WDR77

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in cancer cells. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase biosynthetic process (GO:0046112)5.05979472
2formation of translation preinitiation complex (GO:0001731)4.80059725
3purine nucleobase biosynthetic process (GO:0009113)4.78739829
4DNA unwinding involved in DNA replication (GO:0006268)4.71270625
5IMP biosynthetic process (GO:0006188)4.67315371
6DNA strand elongation involved in DNA replication (GO:0006271)4.66763568
7DNA replication initiation (GO:0006270)4.64076747
8maturation of SSU-rRNA (GO:0030490)4.56494312
9DNA strand elongation (GO:0022616)4.45309072
10ribosome assembly (GO:0042255)4.44868040
11ribosome biogenesis (GO:0042254)4.39856372
12regulation of mitochondrial translation (GO:0070129)4.23267956
13IMP metabolic process (GO:0046040)4.22879540
14telomere maintenance via semi-conservative replication (GO:0032201)4.22378801
15mitotic metaphase plate congression (GO:0007080)4.21630729
16DNA replication checkpoint (GO:0000076)4.15569771
17protein localization to kinetochore (GO:0034501)4.14570169
18DNA deamination (GO:0045006)4.12988575
19ribosomal small subunit assembly (GO:0000028)4.06993791
20mitotic nuclear envelope disassembly (GO:0007077)4.05261237
21ribonucleoprotein complex biogenesis (GO:0022613)3.95261907
22folic acid-containing compound biosynthetic process (GO:0009396)3.88181194
23nuclear pore organization (GO:0006999)3.78922887
24nucleobase-containing small molecule interconversion (GO:0015949)3.77264478
25negative regulation of ligase activity (GO:0051352)3.76558748
26negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.76558748
27membrane disassembly (GO:0030397)3.75949607
28nuclear envelope disassembly (GO:0051081)3.75949607
29ribosomal large subunit biogenesis (GO:0042273)3.75231108
30telomere maintenance via recombination (GO:0000722)3.74311760
31DNA replication-dependent nucleosome organization (GO:0034723)3.71719601
32DNA replication-dependent nucleosome assembly (GO:0006335)3.71719601
33CENP-A containing nucleosome assembly (GO:0034080)3.71165355
34chromatin remodeling at centromere (GO:0031055)3.70693769
35mitotic chromosome condensation (GO:0007076)3.66144315
36rRNA processing (GO:0006364)3.61249638
37regulation of translational fidelity (GO:0006450)3.61034866
38* spliceosomal snRNP assembly (GO:0000387)3.60101186
39chaperone-mediated protein transport (GO:0072321)3.58697090
40metaphase plate congression (GO:0051310)3.57764187
41mitotic recombination (GO:0006312)3.56786927
42establishment of protein localization to mitochondrial membrane (GO:0090151)3.54991475
43sister chromatid segregation (GO:0000819)3.50837783
44rRNA metabolic process (GO:0016072)3.49909066
45telomere maintenance via telomere lengthening (GO:0010833)3.49312344
46DNA replication-independent nucleosome organization (GO:0034724)3.44810585
47DNA replication-independent nucleosome assembly (GO:0006336)3.44810585
48pseudouridine synthesis (GO:0001522)3.44673627
49regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.44557777
50protein localization to chromosome, centromeric region (GO:0071459)3.43510828
51translational initiation (GO:0006413)3.42434800
52regulation of spindle organization (GO:0090224)3.41532370
53establishment of viral latency (GO:0019043)3.40163793
54mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.37625190
55viral transcription (GO:0019083)3.36496555
56translational termination (GO:0006415)3.36168733
57protein complex localization (GO:0031503)3.33505801
58pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.32258078
59nuclear pore complex assembly (GO:0051292)3.31578454
60L-serine metabolic process (GO:0006563)3.31197588
61protein targeting to mitochondrion (GO:0006626)3.30297845
62folic acid metabolic process (GO:0046655)3.26933320
63maturation of 5.8S rRNA (GO:0000460)3.26875649
64positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.25412189
65pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.22924774
66translational elongation (GO:0006414)3.21769062
67tRNA aminoacylation for protein translation (GO:0006418)3.21412586
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.21332078
69rRNA modification (GO:0000154)3.20637325
70ribosomal small subunit biogenesis (GO:0042274)3.20052950
71kinetochore organization (GO:0051383)3.19354788
72tRNA aminoacylation (GO:0043039)3.18613384
73amino acid activation (GO:0043038)3.18613384
74regulation of cellular amino acid metabolic process (GO:0006521)3.17800279
75negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17071732
76regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.16945577
77heterochromatin organization (GO:0070828)3.16614155
78negative regulation of chromosome segregation (GO:0051985)3.16083833
79histone exchange (GO:0043486)3.15778258
80proteasome assembly (GO:0043248)3.15358160
81DNA duplex unwinding (GO:0032508)3.14745834
82attachment of spindle microtubules to kinetochore (GO:0008608)3.14724266
83somatic diversification of immune receptors via somatic mutation (GO:0002566)3.13804774
84somatic hypermutation of immunoglobulin genes (GO:0016446)3.13804774
85negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.13547051
86negative regulation of sister chromatid segregation (GO:0033046)3.13547051
87negative regulation of mitotic sister chromatid separation (GO:2000816)3.13547051
88negative regulation of mitotic sister chromatid segregation (GO:0033048)3.13547051
89DNA geometric change (GO:0032392)3.13525247
90nucleotide-excision repair, DNA gap filling (GO:0006297)3.11510584
91positive regulation of ligase activity (GO:0051351)3.11409993
92intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.11249894
93signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.11249894
94signal transduction involved in DNA integrity checkpoint (GO:0072401)3.11089130
95signal transduction involved in DNA damage checkpoint (GO:0072422)3.11089130
96peptidyl-arginine omega-N-methylation (GO:0035247)3.10847275
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.10213812
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.10213812
99signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.10213812
100regulation of ubiquitin-protein transferase activity (GO:0051438)3.10156693
101DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.09713427
102positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.08946675
103pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.07371024
104establishment of chromosome localization (GO:0051303)3.07157459
105tRNA methylation (GO:0030488)3.06177161
106mitotic spindle assembly checkpoint (GO:0007094)3.06015846
107double-strand break repair via nonhomologous end joining (GO:0006303)3.05748643
108non-recombinational repair (GO:0000726)3.05748643
109spindle assembly checkpoint (GO:0071173)3.05133367
110spindle checkpoint (GO:0031577)3.05062920
111termination of RNA polymerase III transcription (GO:0006386)3.04756255
112transcription elongation from RNA polymerase III promoter (GO:0006385)3.04756255
113proline biosynthetic process (GO:0006561)3.04748355
114oxidative phosphorylation (GO:0006119)3.04558024
115signal transduction involved in cell cycle checkpoint (GO:0072395)3.04209451
116nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.04117355
117mitochondrial RNA metabolic process (GO:0000959)3.03870101
118negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.03666640
119histone H2A acetylation (GO:0043968)3.03133115
120negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.02449733
121cell cycle G1/S phase transition (GO:0044843)3.02178924
122G1/S transition of mitotic cell cycle (GO:0000082)3.02178924
123transcription-coupled nucleotide-excision repair (GO:0006283)3.02111709
124translation (GO:0006412)3.01881644
125kinetochore assembly (GO:0051382)3.00862124
126negative regulation of mRNA processing (GO:0050686)3.00486147
127histone arginine methylation (GO:0034969)2.99528138
128regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.99441041
129RNA splicing, via transesterification reactions (GO:0000375)2.99224492
130mitotic spindle checkpoint (GO:0071174)2.98923671
131mRNA splicing, via spliceosome (GO:0000398)2.98099136
132RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.98099136
133establishment of integrated proviral latency (GO:0075713)2.95697882
134termination of RNA polymerase I transcription (GO:0006363)2.95292536
135mitotic sister chromatid segregation (GO:0000070)2.95187573
136cellular component biogenesis (GO:0044085)2.95027392
137viral mRNA export from host cell nucleus (GO:0046784)2.94715992
138spliceosomal complex assembly (GO:0000245)2.94223961
139transcription from RNA polymerase I promoter (GO:0006360)2.92200901
140regulation of centrosome cycle (GO:0046605)2.91797612
141regulation of chromosome segregation (GO:0051983)2.91730938

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.10656569
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.72728282
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.86630956
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.46455036
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.43910871
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.25648548
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.06822824
8* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.05367480
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.03238077
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.98087421
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92517299
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91043046
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.90559246
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.79642580
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.60673454
16* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.60369450
17* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.48313709
18XRN2_22483619_ChIP-Seq_HELA_Human2.44383841
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28246412
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21185414
21VDR_23849224_ChIP-Seq_CD4+_Human2.20539360
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14064222
23AR_21909140_ChIP-Seq_LNCAP_Human2.13985449
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11081530
25* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02278697
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.01828203
27GABP_19822575_ChIP-Seq_HepG2_Human1.99093165
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.98090812
29FOXP3_21729870_ChIP-Seq_TREG_Human1.96394413
30DCP1A_22483619_ChIP-Seq_HELA_Human1.95822535
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.94055489
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.93251128
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.92918821
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90718906
35* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.89814912
36TTF2_22483619_ChIP-Seq_HELA_Human1.89807549
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.89053674
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81855323
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78806984
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.73919684
41* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73718615
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71986063
43CIITA_25753668_ChIP-Seq_RAJI_Human1.65307032
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.60126392
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.58559235
46MYC_22102868_ChIP-Seq_BL_Human1.58535158
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58117314
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57011178
49ELK1_19687146_ChIP-ChIP_HELA_Human1.56319511
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55516200
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54693519
52KDM5A_27292631_Chip-Seq_BREAST_Human1.52903025
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41675051
54ZNF263_19887448_ChIP-Seq_K562_Human1.41447076
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.39144504
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36686381
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34854503
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.34415936
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33934322
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32397812
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31311933
62* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30830035
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30508644
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30417213
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28257324
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.26459687
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.21882132
68* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20800364
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20138500
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17955401
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15839372
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14836089
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14789360
74TFEB_21752829_ChIP-Seq_HELA_Human1.11960174
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11280752
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11227419
77PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10868567
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10315468
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10205936
80* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09622743
81* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08705187
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04247806
83* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03949858
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03519683
85TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02593921
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02063043
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02026845
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01282966
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01052650
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00491651
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00209356
92* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98861130
93NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95795777
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95333667
95MYC_18940864_ChIP-ChIP_HL60_Human0.94292173
96KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94156589
97KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94156589
98KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94156589
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93590285
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93106100
101SOX17_20123909_ChIP-Seq_XEN_Mouse0.92912953
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92157325
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91875679
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90885087
105TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90466323
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89868318
107NANOG_21062744_ChIP-ChIP_HESCs_Human0.89713738
108TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.88282750
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86648137
110HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85769806
111ELK1_22589737_ChIP-Seq_MCF10A_Human0.85626287
112OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84550121
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84518596
114* CHD1_26751641_Chip-Seq_LNCaP_Human0.84130797
115SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83853586
116ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83151364
117SALL1_21062744_ChIP-ChIP_HESCs_Human0.80345750

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.63590628
2MP0004957_abnormal_blastocyst_morpholog4.71932158
3MP0010094_abnormal_chromosome_stability4.59869462
4MP0003111_abnormal_nucleus_morphology4.56349349
5MP0003077_abnormal_cell_cycle4.03219602
6MP0008057_abnormal_DNA_replication3.76940237
7MP0008058_abnormal_DNA_repair3.52951515
8MP0003123_paternal_imprinting3.48703155
9MP0008007_abnormal_cellular_replicative2.97492201
10MP0008932_abnormal_embryonic_tissue2.79116782
11MP0001730_embryonic_growth_arrest2.63803600
12MP0002396_abnormal_hematopoietic_system2.42217097
13MP0000350_abnormal_cell_proliferation2.35666748
14MP0010030_abnormal_orbit_morphology2.10490897
15MP0010352_gastrointestinal_tract_polyps2.08598700
16MP0008877_abnormal_DNA_methylation2.07344719
17MP0003786_premature_aging2.03315486
18MP0001672_abnormal_embryogenesis/_devel1.96983333
19MP0005380_embryogenesis_phenotype1.96983333
20MP0001697_abnormal_embryo_size1.93638900
21* MP0002080_prenatal_lethality1.77042665
22MP0003984_embryonic_growth_retardation1.77002319
23MP0003890_abnormal_embryonic-extraembry1.74635820
24MP0002088_abnormal_embryonic_growth/wei1.73073990
25MP0002085_abnormal_embryonic_tissue1.71718478
26MP0006292_abnormal_olfactory_placode1.66750301
27MP0002084_abnormal_developmental_patter1.64713817
28MP0003718_maternal_effect1.62735979
29MP0004197_abnormal_fetal_growth/weight/1.59673536
30MP0004808_abnormal_hematopoietic_stem1.59627926
31MP0001293_anophthalmia1.59286437
32MP0005451_abnormal_body_composition1.59152852
33MP0003567_abnormal_fetal_cardiomyocyte1.58267209
34MP0000490_abnormal_crypts_of1.54394482
35MP0010307_abnormal_tumor_latency1.54190096
36MP0002086_abnormal_extraembryonic_tissu1.51665713
37MP0003806_abnormal_nucleotide_metabolis1.51535076
38MP0000313_abnormal_cell_death1.45874401
39MP0003121_genomic_imprinting1.44458020
40MP0001661_extended_life_span1.41364875
41MP0004133_heterotaxia1.37748421
42MP0002019_abnormal_tumor_incidence1.31014523
43MP0002877_abnormal_melanocyte_morpholog1.28568279
44MP0002210_abnormal_sex_determination1.27712693
45MP0005501_abnormal_skin_physiology1.23591902
46MP0005397_hematopoietic_system_phenotyp1.23485609
47MP0001545_abnormal_hematopoietic_system1.23485609
48MP0003119_abnormal_digestive_system1.19723842
49MP0005623_abnormal_meninges_morphology1.17008071
50MP0002160_abnormal_reproductive_system1.16947605
51MP0002163_abnormal_gland_morphology1.15409446
52MP0000537_abnormal_urethra_morphology1.15255181
53MP0003221_abnormal_cardiomyocyte_apopto1.14742219
54* MP0001145_abnormal_male_reproductive1.11622059
55MP0003315_abnormal_perineum_morphology1.11206210
56MP0001346_abnormal_lacrimal_gland1.07600213
57MP0009333_abnormal_splenocyte_physiolog1.07321206
58MP0001727_abnormal_embryo_implantation1.06923523
59MP0000749_muscle_degeneration1.02740326
60MP0000358_abnormal_cell_content/1.02056750
61MP0009672_abnormal_birth_weight1.01326273
62MP0001529_abnormal_vocalization1.00643032
63MP0002796_impaired_skin_barrier1.00051256
64MP0000678_abnormal_parathyroid_gland0.96251697
65MP0003941_abnormal_skin_development0.92778710
66MP0002653_abnormal_ependyma_morphology0.92749712
67MP0002697_abnormal_eye_size0.92327437
68MP0001929_abnormal_gametogenesis0.91926976
69* MP0000653_abnormal_sex_gland0.91110976
70MP0005330_cardiomyopathy0.90812777
71MP0002111_abnormal_tail_morphology0.90583278
72MP0005389_reproductive_system_phenotype0.86146153
73MP0009697_abnormal_copulation0.86011219
74MP0000703_abnormal_thymus_morphology0.85387636
75MP0006054_spinal_hemorrhage0.85357025
76MP0009379_abnormal_foot_pigmentation0.84981314
77MP0005384_cellular_phenotype0.82202252
78MP0009053_abnormal_anal_canal0.81564847
79MP0002938_white_spotting0.81305604
80MP0000762_abnormal_tongue_morphology0.80223832
81MP0008260_abnormal_autophagy0.79926159
82MP0005187_abnormal_penis_morphology0.78542942
83MP0001881_abnormal_mammary_gland0.78301496
84MP0003186_abnormal_redox_activity0.77214197
85MP0000428_abnormal_craniofacial_morphol0.77116173
86MP0004233_abnormal_muscle_weight0.75746474
87MP0001119_abnormal_female_reproductive0.75632179
88MP0005075_abnormal_melanosome_morpholog0.75526581
89MP0009703_decreased_birth_body0.75308009
90MP0002722_abnormal_immune_system0.74457083
91MP0008789_abnormal_olfactory_epithelium0.74090097
92MP0001915_intracranial_hemorrhage0.73875871
93MP0003385_abnormal_body_wall0.73260971
94MP0005076_abnormal_cell_differentiation0.72851423
95MP0006035_abnormal_mitochondrial_morpho0.72809123
96MP0004185_abnormal_adipocyte_glucose0.72601007
97MP0004147_increased_porphyrin_level0.71671573
98MP0002132_abnormal_respiratory_system0.71436600
99MP0005621_abnormal_cell_physiology0.70782979
100MP0000689_abnormal_spleen_morphology0.70194758
101MP0002398_abnormal_bone_marrow0.69834248
102MP0002269_muscular_atrophy0.68743941
103MP0002092_abnormal_eye_morphology0.68238839
104MP0003763_abnormal_thymus_physiology0.65926775
105MP0001849_ear_inflammation0.65773074
106MP0000627_abnormal_mammary_gland0.65430636
107MP0006036_abnormal_mitochondrial_physio0.64475404
108MP0003937_abnormal_limbs/digits/tail_de0.64354463
109MP0001286_abnormal_eye_development0.64269592
110MP0001764_abnormal_homeostasis0.62665696
111MP0003705_abnormal_hypodermis_morpholog0.61916750
112MP0002075_abnormal_coat/hair_pigmentati0.61039438
113MP0005023_abnormal_wound_healing0.60912661
114MP0005266_abnormal_metabolism0.60561606
115MP0000750_abnormal_muscle_regeneration0.60457442
116MP0005408_hypopigmentation0.59885466
117MP0004084_abnormal_cardiac_muscle0.59789553
118MP0000858_altered_metastatic_potential0.58106620
119MP0002095_abnormal_skin_pigmentation0.57690763
120MP0002233_abnormal_nose_morphology0.57550964
121MP0003942_abnormal_urinary_system0.57358991
122MP0003566_abnormal_cell_adhesion0.57291375
123MP0001919_abnormal_reproductive_system0.57153505
124MP0009278_abnormal_bone_marrow0.56652769
125MP0000049_abnormal_middle_ear0.56321013
126MP0000747_muscle_weakness0.55901323
127MP0000759_abnormal_skeletal_muscle0.55657033
128MP0000477_abnormal_intestine_morphology0.55358881
129MP0010630_abnormal_cardiac_muscle0.54830597
130MP0003936_abnormal_reproductive_system0.54687679
131MP0002114_abnormal_axial_skeleton0.54399186
132MP0009250_abnormal_appendicular_skeleto0.51255423

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.07152508
2Microvesicular hepatic steatosis (HP:0001414)4.46136702
3Breast hypoplasia (HP:0003187)4.08605525
4Selective tooth agenesis (HP:0001592)3.90381360
5Reticulocytopenia (HP:0001896)3.69905337
6Colon cancer (HP:0003003)3.67419818
7Oral leukoplakia (HP:0002745)3.66729966
8Increased serum pyruvate (HP:0003542)3.64481868
9Abnormal mitochondria in muscle tissue (HP:0008316)3.59415594
10Abnormality of glycolysis (HP:0004366)3.57196895
11Acute necrotizing encephalopathy (HP:0006965)3.53797237
12Abnormality of the anterior horn cell (HP:0006802)3.52837606
13Degeneration of anterior horn cells (HP:0002398)3.52837606
14Abnormality of cells of the erythroid lineage (HP:0012130)3.48545721
15Cerebral hypomyelination (HP:0006808)3.47619647
16Medulloblastoma (HP:0002885)3.41544004
17Ependymoma (HP:0002888)3.36803115
18Aplastic anemia (HP:0001915)3.34139963
19Abnormal number of erythroid precursors (HP:0012131)3.32592555
20Patellar aplasia (HP:0006443)3.30612541
21Acute encephalopathy (HP:0006846)3.29003652
22Rough bone trabeculation (HP:0100670)3.14005865
23Aplasia/Hypoplasia of the patella (HP:0006498)3.12795596
24Carpal bone hypoplasia (HP:0001498)3.12081902
25Increased CSF lactate (HP:0002490)3.11132317
26Ragged-red muscle fibers (HP:0003200)3.09384833
27Decreased activity of mitochondrial respiratory chain (HP:0008972)3.05031295
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.05031295
29Meckel diverticulum (HP:0002245)3.04699977
30Mitochondrial inheritance (HP:0001427)2.97929648
31Abnormality of the preputium (HP:0100587)2.97495933
32Chromsome breakage (HP:0040012)2.96709626
33Increased hepatocellular lipid droplets (HP:0006565)2.95775530
34Abnormality of the ileum (HP:0001549)2.93816878
35Increased serum lactate (HP:0002151)2.90190961
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.85062215
37Abnormality of chromosome stability (HP:0003220)2.83234509
38Hepatocellular necrosis (HP:0001404)2.79366370
39Absent thumb (HP:0009777)2.77090823
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.75974908
41Impulsivity (HP:0100710)2.73499741
42Cerebral edema (HP:0002181)2.72316657
43Lipid accumulation in hepatocytes (HP:0006561)2.72023788
44Trismus (HP:0000211)2.70542411
45Exercise intolerance (HP:0003546)2.67914792
46Supernumerary spleens (HP:0009799)2.66782566
47Agnosia (HP:0010524)2.66487752
48Abnormality of the labia minora (HP:0012880)2.64720477
49Lactic acidosis (HP:0003128)2.63454438
50Abnormality of the fetal cardiovascular system (HP:0010948)2.63125202
51Abnormal umbilical cord blood vessels (HP:0011403)2.63125202
52Single umbilical artery (HP:0001195)2.63125202
53Increased intramyocellular lipid droplets (HP:0012240)2.62965008
54Multiple enchondromatosis (HP:0005701)2.61920081
55Absent radius (HP:0003974)2.61628339
56Microretrognathia (HP:0000308)2.60412143
57Myelodysplasia (HP:0002863)2.59118895
58Reduced antithrombin III activity (HP:0001976)2.56464774
59Progressive macrocephaly (HP:0004481)2.53438680
60Neoplasm of the pancreas (HP:0002894)2.52016607
61Hepatic necrosis (HP:0002605)2.51734025
62Macrocytic anemia (HP:0001972)2.49518500
6311 pairs of ribs (HP:0000878)2.46915769
64Aplasia involving forearm bones (HP:0009822)2.44180300
65Absent forearm bone (HP:0003953)2.44180300
66Premature graying of hair (HP:0002216)2.44010657
67Abnormal lung lobation (HP:0002101)2.43648407
68Small intestinal stenosis (HP:0012848)2.43196689
69Duodenal stenosis (HP:0100867)2.43196689
70Abnormal number of incisors (HP:0011064)2.38481144
71Basal cell carcinoma (HP:0002671)2.38222133
72Rhabdomyosarcoma (HP:0002859)2.33158553
73Bone marrow hypocellularity (HP:0005528)2.30864758
74Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.30174551
75Progressive external ophthalmoplegia (HP:0000590)2.28608720
76Tracheoesophageal fistula (HP:0002575)2.25780680
77Premature ovarian failure (HP:0008209)2.25456073
78Atrophy/Degeneration involving motor neurons (HP:0007373)2.25219097
79Spastic diplegia (HP:0001264)2.24206243
80Pancytopenia (HP:0001876)2.23522267
81Pallor (HP:0000980)2.23498884
82Increased muscle lipid content (HP:0009058)2.23340942
83Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.21623188
84Sloping forehead (HP:0000340)2.19670138
85Atresia of the external auditory canal (HP:0000413)2.18882176
86Abnormal trabecular bone morphology (HP:0100671)2.17027421
87Glossoptosis (HP:0000162)2.17002991
88Squamous cell carcinoma (HP:0002860)2.16952398
89Missing ribs (HP:0000921)2.16769082
90Cellular immunodeficiency (HP:0005374)2.14863358
91CNS hypomyelination (HP:0003429)2.14195034
92Horseshoe kidney (HP:0000085)2.12732849
93Testicular atrophy (HP:0000029)2.11541872
94Respiratory difficulties (HP:0002880)2.11362280
95Abnormalities of placenta or umbilical cord (HP:0001194)2.11262030
96Proximal placement of thumb (HP:0009623)2.09838056
97Renal Fanconi syndrome (HP:0001994)2.09489826
98Abnormality of the duodenum (HP:0002246)2.07966606
99Abnormal protein glycosylation (HP:0012346)2.07174200
100Abnormal glycosylation (HP:0012345)2.07174200
101Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.07174200
102Abnormal protein N-linked glycosylation (HP:0012347)2.07174200
103Cleft eyelid (HP:0000625)2.05773437
104Increased nuchal translucency (HP:0010880)2.05402346
105Facial cleft (HP:0002006)2.05073733
106Abnormality of the musculature of the pelvis (HP:0001469)2.04892281
107Abnormality of the hip-girdle musculature (HP:0001445)2.04892281
108Postnatal microcephaly (HP:0005484)2.04107272
109Muscle fiber atrophy (HP:0100295)2.03980558
110Abnormality of the carotid arteries (HP:0005344)2.03235181
111Secondary amenorrhea (HP:0000869)2.03224809
112Triphalangeal thumb (HP:0001199)2.02953591
113Slender long bone (HP:0003100)1.99847182
114Astrocytoma (HP:0009592)1.98776994
115Abnormality of the astrocytes (HP:0100707)1.98776994
116Deviation of the thumb (HP:0009603)1.97662159
117Gout (HP:0001997)1.97617091
118Glioma (HP:0009733)1.97338380
119Thrombocytosis (HP:0001894)1.96514802
120Type I transferrin isoform profile (HP:0003642)1.95493525
121Abnormality of methionine metabolism (HP:0010901)1.95450872
122Aplasia/Hypoplasia of the sternum (HP:0006714)1.93663071
123Aplasia/Hypoplasia of the sacrum (HP:0008517)1.93526893
124Type 2 muscle fiber atrophy (HP:0003554)1.93025833
125Megaloblastic anemia (HP:0001889)1.92727534
126Sparse eyelashes (HP:0000653)1.92698954
127Respiratory failure (HP:0002878)1.92645989
128Stenosis of the external auditory canal (HP:0000402)1.86586061
129Neoplasm of the colon (HP:0100273)1.86252904
130Spinal muscular atrophy (HP:0007269)1.85890906
131Amaurosis fugax (HP:0100576)1.85087699
132Abnormality of abdominal situs (HP:0011620)1.83605416
133Abdominal situs inversus (HP:0003363)1.83605416
134Entropion (HP:0000621)1.83474586
135Hypoplasia of the radius (HP:0002984)1.83472254
136Optic nerve coloboma (HP:0000588)1.83329511
137Leukodystrophy (HP:0002415)1.83024383
138Abnormality of the umbilical cord (HP:0010881)1.82261176
139Aplasia/hypoplasia of the humerus (HP:0006507)1.80720239
140Facial hemangioma (HP:0000329)1.80257398
141Pelvic girdle muscle weakness (HP:0003749)1.80112984
142Neoplasm of the oral cavity (HP:0100649)1.79205399
143Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78727680
144Abnormality of alanine metabolism (HP:0010916)1.78727680
145Hyperalaninemia (HP:0003348)1.78727680
146Progressive muscle weakness (HP:0003323)1.78716188
147Nephroblastoma (Wilms tumor) (HP:0002667)1.77708444
148Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76925658
149Broad distal phalanx of finger (HP:0009836)1.75825924

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.83838776
2WEE14.75402881
3CDC73.70028646
4PBK3.62803035
5VRK23.58914889
6EIF2AK13.26352927
7TSSK62.80093200
8SRPK12.55337178
9BRSK22.53668323
10NEK12.42411934
11STK162.42181404
12ACVR1B2.41945149
13NEK22.38377737
14MKNK12.31733686
15PLK42.18810389
16PASK2.18625921
17EIF2AK32.18583263
18SMG12.18490937
19NME22.09276574
20TTK2.04630186
21PLK11.98260945
22MKNK21.96739746
23CDK71.94739257
24ATR1.72710894
25PLK31.71414208
26DYRK31.68295000
27RPS6KB21.66066717
28VRK11.60541601
29RPS6KA41.55483873
30AURKB1.51166761
31EPHA21.50392138
32BRSK11.50114916
33CDK121.42901861
34SCYL21.39642490
35TESK21.38499199
36MAP3K81.33668170
37TAF11.32038987
38EEF2K1.30621326
39CHEK21.29664461
40TGFBR11.28501197
41AURKA1.25831079
42IRAK31.19141718
43CHEK11.16366630
44PAK41.15086362
45FLT31.10202131
46TLK11.03745286
47ALK0.98735243
48MST40.98255954
49CCNB10.93921253
50LATS20.93614952
51CSNK1G30.92174222
52BCKDK0.90407096
53* CDK40.87800495
54CDK20.85535443
55CLK10.83153515
56BRD40.82605076
57MAP3K100.79544465
58PKN20.78311118
59ATM0.76959828
60ARAF0.76545997
61CSNK2A20.76195869
62STK100.75479241
63TAOK20.75277907
64PIM20.74490721
65TRIM280.73944546
66CSNK1A1L0.73034868
67PDK30.71922751
68PDK40.71922751
69MAP3K110.71600370
70ZAK0.70813355
71PAK10.69128848
72CSNK1G10.67238996
73PIM10.66580798
74CSNK2A10.66169906
75STK40.64872037
76CDK80.63459763
77PRKCI0.61139709
78CDK10.58961232
79PNCK0.58367740
80MAP2K30.55984362
81CDK60.55320532
82ABL20.51310333
83MAPKAPK30.50770508
84TESK10.50762548
85EIF2AK20.50313784
86KDR0.50237915
87NUAK10.49875048
88CSNK1G20.47865306
89MELK0.47108285
90TRIB30.45360757
91BRAF0.45274112
92MST1R0.44550148
93MTOR0.43022528
94AKT20.42876725
95CSNK1E0.40870800
96FGFR10.40551717
97ERBB40.39165545
98CDK140.38807162
99LRRK20.37826395
100STK38L0.37077803
101LATS10.36527878
102CDK11A0.35062850
103STK30.34929551
104AKT30.34739565
105CDK150.33138962
106CDK180.32807647
107CDK90.32477361
108PDK20.32471338
109CDK190.32430680
110ICK0.31236238
111PAK20.29860396
112PRKDC0.29497236
113DAPK30.28825900
114MATK0.27796601
115RPS6KB10.27078575
116DAPK10.26573397
117LIMK10.25356924
118MAP3K50.25067100
119BTK0.24823451
120RAF10.24581576
121MAP4K10.23676384
122NME10.22708486
123DYRK20.21787561
124RPS6KA50.21767847
125KIT0.21099885
126ILK0.18631333

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.87511946
2Mismatch repair_Homo sapiens_hsa034304.16566185
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.12883464
4RNA polymerase_Homo sapiens_hsa030203.63939386
5Spliceosome_Homo sapiens_hsa030403.50968427
6RNA transport_Homo sapiens_hsa030133.45395386
7Proteasome_Homo sapiens_hsa030503.40112933
8Ribosome_Homo sapiens_hsa030103.28187653
9Base excision repair_Homo sapiens_hsa034103.00033141
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.92491476
11Homologous recombination_Homo sapiens_hsa034402.79410187
12Nucleotide excision repair_Homo sapiens_hsa034202.79066044
13One carbon pool by folate_Homo sapiens_hsa006702.75214610
14Cell cycle_Homo sapiens_hsa041102.69775172
15Pyrimidine metabolism_Homo sapiens_hsa002402.61423337
16Fanconi anemia pathway_Homo sapiens_hsa034602.11141641
17Basal transcription factors_Homo sapiens_hsa030221.95540803
18RNA degradation_Homo sapiens_hsa030181.93216128
19Oxidative phosphorylation_Homo sapiens_hsa001901.89192824
20mRNA surveillance pathway_Homo sapiens_hsa030151.77818886
21Non-homologous end-joining_Homo sapiens_hsa034501.73595339
22p53 signaling pathway_Homo sapiens_hsa041151.55805310
23Purine metabolism_Homo sapiens_hsa002301.47351647
24Pyruvate metabolism_Homo sapiens_hsa006201.44362938
25Vitamin B6 metabolism_Homo sapiens_hsa007501.26008900
26Biosynthesis of amino acids_Homo sapiens_hsa012301.25515428
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.23205044
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20368964
29Epstein-Barr virus infection_Homo sapiens_hsa051691.20228815
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.13094133
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07502178
32Alzheimers disease_Homo sapiens_hsa050101.06367030
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04919641
34Fatty acid elongation_Homo sapiens_hsa000621.04191926
35Oocyte meiosis_Homo sapiens_hsa041141.03946458
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02825630
37Pentose phosphate pathway_Homo sapiens_hsa000301.02672509
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98000177
39Folate biosynthesis_Homo sapiens_hsa007900.96195432
40Selenocompound metabolism_Homo sapiens_hsa004500.93773333
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93145224
42Thyroid cancer_Homo sapiens_hsa052160.88140383
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85415837
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84866096
45Viral carcinogenesis_Homo sapiens_hsa052030.79999750
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79826622
47Herpes simplex infection_Homo sapiens_hsa051680.75925013
48Sulfur relay system_Homo sapiens_hsa041220.74721003
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.74696543
50Antigen processing and presentation_Homo sapiens_hsa046120.74474804
51Carbon metabolism_Homo sapiens_hsa012000.73780481
52Propanoate metabolism_Homo sapiens_hsa006400.69306070
53Systemic lupus erythematosus_Homo sapiens_hsa053220.68872228
54HTLV-I infection_Homo sapiens_hsa051660.65279765
55Steroid biosynthesis_Homo sapiens_hsa001000.63087939
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59027043
57Fructose and mannose metabolism_Homo sapiens_hsa000510.54588284
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54350917
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53813978
60N-Glycan biosynthesis_Homo sapiens_hsa005100.53718901
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52608365
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49604133
63MicroRNAs in cancer_Homo sapiens_hsa052060.49210921
64Legionellosis_Homo sapiens_hsa051340.48825431
65Glutathione metabolism_Homo sapiens_hsa004800.46957738
66Cardiac muscle contraction_Homo sapiens_hsa042600.46569973
67Protein export_Homo sapiens_hsa030600.46542110
68Hippo signaling pathway_Homo sapiens_hsa043900.44742754
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43509417
70Basal cell carcinoma_Homo sapiens_hsa052170.42901621
71Sulfur metabolism_Homo sapiens_hsa009200.42839514
72Small cell lung cancer_Homo sapiens_hsa052220.42024626
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.41405704
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41229286
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41048742
76TGF-beta signaling pathway_Homo sapiens_hsa043500.39032813
77Huntingtons disease_Homo sapiens_hsa050160.38269732
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37153676
79Galactose metabolism_Homo sapiens_hsa000520.35190031
80Notch signaling pathway_Homo sapiens_hsa043300.34545340
81Fatty acid metabolism_Homo sapiens_hsa012120.34505613
82HIF-1 signaling pathway_Homo sapiens_hsa040660.34109994
83Phenylalanine metabolism_Homo sapiens_hsa003600.32811063
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31317001
85Arginine biosynthesis_Homo sapiens_hsa002200.29562874
86Colorectal cancer_Homo sapiens_hsa052100.29221902
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26864541
88Apoptosis_Homo sapiens_hsa042100.25891888
89Bladder cancer_Homo sapiens_hsa052190.23837448
90Metabolic pathways_Homo sapiens_hsa011000.23814141
91mTOR signaling pathway_Homo sapiens_hsa041500.23810882
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23458964
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22305268
94Vibrio cholerae infection_Homo sapiens_hsa051100.20571581
95Shigellosis_Homo sapiens_hsa051310.20408133
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19527975
97Hedgehog signaling pathway_Homo sapiens_hsa043400.19498761
98Lysine degradation_Homo sapiens_hsa003100.18467652
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18150934
100Pathways in cancer_Homo sapiens_hsa052000.17632315
101Hepatitis B_Homo sapiens_hsa051610.17172011
102Viral myocarditis_Homo sapiens_hsa054160.16586164
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16052730
104Regulation of autophagy_Homo sapiens_hsa041400.15955267
105Acute myeloid leukemia_Homo sapiens_hsa052210.15115674
106Tyrosine metabolism_Homo sapiens_hsa003500.14953796
107Alcoholism_Homo sapiens_hsa050340.14531074
108Peroxisome_Homo sapiens_hsa041460.13117017
109Parkinsons disease_Homo sapiens_hsa050120.11588480
110Arginine and proline metabolism_Homo sapiens_hsa003300.10985401
111Chronic myeloid leukemia_Homo sapiens_hsa052200.10876415
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.09988807
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.09406714
114beta-Alanine metabolism_Homo sapiens_hsa004100.08081078
115Influenza A_Homo sapiens_hsa051640.07925919
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.07884881
117Wnt signaling pathway_Homo sapiens_hsa043100.07851630
118Primary immunodeficiency_Homo sapiens_hsa053400.07591080
119Fatty acid degradation_Homo sapiens_hsa000710.07458196
120Measles_Homo sapiens_hsa051620.07093085
121Adherens junction_Homo sapiens_hsa045200.06228085
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.05867977
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.05672567
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.05523710
125Renin-angiotensin system_Homo sapiens_hsa046140.05523451

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