WDR62

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is proposed to play a role in cerebral cortical development. Mutations in this gene have been associated with microencephaly, cortical malformations, and mental retardation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.49169524
2cilium or flagellum-dependent cell motility (GO:0001539)8.94708391
3sperm motility (GO:0030317)8.33348492
4sperm-egg recognition (GO:0035036)7.77781030
5piRNA metabolic process (GO:0034587)7.44352659
6multicellular organism reproduction (GO:0032504)7.39712769
7axonemal dynein complex assembly (GO:0070286)7.23506781
8binding of sperm to zona pellucida (GO:0007339)7.17706792
9acrosome assembly (GO:0001675)7.14054527
10regulation of cilium movement (GO:0003352)7.08771574
11acrosome reaction (GO:0007340)7.02200447
12plasma membrane fusion (GO:0045026)6.98706281
13cell-cell recognition (GO:0009988)6.95769742
14cell wall macromolecule metabolic process (GO:0044036)6.90714429
15cell wall macromolecule catabolic process (GO:0016998)6.90714429
16motile cilium assembly (GO:0044458)6.90382354
17spermatid development (GO:0007286)6.68770485
18epithelial cilium movement (GO:0003351)6.56443661
19male meiosis (GO:0007140)6.20312773
20synaptonemal complex organization (GO:0070193)6.06497000
21reproduction (GO:0000003)6.02445688
22synaptonemal complex assembly (GO:0007130)5.97448407
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.58144844
24cilium movement (GO:0003341)5.50060454
25microtubule depolymerization (GO:0007019)5.26519394
26single fertilization (GO:0007338)5.07366829
27nuclear pore complex assembly (GO:0051292)5.03360068
28DNA unwinding involved in DNA replication (GO:0006268)4.98206247
29DNA strand elongation involved in DNA replication (GO:0006271)4.72151213
30male meiosis I (GO:0007141)4.58286156
31DNA methylation involved in gamete generation (GO:0043046)4.57526586
32DNA strand elongation (GO:0022616)4.57462077
33fertilization (GO:0009566)4.55256391
34nuclear pore organization (GO:0006999)4.51884723
35protein localization to chromosome, centromeric region (GO:0071459)4.50794888
36meiotic nuclear division (GO:0007126)4.47402680
37chromosome organization involved in meiosis (GO:0070192)4.45081528
38spermatogenesis (GO:0007283)4.43430537
39male gamete generation (GO:0048232)4.42435334
40sperm capacitation (GO:0048240)4.32041038
41DNA replication-dependent nucleosome organization (GO:0034723)4.27621176
42DNA replication-dependent nucleosome assembly (GO:0006335)4.27621176
43chromosome condensation (GO:0030261)4.26246600
44telomere maintenance via semi-conservative replication (GO:0032201)4.19853515
45ventricular system development (GO:0021591)4.17055512
46mitotic sister chromatid segregation (GO:0000070)4.16906730
47regulation of microtubule-based movement (GO:0060632)4.15128065
48germ cell development (GO:0007281)4.11244117
49heterochromatin organization (GO:0070828)4.09871405
50gamete generation (GO:0007276)4.07868837
51DNA packaging (GO:0006323)4.04382095
52meiotic cell cycle (GO:0051321)4.02137227
53pore complex assembly (GO:0046931)3.96332677
54meiosis I (GO:0007127)3.96028708
55cellular process involved in reproduction in multicellular organism (GO:0022412)3.94738410
56gene silencing by RNA (GO:0031047)3.92007274
57negative regulation of inclusion body assembly (GO:0090084)3.82742646
58organic cation transport (GO:0015695)3.74392323
59regulation of nuclear cell cycle DNA replication (GO:0033262)3.72991482
60protein localization to kinetochore (GO:0034501)3.72587098
61positive regulation of chromosome segregation (GO:0051984)3.68889629
62sister chromatid segregation (GO:0000819)3.66977793
63seminiferous tubule development (GO:0072520)3.63726822
64mitotic sister chromatid cohesion (GO:0007064)3.61718520
65microtubule severing (GO:0051013)3.59129806
66regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.58926126
67regulation of histone H3-K9 methylation (GO:0051570)3.58385980
68telomere maintenance via recombination (GO:0000722)3.55621294
69regulation of translational fidelity (GO:0006450)3.44053175
70DNA strand renaturation (GO:0000733)3.43126186
71DNA duplex unwinding (GO:0032508)3.42577803
72mitotic recombination (GO:0006312)3.40948873
73regulation of spindle checkpoint (GO:0090231)3.40319997
74meiotic cell cycle process (GO:1903046)3.39482323
75DNA geometric change (GO:0032392)3.36040782
76regulation of centriole replication (GO:0046599)3.35626796
77DNA synthesis involved in DNA repair (GO:0000731)3.33793325
78replication fork processing (GO:0031297)3.33641853
79nucleotide-excision repair, DNA gap filling (GO:0006297)3.32377491
80mitotic nuclear envelope disassembly (GO:0007077)3.31058264
81regulation of inclusion body assembly (GO:0090083)3.30092289
82protein polyglutamylation (GO:0018095)3.28832690
83regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.28408494
84monoubiquitinated protein deubiquitination (GO:0035520)3.27629476
85chaperone-mediated protein complex assembly (GO:0051131)3.23365761
86kinetochore organization (GO:0051383)3.21880502
87multicellular organismal reproductive process (GO:0048609)3.20454549
88maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.18818249
89gene silencing (GO:0016458)3.18455882
90negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.17130977
91nucleus organization (GO:0006997)3.13045479
92negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.12010300
93chromatin assembly (GO:0031497)3.11579498
94regulation of response to osmotic stress (GO:0047484)3.10484886
95nuclear envelope disassembly (GO:0051081)3.08421634
96membrane disassembly (GO:0030397)3.08421634
97chromosome segregation (GO:0007059)3.07437174
98somatic hypermutation of immunoglobulin genes (GO:0016446)3.05182144
99somatic diversification of immune receptors via somatic mutation (GO:0002566)3.05182144
100mitotic metaphase plate congression (GO:0007080)3.03571621
101regulation of centrosome duplication (GO:0010824)3.03318039
102left/right pattern formation (GO:0060972)3.01189669
103DNA conformation change (GO:0071103)3.00690621
104translesion synthesis (GO:0019985)2.99979554
105genitalia morphogenesis (GO:0035112)2.96719388
106histone exchange (GO:0043486)2.96633142
107pseudouridine synthesis (GO:0001522)2.96234975
108regulation of DNA endoreduplication (GO:0032875)2.95627729
109regulation of posttranscriptional gene silencing (GO:0060147)2.95408469
110regulation of gene silencing by miRNA (GO:0060964)2.95408469
111regulation of gene silencing by RNA (GO:0060966)2.95408469
112protein K6-linked ubiquitination (GO:0085020)2.94939366
113viral mRNA export from host cell nucleus (GO:0046784)2.93444558
114regulation of DNA-dependent DNA replication (GO:0090329)2.92427449
115mitotic chromosome condensation (GO:0007076)2.92400051
116regulation of meiosis I (GO:0060631)2.92132268
117meiotic chromosome segregation (GO:0045132)2.90093440
118DNA replication (GO:0006260)2.88332495
119negative regulation of cell cycle G2/M phase transition (GO:1902750)2.88245845
120spliceosomal tri-snRNP complex assembly (GO:0000244)2.87846121
121cell recognition (GO:0008037)2.87335487
122regulation of sister chromatid cohesion (GO:0007063)2.86984075
123chromatin assembly or disassembly (GO:0006333)2.86510231
124negative regulation of mRNA processing (GO:0050686)2.85741334
125sister chromatid cohesion (GO:0007062)2.84053180
126chromatin remodeling at centromere (GO:0031055)2.83885852
127spindle assembly (GO:0051225)2.83602996
128telomere maintenance via telomere lengthening (GO:0010833)2.83357352
129histone-serine phosphorylation (GO:0035404)2.82675196
130mRNA stabilization (GO:0048255)2.79967698
131RNA stabilization (GO:0043489)2.79967698
132tRNA methylation (GO:0030488)2.79379869
133interferon-gamma secretion (GO:0072643)2.77742206
134regulation of chromosome segregation (GO:0051983)2.77350955
135chromosome organization (GO:0051276)2.75715542
136inner cell mass cell proliferation (GO:0001833)2.74931664
137regulation of centrosome cycle (GO:0046605)2.74474648
138ribosome biogenesis (GO:0042254)2.73670347
139DNA replication initiation (GO:0006270)2.73508884
140DNA topological change (GO:0006265)2.73301019
141single strand break repair (GO:0000012)2.73173868
142folic acid-containing compound biosynthetic process (GO:0009396)2.72901010
143protein localization to chromosome (GO:0034502)2.72858989
144positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.72323180
145positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.72323180
146positive regulation of mitotic sister chromatid separation (GO:1901970)2.72323180
147DNA replication checkpoint (GO:0000076)2.71989791
148synapsis (GO:0007129)2.71944316
149spindle organization (GO:0007051)2.71096294
150mitochondrial RNA metabolic process (GO:0000959)2.70777480
151kinetochore assembly (GO:0051382)2.69628953
152IMP biosynthetic process (GO:0006188)2.69004818
153nucleosome disassembly (GO:0006337)2.68950550
154protein-DNA complex disassembly (GO:0032986)2.68950550
155CENP-A containing nucleosome assembly (GO:0034080)2.68783259
156tRNA modification (GO:0006400)2.67963058
157nuclear envelope organization (GO:0006998)2.66862199
158recombinational repair (GO:0000725)2.66496711
159double-strand break repair via homologous recombination (GO:0000724)2.66419165
160nucleobase biosynthetic process (GO:0046112)2.65905058
161DNA biosynthetic process (GO:0071897)2.65322024
162IMP metabolic process (GO:0046040)2.63371846
163metaphase plate congression (GO:0051310)2.62103735
164mitotic cell cycle (GO:0000278)2.61940218
165positive regulation of DNA-dependent DNA replication (GO:2000105)2.60806503

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.16881489
2E2F7_22180533_ChIP-Seq_HELA_Human6.79357388
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.65397982
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.05512314
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.85077399
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79539423
7THAP11_20581084_ChIP-Seq_MESCs_Mouse2.45147212
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.39413471
9CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.23963286
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.20002952
11TTF2_22483619_ChIP-Seq_HELA_Human1.96553020
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.86754328
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.86754328
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.86754328
15MYC_18555785_ChIP-Seq_MESCs_Mouse1.86722233
16* DCP1A_22483619_ChIP-Seq_HELA_Human1.83694626
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76542118
18NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.74349465
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73253096
20MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67953663
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65963899
22YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65445622
23CIITA_25753668_ChIP-Seq_RAJI_Human1.63027718
24STAT3_1855785_ChIP-Seq_MESCs_Mouse1.59543904
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58858108
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.56165727
27GATA1_26923725_Chip-Seq_HPCs_Mouse1.54943877
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54209244
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51113424
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.50906921
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50484134
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.46862047
33AR_21909140_ChIP-Seq_LNCAP_Human1.43199480
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42388536
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41621863
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40213930
37KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37399946
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36930561
39MYC_18940864_ChIP-ChIP_HL60_Human1.34693581
40FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33300343
41BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33077875
42PKCTHETA_26484144_Chip-Seq_BREAST_Human1.32654930
43* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29990581
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29870925
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28339242
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28222611
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.27939791
48DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27661066
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27239583
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.26219360
51P68_20966046_ChIP-Seq_HELA_Human1.24655384
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23791637
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23562524
54MYC_22102868_ChIP-Seq_BL_Human1.23227065
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.21521146
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21418965
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19678869
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.17484286
59FOXP1_21924763_ChIP-Seq_HESCs_Human1.17185032
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.17017130
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16526209
62CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15977722
63YY1_22570637_ChIP-Seq_MALME-3M_Human1.14918232
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14145989
65* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13447962
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13095896
67ELK4_26923725_Chip-Seq_MESODERM_Mouse1.11945592
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11798908
69* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11221939
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11198192
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10567917
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09539837
73XRN2_22483619_ChIP-Seq_HELA_Human1.07974155
74PHF8_20622854_ChIP-Seq_HELA_Human1.07564056
75SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06604534
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06037861
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.03845921
78TCF7_22412390_ChIP-Seq_EML_Mouse1.03688967
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01695149
80FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01240346
81* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00671914
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98946489
83KDM5A_27292631_Chip-Seq_BREAST_Human0.98372464
84RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98344669
85SPI1_26923725_Chip-Seq_HPCs_Mouse0.96567689
86NANOG_21062744_ChIP-ChIP_HESCs_Human0.96403696
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94702083
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93843607
89RARA_24833708_ChIP-Seq_LIVER_Mouse0.93737121
90TP53_22127205_ChIP-Seq_IMR90_Human0.93583751
91BCOR_27268052_Chip-Seq_Bcells_Human0.93471487
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92360711
93GABP_19822575_ChIP-Seq_HepG2_Human0.92243219
94JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.92034864
95PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91959923
96CREB1_15753290_ChIP-ChIP_HEK293T_Human0.91593712
97CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91227715
98POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.91008502
99TET1_21451524_ChIP-Seq_MESCs_Mouse0.90580058
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89900104
101ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89794710
102MYB_26560356_Chip-Seq_TH1_Human0.89132916
103NELFA_20434984_ChIP-Seq_ESCs_Mouse0.88038183
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87665165
105TBX5_21415370_ChIP-Seq_HL-1_Mouse0.87518297
106SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86737693
107PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86641049
108POU5F1_16518401_ChIP-PET_MESCs_Mouse0.86135114
109FOXP3_21729870_ChIP-Seq_TREG_Human0.85143819
110E2F1_20622854_ChIP-Seq_HELA_Human0.83674974
111ZNF274_21170338_ChIP-Seq_K562_Hela0.83279140
112EST1_17652178_ChIP-ChIP_JURKAT_Human0.82841166
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82567199
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82473905
115SOX2_18692474_ChIP-Seq_MESCs_Mouse0.82135983
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81620723
117VDR_21846776_ChIP-Seq_THP-1_Human0.81255598
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80928096
119PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80851907
120NCOR1_26117541_ChIP-Seq_K562_Human0.80617630
121GATA3_21867929_ChIP-Seq_CD8_Mouse0.80332226
122RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.80228572
123TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.80032536
124E2F1_17053090_ChIP-ChIP_MCF-7_Human0.79800609
125STAT1_20625510_ChIP-Seq_HELA_Human0.79444972
126VDR_23849224_ChIP-Seq_CD4+_Human0.79403220
127EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.78823504
128CTCF_26484167_Chip-Seq_Bcells_Mouse0.78805111
129PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78759545
130SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.78692863
131ELK1_19687146_ChIP-ChIP_HELA_Human0.78668390
132SALL1_21062744_ChIP-ChIP_HESCs_Human0.78478647
133POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.78341419
134TCF3_18692474_ChIP-Seq_MESCs_Mouse0.78149197
135ETS1_20019798_ChIP-Seq_JURKAT_Human0.77371935
136WDR5_24793694_ChIP-Seq_LNCAP_Human0.77342673
137EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.75131390
138MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.74332020
139SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73745602
140SOX2_16153702_ChIP-ChIP_HESCs_Human0.73323285
141ZNF263_19887448_ChIP-Seq_K562_Human0.73192237
142RARB_24833708_ChIP-Seq_LIVER_Mouse0.72869070
143HOXB4_20404135_ChIP-ChIP_EML_Mouse0.71259575
144RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.71223245
145* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.70909251

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.15105320
2MP0001929_abnormal_gametogenesis4.08498092
3MP0008877_abnormal_DNA_methylation4.04719821
4MP0008057_abnormal_DNA_replication3.83353015
5MP0002653_abnormal_ependyma_morphology3.46430433
6MP0010094_abnormal_chromosome_stability3.31607348
7MP0003111_abnormal_nucleus_morphology3.06370964
8MP0002210_abnormal_sex_determination3.04634726
9MP0001145_abnormal_male_reproductive2.68398540
10MP0004957_abnormal_blastocyst_morpholog2.46089361
11MP0003077_abnormal_cell_cycle2.44468652
12MP0002161_abnormal_fertility/fecundity2.37536646
13MP0003693_abnormal_embryo_hatching2.32267794
14MP0008058_abnormal_DNA_repair2.27656410
15MP0000653_abnormal_sex_gland2.19353823
16MP0005410_abnormal_fertilization10.0367993
17MP0004145_abnormal_muscle_electrophysio1.90199659
18MP0001661_extended_life_span1.83143145
19MP0008007_abnormal_cellular_replicative1.79180497
20MP0005670_abnormal_white_adipose1.77058876
21MP0004185_abnormal_adipocyte_glucose1.71565852
22MP0010352_gastrointestinal_tract_polyps1.69369151
23MP0003718_maternal_effect1.65943559
24MP0001730_embryonic_growth_arrest1.64568669
25MP0003786_premature_aging1.62287313
26MP0000749_muscle_degeneration1.58842141
27MP0010307_abnormal_tumor_latency1.57805964
28MP0009278_abnormal_bone_marrow1.55061214
29MP0005380_embryogenesis_phenotype1.54633936
30MP0001672_abnormal_embryogenesis/_devel1.54633936
31MP0000350_abnormal_cell_proliferation1.51746855
32MP0003136_yellow_coat_color1.51610238
33MP0005623_abnormal_meninges_morphology1.47844504
34MP0004264_abnormal_extraembryonic_tissu1.46386957
35MP0005397_hematopoietic_system_phenotyp1.38833718
36MP0001545_abnormal_hematopoietic_system1.38833718
37MP0003984_embryonic_growth_retardation1.36167679
38MP0000751_myopathy1.35763385
39MP0003890_abnormal_embryonic-extraembry1.35546919
40MP0002160_abnormal_reproductive_system1.34167436
41MP0008932_abnormal_embryonic_tissue1.34091020
42MP0009697_abnormal_copulation1.33550797
43MP0002088_abnormal_embryonic_growth/wei1.32890997
44MP0003937_abnormal_limbs/digits/tail_de1.32071720
45MP0001293_anophthalmia1.28384133
46MP0001697_abnormal_embryo_size1.26515629
47MP0002084_abnormal_developmental_patter1.25950583
48MP0002163_abnormal_gland_morphology1.22335338
49MP0005076_abnormal_cell_differentiation1.19845175
50MP0002085_abnormal_embryonic_tissue1.19625363
51MP0002086_abnormal_extraembryonic_tissu1.18200226
52MP0000003_abnormal_adipose_tissue1.18170037
53MP0000747_muscle_weakness1.18079827
54MP0000313_abnormal_cell_death1.17935284
55MP0005451_abnormal_body_composition1.16579801
56MP0004197_abnormal_fetal_growth/weight/1.14969723
57MP0008995_early_reproductive_senescence1.14469390
58MP0003705_abnormal_hypodermis_morpholog1.13960290
59MP0001346_abnormal_lacrimal_gland1.12820038
60MP0002080_prenatal_lethality1.12413857
61MP0000759_abnormal_skeletal_muscle1.11605341
62MP0002938_white_spotting1.10751471
63MP0002106_abnormal_muscle_physiology1.08467774
64MP0002249_abnormal_larynx_morphology1.08345712
65MP0004808_abnormal_hematopoietic_stem1.05248735
66MP0002282_abnormal_trachea_morphology1.04513223
67MP0003950_abnormal_plasma_membrane1.00714655
68MP0005075_abnormal_melanosome_morpholog0.99201811
69MP0004233_abnormal_muscle_weight0.99154978
70MP0004087_abnormal_muscle_fiber0.97799735
71MP0000358_abnormal_cell_content/0.97107504
72MP0005171_absent_coat_pigmentation0.97105151
73MP0002396_abnormal_hematopoietic_system0.96627590
74MP0003011_delayed_dark_adaptation0.95299382
75MP0000569_abnormal_digit_pigmentation0.94742325
76MP0005083_abnormal_biliary_tract0.94118965
77MP0006036_abnormal_mitochondrial_physio0.92693483
78MP0002019_abnormal_tumor_incidence0.92532588
79MP0000733_abnormal_muscle_development0.92253378
80MP0005369_muscle_phenotype0.91757872
81MP0002697_abnormal_eye_size0.91566369
82MP0001849_ear_inflammation0.91462302
83MP0000750_abnormal_muscle_regeneration0.91135476
84MP0000490_abnormal_crypts_of0.90932608
85MP0000537_abnormal_urethra_morphology0.86231638
86MP0002092_abnormal_eye_morphology0.82347691
87MP0004147_increased_porphyrin_level0.79888383
88MP0000049_abnormal_middle_ear0.79162160
89MP0004130_abnormal_muscle_cell0.77572852
90MP0003943_abnormal_hepatobiliary_system0.77183172
91MP0000372_irregular_coat_pigmentation0.77025646
92MP0002111_abnormal_tail_morphology0.76923096
93MP0004036_abnormal_muscle_relaxation0.76540079
94MP0005389_reproductive_system_phenotype0.75740474
95MP0004133_heterotaxia0.75578504
96MP0001286_abnormal_eye_development0.74527740
97MP0002234_abnormal_pharynx_morphology0.73356345
98MP0003115_abnormal_respiratory_system0.73076393
99MP0001348_abnormal_lacrimal_gland0.72353709
100MP0005645_abnormal_hypothalamus_physiol0.70989670
101MP0003283_abnormal_digestive_organ0.70831374
102MP0005330_cardiomyopathy0.70347339
103MP0005647_abnormal_sex_gland0.69662633
104MP0003942_abnormal_urinary_system0.68452439
105MP0003315_abnormal_perineum_morphology0.68169468
106MP0003121_genomic_imprinting0.67747377
107MP0002114_abnormal_axial_skeleton0.67608535
108MP0002269_muscular_atrophy0.66275362
109MP0003755_abnormal_palate_morphology0.64218639
110MP0002405_respiratory_system_inflammati0.64170667
111MP0005377_hearing/vestibular/ear_phenot0.61994120
112MP0003878_abnormal_ear_physiology0.61994120
113MP0006292_abnormal_olfactory_placode0.61004289
114MP0000703_abnormal_thymus_morphology0.60955262
115MP0001119_abnormal_female_reproductive0.59229198
116MP0002970_abnormal_white_adipose0.59099677
117MP0003699_abnormal_female_reproductive0.58870771
118MP0009703_decreased_birth_body0.58715562
119MP0002398_abnormal_bone_marrow0.58416549
120MP0000689_abnormal_spleen_morphology0.58363040
121MP0009115_abnormal_fat_cell0.58305253
122MP0008770_decreased_survivor_rate0.56962179
123MP0005174_abnormal_tail_pigmentation0.56929797
124MP0005266_abnormal_metabolism0.56803567
125MP0003123_paternal_imprinting0.56584886
126MP0005384_cellular_phenotype0.56032162
127MP0003119_abnormal_digestive_system0.54649217
128MP0000432_abnormal_head_morphology0.54167773
129MP0006035_abnormal_mitochondrial_morpho0.53366396
130MP0002254_reproductive_system_inflammat0.53350324
131MP0002722_abnormal_immune_system0.52547020
132MP0005023_abnormal_wound_healing0.52364979
133MP0001915_intracranial_hemorrhage0.52179480
134MP0010030_abnormal_orbit_morphology0.52115253
135MP0002925_abnormal_cardiovascular_devel0.50350250
136MP0008961_abnormal_basal_metabolism0.50152509
137MP0003448_altered_tumor_morphology0.49279261
138MP0005391_vision/eye_phenotype0.47634960
139MP0005621_abnormal_cell_physiology0.47389384
140MP0003646_muscle_fatigue0.46419053
141MP0003566_abnormal_cell_adhesion0.45410286
142MP0009672_abnormal_birth_weight0.45355110
143MP0005257_abnormal_intraocular_pressure0.44716958
144MP0003861_abnormal_nervous_system0.43934212

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.65435433
2Absent/shortened dynein arms (HP:0200106)9.65435433
3Abnormal respiratory epithelium morphology (HP:0012253)6.88502164
4Abnormal respiratory motile cilium morphology (HP:0005938)6.88502164
5Abnormal respiratory motile cilium physiology (HP:0012261)6.80804435
6Nasal polyposis (HP:0100582)6.27044719
7Rhinitis (HP:0012384)6.00510224
8Chronic bronchitis (HP:0004469)5.49339532
9Infertility (HP:0000789)5.23255851
10Abnormal ciliary motility (HP:0012262)5.18719605
11Abnormality of the nasal mucosa (HP:0000433)5.10498145
12Birth length less than 3rd percentile (HP:0003561)4.31858719
13Bronchitis (HP:0012387)3.91907588
14Male infertility (HP:0003251)3.82728976
15Abnormality of the lower motor neuron (HP:0002366)3.75724267
16Bronchiectasis (HP:0002110)3.72570629
17Patellar aplasia (HP:0006443)3.40394848
18Nephronophthisis (HP:0000090)3.33068148
19Aplasia/Hypoplasia of the patella (HP:0006498)3.21567813
20Abnormal spermatogenesis (HP:0008669)3.13929764
21Duplicated collecting system (HP:0000081)3.02515158
22Progressive muscle weakness (HP:0003323)3.02014845
23Recurrent bronchitis (HP:0002837)2.86952959
24Abnormality of DNA repair (HP:0003254)2.82397234
25Recurrent otitis media (HP:0000403)2.80370259
26Breast hypoplasia (HP:0003187)2.78008885
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.77301017
28Muscle fiber inclusion bodies (HP:0100299)2.73244195
29Myopathic facies (HP:0002058)2.69969456
30Short thumb (HP:0009778)2.69047065
31Reticulocytopenia (HP:0001896)2.66876576
32Nemaline bodies (HP:0003798)2.64099733
33Ependymoma (HP:0002888)2.63490504
34Selective tooth agenesis (HP:0001592)2.61181399
35Gonadotropin excess (HP:0000837)2.60551948
36Cerebellar dysplasia (HP:0007033)2.60457513
37Abnormality of the renal collecting system (HP:0004742)2.59704209
38Amyotrophic lateral sclerosis (HP:0007354)2.59578690
39Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.56175647
40Chromsome breakage (HP:0040012)2.54717606
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.54634372
42Absent radius (HP:0003974)2.50855671
43Hypoplasia of the pons (HP:0012110)2.43773195
44Supernumerary spleens (HP:0009799)2.42212904
45Hypoplasia of the capital femoral epiphysis (HP:0003090)2.42137279
46Short humerus (HP:0005792)2.41007562
47Degeneration of anterior horn cells (HP:0002398)2.40139649
48Abnormality of the anterior horn cell (HP:0006802)2.40139649
49Recurrent sinusitis (HP:0011108)2.39053349
50Abnormality of the ileum (HP:0001549)2.37877567
51Meckel diverticulum (HP:0002245)2.37739392
52Nephroblastoma (Wilms tumor) (HP:0002667)2.36646860
53Abnormality of the renal medulla (HP:0100957)2.35317376
54Abnormal number of incisors (HP:0011064)2.34246036
55Type II lissencephaly (HP:0007260)2.33512138
56Aplasia/hypoplasia of the humerus (HP:0006507)2.33328381
57Absent forearm bone (HP:0003953)2.32649641
58Aplasia involving forearm bones (HP:0009822)2.32649641
59Abnormality of the pons (HP:0007361)2.29642276
60Abnormality of cochlea (HP:0000375)2.29466592
61Horseshoe kidney (HP:0000085)2.20390596
62Embryonal renal neoplasm (HP:0011794)2.16103995
63Abnormal number of erythroid precursors (HP:0012131)2.14977771
64Azoospermia (HP:0000027)2.14081591
65* Impulsivity (HP:0100710)2.13748334
66Testicular atrophy (HP:0000029)2.12676615
67Calcaneovalgus deformity (HP:0001848)2.09319384
68Optic nerve coloboma (HP:0000588)2.08462143
69Abnormality of chromosome stability (HP:0003220)2.07876614
70Ectopic kidney (HP:0000086)2.05160762
71Small intestinal stenosis (HP:0012848)2.04943533
72Duodenal stenosis (HP:0100867)2.04943533
73Upper motor neuron abnormality (HP:0002127)2.04890721
74Rib fusion (HP:0000902)2.04347283
75Molar tooth sign on MRI (HP:0002419)2.04171326
76Abnormality of midbrain morphology (HP:0002418)2.04171326
77Exercise-induced myalgia (HP:0003738)2.04156134
78Absent frontal sinuses (HP:0002688)2.04087544
79Poikiloderma (HP:0001029)2.03756015
80Abnormality of the preputium (HP:0100587)2.02779172
81Microvesicular hepatic steatosis (HP:0001414)2.00385877
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.4607152
83Tubular atrophy (HP:0000092)1.99249035
84Short ribs (HP:0000773)1.96021971
85Ureteral duplication (HP:0000073)1.95734563
86Tubulointerstitial nephritis (HP:0001970)1.94274273
87Tongue fasciculations (HP:0001308)1.94039902
88Facial cleft (HP:0002006)1.93378759
89Abnormality of the astrocytes (HP:0100707)1.93202290
90Astrocytoma (HP:0009592)1.93202290
91Aplasia/Hypoplasia of the sacrum (HP:0008517)1.93071912
92Septate vagina (HP:0001153)1.92471993
93Neoplasm of striated muscle (HP:0009728)1.91304427
94Homocystinuria (HP:0002156)1.88958225
95Abnormality of homocysteine metabolism (HP:0010919)1.88958225
96High anterior hairline (HP:0009890)1.88312552
97Duplication of thumb phalanx (HP:0009942)1.88254085
98Abnormality of cells of the erythroid lineage (HP:0012130)1.88193121
99* Sloping forehead (HP:0000340)1.86746194
100Abnormality of the calcaneus (HP:0008364)1.85830850
101Partial agenesis of the corpus callosum (HP:0001338)1.83740128
102Triphalangeal thumb (HP:0001199)1.82012666
103Retinal dysplasia (HP:0007973)1.81309257
104Pendular nystagmus (HP:0012043)1.80401145
105Abnormality of chromosome segregation (HP:0002916)1.80288679
106Morphological abnormality of the inner ear (HP:0011390)1.80200257
107Cafe-au-lait spot (HP:0000957)1.79509353
108Bilateral microphthalmos (HP:0007633)1.79319756
109Medulloblastoma (HP:0002885)1.79311340
110Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.79277160
111Postaxial foot polydactyly (HP:0001830)1.78978157
112Abnormality of the carotid arteries (HP:0005344)1.78894288
113Deformed tarsal bones (HP:0008119)1.77764906
114Muscle fibrillation (HP:0010546)1.77514964
115Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.75538197
116Absent epiphyses (HP:0010577)1.75538197
117Volvulus (HP:0002580)1.75068961
118Myelodysplasia (HP:0002863)1.74892080
119Hyperacusis (HP:0010780)1.73587775
120Hand muscle atrophy (HP:0009130)1.73459974
121Abnormality of abdominal situs (HP:0011620)1.72743180
122Abdominal situs inversus (HP:0003363)1.72743180
123Atresia of the external auditory canal (HP:0000413)1.72681113
124High pitched voice (HP:0001620)1.69661027
125Absent thumb (HP:0009777)1.69580162
126Atrophy/Degeneration involving motor neurons (HP:0007373)1.69517237
12711 pairs of ribs (HP:0000878)1.68780253
128Ulnar bowing (HP:0003031)1.68672418
129Exercise-induced muscle cramps (HP:0003710)1.67233773
130Impaired proprioception (HP:0010831)1.66101327
131Muscle hypertrophy of the lower extremities (HP:0008968)1.63027086
132Proximal placement of thumb (HP:0009623)1.62945850
133Missing ribs (HP:0000921)1.62789209
134Rhabdomyosarcoma (HP:0002859)1.62451815
135Hypopigmentation of the fundus (HP:0007894)1.61207440
136Severe muscular hypotonia (HP:0006829)1.60544533
137Urethral obstruction (HP:0000796)1.59969752
138Microretrognathia (HP:0000308)1.59794269
139Bile duct proliferation (HP:0001408)1.59467777
140Abnormal biliary tract physiology (HP:0012439)1.59467777
141Obsessive-compulsive behavior (HP:0000722)1.58155485
142Prominent nose (HP:0000448)1.56891592
143Rectal fistula (HP:0100590)1.56611940
144Rectovaginal fistula (HP:0000143)1.56611940
145Spinal muscular atrophy (HP:0007269)1.56447988
146Abnormality of the duodenum (HP:0002246)1.56436237
147Sclerocornea (HP:0000647)1.55260217
148Abnormal lung lobation (HP:0002101)1.54979257
149Increased nuchal translucency (HP:0010880)1.54615946
150Deformed sella turcica (HP:0002681)1.53183738
151Intestinal fistula (HP:0100819)1.52474806
152Dysmetric saccades (HP:0000641)1.52348235
153Clubbing of toes (HP:0100760)1.52003512
154Large for gestational age (HP:0001520)1.51954125
155Broad distal phalanx of finger (HP:0009836)1.51933110
156Arteriovenous malformation (HP:0100026)1.51273145
157Neoplasm of the oral cavity (HP:0100649)1.50863365
158Abnormality of reticulocytes (HP:0004312)1.49806772
159Preaxial hand polydactyly (HP:0001177)1.49583675
160Facial hemangioma (HP:0000329)1.49531024
161Slender long bone (HP:0003100)1.49233261
162Glioma (HP:0009733)1.46696451
163Squamous cell carcinoma (HP:0002860)1.46411719
164Oculomotor apraxia (HP:0000657)1.46276846
165Congenital hepatic fibrosis (HP:0002612)1.45711599
166Bone marrow hypocellularity (HP:0005528)1.42382197
167Personality changes (HP:0000751)1.42308333
168Hypochromic microcytic anemia (HP:0004840)1.42212135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.89617335
2PDK45.89617335
3TESK14.40274820
4CDK124.27001630
5ICK4.26649025
6PRKD33.77661107
7PDK23.70046949
8NEK23.23192734
9ZAK2.94093377
10CDC72.68098422
11SMG12.35222786
12TTK2.22213823
13WEE12.10218370
14VRK21.98028745
15TTN1.92180131
16TAF11.83891269
17CDK81.80033159
18OBSCN1.68810589
19PHKG21.66205755
20PHKG11.66205755
21PNCK1.64669327
22BUB11.60932953
23NME11.57879174
24IRAK31.56132221
25CHEK21.54675671
26TYRO31.53891911
27CAMK1D1.50329385
28MAP3K101.49848132
29EEF2K1.44094145
30STK101.41071885
31PLK11.39092956
32CDK71.38699176
33DYRK1B1.33194247
34ATR1.27645102
35DYRK31.27116193
36PTK2B1.27059603
37CHEK11.21694062
38MKNK21.21510789
39MAPK111.19806301
40PASK1.17461885
41STK31.15281928
42STK381.12852332
43TESK21.12454669
44TSSK61.08581128
45GRK61.08251902
46ERN11.08006689
47BMPR1B1.07819943
48VRK11.06851185
49FRK1.03765969
50CSF1R1.01360715
51CDK40.99819816
52MTOR0.97072238
53PAK40.94667936
54MST1R0.92587892
55PBK0.92441910
56PLK40.89570589
57WNK10.88850977
58SIK20.87457769
59ATM0.86181727
60BRAF0.82351567
61MKNK10.82115162
62BRSK20.78628201
63WNK40.76832045
64AURKB0.76582989
65CCNB10.76428161
66MATK0.71891301
67SIK10.68953706
68MUSK0.66921430
69CDK60.66880315
70CDK90.66720349
71PAK10.66420996
72INSRR0.65977320
73GRK50.65809930
74PRKCI0.65400616
75NME20.65039262
76PIM10.64878876
77CDK20.64574622
78NEK10.62965708
79RPS6KA50.62499892
80AURKA0.61928931
81MELK0.61745645
82MAPK150.57436438
83MAP3K90.54209965
84RPS6KB20.53855827
85STK40.53664948
86MAP2K20.52482603
87BRD40.52476180
88EIF2AK10.49515582
89BRSK10.49162137
90MET0.48085799
91MAP3K80.47110200
92EPHA20.47090958
93TLK10.46427679
94PDK10.45776817
95TRIB30.44868359
96MAP4K10.44854123
97STK390.44026951
98CDK10.44008275
99PAK20.43791537
100CAMK1G0.43765179
101PKN20.41918264
102MAPKAPK50.40360741
103MAPKAPK30.40089760
104CAMK40.39643847
105CSK0.39378558
106TGFBR20.38199285
107KDR0.37058256
108MAP3K70.35716911
109AKT10.35073913
110RPS6KA60.34159080
111CSNK1E0.33811580
112SRPK10.33038051
113BMX0.31593950
114MAPK70.30441503
115CSNK1A1L0.29349805
116YES10.28623191
117PRKAA10.27935970
118GRK10.27906595
119ACVR1B0.27693246
120CSNK2A10.27507212
121RPS6KA40.27212277
122MARK20.26760978
123EIF2AK20.26283221
124NUAK10.26018057
125ILK0.24952326
126CSNK1G30.24777617
127MAPK10.23524911
128CSNK2A20.23104354
129GSK3B0.22075347
130STK38L0.21678415
131MAPK140.20585130
132ADRBK20.19887599
133CSNK1D0.19635248
134MAP2K60.19445618
135CLK10.18075019
136MARK30.18073987
137AKT20.18048797
138SCYL20.17719276
139RPS6KA10.17525356
140AKT30.17126725
141PRKDC0.16708415
142ALK0.16620738
143ZAP700.13591748
144DDR20.13175295
145RIPK10.12718223
146EGFR0.12696546
147MAP3K60.12562697
148PLK30.12549822

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.91084975
2Vitamin B6 metabolism_Homo sapiens_hsa007503.57814044
3Fanconi anemia pathway_Homo sapiens_hsa034603.27071959
4Mismatch repair_Homo sapiens_hsa034303.20054660
5RNA transport_Homo sapiens_hsa030133.14442949
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.90114808
7Base excision repair_Homo sapiens_hsa034102.68505934
8Homologous recombination_Homo sapiens_hsa034402.61036173
9mRNA surveillance pathway_Homo sapiens_hsa030152.48401930
10Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.45817631
11Basal transcription factors_Homo sapiens_hsa030222.40455191
12Cell cycle_Homo sapiens_hsa041102.39162605
13Fatty acid biosynthesis_Homo sapiens_hsa000612.28439550
14Spliceosome_Homo sapiens_hsa030402.14343643
15Fructose and mannose metabolism_Homo sapiens_hsa000511.93351086
16Selenocompound metabolism_Homo sapiens_hsa004501.89747799
17Nucleotide excision repair_Homo sapiens_hsa034201.85445440
18One carbon pool by folate_Homo sapiens_hsa006701.70280763
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68061599
20Pentose phosphate pathway_Homo sapiens_hsa000301.66680715
21Oocyte meiosis_Homo sapiens_hsa041141.64153706
22Linoleic acid metabolism_Homo sapiens_hsa005911.64132015
23RNA degradation_Homo sapiens_hsa030181.52211425
24Dorso-ventral axis formation_Homo sapiens_hsa043201.47494783
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.43088904
26Pyruvate metabolism_Homo sapiens_hsa006201.42494914
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42119835
28Antigen processing and presentation_Homo sapiens_hsa046121.41681546
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41242731
30Pyrimidine metabolism_Homo sapiens_hsa002401.39610507
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39609435
32p53 signaling pathway_Homo sapiens_hsa041151.39158550
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30254098
34Non-homologous end-joining_Homo sapiens_hsa034501.25194285
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23512940
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.17254091
37Glucagon signaling pathway_Homo sapiens_hsa049221.06354896
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.04403445
39Biosynthesis of amino acids_Homo sapiens_hsa012301.04241978
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00459775
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.99458633
42Viral carcinogenesis_Homo sapiens_hsa052030.98510082
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97043559
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93551306
45Systemic lupus erythematosus_Homo sapiens_hsa053220.92894616
46Glycerolipid metabolism_Homo sapiens_hsa005610.92894100
47Purine metabolism_Homo sapiens_hsa002300.92822824
48Herpes simplex infection_Homo sapiens_hsa051680.90311050
49Central carbon metabolism in cancer_Homo sapiens_hsa052300.90270025
50Bladder cancer_Homo sapiens_hsa052190.89893474
51Carbon metabolism_Homo sapiens_hsa012000.88197119
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87816309
53Legionellosis_Homo sapiens_hsa051340.87222040
54Glycerophospholipid metabolism_Homo sapiens_hsa005640.86973468
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83211380
56Hedgehog signaling pathway_Homo sapiens_hsa043400.82504591
57Butanoate metabolism_Homo sapiens_hsa006500.82148188
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81637957
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79083657
60Epstein-Barr virus infection_Homo sapiens_hsa051690.77286417
61Alcoholism_Homo sapiens_hsa050340.75865567
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73612492
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73458240
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73081714
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72422591
66mTOR signaling pathway_Homo sapiens_hsa041500.70613349
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70397669
68HTLV-I infection_Homo sapiens_hsa051660.68898330
69Arginine and proline metabolism_Homo sapiens_hsa003300.68813469
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68129396
71Arachidonic acid metabolism_Homo sapiens_hsa005900.67762348
72Basal cell carcinoma_Homo sapiens_hsa052170.65923613
73Galactose metabolism_Homo sapiens_hsa000520.65290717
74Cardiac muscle contraction_Homo sapiens_hsa042600.64437938
75RNA polymerase_Homo sapiens_hsa030200.63725265
76Lysine degradation_Homo sapiens_hsa003100.63593127
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63193538
78Folate biosynthesis_Homo sapiens_hsa007900.61619653
79Notch signaling pathway_Homo sapiens_hsa043300.60685241
80N-Glycan biosynthesis_Homo sapiens_hsa005100.59712132
81Small cell lung cancer_Homo sapiens_hsa052220.56733209
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56059644
83Proteasome_Homo sapiens_hsa030500.55888737
84Parkinsons disease_Homo sapiens_hsa050120.54795754
85Propanoate metabolism_Homo sapiens_hsa006400.53390450
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52425066
87AMPK signaling pathway_Homo sapiens_hsa041520.52410322
88Melanoma_Homo sapiens_hsa052180.49499963
89Phototransduction_Homo sapiens_hsa047440.47789254
90Influenza A_Homo sapiens_hsa051640.47176145
91Renin-angiotensin system_Homo sapiens_hsa046140.47067496
92Nitrogen metabolism_Homo sapiens_hsa009100.46338423
93Metabolic pathways_Homo sapiens_hsa011000.46166872
94PPAR signaling pathway_Homo sapiens_hsa033200.45692399
95Arginine biosynthesis_Homo sapiens_hsa002200.45606129
96MicroRNAs in cancer_Homo sapiens_hsa052060.45503165
97Measles_Homo sapiens_hsa051620.45161813
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.44690587
99Sulfur relay system_Homo sapiens_hsa041220.44358406
100Inositol phosphate metabolism_Homo sapiens_hsa005620.44142868
101B cell receptor signaling pathway_Homo sapiens_hsa046620.43832366
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43138582
103Oxidative phosphorylation_Homo sapiens_hsa001900.42347867
104Glutathione metabolism_Homo sapiens_hsa004800.41719287
105Ether lipid metabolism_Homo sapiens_hsa005650.41266173
106Acute myeloid leukemia_Homo sapiens_hsa052210.40316491
107VEGF signaling pathway_Homo sapiens_hsa043700.39206090
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38673837
109Insulin signaling pathway_Homo sapiens_hsa049100.37673642
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37054645
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36864170
112Non-small cell lung cancer_Homo sapiens_hsa052230.33460169
113Fatty acid elongation_Homo sapiens_hsa000620.32658544
114Other glycan degradation_Homo sapiens_hsa005110.32527924
115Huntingtons disease_Homo sapiens_hsa050160.32469682
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31595129
117HIF-1 signaling pathway_Homo sapiens_hsa040660.31526274
118Thyroid cancer_Homo sapiens_hsa052160.31165597
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30258349
120Prostate cancer_Homo sapiens_hsa052150.29984460
121ABC transporters_Homo sapiens_hsa020100.29829296
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29788957
123Chronic myeloid leukemia_Homo sapiens_hsa052200.29755085
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.29734480
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29354562
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29177184
127Hippo signaling pathway_Homo sapiens_hsa043900.28846304
128Ribosome_Homo sapiens_hsa030100.27523793
129Apoptosis_Homo sapiens_hsa042100.27330862
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26650994
131Fat digestion and absorption_Homo sapiens_hsa049750.26398632
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25783106
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25551650
134Fatty acid metabolism_Homo sapiens_hsa012120.22527704
135Endocytosis_Homo sapiens_hsa041440.22363593
136TGF-beta signaling pathway_Homo sapiens_hsa043500.22120981
137Wnt signaling pathway_Homo sapiens_hsa043100.21645516
138Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.21489092
139Adherens junction_Homo sapiens_hsa045200.21435039
140Toxoplasmosis_Homo sapiens_hsa051450.21339196
141Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18334580

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »