

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | protein localization to kinetochore (GO:0034501) | 5.17983140 |
| 2 | DNA unwinding involved in DNA replication (GO:0006268) | 5.13380042 |
| 3 | DNA replication initiation (GO:0006270) | 5.05207917 |
| 4 | DNA strand elongation involved in DNA replication (GO:0006271) | 5.03205077 |
| 5 | DNA replication checkpoint (GO:0000076) | 4.89875839 |
| 6 | mitotic chromosome condensation (GO:0007076) | 4.87623075 |
| 7 | DNA strand elongation (GO:0022616) | 4.84961840 |
| 8 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.80394963 |
| 9 | kinetochore organization (GO:0051383) | 4.58335266 |
| 10 | mitotic sister chromatid segregation (GO:0000070) | 4.56786954 |
| 11 | mitotic recombination (GO:0006312) | 4.56555931 |
| 12 | protein localization to chromosome, centromeric region (GO:0071459) | 4.53925418 |
| 13 | telomere maintenance via recombination (GO:0000722) | 4.52530802 |
| 14 | chromatin remodeling at centromere (GO:0031055) | 4.51751341 |
| 15 | CENP-A containing nucleosome assembly (GO:0034080) | 4.50861642 |
| 16 | attachment of spindle microtubules to kinetochore (GO:0008608) | 4.44219665 |
| 17 | mitotic metaphase plate congression (GO:0007080) | 4.43337859 |
| 18 | nuclear pore complex assembly (GO:0051292) | 4.42204325 |
| 19 | nuclear pore organization (GO:0006999) | 4.31351483 |
| 20 | sister chromatid segregation (GO:0000819) | 4.29544731 |
| 21 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.20257273 |
| 22 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.20257273 |
| 23 | meiotic chromosome segregation (GO:0045132) | 4.18190517 |
| 24 | DNA replication-independent nucleosome organization (GO:0034724) | 4.15624653 |
| 25 | DNA replication-independent nucleosome assembly (GO:0006336) | 4.15624653 |
| 26 | regulation of DNA endoreduplication (GO:0032875) | 4.06847116 |
| 27 | mitotic nuclear envelope disassembly (GO:0007077) | 4.03270643 |
| 28 | telomere maintenance via telomere lengthening (GO:0010833) | 3.97927332 |
| 29 | mitotic sister chromatid cohesion (GO:0007064) | 3.96533201 |
| 30 | metaphase plate congression (GO:0051310) | 3.95174071 |
| 31 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.94977142 |
| 32 | kinetochore assembly (GO:0051382) | 3.93760197 |
| 33 | protein K6-linked ubiquitination (GO:0085020) | 3.82463329 |
| 34 | histone exchange (GO:0043486) | 3.74532253 |
| 35 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.73865262 |
| 36 | establishment of chromosome localization (GO:0051303) | 3.73186741 |
| 37 | membrane disassembly (GO:0030397) | 3.69554844 |
| 38 | nuclear envelope disassembly (GO:0051081) | 3.69554844 |
| 39 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.66535041 |
| 40 | DNA geometric change (GO:0032392) | 3.61640283 |
| 41 | DNA duplex unwinding (GO:0032508) | 3.60958612 |
| 42 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.60177529 |
| 43 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.59258652 |
| 44 | positive regulation of chromosome segregation (GO:0051984) | 3.58681703 |
| 45 | chromosome segregation (GO:0007059) | 3.48924414 |
| 46 | pore complex assembly (GO:0046931) | 3.48692107 |
| 47 | chromatin assembly or disassembly (GO:0006333) | 3.48652186 |
| 48 | DNA double-strand break processing (GO:0000729) | 3.46722119 |
| 49 | telomere maintenance (GO:0000723) | 3.43369657 |
| 50 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.42798206 |
| 51 | IMP biosynthetic process (GO:0006188) | 3.42224856 |
| 52 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.42118790 |
| 53 | double-strand break repair via homologous recombination (GO:0000724) | 3.42047731 |
| 54 | mismatch repair (GO:0006298) | 3.41943821 |
| 55 | recombinational repair (GO:0000725) | 3.41559137 |
| 56 | synapsis (GO:0007129) | 3.40499114 |
| 57 | protein localization to chromosome (GO:0034502) | 3.40359600 |
| 58 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.40301835 |
| 59 | telomere organization (GO:0032200) | 3.40221856 |
| 60 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.39512349 |
| 61 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.39512349 |
| 62 | centriole replication (GO:0007099) | 3.37992195 |
| 63 | purine nucleobase biosynthetic process (GO:0009113) | 3.37544584 |
| 64 | regulation of sister chromatid cohesion (GO:0007063) | 3.35783014 |
| 65 | replication fork processing (GO:0031297) | 3.33601055 |
| 66 | regulation of spindle organization (GO:0090224) | 3.32281348 |
| 67 | regulation of histone H3-K9 methylation (GO:0051570) | 3.28896658 |
| 68 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.26472380 |
| 69 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.26472380 |
| 70 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.26472380 |
| 71 | dosage compensation (GO:0007549) | 3.25126944 |
| 72 | positive regulation of histone H3-K4 methylation (GO:0051571) | 3.24945037 |
| 73 | non-recombinational repair (GO:0000726) | 3.24132535 |
| 74 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.24132535 |
| 75 | nucleobase biosynthetic process (GO:0046112) | 3.21276535 |
| 76 | DNA topological change (GO:0006265) | 3.20826705 |
| 77 | DNA conformation change (GO:0071103) | 3.20799240 |
| 78 | spindle checkpoint (GO:0031577) | 3.19024058 |
| 79 | regulation of chromosome segregation (GO:0051983) | 3.17868861 |
| 80 | IMP metabolic process (GO:0046040) | 3.16500482 |
| 81 | regulation of centrosome cycle (GO:0046605) | 3.16067241 |
| 82 | microtubule depolymerization (GO:0007019) | 3.14295691 |
| 83 | intra-S DNA damage checkpoint (GO:0031573) | 3.13240609 |
| 84 | ATP-dependent chromatin remodeling (GO:0043044) | 3.11501434 |
| 85 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.10894158 |
| 86 | DNA synthesis involved in DNA repair (GO:0000731) | 3.10693815 |
| 87 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.08780940 |
| 88 | regulation of double-strand break repair (GO:2000779) | 3.07173230 |
| 89 | translesion synthesis (GO:0019985) | 3.06631128 |
| 90 | regulation of centrosome duplication (GO:0010824) | 3.05762027 |
| 91 | somatic recombination of immunoglobulin gene segments (GO:0016447) | 3.05568718 |
| 92 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.04959489 |
| 93 | ribosomal small subunit assembly (GO:0000028) | 3.04593645 |
| 94 | somatic cell DNA recombination (GO:0016444) | 3.04576821 |
| 95 | somatic diversification of immune receptors via germline recombination within a single locus (GO:000 | 3.04576821 |
| 96 | DNA recombination (GO:0006310) | 3.04157080 |
| 97 | establishment of integrated proviral latency (GO:0075713) | 3.02277221 |
| 98 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.02116198 |
| 99 | negative regulation of chromosome segregation (GO:0051985) | 3.02115955 |
| 100 | negative regulation of histone methylation (GO:0031061) | 3.01569312 |
| 101 | DNA replication (GO:0006260) | 3.01404256 |
| 102 | cell cycle G1/S phase transition (GO:0044843) | 3.01102196 |
| 103 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.01102196 |
| 104 | base-excision repair (GO:0006284) | 2.99441573 |
| 105 | spindle assembly checkpoint (GO:0071173) | 2.99200415 |
| 106 | chromosome condensation (GO:0030261) | 2.98726705 |
| 107 | somatic diversification of immune receptors (GO:0002200) | 2.98341325 |
| 108 | double-strand break repair (GO:0006302) | 2.98056187 |
| 109 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 2.96930002 |
| 110 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 2.96930002 |
| 111 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 2.96930002 |
| 112 | negative regulation of sister chromatid segregation (GO:0033046) | 2.96930002 |
| 113 | somatic diversification of immunoglobulins (GO:0016445) | 2.96820505 |
| 114 | regulation of DNA-dependent DNA replication (GO:0090329) | 2.96581659 |
| 115 | DNA strand renaturation (GO:0000733) | 2.96406661 |
| 116 | DNA ligation (GO:0006266) | 2.95987034 |
| 117 | regulation of sister chromatid segregation (GO:0033045) | 2.95897240 |
| 118 | regulation of mitotic sister chromatid separation (GO:0010965) | 2.95897240 |
| 119 | regulation of mitotic sister chromatid segregation (GO:0033047) | 2.95897240 |
| 120 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 2.95344318 |
| 121 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 2.93486611 |
| 122 | mitotic cell cycle (GO:0000278) | 2.93118661 |
| 123 | regulation of centriole replication (GO:0046599) | 2.93053558 |
| 124 | regulation of mitotic spindle organization (GO:0060236) | 2.92582843 |
| 125 | tetrahydrofolate metabolic process (GO:0046653) | 2.92304696 |
| 126 | mitotic spindle checkpoint (GO:0071174) | 2.90653352 |
| 127 | positive regulation of DNA-dependent DNA replication (GO:2000105) | 2.89740687 |
| 128 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 2.89505806 |
| 129 | postreplication repair (GO:0006301) | 2.88915850 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 5.49750981 |
| 2 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 4.77739449 |
| 3 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.90680632 |
| 4 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.52173876 |
| 5 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.59646910 |
| 6 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.56210538 |
| 7 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.53816765 |
| 8 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.51137790 |
| 9 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.48903922 |
| 10 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.47874662 |
| 11 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.36537153 |
| 12 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.26259930 |
| 13 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.19256386 |
| 14 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.15796802 |
| 15 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.13421124 |
| 16 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.08813642 |
| 17 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.06791500 |
| 18 | * MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.01182406 |
| 19 | E2F7_22180533_ChIP-Seq_HELA_Human | 12.1131204 |
| 20 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.97515620 |
| 21 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.89940960 |
| 22 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.87009221 |
| 23 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.86458229 |
| 24 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.85904801 |
| 25 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.84731664 |
| 26 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.81615233 |
| 27 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.80024253 |
| 28 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.75652666 |
| 29 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.74851915 |
| 30 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.70068455 |
| 31 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.68410221 |
| 32 | MYC_22102868_ChIP-Seq_BL_Human | 1.64651081 |
| 33 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.61092767 |
| 34 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.59911605 |
| 35 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.59620789 |
| 36 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.58163024 |
| 37 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.57255097 |
| 38 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.55372829 |
| 39 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.52481814 |
| 40 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.52453399 |
| 41 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.52156239 |
| 42 | * ELK1_19687146_ChIP-ChIP_HELA_Human | 1.52074359 |
| 43 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.51517523 |
| 44 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.51413041 |
| 45 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.44267050 |
| 46 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.43393551 |
| 47 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.41302092 |
| 48 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.37400539 |
| 49 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.35781761 |
| 50 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.34153776 |
| 51 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.33216851 |
| 52 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.32845038 |
| 53 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.30691882 |
| 54 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.27930093 |
| 55 | EWS_26573619_Chip-Seq_HEK293_Human | 1.27849804 |
| 56 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.26210769 |
| 57 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.20965425 |
| 58 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.19564205 |
| 59 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.18690006 |
| 60 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.17893147 |
| 61 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.17554300 |
| 62 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.16990090 |
| 63 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.15140235 |
| 64 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.14903890 |
| 65 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.14729022 |
| 66 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.14627789 |
| 67 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.10380522 |
| 68 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.10154430 |
| 69 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.08976381 |
| 70 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.07036003 |
| 71 | VDR_22108803_ChIP-Seq_LS180_Human | 1.06292946 |
| 72 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.05330347 |
| 73 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.02479087 |
| 74 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.01656142 |
| 75 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.01193583 |
| 76 | FUS_26573619_Chip-Seq_HEK293_Human | 1.00968160 |
| 77 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.00537467 |
| 78 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.98815616 |
| 79 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.95062435 |
| 80 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.94988290 |
| 81 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.94166065 |
| 82 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.94026234 |
| 83 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.92291267 |
| 84 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.90992335 |
| 85 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.88333799 |
| 86 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.88101770 |
| 87 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.88101770 |
| 88 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.88101770 |
| 89 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.87938368 |
| 90 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.87708159 |
| 91 | * GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.87336091 |
| 92 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.86064497 |
| 93 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.83884171 |
| 94 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.82677301 |
| 95 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.80047485 |
| 96 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.79671647 |
| 97 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.78949431 |
| 98 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.78827238 |
| 99 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.78821339 |
| 100 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.78763624 |
| 101 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.77658019 |
| 102 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.77135607 |
| 103 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.76941894 |
| 104 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.76518303 |
| 105 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.76176734 |
| 106 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.75676791 |
| 107 | * MYB_26560356_Chip-Seq_TH1_Human | 0.73249107 |
| 108 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.71401770 |
| 109 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.70707669 |
| 110 | * BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.70639471 |
| 111 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.68363107 |
| 112 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.60734533 |
| 113 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.59993274 |
| 114 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.59790274 |
| 115 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.58758074 |
| 116 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.58742692 |
| 117 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.57652835 |
| 118 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.56947929 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0010094_abnormal_chromosome_stability | 5.44394630 |
| 2 | MP0003693_abnormal_embryo_hatching | 4.66931985 |
| 3 | MP0008057_abnormal_DNA_replication | 4.66454539 |
| 4 | MP0003111_abnormal_nucleus_morphology | 4.56889863 |
| 5 | MP0003077_abnormal_cell_cycle | 4.03202378 |
| 6 | MP0004957_abnormal_blastocyst_morpholog | 3.97886342 |
| 7 | MP0008058_abnormal_DNA_repair | 3.32162909 |
| 8 | MP0008877_abnormal_DNA_methylation | 2.84277074 |
| 9 | MP0008007_abnormal_cellular_replicative | 2.72681597 |
| 10 | MP0009697_abnormal_copulation | 2.53572296 |
| 11 | MP0008932_abnormal_embryonic_tissue | 2.52154585 |
| 12 | MP0002396_abnormal_hematopoietic_system | 2.46580088 |
| 13 | MP0000350_abnormal_cell_proliferation | 2.27943294 |
| 14 | MP0001730_embryonic_growth_arrest | 2.05895388 |
| 15 | MP0010307_abnormal_tumor_latency | 2.03969671 |
| 16 | MP0003786_premature_aging | 2.02257000 |
| 17 | MP0004147_increased_porphyrin_level | 2.01175969 |
| 18 | MP0003718_maternal_effect | 1.92430215 |
| 19 | MP0003121_genomic_imprinting | 1.92005049 |
| 20 | MP0003123_paternal_imprinting | 1.90704793 |
| 21 | MP0010352_gastrointestinal_tract_polyps | 1.90529043 |
| 22 | MP0000372_irregular_coat_pigmentation | 1.87430846 |
| 23 | MP0000490_abnormal_crypts_of | 1.85149041 |
| 24 | MP0005380_embryogenesis_phenotype | 1.74354172 |
| 25 | MP0001672_abnormal_embryogenesis/_devel | 1.74354172 |
| 26 | MP0002234_abnormal_pharynx_morphology | 1.72939831 |
| 27 | MP0002938_white_spotting | 1.70724473 |
| 28 | MP0001697_abnormal_embryo_size | 1.65535510 |
| 29 | MP0004808_abnormal_hematopoietic_stem | 1.62435295 |
| 30 | MP0006292_abnormal_olfactory_placode | 1.59578557 |
| 31 | MP0002085_abnormal_embryonic_tissue | 1.55516205 |
| 32 | MP0003890_abnormal_embryonic-extraembry | 1.53893109 |
| 33 | MP0003984_embryonic_growth_retardation | 1.50883798 |
| 34 | MP0002019_abnormal_tumor_incidence | 1.49011843 |
| 35 | MP0003787_abnormal_imprinting | 1.48424736 |
| 36 | MP0000313_abnormal_cell_death | 1.48398025 |
| 37 | MP0002088_abnormal_embryonic_growth/wei | 1.46878740 |
| 38 | MP0003763_abnormal_thymus_physiology | 1.46215891 |
| 39 | MP0002163_abnormal_gland_morphology | 1.46126574 |
| 40 | MP0002084_abnormal_developmental_patter | 1.43528390 |
| 41 | MP0003806_abnormal_nucleotide_metabolis | 1.39255403 |
| 42 | MP0002080_prenatal_lethality | 1.38952288 |
| 43 | MP0002086_abnormal_extraembryonic_tissu | 1.36776386 |
| 44 | MP0002210_abnormal_sex_determination | 1.35988953 |
| 45 | MP0004197_abnormal_fetal_growth/weight/ | 1.32189224 |
| 46 | MP0000703_abnormal_thymus_morphology | 1.27894849 |
| 47 | MP0001545_abnormal_hematopoietic_system | 1.27350755 |
| 48 | MP0005397_hematopoietic_system_phenotyp | 1.27350755 |
| 49 | MP0002398_abnormal_bone_marrow | 1.25621797 |
| 50 | MP0001119_abnormal_female_reproductive | 1.17208312 |
| 51 | MP0001929_abnormal_gametogenesis | 1.14607803 |
| 52 | MP0002653_abnormal_ependyma_morphology | 1.14541032 |
| 53 | MP0005171_absent_coat_pigmentation | 1.13353566 |
| 54 | MP0001145_abnormal_male_reproductive | 1.13234888 |
| 55 | MP0003315_abnormal_perineum_morphology | 1.12976327 |
| 56 | MP0005076_abnormal_cell_differentiation | 1.12685373 |
| 57 | MP0000689_abnormal_spleen_morphology | 1.12259514 |
| 58 | MP0000653_abnormal_sex_gland | 1.10349214 |
| 59 | MP0002722_abnormal_immune_system | 1.10043645 |
| 60 | MP0006072_abnormal_retinal_apoptosis | 1.09696829 |
| 61 | MP0003567_abnormal_fetal_cardiomyocyte | 1.09535248 |
| 62 | MP0003937_abnormal_limbs/digits/tail_de | 1.08937683 |
| 63 | MP0001293_anophthalmia | 1.07564194 |
| 64 | MP0002009_preneoplasia | 1.06301212 |
| 65 | MP0006035_abnormal_mitochondrial_morpho | 0.99975341 |
| 66 | MP0000427_abnormal_hair_cycle | 0.93762979 |
| 67 | MP0002006_tumorigenesis | 0.93181089 |
| 68 | MP0009278_abnormal_bone_marrow | 0.89971295 |
| 69 | MP0001346_abnormal_lacrimal_gland | 0.89863118 |
| 70 | MP0002429_abnormal_blood_cell | 0.88626038 |
| 71 | MP0003698_abnormal_male_reproductive | 0.88285210 |
| 72 | MP0009333_abnormal_splenocyte_physiolog | 0.87769359 |
| 73 | MP0005645_abnormal_hypothalamus_physiol | 0.87758029 |
| 74 | MP0003699_abnormal_female_reproductive | 0.87638009 |
| 75 | MP0000358_abnormal_cell_content/ | 0.84448693 |
| 76 | MP0002877_abnormal_melanocyte_morpholog | 0.83338321 |
| 77 | MP0006036_abnormal_mitochondrial_physio | 0.82666559 |
| 78 | MP0003136_yellow_coat_color | 0.82664421 |
| 79 | MP0000631_abnormal_neuroendocrine_gland | 0.82401622 |
| 80 | MP0006054_spinal_hemorrhage | 0.82010134 |
| 81 | MP0001915_intracranial_hemorrhage | 0.81692076 |
| 82 | MP0000716_abnormal_immune_system | 0.81593579 |
| 83 | MP0005075_abnormal_melanosome_morpholog | 0.80495046 |
| 84 | MP0005408_hypopigmentation | 0.79092171 |
| 85 | MP0002102_abnormal_ear_morphology | 0.78384876 |
| 86 | MP0001800_abnormal_humoral_immune | 0.77736621 |
| 87 | MP0008995_early_reproductive_senescence | 0.77261868 |
| 88 | MP0005379_endocrine/exocrine_gland_phen | 0.76664743 |
| 89 | MP0005389_reproductive_system_phenotype | 0.76430638 |
| 90 | MP0009703_decreased_birth_body | 0.75390025 |
| 91 | MP0001286_abnormal_eye_development | 0.75063934 |
| 92 | MP0004264_abnormal_extraembryonic_tissu | 0.73670806 |
| 93 | MP0002095_abnormal_skin_pigmentation | 0.73511397 |
| 94 | MP0000647_abnormal_sebaceous_gland | 0.73115302 |
| 95 | MP0002166_altered_tumor_susceptibility | 0.72607917 |
| 96 | MP0002160_abnormal_reproductive_system | 0.71989540 |
| 97 | MP0005384_cellular_phenotype | 0.71255236 |
| 98 | MP0005671_abnormal_response_to | 0.69675354 |
| 99 | MP0002751_abnormal_autonomic_nervous | 0.68808818 |
| 100 | MP0002111_abnormal_tail_morphology | 0.68736890 |
| 101 | MP0002075_abnormal_coat/hair_pigmentati | 0.68525160 |
| 102 | MP0000015_abnormal_ear_pigmentation | 0.67831705 |
| 103 | MP0005621_abnormal_cell_physiology | 0.67775029 |
| 104 | MP0001529_abnormal_vocalization | 0.66878101 |
| 105 | MP0002420_abnormal_adaptive_immunity | 0.65009394 |
| 106 | MP0003119_abnormal_digestive_system | 0.64277982 |
| 107 | MP0010030_abnormal_orbit_morphology | 0.64015698 |
| 108 | MP0009672_abnormal_birth_weight | 0.63924411 |
| 109 | MP0003950_abnormal_plasma_membrane | 0.63786281 |
| 110 | MP0000477_abnormal_intestine_morphology | 0.63180870 |
| 111 | MP0001819_abnormal_immune_cell | 0.62797757 |
| 112 | MP0000432_abnormal_head_morphology | 0.62773919 |
| 113 | MP0001661_extended_life_span | 0.62673244 |
| 114 | MP0000569_abnormal_digit_pigmentation | 0.62186639 |
| 115 | MP0001919_abnormal_reproductive_system | 0.62108719 |
| 116 | MP0001873_stomach_inflammation | 0.61401433 |
| 117 | MP0009053_abnormal_anal_canal | 0.60870909 |
| 118 | MP0005253_abnormal_eye_physiology | 0.60659067 |
| 119 | MP0001186_pigmentation_phenotype | 0.60243146 |
| 120 | MP0008789_abnormal_olfactory_epithelium | 0.58319653 |
| 121 | MP0002452_abnormal_antigen_presenting | 0.58107979 |
| 122 | MP0002697_abnormal_eye_size | 0.57707707 |
| 123 | MP0005266_abnormal_metabolism | 0.56577808 |
| 124 | MP0005174_abnormal_tail_pigmentation | 0.55783204 |
| 125 | MP0003656_abnormal_erythrocyte_physiolo | 0.55578329 |
| 126 | MP0003936_abnormal_reproductive_system | 0.55203881 |
| 127 | MP0002405_respiratory_system_inflammati | 0.54793377 |
| 128 | MP0002092_abnormal_eye_morphology | 0.54229229 |
| 129 | MP0000465_gastrointestinal_hemorrhage | 0.53583442 |
| 130 | MP0005395_other_phenotype | 0.53260015 |
| 131 | MP0002161_abnormal_fertility/fecundity | 0.53116091 |
| 132 | MP0003943_abnormal_hepatobiliary_system | 0.52983784 |
| 133 | MP0005187_abnormal_penis_morphology | 0.52592481 |
| 134 | MP0001881_abnormal_mammary_gland | 0.52333536 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Chromsome breakage (HP:0040012) | 6.01365027 |
| 2 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 5.68679550 |
| 3 | Birth length less than 3rd percentile (HP:0003561) | 5.04600107 |
| 4 | Abnormality of chromosome stability (HP:0003220) | 4.21711505 |
| 5 | Breast hypoplasia (HP:0003187) | 3.66676802 |
| 6 | Meckel diverticulum (HP:0002245) | 3.64706195 |
| 7 | Abnormality of the preputium (HP:0100587) | 3.57472366 |
| 8 | Reticulocytopenia (HP:0001896) | 3.57197258 |
| 9 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.55808598 |
| 10 | Abnormality of the ileum (HP:0001549) | 3.51903646 |
| 11 | Patellar aplasia (HP:0006443) | 3.35434863 |
| 12 | Ectopic kidney (HP:0000086) | 3.25555589 |
| 13 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.19858338 |
| 14 | Abnormality of the labia minora (HP:0012880) | 3.17467848 |
| 15 | Medulloblastoma (HP:0002885) | 3.17113004 |
| 16 | Myelodysplasia (HP:0002863) | 3.13048417 |
| 17 | Impulsivity (HP:0100710) | 3.09747462 |
| 18 | Small intestinal stenosis (HP:0012848) | 3.04153503 |
| 19 | Duodenal stenosis (HP:0100867) | 3.04153503 |
| 20 | Absent radius (HP:0003974) | 3.01662155 |
| 21 | Volvulus (HP:0002580) | 2.96279987 |
| 22 | Ependymoma (HP:0002888) | 2.95686938 |
| 23 | Duplicated collecting system (HP:0000081) | 2.93915165 |
| 24 | Rhabdomyosarcoma (HP:0002859) | 2.83400344 |
| 25 | Absent forearm bone (HP:0003953) | 2.80944015 |
| 26 | Aplasia involving forearm bones (HP:0009822) | 2.80944015 |
| 27 | Agnosia (HP:0010524) | 2.76209468 |
| 28 | Clubbing of toes (HP:0100760) | 2.73468970 |
| 29 | Bone marrow hypocellularity (HP:0005528) | 2.73405420 |
| 30 | Absent thumb (HP:0009777) | 2.67987832 |
| 31 | Supernumerary spleens (HP:0009799) | 2.63793340 |
| 32 | Abnormality of the renal collecting system (HP:0004742) | 2.63782547 |
| 33 | Sloping forehead (HP:0000340) | 2.62936638 |
| 34 | Abnormality of the fingertips (HP:0001211) | 2.61129403 |
| 35 | Colon cancer (HP:0003003) | 2.59770595 |
| 36 | Aplastic anemia (HP:0001915) | 2.57566659 |
| 37 | Abnormality of the carotid arteries (HP:0005344) | 2.55316253 |
| 38 | Abnormal lung lobation (HP:0002101) | 2.52265586 |
| 39 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.51484184 |
| 40 | Abnormality of the duodenum (HP:0002246) | 2.46485697 |
| 41 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.45006622 |
| 42 | Oral leukoplakia (HP:0002745) | 2.41933309 |
| 43 | Abnormality of DNA repair (HP:0003254) | 2.41639158 |
| 44 | Abnormal number of erythroid precursors (HP:0012131) | 2.41014275 |
| 45 | Rib fusion (HP:0000902) | 2.33522360 |
| 46 | Cafe-au-lait spot (HP:0000957) | 2.33489695 |
| 47 | Degeneration of anterior horn cells (HP:0002398) | 2.31564642 |
| 48 | Abnormality of the anterior horn cell (HP:0006802) | 2.31564642 |
| 49 | 11 pairs of ribs (HP:0000878) | 2.31106175 |
| 50 | Embryonal renal neoplasm (HP:0011794) | 2.30919924 |
| 51 | Short thumb (HP:0009778) | 2.28489372 |
| 52 | Selective tooth agenesis (HP:0001592) | 2.27471484 |
| 53 | Abnormality of cochlea (HP:0000375) | 2.25483691 |
| 54 | Abnormality of the pons (HP:0007361) | 2.24088182 |
| 55 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.22758532 |
| 56 | Hypoplasia of the pons (HP:0012110) | 2.21677708 |
| 57 | Facial hemangioma (HP:0000329) | 2.21196129 |
| 58 | Abnormality of chromosome segregation (HP:0002916) | 2.19259089 |
| 59 | Increased nuchal translucency (HP:0010880) | 2.19213674 |
| 60 | Pancytopenia (HP:0001876) | 2.18985821 |
| 61 | Premature graying of hair (HP:0002216) | 2.17569506 |
| 62 | Arteriovenous malformation (HP:0100026) | 2.15176486 |
| 63 | Horseshoe kidney (HP:0000085) | 2.15064757 |
| 64 | Triphalangeal thumb (HP:0001199) | 2.13071053 |
| 65 | Hyperalaninemia (HP:0003348) | 2.11991095 |
| 66 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.11991095 |
| 67 | Abnormality of alanine metabolism (HP:0010916) | 2.11991095 |
| 68 | Lymphoma (HP:0002665) | 2.10479513 |
| 69 | Basal cell carcinoma (HP:0002671) | 2.09696523 |
| 70 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.09627126 |
| 71 | Tracheoesophageal fistula (HP:0002575) | 2.09373284 |
| 72 | Acute necrotizing encephalopathy (HP:0006965) | 2.07991541 |
| 73 | Increased hepatocellular lipid droplets (HP:0006565) | 2.06835264 |
| 74 | Cellular immunodeficiency (HP:0005374) | 2.06225706 |
| 75 | Increased CSF lactate (HP:0002490) | 2.04553857 |
| 76 | Prominent nose (HP:0000448) | 2.04009832 |
| 77 | Combined immunodeficiency (HP:0005387) | 2.03119494 |
| 78 | Shawl scrotum (HP:0000049) | 2.02871275 |
| 79 | High pitched voice (HP:0001620) | 2.02768116 |
| 80 | Neoplasm of striated muscle (HP:0009728) | 2.02155361 |
| 81 | Neoplasm of the oral cavity (HP:0100649) | 2.02085381 |
| 82 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.00983264 |
| 83 | Abnormal number of incisors (HP:0011064) | 1.97450585 |
| 84 | Carpal bone hypoplasia (HP:0001498) | 1.97393344 |
| 85 | Amaurosis fugax (HP:0100576) | 1.96661026 |
| 86 | Acute lymphatic leukemia (HP:0006721) | 1.94808725 |
| 87 | Pallor (HP:0000980) | 1.94332867 |
| 88 | Acute myeloid leukemia (HP:0004808) | 1.94284693 |
| 89 | Asplenia (HP:0001746) | 1.94208723 |
| 90 | Acute encephalopathy (HP:0006846) | 1.93616676 |
| 91 | Lipid accumulation in hepatocytes (HP:0006561) | 1.93132708 |
| 92 | Atresia of the external auditory canal (HP:0000413) | 1.91624217 |
| 93 | Deviation of the thumb (HP:0009603) | 1.87418912 |
| 94 | Neoplasm of the colon (HP:0100273) | 1.86103776 |
| 95 | Increased serum lactate (HP:0002151) | 1.85823599 |
| 96 | Pancreatic cysts (HP:0001737) | 1.85568930 |
| 97 | Abnormality of the astrocytes (HP:0100707) | 1.84533509 |
| 98 | Astrocytoma (HP:0009592) | 1.84533509 |
| 99 | Macrocytic anemia (HP:0001972) | 1.83735570 |
| 100 | B lymphocytopenia (HP:0010976) | 1.83358881 |
| 101 | Proximal placement of thumb (HP:0009623) | 1.82346956 |
| 102 | Neoplasm of the pancreas (HP:0002894) | 1.81902629 |
| 103 | Small hand (HP:0200055) | 1.81806633 |
| 104 | Deep philtrum (HP:0002002) | 1.81681172 |
| 105 | Abdominal situs inversus (HP:0003363) | 1.80403489 |
| 106 | Abnormality of abdominal situs (HP:0011620) | 1.80403489 |
| 107 | Pancreatic fibrosis (HP:0100732) | 1.80119160 |
| 108 | Sandal gap (HP:0001852) | 1.79607465 |
| 109 | Mitochondrial inheritance (HP:0001427) | 1.79535013 |
| 110 | Choanal atresia (HP:0000453) | 1.79226445 |
| 111 | Squamous cell carcinoma (HP:0002860) | 1.79087392 |
| 112 | Missing ribs (HP:0000921) | 1.78365304 |
| 113 | Oligodactyly (hands) (HP:0001180) | 1.77500247 |
| 114 | Glioma (HP:0009733) | 1.77175491 |
| 115 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.77118762 |
| 116 | Poikiloderma (HP:0001029) | 1.76865693 |
| 117 | Cortical dysplasia (HP:0002539) | 1.76822651 |
| 118 | Leukopenia (HP:0001882) | 1.76028808 |
| 119 | Duplication of thumb phalanx (HP:0009942) | 1.75317835 |
| 120 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.75045181 |
| 121 | Severe combined immunodeficiency (HP:0004430) | 1.74158761 |
| 122 | IgM deficiency (HP:0002850) | 1.73837294 |
| 123 | Morphological abnormality of the inner ear (HP:0011390) | 1.72903880 |
| 124 | Progressive macrocephaly (HP:0004481) | 1.72655659 |
| 125 | Abnormality of midbrain morphology (HP:0002418) | 1.72320323 |
| 126 | Molar tooth sign on MRI (HP:0002419) | 1.72320323 |
| 127 | Neoplasm of the adrenal cortex (HP:0100641) | 1.72251811 |
| 128 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 1.69829114 |
| 129 | Hypochromic microcytic anemia (HP:0004840) | 1.69218020 |
| 130 | Oligohydramnios (HP:0001562) | 1.68793628 |
| 131 | Long eyelashes (HP:0000527) | 1.68753948 |
| 132 | Abnormality of B cell number (HP:0010975) | 1.67697127 |
| 133 | Ureteral duplication (HP:0000073) | 1.67546929 |
| 134 | T lymphocytopenia (HP:0005403) | 1.66319873 |
| 135 | Cerebral edema (HP:0002181) | 1.66227633 |
| 136 | Pulmonary fibrosis (HP:0002206) | 1.65259219 |
| 137 | Intestinal fistula (HP:0100819) | 1.65195863 |
| 138 | Microvesicular hepatic steatosis (HP:0001414) | 1.59873202 |
| 139 | Astigmatism (HP:0000483) | 1.58087971 |
| 140 | Hepatic necrosis (HP:0002605) | 1.55702556 |
| 141 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.53819089 |
| 142 | External ear malformation (HP:0008572) | 1.53307799 |
| 143 | Embryonal neoplasm (HP:0002898) | 1.52691238 |
| 144 | Abnormality of homocysteine metabolism (HP:0010919) | 1.52359635 |
| 145 | Homocystinuria (HP:0002156) | 1.52359635 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDC7 | 5.44749364 |
| 2 | WEE1 | 3.72018230 |
| 3 | NEK2 | 3.05482358 |
| 4 | TTK | 2.92830025 |
| 5 | BUB1 | 2.79040517 |
| 6 | CDK12 | 2.78131866 |
| 7 | SRPK1 | 2.62990213 |
| 8 | PLK4 | 2.49735475 |
| 9 | VRK2 | 2.48294988 |
| 10 | MKNK1 | 2.24242218 |
| 11 | BRSK2 | 2.16804233 |
| 12 | PLK1 | 2.15688227 |
| 13 | EEF2K | 2.07247828 |
| 14 | MST4 | 2.07177545 |
| 15 | ATR | 2.06709789 |
| 16 | ACVR1B | 2.04703349 |
| 17 | NUAK1 | 2.03246347 |
| 18 | CHEK2 | 2.02886959 |
| 19 | TLK1 | 1.96601279 |
| 20 | VRK1 | 1.93376891 |
| 21 | MKNK2 | 1.91402761 |
| 22 | EIF2AK1 | 1.86253320 |
| 23 | AURKB | 1.84725911 |
| 24 | STK4 | 1.80518551 |
| 25 | CDK7 | 1.80433952 |
| 26 | STK10 | 1.80347963 |
| 27 | NEK1 | 1.75805592 |
| 28 | RPS6KB2 | 1.73783620 |
| 29 | PLK3 | 1.67138733 |
| 30 | PASK | 1.63565467 |
| 31 | TAF1 | 1.63322118 |
| 32 | ZAK | 1.61383247 |
| 33 | BMPR1B | 1.57649135 |
| 34 | CDK4 | 1.50465410 |
| 35 | CHEK1 | 1.49052884 |
| 36 | MAP3K8 | 1.41228961 |
| 37 | TSSK6 | 1.35139366 |
| 38 | CLK1 | 1.34223656 |
| 39 | MELK | 1.30460534 |
| 40 | PIM1 | 1.29759405 |
| 41 | ATM | 1.28253160 |
| 42 | BRD4 | 1.27149115 |
| 43 | NME2 | 1.27098573 |
| 44 | STK16 | 1.22274230 |
| 45 | BRSK1 | 1.21741413 |
| 46 | CDK8 | 1.18533209 |
| 47 | CCNB1 | 1.13747253 |
| 48 | EIF2AK3 | 1.08717630 |
| 49 | AURKA | 1.07868811 |
| 50 | CDK2 | 1.01620645 |
| 51 | TESK2 | 1.01349134 |
| 52 | FRK | 1.01178778 |
| 53 | CDK6 | 0.98515326 |
| 54 | MAP4K1 | 0.97367317 |
| 55 | TRIM28 | 0.96489984 |
| 56 | RPS6KA4 | 0.94542325 |
| 57 | DYRK3 | 0.91835289 |
| 58 | MAP3K10 | 0.84500920 |
| 59 | STK3 | 0.83750375 |
| 60 | MAP3K6 | 0.83539425 |
| 61 | CDK1 | 0.83231512 |
| 62 | TGFBR1 | 0.81355701 |
| 63 | EIF2AK2 | 0.78483212 |
| 64 | TRPM7 | 0.71355005 |
| 65 | MAP4K2 | 0.67924510 |
| 66 | SCYL2 | 0.67765964 |
| 67 | BCKDK | 0.67045902 |
| 68 | PLK2 | 0.65055588 |
| 69 | MAPKAPK5 | 0.64605332 |
| 70 | WNK4 | 0.64454185 |
| 71 | PBK | 0.62131759 |
| 72 | NME1 | 0.61467519 |
| 73 | YES1 | 0.60262529 |
| 74 | EPHA2 | 0.59538362 |
| 75 | GRK6 | 0.59515952 |
| 76 | BRAF | 0.58114256 |
| 77 | CDK9 | 0.56874834 |
| 78 | CSNK2A1 | 0.56547210 |
| 79 | TEC | 0.55465092 |
| 80 | CSF1R | 0.55330943 |
| 81 | RPS6KA5 | 0.54281152 |
| 82 | PAK4 | 0.54204916 |
| 83 | CSNK2A2 | 0.53447985 |
| 84 | STK39 | 0.53243832 |
| 85 | FLT3 | 0.52901422 |
| 86 | WNK3 | 0.51138703 |
| 87 | ALK | 0.49880307 |
| 88 | CDK3 | 0.49444580 |
| 89 | JAK3 | 0.47611816 |
| 90 | CSNK1D | 0.47376163 |
| 91 | BTK | 0.44766188 |
| 92 | MAPK14 | 0.43628398 |
| 93 | PRKDC | 0.43218666 |
| 94 | CAMK1D | 0.43069498 |
| 95 | TXK | 0.40738791 |
| 96 | CSNK1G3 | 0.40533198 |
| 97 | IRAK4 | 0.40441412 |
| 98 | AKT1 | 0.39544056 |
| 99 | CAMKK2 | 0.39494694 |
| 100 | LATS1 | 0.39217207 |
| 101 | CSNK1G1 | 0.38435254 |
| 102 | MAPK13 | 0.38132341 |
| 103 | CHUK | 0.37649572 |
| 104 | TAOK3 | 0.37285203 |
| 105 | STK38L | 0.35024896 |
| 106 | RPS6KB1 | 0.34142346 |
| 107 | MAPK11 | 0.32751960 |
| 108 | TNIK | 0.32038245 |
| 109 | ERBB4 | 0.31963110 |
| 110 | OXSR1 | 0.31812815 |
| 111 | LRRK2 | 0.31434273 |
| 112 | MTOR | 0.30950356 |
| 113 | CSNK1A1L | 0.29262455 |
| 114 | ADRBK2 | 0.29215588 |
| 115 | MAPK1 | 0.28617560 |
| 116 | PAK1 | 0.28070377 |
| 117 | STK24 | 0.27783318 |
| 118 | AKT2 | 0.27225616 |
| 119 | PNCK | 0.27103539 |
| 120 | INSRR | 0.27017393 |
| 121 | GSK3B | 0.25097852 |
| 122 | PDK2 | 0.24185204 |
| 123 | ERBB3 | 0.24065494 |
| 124 | LYN | 0.24005596 |
| 125 | RAF1 | 0.23977975 |
| 126 | BCR | 0.22952322 |
| 127 | PRKCI | 0.22946204 |
| 128 | AKT3 | 0.22555746 |
| 129 | CSNK1E | 0.22186175 |
| 130 | LCK | 0.21507744 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 5.41854811 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 4.70116904 |
| 3 | Homologous recombination_Homo sapiens_hsa03440 | 3.70574201 |
| 4 | Base excision repair_Homo sapiens_hsa03410 | 3.44498754 |
| 5 | Cell cycle_Homo sapiens_hsa04110 | 3.32364974 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.15033654 |
| 7 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 3.07566377 |
| 8 | Nucleotide excision repair_Homo sapiens_hsa03420 | 3.05770161 |
| 9 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.97548541 |
| 10 | Spliceosome_Homo sapiens_hsa03040 | 2.95968216 |
| 11 | RNA transport_Homo sapiens_hsa03013 | 2.83467763 |
| 12 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.77558396 |
| 13 | RNA polymerase_Homo sapiens_hsa03020 | 2.40806032 |
| 14 | RNA degradation_Homo sapiens_hsa03018 | 2.39420720 |
| 15 | Ribosome_Homo sapiens_hsa03010 | 2.23270425 |
| 16 | Basal transcription factors_Homo sapiens_hsa03022 | 2.13090752 |
| 17 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.06218724 |
| 18 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.97043030 |
| 19 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.84623928 |
| 20 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.75739440 |
| 21 | Proteasome_Homo sapiens_hsa03050 | 1.70242023 |
| 22 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.60855687 |
| 23 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.24851723 |
| 24 | Parkinsons disease_Homo sapiens_hsa05012 | 1.22881614 |
| 25 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.15224536 |
| 26 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.14391537 |
| 27 | Purine metabolism_Homo sapiens_hsa00230 | 1.11943197 |
| 28 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.09508707 |
| 29 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.08040927 |
| 30 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.06439185 |
| 31 | Huntingtons disease_Homo sapiens_hsa05016 | 1.05728848 |
| 32 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.04105836 |
| 33 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.00863741 |
| 34 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.97383720 |
| 35 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.95519061 |
| 36 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.90626931 |
| 37 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.90160866 |
| 38 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.89827735 |
| 39 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.89221186 |
| 40 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.87893140 |
| 41 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.85210094 |
| 42 | HTLV-I infection_Homo sapiens_hsa05166 | 0.84956405 |
| 43 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.83827214 |
| 44 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.81595884 |
| 45 | Sulfur relay system_Homo sapiens_hsa04122 | 0.81179436 |
| 46 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.77692193 |
| 47 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.75751946 |
| 48 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.65607710 |
| 49 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.64017211 |
| 50 | Thyroid cancer_Homo sapiens_hsa05216 | 0.63181566 |
| 51 | Alcoholism_Homo sapiens_hsa05034 | 0.62122471 |
| 52 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.61396537 |
| 53 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.58755046 |
| 54 | Alzheimers disease_Homo sapiens_hsa05010 | 0.57305434 |
| 55 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.57049656 |
| 56 | Colorectal cancer_Homo sapiens_hsa05210 | 0.54934322 |
| 57 | Measles_Homo sapiens_hsa05162 | 0.53969998 |
| 58 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.53525980 |
| 59 | Lysine degradation_Homo sapiens_hsa00310 | 0.52052758 |
| 60 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.52019305 |
| 61 | Hepatitis B_Homo sapiens_hsa05161 | 0.51971186 |
| 62 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.49949172 |
| 63 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.49619399 |
| 64 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.49587237 |
| 65 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.49334323 |
| 66 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.48592783 |
| 67 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.47996263 |
| 68 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.47417593 |
| 69 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.46148073 |
| 70 | Apoptosis_Homo sapiens_hsa04210 | 0.45963305 |
| 71 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.43059811 |
| 72 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.42665611 |
| 73 | Prostate cancer_Homo sapiens_hsa05215 | 0.42419181 |
| 74 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.42341536 |
| 75 | Carbon metabolism_Homo sapiens_hsa01200 | 0.41892250 |
| 76 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.40932832 |
| 77 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.40734138 |
| 78 | Metabolic pathways_Homo sapiens_hsa01100 | 0.39983900 |
| 79 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.36239327 |
| 80 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.35934933 |
| 81 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.35277620 |
| 82 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.33737520 |
| 83 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.33261250 |
| 84 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.33157601 |
| 85 | Pathways in cancer_Homo sapiens_hsa05200 | 0.32880418 |
| 86 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.32285945 |
| 87 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.32179129 |
| 88 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.31494425 |
| 89 | Phototransduction_Homo sapiens_hsa04744 | 0.31449304 |
| 90 | Shigellosis_Homo sapiens_hsa05131 | 0.31188700 |
| 91 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.30911663 |
| 92 | Viral myocarditis_Homo sapiens_hsa05416 | 0.30188587 |
| 93 | Adherens junction_Homo sapiens_hsa04520 | 0.30125003 |
| 94 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.29357097 |
| 95 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.29311713 |
| 96 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.29217954 |
| 97 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.28321229 |
| 98 | Influenza A_Homo sapiens_hsa05164 | 0.27885147 |
| 99 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.26529089 |
| 100 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.26067451 |
| 101 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.25307775 |
| 102 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.24653567 |
| 103 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.24480999 |
| 104 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.24203000 |
| 105 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.23703944 |
| 106 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.23598572 |
| 107 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.23078000 |
| 108 | Legionellosis_Homo sapiens_hsa05134 | 0.22699694 |
| 109 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.22315293 |
| 110 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.22264584 |
| 111 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.21878766 |
| 112 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.21878580 |
| 113 | Olfactory transduction_Homo sapiens_hsa04740 | 0.21638797 |
| 114 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.21628130 |
| 115 | Bladder cancer_Homo sapiens_hsa05219 | 0.20528348 |
| 116 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.19042012 |
| 117 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.17546935 |
| 118 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.17121486 |
| 119 | Leishmaniasis_Homo sapiens_hsa05140 | 0.16387299 |
| 120 | Allograft rejection_Homo sapiens_hsa05330 | 0.16235845 |
| 121 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.15440779 |
| 122 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.14899393 |
| 123 | Protein export_Homo sapiens_hsa03060 | 0.14678731 |
| 124 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.14177674 |
| 125 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.13968963 |
| 126 | Melanoma_Homo sapiens_hsa05218 | 0.13853957 |
| 127 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.13833013 |
| 128 | Asthma_Homo sapiens_hsa05310 | 0.13492538 |
| 129 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.13081632 |
| 130 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.11139213 |
| 131 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.11092385 |
| 132 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.09495075 |
| 133 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.09007586 |
| 134 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.07628279 |
| 135 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.06704933 |
| 136 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.05831802 |
| 137 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.04771762 |
| 138 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.04368890 |

