ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	8.22065887
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	7.37581196
3	ATP synthesis coupled proton transport (GO:0015986)	7.37581196
4	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	6.28571481
5	ribosomal small subunit assembly (GO:0000028)	6.25295317
6	respiratory electron transport chain (GO:0022904)	6.10152426
7	electron transport chain (GO:0022900)	6.00341193
8	DNA deamination (GO:0045006)	5.74400727
9	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.58770493
10	proteasome assembly (GO:0043248)	4.63254494
11	protein neddylation (GO:0045116)	4.42841849
12	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.22722861
13	hydrogen ion transmembrane transport (GO:1902600)	4.20665158
14	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.20206808
15	viral transcription (GO:0019083)	4.18216825
16	ATP biosynthetic process (GO:0006754)	4.16905461
17	translational termination (GO:0006415)	4.07821591
18	cotranslational protein targeting to membrane (GO:0006613)	4.07304046
19	protein targeting to ER (GO:0045047)	4.04309183
20	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.99987245
21	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.98544975
22	protein localization to endoplasmic reticulum (GO:0070972)	3.92082388
23	signal peptide processing (GO:0006465)	3.88114592
24	response to interferon-beta (GO:0035456)	3.84851340
25	proton transport (GO:0015992)	3.81523082
26	translational elongation (GO:0006414)	3.79609960
27	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.78648979
28	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.78575794
29	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.78475277
30	hydrogen transport (GO:0006818)	3.74172954
31	protein targeting to mitochondrion (GO:0006626)	3.72708460
32	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.69449176
33	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.67420782
34	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.67420782
35	establishment of protein localization to mitochondrion (GO:0072655)	3.60660732
36	formation of translation preinitiation complex (GO:0001731)	3.57288763
37	ribosomal small subunit biogenesis (GO:0042274)	3.55875746
38	maturation of SSU-rRNA (GO:0030490)	3.55530298
39	inner mitochondrial membrane organization (GO:0007007)	3.54851420
40	protein localization to mitochondrion (GO:0070585)	3.50734282
41	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.49358946
42	telomere maintenance via semi-conservative replication (GO:0032201)	3.48392342
43	regulation of cellular amino acid metabolic process (GO:0006521)	3.48118261
44	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.45186236
45	sequestering of actin monomers (GO:0042989)	3.45052044
46	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.43691157
47	translation (GO:0006412)	3.43169393
48	pseudouridine synthesis (GO:0001522)	3.40770459
49	negative regulation of ligase activity (GO:0051352)	3.40635415
50	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.40635415
51	GTP biosynthetic process (GO:0006183)	3.40403433
52	protein-cofactor linkage (GO:0018065)	3.38319264
53	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.37829259
54	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.37829259
55	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.37754725
56	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.37486061
57	mannosylation (GO:0097502)	3.37354999
58	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.36855204
59	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.36855204
60	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.36855204
61	viral life cycle (GO:0019058)	3.33721000
62	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.31811128
63	translational initiation (GO:0006413)	3.31300495
64	iron-sulfur cluster assembly (GO:0016226)	3.30388349
65	metallo-sulfur cluster assembly (GO:0031163)	3.30388349
66	base-excision repair, AP site formation (GO:0006285)	3.25114108
67	respiratory chain complex IV assembly (GO:0008535)	3.22790303
68	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.20052388
69	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.20052388
70	mitochondrial transport (GO:0006839)	3.19563203
71	cytochrome complex assembly (GO:0017004)	3.18258687
72	termination of RNA polymerase III transcription (GO:0006386)	3.18140195
73	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.18140195
74	regulation of cellular amine metabolic process (GO:0033238)	3.17641601
75	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.16434915
76	intracellular protein transmembrane import (GO:0044743)	3.16091204
77	purine-containing compound salvage (GO:0043101)	3.15297244
78	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.14993725
79	cellular protein complex disassembly (GO:0043624)	3.14942721
80	ribosomal large subunit biogenesis (GO:0042273)	3.13890454
81	nucleoside triphosphate biosynthetic process (GO:0009142)	3.13320628
82	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.13088321
83	DNA strand elongation involved in DNA replication (GO:0006271)	3.13001887
84	GDP-mannose metabolic process (GO:0019673)	3.12797327
85	water-soluble vitamin biosynthetic process (GO:0042364)	3.08644203
86	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.08408169
87	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	3.07309436
88	2-deoxyribonucleotide biosynthetic process (GO:0009265)	3.07065923
89	deoxyribose phosphate biosynthetic process (GO:0046385)	3.07065923
90	telomere maintenance via recombination (GO:0000722)	3.06007714
91	DNA strand elongation (GO:0022616)	3.05210788
92	protein deneddylation (GO:0000338)	3.03126393
93	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.01241739
94	protein maturation by protein folding (GO:0022417)	2.99963690
95	guanosine-containing compound biosynthetic process (GO:1901070)	2.99205214
96	regulation of mitochondrial translation (GO:0070129)	2.96633926
97	oxidative phosphorylation (GO:0006119)	2.95053361
98	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.94632971
99	cullin deneddylation (GO:0010388)	2.91164500
100	protein complex biogenesis (GO:0070271)	2.90646241
101	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.89618826
102	chaperone-mediated protein transport (GO:0072321)	2.89429725
103	nucleobase-containing small molecule interconversion (GO:0015949)	2.89302597
104	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.85443562
105	positive regulation of ligase activity (GO:0051351)	2.84725514
106	rRNA modification (GO:0000154)	2.84114852
107	ribonucleoprotein complex biogenesis (GO:0022613)	2.80358197
108	platelet dense granule organization (GO:0060155)	2.78067809
109	7-methylguanosine mRNA capping (GO:0006370)	2.77504440
110	mitochondrial respiratory chain complex assembly (GO:0033108)	2.74033302
111	protein complex disassembly (GO:0043241)	2.72660910
112	7-methylguanosine RNA capping (GO:0009452)	2.72202153
113	RNA capping (GO:0036260)	2.72202153
114	endosome to melanosome transport (GO:0035646)	2.71265826
115	endosome to pigment granule transport (GO:0043485)	2.71265826
116	positive regulation of cell cycle arrest (GO:0071158)	2.71135132
117	L-methionine salvage (GO:0071267)	2.70710999
118	L-methionine biosynthetic process (GO:0071265)	2.70710999
119	amino acid salvage (GO:0043102)	2.70710999
120	cellular component biogenesis (GO:0044085)	2.69055581
121	cellular response to interferon-beta (GO:0035458)	2.68842440
122	peptidyl-histidine modification (GO:0018202)	2.68401633
123	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.65498246
124	protein targeting to membrane (GO:0006612)	2.65480543
125	spliceosomal snRNP assembly (GO:0000387)	2.63935841
126	negative regulation of release of cytochrome c from mitochondria (GO:0090201)	2.61922672
127	deoxyribonucleotide biosynthetic process (GO:0009263)	2.61487189
128	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.61315444
129	macromolecular complex disassembly (GO:0032984)	2.60315378
130	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.59926219
131	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.59926219
132	NADH dehydrogenase complex assembly (GO:0010257)	2.59926219
133	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.56728905

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	4.05513808
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.80851406
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.56058435
4	E2F7_22180533_ChIP-Seq_HELA_Human	3.51790500
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.51632044
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.45488619
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.35143493
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.24751545
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.18123713
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.95624644
11	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.71216548
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.67054448
13	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	2.57927273
14	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.54219985
15	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.53976295
16	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.51655445
17	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	2.36750793
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.32046036
19	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.30620075
20	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.30500564
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.27269261
22	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.24255173
23	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	2.19200812
24	XRN2_22483619_ChIP-Seq_HELA_Human	2.13222486
25	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.10808789
26	DCP1A_22483619_ChIP-Seq_HELA_Human	2.10567590
27	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.01316357
28	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.00617832
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.99227957
30	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.95835428
31	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.95829044
32	GABP_19822575_ChIP-Seq_HepG2_Human	1.92923231
33	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.88285639
34	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.86234776
35	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.84476041
36	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.81218129
37	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.79356127
38	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.73827716
39	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.72626290
40	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.71393177
41	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.70904027
42	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.70686986
43	ELK1_19687146_ChIP-ChIP_HELA_Human	1.70570377
44	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.70358729
45	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.68901303
46	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.63287182
47	MYC_18940864_ChIP-ChIP_HL60_Human	1.61878684
48	SPI1_23547873_ChIP-Seq_NB4_Human	1.61710951
49	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.61406452
50	TTF2_22483619_ChIP-Seq_HELA_Human	1.61139965
51	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.60971040
52	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.49530066
53	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.48504343
54	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.46339001
55	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.45192231
56	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.44926179
57	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.44523264
58	ZNF274_21170338_ChIP-Seq_K562_Hela	1.41799755
59	CIITA_25753668_ChIP-Seq_RAJI_Human	1.39873303
60	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.38448481
61	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.35166787
62	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.34912337
63	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.33715567
64	SCL_19346495_ChIP-Seq_HPC-7_Human	1.33596576
65	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.33546444
66	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.32808290
67	MYC_22102868_ChIP-Seq_BL_Human	1.30965489
68	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.29207022
69	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.28136953
70	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.27126088
71	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.26742600
72	VDR_21846776_ChIP-Seq_THP-1_Human	1.26165388
73	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.23496982
74	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.23362651
75	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.19432365
76	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.17884990
77	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.17072489
78	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.17012749
79	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.16982886
80	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.14273915
81	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.13916868
82	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.12447615
83	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.11621046
84	TFEB_21752829_ChIP-Seq_HELA_Human	1.11539266
85	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.10599949
86	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.09696164
87	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.07945423
88	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.07148589
89	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.06720031
90	TP53_22573176_ChIP-Seq_HFKS_Human	1.06162875
91	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.05872362
92	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.03349322
93	BCL6_27268052_Chip-Seq_Bcells_Human	1.03236083
94	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.02903546
95	* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.02084440
96	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.02037629
97	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.01037687
98	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.00979253
99	KDM5A_27292631_Chip-Seq_BREAST_Human	1.00945303
100	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.00259114
101	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.99478267
102	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.98919492
103	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.98820046
104	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.98214678
105	VDR_22108803_ChIP-Seq_LS180_Human	0.96711679
106	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.95560083
107	RUNX1_22412390_ChIP-Seq_EML_Mouse	0.95293441
108	VDR_24763502_ChIP-Seq_THP-1_Human	0.95122778
109	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.94345193
110	GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.94310218
111	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.93023597
112	PU.1_20513432_ChIP-Seq_Bcells_Mouse	0.92837312
113	ERG_20517297_ChIP-Seq_VCAP_Human	0.92338375
114	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.92051592
115	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.91411319
116	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.91408904
117	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.91218637
118	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.90985879
119	* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.90832274
120	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.89334267
121	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.89061858
122	CTCF_20526341_ChIP-Seq_ESCs_Human	0.88962748
123	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.88898401
124	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.87643577
125	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.86846661
126	AR_20517297_ChIP-Seq_VCAP_Human	0.86027874
127	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.85852577
128	NANOG_20526341_ChIP-Seq_ESCs_Human	0.85719652
129	ERA_21632823_ChIP-Seq_H3396_Human	0.84349126
130	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.82084282
131	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.81819676
132	TAF2_19829295_ChIP-Seq_ESCs_Human	0.77521753
133	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.77358173
134	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.76788899

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	3.24621508
2	MP0003693_abnormal_embryo_hatching	3.20746551
3	MP0003186_abnormal_redox_activity	3.15875379
4	MP0002396_abnormal_hematopoietic_system	2.70683638
5	MP0003436_decreased_susceptibility_to	2.67477493
6	MP0002148_abnormal_hypersensitivity_rea	2.59819973
7	MP0009785_altered_susceptibility_to	2.59097120
8	MP0001905_abnormal_dopamine_level	2.57434835
9	MP0003724_increased_susceptibility_to	2.54720361
10	MP0005671_abnormal_response_to	2.54675769
11	MP0003011_delayed_dark_adaptation	2.37413935
12	MP0001529_abnormal_vocalization	2.35303001
13	MP0008875_abnormal_xenobiotic_pharmacok	2.34241421
14	MP0001853_heart_inflammation	2.33956904
15	MP0002837_dystrophic_cardiac_calcinosis	2.31824809
16	MP0002653_abnormal_ependyma_morphology	2.26832229
17	MP0003806_abnormal_nucleotide_metabolis	2.25297157
18	MP0009333_abnormal_splenocyte_physiolog	2.24847288
19	MP0003656_abnormal_erythrocyte_physiolo	2.22138548
20	MP0000685_abnormal_immune_system	2.20003480
21	MP0003136_yellow_coat_color	2.18619959
22	MP0001545_abnormal_hematopoietic_system	2.17829155
23	MP0005397_hematopoietic_system_phenotyp	2.17829155
24	MP0003763_abnormal_thymus_physiology	2.15040408
25	MP0005025_abnormal_response_to	2.11626943
26	MP0005000_abnormal_immune_tolerance	2.02313529
27	MP0006072_abnormal_retinal_apoptosis	1.98959576
28	MP0004957_abnormal_blastocyst_morpholog	1.93619789
29	MP0004808_abnormal_hematopoietic_stem	1.87593869
30	MP0002132_abnormal_respiratory_system	1.86273912
31	MP0008995_early_reproductive_senescence	1.86126606
32	MP0002419_abnormal_innate_immunity	1.85529452
33	MP0002398_abnormal_bone_marrow	1.79630353
34	MP0000490_abnormal_crypts_of	1.78034717
35	MP0002736_abnormal_nociception_after	1.77324306
36	MP0002723_abnormal_immune_serum	1.77097791
37	MP0006292_abnormal_olfactory_placode	1.76610110
38	MP0003718_maternal_effect	1.74320361
39	MP0010386_abnormal_urinary_bladder	1.73815885
40	MP0002452_abnormal_antigen_presenting	1.73412933
41	MP0008789_abnormal_olfactory_epithelium	1.73049703
42	MP0002420_abnormal_adaptive_immunity	1.71741767
43	MP0001800_abnormal_humoral_immune	1.70522656
44	MP0003077_abnormal_cell_cycle	1.70363818
45	MP0001819_abnormal_immune_cell	1.69956218
46	MP0006036_abnormal_mitochondrial_physio	1.69286082
47	MP0005464_abnormal_platelet_physiology	1.67940713
48	MP0004142_abnormal_muscle_tone	1.64125738
49	MP0002277_abnormal_respiratory_mucosa	1.60918070
50	MP0005075_abnormal_melanosome_morpholog	1.59292728
51	MP0006054_spinal_hemorrhage	1.58909720
52	MP0002405_respiratory_system_inflammati	1.58092443
53	MP0010094_abnormal_chromosome_stability	1.57356015
54	MP0000689_abnormal_spleen_morphology	1.56653263
55	MP0003195_calcinosis	1.56087540
56	MP0008058_abnormal_DNA_repair	1.54996478
57	MP0010030_abnormal_orbit_morphology	1.54446849
58	MP0000716_abnormal_immune_system	1.54045640
59	MP0002722_abnormal_immune_system	1.53721350
60	MP0002429_abnormal_blood_cell	1.53531555
61	MP0002822_catalepsy	1.52446772
62	MP0004147_increased_porphyrin_level	1.52176283
63	MP0008007_abnormal_cellular_replicative	1.47988942
64	MP0001968_abnormal_touch/_nociception	1.45394892
65	MP0005551_abnormal_eye_electrophysiolog	1.44971824
66	MP0003880_abnormal_central_pattern	1.44912013
67	MP0001845_abnormal_inflammatory_respons	1.41392631
68	MP0008469_abnormal_protein_level	1.40840071
69	MP0001533_abnormal_skeleton_physiology	1.40425075
70	MP0005645_abnormal_hypothalamus_physiol	1.39621648
71	MP0003111_abnormal_nucleus_morphology	1.39104340
72	MP0002163_abnormal_gland_morphology	1.39061984
73	MP0008872_abnormal_physiological_respon	1.36531426
74	MP0000372_irregular_coat_pigmentation	1.35700788
75	MP0005387_immune_system_phenotype	1.32018594
76	MP0001790_abnormal_immune_system	1.32018594
77	MP0005084_abnormal_gallbladder_morpholo	1.30170087
78	MP0005332_abnormal_amino_acid	1.28575048
79	MP0002638_abnormal_pupillary_reflex	1.25913908
80	MP0005253_abnormal_eye_physiology	1.25616227
81	MP0002933_joint_inflammation	1.23162193
82	MP0009697_abnormal_copulation	1.22718611
83	MP0003786_premature_aging	1.22539152
84	MP0004133_heterotaxia	1.22492334
85	MP0005646_abnormal_pituitary_gland	1.22301796
86	MP0000343_altered_response_to	1.20908985
87	MP0006276_abnormal_autonomic_nervous	1.20644269
88	MP0008932_abnormal_embryonic_tissue	1.20543924
89	MP0006082_CNS_inflammation	1.20495092
90	MP0003866_abnormal_defecation	1.19785417
91	MP0000858_altered_metastatic_potential	1.18211653
92	MP0005058_abnormal_lysosome_morphology	1.18061115
93	MP0010155_abnormal_intestine_physiology	1.16354500
94	MP0001873_stomach_inflammation	1.15814058
95	MP0001986_abnormal_taste_sensitivity	1.14981488
96	MP0002019_abnormal_tumor_incidence	1.13575807
97	MP0009379_abnormal_foot_pigmentation	1.12440738
98	MP0002166_altered_tumor_susceptibility	1.11904294
99	MP0001764_abnormal_homeostasis	1.11614080
100	MP0002102_abnormal_ear_morphology	1.09866169
101	MP0000703_abnormal_thymus_morphology	1.08592604
102	MP0000313_abnormal_cell_death	1.07771947
103	MP0005171_absent_coat_pigmentation	1.07637750
104	MP0001756_abnormal_urination	1.06224172
105	MP0009764_decreased_sensitivity_to	1.05693338
106	MP0000631_abnormal_neuroendocrine_gland	1.05369806
107	MP0002006_tumorigenesis	1.04448991
108	MP0000465_gastrointestinal_hemorrhage	1.03509734
109	MP0003943_abnormal_hepatobiliary_system	1.03460489
110	MP0004782_abnormal_surfactant_physiolog	0.96750345
111	MP0005174_abnormal_tail_pigmentation	0.96150399
112	MP0002877_abnormal_melanocyte_morpholog	0.94354408
113	MP0005410_abnormal_fertilization	0.93836570
114	MP0005319_abnormal_enzyme/_coenzyme	0.93335883
115	MP0000681_abnormal_thyroid_gland	0.91683734
116	MP0009745_abnormal_behavioral_response	0.91634306
117	MP0001984_abnormal_olfaction	0.91262100
118	MP0000358_abnormal_cell_content/	0.90848518
119	MP0000015_abnormal_ear_pigmentation	0.89054526
120	MP0009046_muscle_twitch	0.88994839
121	MP0001542_abnormal_bone_strength	0.88980940
122	MP0000516_abnormal_urinary_system	0.87929079
123	MP0005367_renal/urinary_system_phenotyp	0.87929079
124	MP0005390_skeleton_phenotype	0.85675251
125	MP0002234_abnormal_pharynx_morphology	0.85393090
126	MP0005636_abnormal_mineral_homeostasis	0.85205243
127	MP0005379_endocrine/exocrine_gland_phen	0.84931387
128	MP0003123_paternal_imprinting	0.84400380
129	MP0009840_abnormal_foam_cell	0.84060697
130	MP0005499_abnormal_olfactory_system	0.83206491
131	MP0005394_taste/olfaction_phenotype	0.83206491
132	MP0003121_genomic_imprinting	0.82606210
133	MP0002876_abnormal_thyroid_physiology	0.81151935
134	MP0003279_aneurysm	0.81044562
135	MP0000538_abnormal_urinary_bladder	0.80580656
136	MP0000598_abnormal_liver_morphology	0.80199452
137	MP0006035_abnormal_mitochondrial_morpho	0.79516487
138	MP0005584_abnormal_enzyme/coenzyme_acti	0.79497714
139	MP0000750_abnormal_muscle_regeneration	0.79183427
140	MP0002210_abnormal_sex_determination	0.78698234
141	MP0001970_abnormal_pain_threshold	0.78543729
142	MP0000749_muscle_degeneration	0.78057717
143	MP0005389_reproductive_system_phenotype	0.76820943
144	MP0002272_abnormal_nervous_system	0.76536812
145	MP0002282_abnormal_trachea_morphology	0.75942089
146	MP0004019_abnormal_vitamin_homeostasis	0.74810235
147	MP0001293_anophthalmia	0.74360268
148	MP0009643_abnormal_urine_homeostasis	0.74286415
149	MP0003638_abnormal_response/metabolism_	0.73683042
150	MP0005360_urolithiasis	0.72687293
151	MP0002693_abnormal_pancreas_physiology	0.71370980
152	MP0008877_abnormal_DNA_methylation	0.71238278
153	MP0001663_abnormal_digestive_system	0.69008296
154	MP0005377_hearing/vestibular/ear_phenot	0.68433631
155	MP0003878_abnormal_ear_physiology	0.68433631
156	MP0002095_abnormal_skin_pigmentation	0.67877160
157	MP0005423_abnormal_somatic_nervous	0.67047205
158	MP0002160_abnormal_reproductive_system	0.66886721
159	MP0001929_abnormal_gametogenesis	0.66344896
160	MP0005408_hypopigmentation	0.66062483
161	MP0000026_abnormal_inner_ear	0.66001735
162	MP0002928_abnormal_bile_duct	0.65897461
163	MP0008873_increased_physiological_sensi	0.65721662
164	MP0002938_white_spotting	0.65708216
165	MP0005083_abnormal_biliary_tract	0.64380198
166	MP0005365_abnormal_bile_salt	0.61193734
167	MP0009763_increased_sensitivity_to	0.60740358
168	MP0008057_abnormal_DNA_replication	0.60651272

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal number of erythroid precursors (HP:0012131)	4.47242211
2	Abnormality of cells of the erythroid lineage (HP:0012130)	4.42778570
3	Aplastic anemia (HP:0001915)	4.34418966
4	Type I transferrin isoform profile (HP:0003642)	3.97117440
5	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.79253275
6	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.79253275
7	Hepatic necrosis (HP:0002605)	3.48415692
8	Petechiae (HP:0000967)	3.43960784
9	Hepatocellular necrosis (HP:0001404)	3.42616801
10	Elevated erythrocyte sedimentation rate (HP:0003565)	3.40384204
11	Thrombocytosis (HP:0001894)	3.38191343
12	Mitochondrial inheritance (HP:0001427)	3.37383123
13	Reticulocytopenia (HP:0001896)	3.32873621
14	Reduced antithrombin III activity (HP:0001976)	3.27865329
15	Optic disc pallor (HP:0000543)	3.22622276
16	3-Methylglutaconic aciduria (HP:0003535)	3.17148720
17	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.13726054
18	Increased CSF lactate (HP:0002490)	3.08504142
19	Acute necrotizing encephalopathy (HP:0006965)	3.01288127
20	Poor head control (HP:0002421)	2.98465830
21	Abnormal glycosylation (HP:0012345)	2.96152919
22	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.96152919
23	Abnormal protein N-linked glycosylation (HP:0012347)	2.96152919
24	Abnormal protein glycosylation (HP:0012346)	2.96152919
25	Increased hepatocellular lipid droplets (HP:0006565)	2.96089775
26	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.89411029
27	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.88155716
28	Abnormal mitochondria in muscle tissue (HP:0008316)	2.87435770
29	Lipid accumulation in hepatocytes (HP:0006561)	2.86606861
30	Exertional dyspnea (HP:0002875)	2.84087052
31	Increased serum lactate (HP:0002151)	2.83299499
32	Generalized aminoaciduria (HP:0002909)	2.82096677
33	Increased intramyocellular lipid droplets (HP:0012240)	2.80308598
34	Congenital, generalized hypertrichosis (HP:0004540)	2.79747229
35	Renal Fanconi syndrome (HP:0001994)	2.77131182
36	Degeneration of anterior horn cells (HP:0002398)	2.71198169
37	Abnormality of the anterior horn cell (HP:0006802)	2.71198169
38	Emotional lability (HP:0000712)	2.68837730
39	IgM deficiency (HP:0002850)	2.67486973
40	Lethargy (HP:0001254)	2.65475101
41	Methylmalonic aciduria (HP:0012120)	2.61911330
42	Increased muscle lipid content (HP:0009058)	2.58882868
43	Lactic acidosis (HP:0003128)	2.56590364
44	Recurrent abscess formation (HP:0002722)	2.55259733
45	CNS demyelination (HP:0007305)	2.54214909
46	Leukodystrophy (HP:0002415)	2.51120170
47	Pallor (HP:0000980)	2.47792432
48	Acute encephalopathy (HP:0006846)	2.46498570
49	Testicular atrophy (HP:0000029)	2.46335473
50	Medial flaring of the eyebrow (HP:0010747)	2.44928117
51	Vacuolated lymphocytes (HP:0001922)	2.44818165
52	Oral leukoplakia (HP:0002745)	2.42881422
53	Recurrent bacterial skin infections (HP:0005406)	2.42749760
54	Respiratory difficulties (HP:0002880)	2.41606453
55	Pancreatic cysts (HP:0001737)	2.38563631
56	Muscle fiber atrophy (HP:0100295)	2.36666997
57	Type 2 muscle fiber atrophy (HP:0003554)	2.35409488
58	Hypothermia (HP:0002045)	2.34804383
59	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.34800795
60	Dicarboxylic aciduria (HP:0003215)	2.34800795
61	Myositis (HP:0100614)	2.32062335
62	Vertebral compression fractures (HP:0002953)	2.30349293
63	Hyperphosphaturia (HP:0003109)	2.30332045
64	Microretrognathia (HP:0000308)	2.29688028
65	Abnormality of midbrain morphology (HP:0002418)	2.26872557
66	Molar tooth sign on MRI (HP:0002419)	2.26872557
67	Pancytopenia (HP:0001876)	2.26275718
68	Nausea (HP:0002018)	2.23388460
69	Methylmalonic acidemia (HP:0002912)	2.20984945
70	X-linked dominant inheritance (HP:0001423)	2.19124067
71	True hermaphroditism (HP:0010459)	2.18944659
72	Exercise intolerance (HP:0003546)	2.18489414
73	Eczematoid dermatitis (HP:0000976)	2.16484189
74	Beaking of vertebral bodies (HP:0004568)	2.16095546
75	Progressive macrocephaly (HP:0004481)	2.15298370
76	Pancreatic fibrosis (HP:0100732)	2.15176304
77	Macrocytic anemia (HP:0001972)	2.08851241
78	Abnormality of T cell physiology (HP:0011840)	2.07944246
79	Esophageal neoplasm (HP:0100751)	2.07459946
80	Neoplasm of head and neck (HP:0012288)	2.07459946
81	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.07417514
82	Abnormal pupillary function (HP:0007686)	2.06534609
83	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.04276061
84	Respiratory failure (HP:0002878)	2.04254820
85	Rough bone trabeculation (HP:0100670)	2.03793166
86	Purpura (HP:0000979)	2.02690766
87	Neutropenia (HP:0001875)	2.00939658
88	Prolonged bleeding time (HP:0003010)	1.99456588
89	Birth length less than 3rd percentile (HP:0003561)	1.99335401
90	Optic nerve coloboma (HP:0000588)	1.97629612
91	Microvesicular hepatic steatosis (HP:0001414)	1.97583407
92	Delayed CNS myelination (HP:0002188)	1.97469323
93	Premature graying of hair (HP:0002216)	1.90907651
94	Congenital stationary night blindness (HP:0007642)	1.90412983
95	Opisthotonus (HP:0002179)	1.89151348
96	Irregular epiphyses (HP:0010582)	1.87055079
97	Increased serum pyruvate (HP:0003542)	1.86904189
98	Nephrogenic diabetes insipidus (HP:0009806)	1.86865563
99	Blindness (HP:0000618)	1.86803396
100	Hyperglycinemia (HP:0002154)	1.86147677
101	Abnormality of macrophages (HP:0004311)	1.85815483
102	Aplasia/hypoplasia of the uterus (HP:0008684)	1.85768056
103	Congenital primary aphakia (HP:0007707)	1.85587503
104	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.84596471
105	Gait imbalance (HP:0002141)	1.83303578
106	Sclerocornea (HP:0000647)	1.79989319
107	IgG deficiency (HP:0004315)	1.79656909
108	Cerebral hypomyelination (HP:0006808)	1.79548160
109	Abnormality of renal resorption (HP:0011038)	1.78765065
110	Increased serum ferritin (HP:0003281)	1.78449707
111	Abnormality of fatty-acid metabolism (HP:0004359)	1.78099079
112	Cerebral edema (HP:0002181)	1.77497265
113	Renal tubular dysfunction (HP:0000124)	1.76738735
114	Autoimmune thrombocytopenia (HP:0001973)	1.76255278
115	Epistaxis (HP:0000421)	1.75065791
116	11 pairs of ribs (HP:0000878)	1.74301744
117	Redundant skin (HP:0001582)	1.72906588
118	Nonimmune hydrops fetalis (HP:0001790)	1.72804634
119	Sparse eyelashes (HP:0000653)	1.70076576
120	Microcytic anemia (HP:0001935)	1.69922798
121	Concave nail (HP:0001598)	1.69786238
122	Mediastinal lymphadenopathy (HP:0100721)	1.69774950
123	Abnormality of T cells (HP:0002843)	1.69431608
124	Nephronophthisis (HP:0000090)	1.69019901
125	Type II lissencephaly (HP:0007260)	1.67577696
126	Glycosuria (HP:0003076)	1.67496384
127	Abnormality of urine glucose concentration (HP:0011016)	1.67496384
128	Severe visual impairment (HP:0001141)	1.67206949
129	Vomiting (HP:0002013)	1.67090636
130	Orchitis (HP:0100796)	1.66816750
131	Gliosis (HP:0002171)	1.66793039
132	Abnormal urine phosphate concentration (HP:0012599)	1.66350205
133	Recurrent gram-negative bacterial infections (HP:0005420)	1.65768209
134	Selective tooth agenesis (HP:0001592)	1.65706294
135	Hypokinesia (HP:0002375)	1.64241979
136	Biconcave vertebral bodies (HP:0004586)	1.63440111
137	Prolonged neonatal jaundice (HP:0006579)	1.62686852
138	Basal ganglia calcification (HP:0002135)	1.62635664
139	Progressive microcephaly (HP:0000253)	1.62271045
140	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.61887997
141	Lymphoma (HP:0002665)	1.61010924
142	Retinal dysplasia (HP:0007973)	1.60535239
143	Abnormality of glycolysis (HP:0004366)	1.57893063
144	Amniotic constriction ring (HP:0009775)	1.55768776
145	Abnormality of placental membranes (HP:0011409)	1.55768776

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	5.67605086
2	NME2	4.14500152
3	BUB1	3.33189624
4	PIM2	3.03739937
5	STK16	2.88946187
6	EIF2AK1	2.76977866
7	MAP4K2	2.64152345
8	BCKDK	2.34338914
9	SIK3	2.31636569
10	EIF2AK3	2.22510516
11	IRAK4	2.12237746
12	KDR	1.99506628
13	MAP3K12	1.98318514
14	NUAK1	1.97805758
15	TESK2	1.97519863
16	TXK	1.93169652
17	TESK1	1.89134193
18	ZAP70	1.87304591
19	ERN1	1.86131468
20	MAP4K1	1.83982372
21	ADRBK2	1.76216384
22	VRK1	1.75013556
23	MAP3K11	1.68379279
24	ACVR1B	1.67840175
25	MUSK	1.67173254
26	WEE1	1.58004170
27	NME1	1.56216327
28	KIT	1.51685902
29	BLK	1.49529675
30	RPS6KA4	1.47590609
31	TGFBR1	1.47255359
32	IRAK3	1.44591995
33	BRSK2	1.40832897
34	DYRK2	1.40410615
35	TBK1	1.38850672
36	CSNK1G3	1.38140106
37	GRK1	1.36111320
38	MYLK	1.31851605
39	CDK8	1.30331567
40	WNK3	1.27387755
41	ILK	1.19446773
42	TEC	1.18528825
43	BTK	1.18467437
44	ARAF	1.17944527
45	MAP2K7	1.16209866
46	TSSK6	1.13806577
47	MAP2K3	1.13246153
48	NEK9	1.12726463
49	PLK4	1.12364067
50	IKBKE	1.12121846
51	MAPKAPK3	1.08271183
52	LIMK1	1.08166395
53	JAK3	1.07775572
54	PDK2	1.07051745
55	ZAK	1.06719103
56	CSNK1G2	1.06107994
57	LRRK2	1.06034819
58	PIK3CG	1.05551964
59	TYK2	1.05042382
60	CSNK1G1	1.02260313
61	TRIM28	1.01994077
62	PHKG1	0.97608298
63	PHKG2	0.97608298
64	MAP3K14	0.97546635
65	IKBKB	0.96861703
66	DYRK3	0.96256559
67	DAPK3	0.92305264
68	ABL2	0.91679529
69	SYK	0.91511859
70	CCNB1	0.90998220
71	BRSK1	0.86776351
72	FLT3	0.84723822
73	SRPK1	0.82258704
74	CSNK1A1L	0.81937500
75	BRAF	0.81105741
76	ADRBK1	0.81096620
77	RPS6KB2	0.79723253
78	MKNK1	0.79071440
79	DAPK1	0.75619565
80	PIM1	0.75190612
81	MAPK15	0.74746141
82	IRAK1	0.74674362
83	MATK	0.74617335
84	NEK1	0.74168705
85	BMPR1B	0.74131291
86	GRK7	0.73871124
87	PRKCI	0.73307116
88	PASK	0.72817804
89	TAOK3	0.72716852
90	GRK5	0.71171043
91	PLK3	0.70320706
92	FRK	0.69734480
93	RPS6KA6	0.68165416
94	CDK7	0.66931599
95	LYN	0.65949049
96	MAPKAPK5	0.65357859
97	EPHB2	0.65308635
98	SCYL2	0.65288123
99	PINK1	0.64240962
100	MST4	0.64028967
101	ATR	0.63078595
102	EIF2AK2	0.62907097
103	INSRR	0.62682241
104	LMTK2	0.61840586
105	EPHA2	0.61074114
106	PBK	0.60390827
107	CAMKK2	0.58532486
108	TLK1	0.57848251
109	RPS6KL1	0.55590040
110	RPS6KC1	0.55590040
111	MAP3K3	0.55026498
112	AURKB	0.53738443
113	PKN1	0.51816235
114	PRKG2	0.51446472
115	MAP2K6	0.51379722
116	CSNK2A1	0.51053212
117	PAK1	0.50885132
118	PLK1	0.49289444
119	RPS6KA5	0.49264290
120	CSNK2A2	0.49001744
121	CHUK	0.48769751
122	CDC7	0.48478480
123	AURKA	0.47854814
124	STK4	0.47840780
125	TGFBR2	0.45489750
126	MAPKAPK2	0.44933768
127	MARK3	0.44931960
128	OXSR1	0.44753154
129	NLK	0.44716359
130	PAK4	0.44103335
131	MAPK13	0.44076313
132	CDK19	0.43474302
133	TAOK2	0.43255835
134	GRK6	0.42290688
135	PRKCD	0.41643577
136	EPHA3	0.41201839
137	PRKCG	0.38788811
138	PRKCE	0.38219285
139	CSF1R	0.38212072
140	MAPK4	0.36836928
141	MAP3K4	0.36345215
142	CHEK2	0.35453395
143	DAPK2	0.34962412
144	CSNK1A1	0.33462503
145	PRKCQ	0.32535328
146	PRKACA	0.31405400
147	CAMK2G	0.29589461
148	TIE1	0.29266277
149	WNK4	0.27253492

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.43178097
2	Proteasome_Homo sapiens_hsa03050	4.35658966
3	DNA replication_Homo sapiens_hsa03030	3.64861623
4	RNA polymerase_Homo sapiens_hsa03020	2.94119620
5	Protein export_Homo sapiens_hsa03060	2.87877590
6	Base excision repair_Homo sapiens_hsa03410	2.54311751
7	Mismatch repair_Homo sapiens_hsa03430	2.50718860
8	Pyrimidine metabolism_Homo sapiens_hsa00240	2.49732399
9	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.26431327
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.23923014
11	Parkinsons disease_Homo sapiens_hsa05012	2.23699698
12	Cardiac muscle contraction_Homo sapiens_hsa04260	1.98537595
13	Spliceosome_Homo sapiens_hsa03040	1.97872151
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.96910358
15	Fatty acid elongation_Homo sapiens_hsa00062	1.92760695
16	Folate biosynthesis_Homo sapiens_hsa00790	1.86572486
17	Nucleotide excision repair_Homo sapiens_hsa03420	1.78467314
18	Homologous recombination_Homo sapiens_hsa03440	1.75817027
19	Sulfur relay system_Homo sapiens_hsa04122	1.67603994
20	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.53672020
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.53310759
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.49140215
23	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.45300555
24	Huntingtons disease_Homo sapiens_hsa05016	1.45013718
25	RNA transport_Homo sapiens_hsa03013	1.35007758
26	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.33388900
27	Collecting duct acid secretion_Homo sapiens_hsa04966	1.31568090
28	Purine metabolism_Homo sapiens_hsa00230	1.24540793
29	RNA degradation_Homo sapiens_hsa03018	1.23796689
30	One carbon pool by folate_Homo sapiens_hsa00670	1.19815610
31	Alzheimers disease_Homo sapiens_hsa05010	1.18749391
32	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.18481997
33	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.17240517
34	Legionellosis_Homo sapiens_hsa05134	1.16712465
35	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.16575613
36	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.14597978
37	Asthma_Homo sapiens_hsa05310	1.09196884
38	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.07128901
39	Other glycan degradation_Homo sapiens_hsa00511	1.04915644
40	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.04233017
41	Antigen processing and presentation_Homo sapiens_hsa04612	1.03229337
42	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.03089002
43	Cell cycle_Homo sapiens_hsa04110	1.01731396
44	Allograft rejection_Homo sapiens_hsa05330	1.00393412
45	Primary immunodeficiency_Homo sapiens_hsa05340	0.96816370
46	Leishmaniasis_Homo sapiens_hsa05140	0.96756735
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.95886673
48	Galactose metabolism_Homo sapiens_hsa00052	0.95715422
49	Glutathione metabolism_Homo sapiens_hsa00480	0.93567519
50	Herpes simplex infection_Homo sapiens_hsa05168	0.92614147
51	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.91586651
52	Pentose phosphate pathway_Homo sapiens_hsa00030	0.91214313
53	Phototransduction_Homo sapiens_hsa04744	0.88836339
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.88833524
55	Shigellosis_Homo sapiens_hsa05131	0.87894504
56	Propanoate metabolism_Homo sapiens_hsa00640	0.85990019
57	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.84661344
58	Sulfur metabolism_Homo sapiens_hsa00920	0.84294992
59	Measles_Homo sapiens_hsa05162	0.84288634
60	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.83618522
61	Basal transcription factors_Homo sapiens_hsa03022	0.83228399
62	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.82878626
63	Butanoate metabolism_Homo sapiens_hsa00650	0.80657632
64	Non-homologous end-joining_Homo sapiens_hsa03450	0.80223596
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.77916129
66	Pyruvate metabolism_Homo sapiens_hsa00620	0.77082673
67	Tryptophan metabolism_Homo sapiens_hsa00380	0.76864956
68	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.76576495
69	Fanconi anemia pathway_Homo sapiens_hsa03460	0.76217028
70	p53 signaling pathway_Homo sapiens_hsa04115	0.74670982
71	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.74664365
72	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.74167109
73	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.70958572
74	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.69834897
75	Regulation of autophagy_Homo sapiens_hsa04140	0.68423491
76	Caffeine metabolism_Homo sapiens_hsa00232	0.68026610
77	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.66311851
78	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.65828096
79	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.65752964
80	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.65432789
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.64527970
82	Linoleic acid metabolism_Homo sapiens_hsa00591	0.62993748
83	Peroxisome_Homo sapiens_hsa04146	0.59957147
84	Pertussis_Homo sapiens_hsa05133	0.58145803
85	Metabolic pathways_Homo sapiens_hsa01100	0.57406502
86	Apoptosis_Homo sapiens_hsa04210	0.56922571
87	Nitrogen metabolism_Homo sapiens_hsa00910	0.56820301
88	Graft-versus-host disease_Homo sapiens_hsa05332	0.56209433
89	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.55250467
90	Selenocompound metabolism_Homo sapiens_hsa00450	0.54681637
91	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.52600579
92	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.51501515
93	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.50879521
94	Phenylalanine metabolism_Homo sapiens_hsa00360	0.50588544
95	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.50420702
96	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.49543961
97	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.49494667
98	Rheumatoid arthritis_Homo sapiens_hsa05323	0.49071565
99	Carbon metabolism_Homo sapiens_hsa01200	0.48055895
100	Influenza A_Homo sapiens_hsa05164	0.47833627
101	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.47553397
102	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.47120075
103	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.47002071
104	Lysosome_Homo sapiens_hsa04142	0.46676859
105	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.45506723
106	Phagosome_Homo sapiens_hsa04145	0.44623695
107	Steroid biosynthesis_Homo sapiens_hsa00100	0.44250853
108	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.44130547
109	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.43923635
110	Thyroid cancer_Homo sapiens_hsa05216	0.43712928
111	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.42818513
112	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.42328467
113	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.41005026
114	Malaria_Homo sapiens_hsa05144	0.40496453
115	Vibrio cholerae infection_Homo sapiens_hsa05110	0.39211340
116	Hepatitis B_Homo sapiens_hsa05161	0.39172608
117	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.37982424
118	Type I diabetes mellitus_Homo sapiens_hsa04940	0.37436050
119	Chemical carcinogenesis_Homo sapiens_hsa05204	0.36494063
120	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.36266077
121	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.36161459
122	Tyrosine metabolism_Homo sapiens_hsa00350	0.36012838
123	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.35597917
124	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.35505039
125	beta-Alanine metabolism_Homo sapiens_hsa00410	0.35320098
126	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.35016677
127	Acute myeloid leukemia_Homo sapiens_hsa05221	0.33853471
128	Tuberculosis_Homo sapiens_hsa05152	0.33535055
129	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.32343048
130	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.30694970
131	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.30589161
132	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.29844092
133	Fatty acid degradation_Homo sapiens_hsa00071	0.28881701
134	Ether lipid metabolism_Homo sapiens_hsa00565	0.28249505
135	Mineral absorption_Homo sapiens_hsa04978	0.27774986

WDR83OS

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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