WDR63

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.94402928
2sperm motility (GO:0030317)9.60859394
3ventricular system development (GO:0021591)9.04413367
4piRNA metabolic process (GO:0034587)8.78766843
5axoneme assembly (GO:0035082)8.24489292
6multicellular organism reproduction (GO:0032504)8.20488483
7acrosome assembly (GO:0001675)8.17630116
8sperm-egg recognition (GO:0035036)8.14320681
9regulation of cilium movement (GO:0003352)8.06451022
10acrosome reaction (GO:0007340)7.72479081
11spermatid development (GO:0007286)7.59700921
12plasma membrane fusion (GO:0045026)7.53590705
13binding of sperm to zona pellucida (GO:0007339)7.47114200
14male meiosis (GO:0007140)7.44465604
15cell-cell recognition (GO:0009988)7.27936960
16cell wall macromolecule catabolic process (GO:0016998)7.01141662
17cell wall macromolecule metabolic process (GO:0044036)7.01141662
18synaptonemal complex organization (GO:0070193)6.77449654
19intraciliary transport (GO:0042073)6.69791082
20reproduction (GO:0000003)6.61894999
21left/right axis specification (GO:0070986)6.41624036
22synaptonemal complex assembly (GO:0007130)6.12424185
23single fertilization (GO:0007338)6.04537347
24male meiosis I (GO:0007141)5.84642102
25nucleoside diphosphate phosphorylation (GO:0006165)5.77288963
26negative regulation of inclusion body assembly (GO:0090084)5.74817862
27GTP biosynthetic process (GO:0006183)5.73862975
28protein localization to cilium (GO:0061512)5.37831970
29cilium organization (GO:0044782)5.34993155
30DNA methylation involved in gamete generation (GO:0043046)5.32447940
31microtubule severing (GO:0051013)5.30668106
32sperm capacitation (GO:0048240)5.20146641
33fertilization (GO:0009566)5.16686105
34UTP biosynthetic process (GO:0006228)5.06213157
35cilium assembly (GO:0042384)5.05761416
36cilium morphogenesis (GO:0060271)5.05408532
37spermatogenesis (GO:0007283)4.94015228
38male gamete generation (GO:0048232)4.91819954
39regulation of microtubule-based movement (GO:0060632)4.89302492
40primary alcohol catabolic process (GO:0034310)4.79504001
41meiosis I (GO:0007127)4.78923331
42microtubule-based movement (GO:0007018)4.78616349
43UTP metabolic process (GO:0046051)4.74143629
44left/right pattern formation (GO:0060972)4.60878086
45microtubule bundle formation (GO:0001578)4.54525827
46regulation of inclusion body assembly (GO:0090083)4.54138721
47pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.52805232
48gamete generation (GO:0007276)4.51991070
49cellular component assembly involved in morphogenesis (GO:0010927)4.44457040
50meiotic cell cycle (GO:0051321)4.40364987
51base-excision repair, AP site formation (GO:0006285)4.40351229
52meiotic nuclear division (GO:0007126)4.35774449
53centriole assembly (GO:0098534)4.28906245
54germ cell development (GO:0007281)4.27461705
55chromosome organization involved in meiosis (GO:0070192)4.18248504
56vitamin transmembrane transport (GO:0035461)4.14433589
57cellular process involved in reproduction in multicellular organism (GO:0022412)4.10408425
58protein polyglutamylation (GO:0018095)4.09187074
59microtubule polymerization or depolymerization (GO:0031109)4.01635266
60diterpenoid biosynthetic process (GO:0016102)4.00561975
61guanosine-containing compound biosynthetic process (GO:1901070)3.87563093
62pyrimidine-containing compound transmembrane transport (GO:0072531)3.83650136
63CTP metabolic process (GO:0046036)3.81279192
64CTP biosynthetic process (GO:0006241)3.81279192
65ethanol metabolic process (GO:0006067)3.79109952
66organic cation transport (GO:0015695)3.77975530
67pyrimidine nucleotide catabolic process (GO:0006244)3.76788131
68glomerular epithelial cell development (GO:0072310)3.71401453
69centriole replication (GO:0007099)3.70570663
70cell recognition (GO:0008037)3.57372004
71lung epithelium development (GO:0060428)3.57050852
72multicellular organismal reproductive process (GO:0048609)3.55793301
73response to xenobiotic stimulus (GO:0009410)3.50161533
74calcium ion-dependent exocytosis (GO:0017156)3.49062677
75retinal rod cell development (GO:0046548)3.45902548
76pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.44508244
77regulation of protein polyubiquitination (GO:1902914)3.42571323
78C21-steroid hormone biosynthetic process (GO:0006700)3.42476970
79establishment of tissue polarity (GO:0007164)3.40116090
80establishment of planar polarity (GO:0001736)3.40116090
81one-carbon compound transport (GO:0019755)3.37832531
82cytoplasmic microtubule organization (GO:0031122)3.36836960
83lateral ventricle development (GO:0021670)3.34872811
84cell projection assembly (GO:0030031)3.31924703
85hepatocyte differentiation (GO:0070365)3.30580397
86pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.30562655
87negative regulation of T cell differentiation in thymus (GO:0033085)3.30197496
88nonmotile primary cilium assembly (GO:0035058)3.23527058
89gene silencing by RNA (GO:0031047)3.15021166
90establishment of apical/basal cell polarity (GO:0035089)3.14799650
91protein refolding (GO:0042026)3.12846282
92regulation of meiosis I (GO:0060631)3.12321986
93seminiferous tubule development (GO:0072520)3.12301236
94pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.11590598
95negative regulation of immunoglobulin mediated immune response (GO:0002890)3.09969847
96negative regulation of B cell mediated immunity (GO:0002713)3.09969847
97genitalia morphogenesis (GO:0035112)3.09849386
98microtubule depolymerization (GO:0007019)3.09785172
99progesterone metabolic process (GO:0042448)3.07743789
100nucleotide phosphorylation (GO:0046939)3.06553129
101negative regulation of organelle assembly (GO:1902116)3.05381168
102positive regulation of smoothened signaling pathway (GO:0045880)3.04784290
103spermatid nucleus differentiation (GO:0007289)3.03716437
104terpenoid biosynthetic process (GO:0016114)3.03629932
105tolerance induction (GO:0002507)3.01683283
106negative regulation of humoral immune response (GO:0002921)2.99266568
107photoreceptor cell maintenance (GO:0045494)2.96402155
108retinoic acid metabolic process (GO:0042573)2.92757190
109nucleoside diphosphate metabolic process (GO:0009132)2.92644100
110establishment of monopolar cell polarity (GO:0061162)2.88154563
111establishment or maintenance of monopolar cell polarity (GO:0061339)2.88154563
112smoothened signaling pathway (GO:0007224)2.80994083
113heart looping (GO:0001947)2.80989399
114chaperone-mediated protein complex assembly (GO:0051131)2.80025521
115regulation of centriole replication (GO:0046599)2.79371784
116regulation of interleukin-5 production (GO:0032674)2.79302542
117negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.79164597
118determination of left/right symmetry (GO:0007368)2.79076378
119lateral sprouting from an epithelium (GO:0060601)2.78754898
120ethanol oxidation (GO:0006069)2.78743626
121pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.77257472
122microtubule-based process (GO:0007017)2.75425127
123regulation of DNA endoreduplication (GO:0032875)2.72934785
124regulation of interleukin-13 production (GO:0032656)2.71055384
125determination of bilateral symmetry (GO:0009855)2.70167970
126multicellular organismal development (GO:0007275)2.68746865
127organelle assembly (GO:0070925)2.66995849
128peptidyl-glutamic acid modification (GO:0018200)2.65693424
129embryonic camera-type eye development (GO:0031076)2.64445254
130specification of symmetry (GO:0009799)2.64320344
131embryonic heart tube morphogenesis (GO:0003143)2.57180940
132intra-S DNA damage checkpoint (GO:0031573)2.57072884
133aldehyde catabolic process (GO:0046185)2.55899518
134pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.54341389
135limb development (GO:0060173)2.54055162
136appendage development (GO:0048736)2.54055162
137meiotic cell cycle process (GO:1903046)2.52372202
138regulation of germinal center formation (GO:0002634)2.50565494
139regulation of smoothened signaling pathway (GO:0008589)2.50327166
140positive regulation of tolerance induction (GO:0002645)2.47907016
141lactate metabolic process (GO:0006089)2.47536420
142glutathione derivative metabolic process (GO:1901685)2.44270560
143glutathione derivative biosynthetic process (GO:1901687)2.44270560
144ADP metabolic process (GO:0046031)2.40280984
145apical protein localization (GO:0045176)2.39910809
146amino-acid betaine metabolic process (GO:0006577)2.39396026
147alditol metabolic process (GO:0019400)2.38087360
148regulation of collateral sprouting (GO:0048670)2.35358992
149asymmetric protein localization (GO:0008105)2.34262697
150carnitine metabolic process (GO:0009437)2.30802857
151regulation of cilium assembly (GO:1902017)2.22057443
152regulation of autophagic vacuole assembly (GO:2000785)2.18084708
153retinol metabolic process (GO:0042572)2.16529330
154cilium or flagellum-dependent cell motility (GO:0001539)17.9716446
155axonemal dynein complex assembly (GO:0070286)16.2075274
156cilium movement (GO:0003341)14.2760785
157epithelial cilium movement (GO:0003351)12.4596508
158motile cilium assembly (GO:0044458)12.0317882
159epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.7652639

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.17303547
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.90191749
3EZH2_22144423_ChIP-Seq_EOC_Human4.60571705
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.96786478
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.88859005
6PIAS1_25552417_ChIP-Seq_VCAP_Human2.43228200
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.37332545
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.37261867
9FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.25053094
10EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.13387835
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10286244
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.07306873
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.01162517
14TP53_18474530_ChIP-ChIP_U2OS_Human1.99947035
15TRIM28_21343339_ChIP-Seq_HEK293_Human1.99341510
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.93468611
17ELK4_26923725_Chip-Seq_MESODERM_Mouse1.92634454
18FUS_26573619_Chip-Seq_HEK293_Human1.87251405
19ZNF274_21170338_ChIP-Seq_K562_Hela1.86324262
20TOP2B_26459242_ChIP-Seq_MCF-7_Human1.84829915
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84372076
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83583734
23TP53_16413492_ChIP-PET_HCT116_Human1.81063937
24WDR5_24793694_ChIP-Seq_LNCAP_Human1.80355055
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75360561
26* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.74900392
27AHR_22903824_ChIP-Seq_MCF-7_Human1.69601895
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64855847
29* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59436451
30TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.56643077
31TAL1_26923725_Chip-Seq_HPCs_Mouse1.55896583
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53999795
33VDR_22108803_ChIP-Seq_LS180_Human1.53530426
34* TP63_23658742_ChIP-Seq_EP156T_Human1.52824305
35SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.52676101
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.51770472
37* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.51182522
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50108730
39GBX2_23144817_ChIP-Seq_PC3_Human1.48584691
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48257817
41CBP_20019798_ChIP-Seq_JUKART_Human1.48257817
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.47401886
43TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45727682
44CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.44732223
45RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43268846
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42393498
47RNF2_27304074_Chip-Seq_NSC_Mouse1.41882089
48SOX2_22085726_ChIP-Seq_NPCs_Mouse1.41752947
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41585850
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41465482
51KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.41390708
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39663212
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.37461713
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37113654
55TCF4_22108803_ChIP-Seq_LS180_Human1.36275862
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.35654883
57STAT1_17558387_ChIP-Seq_HELA_Human1.35302899
58* PHF8_20622853_ChIP-Seq_HELA_Human1.34772027
59FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.34704313
60MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32232959
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.31704956
62P300_19829295_ChIP-Seq_ESCs_Human1.29962051
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29249046
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26245553
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26098548
66IGF1R_20145208_ChIP-Seq_DFB_Human1.26014381
67BCAT_22108803_ChIP-Seq_LS180_Human1.24971019
68SMAD4_21799915_ChIP-Seq_A2780_Human1.22825757
69* HNFA_21074721_ChIP-Seq_CACO-2_Human1.22359175
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.22107574
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21036382
72EWS_26573619_Chip-Seq_HEK293_Human1.21010997
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20310579
74GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.19819544
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19706355
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19706355
77GF1_26923725_Chip-Seq_HPCs_Mouse1.19482643
78* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.18907347
79LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.18251476
80* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.18095502
81TAF15_26573619_Chip-Seq_HEK293_Human1.17732361
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17518405
83* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.16636932
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16433940
85REST_21632747_ChIP-Seq_MESCs_Mouse1.15508146
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.15341656
87RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15118831
88AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15011776
89KDM2B_26808549_Chip-Seq_REH_Human1.14927358
90ERG_20517297_ChIP-Seq_VCAP_Human1.14718038
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14695893
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14408725
93* ETV1_20927104_ChIP-Seq_GIST48_Human1.13720395
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13697825
95* NFYB_21822215_ChIP-Seq_K562_Human1.12128674
96* NFYA_21822215_ChIP-Seq_K562_Human1.12059617
97GATA3_21867929_ChIP-Seq_CD8_Mouse1.11061852
98* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10608783
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10540260
100FOXA1_25552417_ChIP-Seq_VCAP_Human1.10495949
101P53_22387025_ChIP-Seq_ESCs_Mouse1.10279945
102* P53_21459846_ChIP-Seq_SAOS-2_Human1.09740950
103* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09034253
104* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08938021
105ER_23166858_ChIP-Seq_MCF-7_Human1.08017684
106AR_21572438_ChIP-Seq_LNCaP_Human1.07933160
107STAT1_20625510_ChIP-Seq_HELA_Human1.07718259
108SMAD4_21741376_ChIP-Seq_EPCs_Human1.07399852
109AR_25329375_ChIP-Seq_VCAP_Human1.07215892
110SMRT_27268052_Chip-Seq_Bcells_Human1.06055126
111RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04330404
112EZH2_27294783_Chip-Seq_NPCs_Mouse1.03975477
113SALL1_21062744_ChIP-ChIP_HESCs_Human1.03951355
114* RUNX2_22187159_ChIP-Seq_PCA_Human1.03492863
115CRX_20693478_ChIP-Seq_RETINA_Mouse1.03143793
116AR_20517297_ChIP-Seq_VCAP_Human1.02570557
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02344603
118NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02104127
119* RBPJ_21746931_ChIP-Seq_IB4_Human1.01677376
120OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01446882
121* TCF4_23295773_ChIP-Seq_U87_Human1.01383184
122GF1B_26923725_Chip-Seq_HPCs_Mouse1.00517240
123* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.99953394
124RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99314601
125CDX2_22108803_ChIP-Seq_LS180_Human0.98670971
126* LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98381744
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98114368
128* OCT4_18555785_Chip-Seq_ESCs_Mouse0.97987580
129* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97835752
130JUN_21703547_ChIP-Seq_K562_Human0.97739480
131STAT3_23295773_ChIP-Seq_U87_Human0.97604784
132STAT3_18555785_Chip-Seq_ESCs_Mouse0.97148066
133TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96351093
134NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96293971
135NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96293971
136FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95871600
137EZH2_27294783_Chip-Seq_ESCs_Mouse0.95381978
138CBP_21632823_ChIP-Seq_H3396_Human0.95295349
139CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95288076
140EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95097476
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93782914
142E2F1_18555785_Chip-Seq_ESCs_Mouse0.93166783
143FOXA1_25329375_ChIP-Seq_VCAP_Human0.93079527
144FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93079527
145AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92861736
146EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92147965
147DROSHA_22980978_ChIP-Seq_HELA_Human0.91607690
148* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.91575371
149KLF4_18555785_Chip-Seq_ESCs_Mouse0.91503350
150KLF5_25053715_ChIP-Seq_YYC3_Human0.91248095
151ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91196142
152STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.90969269
153* GATA6_21074721_ChIP-Seq_CACO-2_Human0.90193685
154CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89802941
155* CMYC_18555785_Chip-Seq_ESCs_Mouse0.89238250
156* P300_18555785_Chip-Seq_ESCs_Mouse0.89037671
157ZFX_18555785_Chip-Seq_ESCs_Mouse0.88961748
158TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88624450
159EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.88372637
160SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88048192
161PU1_27457419_Chip-Seq_LIVER_Mouse0.87872597
162* TBL1_22424771_ChIP-Seq_293T_Human0.87487702
163SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.87259713

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.22635803
2MP0002653_abnormal_ependyma_morphology4.99501917
3MP0001929_abnormal_gametogenesis4.79469407
4MP0008877_abnormal_DNA_methylation4.08847136
5MP0008004_abnormal_stomach_pH3.61603574
6MP0002210_abnormal_sex_determination3.40411522
7MP0005623_abnormal_meninges_morphology3.20242104
8MP0005171_absent_coat_pigmentation3.09363059
9MP0002160_abnormal_reproductive_system3.03752215
10MP0000566_synostosis3.02721614
11MP0008789_abnormal_olfactory_epithelium2.85531466
12MP0002161_abnormal_fertility/fecundity2.82132118
13MP0001145_abnormal_male_reproductive2.81544362
14MP0003136_yellow_coat_color2.76062544
15MP0000653_abnormal_sex_gland2.51157841
16MP0003011_delayed_dark_adaptation2.40200426
17MP0001984_abnormal_olfaction2.34778612
18MP0005647_abnormal_sex_gland2.24797055
19MP0002928_abnormal_bile_duct2.18757041
20MP0004133_heterotaxia2.12323936
21MP0000383_abnormal_hair_follicle2.09565837
22MP0002277_abnormal_respiratory_mucosa2.02764298
23MP0005248_abnormal_Harderian_gland2.01642425
24MP0005410_abnormal_fertilization12.2052894
25MP0004043_abnormal_pH_regulation1.99994023
26MP0005394_taste/olfaction_phenotype1.90198980
27MP0005499_abnormal_olfactory_system1.90198980
28MP0002282_abnormal_trachea_morphology1.85063875
29MP0001485_abnormal_pinna_reflex1.77416174
30MP0010678_abnormal_skin_adnexa1.71908378
31MP0008057_abnormal_DNA_replication1.68310709
32MP0010030_abnormal_orbit_morphology1.67398118
33MP0005389_reproductive_system_phenotype1.62793994
34MP0005408_hypopigmentation1.47942721
35MP0000026_abnormal_inner_ear1.43044522
36MP0002233_abnormal_nose_morphology1.38205796
37MP0001958_emphysema1.29850263
38MP0009046_muscle_twitch1.26682362
39MP0005646_abnormal_pituitary_gland1.25338271
40MP0003950_abnormal_plasma_membrane1.24729861
41MP0008995_early_reproductive_senescence1.24062725
42MP0005174_abnormal_tail_pigmentation1.23868899
43MP0000372_irregular_coat_pigmentation1.23056024
44MP0005670_abnormal_white_adipose1.22231635
45MP0001299_abnormal_eye_distance/1.21757801
46MP0005083_abnormal_biliary_tract1.18543276
47MP0002909_abnormal_adrenal_gland1.16616206
48MP0005551_abnormal_eye_electrophysiolog1.12519550
49MP0003937_abnormal_limbs/digits/tail_de1.11719506
50MP0000678_abnormal_parathyroid_gland1.10906163
51MP0005503_abnormal_tendon_morphology1.10814783
52MP0000569_abnormal_digit_pigmentation1.07640816
53MP0003878_abnormal_ear_physiology1.05249191
54MP0005377_hearing/vestibular/ear_phenot1.05249191
55MP0005395_other_phenotype1.03557472
56MP0006072_abnormal_retinal_apoptosis0.99004016
57MP0001765_abnormal_ion_homeostasis0.98190613
58MP0008058_abnormal_DNA_repair0.97899802
59MP0003942_abnormal_urinary_system0.95690909
60MP0000049_abnormal_middle_ear0.91219358
61MP0002234_abnormal_pharynx_morphology0.89835074
62MP0003646_muscle_fatigue0.86648307
63MP0002133_abnormal_respiratory_system0.86085031
64MP0005388_respiratory_system_phenotype0.86085031
65MP0005220_abnormal_exocrine_pancreas0.85458413
66MP0004019_abnormal_vitamin_homeostasis0.85187376
67MP0001963_abnormal_hearing_physiology0.85085760
68MP0003879_abnormal_hair_cell0.83685771
69MP0004782_abnormal_surfactant_physiolog0.82482456
70MP0005253_abnormal_eye_physiology0.82319209
71MP0004134_abnormal_chest_morphology0.82292783
72MP0005508_abnormal_skeleton_morphology0.80888952
73MP0002139_abnormal_hepatobiliary_system0.80710628
74MP0010368_abnormal_lymphatic_system0.79385116
75MP0001270_distended_abdomen0.77505654
76MP0002095_abnormal_skin_pigmentation0.76984202
77MP0001346_abnormal_lacrimal_gland0.76325673
78MP0003115_abnormal_respiratory_system0.71353863
79MP0000955_abnormal_spinal_cord0.71023009
80MP0001851_eye_inflammation0.69021789
81MP0004885_abnormal_endolymph0.68651826
82MP0003656_abnormal_erythrocyte_physiolo0.68039127
83MP0003943_abnormal_hepatobiliary_system0.67321145
84MP0001440_abnormal_grooming_behavior0.66772999
85MP0001177_atelectasis0.65587309
86MP0003786_premature_aging0.64929595
87MP0002168_other_aberrant_phenotype0.63145332
88MP0000432_abnormal_head_morphology0.62569496
89MP0001873_stomach_inflammation0.61265694
90MP0004233_abnormal_muscle_weight0.61015447
91MP0005391_vision/eye_phenotype0.60308180
92MP0002752_abnormal_somatic_nervous0.59753551
93MP0002084_abnormal_developmental_patter0.57799634
94MP0001324_abnormal_eye_pigmentation0.57637696
95MP0003634_abnormal_glial_cell0.57626677
96MP0008875_abnormal_xenobiotic_pharmacok0.55621977
97MP0002896_abnormal_bone_mineralization0.55529333
98MP0003938_abnormal_ear_development0.53853855
99MP0000534_abnormal_ureter_morphology0.52416862
100MP0003718_maternal_effect0.52399671
101MP0009703_decreased_birth_body0.51736122
102MP0000762_abnormal_tongue_morphology0.50851388
103MP0000015_abnormal_ear_pigmentation0.49464612
104MP0005636_abnormal_mineral_homeostasis0.48829991
105MP0002735_abnormal_chemical_nociception0.48702975
106MP0000681_abnormal_thyroid_gland0.48480105
107MP0003755_abnormal_palate_morphology0.48294423
108MP0002822_catalepsy0.48292941
109MP0000647_abnormal_sebaceous_gland0.47338600
110MP0009053_abnormal_anal_canal0.46795997
111MP0001293_anophthalmia0.46479544
112MP0009379_abnormal_foot_pigmentation0.45407051
113MP0002295_abnormal_pulmonary_circulatio0.45398881
114MP0002152_abnormal_brain_morphology0.44798187
115MP0001119_abnormal_female_reproductive0.44031494
116MP0003861_abnormal_nervous_system0.43836420
117MP0000358_abnormal_cell_content/0.42928990
118MP0002876_abnormal_thyroid_physiology0.42623026
119MP0003633_abnormal_nervous_system0.42606167
120MP0000778_abnormal_nervous_system0.42251169
121MP0005195_abnormal_posterior_eye0.41453229
122MP0005666_abnormal_adipose_tissue0.41417236
123MP0002249_abnormal_larynx_morphology0.41137276
124MP0009115_abnormal_fat_cell0.40414325
125MP0002132_abnormal_respiratory_system0.40358413
126MP0004381_abnormal_hair_follicle0.40326498
127MP0002557_abnormal_social/conspecific_i0.40136489
128MP0001879_abnormal_lymphatic_vessel0.39727128
129MP0003699_abnormal_female_reproductive0.39621513
130MP0002736_abnormal_nociception_after0.38434897
131MP0000613_abnormal_salivary_gland0.37724485
132MP0005365_abnormal_bile_salt0.36662910
133MP0002108_abnormal_muscle_morphology0.36569826
134MP0002734_abnormal_mechanical_nocicepti0.36233440
135MP0009780_abnormal_chondrocyte_physiolo0.36105530
136MP0002938_white_spotting0.35855167
137MP0003045_fibrosis0.35494609
138MP0002971_abnormal_brown_adipose0.35247045
139MP0000013_abnormal_adipose_tissue0.34967578
140MP0002405_respiratory_system_inflammati0.34470043
141MP0001764_abnormal_homeostasis0.33904324
142MP0001545_abnormal_hematopoietic_system0.33672852
143MP0005397_hematopoietic_system_phenotyp0.33672852
144MP0010329_abnormal_lipoprotein_level0.32706514
145MP0002116_abnormal_craniofacial_bone0.31326882
146MP0003890_abnormal_embryonic-extraembry0.30397597
147MP0000470_abnormal_stomach_morphology0.29798977
148MP0002092_abnormal_eye_morphology0.29716463
149MP0005167_abnormal_blood-brain_barrier0.29597038
150MP0002638_abnormal_pupillary_reflex0.29346497
151MP0000631_abnormal_neuroendocrine_gland0.28745386
152MP0002109_abnormal_limb_morphology0.28739911
153MP0002229_neurodegeneration0.28692505
154MP0009384_cardiac_valve_regurgitation0.28581451

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.43231790
2Abnormal respiratory epithelium morphology (HP:0012253)9.08013495
3Abnormal respiratory motile cilium morphology (HP:0005938)9.08013495
4Chronic bronchitis (HP:0004469)7.85738672
5Nasal polyposis (HP:0100582)6.04882849
6Bronchiectasis (HP:0002110)5.54541811
7Infertility (HP:0000789)5.30116488
8Abnormality of the nasal mucosa (HP:0000433)5.06943184
9Bronchitis (HP:0012387)4.24230813
10Male infertility (HP:0003251)4.22196551
11Atelectasis (HP:0100750)3.64643563
12Tubulointerstitial nephritis (HP:0001970)3.64635637
13Nephronophthisis (HP:0000090)3.61760615
14Pancreatic fibrosis (HP:0100732)3.31840425
15Medial flaring of the eyebrow (HP:0010747)3.21701735
16True hermaphroditism (HP:0010459)3.21699603
17Recurrent sinusitis (HP:0011108)3.15434924
18Recurrent otitis media (HP:0000403)3.03110899
19Supernumerary spleens (HP:0009799)2.99982714
20Occipital encephalocele (HP:0002085)2.95860885
21Bile duct proliferation (HP:0001408)2.93146015
22Abnormal biliary tract physiology (HP:0012439)2.93146015
23Molar tooth sign on MRI (HP:0002419)2.89718796
24Abnormality of midbrain morphology (HP:0002418)2.89718796
25Chronic otitis media (HP:0000389)2.81591171
26Chronic sinusitis (HP:0011109)2.75570615
27Abnormality of the renal medulla (HP:0100957)2.74486186
28Postaxial foot polydactyly (HP:0001830)2.73209670
29Abnormality of dentin (HP:0010299)2.71509854
30Cystic liver disease (HP:0006706)2.71307829
31Gait imbalance (HP:0002141)2.58429805
32Congenital primary aphakia (HP:0007707)2.57786351
33Tubulointerstitial abnormality (HP:0001969)2.52895065
34Congenital hepatic fibrosis (HP:0002612)2.45196280
35Pancreatic cysts (HP:0001737)2.43992325
36Abnormality of the lower motor neuron (HP:0002366)2.35569721
37Aplasia/Hypoplasia of the tongue (HP:0010295)2.33810252
38Fibular hypoplasia (HP:0003038)2.32403823
39Abnormality of permanent molar morphology (HP:0011071)2.31777728
40Abnormality of the dental root (HP:0006486)2.31777728
41Taurodontia (HP:0000679)2.31777728
42Median cleft lip (HP:0000161)2.30910878
43Tubular atrophy (HP:0000092)2.28522161
44Nephrogenic diabetes insipidus (HP:0009806)2.26604586
45Abnormality of molar morphology (HP:0011070)2.19097179
46Abnormality of molar (HP:0011077)2.19097179
47Abnormality of the dental pulp (HP:0006479)2.10645830
48Broad distal phalanx of finger (HP:0009836)2.06165904
49Poor coordination (HP:0002370)2.00161316
50Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.7659827
51Abnormal respiratory motile cilium physiology (HP:0012261)11.5585988
52Absent/shortened dynein arms (HP:0200106)10.3091387
53Dynein arm defect of respiratory motile cilia (HP:0012255)10.3091387
54Abnormal ciliary motility (HP:0012262)10.2099113
55Oculomotor apraxia (HP:0000657)1.97050911
56Genital tract atresia (HP:0001827)1.96332780
57Chronic hepatic failure (HP:0100626)1.96039513
58Stage 5 chronic kidney disease (HP:0003774)1.95124586
59Male pseudohermaphroditism (HP:0000037)1.93116907
60Vaginal atresia (HP:0000148)1.90913597
61Postaxial hand polydactyly (HP:0001162)1.90390125
62Recurrent bronchitis (HP:0002837)1.83225574
63Amyotrophic lateral sclerosis (HP:0007354)1.79817614
64Degeneration of the lateral corticospinal tracts (HP:0002314)1.79351123
65Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79351123
66Hyperactive renin-angiotensin system (HP:0000841)1.77836744
67Facial cleft (HP:0002006)1.74960156
68Tubulointerstitial fibrosis (HP:0005576)1.71852808
69Anencephaly (HP:0002323)1.69418874
70Short nail (HP:0001799)1.59315825
71Aplasia/Hypoplasia of the lens (HP:0008063)1.58757500
72Absent frontal sinuses (HP:0002688)1.57619836
73Abnormality of the renal cortex (HP:0011035)1.57167954
74Preaxial hand polydactyly (HP:0001177)1.56846357
75Decreased circulating renin level (HP:0003351)1.48797633
76Gonadotropin excess (HP:0000837)1.47592232
77Polydipsia (HP:0001959)1.46910524
78Abnormal drinking behavior (HP:0030082)1.46910524
79Sclerocornea (HP:0000647)1.44958647
80Aplasia/Hypoplasia of the spleen (HP:0010451)1.42968818
81Asplenia (HP:0001746)1.41543793
82Furrowed tongue (HP:0000221)1.40913203
83Short ribs (HP:0000773)1.39964735
84Aplasia/Hypoplasia of the fibula (HP:0006492)1.38896667
85Back pain (HP:0003418)1.37931386
86Bell-shaped thorax (HP:0001591)1.36994993
87Nephropathy (HP:0000112)1.36601070
88Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.34479045
89Narrow forehead (HP:0000341)1.28475462
90Abnormal spermatogenesis (HP:0008669)1.26967905
91Abnormality of the corticospinal tract (HP:0002492)1.26724879
92Renal dysplasia (HP:0000110)1.26677125
93Genetic anticipation (HP:0003743)1.26642798
94Abnormality of the fetal cardiovascular system (HP:0010948)1.26476808
95Abnormal umbilical cord blood vessels (HP:0011403)1.26476808
96Single umbilical artery (HP:0001195)1.26476808
97Upper motor neuron abnormality (HP:0002127)1.25413320
98Short thorax (HP:0010306)1.25349304
99Abnormality of renal excretion (HP:0011036)1.24167491
100Aganglionic megacolon (HP:0002251)1.24006268
101Impulsivity (HP:0100710)1.23022559
102Prominent nasal bridge (HP:0000426)1.22739904
103Impaired proprioception (HP:0010831)1.22492238
104Bifid tongue (HP:0010297)1.22268989
105Renal salt wasting (HP:0000127)1.19354423
106Microglossia (HP:0000171)1.17141303
10711 pairs of ribs (HP:0000878)1.16220266
108Retinitis pigmentosa (HP:0000510)1.16220200
109Hypodontia (HP:0000668)1.14879616
110Decreased testicular size (HP:0008734)1.13416126
111Hyperaldosteronism (HP:0000859)1.13340215
112Broad foot (HP:0001769)1.13285900
113Polycystic kidney dysplasia (HP:0000113)1.12702276
114Multicystic kidney dysplasia (HP:0000003)1.12624059
115Highly arched eyebrow (HP:0002553)1.06219585
116Abnormality of macular pigmentation (HP:0008002)1.04954259
117Abnormality of the frontal sinuses (HP:0002687)1.04923625
118Holoprosencephaly (HP:0001360)1.04765816
119Intellectual disability, moderate (HP:0002342)1.04565183
120Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.02983051
121Cone-rod dystrophy (HP:0000548)1.02305341
122Bifid scrotum (HP:0000048)1.01669762
123Absent rod-and cone-mediated responses on ERG (HP:0007688)0.98270280
124Polyuria (HP:0000103)0.97680301
125Full cheeks (HP:0000293)0.95780455

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.75429786
2PDK47.75429786
3MAPK155.43643927
4PDK25.00075557
5PNCK4.90422400
6TESK13.97320902
7EPHA22.95231473
8PRKD32.81171069
9ICK2.53029055
10PTK2B2.46322229
11WNK42.24466842
12STK392.14357864
13EPHA31.92140490
14GRK11.87103310
15FER1.80412074
16MAP3K21.63822770
17WEE11.43465573
18TSSK61.35667223
19TLK11.28260691
20EEF2K1.26310989
21NME11.25378959
22NEK21.21331029
23INSRR1.21242260
24MAP3K41.19271272
25EPHB11.17001774
26PLK21.12819491
27PBK1.12360875
28CDK191.11588484
29WNK11.07309774
30PAK31.02552255
31PRKCI0.99533511
32PIM20.99220649
33CAMK1G0.95749255
34FRK0.91900616
35MAP3K30.91320756
36DYRK1B0.90502890
37STK380.88920041
38ERBB30.87813220
39MET0.86548112
40STK30.81103553
41LRRK20.81096309
42STK160.80748029
43PINK10.78003758
44CDC42BPA0.77801126
45BCKDK0.77228777
46LMTK20.74622397
47PRKCG0.74482814
48MAP3K120.74130290
49IRAK10.73094090
50DDR20.67235142
51MAPKAPK30.66484680
52NTRK20.64725170
53PASK0.64007196
54STK38L0.62863360
55PDK10.62415624
56PTK60.62074032
57MAPKAPK50.61963482
58ERBB20.60295336
59MAP4K20.59887836
60MARK30.55687974
61TYRO30.53625039
62DYRK30.53407735
63BMPR20.50981438
64CDC70.49727577
65LIMK10.47458131
66NEK60.46942345
67BCR0.46936393
68RPS6KA50.44706622
69MAP3K50.44070562
70CCNB10.41892255
71CDK120.41548684
72CAMKK10.40384219
73WNK30.39994572
74PAK20.39120148
75MUSK0.38560567
76TTK0.38023469
77NLK0.37996514
78MAP2K10.37816598
79DYRK1A0.37685593
80FGFR10.36592416
81CHUK0.36118646
82AKT20.34492794
83CSNK1G20.33978744
84LATS10.32863090
85BRSK20.32211930
86PLK40.32055307
87CHEK20.31399070
88RPS6KA20.30299785
89VRK10.30282816
90ROCK20.29375457
91CDK90.29318701
92MAP3K70.28938710
93MST1R0.28727035
94OXSR10.27981820
95PRKCD0.27465893
96ABL10.27187916
97MAPK130.25815522
98TRPM70.24866211
99CHEK10.24846711
100TNIK0.24835586
101ATM0.24191834
102ADRBK20.23610975
103TGFBR20.23349041
104STK100.23145554
105MYLK0.22957422
106RIPK10.22903146
107CASK0.22118792
108TRIM280.22000909
109EPHB20.21996368
110SMG10.21993770
111RPS6KB10.21413014
112MST40.21313940
113CAMK2G0.21125122
114PRKCQ0.20772718
115GRK70.20419289
116PRKG10.18759973
117PDPK10.18668932
118CSK0.18585036
119PRKACG0.16530065
120PRKAA10.16409248
121PIK3CG0.16390149
122PRKDC0.16372526
123MTOR0.16062195
124CDK30.14677272
125GSK3A0.14374703
126AURKA0.14189339
127MARK10.13145038
128ATR0.12595676
129PAK10.11813954
130SIK10.11664968
131BMPR1B0.11527388
132CAMK2A0.10082168
133IRAK20.09807105
134PLK10.09586180
135RPS6KA10.09225318
136PRKCE0.09204137
137BRSK10.08894963
138MAPK80.08725113
139PRKG20.08213049
140SRC0.08195246
141PRKCZ0.07944884
142NEK90.07888431
143CSNK1E0.07009495
144STK240.06949636
145RPS6KA30.06739005
146PAK40.06718644
147PRKACA0.06554788
148CSNK2A10.06553713
149PRKCB0.04390885
150ROCK10.04305315
151PRKCA0.03976666
152PTK20.03592896
153MAP2K70.03105110

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.85269013
2Pyruvate metabolism_Homo sapiens_hsa006203.89507456
3Phenylalanine metabolism_Homo sapiens_hsa003603.76951701
4Propanoate metabolism_Homo sapiens_hsa006403.45816020
5Tyrosine metabolism_Homo sapiens_hsa003503.24808209
6Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.15587144
7Huntingtons disease_Homo sapiens_hsa050163.02304322
8beta-Alanine metabolism_Homo sapiens_hsa004102.66837838
9Fatty acid biosynthesis_Homo sapiens_hsa000612.48336944
10Dorso-ventral axis formation_Homo sapiens_hsa043202.42340213
11Glucagon signaling pathway_Homo sapiens_hsa049222.28641930
12Fanconi anemia pathway_Homo sapiens_hsa034602.18507494
13PPAR signaling pathway_Homo sapiens_hsa033201.91577270
14Selenocompound metabolism_Homo sapiens_hsa004501.86401190
15Glycerolipid metabolism_Homo sapiens_hsa005611.85570529
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.79417732
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.78851466
18Linoleic acid metabolism_Homo sapiens_hsa005911.71534099
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69635202
20Caffeine metabolism_Homo sapiens_hsa002321.61159583
21Amphetamine addiction_Homo sapiens_hsa050311.53225610
22Basal transcription factors_Homo sapiens_hsa030221.52750007
23Pentose phosphate pathway_Homo sapiens_hsa000301.52504214
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.51991891
25Protein export_Homo sapiens_hsa030601.50429791
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.46103017
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43234322
28Ovarian steroidogenesis_Homo sapiens_hsa049131.42002540
29Olfactory transduction_Homo sapiens_hsa047401.40436239
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38201817
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31996661
32Mineral absorption_Homo sapiens_hsa049781.31767773
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.29652386
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.29250202
35Oocyte meiosis_Homo sapiens_hsa041141.28987040
36Glutathione metabolism_Homo sapiens_hsa004801.25861308
37Glycerophospholipid metabolism_Homo sapiens_hsa005641.21411222
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.20931924
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20783968
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20772263
41Chemical carcinogenesis_Homo sapiens_hsa052041.20127931
42Carbon metabolism_Homo sapiens_hsa012001.19673017
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.19497142
44Ether lipid metabolism_Homo sapiens_hsa005651.18933959
45Steroid biosynthesis_Homo sapiens_hsa001001.16339614
46Renin secretion_Homo sapiens_hsa049241.15234439
47Retinol metabolism_Homo sapiens_hsa008301.13609597
48Oxidative phosphorylation_Homo sapiens_hsa001901.12900002
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11915248
50Purine metabolism_Homo sapiens_hsa002301.11780902
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.05874763
52Circadian rhythm_Homo sapiens_hsa047101.05669614
53Hedgehog signaling pathway_Homo sapiens_hsa043401.04543008
54Fatty acid degradation_Homo sapiens_hsa000710.99728332
55Fatty acid metabolism_Homo sapiens_hsa012120.99556825
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98832659
57Phototransduction_Homo sapiens_hsa047440.93680340
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.91539562
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88811503
60Antigen processing and presentation_Homo sapiens_hsa046120.88115880
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88008028
62Alcoholism_Homo sapiens_hsa050340.87012717
63Cardiac muscle contraction_Homo sapiens_hsa042600.86930684
64Collecting duct acid secretion_Homo sapiens_hsa049660.85851490
65Nicotine addiction_Homo sapiens_hsa050330.84282740
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84252976
67Estrogen signaling pathway_Homo sapiens_hsa049150.83814096
68Sulfur metabolism_Homo sapiens_hsa009200.83723176
69Fat digestion and absorption_Homo sapiens_hsa049750.82554405
70ABC transporters_Homo sapiens_hsa020100.81881133
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.81323794
72Arachidonic acid metabolism_Homo sapiens_hsa005900.81305217
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77421166
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.76912934
75Tight junction_Homo sapiens_hsa045300.75223822
76Insulin secretion_Homo sapiens_hsa049110.75200839
77Salivary secretion_Homo sapiens_hsa049700.69516066
78Bile secretion_Homo sapiens_hsa049760.69329815
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68729849
80Butanoate metabolism_Homo sapiens_hsa006500.68413439
81Nucleotide excision repair_Homo sapiens_hsa034200.67217989
82Thyroid hormone synthesis_Homo sapiens_hsa049180.66361793
83Fructose and mannose metabolism_Homo sapiens_hsa000510.64192361
84TGF-beta signaling pathway_Homo sapiens_hsa043500.62522464
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62228181
86Calcium signaling pathway_Homo sapiens_hsa040200.60975960
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59755264
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59500609
89Nitrogen metabolism_Homo sapiens_hsa009100.58403681
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57935808
91Gastric acid secretion_Homo sapiens_hsa049710.56058912
92Basal cell carcinoma_Homo sapiens_hsa052170.55050922
93p53 signaling pathway_Homo sapiens_hsa041150.54452901
94Synaptic vesicle cycle_Homo sapiens_hsa047210.54325431
95Arginine and proline metabolism_Homo sapiens_hsa003300.53628016
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51957119
97Notch signaling pathway_Homo sapiens_hsa043300.51366295
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50079963
99Parkinsons disease_Homo sapiens_hsa050120.50035944
100Adherens junction_Homo sapiens_hsa045200.48842548
101Cocaine addiction_Homo sapiens_hsa050300.48783515
102Metabolic pathways_Homo sapiens_hsa011000.47751895
103Biosynthesis of amino acids_Homo sapiens_hsa012300.47629068
104Complement and coagulation cascades_Homo sapiens_hsa046100.47380721
105Peroxisome_Homo sapiens_hsa041460.47019458
106Circadian entrainment_Homo sapiens_hsa047130.46871052
107Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46846235
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45947303
109Vibrio cholerae infection_Homo sapiens_hsa051100.45114976
110Axon guidance_Homo sapiens_hsa043600.44960195
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44214873
112Long-term potentiation_Homo sapiens_hsa047200.44125232
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43893079
114Alzheimers disease_Homo sapiens_hsa050100.43809166
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43688564
116Wnt signaling pathway_Homo sapiens_hsa043100.43596736
117Pyrimidine metabolism_Homo sapiens_hsa002400.43300695
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43013833
119Taste transduction_Homo sapiens_hsa047420.42203869
120cAMP signaling pathway_Homo sapiens_hsa040240.40281214
121Inositol phosphate metabolism_Homo sapiens_hsa005620.39307805
122Starch and sucrose metabolism_Homo sapiens_hsa005000.38784353
123Sphingolipid metabolism_Homo sapiens_hsa006000.38319741
124Hippo signaling pathway_Homo sapiens_hsa043900.37098476
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.36545818
126AMPK signaling pathway_Homo sapiens_hsa041520.34491419
127Lysosome_Homo sapiens_hsa041420.33855796
128Histidine metabolism_Homo sapiens_hsa003400.32685384
129ECM-receptor interaction_Homo sapiens_hsa045120.32104711
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31297259
131Phagosome_Homo sapiens_hsa041450.27767894
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.26115480
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24088443
134Melanogenesis_Homo sapiens_hsa049160.23517737
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23416495
136Glutamatergic synapse_Homo sapiens_hsa047240.23299485
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21961851
138Tryptophan metabolism_Homo sapiens_hsa003800.21944226
139Systemic lupus erythematosus_Homo sapiens_hsa053220.19964338
140Adipocytokine signaling pathway_Homo sapiens_hsa049200.19584260
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19314320
142N-Glycan biosynthesis_Homo sapiens_hsa005100.19259948
143Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19157647
144Fatty acid elongation_Homo sapiens_hsa000620.18703478
145Folate biosynthesis_Homo sapiens_hsa007900.18562823
146Choline metabolism in cancer_Homo sapiens_hsa052310.18401825

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