Calcium signaling pathway_Homo sapiens_hsa040201.29167030
60Chemical carcinogenesis_Homo sapiens_hsa052041.27597157
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26978927
62Propanoate metabolism_Homo sapiens_hsa006401.26655454
63Retinol metabolism_Homo sapiens_hsa008301.25764740
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24693372
65Steroid biosynthesis_Homo sapiens_hsa001001.23845280
66Fanconi anemia pathway_Homo sapiens_hsa034601.22572965
67Phototransduction_Homo sapiens_hsa047441.21033194
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20606175
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16048814
70Fatty acid biosynthesis_Homo sapiens_hsa000611.15984898
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15469873
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14916070
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14645629
74Homologous recombination_Homo sapiens_hsa034401.14524468
75Peroxisome_Homo sapiens_hsa041461.13458065
76MAPK signaling pathway_Homo sapiens_hsa040101.10226452
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09808958
78Renin-angiotensin system_Homo sapiens_hsa046141.09132727
79Gastric acid secretion_Homo sapiens_hsa049711.08815805
80Glycerolipid metabolism_Homo sapiens_hsa005611.08473617
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07630504
82Renal cell carcinoma_Homo sapiens_hsa052111.07129861
83Vitamin B6 metabolism_Homo sapiens_hsa007501.07079703
84Collecting duct acid secretion_Homo sapiens_hsa049661.06995527
85Glycerophospholipid metabolism_Homo sapiens_hsa005641.02533082
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00681596
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00507526
88Oxytocin signaling pathway_Homo sapiens_hsa049211.00262457
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99754394
90Arginine and proline metabolism_Homo sapiens_hsa003300.96177287
91Vibrio cholerae infection_Homo sapiens_hsa051100.95936326
92Basal transcription factors_Homo sapiens_hsa030220.95524771
93beta-Alanine metabolism_Homo sapiens_hsa004100.93323493
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92801771
95Estrogen signaling pathway_Homo sapiens_hsa049150.91246288
96Glioma_Homo sapiens_hsa052140.90026385
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89762049
98Wnt signaling pathway_Homo sapiens_hsa043100.89073126
99Ovarian steroidogenesis_Homo sapiens_hsa049130.87910986
100Bile secretion_Homo sapiens_hsa049760.87694641
101GnRH signaling pathway_Homo sapiens_hsa049120.87412466
102RNA polymerase_Homo sapiens_hsa030200.87240109
103PPAR signaling pathway_Homo sapiens_hsa033200.84921123
104Gap junction_Homo sapiens_hsa045400.84335518
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83781710
106cAMP signaling pathway_Homo sapiens_hsa040240.81826430
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80874494
108Prolactin signaling pathway_Homo sapiens_hsa049170.79608428
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79533522
110Hedgehog signaling pathway_Homo sapiens_hsa043400.78799863
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77387168
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75614588
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.74874464
114Melanogenesis_Homo sapiens_hsa049160.74623652
115Lysine degradation_Homo sapiens_hsa003100.74541428
116Glucagon signaling pathway_Homo sapiens_hsa049220.74149846
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73352257
118Ras signaling pathway_Homo sapiens_hsa040140.72491710
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.69640340
120Circadian rhythm_Homo sapiens_hsa047100.68513451
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67359190
122Starch and sucrose metabolism_Homo sapiens_hsa005000.67260668
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66820216
124Sphingolipid metabolism_Homo sapiens_hsa006000.66057047
125Sulfur relay system_Homo sapiens_hsa041220.65147954
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64656204
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64042467
128T cell receptor signaling pathway_Homo sapiens_hsa046600.63053385
129Tyrosine metabolism_Homo sapiens_hsa003500.61003262
130Choline metabolism in cancer_Homo sapiens_hsa052310.60281135
131Metabolic pathways_Homo sapiens_hsa011000.60159465
132Melanoma_Homo sapiens_hsa052180.59733250
133Inositol phosphate metabolism_Homo sapiens_hsa005620.59444127
134mTOR signaling pathway_Homo sapiens_hsa041500.58847207
135Thyroid hormone synthesis_Homo sapiens_hsa049180.58148377
136MicroRNAs in cancer_Homo sapiens_hsa052060.56647102
137Asthma_Homo sapiens_hsa053100.56630953
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56281184
139Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56210955
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55943195
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55676211
142Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53367272
143Rap1 signaling pathway_Homo sapiens_hsa040150.52455338
144Arginine biosynthesis_Homo sapiens_hsa002200.50940817
145Dilated cardiomyopathy_Homo sapiens_hsa054140.50229608
146Rheumatoid arthritis_Homo sapiens_hsa053230.50201074
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50139931
148Vascular smooth muscle contraction_Homo sapiens_hsa042700.50131885
149Pancreatic secretion_Homo sapiens_hsa049720.50086527
150FoxO signaling pathway_Homo sapiens_hsa040680.48101505
151Glycosaminoglycan degradation_Homo sapiens_hsa005310.47346595
152Regulation of autophagy_Homo sapiens_hsa041400.46638119
153Neurotrophin signaling pathway_Homo sapiens_hsa047220.46337678
154Basal cell carcinoma_Homo sapiens_hsa052170.45590266
155Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45463414
156Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44741052
157mRNA surveillance pathway_Homo sapiens_hsa030150.44561933
158Arachidonic acid metabolism_Homo sapiens_hsa005900.44309037
159Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43865382
160Allograft rejection_Homo sapiens_hsa053300.42977069
161Phenylalanine metabolism_Homo sapiens_hsa003600.41506458
162Prion diseases_Homo sapiens_hsa050200.41373303
163RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41174236
164RNA degradation_Homo sapiens_hsa030180.40710540
165Non-small cell lung cancer_Homo sapiens_hsa052230.40292155
166Chronic myeloid leukemia_Homo sapiens_hsa052200.39614365
167Insulin resistance_Homo sapiens_hsa049310.38587267
168N-Glycan biosynthesis_Homo sapiens_hsa005100.38196368
169Drug metabolism - other enzymes_Homo sapiens_hsa009830.38134004
170Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37681401
171Hippo signaling pathway_Homo sapiens_hsa043900.37089057
172Pyruvate metabolism_Homo sapiens_hsa006200.35805169

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