WDR5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene encodes a protein containing several WD40 repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, including a trp-asp at the C-terminal end. The encoded protein may mediate protein-protein interactions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.40535737
2cilium or flagellum-dependent cell motility (GO:0001539)6.24236725
3epithelial cilium movement (GO:0003351)6.21999781
4ribosomal small subunit assembly (GO:0000028)6.05167570
5cilium movement (GO:0003341)5.87324184
6axonemal dynein complex assembly (GO:0070286)5.55332807
7antigen processing and presentation via MHC class Ib (GO:0002475)5.37410272
8positive regulation of gamma-delta T cell activation (GO:0046645)5.32938950
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.22971464
10viral transcription (GO:0019083)5.13983293
11translational termination (GO:0006415)4.67909156
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.63156938
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.63156938
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.58550850
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.56505785
16antigen processing and presentation of endogenous antigen (GO:0019883)4.54126140
17cotranslational protein targeting to membrane (GO:0006613)4.52703183
18axoneme assembly (GO:0035082)4.50317673
19telomere maintenance via semi-conservative replication (GO:0032201)4.49656023
20protein targeting to ER (GO:0045047)4.43912795
21telomere maintenance via recombination (GO:0000722)4.39424773
22neural tube formation (GO:0001841)4.36663401
23B cell receptor signaling pathway (GO:0050853)4.31701710
24regulation of cilium movement (GO:0003352)4.31396717
25protein localization to endoplasmic reticulum (GO:0070972)4.27720111
26viral mRNA export from host cell nucleus (GO:0046784)4.25442402
27establishment of protein localization to endoplasmic reticulum (GO:0072599)4.23708848
28mitotic recombination (GO:0006312)4.20412118
29cilium organization (GO:0044782)4.19598898
30regulation of B cell receptor signaling pathway (GO:0050855)4.18133481
31amino acid salvage (GO:0043102)4.16993923
32L-methionine salvage (GO:0071267)4.16993923
33L-methionine biosynthetic process (GO:0071265)4.16993923
34L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.15243667
35motile cilium assembly (GO:0044458)4.10085561
36cilium assembly (GO:0042384)4.08733130
37positive regulation of B cell differentiation (GO:0045579)4.07816953
38respiratory chain complex IV assembly (GO:0008535)4.07458220
39deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.05176839
40nonmotile primary cilium assembly (GO:0035058)4.01800928
41regulation of gamma-delta T cell differentiation (GO:0045586)4.01062925
42photoreceptor cell maintenance (GO:0045494)3.94695721
43detection of light stimulus involved in visual perception (GO:0050908)3.89704106
44detection of light stimulus involved in sensory perception (GO:0050962)3.89704106
45translational elongation (GO:0006414)3.88588296
46pyrimidine dimer repair (GO:0006290)3.88320542
47cilium morphogenesis (GO:0060271)3.87674402
48N-glycan processing (GO:0006491)3.84111671
49regulation of gamma-delta T cell activation (GO:0046643)3.83716355
50detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.81766903
51viral life cycle (GO:0019058)3.69004108
52S-adenosylmethionine metabolic process (GO:0046500)3.65480507
53platelet dense granule organization (GO:0060155)3.64973897
54positive regulation of DNA biosynthetic process (GO:2000573)3.62345167
55intraciliary transport (GO:0042073)3.61536543
56pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.60723810
57nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.60381467
58DNA strand elongation involved in DNA replication (GO:0006271)3.58472314
59cellular protein complex disassembly (GO:0043624)3.56241829
60preassembly of GPI anchor in ER membrane (GO:0016254)3.54387235
61endosome to pigment granule transport (GO:0043485)3.53683202
62endosome to melanosome transport (GO:0035646)3.53683202
63regulation of B cell differentiation (GO:0045577)3.44358934
64DNA deamination (GO:0045006)3.43976251
65DNA strand elongation (GO:0022616)3.42862932
66establishment of protein localization to Golgi (GO:0072600)3.40833508
67negative regulation of mast cell activation (GO:0033004)3.38416926
68nucleotide-excision repair, DNA gap filling (GO:0006297)3.35930405
69positive regulation of granulocyte differentiation (GO:0030854)3.30482356
70ribosomal small subunit biogenesis (GO:0042274)3.28020030
71protein complex disassembly (GO:0043241)3.26410660
72regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.22531121
73response to UV-B (GO:0010224)3.21593392
74regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.18622898
75base-excision repair, AP site formation (GO:0006285)3.15177795
76prenylation (GO:0097354)3.14338359
77protein prenylation (GO:0018342)3.14338359
78metallo-sulfur cluster assembly (GO:0031163)3.12438667
79iron-sulfur cluster assembly (GO:0016226)3.12438667
80pentose-phosphate shunt (GO:0006098)3.10111704
81reciprocal DNA recombination (GO:0035825)3.09681638
82reciprocal meiotic recombination (GO:0007131)3.09681638
83macromolecular complex disassembly (GO:0032984)3.08326188
84cytochrome complex assembly (GO:0017004)3.08163819
85mast cell activation (GO:0045576)3.07594805
86definitive hemopoiesis (GO:0060216)3.06748405
87methionine biosynthetic process (GO:0009086)3.06728746
88indolalkylamine metabolic process (GO:0006586)3.06515024
89regulation of sarcomere organization (GO:0060297)3.05365852
90response to interferon-beta (GO:0035456)3.02700625
91ubiquinone biosynthetic process (GO:0006744)3.00453878
92cellular component assembly involved in morphogenesis (GO:0010927)2.98394298
93anterograde synaptic vesicle transport (GO:0048490)2.98175182
94translational initiation (GO:0006413)2.97206188
95megakaryocyte development (GO:0035855)2.97173729
96response to nitrosative stress (GO:0051409)2.96890207
97tryptophan metabolic process (GO:0006568)2.96881952
98kynurenine metabolic process (GO:0070189)2.96670161
99T cell homeostasis (GO:0043029)2.96118958
100mast cell activation involved in immune response (GO:0002279)2.95137795
101mast cell degranulation (GO:0043303)2.95137795
102indole-containing compound catabolic process (GO:0042436)2.94918435
103indolalkylamine catabolic process (GO:0046218)2.94918435
104tryptophan catabolic process (GO:0006569)2.94918435
105protein targeting to membrane (GO:0006612)2.94794456
106regulation of T cell receptor signaling pathway (GO:0050856)2.93986056
107cellular response to fluid shear stress (GO:0071498)2.92559438
108protein targeting to Golgi (GO:0000042)2.92497199
109positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.92452869
110negative regulation of erythrocyte differentiation (GO:0045647)2.91777819
111pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.90751052
112signal peptide processing (GO:0006465)2.90013373
113reflex (GO:0060004)2.87202532
114regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.86758321
115monoubiquitinated protein deubiquitination (GO:0035520)2.86703470
116protein localization to cilium (GO:0061512)2.86370488
117left/right axis specification (GO:0070986)2.85694912
118regulation of memory T cell differentiation (GO:0043380)2.84216672
119protein targeting to vacuole (GO:0006623)2.82474268
120protein targeting to lysosome (GO:0006622)2.82474268
121establishment of protein localization to vacuole (GO:0072666)2.82474268
122negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.82026092
123purine-containing compound salvage (GO:0043101)2.81926596
124leukocyte homeostasis (GO:0001776)2.81745394
125lymphoid progenitor cell differentiation (GO:0002320)2.79579537
126pyrimidine nucleotide catabolic process (GO:0006244)2.77273613
127RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.76656719
128GPI anchor metabolic process (GO:0006505)2.76192879
129negative thymic T cell selection (GO:0045060)2.75442388
130post-embryonic morphogenesis (GO:0009886)2.74934922
131regulation of relaxation of muscle (GO:1901077)2.74408030
132nuclear-transcribed mRNA catabolic process (GO:0000956)2.74239919
133ubiquinone metabolic process (GO:0006743)2.73210740
134protein K11-linked deubiquitination (GO:0035871)2.72926504
135translesion synthesis (GO:0019985)2.72883719
136purinergic nucleotide receptor signaling pathway (GO:0035590)2.72246773
137antigen receptor-mediated signaling pathway (GO:0050851)2.72135710
138fucose catabolic process (GO:0019317)2.71862741
139L-fucose metabolic process (GO:0042354)2.71862741
140L-fucose catabolic process (GO:0042355)2.71862741
141telomere maintenance via telomere lengthening (GO:0010833)2.70732988
142regulation of T cell tolerance induction (GO:0002664)2.70631811
143ventricular system development (GO:0021591)2.70379167
144DNA integration (GO:0015074)2.68116269
145DNA demethylation (GO:0080111)2.67783077
146secretory granule organization (GO:0033363)2.67286687
147chaperone mediated protein folding requiring cofactor (GO:0051085)2.66772145
148inositol phosphate catabolic process (GO:0071545)2.66158558
149C-terminal protein amino acid modification (GO:0018410)2.65176438
150recombinational repair (GO:0000725)2.63937415
151cellular response to zinc ion (GO:0071294)2.63211106
152phosphatidylinositol acyl-chain remodeling (GO:0036149)2.63206557
153double-strand break repair via homologous recombination (GO:0000724)2.63078634
154centriole replication (GO:0007099)2.62977732
155negative T cell selection (GO:0043383)2.62927093
156programmed necrotic cell death (GO:0097300)2.62678943
157positive regulation of oligodendrocyte differentiation (GO:0048714)2.62085220
158C-terminal protein lipidation (GO:0006501)2.61971910
159regulation of centriole replication (GO:0046599)2.61961356
160positive regulation of defense response to virus by host (GO:0002230)2.61598025
161lymphocyte homeostasis (GO:0002260)2.60573999
162positive regulation of prostaglandin secretion (GO:0032308)2.59424129
163positive regulation of developmental pigmentation (GO:0048087)2.59079571
164xenobiotic catabolic process (GO:0042178)2.59062435
165phosphorylated carbohydrate dephosphorylation (GO:0046838)2.57998669
166inositol phosphate dephosphorylation (GO:0046855)2.57998669
167retrograde transport, vesicle recycling within Golgi (GO:0000301)2.57690678
168peptidyl-histidine modification (GO:0018202)2.57678391
169negative regulation of phagocytosis (GO:0050765)2.57139832
170mRNA catabolic process (GO:0006402)2.56960604
171polyol catabolic process (GO:0046174)2.56572119
172intracellular transport of virus (GO:0075733)2.55922439
173multi-organism transport (GO:0044766)2.55922439
174multi-organism localization (GO:1902579)2.55922439
175multi-organism intracellular transport (GO:1902583)2.55922439
176transport of virus (GO:0046794)2.55922439
177fucosylation (GO:0036065)2.52546852
178negative regulation of bone mineralization (GO:0030502)2.52454993
179replication fork processing (GO:0031297)2.52324318
180regulation of meiosis I (GO:0060631)2.49422951
181methionine metabolic process (GO:0006555)2.49406552
182cell projection assembly (GO:0030031)2.47864203
183benzene-containing compound metabolic process (GO:0042537)2.46989909
184cellular ketone body metabolic process (GO:0046950)2.45986124
185quinone biosynthetic process (GO:1901663)2.44083962
186oxidative demethylation (GO:0070989)2.43594518
187positive regulation of protein homodimerization activity (GO:0090073)2.42664826
188mannosylation (GO:0097502)2.41572099
189protein import into peroxisome matrix (GO:0016558)2.40976127
190GPI anchor biosynthetic process (GO:0006506)2.40371685
191cellular response to ethanol (GO:0071361)2.40178670
192protein localization to Golgi apparatus (GO:0034067)2.39146473

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.72462027
2ELF1_17652178_ChIP-ChIP_JURKAT_Human5.21828400
3SCL_19346495_ChIP-Seq_HPC-7_Human4.39361925
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.03480102
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.54543438
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.53621940
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.34751048
8GATA1_22025678_ChIP-Seq_K562_Human3.28751025
9IGF1R_20145208_ChIP-Seq_DFB_Human3.19051196
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.18906552
11ZNF274_21170338_ChIP-Seq_K562_Hela3.05895945
12POU3F2_20337985_ChIP-ChIP_501MEL_Human3.04805287
13SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.95104299
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.89937256
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.65307476
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64503584
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.64395138
18GBX2_23144817_ChIP-Seq_PC3_Human2.51692306
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.51121763
20* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.50253656
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.49656340
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.48413760
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.47596531
24TAF15_26573619_Chip-Seq_HEK293_Human2.46301907
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.44879132
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.39872000
27VDR_22108803_ChIP-Seq_LS180_Human2.35859259
28EWS_26573619_Chip-Seq_HEK293_Human2.35057132
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.34342667
30FUS_26573619_Chip-Seq_HEK293_Human2.34324468
31SALL1_21062744_ChIP-ChIP_HESCs_Human2.33368323
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.33158484
33VDR_21846776_ChIP-Seq_THP-1_Human2.33058677
34HOXB4_20404135_ChIP-ChIP_EML_Mouse2.29559331
35ER_23166858_ChIP-Seq_MCF-7_Human2.27480116
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.26260962
37E2F4_17652178_ChIP-ChIP_JURKAT_Human2.24948097
38SPI1_23547873_ChIP-Seq_NB4_Human2.09535876
39ERG_20887958_ChIP-Seq_HPC-7_Mouse2.05787490
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05153839
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.01829827
42MYC_22102868_ChIP-Seq_BL_Human1.97412064
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.93845365
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93292209
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91858938
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.91137027
47CIITA_25753668_ChIP-Seq_RAJI_Human1.90476739
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.89794348
49IRF8_21731497_ChIP-ChIP_J774_Mouse1.89264463
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88057817
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87174348
52MYB_26560356_Chip-Seq_TH2_Human1.86800454
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86588900
54KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.82352112
55P300_19829295_ChIP-Seq_ESCs_Human1.80434534
56VDR_23849224_ChIP-Seq_CD4+_Human1.78848276
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76421890
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.75811934
59UTX_26944678_Chip-Seq_JUKART_Human1.74470443
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.71434072
61CBP_20019798_ChIP-Seq_JUKART_Human1.70605875
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.70605875
63* GABP_17652178_ChIP-ChIP_JURKAT_Human1.68334203
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.67659243
65* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.67050361
66FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.65445472
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.65138474
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.64442634
69SMAD4_21799915_ChIP-Seq_A2780_Human1.63870929
70IRF1_19129219_ChIP-ChIP_H3396_Human1.63124144
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62039695
72MYB_26560356_Chip-Seq_TH1_Human1.59524919
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58834879
74FOXP3_21729870_ChIP-Seq_TREG_Human1.58554736
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.58461023
76STAT3_23295773_ChIP-Seq_U87_Human1.57902532
77* ETS1_20019798_ChIP-Seq_JURKAT_Human1.55135240
78GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.55015302
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53399703
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53136040
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52485482
82RUNX_20019798_ChIP-Seq_JUKART_Human1.52005824
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50696863
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50591775
85XRN2_22483619_ChIP-Seq_HELA_Human1.50247387
86VDR_24763502_ChIP-Seq_THP-1_Human1.49825190
87LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49678719
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.48840861
89GATA1_22383799_ChIP-Seq_G1ME_Mouse1.48116565
90TP53_22573176_ChIP-Seq_HFKS_Human1.45581073
91JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44878366
92* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44017948
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42834584
94E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42680487
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.41813123
96MYC_18555785_ChIP-Seq_MESCs_Mouse1.41083223
97MAF_26560356_Chip-Seq_TH1_Human1.40946250
98RUNX1_22412390_ChIP-Seq_EML_Mouse1.39250749
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38670689
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38095488
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.37404366
102CRX_20693478_ChIP-Seq_RETINA_Mouse1.36846849
103PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35597762
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34990475
105CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.34920890
106FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34259478
107TCF4_23295773_ChIP-Seq_U87_Human1.33677329
108MYC_18358816_ChIP-ChIP_MESCs_Mouse1.33384900
109E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32767599
110GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32252673
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31430513
112CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31075126
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30760874
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29509201
115SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28978655
116PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28763181
117PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27385711
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27318441
119TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26850724
120P53_22387025_ChIP-Seq_ESCs_Mouse1.25901725
121AR_25329375_ChIP-Seq_VCAP_Human1.25874750
122FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24666907
123SMAD_19615063_ChIP-ChIP_OVARY_Human1.23243174
124TCF4_22108803_ChIP-Seq_LS180_Human1.22691457
125ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21638907
126BCAT_22108803_ChIP-Seq_LS180_Human1.21542133
127THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21474689
128CDX2_22108803_ChIP-Seq_LS180_Human1.21369677
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21361955
130SMAD3_21741376_ChIP-Seq_EPCs_Human1.20471800
131E2F1_18555785_Chip-Seq_ESCs_Mouse1.20347068
132KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19427425
133* RUNX2_22187159_ChIP-Seq_PCA_Human1.19143164
134RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.18857685
135GATA3_27048872_Chip-Seq_THYMUS_Human1.18637603
136SPI1_23127762_ChIP-Seq_K562_Human1.18526340
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18270147
138IRF8_27001747_Chip-Seq_BMDM_Mouse1.18212020
139FLI1_21867929_ChIP-Seq_TH2_Mouse1.16584139
140GATA3_26560356_Chip-Seq_TH2_Human1.15502812
141FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15127625
142SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14602317
143PRDM14_20953172_ChIP-Seq_ESCs_Human1.13671569
144EGR1_19374776_ChIP-ChIP_THP-1_Human1.13232467
145MYC_18940864_ChIP-ChIP_HL60_Human1.12580444
146* AR_20517297_ChIP-Seq_VCAP_Human1.12499225
147TP63_19390658_ChIP-ChIP_HaCaT_Human1.12343893
148STAT3_18555785_Chip-Seq_ESCs_Mouse1.12297804
149SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11439818
150FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11028356
151FOXA1_25329375_ChIP-Seq_VCAP_Human1.11028356
152FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10238211
153NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10222749
154OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10118886
155GABP_19822575_ChIP-Seq_HepG2_Human1.09716057
156TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09203543
157P300_18555785_Chip-Seq_ESCs_Mouse1.09199484
158MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08275055
159EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08239522
160EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07973184
161GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06974737
162STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.06033879
163OCT4_18555785_Chip-Seq_ESCs_Mouse1.05701738
164CMYC_18555785_Chip-Seq_ESCs_Mouse1.05619815
165SOX2_19829295_ChIP-Seq_ESCs_Human1.04563352
166NANOG_19829295_ChIP-Seq_ESCs_Human1.04563352
167* ELK1_19687146_ChIP-ChIP_HELA_Human1.03161028
168POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02501490
169TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02501490
170CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02040386
171GATA1_19941827_ChIP-Seq_MEL_Mouse1.01955232
172E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01913290
173* DCP1A_22483619_ChIP-Seq_HELA_Human1.01730544
174* MAF_26560356_Chip-Seq_TH2_Human0.99814371
175TAL1_26923725_Chip-Seq_HPCs_Mouse0.97339214
176FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97138691
177CTCF_18555785_ChIP-Seq_MESCs_Mouse0.94546084
178TCF7_22412390_ChIP-Seq_EML_Mouse0.92412862
179PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92283974
180PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91228902
181MYC_19030024_ChIP-ChIP_MESCs_Mouse0.89894075
182TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88752376
183* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87470155
184ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87395163

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.92005524
2MP0001835_abnormal_antigen_presentation3.78112082
3MP0006054_spinal_hemorrhage3.56018499
4MP0000685_abnormal_immune_system3.34639609
5MP0003195_calcinosis3.25751142
6MP0005671_abnormal_response_to3.06385132
7MP0003183_abnormal_peptide_metabolism2.68351842
8MP0005464_abnormal_platelet_physiology2.66839801
9MP0001800_abnormal_humoral_immune2.57179358
10MP0003763_abnormal_thymus_physiology2.49031810
11MP0002396_abnormal_hematopoietic_system2.48902984
12MP0002398_abnormal_bone_marrow2.40316401
13MP0000015_abnormal_ear_pigmentation2.33922560
14MP0002653_abnormal_ependyma_morphology2.33700619
15MP0000465_gastrointestinal_hemorrhage2.29409899
16MP0003011_delayed_dark_adaptation2.28041173
17MP0002420_abnormal_adaptive_immunity2.26360889
18MP0008877_abnormal_DNA_methylation2.25398567
19MP0002102_abnormal_ear_morphology2.24216697
20MP0009785_altered_susceptibility_to2.23772852
21MP0009379_abnormal_foot_pigmentation2.22251772
22MP0001819_abnormal_immune_cell2.18529131
23MP0002166_altered_tumor_susceptibility2.17070866
24MP0002452_abnormal_antigen_presenting2.14657778
25MP0000427_abnormal_hair_cycle2.12251570
26MP0005000_abnormal_immune_tolerance2.10453901
27MP0002723_abnormal_immune_serum2.09820581
28MP0006292_abnormal_olfactory_placode2.09417309
29MP0001968_abnormal_touch/_nociception2.08700268
30MP0005551_abnormal_eye_electrophysiolog2.08478847
31MP0005171_absent_coat_pigmentation2.03251889
32MP0001984_abnormal_olfaction2.01978137
33MP0004043_abnormal_pH_regulation2.00985463
34MP0004808_abnormal_hematopoietic_stem1.99567019
35MP0000716_abnormal_immune_system1.98693916
36MP0005025_abnormal_response_to1.92964293
37MP0001790_abnormal_immune_system1.92305924
38MP0005387_immune_system_phenotype1.92305924
39MP0005174_abnormal_tail_pigmentation1.91129985
40MP0003436_decreased_susceptibility_to1.90604447
41MP0000689_abnormal_spleen_morphology1.88402560
42MP0004885_abnormal_endolymph1.87749010
43MP0008875_abnormal_xenobiotic_pharmacok1.87212160
44MP0002095_abnormal_skin_pigmentation1.86801275
45MP0002736_abnormal_nociception_after1.85897562
46MP0000383_abnormal_hair_follicle1.84736198
47MP0002938_white_spotting1.83943629
48MP0001853_heart_inflammation1.81909993
49MP0002148_abnormal_hypersensitivity_rea1.81460183
50MP0002009_preneoplasia1.81404068
51MP0002429_abnormal_blood_cell1.79488573
52MP0000372_irregular_coat_pigmentation1.73492045
53MP0001986_abnormal_taste_sensitivity1.71774101
54MP0005397_hematopoietic_system_phenotyp1.65211806
55MP0001545_abnormal_hematopoietic_system1.65211806
56MP0003172_abnormal_lysosome_physiology1.65157110
57MP0002722_abnormal_immune_system1.64472527
58MP0008058_abnormal_DNA_repair1.60874709
59MP0003943_abnormal_hepatobiliary_system1.59066547
60MP0005409_darkened_coat_color1.55380820
61MP0006072_abnormal_retinal_apoptosis1.53458793
62MP0002419_abnormal_innate_immunity1.52281359
63MP0005220_abnormal_exocrine_pancreas1.50861459
64MP0001873_stomach_inflammation1.40411101
65MP0002876_abnormal_thyroid_physiology1.39946761
66MP0002933_joint_inflammation1.38294359
67MP0001764_abnormal_homeostasis1.34870731
68MP0010386_abnormal_urinary_bladder1.33597348
69MP0000703_abnormal_thymus_morphology1.31055068
70MP0002909_abnormal_adrenal_gland1.28432747
71MP0001324_abnormal_eye_pigmentation1.24464486
72MP0005084_abnormal_gallbladder_morpholo1.24176764
73MP0009780_abnormal_chondrocyte_physiolo1.23942847
74MP0005075_abnormal_melanosome_morpholog1.23518436
75MP0010678_abnormal_skin_adnexa1.21565572
76MP0005085_abnormal_gallbladder_physiolo1.21239074
77MP0005379_endocrine/exocrine_gland_phen1.20996284
78MP0001501_abnormal_sleep_pattern1.20271634
79MP0001919_abnormal_reproductive_system1.19459104
80MP0003724_increased_susceptibility_to1.17219136
81MP0001845_abnormal_inflammatory_respons1.17036970
82MP0002282_abnormal_trachea_morphology1.16479517
83MP0001346_abnormal_lacrimal_gland1.15704641
84MP0008789_abnormal_olfactory_epithelium1.15534110
85MP0009333_abnormal_splenocyte_physiolog1.14658783
86MP0000647_abnormal_sebaceous_gland1.14476761
87MP0003950_abnormal_plasma_membrane1.13842831
88MP0000858_altered_metastatic_potential1.13510406
89MP0002006_tumorigenesis1.12820801
90MP0002751_abnormal_autonomic_nervous1.12775408
91MP0005248_abnormal_Harderian_gland1.11440197
92MP0000371_diluted_coat_color1.10572674
93MP0004147_increased_porphyrin_level1.09910121
94MP0002019_abnormal_tumor_incidence1.09104881
95MP0003866_abnormal_defecation1.08105100
96MP0002234_abnormal_pharynx_morphology1.07520689
97MP0008872_abnormal_physiological_respon1.06923555
98MP0002138_abnormal_hepatobiliary_system1.06827309
99MP0003693_abnormal_embryo_hatching1.06567719
100MP0010155_abnormal_intestine_physiology1.04701045
101MP0005391_vision/eye_phenotype1.04274809
102MP0004484_altered_response_of1.03274763
103MP0009764_decreased_sensitivity_to1.02418709
104MP0001188_hyperpigmentation1.02176208
105MP0005408_hypopigmentation1.01438811
106MP0005645_abnormal_hypothalamus_physiol1.01135276
107MP0001958_emphysema0.99852865
108MP0005389_reproductive_system_phenotype0.99461185
109MP0008057_abnormal_DNA_replication0.99331655
110MP0004133_heterotaxia0.98922934
111MP0000613_abnormal_salivary_gland0.97624322
112MP0006276_abnormal_autonomic_nervous0.97230046
113MP0005253_abnormal_eye_physiology0.97226872
114MP0008260_abnormal_autophagy0.94272538
115MP0002638_abnormal_pupillary_reflex0.92248607
116MP0001929_abnormal_gametogenesis0.91318921
117MP0005365_abnormal_bile_salt0.90124035
118MP0000490_abnormal_crypts_of0.89906910
119MP0003787_abnormal_imprinting0.89625167
120MP0008007_abnormal_cellular_replicative0.89304553
121MP0003279_aneurysm0.88315063
122MP0002405_respiratory_system_inflammati0.85676153
123MP0008469_abnormal_protein_level0.84977937
124MP0001186_pigmentation_phenotype0.84707377
125MP0003252_abnormal_bile_duct0.84546856
126MP0003880_abnormal_central_pattern0.84368374
127MP0003698_abnormal_male_reproductive0.83148401
128MP0008961_abnormal_basal_metabolism0.82259378
129MP0002075_abnormal_coat/hair_pigmentati0.82082379
130MP0003300_gastrointestinal_ulcer0.81826084
131MP0002693_abnormal_pancreas_physiology0.81460062
132MP0004947_skin_inflammation0.81080662
133MP0001529_abnormal_vocalization0.80968645
134MP0005367_renal/urinary_system_phenotyp0.79128113
135MP0000516_abnormal_urinary_system0.79128113
136MP0003077_abnormal_cell_cycle0.78991483
137MP0005646_abnormal_pituitary_gland0.78534537
138MP0010094_abnormal_chromosome_stability0.78384759
139MP0001851_eye_inflammation0.78013604
140MP0003656_abnormal_erythrocyte_physiolo0.77456727
141MP0001905_abnormal_dopamine_level0.76932634
142MP0002277_abnormal_respiratory_mucosa0.76533843
143MP0000631_abnormal_neuroendocrine_gland0.73892005
144MP0003136_yellow_coat_color0.70991479
145MP0000681_abnormal_thyroid_gland0.69233933
146MP0005386_behavior/neurological_phenoty0.69000357
147MP0004924_abnormal_behavior0.69000357
148MP0003718_maternal_effect0.68052433
149MP0005195_abnormal_posterior_eye0.67385885
150MP0002168_other_aberrant_phenotype0.66932145
151MP0000230_abnormal_systemic_arterial0.66679261
152MP0001944_abnormal_pancreas_morphology0.66619502
153MP0005332_abnormal_amino_acid0.66559599
154MP0002928_abnormal_bile_duct0.66045942
155MP0002132_abnormal_respiratory_system0.65632484
156MP0004742_abnormal_vestibular_system0.64698728
157MP0009384_cardiac_valve_regurgitation0.63568882
158MP0004215_abnormal_myocardial_fiber0.63110570
159MP0003303_peritoneal_inflammation0.62516368
160MP0002163_abnormal_gland_morphology0.60908247
161MP0003786_premature_aging0.60836738
162MP0001486_abnormal_startle_reflex0.59209610
163MP0006036_abnormal_mitochondrial_physio0.58612931

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)4.68430865
2Absent/shortened dynein arms (HP:0200106)4.68430865
3Medial flaring of the eyebrow (HP:0010747)4.58114729
4True hermaphroditism (HP:0010459)4.53882910
5Pancreatic fibrosis (HP:0100732)4.49735205
6Pancreatic cysts (HP:0001737)4.46777065
7Abnormal ciliary motility (HP:0012262)4.31887376
8Molar tooth sign on MRI (HP:0002419)4.27408027
9Abnormality of midbrain morphology (HP:0002418)4.27408027
10Abnormal respiratory motile cilium morphology (HP:0005938)4.21339145
11Abnormal respiratory epithelium morphology (HP:0012253)4.21339145
12IgM deficiency (HP:0002850)4.18371972
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.16729785
14Abnormal respiratory motile cilium physiology (HP:0012261)4.13756494
15Gastrointestinal stroma tumor (HP:0100723)3.96009159
16Nephronophthisis (HP:0000090)3.89050973
17Abnormal rod and cone electroretinograms (HP:0008323)3.86361834
18Congenital primary aphakia (HP:0007707)3.84006812
19Nephrogenic diabetes insipidus (HP:0009806)3.79531574
20Absent rod-and cone-mediated responses on ERG (HP:0007688)3.75185462
21Gait imbalance (HP:0002141)3.70365905
22Abnormal pupillary function (HP:0007686)3.65239395
23Reticulocytopenia (HP:0001896)3.61397835
24Abnormality of the renal cortex (HP:0011035)3.59208624
25Thrombocytosis (HP:0001894)3.57888962
26Prolonged bleeding time (HP:0003010)3.57438513
27Abnormality of the columella (HP:0009929)3.56677393
28Rhinitis (HP:0012384)3.55078612
29Agammaglobulinemia (HP:0004432)3.52968971
30Abnormality of cells of the erythroid lineage (HP:0012130)3.51772798
31Congenital stationary night blindness (HP:0007642)3.50557452
32Abnormality of the renal medulla (HP:0100957)3.48893758
33Recurrent bronchitis (HP:0002837)3.47017354
34Abnormal number of erythroid precursors (HP:0012131)3.42093247
35Hypoproteinemia (HP:0003075)3.23651205
36Severe visual impairment (HP:0001141)3.21599204
37B lymphocytopenia (HP:0010976)3.19355754
38Abnormality of B cell number (HP:0010975)3.19355754
39Abnormal glycosylation (HP:0012345)3.18274565
40Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.18274565
41Abnormal protein N-linked glycosylation (HP:0012347)3.18274565
42Abnormal protein glycosylation (HP:0012346)3.18274565
43Petechiae (HP:0000967)3.16701563
44Aplastic anemia (HP:0001915)3.14774446
45Decreased central vision (HP:0007663)3.14032407
46Renal cortical cysts (HP:0000803)3.13544502
47Gastrointestinal inflammation (HP:0004386)3.12120997
48Inflammation of the large intestine (HP:0002037)3.09754265
49Hepatocellular necrosis (HP:0001404)3.07166112
50Bronchiectasis (HP:0002110)3.05511593
51Attenuation of retinal blood vessels (HP:0007843)3.01246237
52Emphysema (HP:0002097)3.00158723
53Stomatitis (HP:0010280)2.99913731
54Cystic liver disease (HP:0006706)2.98355283
55Bony spicule pigmentary retinopathy (HP:0007737)2.97743654
56Genital tract atresia (HP:0001827)2.95704427
57Aplasia/Hypoplasia of the tongue (HP:0010295)2.86548428
58Postaxial foot polydactyly (HP:0001830)2.82470469
59Poor coordination (HP:0002370)2.81425354
60Vaginal atresia (HP:0000148)2.79533225
61Abnormal delayed hypersensitivity skin test (HP:0002963)2.78079980
62Tubulointerstitial nephritis (HP:0001970)2.76938707
63Recurrent sinusitis (HP:0011108)2.73808667
64Lymphopenia (HP:0001888)2.71211887
65Panhypogammaglobulinemia (HP:0003139)2.70815777
66Abnormality of cells of the lymphoid lineage (HP:0012140)2.66991555
67Pallor (HP:0000980)2.66654784
68Tubular atrophy (HP:0000092)2.63205566
69Congenital hepatic fibrosis (HP:0002612)2.57533964
70Constricted visual fields (HP:0001133)2.56163954
71Papilledema (HP:0001085)2.54513317
72Elevated erythrocyte sedimentation rate (HP:0003565)2.54455163
73Severe combined immunodeficiency (HP:0004430)2.51934436
74Chronic otitis media (HP:0000389)2.50265774
75Recurrent abscess formation (HP:0002722)2.49951734
76Abnormality of the heme biosynthetic pathway (HP:0010472)2.48447894
77Septate vagina (HP:0001153)2.47932323
78Epistaxis (HP:0000421)2.46761538
79IgG deficiency (HP:0004315)2.46546298
80Colitis (HP:0002583)2.46206262
81Impaired platelet aggregation (HP:0003540)2.44740187
82Abnormal platelet function (HP:0011869)2.44740187
83Chronic bronchitis (HP:0004469)2.44375049
84Recurrent viral infections (HP:0004429)2.43618500
85Recurrent bacterial skin infections (HP:0005406)2.41064792
86Type I transferrin isoform profile (HP:0003642)2.39984511
87Hyperventilation (HP:0002883)2.38426546
88Occipital encephalocele (HP:0002085)2.37871497
89Abnormality of macular pigmentation (HP:0008002)2.37229656
90Meningitis (HP:0001287)2.34424911
91Albinism (HP:0001022)2.34367709
92Abnormal hair whorl (HP:0010721)2.33698491
93Hepatic necrosis (HP:0002605)2.33060044
94Vasculitis (HP:0002633)2.32556360
95Cellulitis (HP:0100658)2.32309629
96Oculomotor apraxia (HP:0000657)2.28168843
97Postaxial hand polydactyly (HP:0001162)2.28097690
98Anencephaly (HP:0002323)2.25892410
99Hypothermia (HP:0002045)2.23148715
100Hypoplasia of the thymus (HP:0000778)2.23063191
101Abnormality of T cell physiology (HP:0011840)2.20711445
102Lymphoma (HP:0002665)2.20609309
103Aplasia/Hypoplasia of the tibia (HP:0005772)2.16811903
104Purpura (HP:0000979)2.16266413
105Progressive microcephaly (HP:0000253)2.14775646
106Back pain (HP:0003418)2.13016860
107Aplasia/Hypoplasia of the sacrum (HP:0008517)2.11907827
108Thyroiditis (HP:0100646)2.11286373
109Retinitis pigmentosa (HP:0000510)2.11179449
110Myositis (HP:0100614)2.10491068
111Mitochondrial inheritance (HP:0001427)2.10359385
112Recurrent pneumonia (HP:0006532)2.10137979
113Polydipsia (HP:0001959)2.08686616
114Abnormal drinking behavior (HP:0030082)2.08686616
115Chronic diarrhea (HP:0002028)2.05866297
116Male pseudohermaphroditism (HP:0000037)2.05507123
117Pendular nystagmus (HP:0012043)2.03766723
118Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.03082894
119Increased corneal curvature (HP:0100692)2.01805393
120Keratoconus (HP:0000563)2.01805393
121Optic nerve coloboma (HP:0000588)2.01444815
122Acute lymphatic leukemia (HP:0006721)2.00516489
123Furrowed tongue (HP:0000221)2.00436505
124Aplasia/Hypoplasia of the lens (HP:0008063)2.00341945
125Bile duct proliferation (HP:0001408)2.00162204
126Abnormal biliary tract physiology (HP:0012439)2.00162204
127Abnormality of T cells (HP:0002843)1.99999864
128Recurrent fungal infections (HP:0002841)1.99597721
129Chronic sinusitis (HP:0011109)1.98604633
130Sclerocornea (HP:0000647)1.98387466
131Broad foot (HP:0001769)1.98075011
132Bronchitis (HP:0012387)1.96800535
133Abolished electroretinogram (ERG) (HP:0000550)1.95696609
134Fatigue (HP:0012378)1.94930210
135Tubulointerstitial abnormality (HP:0001969)1.94929001
136Neutropenia (HP:0001875)1.94836059
137Astigmatism (HP:0000483)1.93872386
138Exertional dyspnea (HP:0002875)1.93241726
139Chronic hepatic failure (HP:0100626)1.93187032
140Visual hallucinations (HP:0002367)1.93104950
141Absent speech (HP:0001344)1.92516272
142Rectal prolapse (HP:0002035)1.92062355
143Recurrent skin infections (HP:0001581)1.91307815
144Prominent nasal bridge (HP:0000426)1.91127398
145Increased IgE level (HP:0003212)1.89608481
146Epileptic encephalopathy (HP:0200134)1.89342349
147Recurrent lower respiratory tract infections (HP:0002783)1.88937937
148Submucous cleft hard palate (HP:0000176)1.88438056
149Sloping forehead (HP:0000340)1.86110599
150Hemiparesis (HP:0001269)1.85803308
151Abnormality of oral frenula (HP:0000190)1.85444073
152Mediastinal lymphadenopathy (HP:0100721)1.83563140
153Recurrent cutaneous fungal infections (HP:0011370)1.82203676
154Chronic mucocutaneous candidiasis (HP:0002728)1.82203676
155Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81927694
156Myelodysplasia (HP:0002863)1.81647921
157Specific learning disability (HP:0001328)1.80834231
158Combined immunodeficiency (HP:0005387)1.80595555
159Tented upper lip vermilion (HP:0010804)1.79509757
160Leukopenia (HP:0001882)1.78761001
161Congenital sensorineural hearing impairment (HP:0008527)1.77920441
162Increased intramyocellular lipid droplets (HP:0012240)1.76793369
163Increased CSF lactate (HP:0002490)1.76600731
164Abnormality of eosinophils (HP:0001879)1.76427183
165Stomach cancer (HP:0012126)1.76247899
166Short foot (HP:0001773)1.74926600
167Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74600584
168Polyuria (HP:0000103)1.74322122
169Aganglionic megacolon (HP:0002251)1.73831478
170Median cleft lip (HP:0000161)1.72570926
171Ketoacidosis (HP:0001993)1.71931792
172Cone-rod dystrophy (HP:0000548)1.70841636
173Gaze-evoked nystagmus (HP:0000640)1.70464903
174Fair hair (HP:0002286)1.70064404
175Multicystic kidney dysplasia (HP:0000003)1.68592728
176Asplenia (HP:0001746)1.65115544
177Aplasia/Hypoplasia of the spleen (HP:0010451)1.64311707
178Protruding tongue (HP:0010808)1.63765182

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.22089331
2ACVR1B3.78949634
3CDK193.48426589
4RPS6KA43.42406640
5TNIK3.26028779
6MAP4K13.08752717
7MAP4K23.06881142
8KIT2.95685277
9NUAK12.77420967
10STK162.68574462
11WNK32.52571762
12TGFBR12.47823886
13GRK62.45657754
14PRKD22.42546907
15ADRBK22.29310197
16VRK12.25857087
17TYK22.08003279
18AKT32.03725977
19STK38L2.00284789
20BTK1.98129898
21FES1.92223147
22NME21.91431658
23SYK1.85456528
24BRD41.80844255
25SCYL21.78924296
26CSF1R1.77382202
27TEC1.76921517
28ERBB31.68352804
29MUSK1.67490064
30PRKCH1.66816322
31FLT31.64133885
32SRPK11.60822375
33MST41.56952819
34TRIM281.56918794
35CCNB11.56065513
36MAPK151.54666265
37TBK11.54095763
38BRSK21.50455934
39MAP3K61.45734430
40ERN11.41558198
41BMPR1B1.39746830
42LATS11.35551090
43PLK21.33535937
44CASK1.33495859
45JAK31.33010971
46IKBKE1.31011423
47PTK2B1.30707103
48MKNK21.27625714
49ZAK1.27089177
50ZAP701.26248835
51EEF2K1.24977694
52LRRK21.24579117
53DYRK31.21197581
54IRAK11.18536974
55EPHA31.15302327
56ITK1.13195186
57RPS6KA51.10469827
58LYN1.10226445
59FER1.09293396
60CLK11.08043397
61MAPKAPK31.05206135
62NLK1.03876338
63IRAK41.01750588
64LCK1.00170997
65TXK0.98754133
66TESK20.96378246
67YES10.95546866
68TGFBR20.93391567
69INSRR0.92986072
70HCK0.91983640
71RAF10.88886761
72BLK0.88091197
73MAPK130.87117878
74PAK30.86961465
75TLK10.86697701
76GRK10.86011644
77DAPK10.85770415
78NEK20.85607741
79STK390.84208942
80WNK40.82939884
81PASK0.81355366
82OXSR10.80616065
83PIK3CA0.79654543
84PRKD30.79140049
85MAPK40.77818209
86STK30.77584259
87SIK30.75043824
88RIPK40.73755048
89CSNK1G10.73505842
90BMPR20.73018953
91PINK10.72699739
92RPS6KB20.71879528
93MAP3K40.70653237
94FGFR30.70570574
95CDK90.69802508
96FGFR40.67209656
97IKBKB0.67012501
98MAP2K70.66955134
99PRKCE0.66521809
100CAMKK20.66164938
101BCR0.65579794
102MATK0.62246961
103CSNK1A1L0.61916758
104ABL10.58474460
105ERBB20.56523895
106DYRK1A0.55575536
107MAPK120.55485111
108RET0.54502836
109SGK20.53298297
110NEK10.52826638
111MYLK0.51831164
112WEE10.51721813
113CSNK1G30.51505367
114TNK20.50737836
115JAK10.50603548
116EIF2AK30.49316393
117TAOK30.48919760
118PLK30.47867005
119PLK40.47308702
120CDK60.46959828
121ILK0.45686534
122CSNK1G20.44611161
123PNCK0.44099941
124TRPM70.43850385
125CDK30.43710718
126JAK20.43482865
127ATM0.42065067
128PIM20.40201558
129FGFR20.39804816
130ADRBK10.39692981
131PRKCQ0.39141236
132TIE10.38884009
133EIF2AK20.37320267
134MAP3K120.37288959
135PIM10.36929222
136MAPK70.36700236
137BCKDK0.36691926
138CDK11A0.35886008
139ERBB40.34763064
140MAPKAPK50.34428244
141KDR0.33604167
142PIK3CG0.33389087
143CHEK20.32985875
144MKNK10.32553558
145CAMK1G0.32472682
146CDK70.32254687
147ATR0.30479930
148AURKB0.30443487
149MELK0.29752163
150IRAK20.29512095
151CDK180.28408450
152HIPK20.28360781
153BUB10.28129087
154CAMK10.27606245

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.91091547
2Primary immunodeficiency_Homo sapiens_hsa053403.84633325
3Ribosome_Homo sapiens_hsa030103.75259179
4Base excision repair_Homo sapiens_hsa034103.44047925
5Mismatch repair_Homo sapiens_hsa034303.08282755
6N-Glycan biosynthesis_Homo sapiens_hsa005102.90992230
7Homologous recombination_Homo sapiens_hsa034402.89957925
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.56563555
9Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.52978238
10Protein export_Homo sapiens_hsa030602.44289332
11Butanoate metabolism_Homo sapiens_hsa006502.40751412
12Linoleic acid metabolism_Homo sapiens_hsa005912.35986379
13Phototransduction_Homo sapiens_hsa047442.34482003
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.33441548
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.30277762
16Spliceosome_Homo sapiens_hsa030402.30274875
17Caffeine metabolism_Homo sapiens_hsa002322.16003942
18Propanoate metabolism_Homo sapiens_hsa006402.09244001
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.07405094
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.04973315
21Non-homologous end-joining_Homo sapiens_hsa034502.01007696
22Nucleotide excision repair_Homo sapiens_hsa034201.94229311
23Nitrogen metabolism_Homo sapiens_hsa009101.87476197
24B cell receptor signaling pathway_Homo sapiens_hsa046621.86021689
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81626252
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.77630135
27ABC transporters_Homo sapiens_hsa020101.77609242
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.75318593
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.65240662
30Ether lipid metabolism_Homo sapiens_hsa005651.61213480
31Regulation of autophagy_Homo sapiens_hsa041401.60827363
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56315385
33Systemic lupus erythematosus_Homo sapiens_hsa053221.55286614
34Chemical carcinogenesis_Homo sapiens_hsa052041.49709424
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.48464766
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47389977
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.45497598
38Tryptophan metabolism_Homo sapiens_hsa003801.45334128
39Hematopoietic cell lineage_Homo sapiens_hsa046401.44559421
40Peroxisome_Homo sapiens_hsa041461.42308425
41Antigen processing and presentation_Homo sapiens_hsa046121.36992848
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.35782467
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.33307149
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.32025222
45Asthma_Homo sapiens_hsa053101.29310975
46Other glycan degradation_Homo sapiens_hsa005111.29118668
47Pyrimidine metabolism_Homo sapiens_hsa002401.26130794
48Platelet activation_Homo sapiens_hsa046111.26126299
49Fanconi anemia pathway_Homo sapiens_hsa034601.22315311
50Proteasome_Homo sapiens_hsa030501.20061073
51Leishmaniasis_Homo sapiens_hsa051401.19597027
52Herpes simplex infection_Homo sapiens_hsa051681.18856337
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16388064
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12828220
55Alcoholism_Homo sapiens_hsa050341.09473389
56Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08243836
57Taste transduction_Homo sapiens_hsa047421.08059164
58Selenocompound metabolism_Homo sapiens_hsa004501.07030231
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07026855
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06452031
61T cell receptor signaling pathway_Homo sapiens_hsa046601.04999078
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04436073
63Steroid biosynthesis_Homo sapiens_hsa001001.03525661
64Dorso-ventral axis formation_Homo sapiens_hsa043201.03319873
65Retinol metabolism_Homo sapiens_hsa008301.02967930
66Arachidonic acid metabolism_Homo sapiens_hsa005901.01876395
67Measles_Homo sapiens_hsa051621.01407895
68Circadian rhythm_Homo sapiens_hsa047100.99803623
69beta-Alanine metabolism_Homo sapiens_hsa004100.98672444
70Olfactory transduction_Homo sapiens_hsa047400.97074386
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94951985
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87433697
73Pentose phosphate pathway_Homo sapiens_hsa000300.87145649
74Allograft rejection_Homo sapiens_hsa053300.85785517
75Renin secretion_Homo sapiens_hsa049240.84768061
76Cell cycle_Homo sapiens_hsa041100.83522698
77Purine metabolism_Homo sapiens_hsa002300.82538042
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81543212
79Lysine degradation_Homo sapiens_hsa003100.80639385
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80625609
81Morphine addiction_Homo sapiens_hsa050320.80162387
82Vibrio cholerae infection_Homo sapiens_hsa051100.79374878
83Shigellosis_Homo sapiens_hsa051310.79040561
84One carbon pool by folate_Homo sapiens_hsa006700.78779867
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77400885
86RNA degradation_Homo sapiens_hsa030180.76121142
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.75632335
88Osteoclast differentiation_Homo sapiens_hsa043800.74820492
89Glycerolipid metabolism_Homo sapiens_hsa005610.70759501
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.67387538
91Sulfur metabolism_Homo sapiens_hsa009200.67014672
92Collecting duct acid secretion_Homo sapiens_hsa049660.66304350
93Fatty acid degradation_Homo sapiens_hsa000710.65190422
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64998271
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64693569
96Graft-versus-host disease_Homo sapiens_hsa053320.64552378
97Tuberculosis_Homo sapiens_hsa051520.64078526
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.63515372
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.63330445
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60093568
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56127680
102GABAergic synapse_Homo sapiens_hsa047270.56008638
103Malaria_Homo sapiens_hsa051440.55402558
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55296353
105Hepatitis B_Homo sapiens_hsa051610.54635299
106Circadian entrainment_Homo sapiens_hsa047130.52262121
107Histidine metabolism_Homo sapiens_hsa003400.51935611
108Ovarian steroidogenesis_Homo sapiens_hsa049130.51176351
109Legionellosis_Homo sapiens_hsa051340.51064069
110Metabolic pathways_Homo sapiens_hsa011000.50380196
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50261462
112Epstein-Barr virus infection_Homo sapiens_hsa051690.49311131
113p53 signaling pathway_Homo sapiens_hsa041150.48074888
114Phagosome_Homo sapiens_hsa041450.48006487
115Galactose metabolism_Homo sapiens_hsa000520.47247245
116Oxidative phosphorylation_Homo sapiens_hsa001900.47012861
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.45520797
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45481380
119Chemokine signaling pathway_Homo sapiens_hsa040620.45246430
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44859652
121Pertussis_Homo sapiens_hsa051330.44590488
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44193269
123Autoimmune thyroid disease_Homo sapiens_hsa053200.44096287
124Influenza A_Homo sapiens_hsa051640.42166933
125RNA transport_Homo sapiens_hsa030130.41164686
126Salivary secretion_Homo sapiens_hsa049700.39187133
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39180400
128Parkinsons disease_Homo sapiens_hsa050120.39050221
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.38274888
130Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38011915
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37959326
132Nicotine addiction_Homo sapiens_hsa050330.37595595
133Alzheimers disease_Homo sapiens_hsa050100.37346518
134Pancreatic cancer_Homo sapiens_hsa052120.36601362
135NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36512920
136Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35484274
137Huntingtons disease_Homo sapiens_hsa050160.35044390
138Viral carcinogenesis_Homo sapiens_hsa052030.34976946
139Sulfur relay system_Homo sapiens_hsa041220.34940946
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.33581794
141African trypanosomiasis_Homo sapiens_hsa051430.33208347
142Fatty acid metabolism_Homo sapiens_hsa012120.32203263
143Basal transcription factors_Homo sapiens_hsa030220.31226732
144Type I diabetes mellitus_Homo sapiens_hsa049400.30134776
145RNA polymerase_Homo sapiens_hsa030200.29749112
146Staphylococcus aureus infection_Homo sapiens_hsa051500.28748185
147Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28349676
148Lysosome_Homo sapiens_hsa041420.28081902
149Rheumatoid arthritis_Homo sapiens_hsa053230.27535617
150Drug metabolism - other enzymes_Homo sapiens_hsa009830.26918075
151Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26782852
152Non-small cell lung cancer_Homo sapiens_hsa052230.26283232
153Acute myeloid leukemia_Homo sapiens_hsa052210.25825123
154Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.25367450
155Serotonergic synapse_Homo sapiens_hsa047260.24636241
156Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24624740
157Sphingolipid metabolism_Homo sapiens_hsa006000.24019242
158Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23254691
159Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23117513

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