WDR66

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein encoded by this gene belongs to the WD repeat-containing family of proteins, which function in the formation of protein-protein complexes in a variety of biological pathways. This family member appears to function in the determination of mean platelet volume (MPV), and polymorphisms in this gene have been associated with variance in MPV. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spindle assembly involved in mitosis (GO:0090307)8.11423367
2cilium or flagellum-dependent cell motility (GO:0001539)7.64397173
3response to lipoprotein particle (GO:0055094)7.50021662
4positive regulation of inositol phosphate biosynthetic process (GO:0060732)6.75050443
5negative regulation of telomerase activity (GO:0051974)6.70001025
6positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)6.34832327
7microtubule cytoskeleton organization involved in mitosis (GO:1902850)6.20677853
8prostate gland growth (GO:0060736)6.11585022
9DNA deamination (GO:0045006)6.04207067
10axonemal dynein complex assembly (GO:0070286)5.99838642
11regulation of tight junction assembly (GO:2000810)5.92178166
12mitochondrion morphogenesis (GO:0070584)5.78017928
13centrosome duplication (GO:0051298)5.74941861
14cell differentiation involved in embryonic placenta development (GO:0060706)5.71386110
15lung-associated mesenchyme development (GO:0060484)5.69736046
16positive regulation of oligodendrocyte differentiation (GO:0048714)5.66377948
17anterior/posterior axis specification, embryo (GO:0008595)5.66144646
18regulation of cell proliferation involved in kidney development (GO:1901722)5.57445472
19negative regulation of Rho protein signal transduction (GO:0035024)5.52004959
20inner cell mass cell proliferation (GO:0001833)5.47107629
21peripheral nervous system axon ensheathment (GO:0032292)5.37757721
22myelination in peripheral nervous system (GO:0022011)5.37757721
23positive regulation of fatty acid oxidation (GO:0046321)5.21270416
24NADH dehydrogenase complex assembly (GO:0010257)5.17323537
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.17323537
26mitochondrial respiratory chain complex I assembly (GO:0032981)5.17323537
27regulation of telomerase activity (GO:0051972)5.04033502
28regulation of inositol phosphate biosynthetic process (GO:0010919)5.02375519
29motile cilium assembly (GO:0044458)5.00267681
30regulation of syncytium formation by plasma membrane fusion (GO:0060142)4.94364393
31positive regulation of mitochondrial fission (GO:0090141)4.92414209
32piRNA metabolic process (GO:0034587)4.81848579
33regulation of sequestering of triglyceride (GO:0010889)4.81529639
34regulation of energy homeostasis (GO:2000505)4.80170961
35white fat cell differentiation (GO:0050872)4.79482737
36mitochondrial fusion (GO:0008053)4.75379665
37negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.72946637
38gland morphogenesis (GO:0022612)4.66903712
39cilium movement (GO:0003341)4.66576075
40epithelial cilium movement (GO:0003351)4.52470085
41serine family amino acid catabolic process (GO:0009071)4.52269057
42cellular response to lithium ion (GO:0071285)4.51288576
43negative regulation of acute inflammatory response (GO:0002674)4.49608131
44negative regulation of kidney development (GO:0090185)4.46079634
45positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.43765273
46response to caffeine (GO:0031000)4.35584928
47multicellular organism reproduction (GO:0032504)4.21557794
48somite development (GO:0061053)4.19796720
49centriole assembly (GO:0098534)4.18995418
50daunorubicin metabolic process (GO:0044597)4.16953608
51polyketide metabolic process (GO:0030638)4.16953608
52doxorubicin metabolic process (GO:0044598)4.16953608
53embryonic camera-type eye development (GO:0031076)4.08141769
54negative regulation of DNA biosynthetic process (GO:2000279)4.07245189
55superoxide anion generation (GO:0042554)4.06097776
56epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.04949217
57negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.01829048
58cell proliferation in forebrain (GO:0021846)3.99881059
59DNA methylation involved in gamete generation (GO:0043046)3.98802843
60regulation of cholesterol storage (GO:0010885)3.92165963
61peroxisome fission (GO:0016559)3.88807432
62protein complex biogenesis (GO:0070271)3.87100655
63ventricular septum development (GO:0003281)3.85066706
64CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.85061527
65acrosome reaction (GO:0007340)3.83604560
66male meiosis (GO:0007140)3.77752380
67fusion of sperm to egg plasma membrane (GO:0007342)3.75880874
68spinal cord development (GO:0021510)3.73129730
69mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.71298952
70centriole replication (GO:0007099)3.71016786
71regulation of mitochondrial fission (GO:0090140)3.70845927
72calcium-mediated signaling using intracellular calcium source (GO:0035584)3.68846982
73protein kinase C signaling (GO:0070528)3.67649522
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.65554657
75T cell lineage commitment (GO:0002360)3.63887301
76lipoprotein transport (GO:0042953)3.61991011
77energy homeostasis (GO:0097009)3.61799864
78sulfation (GO:0051923)3.56380212
79microtubule depolymerization (GO:0007019)3.52843509
80glycine metabolic process (GO:0006544)3.52311660
81mitochondrial respiratory chain complex assembly (GO:0033108)3.51759750
82purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.50419781
833-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.50419781
84lateral sprouting from an epithelium (GO:0060601)3.48972654
85sperm motility (GO:0030317)3.48681684
86flavonoid metabolic process (GO:0009812)3.33624708
87regulation of collateral sprouting (GO:0048670)3.30178937
88regulation of hematopoietic progenitor cell differentiation (GO:1901532)3.29744478
89axoneme assembly (GO:0035082)3.29007656
90intraciliary transport (GO:0042073)3.26484526
91cell wall macromolecule metabolic process (GO:0044036)3.23024351
92cell wall macromolecule catabolic process (GO:0016998)3.23024351
93regulation of female receptivity (GO:0045924)3.19015811
94positive regulation of glomerulus development (GO:0090193)3.18785299
95organ growth (GO:0035265)3.18644336
96male meiosis I (GO:0007141)3.16940080
97regulation of cilium movement (GO:0003352)3.15620323
98mesenchymal cell differentiation involved in kidney development (GO:0072161)3.15306354
99mesenchymal cell differentiation involved in renal system development (GO:2001012)3.15306354
100acrosome assembly (GO:0001675)3.14750976
101cilium assembly (GO:0042384)3.13401535
102negative regulation of DNA-dependent DNA replication (GO:2000104)3.10778760
103cilium organization (GO:0044782)3.09382240
104negative regulation of TOR signaling (GO:0032007)3.09293521
105peristalsis (GO:0030432)3.08149339
106negative regulation of synaptic transmission, GABAergic (GO:0032229)3.05429035
107regulation of mesoderm development (GO:2000380)3.05033567
108single fertilization (GO:0007338)3.04648107
109regulation of receptor binding (GO:1900120)3.03875546
110protein localization to cilium (GO:0061512)3.03506037
111DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.02646826
112TOR signaling (GO:0031929)3.01710582
113sperm-egg recognition (GO:0035036)3.01523982
114lymphangiogenesis (GO:0001946)2.98711221
115negative regulation of lipid storage (GO:0010888)2.98529554
116behavioral response to nicotine (GO:0035095)2.98347665
117regulation of transcription involved in cell fate commitment (GO:0060850)2.96378652
118kinetochore assembly (GO:0051382)2.93549552
119startle response (GO:0001964)2.92474720
120spermatid development (GO:0007286)2.91337042
121negative regulation of mast cell activation (GO:0033004)2.90487129
122positive regulation of gliogenesis (GO:0014015)2.88166748
123photoreceptor cell maintenance (GO:0045494)2.87894398
124reproduction (GO:0000003)2.87501117
125negative regulation of astrocyte differentiation (GO:0048712)2.85818747
126negative regulation of systemic arterial blood pressure (GO:0003085)2.85790474
127artery development (GO:0060840)2.83593463
128regulation of receptor biosynthetic process (GO:0010869)2.83021700
129cardiac septum development (GO:0003279)2.81829087
130synapsis (GO:0007129)2.81543169
131lung morphogenesis (GO:0060425)2.81199046
132mitochondrion degradation (GO:0000422)2.80700521
133DNA integration (GO:0015074)2.78819576
134apoptotic process involved in development (GO:1902742)2.77199636
135regulation of glomerulus development (GO:0090192)2.76349408
136plasma membrane fusion (GO:0045026)2.75523318
137sulfate transport (GO:0008272)2.74940328
138regulation of timing of cell differentiation (GO:0048505)2.74712366
139left/right axis specification (GO:0070986)2.73908617
140ventricular system development (GO:0021591)2.73031087
141protein K11-linked deubiquitination (GO:0035871)2.72970780
142detection of molecule of bacterial origin (GO:0032490)2.69995322
143keratinocyte development (GO:0003334)2.68039805
144cellular response to gamma radiation (GO:0071480)2.67992076
145regulation of glucokinase activity (GO:0033131)2.67802621
146regulation of hexokinase activity (GO:1903299)2.67802621
147cell-cell recognition (GO:0009988)2.65340270
148female gonad development (GO:0008585)2.61238725
149regulation of activation of Janus kinase activity (GO:0010533)2.60053927
150kinetochore organization (GO:0051383)2.57254343
151regulation of nuclear cell cycle DNA replication (GO:0033262)2.51789433
152nonmotile primary cilium assembly (GO:0035058)2.50780627
153chromosome organization involved in meiosis (GO:0070192)2.48618014
154GTP biosynthetic process (GO:0006183)2.48330705
155GPI anchor biosynthetic process (GO:0006506)2.48060562
156histone H2B ubiquitination (GO:0033523)2.47808915
157cellular component assembly involved in morphogenesis (GO:0010927)2.46977515
158synaptonemal complex organization (GO:0070193)2.45691585
159ceramide catabolic process (GO:0046514)2.42530031
160preassembly of GPI anchor in ER membrane (GO:0016254)2.42246155
161righting reflex (GO:0060013)2.41571222
162cilium morphogenesis (GO:0060271)2.40995522
163cytochrome complex assembly (GO:0017004)2.40332350
164fertilization (GO:0009566)2.39864230
165cerebral cortex radially oriented cell migration (GO:0021799)2.39527016
166negative regulation of homotypic cell-cell adhesion (GO:0034111)2.38802913
167meiotic cell cycle (GO:0051321)2.36021627
168aminoglycoside antibiotic metabolic process (GO:0030647)2.34838729
169replicative senescence (GO:0090399)2.33903619
170protein heterotetramerization (GO:0051290)2.33899046
171adenosine metabolic process (GO:0046085)2.33633205
172binding of sperm to zona pellucida (GO:0007339)2.33578723
173superoxide metabolic process (GO:0006801)2.32713071
174long-chain fatty acid biosynthetic process (GO:0042759)2.32475653
175regulation of development, heterochronic (GO:0040034)2.32468569
176protein K6-linked ubiquitination (GO:0085020)2.32456572
177meiosis I (GO:0007127)2.32029111
178inner ear receptor stereocilium organization (GO:0060122)2.31686708
179response to pheromone (GO:0019236)2.31610989
180presynaptic membrane assembly (GO:0097105)2.31476233
181DNA double-strand break processing (GO:0000729)2.30375880
182meiotic nuclear division (GO:0007126)2.29265113
183synaptonemal complex assembly (GO:0007130)2.28929563
184appendage development (GO:0048736)2.28129080
185limb development (GO:0060173)2.28129080
186auditory receptor cell stereocilium organization (GO:0060088)2.27844318
187positive regulation of CREB transcription factor activity (GO:0032793)2.26841461
188regulation of rhodopsin mediated signaling pathway (GO:0022400)2.26466516
189polyol transport (GO:0015791)2.26185066
190negative regulation of myoblast differentiation (GO:0045662)2.24865846
191limb bud formation (GO:0060174)2.24494821
192branching involved in labyrinthine layer morphogenesis (GO:0060670)13.4284579

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human8.33211138
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.92687953
3EZH2_22144423_ChIP-Seq_EOC_Human3.28153450
4PCGF2_27294783_Chip-Seq_ESCs_Mouse3.08707690
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.03509948
6GBX2_23144817_ChIP-Seq_PC3_Human3.01323292
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.92411358
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.85140949
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.81828931
10SUZ12_27294783_Chip-Seq_NPCs_Mouse2.56216422
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.49015232
12TDRD3_21172665_ChIP-Seq_MCF-7_Human2.46654064
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46065424
14NFE2_27457419_Chip-Seq_LIVER_Mouse2.42045376
15PCGF2_27294783_Chip-Seq_NPCs_Mouse2.32266124
16VDR_22108803_ChIP-Seq_LS180_Human2.31648818
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.26909278
18ZNF274_21170338_ChIP-Seq_K562_Hela2.13623888
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.10919279
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09251518
21CBX2_27304074_Chip-Seq_ESCs_Mouse2.07993570
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04017444
23EZH2_27294783_Chip-Seq_NPCs_Mouse2.02553415
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98900686
25EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.96731001
26AHR_22903824_ChIP-Seq_MCF-7_Human1.95628805
27TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.95087868
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94624742
29NANOG_18555785_Chip-Seq_ESCs_Mouse1.92869111
30P53_22387025_ChIP-Seq_ESCs_Mouse1.89692288
31STAT3_18555785_Chip-Seq_ESCs_Mouse1.89265171
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.89175697
33SUZ12_18555785_Chip-Seq_ESCs_Mouse1.88658041
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87363915
35MYC_18940864_ChIP-ChIP_HL60_Human1.87303960
36EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.85078993
37E2F1_18555785_Chip-Seq_ESCs_Mouse1.82498300
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81622564
39IGF1R_20145208_ChIP-Seq_DFB_Human1.80337736
40NMYC_18555785_Chip-Seq_ESCs_Mouse1.77638526
41ARNT_22903824_ChIP-Seq_MCF-7_Human1.76818080
42P300_18555785_Chip-Seq_ESCs_Mouse1.75020848
43RUNX1_27457419_Chip-Seq_LIVER_Mouse1.74491420
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.72993863
45OCT4_18555785_Chip-Seq_ESCs_Mouse1.70199462
46CMYC_18555785_Chip-Seq_ESCs_Mouse1.69783929
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68978812
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68978812
49RNF2_27304074_Chip-Seq_NSC_Mouse1.68399784
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63566970
51TAF15_26573619_Chip-Seq_HEK293_Human1.63214828
52ZFX_18555785_Chip-Seq_ESCs_Mouse1.63073931
53P300_19829295_ChIP-Seq_ESCs_Human1.62584557
54SOX2_18555785_Chip-Seq_ESCs_Mouse1.62584308
55KLF4_18555785_Chip-Seq_ESCs_Mouse1.60593041
56AUTS2_25519132_ChIP-Seq_293T-REX_Human1.60233132
57FUS_26573619_Chip-Seq_HEK293_Human1.58918278
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.58293970
59ESRRB_18555785_Chip-Seq_ESCs_Mouse1.58053143
60ER_23166858_ChIP-Seq_MCF-7_Human1.56595311
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56131084
62PU1_27457419_Chip-Seq_LIVER_Mouse1.55473188
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54306540
64TAL1_26923725_Chip-Seq_HPCs_Mouse1.53365429
65SMAD1_18555785_Chip-Seq_ESCs_Mouse1.51494002
66CTCF_18555785_Chip-Seq_ESCs_Mouse1.49807473
67CRX_20693478_ChIP-Seq_RETINA_Mouse1.45565581
68OCT4_21477851_ChIP-Seq_ESCs_Mouse1.41324188
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.38980095
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.38970861
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.38678243
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.38129267
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37978491
74IRF1_19129219_ChIP-ChIP_H3396_Human1.35415103
75SMAD4_21799915_ChIP-Seq_A2780_Human1.34078024
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33635153
77JARID2_20064375_ChIP-Seq_MESCs_Mouse1.33368449
78KAP1_22055183_ChIP-Seq_ESCs_Mouse1.32007789
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.31130749
80EZH2_27304074_Chip-Seq_ESCs_Mouse1.30200462
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28509921
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27750784
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27345861
84EWS_26573619_Chip-Seq_HEK293_Human1.27187945
85SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.27051592
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26448508
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26448508
88SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.26196569
89LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24290725
90TP53_20018659_ChIP-ChIP_R1E_Mouse1.22675332
91GATA3_21878914_ChIP-Seq_MCF-7_Human1.22356192
92KDM2B_26808549_Chip-Seq_REH_Human1.21736812
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20959878
94DROSHA_22980978_ChIP-Seq_HELA_Human1.20380878
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18843122
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18669565
97IRF8_21731497_ChIP-ChIP_J774_Mouse1.18099540
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18031014
99SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.17731063
100ESR1_21235772_ChIP-Seq_MCF-7_Human1.17072548
101TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16487140
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.16159298
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.15588121
104SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15544423
105* TCF4_23295773_ChIP-Seq_U87_Human1.15383176
106PRDM14_20953172_ChIP-Seq_ESCs_Human1.15125499
107RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14930001
108SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14384342
109REST_21632747_ChIP-Seq_MESCs_Mouse1.12481943
110TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12042794
111CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11804794
112CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11687457
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11616937
114SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10940477
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10157366
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08762134
117KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08671749
118IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07716609
119NCOR_22424771_ChIP-Seq_293T_Human1.06618662
120POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05999030
121STAT3_23295773_ChIP-Seq_U87_Human1.05356956
122GATA1_26923725_Chip-Seq_HPCs_Mouse1.04681175
123TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03285854
124STAT1_17558387_ChIP-Seq_HELA_Human1.02736717
125RUNX2_22187159_ChIP-Seq_PCA_Human1.02352177
126MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00946858
127RNF2_27304074_Chip-Seq_ESCs_Mouse1.00747530
128EZH2_27294783_Chip-Seq_ESCs_Mouse0.99184996
129FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.98359721
130BCAT_22108803_ChIP-Seq_LS180_Human0.98046103
131IRF8_22096565_ChIP-ChIP_GC-B_Human0.97776581
132P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96760465
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95361293
134NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94383069
135* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94140575
136AR_25329375_ChIP-Seq_VCAP_Human0.93583674
137JUN_21703547_ChIP-Seq_K562_Human0.93475629
138VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92675012
139RXR_22108803_ChIP-Seq_LS180_Human0.92332010
140NANOG_20526341_ChIP-Seq_ESCs_Human0.92286308
141KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91062674
142STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.89026157
143FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88740521
144FOXA1_25329375_ChIP-Seq_VCAP_Human0.88740521
145BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86097409
146YY1_22570637_ChIP-Seq_MALME-3M_Human0.85503329
147TP53_18474530_ChIP-ChIP_U2OS_Human0.85369068
148SMAD4_21741376_ChIP-Seq_EPCs_Human0.84733761
149RING1B_27294783_Chip-Seq_ESCs_Mouse0.84410465
150TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.84292351
151* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.79733068
152ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79251043
153FOXM1_26456572_ChIP-Seq_MCF-7_Human0.78281731
154TAF2_19829295_ChIP-Seq_ESCs_Human0.77899394
155SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.77328483
156CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76964989
157CDX2_20551321_ChIP-Seq_CACO-2_Human0.75698815
158FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74884303

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology6.10344046
2MP0005670_abnormal_white_adipose6.01692954
3MP0000013_abnormal_adipose_tissue4.12553048
4MP0005367_renal/urinary_system_phenotyp4.10226546
5MP0000516_abnormal_urinary_system4.10226546
6MP0003315_abnormal_perineum_morphology4.00555343
7MP0006292_abnormal_olfactory_placode3.43769046
8MP0005410_abnormal_fertilization3.31279553
9MP0009053_abnormal_anal_canal3.30204463
10MP0003136_yellow_coat_color3.26674849
11MP0001188_hyperpigmentation3.20559967
12MP0001849_ear_inflammation3.06368893
13MP0003693_abnormal_embryo_hatching2.87844595
14MP0004185_abnormal_adipocyte_glucose2.86938184
15MP0000566_synostosis2.72368919
16MP0002102_abnormal_ear_morphology2.68415205
17MP0008057_abnormal_DNA_replication2.48137736
18MP0001661_extended_life_span2.47659466
19MP0005171_absent_coat_pigmentation2.46466614
20MP0003119_abnormal_digestive_system2.43077499
21MP0008877_abnormal_DNA_methylation2.42192168
22MP0001986_abnormal_taste_sensitivity2.39879389
23MP0003283_abnormal_digestive_organ2.39237917
24MP0008058_abnormal_DNA_repair2.28859513
25MP0004130_abnormal_muscle_cell2.26338340
26MP0002277_abnormal_respiratory_mucosa2.22287186
27MP0000015_abnormal_ear_pigmentation2.16601251
28MP0005645_abnormal_hypothalamus_physiol2.02011825
29MP0009765_abnormal_xenobiotic_induced1.94229702
30MP0003656_abnormal_erythrocyte_physiolo1.93784844
31MP0003698_abnormal_male_reproductive1.88908249
32MP0005646_abnormal_pituitary_gland1.88321763
33MP0002282_abnormal_trachea_morphology1.86893809
34MP0003941_abnormal_skin_development1.82531612
35MP0002138_abnormal_hepatobiliary_system1.82496431
36MP0004381_abnormal_hair_follicle1.81334269
37MP0003787_abnormal_imprinting1.77912372
38MP0003937_abnormal_limbs/digits/tail_de1.77748863
39MP0005174_abnormal_tail_pigmentation1.75122124
40MP0005409_darkened_coat_color1.71107404
41MP0009697_abnormal_copulation1.70914643
42MP0000537_abnormal_urethra_morphology1.67369192
43MP0002638_abnormal_pupillary_reflex1.65899988
44MP0002132_abnormal_respiratory_system1.65669917
45MP0001929_abnormal_gametogenesis1.65412158
46MP0004742_abnormal_vestibular_system1.63738949
47MP0003878_abnormal_ear_physiology1.63397376
48MP0005377_hearing/vestibular/ear_phenot1.63397376
49MP0008995_early_reproductive_senescence1.62283084
50MP0002210_abnormal_sex_determination1.61250312
51MP0005551_abnormal_eye_electrophysiolog1.60662058
52MP0001984_abnormal_olfaction1.58907809
53MP0003950_abnormal_plasma_membrane1.54219708
54MP0003880_abnormal_central_pattern1.48023675
55MP0001486_abnormal_startle_reflex1.47900443
56MP0000003_abnormal_adipose_tissue1.46017403
57MP0002751_abnormal_autonomic_nervous1.44968111
58MP0002938_white_spotting1.42145513
59MP0000372_irregular_coat_pigmentation1.41855093
60MP0008872_abnormal_physiological_respon1.39873235
61MP0002148_abnormal_hypersensitivity_rea1.39466769
62MP0000026_abnormal_inner_ear1.36413845
63MP0009384_cardiac_valve_regurgitation1.33739476
64MP0002876_abnormal_thyroid_physiology1.31423370
65MP0000569_abnormal_digit_pigmentation1.30844544
66MP0003724_increased_susceptibility_to1.30659593
67MP0005076_abnormal_cell_differentiation1.27788130
68MP0001835_abnormal_antigen_presentation1.26547132
69MP0008260_abnormal_autophagy1.25221334
70MP0002160_abnormal_reproductive_system1.24735559
71MP0009046_muscle_twitch1.22489587
72MP0003938_abnormal_ear_development1.22209228
73MP0001485_abnormal_pinna_reflex1.22091020
74MP0001963_abnormal_hearing_physiology1.21388254
75MP0003936_abnormal_reproductive_system1.20482422
76MP0005379_endocrine/exocrine_gland_phen1.19935596
77MP0005253_abnormal_eye_physiology1.18606356
78MP0002735_abnormal_chemical_nociception1.15555350
79MP0003786_premature_aging1.13153128
80MP0001145_abnormal_male_reproductive1.09966259
81MP0002163_abnormal_gland_morphology1.09618505
82MP0002095_abnormal_skin_pigmentation1.09610498
83MP0005075_abnormal_melanosome_morpholog1.08517139
84MP0004885_abnormal_endolymph1.07997937
85MP0005671_abnormal_response_to1.07681443
86MP0009785_altered_susceptibility_to1.02981319
87MP0005423_abnormal_somatic_nervous1.02806739
88MP0008004_abnormal_stomach_pH1.02687928
89MP0000653_abnormal_sex_gland1.02469945
90MP0003890_abnormal_embryonic-extraembry1.01829865
91MP0003718_maternal_effect1.00547594
92MP0010094_abnormal_chromosome_stability0.96308294
93MP0008789_abnormal_olfactory_epithelium0.95831815
94MP0005503_abnormal_tendon_morphology0.93777600
95MP0004133_heterotaxia0.93654781
96MP0001346_abnormal_lacrimal_gland0.93505904
97MP0006276_abnormal_autonomic_nervous0.91865540
98MP0002249_abnormal_larynx_morphology0.90684278
99MP0000678_abnormal_parathyroid_gland0.90528310
100MP0000534_abnormal_ureter_morphology0.90191380
101MP0002736_abnormal_nociception_after0.88930036
102MP0010386_abnormal_urinary_bladder0.88596422
103MP0000383_abnormal_hair_follicle0.88027853
104MP0002419_abnormal_innate_immunity0.87775454
105MP0005195_abnormal_posterior_eye0.87232787
106MP0005451_abnormal_body_composition0.86586733
107MP0002161_abnormal_fertility/fecundity0.86490928
108MP0000049_abnormal_middle_ear0.85336537
109MP0005389_reproductive_system_phenotype0.84317666
110MP0001790_abnormal_immune_system0.84102084
111MP0005387_immune_system_phenotype0.84102084
112MP0008007_abnormal_cellular_replicative0.83816865
113MP0002752_abnormal_somatic_nervous0.83481647
114MP0001968_abnormal_touch/_nociception0.83120891
115MP0001119_abnormal_female_reproductive0.82828562
116MP0003172_abnormal_lysosome_physiology0.82064128
117MP0004782_abnormal_surfactant_physiolog0.82051312
118MP0001502_abnormal_circadian_rhythm0.81295094
119MP0000631_abnormal_neuroendocrine_gland0.79375184
120MP0006072_abnormal_retinal_apoptosis0.78303163
121MP0003942_abnormal_urinary_system0.77639879
122MP0001905_abnormal_dopamine_level0.76160689
123MP0009250_abnormal_appendicular_skeleto0.75556996
124MP0003111_abnormal_nucleus_morphology0.74766249
125MP0004142_abnormal_muscle_tone0.74668025
126MP0002557_abnormal_social/conspecific_i0.74065782
127MP0005025_abnormal_response_to0.73708196
128MP0001324_abnormal_eye_pigmentation0.72740512
129MP0000613_abnormal_salivary_gland0.71879960
130MP0002572_abnormal_emotion/affect_behav0.71712637
131MP0003646_muscle_fatigue0.71242493
132MP0002116_abnormal_craniofacial_bone0.70870879
133MP0005394_taste/olfaction_phenotype0.70473010
134MP0005499_abnormal_olfactory_system0.70473010
135MP0003879_abnormal_hair_cell0.70455754
136MP0005647_abnormal_sex_gland0.70283021
137MP0001270_distended_abdomen0.70037640
138MP0008873_increased_physiological_sensi0.68303607
139MP0001765_abnormal_ion_homeostasis0.68214324
140MP0000467_abnormal_esophagus_morphology0.66814457
141MP0002837_dystrophic_cardiac_calcinosis0.65208149
142MP0001440_abnormal_grooming_behavior0.64544367
143MP0008770_decreased_survivor_rate0.64442712
144MP0009379_abnormal_foot_pigmentation0.64423285
145MP0000778_abnormal_nervous_system0.62297243
146MP0001697_abnormal_embryo_size0.60810966
147MP0002111_abnormal_tail_morphology0.60599378
148MP0000470_abnormal_stomach_morphology0.59600341
149MP0010678_abnormal_skin_adnexa0.59405159
150MP0002135_abnormal_kidney_morphology0.57952589
151MP0002272_abnormal_nervous_system0.55050924
152MP0003635_abnormal_synaptic_transmissio0.53448838
153MP0006036_abnormal_mitochondrial_physio0.53102255
154MP0002971_abnormal_brown_adipose0.51101367
155MP0005666_abnormal_adipose_tissue0.49958251
156MP0009745_abnormal_behavioral_response0.49767705
157MP0000230_abnormal_systemic_arterial0.49129509
158MP0009780_abnormal_chondrocyte_physiolo0.47722084
159MP0001944_abnormal_pancreas_morphology0.44361838
160MP0002928_abnormal_bile_duct0.42902947
161MP0001756_abnormal_urination0.42467006
162MP0002152_abnormal_brain_morphology0.41760058

Predicted human phenotypes

RankGene SetZ-score
1Short 1st metacarpal (HP:0010034)8.05278699
2Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)8.05278699
3Abnormality of the 1st metacarpal (HP:0010009)7.09396525
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.98809511
5Stenosis of the external auditory canal (HP:0000402)6.80626314
6Dynein arm defect of respiratory motile cilia (HP:0012255)6.09527860
7Absent/shortened dynein arms (HP:0200106)6.09527860
8Carpal bone hypoplasia (HP:0001498)5.52811587
9Short phalanx of the thumb (HP:0009660)5.26777958
10Abnormal respiratory motile cilium physiology (HP:0012261)5.22511002
11Chromosomal breakage induced by crosslinking agents (HP:0003221)5.10758867
12Abnormal ciliary motility (HP:0012262)5.04174950
13Fused cervical vertebrae (HP:0002949)4.84172301
14Abnormal respiratory motile cilium morphology (HP:0005938)4.81684856
15Abnormal respiratory epithelium morphology (HP:0012253)4.81684856
16Absent thumb (HP:0009777)4.52173378
17Short hallux (HP:0010109)4.47828958
18Chromsome breakage (HP:0040012)4.45626246
19Rectovaginal fistula (HP:0000143)4.31693026
20Rectal fistula (HP:0100590)4.31693026
21Osteomalacia (HP:0002749)4.29967935
22Aplasia/Hypoplasia of the hallux (HP:0008362)4.15531709
23Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)4.04251132
24Rhinitis (HP:0012384)3.93251403
25Intestinal fistula (HP:0100819)3.88793122
26Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.88594458
27Vaginal fistula (HP:0004320)3.70307712
28Aplasia/Hypoplasia involving the musculature (HP:0001460)3.69553631
29Oligomenorrhea (HP:0000876)3.48885614
30Synostosis of carpal bones (HP:0005048)3.39696275
31Acanthocytosis (HP:0001927)3.32873759
32Tubulointerstitial nephritis (HP:0001970)3.26884427
33Absent radius (HP:0003974)3.24708138
34Abnormality of the parathyroid morphology (HP:0011766)3.24267106
35Short humerus (HP:0005792)3.23658832
36Horseshoe kidney (HP:0000085)3.21376372
37Reticulocytopenia (HP:0001896)3.19478845
38Nephronophthisis (HP:0000090)3.13610459
39Absent forearm bone (HP:0003953)3.10566780
40Aplasia involving forearm bones (HP:0009822)3.10566780
41Duplicated collecting system (HP:0000081)3.05191880
42Aplasia/hypoplasia of the humerus (HP:0006507)3.01646349
43Pancreatic fibrosis (HP:0100732)2.96637496
44True hermaphroditism (HP:0010459)2.92480790
45Short thumb (HP:0009778)2.92205845
46Abnormality of the renal collecting system (HP:0004742)2.90681933
47Medial flaring of the eyebrow (HP:0010747)2.87988362
48Decreased subcutaneous fat (HP:0001002)2.87137935
49Hypoalphalipoproteinemia (HP:0003233)2.85494400
50Pendular nystagmus (HP:0012043)2.83822739
51Optic nerve coloboma (HP:0000588)2.83631868
52Prostate neoplasm (HP:0100787)2.78251492
53Abnormality of the nasal septum (HP:0000419)2.74336872
54Abnormality of the renal medulla (HP:0100957)2.73071550
55Maternal diabetes (HP:0009800)2.71518642
56Toxemia of pregnancy (HP:0100603)2.69218883
57Abnormality of the proximal phalanges of the hand (HP:0009834)2.66529805
58Chronic bronchitis (HP:0004469)2.60898016
59Reduced subcutaneous adipose tissue (HP:0003758)2.60794980
60Febrile seizures (HP:0002373)2.60027322
61Septo-optic dysplasia (HP:0100842)2.59694331
62Meckel diverticulum (HP:0002245)2.55604814
63Abnormality of the carotid arteries (HP:0005344)2.53267907
64Paralysis (HP:0003470)2.52170964
65White forelock (HP:0002211)2.50612990
66Decreased central vision (HP:0007663)2.49351004
67Anal stenosis (HP:0002025)2.49105301
68Bronchiectasis (HP:0002110)2.47214522
69Median cleft lip (HP:0000161)2.44726982
70Abnormality of the ileum (HP:0001549)2.41322454
71Abnormality of the preputium (HP:0100587)2.40937328
72Postaxial foot polydactyly (HP:0001830)2.40102318
73Congenital stationary night blindness (HP:0007642)2.38259344
74Absent rod-and cone-mediated responses on ERG (HP:0007688)2.37762085
75Aplasia/Hypoplasia of the uvula (HP:0010293)2.36634468
76Pancreatic cysts (HP:0001737)2.36162847
77Patchy hypopigmentation of hair (HP:0011365)2.33840316
78Abnormality of midbrain morphology (HP:0002418)2.32763398
79Molar tooth sign on MRI (HP:0002419)2.32763398
80Tachypnea (HP:0002789)2.31377402
81Insulin-resistant diabetes mellitus (HP:0000831)2.30908043
82Nephrogenic diabetes insipidus (HP:0009806)2.30812117
83Congenital primary aphakia (HP:0007707)2.30713201
84Carpal synostosis (HP:0009702)2.28650106
85Vertebral fusion (HP:0002948)2.27541929
86Vitreoretinal degeneration (HP:0000655)2.27296947
87Clubbing of toes (HP:0100760)2.25626752
88Gait imbalance (HP:0002141)2.25453630
89Abnormality of pyrimidine metabolism (HP:0004353)2.25249084
90Chorioretinal atrophy (HP:0000533)2.24104294
91Preaxial hand polydactyly (HP:0001177)2.23887862
92Recurrent sinusitis (HP:0011108)2.21740219
93Morphological abnormality of the middle ear (HP:0008609)2.21418745
94Abnormality of incisor morphology (HP:0011063)2.21105589
95Optic nerve hypoplasia (HP:0000609)2.19960810
96Hypoplasia of the ulna (HP:0003022)2.19814095
97Abnormality of subcutaneous fat tissue (HP:0001001)2.19468879
98Optic neuritis (HP:0100653)2.18399552
99Retrobulbar optic neuritis (HP:0100654)2.18399552
100Choanal stenosis (HP:0000452)2.17390878
101Congenital hepatic fibrosis (HP:0002612)2.17224270
102Hyperuricemia (HP:0002149)2.15153214
103Increased purine levels (HP:0004368)2.15153214
104Ectopic kidney (HP:0000086)2.14570266
105Triphalangeal thumb (HP:0001199)2.11983779
106Parakeratosis (HP:0001036)2.11831863
107Abnormality of the middle phalanges of the toes (HP:0010183)2.08641961
108Aplasia cutis congenita (HP:0001057)2.06537061
109Dyschromatopsia (HP:0007641)2.06113892
110Aplasia/Hypoplasia of the tibia (HP:0005772)2.05201619
111Preaxial foot polydactyly (HP:0001841)2.03448461
112Aplasia/Hypoplasia of the lens (HP:0008063)2.03392042
113Attenuation of retinal blood vessels (HP:0007843)2.02496854
114Neoplasm of the oral cavity (HP:0100649)2.00631337
115Renal agenesis (HP:0000104)1.99779267
116Abnormality of DNA repair (HP:0003254)1.99535428
117Genetic anticipation (HP:0003743)1.99322749
118Male pseudohermaphroditism (HP:0000037)1.98555731
119Severe muscular hypotonia (HP:0006829)1.98350663
120Acute necrotizing encephalopathy (HP:0006965)1.98042240
121Status epilepticus (HP:0002133)1.97926606
122Hypoplasia of the radius (HP:0002984)1.97881801
123Chronic hepatic failure (HP:0100626)1.97224548
124Nephroblastoma (Wilms tumor) (HP:0002667)1.96078858
125Esotropia (HP:0000565)1.95820587
126Abnormality of chromosome stability (HP:0003220)1.94742540
127Ureteral duplication (HP:0000073)1.93824313
128Duplication of thumb phalanx (HP:0009942)1.90975731
129Synostosis involving bones of the hand (HP:0004278)1.90804767
130Tented upper lip vermilion (HP:0010804)1.90721756
131Congenital sensorineural hearing impairment (HP:0008527)1.90574196
132Abolished electroretinogram (ERG) (HP:0000550)1.88607989
133Supernumerary spleens (HP:0009799)1.87745436
134Abnormal biliary tract physiology (HP:0012439)1.86787914
135Bile duct proliferation (HP:0001408)1.86787914
136Embryonal renal neoplasm (HP:0011794)1.86493678
137Absent septum pellucidum (HP:0001331)1.85082368
138Conical tooth (HP:0000698)1.84552892
139Abnormality of reticulocytes (HP:0004312)1.84519940
140Abnormal rod and cone electroretinograms (HP:0008323)1.83374360
141Abnormality of molar (HP:0011077)1.82678154
142Abnormality of molar morphology (HP:0011070)1.82678154
143Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79888143
144Genital tract atresia (HP:0001827)1.79792233
145Poor coordination (HP:0002370)1.79581550
146Facial cleft (HP:0002006)1.79152760
147Obstructive lung disease (HP:0006536)1.78722884
148Chronic obstructive pulmonary disease (HP:0006510)1.78722884
149Abnormality of the septum pellucidum (HP:0007375)1.78498907
150Abnormal mitochondria in muscle tissue (HP:0008316)1.77596503
151Fetal akinesia sequence (HP:0001989)1.77534480
152Aplasia/Hypoplasia of the tongue (HP:0010295)1.76959803
153Humeroradial synostosis (HP:0003041)1.75834375
154Synostosis involving the elbow (HP:0003938)1.75834375
155Aganglionic megacolon (HP:0002251)1.75379179
156Astigmatism (HP:0000483)1.75024246
157Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.74882330
158Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.74727021
159Renal cortical cysts (HP:0000803)1.74154266
160Azoospermia (HP:0000027)1.74137141
161Short tibia (HP:0005736)1.74117512
162Abnormality of the renal cortex (HP:0011035)1.73159952
163Type 2 muscle fiber atrophy (HP:0003554)1.71614689
164Aplasia/Hypoplasia of the ulna (HP:0006495)1.71473297
165Microvesicular hepatic steatosis (HP:0001414)1.71327648
166Symphalangism affecting the phalanges of the hand (HP:0009773)1.71062361
167Absent toe (HP:0010760)1.70907006
168Abnormality of the dental pulp (HP:0006479)1.68250545
169Vaginal atresia (HP:0000148)1.68102241
170Bone marrow hypocellularity (HP:0005528)1.67509353
171Oligohydramnios (HP:0001562)1.66659752
172Abnormality of permanent molar morphology (HP:0011071)1.66546724
173Abnormality of the dental root (HP:0006486)1.66546724
174Taurodontia (HP:0000679)1.66546724
175Bony spicule pigmentary retinopathy (HP:0007737)1.65924459
176Abnormal hair whorl (HP:0010721)1.65358834
177Upper limb muscle weakness (HP:0003484)1.64654879
178Recurrent pneumonia (HP:0006532)1.63715935
179Postaxial hand polydactyly (HP:0001162)1.63585063

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.54623281
2CDK94.41399726
3FRK4.00442720
4CASK3.78146816
5STK163.31009745
6ZAK3.14839499
7IRAK33.02396999
8TXK2.85266930
9MAP2K12.77460452
10TNIK2.46925095
11IRAK42.37041179
12MAP2K72.29982734
13GRK11.98874716
14EIF2AK21.95981479
15MKNK21.86040968
16PLK41.85330074
17PRPF4B1.83159455
18ACVR1B1.79432241
19SIK31.79087626
20MUSK1.74387053
21IRAK21.72569073
22MAP3K141.72241776
23BMPR21.71742244
24PINK11.69542014
25SRPK11.68087858
26IRAK11.63050433
27ADRBK21.61717359
28NEK61.61074019
29INSRR1.55723002
30PNCK1.52893784
31NUAK11.51661545
32VRK11.45126610
33BMPR1B1.43167387
34AURKA1.41624159
35GRK71.38955873
36YES11.35867882
37PKN11.35191150
38BLK1.32697263
39SYK1.31637406
40STK38L1.30672603
41MAPK151.28262095
42BUB11.27901622
43CDK31.25091710
44PBK1.23169016
45PHKG11.22916527
46PHKG21.22916527
47MAPK131.10495924
48AKT31.06841021
49TNK21.05394540
50TEC1.04532142
51RIPK41.03931628
52MKNK11.03715732
53CSNK1A11.02260456
54CLK11.00888034
55MAP3K40.97538868
56MAPK110.96546675
57CSNK1G20.93684041
58CSNK1A1L0.93277421
59CSNK1D0.91183509
60CSNK1G30.89396629
61IKBKB0.86428497
62STK390.85774066
63NME10.84138156
64ERBB30.82395567
65NLK0.80344693
66NEK90.79823905
67CSNK1G10.78473877
68SGK2230.78259820
69SGK4940.78259820
70PIK3CA0.77993038
71PAK60.77798303
72CSK0.76784955
73MAP4K20.76651939
74SIK20.75296261
75CCNB10.74876436
76TAF10.73101534
77PDK20.72609652
78FLT30.72345711
79PLK20.71870859
80CDK80.70852250
81ADRBK10.69215375
82MAP2K60.68158131
83RPS6KA60.68109183
84WNK30.67692276
85PDK30.64663343
86PDK40.64663343
87PRKD20.63629051
88TTK0.62950750
89PRKCI0.62151667
90ATR0.62140310
91IKBKE0.61665733
92BRD40.61628867
93STK240.61516121
94PRKCE0.60853188
95NEK20.59748567
96TAOK20.59721962
97BRSK20.56591858
98GRK50.56260806
99TGFBR10.55939939
100MAP2K40.54468619
101CHEK20.54316462
102LATS10.54115590
103NTRK30.53976185
104STK110.53068702
105CAMKK10.52067226
106PLK10.51954104
107MAPK80.51709470
108MARK10.50605214
109DYRK1A0.50315291
110HIPK20.49514181
111CAMK10.49409877
112PIM20.49105235
113STK30.48684898
114MARK30.48442024
115SGK10.48154388
116OXSR10.47959977
117CDK50.47901933
118SGK20.47280097
119SGK30.47132938
120MAPKAPK30.47127822
121PRKDC0.46369265
122PRKAA20.45995601
123PRKACA0.45500260
124MAPK70.45110454
125LYN0.44700799
126DYRK20.44451251
127MAPK90.41583485
128PRKAA10.41579108
129LCK0.41539215
130MAPK30.41346676
131MAP3K120.41321955
132GSK3B0.41126498
133BCR0.41114143
134EIF2AK30.40406979
135PLK30.39516223
136MAP2K20.39216704
137MAPK140.37885672
138PRKG10.37851333
139DAPK20.37470508
140CAMK2A0.37292467
141RPS6KA20.36811232
142RPS6KB10.36771504
143TIE10.35183343
144RPS6KA50.33263321
145ATM0.33038871
146CHUK0.32998374
147TAOK30.32446348
148WNK40.31718167
149CDC70.30971875
150PRKCG0.30653148
151PIK3CG0.30113398
152BTK0.28775677
153CSNK2A10.28049839
154DYRK30.26979780
155PTK2B0.26699629
156OBSCN0.26688197
157EPHA40.25767872
158PRKCQ0.25250747
159MAPKAPK50.24778542
160CDK70.24114667

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.25043217
2Renin-angiotensin system_Homo sapiens_hsa046143.86146581
3Fanconi anemia pathway_Homo sapiens_hsa034603.22172983
4Phototransduction_Homo sapiens_hsa047442.77114357
5Sulfur metabolism_Homo sapiens_hsa009202.70548259
6Homologous recombination_Homo sapiens_hsa034402.42505748
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.32355382
8Basal transcription factors_Homo sapiens_hsa030222.19309613
9Graft-versus-host disease_Homo sapiens_hsa053322.17560578
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09981318
11Selenocompound metabolism_Homo sapiens_hsa004502.07455718
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.97753625
13Basal cell carcinoma_Homo sapiens_hsa052171.93910837
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.87073442
15Chemical carcinogenesis_Homo sapiens_hsa052041.85118248
16Allograft rejection_Homo sapiens_hsa053301.80087850
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79005558
18Arachidonic acid metabolism_Homo sapiens_hsa005901.77947715
19Sphingolipid metabolism_Homo sapiens_hsa006001.72579182
20RNA polymerase_Homo sapiens_hsa030201.72145892
21Linoleic acid metabolism_Homo sapiens_hsa005911.69984308
22Nicotine addiction_Homo sapiens_hsa050331.67417476
23Autoimmune thyroid disease_Homo sapiens_hsa053201.65091558
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.64117074
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.60125219
26Ether lipid metabolism_Homo sapiens_hsa005651.59612658
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.56818210
28Systemic lupus erythematosus_Homo sapiens_hsa053221.56187792
29Rheumatoid arthritis_Homo sapiens_hsa053231.48283563
30Glycerolipid metabolism_Homo sapiens_hsa005611.47161767
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46494410
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.45317923
33Asthma_Homo sapiens_hsa053101.42496139
34Nitrogen metabolism_Homo sapiens_hsa009101.42193493
35Taste transduction_Homo sapiens_hsa047421.41457668
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40122051
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.38663459
38Non-homologous end-joining_Homo sapiens_hsa034501.36242823
39Vitamin digestion and absorption_Homo sapiens_hsa049771.35111139
40Thyroid cancer_Homo sapiens_hsa052161.34568527
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32005230
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.30397766
43Pyrimidine metabolism_Homo sapiens_hsa002401.26029645
44Purine metabolism_Homo sapiens_hsa002301.24738096
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23955498
46Sulfur relay system_Homo sapiens_hsa041221.18835934
47Hematopoietic cell lineage_Homo sapiens_hsa046401.17059492
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16275242
49Measles_Homo sapiens_hsa051621.14165852
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08193405
51Other glycan degradation_Homo sapiens_hsa005111.06202671
52Nucleotide excision repair_Homo sapiens_hsa034201.03898333
53Primary immunodeficiency_Homo sapiens_hsa053401.03419759
54Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01960763
55Huntingtons disease_Homo sapiens_hsa050161.00174948
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99018496
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98738895
58Serotonergic synapse_Homo sapiens_hsa047260.97799304
59Morphine addiction_Homo sapiens_hsa050320.95443234
60Vitamin B6 metabolism_Homo sapiens_hsa007500.94694202
61Base excision repair_Homo sapiens_hsa034100.90820581
62Olfactory transduction_Homo sapiens_hsa047400.90702768
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90329814
64African trypanosomiasis_Homo sapiens_hsa051430.88931252
65Caffeine metabolism_Homo sapiens_hsa002320.88593208
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88088739
67Type I diabetes mellitus_Homo sapiens_hsa049400.86919636
68Alcoholism_Homo sapiens_hsa050340.84595678
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84412815
70Tryptophan metabolism_Homo sapiens_hsa003800.82457012
71Malaria_Homo sapiens_hsa051440.82175328
72Collecting duct acid secretion_Homo sapiens_hsa049660.81687463
73Fat digestion and absorption_Homo sapiens_hsa049750.81544231
74Oxidative phosphorylation_Homo sapiens_hsa001900.80940434
75Herpes simplex infection_Homo sapiens_hsa051680.80082833
76DNA replication_Homo sapiens_hsa030300.77768408
77RNA degradation_Homo sapiens_hsa030180.77739912
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77715978
79One carbon pool by folate_Homo sapiens_hsa006700.77583085
80Calcium signaling pathway_Homo sapiens_hsa040200.76757908
81Mismatch repair_Homo sapiens_hsa034300.75904265
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75579972
83Leishmaniasis_Homo sapiens_hsa051400.75393063
84Proteasome_Homo sapiens_hsa030500.72016570
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71798114
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70341090
87Protein export_Homo sapiens_hsa030600.69985192
88PPAR signaling pathway_Homo sapiens_hsa033200.68739822
89Hippo signaling pathway_Homo sapiens_hsa043900.67472183
90Phagosome_Homo sapiens_hsa041450.66241452
91ABC transporters_Homo sapiens_hsa020100.65420334
92Influenza A_Homo sapiens_hsa051640.64634367
93Glutamatergic synapse_Homo sapiens_hsa047240.63781368
94Butanoate metabolism_Homo sapiens_hsa006500.62111207
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61827642
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.60548314
97Melanoma_Homo sapiens_hsa052180.59155056
98Insulin secretion_Homo sapiens_hsa049110.58955236
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58516457
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58280835
101Ovarian steroidogenesis_Homo sapiens_hsa049130.57244724
102beta-Alanine metabolism_Homo sapiens_hsa004100.56018309
103GABAergic synapse_Homo sapiens_hsa047270.55208407
104Starch and sucrose metabolism_Homo sapiens_hsa005000.53233064
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53085129
106Tuberculosis_Homo sapiens_hsa051520.52999317
107TGF-beta signaling pathway_Homo sapiens_hsa043500.52911707
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.52833571
109TNF signaling pathway_Homo sapiens_hsa046680.52620365
110Regulation of autophagy_Homo sapiens_hsa041400.50524777
111Pertussis_Homo sapiens_hsa051330.48523350
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48513316
113p53 signaling pathway_Homo sapiens_hsa041150.47142341
114Spliceosome_Homo sapiens_hsa030400.46804963
115Salivary secretion_Homo sapiens_hsa049700.46727518
116Melanogenesis_Homo sapiens_hsa049160.46035185
117Cell cycle_Homo sapiens_hsa041100.45166209
118Gastric acid secretion_Homo sapiens_hsa049710.45106893
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.43029910
120Osteoclast differentiation_Homo sapiens_hsa043800.42779403
121Chemokine signaling pathway_Homo sapiens_hsa040620.42432542
122Cardiac muscle contraction_Homo sapiens_hsa042600.42400024
123mRNA surveillance pathway_Homo sapiens_hsa030150.41893438
124Pathways in cancer_Homo sapiens_hsa052000.41768785
125Renin secretion_Homo sapiens_hsa049240.40305429
126Cholinergic synapse_Homo sapiens_hsa047250.39814966
127Salmonella infection_Homo sapiens_hsa051320.39782189
128Wnt signaling pathway_Homo sapiens_hsa043100.38822778
129Mineral absorption_Homo sapiens_hsa049780.38718378
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.38237715
131Peroxisome_Homo sapiens_hsa041460.37802624
132Dorso-ventral axis formation_Homo sapiens_hsa043200.37615748
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37338874
134cAMP signaling pathway_Homo sapiens_hsa040240.37225452
135Axon guidance_Homo sapiens_hsa043600.36429219
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35885297
137Circadian entrainment_Homo sapiens_hsa047130.35553155
138Type II diabetes mellitus_Homo sapiens_hsa049300.34844755
139Legionellosis_Homo sapiens_hsa051340.34639205
140Epstein-Barr virus infection_Homo sapiens_hsa051690.34598310
141Hedgehog signaling pathway_Homo sapiens_hsa043400.34493275
142Steroid biosynthesis_Homo sapiens_hsa001000.33912250
143Ras signaling pathway_Homo sapiens_hsa040140.31891650
144Alzheimers disease_Homo sapiens_hsa050100.31839020
145Histidine metabolism_Homo sapiens_hsa003400.31328465
146Galactose metabolism_Homo sapiens_hsa000520.30735837
147Retinol metabolism_Homo sapiens_hsa008300.29654204
148Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28376622
149Cocaine addiction_Homo sapiens_hsa050300.27726033
150Oxytocin signaling pathway_Homo sapiens_hsa049210.26588927

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