WDR60

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) and may facilitate the formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. The encoded protein contains four WD repeats and may play a role in the formation of cilia. Mutations in this gene have been associated with short-rib polydactyly and Jeune syndromes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)8.77867789
2axonemal dynein complex assembly (GO:0070286)8.60768162
3epithelial cilium movement (GO:0003351)7.56487084
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.06196349
5axoneme assembly (GO:0035082)6.74652312
6motile cilium assembly (GO:0044458)6.02464961
7acrosome assembly (GO:0001675)5.79803573
8ventricular system development (GO:0021591)5.54966590
9intraciliary transport (GO:0042073)5.50836323
10sperm motility (GO:0030317)5.22872780
11regulation of cilium movement (GO:0003352)5.19636728
12multicellular organism reproduction (GO:0032504)5.07474823
13fusion of sperm to egg plasma membrane (GO:0007342)5.01406473
14acrosome reaction (GO:0007340)4.96595985
15piRNA metabolic process (GO:0034587)4.74519084
16sperm-egg recognition (GO:0035036)4.62427176
17microtubule depolymerization (GO:0007019)4.46263673
18left/right axis specification (GO:0070986)4.45562520
19male meiosis (GO:0007140)4.41267599
20DNA methylation involved in gamete generation (GO:0043046)4.22245731
21cilium organization (GO:0044782)4.13377850
22cell-cell recognition (GO:0009988)4.02737130
23cilium assembly (GO:0042384)4.01376669
24limb bud formation (GO:0060174)3.99524867
25binding of sperm to zona pellucida (GO:0007339)3.95698977
26plasma membrane fusion (GO:0045026)3.94586327
27embryonic body morphogenesis (GO:0010172)3.92058812
28spermatid development (GO:0007286)3.90419179
29synaptonemal complex organization (GO:0070193)3.88847801
30cell wall macromolecule metabolic process (GO:0044036)3.84131615
31cell wall macromolecule catabolic process (GO:0016998)3.84131615
32reproduction (GO:0000003)3.81038877
33single fertilization (GO:0007338)3.78373403
34GTP biosynthetic process (GO:0006183)3.67737345
35substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.64767936
36substrate-independent telencephalic tangential migration (GO:0021826)3.64767936
37microtubule severing (GO:0051013)3.62599001
38protein polyglutamylation (GO:0018095)3.60538705
39cilium morphogenesis (GO:0060271)3.59700977
40cellular component assembly involved in morphogenesis (GO:0010927)3.58401561
41centriole replication (GO:0007099)3.54579292
42nonmotile primary cilium assembly (GO:0035058)3.46540637
43body morphogenesis (GO:0010171)3.43405129
44microtubule bundle formation (GO:0001578)3.43012081
45centriole assembly (GO:0098534)3.42804301
46retinal rod cell development (GO:0046548)3.39628702
47male meiosis I (GO:0007141)3.38984006
48nucleoside diphosphate phosphorylation (GO:0006165)3.37975736
49lateral sprouting from an epithelium (GO:0060601)3.33236851
50microtubule-based movement (GO:0007018)3.30821722
51auditory receptor cell differentiation (GO:0042491)3.30552692
52negative regulation of inclusion body assembly (GO:0090084)3.28912224
53sperm capacitation (GO:0048240)3.26602007
54synaptonemal complex assembly (GO:0007130)3.22822053
55limb development (GO:0060173)3.14868276
56appendage development (GO:0048736)3.14868276
57protein localization to cilium (GO:0061512)3.14094644
58photoreceptor cell maintenance (GO:0045494)3.13436715
59fertilization (GO:0009566)3.12899829
60microtubule polymerization or depolymerization (GO:0031109)3.07538860
61otic vesicle formation (GO:0030916)3.06689905
62synaptic vesicle docking involved in exocytosis (GO:0016081)3.06567295
63one-carbon compound transport (GO:0019755)3.03245314
64spermatid nucleus differentiation (GO:0007289)3.02848938
65UTP biosynthetic process (GO:0006228)3.02720709
66UTP metabolic process (GO:0046051)3.02222446
67calcium ion-dependent exocytosis (GO:0017156)2.96580296
68peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.95714367
69phosphorelay signal transduction system (GO:0000160)2.89379341
70postsynaptic membrane organization (GO:0001941)2.87854260
71photoreceptor cell differentiation (GO:0046530)2.85026744
72eye photoreceptor cell differentiation (GO:0001754)2.85026744
73left/right pattern formation (GO:0060972)2.83999306
74nephron tubule morphogenesis (GO:0072078)2.81147124
75nephron epithelium morphogenesis (GO:0072088)2.81147124
76atrial cardiac muscle cell action potential (GO:0086014)2.80476177
77regulation of inclusion body assembly (GO:0090083)2.78046687
78protein localization to synapse (GO:0035418)2.77334286
79cellular response to ATP (GO:0071318)2.76703218
80eye photoreceptor cell development (GO:0042462)2.76618630
81axon ensheathment in central nervous system (GO:0032291)2.76246906
82central nervous system myelination (GO:0022010)2.76246906
83photoreceptor cell development (GO:0042461)2.75612437
84axonal fasciculation (GO:0007413)2.75166736
85cell recognition (GO:0008037)2.74213074
86regulation of rhodopsin mediated signaling pathway (GO:0022400)2.72567821
87neuronal ion channel clustering (GO:0045161)2.71501096
88rhodopsin mediated signaling pathway (GO:0016056)2.71091185
89negative regulation of transcription regulatory region DNA binding (GO:2000678)2.70631396
90somite development (GO:0061053)2.69106413
91behavioral response to nicotine (GO:0035095)2.68789165
92pattern specification involved in kidney development (GO:0061004)2.68658776
93regulation of microtubule-based movement (GO:0060632)2.67709504
94spermatogenesis (GO:0007283)2.66979873
95presynaptic membrane assembly (GO:0097105)2.66641686
96cell projection assembly (GO:0030031)2.66518640
97transmission of nerve impulse (GO:0019226)2.65830900
98male gamete generation (GO:0048232)2.65500481
99calcium ion import (GO:0070509)2.62426898
100positive regulation of meiosis (GO:0045836)2.60968957
101neural crest cell development (GO:0014032)2.60860696
102neuron fate determination (GO:0048664)2.60532546
103membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.60368765
104pyrimidine nucleobase catabolic process (GO:0006208)2.59088226
105regulation of short-term neuronal synaptic plasticity (GO:0048172)2.57433962
106negative regulation of appetite (GO:0032099)2.57297554
107negative regulation of response to food (GO:0032096)2.57297554
108neuronal stem cell maintenance (GO:0097150)2.55952212
109cell proliferation in forebrain (GO:0021846)2.54858501
110regulation of pigment cell differentiation (GO:0050932)2.53905644
111cellular response to gamma radiation (GO:0071480)2.53309516
112smoothened signaling pathway (GO:0007224)2.52625705
113neuron cell-cell adhesion (GO:0007158)2.50252946
114gamete generation (GO:0007276)2.48970263
115activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.48432032
116telencephalon development (GO:0021537)2.48407660
117cranial nerve morphogenesis (GO:0021602)2.47369652
118camera-type eye morphogenesis (GO:0048593)2.47282568
119presynaptic membrane organization (GO:0097090)2.47158780
120positive regulation of fibroblast migration (GO:0010763)2.46812319
121mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.46660179
122regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.46465892
123histone H3-K4 trimethylation (GO:0080182)2.46017461
124positive regulation of meiotic cell cycle (GO:0051446)2.45360491
125response to pheromone (GO:0019236)2.43369589
126cerebral cortex radially oriented cell migration (GO:0021799)2.41163932
127spinal cord development (GO:0021510)2.39271219
128neuron recognition (GO:0008038)2.38880953
129dendritic spine morphogenesis (GO:0060997)2.37395400
130response to misfolded protein (GO:0051788)2.36820671
131inner ear receptor cell differentiation (GO:0060113)2.35308852
132neurotransmitter-gated ion channel clustering (GO:0072578)2.33344962
133negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.33304181
134regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.32847437
135urogenital system development (GO:0001655)2.31554634
136negative regulation of astrocyte differentiation (GO:0048712)2.29970846
137hair cell differentiation (GO:0035315)2.29003685
138cell differentiation in spinal cord (GO:0021515)2.26033648
139spinal cord motor neuron differentiation (GO:0021522)2.25839149
140tongue development (GO:0043586)2.25726306
141retinal ganglion cell axon guidance (GO:0031290)2.24276209
142establishment of mitochondrion localization (GO:0051654)2.24030906
143short-term memory (GO:0007614)2.23819303
144determination of left/right symmetry (GO:0007368)2.20568173
145auditory behavior (GO:0031223)2.19308463
146viral transcription (GO:0019083)2.19069875
147brain morphogenesis (GO:0048854)2.18680915
148mechanosensory behavior (GO:0007638)2.18505556
149gamma-aminobutyric acid transport (GO:0015812)2.17760700
150G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.17429194
151mechanoreceptor differentiation (GO:0042490)2.16825351
152positive regulation of gastrulation (GO:2000543)2.15831009
153cornea development in camera-type eye (GO:0061303)2.15075787
154olfactory bulb development (GO:0021772)2.14826884
155establishment of protein localization to Golgi (GO:0072600)2.14005333
156cell migration in hindbrain (GO:0021535)2.13354007
157translational termination (GO:0006415)2.13247527
158nucleobase catabolic process (GO:0046113)2.12073731
159cilium or flagellum-dependent cell motility (GO:0001539)10.1128972

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.07560708
2GBX2_23144817_ChIP-Seq_PC3_Human3.78066361
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.59409639
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.75569100
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69668684
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43129803
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18785669
8CBX2_27304074_Chip-Seq_ESCs_Mouse2.17607192
9CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98687001
10RNF2_27304074_Chip-Seq_NSC_Mouse1.94789574
11BMI1_23680149_ChIP-Seq_NPCS_Mouse1.90325223
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.89096388
13POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89093259
14PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88692453
15TAF15_26573619_Chip-Seq_HEK293_Human1.88073100
16FUS_26573619_Chip-Seq_HEK293_Human1.85867877
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84151623
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.81289947
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76328719
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.75959408
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74712557
22GATA1_26923725_Chip-Seq_HPCs_Mouse1.74563515
23P300_19829295_ChIP-Seq_ESCs_Human1.73453295
24VDR_22108803_ChIP-Seq_LS180_Human1.71815116
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71532773
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69135147
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.68459723
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.67444543
29SMAD4_21799915_ChIP-Seq_A2780_Human1.67094316
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.65903252
31TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.64218870
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62595068
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.61434803
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60063059
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60063059
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.59990419
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.59862615
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59792086
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59235602
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54054569
41* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52556072
42NANOG_18555785_Chip-Seq_ESCs_Mouse1.51592600
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50875472
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.49640877
45IGF1R_20145208_ChIP-Seq_DFB_Human1.49444073
46ER_23166858_ChIP-Seq_MCF-7_Human1.47184126
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.45655002
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.44293710
49EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.43250366
50SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43147448
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.42360253
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.42116525
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.41780908
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41780104
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41206333
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41199596
57ZNF274_21170338_ChIP-Seq_K562_Hela1.40756329
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38946110
59MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38165739
60CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.38041868
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.37948747
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37122499
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36422343
64TCF4_23295773_ChIP-Seq_U87_Human1.35757639
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34383782
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.34074428
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33030277
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32432834
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32337674
70BCAT_22108803_ChIP-Seq_LS180_Human1.31670214
71P53_22387025_ChIP-Seq_ESCs_Mouse1.31066788
72STAT3_23295773_ChIP-Seq_U87_Human1.31044504
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.30971576
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29732073
75* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29268995
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28268528
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.28139935
78AR_21572438_ChIP-Seq_LNCaP_Human1.27606405
79SUZ12_18555785_Chip-Seq_ESCs_Mouse1.27311212
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27292157
81CMYC_18555785_Chip-Seq_ESCs_Mouse1.26110140
82REST_21632747_ChIP-Seq_MESCs_Mouse1.25504043
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25421993
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25421993
85TAL1_26923725_Chip-Seq_HPCs_Mouse1.25053753
86P300_18555785_Chip-Seq_ESCs_Mouse1.23884520
87EWS_26573619_Chip-Seq_HEK293_Human1.23752519
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23309993
89REST_18959480_ChIP-ChIP_MESCs_Mouse1.23209140
90CBP_20019798_ChIP-Seq_JUKART_Human1.23141154
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23141154
92DROSHA_22980978_ChIP-Seq_HELA_Human1.22903658
93AHR_22903824_ChIP-Seq_MCF-7_Human1.22541762
94EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.22469645
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.22330707
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21453182
97STAT3_18555785_Chip-Seq_ESCs_Mouse1.19708209
98AR_25329375_ChIP-Seq_VCAP_Human1.19217742
99* SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.18906654
100TP53_18474530_ChIP-ChIP_U2OS_Human1.18382082
101KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16498276
102* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15640293
103OCT4_18555785_Chip-Seq_ESCs_Mouse1.15254712
104CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15181338
105ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14744607
106* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13981105
107NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12633858
108* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12561071
109RING1B_27294783_Chip-Seq_ESCs_Mouse1.12536298
110KLF4_18555785_Chip-Seq_ESCs_Mouse1.12248549
111ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12082257
112SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11191178
113RUNX2_22187159_ChIP-Seq_PCA_Human1.10344965
114SMAD3_21741376_ChIP-Seq_ESCs_Human1.09387545
115MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06817758
116E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06797966
117KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04766007
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04140561
119EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04008149
120* WDR5_24793694_ChIP-Seq_LNCAP_Human1.03507774
121HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02916107
122TBL1_22424771_ChIP-Seq_293T_Human1.01456767
123RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01138546
124CTCF_27219007_Chip-Seq_Bcells_Human1.00740822
125SOX2_21211035_ChIP-Seq_LN229_Gbm0.97564163
126AR_19668381_ChIP-Seq_PC3_Human0.97430412
127IRF1_19129219_ChIP-ChIP_H3396_Human0.97212665
128SMAD4_21741376_ChIP-Seq_EPCs_Human0.96871065
129E2F1_17053090_ChIP-ChIP_MCF-7_Human0.95645859
130ERA_21632823_ChIP-Seq_H3396_Human0.92853704
131JUN_21703547_ChIP-Seq_K562_Human0.90919510
132RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90443341
133OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89898879
134TP63_19390658_ChIP-ChIP_HaCaT_Human0.89556013
135TCF4_22108803_ChIP-Seq_LS180_Human0.88308668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.48397599
2MP0008877_abnormal_DNA_methylation2.95463593
3MP0004859_abnormal_synaptic_plasticity2.62583247
4MP0005551_abnormal_eye_electrophysiolog2.61428856
5MP0001984_abnormal_olfaction2.48361168
6MP0003787_abnormal_imprinting2.37309807
7MP0002653_abnormal_ependyma_morphology2.32857393
8MP0003880_abnormal_central_pattern2.30228037
9MP0009379_abnormal_foot_pigmentation2.27713109
10MP0003698_abnormal_male_reproductive2.24031033
11MP0005646_abnormal_pituitary_gland2.06262281
12MP0005409_darkened_coat_color2.05897901
13MP0001188_hyperpigmentation2.04280217
14MP0003136_yellow_coat_color2.01497249
15MP0005623_abnormal_meninges_morphology2.01124981
16MP0009046_muscle_twitch1.99998301
17MP0008789_abnormal_olfactory_epithelium1.98420931
18MP0004145_abnormal_muscle_electrophysio1.94782047
19MP0004134_abnormal_chest_morphology1.91390350
20MP0003123_paternal_imprinting1.85378437
21MP0005499_abnormal_olfactory_system1.84717820
22MP0005394_taste/olfaction_phenotype1.84717820
23MP0001929_abnormal_gametogenesis1.80970470
24MP0006292_abnormal_olfactory_placode1.79899782
25MP0005503_abnormal_tendon_morphology1.72702676
26MP0005171_absent_coat_pigmentation1.69500711
27MP0001485_abnormal_pinna_reflex1.68618630
28MP0002234_abnormal_pharynx_morphology1.67619685
29MP0002249_abnormal_larynx_morphology1.66173988
30MP0006072_abnormal_retinal_apoptosis1.63474187
31MP0009250_abnormal_appendicular_skeleto1.63433545
32MP0003635_abnormal_synaptic_transmissio1.62212687
33MP0009697_abnormal_copulation1.59773896
34MP0004043_abnormal_pH_regulation1.59090748
35MP0004270_analgesia1.57610447
36MP0005253_abnormal_eye_physiology1.56187862
37MP0009745_abnormal_behavioral_response1.53335531
38MP0002102_abnormal_ear_morphology1.52266342
39MP0001486_abnormal_startle_reflex1.50402636
40MP0000566_synostosis1.49614470
41MP0002160_abnormal_reproductive_system1.48492857
42MP0005377_hearing/vestibular/ear_phenot1.48398153
43MP0003878_abnormal_ear_physiology1.48398153
44MP0008995_early_reproductive_senescence1.48381690
45MP0002210_abnormal_sex_determination1.47697930
46MP0002233_abnormal_nose_morphology1.46814332
47MP0000049_abnormal_middle_ear1.46472287
48MP0002282_abnormal_trachea_morphology1.42149826
49MP0000778_abnormal_nervous_system1.41983309
50MP0002272_abnormal_nervous_system1.41767673
51MP0005645_abnormal_hypothalamus_physiol1.39295491
52MP0003950_abnormal_plasma_membrane1.37904805
53MP0002909_abnormal_adrenal_gland1.35271982
54MP0009780_abnormal_chondrocyte_physiolo1.29842270
55MP0002063_abnormal_learning/memory/cond1.29611964
56MP0000955_abnormal_spinal_cord1.27641070
57MP0002734_abnormal_mechanical_nocicepti1.26633963
58MP0002938_white_spotting1.26162745
59MP0002572_abnormal_emotion/affect_behav1.24704149
60MP0001440_abnormal_grooming_behavior1.23241770
61MP0002064_seizures1.22311010
62MP0010030_abnormal_orbit_morphology1.22206169
63MP0005195_abnormal_posterior_eye1.20787945
64MP0000631_abnormal_neuroendocrine_gland1.19792247
65MP0002184_abnormal_innervation1.18065531
66MP0006276_abnormal_autonomic_nervous1.17528854
67MP0003861_abnormal_nervous_system1.17188591
68MP0004885_abnormal_endolymph1.15296239
69MP0000383_abnormal_hair_follicle1.13856096
70MP0000653_abnormal_sex_gland1.13809412
71MP0001905_abnormal_dopamine_level1.13294067
72MP0001145_abnormal_male_reproductive1.13267621
73MP0003119_abnormal_digestive_system1.12663593
74MP0002557_abnormal_social/conspecific_i1.11036411
75MP0003942_abnormal_urinary_system1.08588005
76MP0005423_abnormal_somatic_nervous1.08448438
77MP0002752_abnormal_somatic_nervous1.08387040
78MP0003385_abnormal_body_wall1.07877893
79MP0002116_abnormal_craniofacial_bone1.07668810
80MP0001324_abnormal_eye_pigmentation1.05999034
81MP0002161_abnormal_fertility/fecundity1.05813322
82MP0005391_vision/eye_phenotype1.04727187
83MP0000678_abnormal_parathyroid_gland1.04435217
84MP0003755_abnormal_palate_morphology1.03482283
85MP0002735_abnormal_chemical_nociception1.02669576
86MP0001293_anophthalmia1.02402139
87MP0001501_abnormal_sleep_pattern1.02055184
88MP0000372_irregular_coat_pigmentation1.01834050
89MP0001177_atelectasis1.01227508
90MP0001970_abnormal_pain_threshold1.00772670
91MP0003122_maternal_imprinting0.99585122
92MP0003937_abnormal_limbs/digits/tail_de0.98929643
93MP0002882_abnormal_neuron_morphology0.98652991
94MP0001502_abnormal_circadian_rhythm0.98243028
95MP0003890_abnormal_embryonic-extraembry0.97809507
96MP0008875_abnormal_xenobiotic_pharmacok0.96338204
97MP0001529_abnormal_vocalization0.94956255
98MP0003938_abnormal_ear_development0.94522519
99MP0002067_abnormal_sensory_capabilities0.93872429
100MP0000534_abnormal_ureter_morphology0.93452948
101MP0001299_abnormal_eye_distance/0.92522420
102MP0008775_abnormal_heart_ventricle0.91863207
103MP0002638_abnormal_pupillary_reflex0.91760056
104MP0000762_abnormal_tongue_morphology0.91612684
105MP0001968_abnormal_touch/_nociception0.90892438
106MP0008438_abnormal_cutaneous_collagen0.90612895
107MP0002108_abnormal_muscle_morphology0.89387287
108MP0000026_abnormal_inner_ear0.87924421
109MP0002109_abnormal_limb_morphology0.87377947
110MP0002751_abnormal_autonomic_nervous0.87246714
111MP0001963_abnormal_hearing_physiology0.86519824
112MP0001286_abnormal_eye_development0.86162679
113MP0003646_muscle_fatigue0.85484043
114MP0008004_abnormal_stomach_pH0.84912749
115MP0003121_genomic_imprinting0.84386303
116MP0004742_abnormal_vestibular_system0.83600897
117MP0004811_abnormal_neuron_physiology0.82543933
118MP0002736_abnormal_nociception_after0.82538143
119MP0002095_abnormal_skin_pigmentation0.82293085
120MP0000432_abnormal_head_morphology0.80836166
121MP0008057_abnormal_DNA_replication0.80620648
122MP0002837_dystrophic_cardiac_calcinosis0.79996561
123MP0004085_abnormal_heartbeat0.79089328
124MP0005389_reproductive_system_phenotype0.78827624
125MP0002229_neurodegeneration0.78787796
126MP0002733_abnormal_thermal_nociception0.78423150
127MP0004133_heterotaxia0.78394235
128MP0002152_abnormal_brain_morphology0.76778379
129MP0001346_abnormal_lacrimal_gland0.76315308
130MP0004142_abnormal_muscle_tone0.75129058
131MP0000751_myopathy0.74997484

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.92332265
2Abnormal respiratory motile cilium physiology (HP:0012261)8.50823787
3Abnormal ciliary motility (HP:0012262)7.76998760
4Absent/shortened dynein arms (HP:0200106)7.40354234
5Dynein arm defect of respiratory motile cilia (HP:0012255)7.40354234
6Rhinitis (HP:0012384)6.76084351
7Abnormal respiratory epithelium morphology (HP:0012253)6.43871740
8Abnormal respiratory motile cilium morphology (HP:0005938)6.43871740
9Chronic bronchitis (HP:0004469)4.35424965
10Nephronophthisis (HP:0000090)4.12992557
11Abnormality of midbrain morphology (HP:0002418)3.96630951
12Molar tooth sign on MRI (HP:0002419)3.96630951
13Chronic hepatic failure (HP:0100626)3.82611474
14Medial flaring of the eyebrow (HP:0010747)3.45267396
15* Pancreatic fibrosis (HP:0100732)3.37531754
16True hermaphroditism (HP:0010459)3.36901542
17Abnormality of the renal medulla (HP:0100957)3.32655961
18Bronchiectasis (HP:0002110)3.25055033
19Aplasia involving bones of the extremities (HP:0009825)3.01287692
20Aplasia involving bones of the upper limbs (HP:0009823)3.01287692
21Aplasia of the phalanges of the hand (HP:0009802)3.01287692
22Central scotoma (HP:0000603)3.00275115
23Gait imbalance (HP:0002141)2.95365044
24Congenital primary aphakia (HP:0007707)2.91871847
25Infertility (HP:0000789)2.81846445
26Aplasia/Hypoplasia of the tongue (HP:0010295)2.74624374
27Tubulointerstitial nephritis (HP:0001970)2.72968497
28Dyschromatopsia (HP:0007641)2.69786821
29Nephrogenic diabetes insipidus (HP:0009806)2.66469637
30Genital tract atresia (HP:0001827)2.61409883
31Myokymia (HP:0002411)2.57268895
32Occipital encephalocele (HP:0002085)2.53246579
33* Postaxial foot polydactyly (HP:0001830)2.51028326
34Abnormality of dentin (HP:0010299)2.50780345
35Bony spicule pigmentary retinopathy (HP:0007737)2.48017587
36Vaginal atresia (HP:0000148)2.45085836
37Decreased central vision (HP:0007663)2.43285493
38Abnormality of the diencephalon (HP:0010662)2.40195371
39Bell-shaped thorax (HP:0001591)2.39471809
40Tubular atrophy (HP:0000092)2.35940622
41Poor coordination (HP:0002370)2.34167921
42Pancreatic cysts (HP:0001737)2.32099648
43* Congenital hepatic fibrosis (HP:0002612)2.27317880
44Hyperventilation (HP:0002883)2.25387351
45Bifid tongue (HP:0010297)2.22866518
46Aplasia/Hypoplasia of the fibula (HP:0006492)2.21905576
47Fibular hypoplasia (HP:0003038)2.20030917
48Microglossia (HP:0000171)2.17575800
49Cystic liver disease (HP:0006706)2.17218833
50Oligodactyly (hands) (HP:0001180)2.16158048
51* Postaxial hand polydactyly (HP:0001162)2.12905335
52Vitreoretinal degeneration (HP:0000655)2.12530354
53Type II lissencephaly (HP:0007260)2.11592669
54* Preaxial hand polydactyly (HP:0001177)2.08023915
55Rib fusion (HP:0000902)2.05934492
56Facial hemangioma (HP:0000329)2.03570855
57Retinal dysplasia (HP:0007973)2.01403250
58Anophthalmia (HP:0000528)2.00832651
59Aplasia/Hypoplasia of the lens (HP:0008063)2.00757197
60Polydipsia (HP:0001959)2.00012464
61Abnormal drinking behavior (HP:0030082)2.00012464
62Lip pit (HP:0100267)1.99826818
63Abnormality of macular pigmentation (HP:0008002)1.99229946
64Aganglionic megacolon (HP:0002251)1.98722720
65Homocystinuria (HP:0002156)1.97379485
66Abnormality of homocysteine metabolism (HP:0010919)1.97379485
67Progressive cerebellar ataxia (HP:0002073)1.97104000
68Narrow forehead (HP:0000341)1.96907378
69* Median cleft lip (HP:0000161)1.96139949
70Abnormality of incisor morphology (HP:0011063)1.96033247
71Chronic sinusitis (HP:0011109)1.95383022
72Acute necrotizing encephalopathy (HP:0006965)1.92637639
73Bronchitis (HP:0012387)1.92412627
74Cerebellar dysplasia (HP:0007033)1.92156048
75Male pseudohermaphroditism (HP:0000037)1.92120096
76Scotoma (HP:0000575)1.91391860
77Abnormal spermatogenesis (HP:0008669)1.91193882
78Reticulocytopenia (HP:0001896)1.90788931
79Oculomotor apraxia (HP:0000657)1.90750633
80Short tibia (HP:0005736)1.90267694
81Fibular aplasia (HP:0002990)1.87353344
82Abnormality of the nasal septum (HP:0000419)1.87269376
83Prominent nasal bridge (HP:0000426)1.86730387
84Absent frontal sinuses (HP:0002688)1.86671525
85Congenital stationary night blindness (HP:0007642)1.86451294
86Stage 5 chronic kidney disease (HP:0003774)1.85784097
87Atelectasis (HP:0100750)1.85474491
88Intellectual disability, moderate (HP:0002342)1.84550572
89Abnormality of cells of the erythroid lineage (HP:0012130)1.84385599
90Broad alveolar ridges (HP:0000187)1.82847212
91Hyperthyroidism (HP:0000836)1.81184522
92Aplasia/Hypoplasia of the tibia (HP:0005772)1.80548006
93Abnormality of molar (HP:0011077)1.79738564
94Abnormality of molar morphology (HP:0011070)1.79738564
95Abnormality of the dental root (HP:0006486)1.79023862
96Taurodontia (HP:0000679)1.79023862
97Abnormality of permanent molar morphology (HP:0011071)1.79023862
98Intestinal atresia (HP:0011100)1.77636590
99Multicystic kidney dysplasia (HP:0000003)1.77454698
100Highly arched eyebrow (HP:0002553)1.76351594
101Supernumerary spleens (HP:0009799)1.75903698
102Epileptic encephalopathy (HP:0200134)1.75596940
103Abnormality of the aortic arch (HP:0012303)1.75362213
104Drooling (HP:0002307)1.74689773
105Focal motor seizures (HP:0011153)1.73920960
106Double outlet right ventricle (HP:0001719)1.73649114
107Congenital malformation of the right heart (HP:0011723)1.73649114
108Severe visual impairment (HP:0001141)1.73467582
109Chorioretinal atrophy (HP:0000533)1.73185938
110Aplasia/Hypoplasia of the spleen (HP:0010451)1.72792623
111Cone-rod dystrophy (HP:0000548)1.71414590
112Abnormal mitochondria in muscle tissue (HP:0008316)1.70685888
113Nasal polyposis (HP:0100582)1.69885620
114Recurrent sinusitis (HP:0011108)1.67466434
115Sclerocornea (HP:0000647)1.66695379
116Acute encephalopathy (HP:0006846)1.65059371
117Renal dysplasia (HP:0000110)1.64995665
118* Short ribs (HP:0000773)1.64650880
119Cutaneous syndactyly (HP:0012725)1.64065243
120Keratoconus (HP:0000563)1.63935483
121Increased corneal curvature (HP:0100692)1.63935483
122Dandy-Walker malformation (HP:0001305)1.63268524
123Tubulointerstitial abnormality (HP:0001969)1.62697293
124Abnormal rod and cone electroretinograms (HP:0008323)1.62524729
125Epiphyseal dysplasia (HP:0002656)1.62509516
126Azoospermia (HP:0000027)1.61895755
127Attenuation of retinal blood vessels (HP:0007843)1.61813878
128Cutaneous finger syndactyly (HP:0010554)1.61330410
129Oligodactyly (HP:0012165)1.61249125
130Anencephaly (HP:0002323)1.61070765
131Metaphyseal dysplasia (HP:0100255)1.60466171
132Abnormality of the renal cortex (HP:0011035)1.60324405
133Holoprosencephaly (HP:0001360)1.60179004
134Retinitis pigmentosa (HP:0000510)1.60052849
135Neonatal short-limb short stature (HP:0008921)1.59436828
136Abnormality of the dental pulp (HP:0006479)1.59358261
137Abolished electroretinogram (ERG) (HP:0000550)1.59233706
138Male infertility (HP:0003251)1.58371438
139Genetic anticipation (HP:0003743)1.58294805
140Asplenia (HP:0001746)1.57412315
141Specific learning disability (HP:0001328)1.57101739
142Abnormality of abdominal situs (HP:0011620)1.56370475
143Abdominal situs inversus (HP:0003363)1.56370475
144Progressive macrocephaly (HP:0004481)1.55985460
145Broad-based gait (HP:0002136)1.55817838
146Hypoplastic ischia (HP:0003175)1.55704696
147Neoplasm of the oral cavity (HP:0100649)1.52109172
148Short foot (HP:0001773)1.51785929

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK3.42792840
2MAP2K73.38194960
3TNIK3.00528950
4SRPK12.79696275
5CASK2.77446024
6CDK192.58961875
7EPHA42.36400518
8MAPK132.32874755
9MAPK152.02930327
10PRKD31.99622790
11MAP4K21.94154690
12STK391.93633929
13PDK41.91633547
14PDK31.91633547
15FRK1.89994448
16MAP3K41.86774619
17PLK21.86687342
18NUAK11.85908070
19MAPKAPK51.84933066
20MKNK21.80281922
21PTK2B1.72353540
22ERBB31.65509342
23WNK31.64643188
24BMPR1B1.61447888
25TNK21.54038406
26NEK61.53301025
27NTRK31.52021971
28MKNK11.50277550
29EPHB21.43875310
30PDK21.35720950
31GRK11.31169950
32CDK31.30326380
33EEF2K1.30004722
34INSRR1.29752186
35DYRK21.26521277
36NME11.25458624
37BCR1.23395233
38SGK21.22784048
39PRKCG1.20804270
40CDC71.18786136
41SGK2231.18747729
42SGK4941.18747729
43PLK41.18473743
44PIK3CA1.17769849
45WNK41.08190707
46BRAF1.01641355
47DDR21.01195334
48TRPM71.00909466
49DYRK1A1.00822669
50CAMK11.00119553
51GRK70.99259726
52NEK20.97527287
53PINK10.96768346
54DMPK0.95076529
55BCKDK0.94840772
56TYRO30.93627946
57LRRK20.87336710
58AKT30.87160934
59SIK20.85394635
60OXSR10.82039934
61SIK30.80645462
62TRIM280.80426169
63PKN10.79159557
64MARK10.78509566
65RIPK10.78424154
66CSNK1E0.77625852
67MARK20.77379961
68ROCK20.76220611
69PRKG10.75822227
70RPS6KB10.74310974
71ERBB20.73157952
72BMPR20.72304070
73TAOK30.71426963
74MINK10.70994286
75CAMK1D0.70548355
76WNK10.69107613
77PRPF4B0.68625595
78CDK50.68538827
79STK160.68316975
80CDK80.65896087
81STK30.65841944
82NTRK20.65299047
83IKBKE0.64243049
84CAMK2D0.63959902
85CAMK2A0.63713797
86CAMK1G0.63084480
87CSNK1A1L0.62347969
88STK38L0.60643468
89PAK60.60023175
90PRKACA0.58523101
91DAPK20.58189993
92PRKD20.57958035
93MAP3K70.57514606
94SGK10.57509562
95PRKCE0.55276571
96CAMK2B0.53863472
97SGK30.53004278
98YES10.52612976
99ROCK10.52589424
100PRKAA10.51798714
101LATS10.51505536
102FGFR20.51274620
103MAP3K60.50196591
104FER0.49920019
105DYRK30.47924649
106NTRK10.46726313
107PLK10.46348146
108IRAK10.45997315
109ACVR1B0.45457031
110PRKCZ0.45179825
111CAMK40.44532326
112OBSCN0.44431514
113MELK0.44394694
114UHMK10.43788912
115PRKACB0.42884775
116PTK20.42799628
117CSNK1G20.42621545
118LATS20.42551017
119TIE10.42440184
120PHKG20.42421895
121PHKG10.42421895
122RPS6KA30.42257876
123PRKAA20.42236752
124GSK3B0.41392650
125AURKA0.40657875
126CDK20.40519871
127ADRBK20.40375117
128MAP2K40.39502327
129MAPK140.39463797
130CSNK1A10.39217501
131CDK10.38425824
132MAPKAPK20.38363690
133STK110.38058399
134CHEK20.37863679
135MAPK80.37804640
136PRKDC0.37346100
137CDC42BPA0.35390094
138RPS6KA20.34931908
139CSNK1G30.34751927
140ADRBK10.34642983
141CDK11A0.34555121
142PLK30.34491856
143MAPK120.34129255
144ATM0.33990487
145PAK30.33813489

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.74588443
2Nicotine addiction_Homo sapiens_hsa050333.36646706
3Olfactory transduction_Homo sapiens_hsa047402.88203145
4Circadian entrainment_Homo sapiens_hsa047132.43147194
5Amphetamine addiction_Homo sapiens_hsa050312.33912780
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.28386406
7Glutamatergic synapse_Homo sapiens_hsa047242.27391078
8Ribosome_Homo sapiens_hsa030102.18043011
9Parkinsons disease_Homo sapiens_hsa050122.09600568
10GABAergic synapse_Homo sapiens_hsa047272.04531083
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.01949603
12Morphine addiction_Homo sapiens_hsa050321.90838896
13Sphingolipid metabolism_Homo sapiens_hsa006001.82707216
14Renin secretion_Homo sapiens_hsa049241.76905350
15Taste transduction_Homo sapiens_hsa047421.74562728
16Long-term potentiation_Homo sapiens_hsa047201.74389746
17Synaptic vesicle cycle_Homo sapiens_hsa047211.71562059
18Serotonergic synapse_Homo sapiens_hsa047261.70702535
19Calcium signaling pathway_Homo sapiens_hsa040201.67818874
20Dopaminergic synapse_Homo sapiens_hsa047281.57802769
21Salivary secretion_Homo sapiens_hsa049701.56663131
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56053063
23Basal transcription factors_Homo sapiens_hsa030221.55760056
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49529205
25Insulin secretion_Homo sapiens_hsa049111.48104109
26Gastric acid secretion_Homo sapiens_hsa049711.46153058
27Huntingtons disease_Homo sapiens_hsa050161.45494335
28Fatty acid biosynthesis_Homo sapiens_hsa000611.41480514
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40020656
30Butanoate metabolism_Homo sapiens_hsa006501.39868994
31Cholinergic synapse_Homo sapiens_hsa047251.39732525
32Circadian rhythm_Homo sapiens_hsa047101.37663971
33Steroid biosynthesis_Homo sapiens_hsa001001.36090273
34Sulfur relay system_Homo sapiens_hsa041221.34705320
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34606232
36Ether lipid metabolism_Homo sapiens_hsa005651.34442242
37Axon guidance_Homo sapiens_hsa043601.34185848
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33390647
39Cocaine addiction_Homo sapiens_hsa050301.29961399
40ECM-receptor interaction_Homo sapiens_hsa045121.27833711
41Oxytocin signaling pathway_Homo sapiens_hsa049211.25275858
42Long-term depression_Homo sapiens_hsa047301.20496546
43Chemical carcinogenesis_Homo sapiens_hsa052041.17814736
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.12476875
45cAMP signaling pathway_Homo sapiens_hsa040241.12441464
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10027905
47Glucagon signaling pathway_Homo sapiens_hsa049221.06039980
48Propanoate metabolism_Homo sapiens_hsa006401.05396430
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05059306
50Peroxisome_Homo sapiens_hsa041461.01085367
51Vitamin B6 metabolism_Homo sapiens_hsa007500.99258885
52Nitrogen metabolism_Homo sapiens_hsa009100.98313108
53Melanogenesis_Homo sapiens_hsa049160.97560802
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97262399
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97113862
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96104020
57Retinol metabolism_Homo sapiens_hsa008300.95162736
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.92905866
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.92777358
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.91621586
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.91153426
62Fanconi anemia pathway_Homo sapiens_hsa034600.90962296
63Hedgehog signaling pathway_Homo sapiens_hsa043400.90847289
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89365830
65Wnt signaling pathway_Homo sapiens_hsa043100.88041477
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87682927
67Linoleic acid metabolism_Homo sapiens_hsa005910.86093322
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85695422
69Cardiac muscle contraction_Homo sapiens_hsa042600.84499204
70Oocyte meiosis_Homo sapiens_hsa041140.83184061
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82707108
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82210004
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81303760
74beta-Alanine metabolism_Homo sapiens_hsa004100.80972648
75Ovarian steroidogenesis_Homo sapiens_hsa049130.80771619
76Tyrosine metabolism_Homo sapiens_hsa003500.79945872
77GnRH signaling pathway_Homo sapiens_hsa049120.79633283
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79559316
79Pyruvate metabolism_Homo sapiens_hsa006200.77388544
80Basal cell carcinoma_Homo sapiens_hsa052170.75652214
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74921975
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74802499
83Lysine degradation_Homo sapiens_hsa003100.73872527
84Gap junction_Homo sapiens_hsa045400.73322368
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72857675
86Protein export_Homo sapiens_hsa030600.72247373
87RNA degradation_Homo sapiens_hsa030180.72181447
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72120014
89Phenylalanine metabolism_Homo sapiens_hsa003600.71995226
90Alzheimers disease_Homo sapiens_hsa050100.71655133
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70981660
92Thyroid hormone synthesis_Homo sapiens_hsa049180.69280833
93Fatty acid degradation_Homo sapiens_hsa000710.69233866
94Arachidonic acid metabolism_Homo sapiens_hsa005900.68351364
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67785696
96Caffeine metabolism_Homo sapiens_hsa002320.66542373
97Tight junction_Homo sapiens_hsa045300.66390113
98Mineral absorption_Homo sapiens_hsa049780.65674208
99Dilated cardiomyopathy_Homo sapiens_hsa054140.65554264
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65515679
101ABC transporters_Homo sapiens_hsa020100.65319097
102Purine metabolism_Homo sapiens_hsa002300.64354537
103Estrogen signaling pathway_Homo sapiens_hsa049150.64048518
104Protein digestion and absorption_Homo sapiens_hsa049740.62398022
105Collecting duct acid secretion_Homo sapiens_hsa049660.62359489
106Dorso-ventral axis formation_Homo sapiens_hsa043200.61574620
107TGF-beta signaling pathway_Homo sapiens_hsa043500.61246395
108RNA polymerase_Homo sapiens_hsa030200.60894364
109Arginine and proline metabolism_Homo sapiens_hsa003300.60538127
110Mismatch repair_Homo sapiens_hsa034300.59408918
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58964037
112MAPK signaling pathway_Homo sapiens_hsa040100.58246292
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57991530
114Metabolic pathways_Homo sapiens_hsa011000.55483062
115Bile secretion_Homo sapiens_hsa049760.53811705
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53687153
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53476370
118Oxidative phosphorylation_Homo sapiens_hsa001900.53350766
119Notch signaling pathway_Homo sapiens_hsa043300.53029526
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51437286
121Ras signaling pathway_Homo sapiens_hsa040140.51008168
122ErbB signaling pathway_Homo sapiens_hsa040120.50875171
123Pancreatic secretion_Homo sapiens_hsa049720.50619986
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50369929
125Tryptophan metabolism_Homo sapiens_hsa003800.49199483
126Vibrio cholerae infection_Homo sapiens_hsa051100.47668605
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47317720
128Hippo signaling pathway_Homo sapiens_hsa043900.45577443
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42286914
130mRNA surveillance pathway_Homo sapiens_hsa030150.41343861
131Homologous recombination_Homo sapiens_hsa034400.39682552
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38381750
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37296550
134Alcoholism_Homo sapiens_hsa050340.36945601
135Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32732797
136Rap1 signaling pathway_Homo sapiens_hsa040150.32487853
137Focal adhesion_Homo sapiens_hsa045100.30236984
138Nucleotide excision repair_Homo sapiens_hsa034200.28475080
139Glioma_Homo sapiens_hsa052140.27420746
140Prostate cancer_Homo sapiens_hsa052150.27140153

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