WDR6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. The encoded protein interacts with serine/threonine kinase 11, and is implicated in cell growth arrest. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.75797017
2layer formation in cerebral cortex (GO:0021819)5.39531185
3synaptic vesicle maturation (GO:0016188)5.05733515
4response to pheromone (GO:0019236)5.01959291
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.98601733
6pyrimidine nucleobase catabolic process (GO:0006208)4.80730552
7planar cell polarity pathway involved in neural tube closure (GO:0090179)4.60017442
8locomotory exploration behavior (GO:0035641)4.44003248
9neuron cell-cell adhesion (GO:0007158)4.28434485
10semaphorin-plexin signaling pathway (GO:0071526)4.28081449
11regulation of synaptic vesicle exocytosis (GO:2000300)4.24459174
12regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.19995903
13synaptic vesicle exocytosis (GO:0016079)4.10061524
14negative regulation of microtubule polymerization (GO:0031115)4.08683415
15mannose metabolic process (GO:0006013)4.05911698
16dendritic spine morphogenesis (GO:0060997)4.05829216
17axonal fasciculation (GO:0007413)3.97919112
18vocalization behavior (GO:0071625)3.97546820
19protein localization to synapse (GO:0035418)3.96703337
20negative regulation of cell size (GO:0045792)3.96045072
21spliceosomal tri-snRNP complex assembly (GO:0000244)3.92922708
22cerebellar Purkinje cell layer development (GO:0021680)3.92166349
23neuron recognition (GO:0008038)3.88363478
24cell migration in hindbrain (GO:0021535)3.87664201
25exploration behavior (GO:0035640)3.85376747
26regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.77879840
27adherens junction assembly (GO:0034333)3.76807707
28negative regulation of erythrocyte differentiation (GO:0045647)3.76756133
29glutamate secretion (GO:0014047)3.75144926
30regulation of synaptic vesicle transport (GO:1902803)3.68420091
31dendrite morphogenesis (GO:0048813)3.68042610
32neurotransmitter secretion (GO:0007269)3.62784515
33positive regulation of synaptic transmission, GABAergic (GO:0032230)3.60953579
34regulation of histone H3-K27 methylation (GO:0061085)3.60364325
35nucleobase catabolic process (GO:0046113)3.58321837
36proline biosynthetic process (GO:0006561)3.56007104
37regulation of glutamate receptor signaling pathway (GO:1900449)3.54398798
38proline transport (GO:0015824)3.54241853
39positive regulation of synapse maturation (GO:0090129)3.53421668
40histone H4 deacetylation (GO:0070933)3.53158247
41cell-substrate adherens junction assembly (GO:0007045)3.51615906
42focal adhesion assembly (GO:0048041)3.51615906
43activation of protein kinase A activity (GO:0034199)3.50013765
44apoptotic process involved in morphogenesis (GO:0060561)3.49613594
45protein retention in ER lumen (GO:0006621)3.48364203
46epithelial cell differentiation involved in prostate gland development (GO:0060742)3.46538268
47positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.46397379
48cytoskeletal anchoring at plasma membrane (GO:0007016)3.45599345
49activation of Rac GTPase activity (GO:0032863)3.45451061
50synaptic vesicle docking involved in exocytosis (GO:0016081)3.42453476
51innervation (GO:0060384)3.41868747
52convergent extension (GO:0060026)3.39073757
53regulation of glucose import in response to insulin stimulus (GO:2001273)3.38282355
54regulation of synapse structural plasticity (GO:0051823)3.38011887
55maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.37969253
56Golgi transport vesicle coating (GO:0048200)3.34034876
57COPI coating of Golgi vesicle (GO:0048205)3.34034876
58central nervous system projection neuron axonogenesis (GO:0021952)3.33379007
59snRNA metabolic process (GO:0016073)3.31918875
60cell communication by electrical coupling (GO:0010644)3.28244758
61intracellular estrogen receptor signaling pathway (GO:0030520)3.26725663
62cerebellum development (GO:0021549)3.25534677
63regulation of NFAT protein import into nucleus (GO:0051532)3.25422633
64postsynaptic membrane organization (GO:0001941)3.23149949
653-UTR-mediated mRNA stabilization (GO:0070935)3.19220670
66axon cargo transport (GO:0008088)3.17571983
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.17211041
68nucleosome disassembly (GO:0006337)3.16840542
69protein-DNA complex disassembly (GO:0032986)3.16840542
70positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.13301573
71maternal placenta development (GO:0001893)3.13037267
72histone H3 deacetylation (GO:0070932)3.11495709
73cellular response to epidermal growth factor stimulus (GO:0071364)3.09247946
74regulation of mammary gland epithelial cell proliferation (GO:0033599)3.07643611
75auditory behavior (GO:0031223)3.06062737
76synaptic vesicle endocytosis (GO:0048488)3.05429972
77snRNA processing (GO:0016180)3.04367871
78establishment of nucleus localization (GO:0040023)3.04331166
79activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.00957025
80regulation of ARF GTPase activity (GO:0032312)3.00606114
81endothelial cell chemotaxis (GO:0035767)3.00105162
82regulation of neuronal synaptic plasticity (GO:0048168)2.99433698
83organelle transport along microtubule (GO:0072384)2.97473058
84ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.97015537
85axon extension (GO:0048675)2.94433111
86mating behavior (GO:0007617)2.94088968
87response to auditory stimulus (GO:0010996)2.94074756
88regulation of calcium ion-dependent exocytosis (GO:0017158)2.93224429
89basement membrane organization (GO:0071711)2.93217242
90positive regulation of dendritic spine morphogenesis (GO:0061003)2.90203678
91positive regulation of nuclease activity (GO:0032075)2.90013183
92histone H3-K36 demethylation (GO:0070544)2.89022121
93synapse assembly (GO:0007416)2.88672354
94cell-cell junction maintenance (GO:0045217)2.88613435
95negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.88266742
96insulin-like growth factor receptor signaling pathway (GO:0048009)2.87744393
97mRNA stabilization (GO:0048255)2.86846257
98RNA stabilization (GO:0043489)2.86846257
99cellular potassium ion homeostasis (GO:0030007)2.86303496
100regulation of long-term neuronal synaptic plasticity (GO:0048169)2.86105573
101epithelial cell-cell adhesion (GO:0090136)2.85974079
102vesicle transport along microtubule (GO:0047496)2.85259332
103positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.85259144
104mitochondrion transport along microtubule (GO:0047497)2.84290873
105establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.84290873
106cell-substrate junction assembly (GO:0007044)2.83019516
107clathrin coat assembly (GO:0048268)2.82746048
108neurotransmitter transport (GO:0006836)2.82364236
109Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.81908044
110regulation of cAMP-dependent protein kinase activity (GO:2000479)2.81712310
111cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.80149933
112pentose-phosphate shunt (GO:0006098)2.79968248
113peptidyl-tyrosine autophosphorylation (GO:0038083)2.79555713
114regulation of vesicle fusion (GO:0031338)2.77789065
115cellular response to prostaglandin stimulus (GO:0071379)2.77512196
116regulation of nucleobase-containing compound transport (GO:0032239)2.76676104
117regulation of chromatin binding (GO:0035561)2.76454773
118regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.76272764
119sodium ion export (GO:0071436)2.76200738
120regulation of RNA export from nucleus (GO:0046831)2.74603149
121synapse organization (GO:0050808)2.74475514
122regulation of extracellular matrix disassembly (GO:0010715)2.72850920
123cerebellar Purkinje cell differentiation (GO:0021702)2.72330868
124positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.71597577
125ear development (GO:0043583)2.70394227
126stress granule assembly (GO:0034063)2.68862652
127neuromuscular process controlling balance (GO:0050885)2.68368734
128dopamine receptor signaling pathway (GO:0007212)2.68064447
129regulation of cholesterol biosynthetic process (GO:0045540)2.67694962
130protein localization to endosome (GO:0036010)2.67462205
131positive regulation of synapse assembly (GO:0051965)2.67158325
132dendritic spine organization (GO:0097061)2.66743898
133regulation of establishment of planar polarity (GO:0090175)2.65290993
134regulation of nuclease activity (GO:0032069)2.63849810
135negative regulation of catenin import into nucleus (GO:0035414)2.63479666
136cellular response to glucagon stimulus (GO:0071377)2.63039746
137regulation of axon extension (GO:0030516)2.60978355
138regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.60122935
139regulation of respiratory system process (GO:0044065)2.59942093
140histone deacetylation (GO:0016575)2.59241029
141regulation of ARF protein signal transduction (GO:0032012)2.58739183
142entrainment of circadian clock by photoperiod (GO:0043153)2.58613172
143homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.58585126
144neuron projection extension (GO:1990138)2.54978456
145positive regulation of blood vessel endothelial cell migration (GO:0043536)2.53549149
146ionotropic glutamate receptor signaling pathway (GO:0035235)2.53531557
147glucose catabolic process (GO:0006007)2.53094805
148peptidyl-arginine methylation (GO:0018216)2.52983428
149peptidyl-arginine N-methylation (GO:0035246)2.52983428
150intraspecies interaction between organisms (GO:0051703)2.52710702
151social behavior (GO:0035176)2.52710702
152cell volume homeostasis (GO:0006884)2.52696029
153atrioventricular valve morphogenesis (GO:0003181)2.52494472
154regulation of neurotransmitter levels (GO:0001505)2.52178310
155potassium ion homeostasis (GO:0055075)2.51825903
156central nervous system neuron axonogenesis (GO:0021955)2.51555993
157histone lysine demethylation (GO:0070076)2.51487395
158establishment of mitochondrion localization (GO:0051654)2.51435609
159neuron migration (GO:0001764)2.51334507
160embryonic process involved in female pregnancy (GO:0060136)2.50941003
161retrograde transport, endosome to Golgi (GO:0042147)2.50731903
162gamma-aminobutyric acid transport (GO:0015812)2.50722350
163response to epidermal growth factor (GO:0070849)2.50607655
164hippocampus development (GO:0021766)2.49307048
165synaptic vesicle transport (GO:0048489)2.48937862
166establishment of synaptic vesicle localization (GO:0097480)2.48937862
167positive regulation of axon extension (GO:0045773)2.48866224
168regulation of axon guidance (GO:1902667)2.48348634
169establishment of vesicle localization (GO:0051650)2.48178439
170insulin secretion (GO:0030073)2.48112176
171proline metabolic process (GO:0006560)2.48004326
172endoplasmic reticulum unfolded protein response (GO:0030968)2.47039781
173retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.47015765
174synaptic transmission, glutamatergic (GO:0035249)2.46988985
175peptidyl-arginine omega-N-methylation (GO:0035247)2.46899438
176stress fiber assembly (GO:0043149)2.46599408
177establishment of apical/basal cell polarity (GO:0035089)2.46231573
178negative regulation of myotube differentiation (GO:0010832)2.45706278
179NADPH regeneration (GO:0006740)2.42834490
180poly(A)+ mRNA export from nucleus (GO:0016973)2.42532967
181DNA unwinding involved in DNA replication (GO:0006268)2.40308293
182ER-nucleus signaling pathway (GO:0006984)2.38288088
183regulation of cholesterol homeostasis (GO:2000188)2.38251085
184embryonic eye morphogenesis (GO:0048048)2.37737683
185modulation by virus of host morphology or physiology (GO:0019048)2.36110116
186cellular response to interleukin-4 (GO:0071353)2.35792236
187eye morphogenesis (GO:0048592)2.34995271
188histone demethylation (GO:0016577)2.34694534
189barbed-end actin filament capping (GO:0051016)2.33843059
190regulation of cholesterol metabolic process (GO:0090181)2.33796934
191glucocorticoid receptor signaling pathway (GO:0042921)2.33545196
192regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.33266198
193thymic T cell selection (GO:0045061)2.33123640
194histone H3-K9 demethylation (GO:0033169)2.33118733
195histone arginine methylation (GO:0034969)2.32052100

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.08188593
2CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.68273032
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.14467827
4MYC_22102868_ChIP-Seq_BL_Human3.02545825
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.00232208
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.86755071
7REST_21632747_ChIP-Seq_MESCs_Mouse2.76580914
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.73561021
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69806899
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.66971887
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.64753243
12VDR_21846776_ChIP-Seq_THP-1_Human2.58611528
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58409169
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.56451383
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.52817902
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51937448
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.47769959
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.47163887
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42478438
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42478438
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42373060
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.41633102
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.41460784
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.39315344
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33300860
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32557563
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32052156
28* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.26852627
29RARB_27405468_Chip-Seq_BRAIN_Mouse2.23867035
30RACK7_27058665_Chip-Seq_MCF-7_Human2.23632871
31TCF7_22412390_ChIP-Seq_EML_Mouse2.23000992
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21910820
33DROSHA_22980978_ChIP-Seq_HELA_Human2.20224697
34MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18387703
35RNF2_27304074_Chip-Seq_ESCs_Mouse2.17357966
36RARG_19884340_ChIP-ChIP_MEFs_Mouse2.16877709
37ZNF263_19887448_ChIP-Seq_K562_Human2.13576740
38EED_16625203_ChIP-ChIP_MESCs_Mouse2.12716544
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.08321549
40GBX2_23144817_ChIP-Seq_PC3_Human2.00190375
41ZNF274_21170338_ChIP-Seq_K562_Hela1.99875369
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.90110311
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.87648725
44* CLOCK_20551151_ChIP-Seq_293T_Human1.85169378
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.80090070
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78809804
47OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.78176046
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72068407
49TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.71757468
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.66810284
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66695317
52IGF1R_20145208_ChIP-Seq_DFB_Human1.65292068
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.65255268
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.63065057
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61937037
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61908249
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.59683186
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.58921014
59* P68_20966046_ChIP-Seq_HELA_Human1.55944386
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.54765828
61* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.54514032
62P300_27058665_Chip-Seq_ZR-75-30cells_Human1.53399562
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53055845
64RING1B_27294783_Chip-Seq_NPCs_Mouse1.52834164
65* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.52467656
66KDM2B_26808549_Chip-Seq_K562_Human1.51900249
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51724908
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.51419933
69* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.51280849
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.50483854
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.50122009
72* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47002201
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46028759
74CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.45869461
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.45459652
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45162299
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45114109
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.43276336
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.43122532
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43049697
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42099506
82TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.41488285
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.41268398
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.41262794
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40492882
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39278670
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38712240
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32805482
89TP53_22127205_ChIP-Seq_IMR90_Human1.32221925
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30700533
91RUNX1_27514584_Chip-Seq_MCF-7_Human1.30334224
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30057969
93* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.27888790
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27479194
95MAF_26560356_Chip-Seq_TH1_Human1.26784976
96AR_19668381_ChIP-Seq_PC3_Human1.26442827
97CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.25297223
98RNF2_27304074_Chip-Seq_NSC_Mouse1.24679934
99* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24470685
100NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23179009
101* UTX_26944678_Chip-Seq_JUKART_Human1.21485132
102MAF_26560356_Chip-Seq_TH2_Human1.21406386
103CIITA_25753668_ChIP-Seq_RAJI_Human1.21038492
104KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17955561
105SOX2_21211035_ChIP-Seq_LN229_Gbm1.16881344
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16653218
107SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.16636372
108NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16547686
109YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15206194
110* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14429767
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13453417
112AR_21572438_ChIP-Seq_LNCaP_Human1.13024635
113SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12917730
114TP53_20018659_ChIP-ChIP_R1E_Mouse1.12560652
115NCOR1_26117541_ChIP-Seq_K562_Human1.11575764
116CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11502723
117E2F7_22180533_ChIP-Seq_HELA_Human1.11197462
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10191421
119POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09577507
120SMAD3_21741376_ChIP-Seq_ESCs_Human1.09092682
121* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08877152
122ELF1_20517297_ChIP-Seq_JURKAT_Human1.08840841
123STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08783512
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08354386
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07954823
126ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07902952
127RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06707234
128RARB_24833708_ChIP-Seq_LIVER_Mouse1.05254778
129SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05058334
130ATF3_27146783_Chip-Seq_COLON_Human1.04982954
131VDR_24763502_ChIP-Seq_THP-1_Human1.04668216
132FOXM1_23109430_ChIP-Seq_U2OS_Human1.04000929
133CTCF_27219007_Chip-Seq_Bcells_Human1.03033408
134SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02639263
135KDM2B_26808549_Chip-Seq_JURKAT_Human1.02561162
136RUNX1_22412390_ChIP-Seq_EML_Mouse1.01892512
137* XRN2_22483619_ChIP-Seq_HELA_Human1.01741829
138E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01052517
139TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00564021
140MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00410474
141RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00210419
142TET1_21490601_ChIP-Seq_MESCs_Mouse1.00108168
143TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.00038918
144SOX3_22085726_ChIP-Seq_NPCs_Mouse0.97491433
145HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97230511
146ISL1_27105846_Chip-Seq_CPCs_Mouse0.97093082
147RARA_24833708_ChIP-Seq_LIVER_Mouse0.96641747
148ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96587826
149KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95903668
150NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95777511
151NANOG_21062744_ChIP-ChIP_HESCs_Human0.95520515
152SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95161301
153SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93414906
154KDM2B_26808549_Chip-Seq_DND41_Human0.91967928
155* LXR_22292898_ChIP-Seq_THP-1_Human0.91407920
156SMAD4_21799915_ChIP-Seq_A2780_Human0.90816194
157ELK4_26923725_Chip-Seq_MESODERM_Mouse0.90541839
158CREB1_26743006_Chip-Seq_LNCaP_Human0.90327057
159PKCTHETA_26484144_Chip-Seq_BREAST_Human0.89250872
160POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.87700725
161SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87237639
162ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86059593
163FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.85572409
164SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85535679
165SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85530414
166P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84618979
167HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.83813721
168SMC4_20622854_ChIP-Seq_HELA_Human0.81643854
169GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81639355
170REST_19997604_ChIP-ChIP_NEURONS_Mouse0.81610348
171* SMAD4_21741376_ChIP-Seq_HESCs_Human0.81576794
172TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81145841
173STAT3_23295773_ChIP-Seq_U87_Human0.80701105

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.62663071
2MP0004859_abnormal_synaptic_plasticity4.09509255
3MP0003122_maternal_imprinting3.72129048
4MP0001849_ear_inflammation3.39539583
5MP0003283_abnormal_digestive_organ2.93768934
6MP0005423_abnormal_somatic_nervous2.91668290
7MP0003635_abnormal_synaptic_transmissio2.88894973
8MP0004270_analgesia2.71216309
9MP0003880_abnormal_central_pattern2.66975648
10MP0002909_abnormal_adrenal_gland2.51893017
11MP0005058_abnormal_lysosome_morphology2.50733150
12MP0005645_abnormal_hypothalamus_physiol2.44479473
13MP0009780_abnormal_chondrocyte_physiolo2.43091060
14MP0003566_abnormal_cell_adhesion2.41474568
15MP0008260_abnormal_autophagy2.41386011
16MP0008438_abnormal_cutaneous_collagen2.36537106
17MP0002063_abnormal_learning/memory/cond2.33902619
18MP0000778_abnormal_nervous_system2.32768448
19MP0005451_abnormal_body_composition2.14581299
20MP0006276_abnormal_autonomic_nervous2.13371947
21MP0003121_genomic_imprinting2.09034138
22MP0002184_abnormal_innervation2.05874888
23MP0000566_synostosis2.03805756
24MP0002734_abnormal_mechanical_nocicepti2.01844407
25MP0009278_abnormal_bone_marrow2.01690817
26MP0006072_abnormal_retinal_apoptosis1.96346956
27MP0000569_abnormal_digit_pigmentation1.93855615
28MP0009745_abnormal_behavioral_response1.91467598
29MP0009384_cardiac_valve_regurgitation1.87331877
30MP0004858_abnormal_nervous_system1.85857187
31MP0003091_abnormal_cell_migration1.85222808
32MP0000013_abnormal_adipose_tissue1.84516084
33MP0002572_abnormal_emotion/affect_behav1.81489170
34MP0002064_seizures1.80127297
35MP0002733_abnormal_thermal_nociception1.79762957
36MP0005257_abnormal_intraocular_pressure1.79263411
37MP0000955_abnormal_spinal_cord1.78395285
38MP0002249_abnormal_larynx_morphology1.78061340
39MP0003787_abnormal_imprinting1.76795548
40MP0002557_abnormal_social/conspecific_i1.74317501
41MP0008961_abnormal_basal_metabolism1.72981254
42MP0002653_abnormal_ependyma_morphology1.72862358
43MP0004811_abnormal_neuron_physiology1.71981432
44MP0001968_abnormal_touch/_nociception1.70912141
45MP0001958_emphysema1.70734685
46MP0003123_paternal_imprinting1.68409412
47MP0000631_abnormal_neuroendocrine_gland1.62298810
48MP0002638_abnormal_pupillary_reflex1.61681693
49MP0000537_abnormal_urethra_morphology1.60851706
50MP0010386_abnormal_urinary_bladder1.59414788
51MP0001730_embryonic_growth_arrest1.55185370
52MP0005409_darkened_coat_color1.54806052
53MP0002234_abnormal_pharynx_morphology1.51377965
54MP0004272_abnormal_basement_membrane1.51128599
55MP0010234_abnormal_vibrissa_follicle1.48493344
56MP0001486_abnormal_startle_reflex1.48469455
57MP0003115_abnormal_respiratory_system1.48017980
58MP0009672_abnormal_birth_weight1.47242353
59MP0009046_muscle_twitch1.46771100
60MP0001529_abnormal_vocalization1.45804380
61MP0002882_abnormal_neuron_morphology1.44308446
62MP0004233_abnormal_muscle_weight1.43383951
63MP0000733_abnormal_muscle_development1.43285330
64MP0001970_abnormal_pain_threshold1.42889218
65MP0001502_abnormal_circadian_rhythm1.42524131
66MP0004185_abnormal_adipocyte_glucose1.41225006
67MP0003279_aneurysm1.35818403
68MP0001984_abnormal_olfaction1.35545464
69MP0005187_abnormal_penis_morphology1.34695314
70MP0004885_abnormal_endolymph1.34143648
71MP0001440_abnormal_grooming_behavior1.33941918
72MP0004264_abnormal_extraembryonic_tissu1.33935928
73MP0002272_abnormal_nervous_system1.33479251
74MP0002822_catalepsy1.32206671
75MP0002152_abnormal_brain_morphology1.32181707
76MP0003119_abnormal_digestive_system1.32090616
77MP0002067_abnormal_sensory_capabilities1.31062325
78MP0002396_abnormal_hematopoietic_system1.30777361
79MP0004924_abnormal_behavior1.28217324
80MP0005386_behavior/neurological_phenoty1.28217324
81MP0005375_adipose_tissue_phenotype1.27472248
82MP0003183_abnormal_peptide_metabolism1.24547398
83MP0000534_abnormal_ureter_morphology1.23950934
84MP0003300_gastrointestinal_ulcer1.23367541
85MP0005646_abnormal_pituitary_gland1.21844315
86MP0003861_abnormal_nervous_system1.21403115
87MP0002751_abnormal_autonomic_nervous1.20718533
88MP0002735_abnormal_chemical_nociception1.17612518
89MP0005253_abnormal_eye_physiology1.17430819
90MP0005499_abnormal_olfactory_system1.17293832
91MP0005394_taste/olfaction_phenotype1.17293832
92MP0002009_preneoplasia1.15576468
93MP0000579_abnormal_nail_morphology1.15546006
94MP0000767_abnormal_smooth_muscle1.15206944
95MP0003453_abnormal_keratinocyte_physiol1.13955561
96MP0005621_abnormal_cell_physiology1.12518055
97MP0003329_amyloid_beta_deposits1.12280311
98MP0002060_abnormal_skin_morphology1.11870586
99MP0001944_abnormal_pancreas_morphology1.11340484
100MP0003111_abnormal_nucleus_morphology1.10921356
101MP0005551_abnormal_eye_electrophysiolog1.09743390
102MP0003942_abnormal_urinary_system1.09402908
103MP0005666_abnormal_adipose_tissue1.09213292
104MP0002066_abnormal_motor_capabilities/c1.08291847
105MP0004808_abnormal_hematopoietic_stem1.06662272
106MP0008569_lethality_at_weaning1.06300561
107MP0001299_abnormal_eye_distance/1.06282772
108MP0010630_abnormal_cardiac_muscle1.02195229
109MP0001348_abnormal_lacrimal_gland1.01433748
110MP0004197_abnormal_fetal_growth/weight/1.01273992
111MP0003984_embryonic_growth_retardation0.99419827
112MP0002736_abnormal_nociception_after0.98233708
113MP0002080_prenatal_lethality0.97852997
114MP0003890_abnormal_embryonic-extraembry0.97558420
115MP0001501_abnormal_sleep_pattern0.97340690
116MP0000747_muscle_weakness0.95857023
117MP0002116_abnormal_craniofacial_bone0.94794432
118MP0001672_abnormal_embryogenesis/_devel0.93911265
119MP0005380_embryogenesis_phenotype0.93911265
120MP0002752_abnormal_somatic_nervous0.93886688
121MP0004947_skin_inflammation0.93634998
122MP0002069_abnormal_eating/drinking_beha0.93485205
123MP0000428_abnormal_craniofacial_morphol0.93337514
124MP0001915_intracranial_hemorrhage0.92688615
125MP0002932_abnormal_joint_morphology0.92046322
126MP0002088_abnormal_embryonic_growth/wei0.91842108
127MP0008789_abnormal_olfactory_epithelium0.91295695
128MP0000467_abnormal_esophagus_morphology0.90827106
129MP0005501_abnormal_skin_physiology0.89554101
130MP0000462_abnormal_digestive_system0.89427560
131MP0002697_abnormal_eye_size0.89147453
132MP0000003_abnormal_adipose_tissue0.88286592
133MP0002086_abnormal_extraembryonic_tissu0.88147341
134MP0000350_abnormal_cell_proliferation0.87251185
135MP0004087_abnormal_muscle_fiber0.87007298
136MP0001661_extended_life_span0.86974940
137MP0002896_abnormal_bone_mineralization0.86929309
138MP0003879_abnormal_hair_cell0.86822738
139MP0002925_abnormal_cardiovascular_devel0.86388173
140MP0009703_decreased_birth_body0.85375501
141MP0003634_abnormal_glial_cell0.85279268
142MP0005623_abnormal_meninges_morphology0.85131143
143MP0002254_reproductive_system_inflammat0.84990953
144MP0002092_abnormal_eye_morphology0.84556383
145MP0002085_abnormal_embryonic_tissue0.84468893
146MP0001346_abnormal_lacrimal_gland0.83656407
147MP0002166_altered_tumor_susceptibility0.82965758
148MP0006138_congestive_heart_failure0.82256576
149MP0000678_abnormal_parathyroid_gland0.81958979
150MP0010030_abnormal_orbit_morphology0.80979165
151MP0002877_abnormal_melanocyte_morpholog0.80861686
152MP0003385_abnormal_body_wall0.80337914
153MP0000477_abnormal_intestine_morphology0.80001837
154MP0004133_heterotaxia0.79944200
155MP0005503_abnormal_tendon_morphology0.79740401
156MP0002084_abnormal_developmental_patter0.79539179
157MP0003959_abnormal_lean_body0.79524161
158MP0005508_abnormal_skeleton_morphology0.79217624
159MP0002081_perinatal_lethality0.78902319
160MP0000759_abnormal_skeletal_muscle0.78847836
161MP0000432_abnormal_head_morphology0.77415190
162MP0004145_abnormal_muscle_electrophysio0.77181518
163MP0000751_myopathy0.76863176
164MP0001614_abnormal_blood_vessel0.76497855
165MP0005076_abnormal_cell_differentiation0.75883105
166MP0000858_altered_metastatic_potential0.75441307
167MP0002970_abnormal_white_adipose0.73674589
168MP0010368_abnormal_lymphatic_system0.73103234
169MP0002089_abnormal_postnatal_growth/wei0.73100161
170MP0002693_abnormal_pancreas_physiology0.72012003
171MP0002229_neurodegeneration0.71113252
172MP0001943_abnormal_respiration0.70547453
173MP0005379_endocrine/exocrine_gland_phen0.69780223
174MP0003172_abnormal_lysosome_physiology0.69320428
175MP0006292_abnormal_olfactory_placode0.68611476
176MP0005391_vision/eye_phenotype0.65846905

Predicted human phenotypes

RankGene SetZ-score
1Broad face (HP:0000283)4.08552136
2Visual hallucinations (HP:0002367)3.95220442
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.85331125
4Obstructive sleep apnea (HP:0002870)3.41822507
5Limb dystonia (HP:0002451)3.30637864
6Papilledema (HP:0001085)3.28576933
7Protrusio acetabuli (HP:0003179)3.25216895
8Supranuclear gaze palsy (HP:0000605)3.24755343
9Cervical subluxation (HP:0003308)3.24297266
10Agitation (HP:0000713)3.15511278
11Ankle clonus (HP:0011448)3.12057084
12Failure to thrive in infancy (HP:0001531)3.09744906
13Biconcave vertebral bodies (HP:0004586)3.07712751
14Myokymia (HP:0002411)3.06989046
15Insomnia (HP:0100785)3.02222884
16Hyperacusis (HP:0010780)2.99343092
17Shallow orbits (HP:0000586)2.94121810
18Ulnar bowing (HP:0003031)2.93102321
19Premature rupture of membranes (HP:0001788)2.86385697
20Mutism (HP:0002300)2.86315175
21Cerebral aneurysm (HP:0004944)2.83221653
22Depression (HP:0000716)2.73444049
23Amyotrophic lateral sclerosis (HP:0007354)2.72309131
24Bronchomalacia (HP:0002780)2.70882692
25Hypoventilation (HP:0002791)2.70684018
26Focal seizures (HP:0007359)2.70577605
27Renal duplication (HP:0000075)2.64944062
28Flat acetabular roof (HP:0003180)2.63724992
29Macroorchidism (HP:0000053)2.63559646
30Neoplasm of the heart (HP:0100544)2.62479873
31J-shaped sella turcica (HP:0002680)2.62274261
32Upper limb amyotrophy (HP:0009129)2.56548600
33Distal upper limb amyotrophy (HP:0007149)2.56548600
34Turricephaly (HP:0000262)2.54684683
35Elfin facies (HP:0004428)2.48475820
36Polyphagia (HP:0002591)2.47097802
37EEG with generalized epileptiform discharges (HP:0011198)2.45857447
38Metaphyseal cupping (HP:0003021)2.44718126
39Thin bony cortex (HP:0002753)2.43792894
40Megalencephaly (HP:0001355)2.40813248
41Epileptic encephalopathy (HP:0200134)2.39633537
42Distal lower limb amyotrophy (HP:0008944)2.38598939
43Shoulder girdle muscle weakness (HP:0003547)2.37605841
44Long palpebral fissure (HP:0000637)2.37602786
45Mitral regurgitation (HP:0001653)2.36225673
46Abnormality of the lower motor neuron (HP:0002366)2.35607816
47Hypsarrhythmia (HP:0002521)2.35193061
48Focal motor seizures (HP:0011153)2.33787751
49Epileptiform EEG discharges (HP:0011182)2.32819023
50Excessive salivation (HP:0003781)2.32672323
51Drooling (HP:0002307)2.32672323
52Lissencephaly (HP:0001339)2.30879465
53Hypercortisolism (HP:0001578)2.30047791
54Stridor (HP:0010307)2.28945283
55Aplasia/Hypoplasia of the brainstem (HP:0007362)2.27005542
56Hypoplasia of the brainstem (HP:0002365)2.27005542
57Abnormality of calcium-phosphate metabolism (HP:0100530)2.26201831
58Broad metatarsal (HP:0001783)2.23501077
59Hepatoblastoma (HP:0002884)2.23481403
60Pheochromocytoma (HP:0002666)2.23188682
61Progressive cerebellar ataxia (HP:0002073)2.20492277
62Hemiparesis (HP:0001269)2.18945327
63Vertebral arch anomaly (HP:0008438)2.18317350
64Abnormal eating behavior (HP:0100738)2.17793908
65Overriding aorta (HP:0002623)2.17713596
66Abnormality of the distal phalanx of the thumb (HP:0009617)2.17651536
67Truncal ataxia (HP:0002078)2.17435788
68Trigonocephaly (HP:0000243)2.16720602
69Disproportionate tall stature (HP:0001519)2.15635486
70Vertebral compression fractures (HP:0002953)2.15293475
71Abnormality of the fingertips (HP:0001211)2.13367317
72Pointed chin (HP:0000307)2.12247113
73Bladder diverticulum (HP:0000015)2.11658037
74Thin ribs (HP:0000883)2.11427410
75Hand muscle atrophy (HP:0009130)2.10616049
76Lymphangioma (HP:0100764)2.10546776
77Absence seizures (HP:0002121)2.10170526
78Increased connective tissue (HP:0009025)2.08690046
79Asymmetry of the thorax (HP:0001555)2.05867959
80Broad distal phalanx of finger (HP:0009836)2.05825737
81Menstrual irregularities (HP:0000858)2.05084760
82Astrocytoma (HP:0009592)2.04749181
83Abnormality of the astrocytes (HP:0100707)2.04749181
84Cerebral inclusion bodies (HP:0100314)2.03042494
85Renovascular hypertension (HP:0100817)2.01292499
86Bowel diverticulosis (HP:0005222)2.00553702
87Abnormality of dentin (HP:0010299)2.00242787
88Advanced eruption of teeth (HP:0006288)1.98364560
89Ankyloglossia (HP:0010296)1.98146002
90Apathy (HP:0000741)1.97977152
91Difficulty climbing stairs (HP:0003551)1.95744324
92Amblyopia (HP:0000646)1.95739179
93Centrally nucleated skeletal muscle fibers (HP:0003687)1.94932106
94Wormian bones (HP:0002645)1.94793737
95Anxiety (HP:0000739)1.94791117
96Dislocated radial head (HP:0003083)1.94782369
97Flattened epiphyses (HP:0003071)1.93351389
98Sacral dimple (HP:0000960)1.92629163
99Mildly elevated creatine phosphokinase (HP:0008180)1.91750511
100Atrophic scars (HP:0001075)1.91572704
101Hemorrhage of the eye (HP:0011885)1.91369527
102Abnormality of the radial head (HP:0003995)1.89442964
103Atrophy/Degeneration involving motor neurons (HP:0007373)1.89355782
104Urethral obstruction (HP:0000796)1.89025503
105Aneurysm (HP:0002617)1.88534433
106Open mouth (HP:0000194)1.88417222
107Broad palm (HP:0001169)1.87561809
108Lower limb amyotrophy (HP:0007210)1.85488692
109Selective tooth agenesis (HP:0001592)1.84845155
110Torticollis (HP:0000473)1.84760635
111Atonic seizures (HP:0010819)1.84519921
112Abnormality of the thoracic spine (HP:0100711)1.84042603
113Poor eye contact (HP:0000817)1.83971946
114Diminished motivation (HP:0000745)1.83721989
115Narrow nasal bridge (HP:0000446)1.83637777
116Generalized tonic-clonic seizures (HP:0002069)1.83445461
117Myopathic facies (HP:0002058)1.82408742
118Neuroendocrine neoplasm (HP:0100634)1.82293203
119Adducted thumb (HP:0001181)1.81440152
120Abnormality of the calcaneus (HP:0008364)1.80979759
121Achilles tendon contracture (HP:0001771)1.80312756
122Short nail (HP:0001799)1.79810679
123Fragile skin (HP:0001030)1.79689615
124Deformed sella turcica (HP:0002681)1.79637602
125Generalized hypotonia (HP:0001290)1.79161269
126Spastic gait (HP:0002064)1.78284039
127Genetic anticipation (HP:0003743)1.77369635
128Flat cornea (HP:0007720)1.77153995
129Spinal cord lesions (HP:0100561)1.76697356
130Syringomyelia (HP:0003396)1.76697356
131Central scotoma (HP:0000603)1.76325930
132Urinary urgency (HP:0000012)1.76318504
133Enlarged penis (HP:0000040)1.75898525
134Arnold-Chiari malformation (HP:0002308)1.75229143
135Action tremor (HP:0002345)1.75081906
136Patellar dislocation (HP:0002999)1.74548676
137Sporadic (HP:0003745)1.74432369
138Congenital glaucoma (HP:0001087)1.74064367
139Premature skin wrinkling (HP:0100678)1.73031479
140Blue sclerae (HP:0000592)1.72778230
141Spinal rigidity (HP:0003306)1.72442360
142Abnormal social behavior (HP:0012433)1.71643788
143Impaired social interactions (HP:0000735)1.71643788
144Interstitial pulmonary disease (HP:0006530)1.71399599
145Hypoglycemic seizures (HP:0002173)1.71233961
146Akinesia (HP:0002304)1.71202859
147Natal tooth (HP:0000695)1.71052063
148Abnormality of oral frenula (HP:0000190)1.71007674
149Clonus (HP:0002169)1.70448482
150Growth hormone excess (HP:0000845)1.70298016
151Specific learning disability (HP:0001328)1.69610899
152Urinary bladder sphincter dysfunction (HP:0002839)1.69546089
153Bradykinesia (HP:0002067)1.68441359
154Pelvic girdle muscle weakness (HP:0003749)1.68237088
155Germ cell neoplasia (HP:0100728)1.67213432
156Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.66649603
157Absent epiphyses (HP:0010577)1.66649603
158Focal dystonia (HP:0004373)1.66396573
159Megalocornea (HP:0000485)1.66264809
160Neurofibrillary tangles (HP:0002185)1.65530375
161Heterotopia (HP:0002282)1.65457243
162Lower limb muscle weakness (HP:0007340)1.65162792
163Sleep apnea (HP:0010535)1.65037767
164Hammertoe (HP:0001765)1.64770687
165Nuclear cataract (HP:0100018)1.64735423
166Precocious puberty (HP:0000826)1.64086391
167Increased variability in muscle fiber diameter (HP:0003557)1.63337578
168Labial hypoplasia (HP:0000066)1.63167213
169Buphthalmos (HP:0000557)1.62975762
170Dialeptic seizures (HP:0011146)1.62918921
171Obsessive-compulsive behavior (HP:0000722)1.62816499
172Exercise-induced myalgia (HP:0003738)1.62629119
173Hypoplasia of the capital femoral epiphysis (HP:0003090)1.61831419
174Genu recurvatum (HP:0002816)1.61808664
175Gait imbalance (HP:0002141)1.61735111
176Abnormality of the corticospinal tract (HP:0002492)1.61689155
177Hyperparathyroidism (HP:0000843)1.61593480
178Impaired smooth pursuit (HP:0007772)1.61408522
179Long eyelashes (HP:0000527)1.60994416
180Back pain (HP:0003418)1.60671840
181Colitis (HP:0002583)1.59798443
182Joint laxity (HP:0001388)1.58508098
183Abnormality of the Achilles tendon (HP:0005109)1.57622299
184Mitral valve prolapse (HP:0001634)1.56182892
185Joint stiffness (HP:0001387)1.56032153
186Abnormality of the humeroradial joint (HP:0100744)1.56000849
187Atelectasis (HP:0100750)1.55404983
188Camptodactyly of toe (HP:0001836)1.54117285
189Dilatation of the ascending aorta (HP:0005111)1.53328768
190Aortic regurgitation (HP:0001659)1.53146167

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.85434984
2SMG13.75395578
3MAP3K93.58532277
4SIK13.24535940
5FGFR42.85322821
6NTRK32.83980986
7CDK122.82628987
8NTRK22.75000727
9MINK12.70140127
10MAP3K42.65357014
11PRPF4B2.47687169
12ERN12.30237761
13PRKD32.26022683
14UHMK12.23697760
15KSR12.22230145
16PAK62.18366052
17EPHA21.96957466
18NTRK11.82805346
19MAPK131.77816321
20TTN1.72423730
21PASK1.72049524
22WNK31.67738451
23PHKG11.66523981
24PHKG21.66523981
25LATS21.64919904
26DYRK21.64227377
27ERBB31.63299957
28EPHB11.60839665
29MAP2K71.59844899
30SIK21.56063682
31SCYL21.55060874
32PDGFRA1.50389689
33KSR21.46731066
34PRKD21.44300575
35TYRO31.39884255
36PAK31.39746324
37CDK51.29636863
38CSNK1G21.25380164
39TRIB31.23997002
40CAMKK11.22874927
41EEF2K1.22346858
42TNK21.16567400
43MAP2K31.16362545
44PAK41.15343583
45PNCK1.15139612
46MAP2K41.14406809
47MAP3K21.12503910
48RET1.12312857
49INSRR1.11684036
50MAP3K61.08900862
51MAP3K71.07247316
52MST1R1.07223990
53DAPK21.05064626
54ICK1.04809545
55CSNK1G31.02492295
56ALK1.01366478
57CDK181.01306962
58CDK140.99092086
59EPHB20.97065674
60BRD40.96834645
61CDK150.96210923
62DYRK1A0.95117076
63BCR0.94873812
64HIPK20.94655634
65LIMK10.94358920
66BMX0.94198720
67MET0.93039571
68CAMK1G0.92631304
69NEK10.92128155
70MAP4K10.90984897
71FGFR30.88396210
72FER0.87877632
73CDK11A0.87085139
74MARK20.85476634
75MAPK150.85226668
76SIK30.84952071
77MAP3K130.84585171
78PKN20.82851354
79PRKCH0.80856062
80CDC42BPA0.80393186
81RPS6KA20.79895351
82MAP3K100.78651645
83CDK40.78129928
84CSNK1A1L0.75862364
85MAP3K120.75165938
86PRKCG0.74849987
87DYRK1B0.74659050
88LMTK20.73839525
89DDR20.73432239
90FGFR20.72846743
91CDK90.72574029
92IRAK30.71314334
93RPS6KL10.71034817
94RPS6KC10.71034817
95CDK60.68714224
96PTK60.67334111
97TNIK0.66331367
98PDGFRB0.66061585
99STK380.65934156
100DAPK10.65926100
101CDK70.65872997
102RIPK10.65839086
103BRSK10.65734995
104ERBB20.65406339
105MAP2K20.65111255
106TAOK10.61751494
107CSNK1G10.61112722
108MAPK110.61106367
109PTK20.60030870
110PLK20.58981397
111GRK50.58648717
112MAPK90.56241509
113PAK20.55794054
114EPHA30.55460407
115PRKCZ0.55048159
116CDK190.54709984
117PDPK10.50739713
118STK110.50192861
119TBK10.49438875
120MAP2K60.47526102
121FGFR10.46570581
122EPHA40.45234261
123IRAK20.45157045
124LRRK20.45111689
125TESK20.44754417
126JAK30.44127107
127RPS6KA60.43982911
128NME20.42714997
129ZAP700.42294045
130MAP3K140.42206692
131MAPK100.41762212
132CAMKK20.40447591
133MTOR0.39893886
134CSNK1E0.38954262
135RPS6KA30.38836803
136ROCK20.38415947
137TESK10.37830510
138MAPK120.37251734
139RPS6KB20.36555810
140FYN0.36150557
141PRKAA10.36132057
142MAPK70.35306887
143CAMK1D0.34574041
144GSK3B0.33913298
145ADRBK10.33251968
146MAPK80.33088702
147PLK30.32980856
148RPS6KA10.32953133
149CAMK2A0.32632014
150MAPKAPK20.32443572
151NEK60.32201143
152AKT20.32130397
153MAP3K80.31940760
154MAP3K10.30990246
155CDK20.30953239
156PRKD10.29987269
157TYK20.28361948
158NEK90.28090130
159JAK10.27898622

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.97698781
2Other glycan degradation_Homo sapiens_hsa005112.95413961
3Nicotine addiction_Homo sapiens_hsa050332.63980462
4GABAergic synapse_Homo sapiens_hsa047272.51931298
5Insulin secretion_Homo sapiens_hsa049112.43057367
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.41670274
7Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.35149002
8Circadian entrainment_Homo sapiens_hsa047132.14075760
9Dopaminergic synapse_Homo sapiens_hsa047282.08467087
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.00641561
11Cocaine addiction_Homo sapiens_hsa050302.00314702
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.94826960
13Morphine addiction_Homo sapiens_hsa050321.91271004
14Amphetamine addiction_Homo sapiens_hsa050311.88083925
15Cholinergic synapse_Homo sapiens_hsa047251.79060154
16Long-term potentiation_Homo sapiens_hsa047201.78118609
17Olfactory transduction_Homo sapiens_hsa047401.77514519
18Type II diabetes mellitus_Homo sapiens_hsa049301.76839895
19Lysine degradation_Homo sapiens_hsa003101.74577281
20Glutamatergic synapse_Homo sapiens_hsa047241.72661923
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.69500220
22Acute myeloid leukemia_Homo sapiens_hsa052211.68883955
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.65626431
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60564611
25Axon guidance_Homo sapiens_hsa043601.59449087
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54515685
27Gap junction_Homo sapiens_hsa045401.54203227
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51640493
29Biosynthesis of amino acids_Homo sapiens_hsa012301.45728908
30Estrogen signaling pathway_Homo sapiens_hsa049151.41678185
31Fructose and mannose metabolism_Homo sapiens_hsa000511.41527433
32Taste transduction_Homo sapiens_hsa047421.39428809
33Serotonergic synapse_Homo sapiens_hsa047261.38590051
34Vibrio cholerae infection_Homo sapiens_hsa051101.34308197
35Thyroid cancer_Homo sapiens_hsa052161.34283584
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32375050
37Pentose phosphate pathway_Homo sapiens_hsa000301.31922335
38Renin secretion_Homo sapiens_hsa049241.30690603
39Melanogenesis_Homo sapiens_hsa049161.30134987
40Gastric acid secretion_Homo sapiens_hsa049711.29660732
41Endometrial cancer_Homo sapiens_hsa052131.27908052
42Focal adhesion_Homo sapiens_hsa045101.27411728
43Salivary secretion_Homo sapiens_hsa049701.26441644
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25639728
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.25050332
46Small cell lung cancer_Homo sapiens_hsa052221.23172079
47Pancreatic cancer_Homo sapiens_hsa052121.22660098
48Oxytocin signaling pathway_Homo sapiens_hsa049211.22059673
49Colorectal cancer_Homo sapiens_hsa052101.21864110
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21611453
51GnRH signaling pathway_Homo sapiens_hsa049121.19860893
52Glioma_Homo sapiens_hsa052141.16941566
53Alcoholism_Homo sapiens_hsa050341.16888780
54Long-term depression_Homo sapiens_hsa047301.15151194
55Oocyte meiosis_Homo sapiens_hsa041141.14558670
56ECM-receptor interaction_Homo sapiens_hsa045121.14402299
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12055295
58Inositol phosphate metabolism_Homo sapiens_hsa005621.09792989
59MicroRNAs in cancer_Homo sapiens_hsa052061.08077930
60Prostate cancer_Homo sapiens_hsa052151.07864095
61Hedgehog signaling pathway_Homo sapiens_hsa043401.07435396
62Adherens junction_Homo sapiens_hsa045201.06830441
63ErbB signaling pathway_Homo sapiens_hsa040121.06772016
64Neurotrophin signaling pathway_Homo sapiens_hsa047221.06486792
65N-Glycan biosynthesis_Homo sapiens_hsa005101.05121379
66Basal cell carcinoma_Homo sapiens_hsa052171.04988648
67Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04446357
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03539075
69Wnt signaling pathway_Homo sapiens_hsa043100.99586984
70Phototransduction_Homo sapiens_hsa047440.98113438
71mTOR signaling pathway_Homo sapiens_hsa041500.97812863
72Proteoglycans in cancer_Homo sapiens_hsa052050.97264741
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95761689
74Hippo signaling pathway_Homo sapiens_hsa043900.95246992
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94924643
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94214196
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93330975
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91187327
79B cell receptor signaling pathway_Homo sapiens_hsa046620.90177953
80cAMP signaling pathway_Homo sapiens_hsa040240.89198180
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.89107207
82Glucagon signaling pathway_Homo sapiens_hsa049220.88071400
83Renal cell carcinoma_Homo sapiens_hsa052110.87003313
84Insulin signaling pathway_Homo sapiens_hsa049100.86193808
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84687137
86Thyroid hormone synthesis_Homo sapiens_hsa049180.81374466
87Hepatitis C_Homo sapiens_hsa051600.81347115
88Type I diabetes mellitus_Homo sapiens_hsa049400.81197263
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80280072
90Calcium signaling pathway_Homo sapiens_hsa040200.80273479
91Galactose metabolism_Homo sapiens_hsa000520.78639893
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78454646
93Collecting duct acid secretion_Homo sapiens_hsa049660.77605858
94Insulin resistance_Homo sapiens_hsa049310.77216585
95Hepatitis B_Homo sapiens_hsa051610.77165554
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.74485581
97HTLV-I infection_Homo sapiens_hsa051660.74371594
98Carbon metabolism_Homo sapiens_hsa012000.74030665
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73458450
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.71761549
101Viral carcinogenesis_Homo sapiens_hsa052030.71681874
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70424458
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70094562
104Base excision repair_Homo sapiens_hsa034100.70004072
105Prolactin signaling pathway_Homo sapiens_hsa049170.69312147
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69229177
107Prion diseases_Homo sapiens_hsa050200.67514397
108Non-small cell lung cancer_Homo sapiens_hsa052230.66899990
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.66507154
110Dilated cardiomyopathy_Homo sapiens_hsa054140.65885676
111Circadian rhythm_Homo sapiens_hsa047100.65485120
112Amoebiasis_Homo sapiens_hsa051460.64777731
113Chronic myeloid leukemia_Homo sapiens_hsa052200.63764540
114Apoptosis_Homo sapiens_hsa042100.63051586
115Dorso-ventral axis formation_Homo sapiens_hsa043200.62751059
116Spliceosome_Homo sapiens_hsa030400.62687831
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62589289
118MAPK signaling pathway_Homo sapiens_hsa040100.62234588
119VEGF signaling pathway_Homo sapiens_hsa043700.61175966
120Pathways in cancer_Homo sapiens_hsa052000.61014890
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60363072
122Pancreatic secretion_Homo sapiens_hsa049720.59417371
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.58957168
124Endocytosis_Homo sapiens_hsa041440.58047125
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57674216
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57525194
127mRNA surveillance pathway_Homo sapiens_hsa030150.56550859
128Toxoplasmosis_Homo sapiens_hsa051450.56412489
129AMPK signaling pathway_Homo sapiens_hsa041520.55689153
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54469042
131Notch signaling pathway_Homo sapiens_hsa043300.54396184
132Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54004738
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53726367
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53514789
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.53348273
136Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53339792
137Choline metabolism in cancer_Homo sapiens_hsa052310.53122452
138Bile secretion_Homo sapiens_hsa049760.52587325
139Cardiac muscle contraction_Homo sapiens_hsa042600.49841576
140Ras signaling pathway_Homo sapiens_hsa040140.48981949
141Influenza A_Homo sapiens_hsa051640.48661760
142T cell receptor signaling pathway_Homo sapiens_hsa046600.48141086
143Rap1 signaling pathway_Homo sapiens_hsa040150.48080122
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45537619
145Tight junction_Homo sapiens_hsa045300.45371323
146Bladder cancer_Homo sapiens_hsa052190.44959594
147Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44296964

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