WDR72

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with eight WD-40 repeats. Mutations in this gene have been associated with amelogenesis imperfecta hypomaturation type 2A3. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)9.68671039
2glyoxylate metabolic process (GO:0046487)5.61719283
3detection of molecule of bacterial origin (GO:0032490)5.17966290
4drug catabolic process (GO:0042737)5.01196637
5response to mercury ion (GO:0046689)4.85498327
6epoxygenase P450 pathway (GO:0019373)4.82770746
7exogenous drug catabolic process (GO:0042738)4.80103282
8L-phenylalanine catabolic process (GO:0006559)4.77354127
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.77354127
10omega-hydroxylase P450 pathway (GO:0097267)4.76659886
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.55543652
12L-phenylalanine metabolic process (GO:0006558)4.55543652
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.43586346
14energy homeostasis (GO:0097009)4.41835570
15cellular anion homeostasis (GO:0030002)4.33072900
16cellular glucuronidation (GO:0052695)4.31316903
17glycoside metabolic process (GO:0016137)4.29738455
18aromatic amino acid family catabolic process (GO:0009074)4.28961129
19glucuronate metabolic process (GO:0019585)4.25858820
20uronic acid metabolic process (GO:0006063)4.25858820
21L-methionine biosynthetic process (GO:0071265)4.19354915
22amino acid salvage (GO:0043102)4.19354915
23L-methionine salvage (GO:0071267)4.19354915
24serine family amino acid catabolic process (GO:0009071)4.18672049
25complement activation, alternative pathway (GO:0006957)4.11134390
26glycine metabolic process (GO:0006544)4.10821105
27sulfate transmembrane transport (GO:1902358)4.09451347
28regulation of protein activation cascade (GO:2000257)4.05643293
29trivalent inorganic anion homeostasis (GO:0072506)4.05383475
30phosphate ion homeostasis (GO:0055062)4.05383475
31detection of external biotic stimulus (GO:0098581)4.04677923
32positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.95884314
33oxidative demethylation (GO:0070989)3.95422071
34amino-acid betaine metabolic process (GO:0006577)3.90895821
35superoxide anion generation (GO:0042554)3.89906931
36indole-containing compound catabolic process (GO:0042436)3.85945131
37indolalkylamine catabolic process (GO:0046218)3.85945131
38tryptophan catabolic process (GO:0006569)3.85945131
39S-adenosylmethionine metabolic process (GO:0046500)3.82803115
40regulation of activation of Janus kinase activity (GO:0010533)3.82113576
41regulation of complement activation (GO:0030449)3.82097637
42bile acid biosynthetic process (GO:0006699)3.76919611
43auditory receptor cell stereocilium organization (GO:0060088)3.72881729
44drug metabolic process (GO:0017144)3.71171156
45cellular ketone body metabolic process (GO:0046950)3.68099676
46positive regulation of cellular amide metabolic process (GO:0034250)3.67229370
47negative regulation of cholesterol transport (GO:0032375)3.65654360
48negative regulation of sterol transport (GO:0032372)3.65654360
49excretion (GO:0007588)3.65371562
50platelet dense granule organization (GO:0060155)3.64584427
51toxin transport (GO:1901998)3.61312211
52sulfate transport (GO:0008272)3.57044466
53flavonoid metabolic process (GO:0009812)3.53764052
54detection of biotic stimulus (GO:0009595)3.47291278
55serine family amino acid metabolic process (GO:0009069)3.45164242
56CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.38302260
57urate metabolic process (GO:0046415)3.35209863
58tryptophan metabolic process (GO:0006568)3.33104469
59thyroid hormone generation (GO:0006590)3.32108607
60branched-chain amino acid catabolic process (GO:0009083)3.29372146
61definitive hemopoiesis (GO:0060216)3.28316586
62negative regulation of nitric oxide biosynthetic process (GO:0045019)3.28115492
63bile acid metabolic process (GO:0008206)3.27905701
64interferon-gamma production (GO:0032609)3.23455210
65phenylpropanoid metabolic process (GO:0009698)3.23281385
66phospholipid scrambling (GO:0017121)3.21728680
67ketone body metabolic process (GO:1902224)3.20841519
68alpha-amino acid catabolic process (GO:1901606)3.18502214
69ethanol oxidation (GO:0006069)3.17239610
70sodium-independent organic anion transport (GO:0043252)3.17047404
71kynurenine metabolic process (GO:0070189)3.16150442
72positive regulation of uterine smooth muscle contraction (GO:0070474)3.15803802
73response to nitrosative stress (GO:0051409)3.13930686
74aromatic amino acid family metabolic process (GO:0009072)3.12358536
75serine family amino acid biosynthetic process (GO:0009070)3.11213844
76aldehyde catabolic process (GO:0046185)3.10897225
77high-density lipoprotein particle remodeling (GO:0034375)3.10628796
78reverse cholesterol transport (GO:0043691)3.10385108
79methionine metabolic process (GO:0006555)3.08817198
80methionine biosynthetic process (GO:0009086)3.08626803
81response to interferon-beta (GO:0035456)3.04112972
82regulation of fibrinolysis (GO:0051917)3.02273513
83blood coagulation, intrinsic pathway (GO:0007597)3.01449257
84indolalkylamine metabolic process (GO:0006586)3.01315413
85detection of other organism (GO:0098543)3.00978310
86xenobiotic catabolic process (GO:0042178)3.00653819
87endosome to pigment granule transport (GO:0043485)3.00028468
88endosome to melanosome transport (GO:0035646)3.00028468
89drug transmembrane transport (GO:0006855)2.99247162
90triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.98388230
91defense response to protozoan (GO:0042832)2.98329576
92negative regulation of lipase activity (GO:0060192)2.96730933
93thyroid hormone metabolic process (GO:0042403)2.96277000
94positive regulation of heat generation (GO:0031652)2.95598276
95phospholipid homeostasis (GO:0055091)2.93679425
96L-serine metabolic process (GO:0006563)2.92560207
97phospholipid efflux (GO:0033700)2.92344435
98mast cell activation (GO:0045576)2.91220589
99imidazole-containing compound metabolic process (GO:0052803)2.87096715
100urea metabolic process (GO:0019627)2.86699587
101regulation of fever generation (GO:0031620)2.86512442
102lipoxygenase pathway (GO:0019372)2.85618157
103sulfur amino acid biosynthetic process (GO:0000097)2.85360381
104negative regulation of macroautophagy (GO:0016242)2.85211597
105indole-containing compound metabolic process (GO:0042430)2.84850067
106positive regulation of interleukin-1 beta secretion (GO:0050718)2.84081105
107triglyceride homeostasis (GO:0070328)2.84072291
108acylglycerol homeostasis (GO:0055090)2.84072291
109metanephric nephron tubule development (GO:0072234)2.82676780
110metanephric tubule development (GO:0072170)2.82676780
111cellular amino acid catabolic process (GO:0009063)2.81545563
112regulation of cholesterol esterification (GO:0010872)2.81139649
113L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.79488992
114quaternary ammonium group transport (GO:0015697)2.77691572
115mature B cell differentiation involved in immune response (GO:0002313)2.77481217
116response to protozoan (GO:0001562)2.77448266
117cellular response to exogenous dsRNA (GO:0071360)2.76350273
118protein carboxylation (GO:0018214)2.75626264
119peptidyl-glutamic acid carboxylation (GO:0017187)2.75626264
120positive regulation of T cell mediated cytotoxicity (GO:0001916)2.74461149
121detection of bacterium (GO:0016045)2.73478746
122neutrophil activation involved in immune response (GO:0002283)2.72599645
123anterior/posterior axis specification, embryo (GO:0008595)2.72079411
124primary alcohol catabolic process (GO:0034310)2.71768749
125T cell lineage commitment (GO:0002360)2.69897329
126arginine metabolic process (GO:0006525)2.69195479
127branched-chain amino acid metabolic process (GO:0009081)2.67281716
128phosphate ion transport (GO:0006817)2.67057565
129dendritic cell chemotaxis (GO:0002407)2.66263254
130amine catabolic process (GO:0009310)2.65953282
131cellular biogenic amine catabolic process (GO:0042402)2.65953282
132cysteine metabolic process (GO:0006534)2.65634759
133positive regulation of gamma-delta T cell activation (GO:0046645)2.65238982
134post-embryonic morphogenesis (GO:0009886)2.64964952
135inner ear receptor stereocilium organization (GO:0060122)2.63547807
136regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.63187871
137type I interferon signaling pathway (GO:0060337)2.62847966
138cellular response to type I interferon (GO:0071357)2.62847966
139response to peptidoglycan (GO:0032494)2.62241434
140negative regulation of protein activation cascade (GO:2000258)2.62172708
141negative regulation of mast cell activation (GO:0033004)2.61566201
142response to type I interferon (GO:0034340)2.59809311
143activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.59520628
144positive regulation of interleukin-1 secretion (GO:0050716)2.59390436
145nitrogen cycle metabolic process (GO:0071941)2.57747666
146glutamate metabolic process (GO:0006536)2.57657227
147cholesterol efflux (GO:0033344)2.57207085
148negative regulation of viral genome replication (GO:0045071)2.57020930
149aspartate family amino acid biosynthetic process (GO:0009067)2.56517779
150positive regulation of interleukin-10 production (GO:0032733)2.55782947
151macrophage activation (GO:0042116)2.54033302
152dendritic cell migration (GO:0036336)2.52737215
153cellular response to interferon-beta (GO:0035458)2.50950541
154megakaryocyte development (GO:0035855)2.48932927
155ceramide catabolic process (GO:0046514)2.48367490
156positive regulation of lymphocyte migration (GO:2000403)2.48359804
157positive regulation of vascular permeability (GO:0043117)2.47843578
158response to interferon-alpha (GO:0035455)2.47436702
159lymphoid progenitor cell differentiation (GO:0002320)2.47260960
160regulation of B cell receptor signaling pathway (GO:0050855)2.46711023
161phagocytosis, engulfment (GO:0006911)2.46242304
162bone remodeling (GO:0046849)2.45020379
163regulation of heat generation (GO:0031650)2.43501807
164positive regulation of T cell migration (GO:2000406)2.43472577
165fat-soluble vitamin catabolic process (GO:0042363)2.42442440
166vitamin catabolic process (GO:0009111)2.42442440
167lymph node development (GO:0048535)2.41739504
168regulation of interleukin-1 beta secretion (GO:0050706)2.40736895
169regulation of interleukin-6 biosynthetic process (GO:0045408)2.40716361
170sulfur compound transport (GO:0072348)2.40681680
171mesenchymal cell differentiation involved in kidney development (GO:0072161)2.39947658
172mesenchymal cell differentiation involved in renal system development (GO:2001012)2.39947658
173mesonephros development (GO:0001823)2.39796445
174positive regulation of protein sumoylation (GO:0033235)2.38669864
175positive regulation of T cell chemotaxis (GO:0010820)2.38099871
176regulation of T cell chemotaxis (GO:0010819)2.38099871
177positive regulation of icosanoid secretion (GO:0032305)2.35104783
178histamine transport (GO:0051608)2.34659770
179oligosaccharide catabolic process (GO:0009313)2.34507631
180neutrophil activation (GO:0042119)2.34326413
181monocyte chemotaxis (GO:0002548)2.33424266
182natural killer cell activation involved in immune response (GO:0002323)2.32451230
183leukocyte aggregation (GO:0070486)2.32074594
184regulation of chemokine biosynthetic process (GO:0045073)2.32038430
185positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.31686646
186positive regulation of prostaglandin secretion (GO:0032308)2.31028895
187superoxide metabolic process (GO:0006801)2.30695650
188cell differentiation involved in metanephros development (GO:0072202)2.30632134
189positive regulation of antigen processing and presentation (GO:0002579)2.30181812
190myeloid dendritic cell activation (GO:0001773)2.28382347
191daunorubicin metabolic process (GO:0044597)11.4054287
192polyketide metabolic process (GO:0030638)11.4054287
193doxorubicin metabolic process (GO:0044598)11.4054287

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.62066185
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.79292173
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.52760320
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.14145381
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.14070091
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.09151181
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.06462723
8GBX2_23144817_ChIP-Seq_PC3_Human2.92833452
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.81962195
10SCL_19346495_ChIP-Seq_HPC-7_Human2.75368793
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.70618506
12ZNF274_21170338_ChIP-Seq_K562_Hela2.66767319
13LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.60191637
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.56824243
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47988021
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.39627230
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.37346427
18CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.35293071
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.30203672
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.24244192
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.17185583
22SUZ12_27294783_Chip-Seq_NPCs_Mouse2.09804158
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.08198253
24FUS_26573619_Chip-Seq_HEK293_Human2.06864093
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.02583864
26NFE2_27457419_Chip-Seq_LIVER_Mouse2.00051538
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.98329721
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.94277293
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90829035
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88814112
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.85000089
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.81915392
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.79479693
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79372541
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.77048644
36IGF1R_20145208_ChIP-Seq_DFB_Human1.74277173
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.74228347
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.67394186
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.66541383
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65879513
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.65324003
42* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64977759
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.64386018
44RUNX_20019798_ChIP-Seq_JUKART_Human1.64076557
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62827778
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61419845
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.60540925
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58433361
49RXR_22158963_ChIP-Seq_LIVER_Mouse1.57893761
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54572316
51SUZ12_18555785_Chip-Seq_ESCs_Mouse1.53170914
52BCAT_22108803_ChIP-Seq_LS180_Human1.49609607
53STAT3_18555785_Chip-Seq_ESCs_Mouse1.49606388
54CBP_20019798_ChIP-Seq_JUKART_Human1.49151814
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49151814
56EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.49014769
57LXR_22158963_ChIP-Seq_LIVER_Mouse1.48824679
58ELK1_19687146_ChIP-ChIP_HELA_Human1.48642287
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48408165
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47681585
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.46714996
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.46455519
63E2F1_18555785_Chip-Seq_ESCs_Mouse1.46136631
64P53_22387025_ChIP-Seq_ESCs_Mouse1.46066145
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46033532
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.44122565
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43137511
68HTT_18923047_ChIP-ChIP_STHdh_Human1.42968594
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42433350
70* P300_19829295_ChIP-Seq_ESCs_Human1.42129139
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.40248792
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39614867
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39423426
74OCT4_18555785_Chip-Seq_ESCs_Mouse1.38321434
75NMYC_18555785_Chip-Seq_ESCs_Mouse1.37677442
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.37119622
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37001027
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36196648
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.36137406
80NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35345789
81TCF4_22108803_ChIP-Seq_LS180_Human1.35153991
82* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34591194
83RUNX1_27457419_Chip-Seq_LIVER_Mouse1.34483270
84STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32613773
85SMAD4_21799915_ChIP-Seq_A2780_Human1.32473199
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32333518
87STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31443406
88VDR_24787735_ChIP-Seq_THP-1_Human1.31186276
89ZFX_18555785_Chip-Seq_ESCs_Mouse1.30169119
90STAT3_23295773_ChIP-Seq_U87_Human1.29712903
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29693921
92PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29518614
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29206666
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29024524
95P300_18555785_Chip-Seq_ESCs_Mouse1.28743049
96EST1_17652178_ChIP-ChIP_JURKAT_Human1.27959465
97TAF15_26573619_Chip-Seq_HEK293_Human1.27011154
98SOX2_18555785_Chip-Seq_ESCs_Mouse1.26812854
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26004753
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.25738291
101EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24533955
102FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23607218
103RNF2_27304074_Chip-Seq_NSC_Mouse1.23461698
104CMYC_18555785_Chip-Seq_ESCs_Mouse1.22966722
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22952178
106OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22781247
107CDX2_22108803_ChIP-Seq_LS180_Human1.22615219
108PU1_27457419_Chip-Seq_LIVER_Mouse1.22395006
109SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22365376
110PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21776690
111ESRRB_18555785_Chip-Seq_ESCs_Mouse1.21074195
112CRX_20693478_ChIP-Seq_RETINA_Mouse1.20992924
113IRF1_19129219_ChIP-ChIP_H3396_Human1.20905290
114RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20451707
115SOX2_19829295_ChIP-Seq_ESCs_Human1.18887363
116NANOG_19829295_ChIP-Seq_ESCs_Human1.18887363
117PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18194369
118EWS_26573619_Chip-Seq_HEK293_Human1.18120829
119* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16841777
120SMAD4_21741376_ChIP-Seq_EPCs_Human1.16279295
121CTCF_18555785_Chip-Seq_ESCs_Mouse1.16157112
122SMAD1_18555785_Chip-Seq_ESCs_Mouse1.15744648
123FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15372635
124KLF4_18555785_Chip-Seq_ESCs_Mouse1.15367879
125TCF4_23295773_ChIP-Seq_U87_Human1.15347436
126CBX2_27304074_Chip-Seq_ESCs_Mouse1.14661009
127AR_21909140_ChIP-Seq_LNCAP_Human1.14444996
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13972730
129KAP1_22055183_ChIP-Seq_ESCs_Mouse1.13139271
130EED_16625203_ChIP-ChIP_MESCs_Mouse1.12910389
131SPI1_23547873_ChIP-Seq_NB4_Human1.12624682
132* TP53_22573176_ChIP-Seq_HFKS_Human1.12208443
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12172449
134POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11080790
135NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10493686
136KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10092519
137RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08607632
138CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08107354
139AR_20517297_ChIP-Seq_VCAP_Human1.06917683
140JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05371431
141TAL1_26923725_Chip-Seq_HPCs_Mouse1.05278754
142CDX2_20551321_ChIP-Seq_CACO-2_Human1.05204402
143MYC_18940864_ChIP-ChIP_HL60_Human1.05175197
144E2F4_17652178_ChIP-ChIP_JURKAT_Human1.05097382
145OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04992853
146NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04873826
147VDR_22108803_ChIP-Seq_LS180_Human1.04396826
148PIAS1_25552417_ChIP-Seq_VCAP_Human1.03494966
149PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02730265
150GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02575752
151EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02190967
152HNF4A_19822575_ChIP-Seq_HepG2_Human1.01505817
153GATA4_25053715_ChIP-Seq_YYC3_Human1.01085425
154* RUNX2_22187159_ChIP-Seq_PCA_Human1.01067734
155PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00806458
156CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00195372
157TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99906932
158* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99205024
159CBP_21632823_ChIP-Seq_H3396_Human0.98196246
160NANOG_16153702_ChIP-ChIP_HESCs_Human0.96760100
161FOXA1_25329375_ChIP-Seq_VCAP_Human0.96414695
162FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96414695
163AR_21572438_ChIP-Seq_LNCaP_Human0.96163802
164FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95170982
165PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94536294
166VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93886796
167ER_23166858_ChIP-Seq_MCF-7_Human0.92769576
168CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92158466
169SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91474543
170NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91357807
171AR_25329375_ChIP-Seq_VCAP_Human0.89829115

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.24853847
2MP0005377_hearing/vestibular/ear_phenot4.14356371
3MP0003878_abnormal_ear_physiology4.14356371
4MP0008004_abnormal_stomach_pH3.74866509
5MP0005085_abnormal_gallbladder_physiolo3.41347039
6MP0003252_abnormal_bile_duct3.30355991
7MP0005365_abnormal_bile_salt3.17465392
8MP0001835_abnormal_antigen_presentation3.06124287
9MP0006292_abnormal_olfactory_placode3.04571009
10MP0009697_abnormal_copulation2.83528286
11MP0005360_urolithiasis2.80629061
12MP0008875_abnormal_xenobiotic_pharmacok2.74890619
13MP0009785_altered_susceptibility_to2.67705550
14MP0002148_abnormal_hypersensitivity_rea2.62451910
15MP0002396_abnormal_hematopoietic_system2.47433570
16MP0003890_abnormal_embryonic-extraembry2.47085024
17MP0002277_abnormal_respiratory_mucosa2.43290471
18MP0005671_abnormal_response_to2.31084629
19MP0000566_synostosis2.30232863
20MP0005332_abnormal_amino_acid2.27201268
21MP0005645_abnormal_hypothalamus_physiol2.23894522
22MP0002132_abnormal_respiratory_system2.11228157
23MP0005310_abnormal_salivary_gland2.05209283
24MP0001756_abnormal_urination2.02949609
25MP0009764_decreased_sensitivity_to1.94321661
26MP0000678_abnormal_parathyroid_gland1.93884765
27MP0002419_abnormal_innate_immunity1.91072605
28MP0001986_abnormal_taste_sensitivity1.90624326
29MP0001666_abnormal_nutrient_absorption1.86923788
30MP0003941_abnormal_skin_development1.86862210
31MP0001790_abnormal_immune_system1.86110074
32MP0005387_immune_system_phenotype1.86110074
33MP0003879_abnormal_hair_cell1.85978113
34MP0005025_abnormal_response_to1.85458971
35MP0002928_abnormal_bile_duct1.81680285
36MP0003724_increased_susceptibility_to1.74566400
37MP0004742_abnormal_vestibular_system1.69941216
38MP0005174_abnormal_tail_pigmentation1.67597484
39MP0004019_abnormal_vitamin_homeostasis1.66808530
40MP0009643_abnormal_urine_homeostasis1.63469016
41MP0008872_abnormal_physiological_respon1.62750155
42MP0000685_abnormal_immune_system1.61726351
43MP0002723_abnormal_immune_serum1.61469996
44MP0002452_abnormal_antigen_presenting1.61431673
45MP0005000_abnormal_immune_tolerance1.60366982
46MP0000681_abnormal_thyroid_gland1.57308371
47MP0002254_reproductive_system_inflammat1.57258568
48MP0005646_abnormal_pituitary_gland1.56571627
49MP0006082_CNS_inflammation1.54986686
50MP0004782_abnormal_surfactant_physiolog1.54386140
51MP0002876_abnormal_thyroid_physiology1.52209051
52MP0005075_abnormal_melanosome_morpholog1.50909159
53MP0010329_abnormal_lipoprotein_level1.50549086
54MP0008057_abnormal_DNA_replication1.50358998
55MP0001800_abnormal_humoral_immune1.47093364
56MP0004147_increased_porphyrin_level1.45636749
57MP0001819_abnormal_immune_cell1.44463692
58MP0002420_abnormal_adaptive_immunity1.43616599
59MP0005464_abnormal_platelet_physiology1.41846187
60MP0001873_stomach_inflammation1.40189975
61MP0005171_absent_coat_pigmentation1.40184918
62MP0001188_hyperpigmentation1.39649398
63MP0003436_decreased_susceptibility_to1.37263354
64MP0003718_maternal_effect1.33963382
65MP0005670_abnormal_white_adipose1.32340827
66MP0000015_abnormal_ear_pigmentation1.31464023
67MP0005409_darkened_coat_color1.26505467
68MP0010678_abnormal_skin_adnexa1.26483401
69MP0004043_abnormal_pH_regulation1.22838646
70MP0001485_abnormal_pinna_reflex1.20222860
71MP0005220_abnormal_exocrine_pancreas1.19466042
72MP0008877_abnormal_DNA_methylation1.18137556
73MP0003763_abnormal_thymus_physiology1.17675589
74MP0002095_abnormal_skin_pigmentation1.17625313
75MP0004264_abnormal_extraembryonic_tissu1.15825170
76MP0005408_hypopigmentation1.15330050
77MP0002998_abnormal_bone_remodeling1.15299646
78MP0001984_abnormal_olfaction1.12923973
79MP0008058_abnormal_DNA_repair1.12658071
80MP0005395_other_phenotype1.10297935
81MP0010155_abnormal_intestine_physiology1.09987711
82MP0002938_white_spotting1.09333459
83MP0001845_abnormal_inflammatory_respons1.08193378
84MP0002138_abnormal_hepatobiliary_system1.07125412
85MP0010030_abnormal_orbit_morphology1.06526372
86MP0000716_abnormal_immune_system1.05865962
87MP0010386_abnormal_urinary_bladder1.05575176
88MP0005551_abnormal_eye_electrophysiolog1.05168028
89MP0001293_anophthalmia1.03520874
90MP0001765_abnormal_ion_homeostasis1.03317594
91MP0000490_abnormal_crypts_of1.03219166
92MP0008961_abnormal_basal_metabolism1.03004022
93MP0002098_abnormal_vibrissa_morphology1.01683590
94MP0008469_abnormal_protein_level1.01627236
95MP0008260_abnormal_autophagy1.00150232
96MP0004381_abnormal_hair_follicle0.99776531
97MP0000427_abnormal_hair_cycle0.99695217
98MP0002075_abnormal_coat/hair_pigmentati0.99244873
99MP0003693_abnormal_embryo_hatching0.99110514
100MP0002398_abnormal_bone_marrow0.97256201
101MP0003866_abnormal_defecation0.96270592
102MP0005084_abnormal_gallbladder_morpholo0.95935474
103MP0002405_respiratory_system_inflammati0.95421887
104MP0008995_early_reproductive_senescence0.95280783
105MP0004133_heterotaxia0.95162903
106MP0002136_abnormal_kidney_physiology0.95123451
107MP0003937_abnormal_limbs/digits/tail_de0.94733837
108MP0000372_irregular_coat_pigmentation0.94616394
109MP0003868_abnormal_feces_composition0.93767977
110MP0001186_pigmentation_phenotype0.92315430
111MP0003943_abnormal_hepatobiliary_system0.90917777
112MP0001664_abnormal_digestion0.90482275
113MP0002736_abnormal_nociception_after0.88503513
114MP0000647_abnormal_sebaceous_gland0.87976538
115MP0002638_abnormal_pupillary_reflex0.85962461
116MP0002163_abnormal_gland_morphology0.85893613
117MP0003136_yellow_coat_color0.83650474
118MP0010368_abnormal_lymphatic_system0.83394093
119MP0002429_abnormal_blood_cell0.83269523
120MP0002168_other_aberrant_phenotype0.83080403
121MP0003186_abnormal_redox_activity0.82925625
122MP0003828_pulmonary_edema0.82804310
123MP0003806_abnormal_nucleotide_metabolis0.82715344
124MP0002233_abnormal_nose_morphology0.82125250
125MP0005397_hematopoietic_system_phenotyp0.81783250
126MP0001545_abnormal_hematopoietic_system0.81783250
127MP0003119_abnormal_digestive_system0.81279328
128MP0004808_abnormal_hematopoietic_stem0.80042966
129MP0000689_abnormal_spleen_morphology0.79107938
130MP0010094_abnormal_chromosome_stability0.78679404
131MP0000371_diluted_coat_color0.77961284
132MP0001661_extended_life_span0.76818664
133MP0002160_abnormal_reproductive_system0.76204460
134MP0002697_abnormal_eye_size0.75983446
135MP0005166_decreased_susceptibility_to0.75692636
136MP0005187_abnormal_penis_morphology0.75131059
137MP0004957_abnormal_blastocyst_morpholog0.75092360
138MP0005636_abnormal_mineral_homeostasis0.74957522
139MP0002102_abnormal_ear_morphology0.74103725
140MP0002118_abnormal_lipid_homeostasis0.73587358
141MP0001764_abnormal_homeostasis0.73188963
142MP0001929_abnormal_gametogenesis0.73181278
143MP0003195_calcinosis0.72725991
144MP0001346_abnormal_lacrimal_gland0.72713642
145MP0000383_abnormal_hair_follicle0.71507806
146MP0000631_abnormal_neuroendocrine_gland0.71473105
147MP0000470_abnormal_stomach_morphology0.71349229
148MP0002090_abnormal_vision0.71304777
149MP0009703_decreased_birth_body0.70767406
150MP0002722_abnormal_immune_system0.70112508
151MP0005253_abnormal_eye_physiology0.69884323
152MP0005647_abnormal_sex_gland0.69399458
153MP0000465_gastrointestinal_hemorrhage0.69384301
154MP0003938_abnormal_ear_development0.68296942
155MP0001286_abnormal_eye_development0.66485672
156MP0002084_abnormal_developmental_patter0.65684154
157MP0000538_abnormal_urinary_bladder0.65395471
158MP0000609_abnormal_liver_physiology0.65340117
159MP0003698_abnormal_male_reproductive0.63073804
160MP0000653_abnormal_sex_gland0.62905893
161MP0009672_abnormal_birth_weight0.62628139
162MP0006072_abnormal_retinal_apoptosis0.62321524
163MP0003567_abnormal_fetal_cardiomyocyte0.62085179
164MP0005410_abnormal_fertilization0.61332338
165MP0001270_distended_abdomen0.58570567
166MP0001324_abnormal_eye_pigmentation0.58220037
167MP0005319_abnormal_enzyme/_coenzyme0.57626462
168MP0002210_abnormal_sex_determination0.57511106
169MP0004215_abnormal_myocardial_fiber0.57426325
170MP0001145_abnormal_male_reproductive0.54815183

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)4.43996625
2Unilateral renal agenesis (HP:0000122)4.24152529
3Metabolic alkalosis (HP:0200114)3.79530489
4Alopecia of scalp (HP:0002293)3.76181561
5Proximal tubulopathy (HP:0000114)3.71416638
6Tetany (HP:0001281)3.69862342
7Hyperactive renin-angiotensin system (HP:0000841)3.63987583
8Gout (HP:0001997)3.56857666
9Prolonged partial thromboplastin time (HP:0003645)3.56630805
10Bilateral sensorineural hearing impairment (HP:0008619)3.36598510
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.27064940
12Absent/shortened dynein arms (HP:0200106)3.27025672
13Dynein arm defect of respiratory motile cilia (HP:0012255)3.27025672
14Hypokalemia (HP:0002900)3.26943585
15Prostate neoplasm (HP:0100787)3.18546910
16Hyperglycinemia (HP:0002154)3.14508817
17Abnormality of dental color (HP:0011073)3.11230785
18Hyperglycinuria (HP:0003108)3.09511533
19Cheilitis (HP:0100825)3.09344279
20Hypobetalipoproteinemia (HP:0003563)3.04602498
21Abnormality of monocarboxylic acid metabolism (HP:0010996)3.00659529
22Chromsome breakage (HP:0040012)2.98453873
23Intrahepatic cholestasis (HP:0001406)2.98125306
24Abnormality of chloride homeostasis (HP:0011422)2.96601733
25Glycosuria (HP:0003076)2.95827287
26Abnormality of urine glucose concentration (HP:0011016)2.95827287
27Hyperaldosteronism (HP:0000859)2.94019174
28Complement deficiency (HP:0004431)2.92106346
29Abnormality of serine family amino acid metabolism (HP:0010894)2.91376381
30Abnormality of glycine metabolism (HP:0010895)2.91376381
31Abnormality of aromatic amino acid family metabolism (HP:0004338)2.90749302
32Follicular hyperkeratosis (HP:0007502)2.88586508
33Hypokalemic alkalosis (HP:0001949)2.83553494
34Chronic otitis media (HP:0000389)2.82482550
35Hyperphosphaturia (HP:0003109)2.82331896
36Myositis (HP:0100614)2.79281583
37Recurrent abscess formation (HP:0002722)2.78463691
38Type 2 muscle fiber atrophy (HP:0003554)2.77066244
39Retrobulbar optic neuritis (HP:0100654)2.76936321
40Optic neuritis (HP:0100653)2.76936321
41Hypomagnesemia (HP:0002917)2.72747383
42Patchy hypopigmentation of hair (HP:0011365)2.69814727
43Abnormality of renal excretion (HP:0011036)2.67971707
44Hyperphosphatemia (HP:0002905)2.67144801
45Polyuria (HP:0000103)2.66584290
46Tubular atrophy (HP:0000092)2.65678733
47Renal cortical cysts (HP:0000803)2.56782429
48Pancreatic cysts (HP:0001737)2.56584790
49Abnormality of renin-angiotensin system (HP:0000847)2.54166087
50White forelock (HP:0002211)2.52195394
51Hypothermia (HP:0002045)2.47850115
52Abnormality of the prostate (HP:0008775)2.46033127
53Thyroid-stimulating hormone excess (HP:0002925)2.45624299
54Abnormality of potassium homeostasis (HP:0011042)2.43079346
55Hypercalciuria (HP:0002150)2.42787445
56Ectropion (HP:0000656)2.41205291
57Enlarged kidneys (HP:0000105)2.39449316
58Abnormal urine output (HP:0012590)2.39291924
59Abnormal respiratory motile cilium morphology (HP:0005938)2.39161089
60Abnormal respiratory epithelium morphology (HP:0012253)2.39161089
61Abnormality of magnesium homeostasis (HP:0004921)2.37945323
62Orchitis (HP:0100796)2.37796303
63Petechiae (HP:0000967)2.37206887
64Recurrent bacterial skin infections (HP:0005406)2.34061506
65Eczematoid dermatitis (HP:0000976)2.33774912
66Abnormal ciliary motility (HP:0012262)2.33589408
67Recurrent corneal erosions (HP:0000495)2.33318979
68Abnormality of serum amino acid levels (HP:0003112)2.32625999
69Spontaneous abortion (HP:0005268)2.31254472
70Renal tubular acidosis (HP:0001947)2.30959533
71Deep venous thrombosis (HP:0002625)2.30704512
72Abnormality of the renal collecting system (HP:0004742)2.30041598
73Abnormal drinking behavior (HP:0030082)2.26934146
74Polydipsia (HP:0001959)2.26934146
75Muscle fiber atrophy (HP:0100295)2.26882594
76Nonprogressive disorder (HP:0003680)2.26149562
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25943385
78Abnormality of alanine metabolism (HP:0010916)2.25943385
79Hyperalaninemia (HP:0003348)2.25943385
80Abnormality of macrophages (HP:0004311)2.25484312
81Hypergonadotropic hypogonadism (HP:0000815)2.25283992
82Abnormal urine phosphate concentration (HP:0012599)2.24857883
83Type I transferrin isoform profile (HP:0003642)2.24415903
84Alkalosis (HP:0001948)2.21225450
85Reduced antithrombin III activity (HP:0001976)2.20816130
86Abnormality of purine metabolism (HP:0004352)2.20780290
87Keratitis (HP:0000491)2.19350853
88Vacuolated lymphocytes (HP:0001922)2.19205774
89Abnormality of the renal cortex (HP:0011035)2.19201381
90Abnormality of nucleobase metabolism (HP:0010932)2.18779777
91Prolonged bleeding time (HP:0003010)2.17729947
92Chronic diarrhea (HP:0002028)2.17456768
93Abnormality of aspartate family amino acid metabolism (HP:0010899)2.16400811
94Abnormality of pyrimidine metabolism (HP:0004353)2.14415019
95IgM deficiency (HP:0002850)2.13762687
96Duplicated collecting system (HP:0000081)2.13754030
97Abnormality of the renal medulla (HP:0100957)2.13079292
98Abnormality of methionine metabolism (HP:0010901)2.12478532
99Prolonged neonatal jaundice (HP:0006579)2.11445986
100Hypolipoproteinemia (HP:0010981)2.11385125
101Nephrogenic diabetes insipidus (HP:0009806)2.09446012
102Clubbing of toes (HP:0100760)2.09073795
103Renal tubular dysfunction (HP:0000124)2.06513242
104Goiter (HP:0000853)2.05696895
105Albinism (HP:0001022)2.05281351
106Facial shape deformation (HP:0011334)2.05192608
107Potter facies (HP:0002009)2.05192608
108Abnormality of renal resorption (HP:0011038)2.04954326
109Abnormality of fatty-acid metabolism (HP:0004359)2.03817098
110Increased circulating renin level (HP:0000848)2.02551054
111Congenital sensorineural hearing impairment (HP:0008527)2.02249979
112Absent eyebrow (HP:0002223)1.99988222
113Alveolar cell carcinoma (HP:0006519)1.99139949
114Conical tooth (HP:0000698)1.98770372
115Renal dysplasia (HP:0000110)1.97132777
116Increased purine levels (HP:0004368)1.92438921
117Hyperuricemia (HP:0002149)1.92438921
118Abolished electroretinogram (ERG) (HP:0000550)1.90544944
119Abnormal biliary tract physiology (HP:0012439)1.89691724
120Bile duct proliferation (HP:0001408)1.89691724
121Generalized aminoaciduria (HP:0002909)1.89240648
122Abnormality of glutamine family amino acid metabolism (HP:0010902)1.89179731
123Decreased circulating renin level (HP:0003351)1.88676068
124Recurrent fungal infections (HP:0002841)1.87966925
125Recurrent pneumonia (HP:0006532)1.85847740
126Rickets (HP:0002748)1.85455108
127Abnormality of complement system (HP:0005339)1.85126839
128Absent rod-and cone-mediated responses on ERG (HP:0007688)1.84951025
129Pancytopenia (HP:0001876)1.84529240
130Fair hair (HP:0002286)1.84326539
131Erythroderma (HP:0001019)1.83391687
132Absent eyelashes (HP:0000561)1.83110009
133Reticulocytopenia (HP:0001896)1.82656927
134Dry hair (HP:0011359)1.82625624
135Conjugated hyperbilirubinemia (HP:0002908)1.82460188
136Chronic mucocutaneous candidiasis (HP:0002728)1.82323417
137Recurrent cutaneous fungal infections (HP:0011370)1.82323417
138Osteomalacia (HP:0002749)1.82145712
139Chronic sinusitis (HP:0011109)1.79965519
140Abnormality of DNA repair (HP:0003254)1.79660916
141Encephalitis (HP:0002383)1.78996232
142Mediastinal lymphadenopathy (HP:0100721)1.78857206
143Obstructive lung disease (HP:0006536)1.78649651
144Chronic obstructive pulmonary disease (HP:0006510)1.78649651
145Renal salt wasting (HP:0000127)1.78231400
146Delayed CNS myelination (HP:0002188)1.78018608
147Vertigo (HP:0002321)1.77934787
148Elevated erythrocyte sedimentation rate (HP:0003565)1.76873292
149True hermaphroditism (HP:0010459)1.76263008
150Nephrocalcinosis (HP:0000121)1.72340784
151Genital tract atresia (HP:0001827)1.71612054
152Vaginal atresia (HP:0000148)1.71220537
153Hypoalphalipoproteinemia (HP:0003233)1.69922799
154Hypophosphatemic rickets (HP:0004912)1.69612379
155Intestinal atresia (HP:0011100)1.67800936
156Hyperammonemia (HP:0001987)1.67137754
157Lethargy (HP:0001254)1.67130242
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.66881180
159Cystic liver disease (HP:0006706)1.65375386
160Abnormal pancreas size (HP:0012094)1.64792178
161Abnormality of the intrinsic pathway (HP:0010989)1.64464280
162Bicornuate uterus (HP:0000813)1.63964232
163Absent radius (HP:0003974)1.62845965
164Joint hemorrhage (HP:0005261)1.62721464
165Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.61278654
166Labial hypoplasia (HP:0000066)1.57347653
167Absent forearm bone (HP:0003953)1.55901085
168Aplasia involving forearm bones (HP:0009822)1.55901085
169Abnormality of sulfur amino acid metabolism (HP:0004339)1.52490882
170Vascular calcification (HP:0004934)1.51930987
171Gonadotropin excess (HP:0000837)1.51685550
172Abnormality of sodium homeostasis (HP:0010931)1.51452541
173Chronic hepatic failure (HP:0100626)1.50572212
174Medial flaring of the eyebrow (HP:0010747)1.49548106

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK34.78493005
2FRK3.44477706
3TNIK3.41151402
4TXK2.99300710
5TRIM282.97894087
6MAP3K142.87083051
7MAP3K122.74181518
8STK162.63272030
9MAP4K22.54038395
10ADRBK22.49472567
11PBK2.39473028
12TIE12.36290005
13MUSK2.36208086
14TGFBR22.30825262
15CDK82.20639608
16MAP3K42.14618738
17PDK22.11905566
18IRAK42.00691889
19IRAK31.92721238
20KIT1.88050138
21TEC1.87052336
22BMPR1B1.79760899
23SIK21.78491330
24CASK1.77592590
25MKNK21.77247359
26ZAK1.76140945
27BCR1.71870248
28EPHA21.57257447
29OXSR11.53335568
30BRSK21.48414418
31TLK11.47445177
32SIK11.45956948
33BLK1.45822120
34IKBKE1.45167072
35EIF2AK21.39099690
36IKBKB1.37152041
37AKT31.36103366
38ERBB41.35232859
39PINK11.33343091
40SRPK11.30411272
41MAP4K11.29493363
42NLK1.29245714
43EIF2AK31.28941712
44PRPF4B1.24665378
45GRK71.22454506
46BTK1.21794108
47MKNK11.18217351
48NME21.17706571
49TBK11.14226687
50WNK31.13399015
51INSRR1.12392813
52BMPR21.11659524
53STK31.10721401
54TTK1.10617622
55BCKDK1.08598039
56MAP2K71.05916917
57JAK31.05691575
58WNK41.05483746
59STK38L0.97658945
60TGFBR10.97074780
61MST1R0.96395888
62CHUK0.91132587
63VRK10.88298754
64CDK190.88133052
65FGFR20.87176194
66MARK30.86383634
67NEK60.85980026
68CSF1R0.85288869
69PLK30.85050267
70MET0.84240374
71NEK90.84034627
72LYN0.84030012
73PIM20.83990756
74CDK30.82654748
75LMTK20.82235630
76MYLK0.81808867
77YES10.80589243
78RIPK40.80446453
79NUAK10.80204400
80CLK10.78655111
81PAK40.78384380
82TNK20.77760550
83GRK10.77389487
84SYK0.77197508
85FGFR10.75400709
86NEK10.75135224
87ZAP700.72616164
88CSNK1G10.71715994
89MAPK130.70141309
90TYK20.68778385
91NME10.68036897
92STK390.67101386
93PLK10.66984082
94TAOK30.65715792
95SGK4940.62232376
96IRAK10.61999899
97SGK20.61488742
98FER0.60222376
99LATS10.57475771
100CAMK10.57102739
101FLT30.54703408
102CSNK1A1L0.54487733
103MAP2K40.53398243
104VRK20.52579590
105NEK20.51533761
106ACVR1B0.51016408
107TAOK20.51010734
108PRKCG0.50623631
109PIM10.50319123
110LCK0.50313738
111PASK0.49641492
112MATK0.48853424
113TRPM70.48326681
114HCK0.47873541
115STK240.47602825
116EIF2AK10.47357490
117STK380.46697929
118MST40.44075933
119PIK3CG0.43813447
120PRKAA10.43736432
121SGK30.43675630
122MAPKAPK50.43309976
123MAPKAPK30.42865271
124MAPK150.42434043
125CSNK1G30.41680783
126PLK40.39732082
127BRSK10.39723030
128PRKG20.39606958
129CSNK1A10.38976806
130ATM0.38749521
131MELK0.37842477
132PAK30.37807239
133PRKCD0.37628269
134CSNK1G20.37544439
135PRKAA20.36159090
136PRKCE0.34977482
137RPS6KB10.33650926
138CDK70.31688530
139PNCK0.31594527
140PLK20.31492934
141PRKCI0.30701047
142CHEK20.29880097
143ABL10.29650281
144RPS6KB20.29419276
145ITK0.29127203
146TSSK60.28729100
147PIK3CA0.28527180
148WEE10.27934290
149KSR10.27578873
150CSNK2A10.25654369
151ATR0.25383303
152CSNK1E0.24751526
153MAP2K60.24505691
154ERBB30.23790975
155JAK10.23197133
156SGK2230.22491042

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31819511
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.19457092
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.03838376
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.81166178
5Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.79177423
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.68964618
7Allograft rejection_Homo sapiens_hsa053302.65586429
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.58559739
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.57816347
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.53405556
11Butanoate metabolism_Homo sapiens_hsa006502.39480614
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.38329290
13Graft-versus-host disease_Homo sapiens_hsa053322.31657087
14Primary immunodeficiency_Homo sapiens_hsa053402.30378929
15Caffeine metabolism_Homo sapiens_hsa002322.30120945
16Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.25949498
17Rheumatoid arthritis_Homo sapiens_hsa053232.17223327
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.16285129
19Autoimmune thyroid disease_Homo sapiens_hsa053202.15627115
20Complement and coagulation cascades_Homo sapiens_hsa046102.12939303
21Fatty acid degradation_Homo sapiens_hsa000712.11286865
22Propanoate metabolism_Homo sapiens_hsa006402.08443860
23Toll-like receptor signaling pathway_Homo sapiens_hsa046202.07118722
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06284256
25Tryptophan metabolism_Homo sapiens_hsa003802.04240392
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.03231254
27Vitamin digestion and absorption_Homo sapiens_hsa049772.02669566
28Hematopoietic cell lineage_Homo sapiens_hsa046402.02305943
29Other glycan degradation_Homo sapiens_hsa005111.97001527
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.96856764
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.93117163
32Measles_Homo sapiens_hsa051621.89314126
33Arachidonic acid metabolism_Homo sapiens_hsa005901.86778673
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.85301362
35Leishmaniasis_Homo sapiens_hsa051401.79754273
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.79046743
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.75528949
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.72498633
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.70210820
40Mineral absorption_Homo sapiens_hsa049781.67247922
41Phenylalanine metabolism_Homo sapiens_hsa003601.64765692
42Asthma_Homo sapiens_hsa053101.63687175
43Arginine biosynthesis_Homo sapiens_hsa002201.62163145
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.56649952
45Tyrosine metabolism_Homo sapiens_hsa003501.49512769
46Legionellosis_Homo sapiens_hsa051341.46082252
47Pyruvate metabolism_Homo sapiens_hsa006201.46049284
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45059704
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.42172365
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40567679
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.36220564
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34328899
53Steroid hormone biosynthesis_Homo sapiens_hsa001401.33387932
54Sphingolipid metabolism_Homo sapiens_hsa006001.31492460
55Herpes simplex infection_Homo sapiens_hsa051681.29130783
56Jak-STAT signaling pathway_Homo sapiens_hsa046301.25772372
57Type I diabetes mellitus_Homo sapiens_hsa049401.25615467
58Pertussis_Homo sapiens_hsa051331.24470771
59Starch and sucrose metabolism_Homo sapiens_hsa005001.21443021
60Malaria_Homo sapiens_hsa051441.20341151
61Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16743291
62Homologous recombination_Homo sapiens_hsa034401.16629635
63Tuberculosis_Homo sapiens_hsa051521.16523841
64Staphylococcus aureus infection_Homo sapiens_hsa051501.16469373
65Selenocompound metabolism_Homo sapiens_hsa004501.15023072
66Vitamin B6 metabolism_Homo sapiens_hsa007501.14264887
67African trypanosomiasis_Homo sapiens_hsa051431.13981080
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13547074
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12758957
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12025494
71Bile secretion_Homo sapiens_hsa049761.11191976
72Fanconi anemia pathway_Homo sapiens_hsa034601.10704913
73Influenza A_Homo sapiens_hsa051641.04632611
74Fatty acid metabolism_Homo sapiens_hsa012121.04041683
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03869515
76Lysosome_Homo sapiens_hsa041420.98121295
77Collecting duct acid secretion_Homo sapiens_hsa049660.97870609
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97646296
79One carbon pool by folate_Homo sapiens_hsa006700.97598184
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.97226283
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96081140
82Osteoclast differentiation_Homo sapiens_hsa043800.95755701
83Biosynthesis of amino acids_Homo sapiens_hsa012300.95082271
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93973683
85Sulfur metabolism_Homo sapiens_hsa009200.93434077
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90935985
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90713786
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90582194
89RNA polymerase_Homo sapiens_hsa030200.90385883
90Proteasome_Homo sapiens_hsa030500.90065104
91Basal transcription factors_Homo sapiens_hsa030220.89849086
92Regulation of autophagy_Homo sapiens_hsa041400.88541411
93beta-Alanine metabolism_Homo sapiens_hsa004100.88299459
94Carbon metabolism_Homo sapiens_hsa012000.88081927
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85405393
96Salmonella infection_Homo sapiens_hsa051320.84099180
97Protein export_Homo sapiens_hsa030600.83887728
98TNF signaling pathway_Homo sapiens_hsa046680.80996366
99Fatty acid elongation_Homo sapiens_hsa000620.80207964
100Glutathione metabolism_Homo sapiens_hsa004800.80075166
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78413962
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78369841
103Nitrogen metabolism_Homo sapiens_hsa009100.77636944
104Ether lipid metabolism_Homo sapiens_hsa005650.76762816
105Fat digestion and absorption_Homo sapiens_hsa049750.75775977
106Non-homologous end-joining_Homo sapiens_hsa034500.74969593
107Mismatch repair_Homo sapiens_hsa034300.74301294
108Folate biosynthesis_Homo sapiens_hsa007900.73466951
109Metabolic pathways_Homo sapiens_hsa011000.73360306
110ABC transporters_Homo sapiens_hsa020100.72149254
111Lysine degradation_Homo sapiens_hsa003100.71276488
112PPAR signaling pathway_Homo sapiens_hsa033200.70080829
113Phagosome_Homo sapiens_hsa041450.69674051
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69557208
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68568013
116Phototransduction_Homo sapiens_hsa047440.67498501
117Steroid biosynthesis_Homo sapiens_hsa001000.67181237
118Retinol metabolism_Homo sapiens_hsa008300.65749101
119Taste transduction_Homo sapiens_hsa047420.65727152
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65065458
121Pyrimidine metabolism_Homo sapiens_hsa002400.64382606
122Base excision repair_Homo sapiens_hsa034100.62404673
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62066416
124Purine metabolism_Homo sapiens_hsa002300.61114482
125Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60000178
126Linoleic acid metabolism_Homo sapiens_hsa005910.59664381
127Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56856953
128Antigen processing and presentation_Homo sapiens_hsa046120.55719477
129RNA degradation_Homo sapiens_hsa030180.52442914
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51026632
131RNA transport_Homo sapiens_hsa030130.50931912
132Thyroid hormone synthesis_Homo sapiens_hsa049180.50859820
133Shigellosis_Homo sapiens_hsa051310.50542540
134Sulfur relay system_Homo sapiens_hsa041220.50023223
135Oxidative phosphorylation_Homo sapiens_hsa001900.48157181
136Peroxisome_Homo sapiens_hsa041460.47584749
137Ovarian steroidogenesis_Homo sapiens_hsa049130.47327650
138Toxoplasmosis_Homo sapiens_hsa051450.46891630
139Chemokine signaling pathway_Homo sapiens_hsa040620.46441836
140Nicotine addiction_Homo sapiens_hsa050330.45301500
141Histidine metabolism_Homo sapiens_hsa003400.44313758
142Leukocyte transendothelial migration_Homo sapiens_hsa046700.43753471
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41736455
144DNA replication_Homo sapiens_hsa030300.41488536
145Hepatitis C_Homo sapiens_hsa051600.40742537
146TGF-beta signaling pathway_Homo sapiens_hsa043500.40098949
147Chemical carcinogenesis_Homo sapiens_hsa052040.39387243
148Glycerolipid metabolism_Homo sapiens_hsa005610.38434932
149Hepatitis B_Homo sapiens_hsa051610.37600985
150B cell receptor signaling pathway_Homo sapiens_hsa046620.37363535
151Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34450680
152Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32343395
153Nucleotide excision repair_Homo sapiens_hsa034200.32042365
154Protein digestion and absorption_Homo sapiens_hsa049740.32015947
155p53 signaling pathway_Homo sapiens_hsa041150.31710967
156Calcium signaling pathway_Homo sapiens_hsa040200.31333645
157Arginine and proline metabolism_Homo sapiens_hsa003300.28528193
158Circadian rhythm_Homo sapiens_hsa047100.27862153
159Fatty acid biosynthesis_Homo sapiens_hsa000610.27388301
160Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27335203
161T cell receptor signaling pathway_Homo sapiens_hsa046600.27009140
162Huntingtons disease_Homo sapiens_hsa050160.25988127
163Parkinsons disease_Homo sapiens_hsa050120.24293798
164Fructose and mannose metabolism_Homo sapiens_hsa000510.23996751
165Systemic lupus erythematosus_Homo sapiens_hsa053220.22027333

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