WDR86

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)6.12956817
2axonemal dynein complex assembly (GO:0070286)6.06332684
3pyrimidine nucleobase catabolic process (GO:0006208)5.99023959
4DNA unwinding involved in DNA replication (GO:0006268)5.63337175
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.59915258
6cilium or flagellum-dependent cell motility (GO:0001539)4.70656417
7cilium movement (GO:0003341)4.65400771
8cell migration in hindbrain (GO:0021535)4.63805973
9epithelial cilium movement (GO:0003351)4.34886018
10nucleobase catabolic process (GO:0046113)4.34675922
11motile cilium assembly (GO:0044458)4.34196446
12regulation of gene silencing by RNA (GO:0060966)4.25280126
13regulation of posttranscriptional gene silencing (GO:0060147)4.25280126
14regulation of gene silencing by miRNA (GO:0060964)4.25280126
15viral transcription (GO:0019083)4.20303824
16ribosomal small subunit assembly (GO:0000028)4.13934667
17translational termination (GO:0006415)4.08098489
18negative regulation of DNA repair (GO:0045738)3.97649512
19maturation of SSU-rRNA (GO:0030490)3.88438078
20left/right pattern formation (GO:0060972)3.82907985
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.78590127
22planar cell polarity pathway involved in neural tube closure (GO:0090179)3.78193187
23midgut development (GO:0007494)3.74992240
24G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.69693324
25regulation of stem cell maintenance (GO:2000036)3.66997008
26notochord development (GO:0030903)3.65410705
27establishment of mitochondrion localization (GO:0051654)3.65034634
28spliceosomal tri-snRNP complex assembly (GO:0000244)3.64433551
29pre-miRNA processing (GO:0031054)3.62394146
30regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.53795394
31dendritic spine morphogenesis (GO:0060997)3.53299457
32translational elongation (GO:0006414)3.52396433
33DNA strand elongation involved in DNA replication (GO:0006271)3.51968657
34epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.44571022
35negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.43447187
36head development (GO:0060322)3.42507163
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.38216761
38regulation of heart morphogenesis (GO:2000826)3.37422574
39DNA replication initiation (GO:0006270)3.36905420
40locomotory exploration behavior (GO:0035641)3.35213163
41DNA strand elongation (GO:0022616)3.33407591
42DNA replication checkpoint (GO:0000076)3.32458921
43mesenchymal cell proliferation (GO:0010463)3.32196784
44ribosomal large subunit biogenesis (GO:0042273)3.28567423
45RNA destabilization (GO:0050779)3.28389127
46embryonic hindlimb morphogenesis (GO:0035116)3.28370473
47translational initiation (GO:0006413)3.27439624
48establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.26502151
49mitochondrion transport along microtubule (GO:0047497)3.26502151
50DNA replication-dependent nucleosome assembly (GO:0006335)3.26435455
51DNA replication-dependent nucleosome organization (GO:0034723)3.26435455
52folic acid-containing compound biosynthetic process (GO:0009396)3.24021241
53neuron recognition (GO:0008038)3.22900343
54regulation of telomere maintenance via telomerase (GO:0032210)3.19490973
55spliceosomal complex assembly (GO:0000245)3.17833050
56substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.16423146
57substrate-independent telencephalic tangential migration (GO:0021826)3.16423146
58peptidyl-arginine omega-N-methylation (GO:0035247)3.16103100
59regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.15986759
60hindlimb morphogenesis (GO:0035137)3.15477960
61regulation of glycogen (starch) synthase activity (GO:2000465)3.15265896
62regulation of synapse structural plasticity (GO:0051823)3.14844829
63polarized epithelial cell differentiation (GO:0030859)3.13994718
64positive regulation of transcription regulatory region DNA binding (GO:2000679)3.13358990
65negative regulation of RNA splicing (GO:0033119)3.13285201
66regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.13126708
67nuclear pore organization (GO:0006999)3.11961032
68mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.09611128
69hippo signaling (GO:0035329)3.09269586
70outer ear morphogenesis (GO:0042473)3.06629924
71viral life cycle (GO:0019058)3.05378323
72SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.04447896
73IMP biosynthetic process (GO:0006188)3.04215272
74cellular protein complex disassembly (GO:0043624)3.03929672
75establishment of apical/basal cell polarity (GO:0035089)3.03245543
76axonal fasciculation (GO:0007413)3.01796163
77telomere maintenance via semi-conservative replication (GO:0032201)2.99417118
78protein complex disassembly (GO:0043241)2.99061434
79semaphorin-plexin signaling pathway (GO:0071526)2.98155828
80cotranslational protein targeting to membrane (GO:0006613)2.95334907
81protein targeting to ER (GO:0045047)2.94087605
82axoneme assembly (GO:0035082)2.93674947
83heterochromatin organization (GO:0070828)2.92816425
84neuronal ion channel clustering (GO:0045161)2.92679470
85mitotic nuclear envelope disassembly (GO:0007077)2.91816705
86cell proliferation involved in metanephros development (GO:0072203)2.91707908
87negative regulation of mRNA processing (GO:0050686)2.89864360
88short-term memory (GO:0007614)2.89678056
89axon extension involved in axon guidance (GO:0048846)2.86580176
90neuron projection extension involved in neuron projection guidance (GO:1902284)2.86580176
91auditory behavior (GO:0031223)2.86328446
92spliceosomal snRNP assembly (GO:0000387)2.86099084
93DNA duplex unwinding (GO:0032508)2.83502620
94DNA geometric change (GO:0032392)2.82887373
95alternative mRNA splicing, via spliceosome (GO:0000380)2.82293236
96mitotic metaphase plate congression (GO:0007080)2.80880941
97metaphase plate congression (GO:0051310)2.80161273
98protein-DNA complex disassembly (GO:0032986)2.78303544
99nucleosome disassembly (GO:0006337)2.78303544
100regulation of helicase activity (GO:0051095)2.77854915
101cell migration involved in heart development (GO:0060973)2.77637353
102protein localization to cilium (GO:0061512)2.77255137
103nodal signaling pathway (GO:0038092)2.76981442
104lateral sprouting from an epithelium (GO:0060601)2.76530755
105macromolecular complex disassembly (GO:0032984)2.75801318
106cell surface receptor signaling pathway involved in heart development (GO:0061311)2.75713965
107regulation of cilium movement (GO:0003352)2.74581177
108formation of translation preinitiation complex (GO:0001731)2.73520295
109establishment of protein localization to endoplasmic reticulum (GO:0072599)2.73481825
110mismatch repair (GO:0006298)2.72685814
111RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.72103426
112mRNA splicing, via spliceosome (GO:0000398)2.72103426
113positive regulation of SMAD protein import into nucleus (GO:0060391)2.71814786
114histone arginine methylation (GO:0034969)2.69599884
115proximal/distal pattern formation (GO:0009954)2.68990165
116behavioral response to nicotine (GO:0035095)2.68326982
117cranial nerve morphogenesis (GO:0021602)2.67681853
118membrane disassembly (GO:0030397)2.67628157
119nuclear envelope disassembly (GO:0051081)2.67628157
120RNA splicing, via transesterification reactions (GO:0000375)2.66990375
121parturition (GO:0007567)2.65771580
122protein localization to endoplasmic reticulum (GO:0070972)2.65737608
123anterior/posterior axis specification, embryo (GO:0008595)2.65083878
124protein localization to kinetochore (GO:0034501)2.64463003
125negative regulation of chromosome segregation (GO:0051985)2.63616864
126negative regulation of catecholamine secretion (GO:0033604)2.62864990
127somite development (GO:0061053)2.62847839
128mitotic spindle assembly checkpoint (GO:0007094)2.62711233
129nuclear-transcribed mRNA catabolic process (GO:0000956)2.62488487
130exploration behavior (GO:0035640)2.62413184
131tolerance induction (GO:0002507)2.61073423
132kinetochore organization (GO:0051383)2.60748213
133negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.59203523
134negative regulation of sister chromatid segregation (GO:0033046)2.59203523
135negative regulation of mitotic sister chromatid separation (GO:2000816)2.59203523
136negative regulation of mitotic sister chromatid segregation (GO:0033048)2.59203523
137regulation of axon extension involved in axon guidance (GO:0048841)2.59071206
138layer formation in cerebral cortex (GO:0021819)2.58645442
139positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.58545047
140vocalization behavior (GO:0071625)2.58337685
141germ cell migration (GO:0008354)2.58309971
142cartilage morphogenesis (GO:0060536)2.58270093
143embryonic skeletal joint morphogenesis (GO:0060272)2.57340365
144central nervous system projection neuron axonogenesis (GO:0021952)2.56923871
145lateral ventricle development (GO:0021670)2.56853664
146adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.56524103
147neuron cell-cell adhesion (GO:0007158)2.54486215
148regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.53106835
149spinal cord association neuron differentiation (GO:0021527)2.52642282
150regulation of axon guidance (GO:1902667)2.52213004
151neuron remodeling (GO:0016322)2.51244427
152regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.50773687
153glucocorticoid biosynthetic process (GO:0006704)2.50294595
154negative regulation of amino acid transport (GO:0051956)2.48651325
155ear development (GO:0043583)2.47281060
156microtubule bundle formation (GO:0001578)2.45325236
157establishment of nucleus localization (GO:0040023)2.42443495
158cerebral cortex neuron differentiation (GO:0021895)2.41578915
159endoderm formation (GO:0001706)2.40950760
160branching involved in labyrinthine layer morphogenesis (GO:0060670)2.37968558
161regulation of microtubule-based movement (GO:0060632)2.37629217
162positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.37517548
163neurotransmitter-gated ion channel clustering (GO:0072578)2.37448995
164response to corticosterone (GO:0051412)2.37353085
165presynaptic membrane organization (GO:0097090)2.35637223
166response to prostaglandin E (GO:0034695)2.35535848
167negative regulation of amine transport (GO:0051953)2.35517291
168protein localization to synapse (GO:0035418)2.35356290
169forebrain neuron differentiation (GO:0021879)2.34315751
170nonmotile primary cilium assembly (GO:0035058)2.32052680
171respiratory system process (GO:0003016)2.31858009
172thyroid hormone generation (GO:0006590)2.31318495
173dendritic spine organization (GO:0097061)2.30483412
174lung epithelium development (GO:0060428)2.29770707
175negative regulation of translation, ncRNA-mediated (GO:0040033)2.29400590
176regulation of translation, ncRNA-mediated (GO:0045974)2.29400590
177negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.29400590
178regulation of glutamate receptor signaling pathway (GO:1900449)2.28147034
179phosphatidylglycerol biosynthetic process (GO:0006655)2.27331544
180dopamine receptor signaling pathway (GO:0007212)2.27188231
181negative regulation of catenin import into nucleus (GO:0035414)2.25567066
182negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.20988103
183retinal ganglion cell axon guidance (GO:0031290)2.20842167
184positive regulation of catecholamine secretion (GO:0033605)2.20840039
185regulation of synapse maturation (GO:0090128)2.20825299
186calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.20531493
187synaptic transmission, cholinergic (GO:0007271)2.20282059
188positive regulation of axonogenesis (GO:0050772)2.20054130
189convergent extension (GO:0060026)2.19553498
190regulation of ARF GTPase activity (GO:0032312)2.18522062
191establishment of monopolar cell polarity (GO:0061162)2.18498720
192establishment or maintenance of monopolar cell polarity (GO:0061339)2.18498720
193postsynaptic membrane organization (GO:0001941)2.16903315
194regulation of axonogenesis (GO:0050770)2.15960159
195negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.15606387
196presynaptic membrane assembly (GO:0097105)2.15284254
197positive regulation of synapse maturation (GO:0090129)2.15067021

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.23832769
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.60512791
3EZH2_22144423_ChIP-Seq_EOC_Human4.26590521
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.02433251
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.92994551
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.26566037
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.25029523
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.14993133
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.02084067
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.87436922
11DROSHA_22980978_ChIP-Seq_HELA_Human2.77170794
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.72119348
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.65371751
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.62929186
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.53144357
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.49552594
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48863067
18AR_21909140_ChIP-Seq_LNCAP_Human2.48761628
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.36524770
20XRN2_22483619_ChIP-Seq_HELA_Human2.36275250
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.32986165
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.31310179
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.31310179
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.31310179
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.28404168
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24602306
27JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19225509
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.19104847
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.18776537
30IKZF1_21737484_ChIP-ChIP_HCT116_Human2.18709789
31* KDM2B_26808549_Chip-Seq_K562_Human2.11034146
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.08889485
33RNF2_18974828_ChIP-Seq_MESCs_Mouse2.07292009
34EZH2_18974828_ChIP-Seq_MESCs_Mouse2.07292009
35NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06292030
36KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.06224985
37EZH2_27304074_Chip-Seq_ESCs_Mouse2.04559978
38EGR1_19374776_ChIP-ChIP_THP-1_Human2.03923093
39ERG_21242973_ChIP-ChIP_JURKAT_Human2.02748709
40* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.01553221
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.01166672
42EED_16625203_ChIP-ChIP_MESCs_Mouse2.00266843
43TCF3_18692474_ChIP-Seq_MEFs_Mouse1.99719164
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.96590004
45MYC_22102868_ChIP-Seq_BL_Human1.93075295
46CTCF_27219007_Chip-Seq_Bcells_Human1.90538914
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.89524098
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.85948394
49* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85432561
50SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.81824559
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.81601371
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.80221912
53SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.75075657
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.74959893
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.73306661
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.69317995
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.67849568
58REST_21632747_ChIP-Seq_MESCs_Mouse1.67507205
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.66151172
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.64958014
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.64920693
62LXR_22292898_ChIP-Seq_THP-1_Human1.64228675
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.64149032
64CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62702008
65* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62585393
66E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62129000
67ETS1_20019798_ChIP-Seq_JURKAT_Human1.61734062
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59231749
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59091876
70KDM2B_26808549_Chip-Seq_DND41_Human1.57504510
71VDR_21846776_ChIP-Seq_THP-1_Human1.56723722
72KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54892330
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54272116
74SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.53516520
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53474389
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53305739
77NANOG_21062744_ChIP-ChIP_HESCs_Human1.51533707
78RING1B_27294783_Chip-Seq_ESCs_Mouse1.51110691
79* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49090766
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46803763
81OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.46660990
82HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42944850
83STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42828246
84ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41594783
85TTF2_22483619_ChIP-Seq_HELA_Human1.41472017
86CIITA_25753668_ChIP-Seq_RAJI_Human1.41242972
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40820411
88TCF3_18692474_ChIP-Seq_MESCs_Mouse1.39493274
89REST_18959480_ChIP-ChIP_MESCs_Mouse1.38987180
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35361301
91SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.35075436
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33852502
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32662039
94* P68_20966046_ChIP-Seq_HELA_Human1.32549160
95TP53_20018659_ChIP-ChIP_R1E_Mouse1.31885482
96ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.31343590
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.31115431
98KDM2B_26808549_Chip-Seq_JURKAT_Human1.30975338
99MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30587225
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29384382
101RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.26953201
102ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26094987
103KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.25624771
104SMC4_20622854_ChIP-Seq_HELA_Human1.23754653
105DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21659227
106SOX2_18692474_ChIP-Seq_MEFs_Mouse1.20882590
107SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19174983
108CBX2_27304074_Chip-Seq_ESCs_Mouse1.18002586
109MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.16868067
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16582975
111KDM5A_27292631_Chip-Seq_BREAST_Human1.16376212
112* RARB_27405468_Chip-Seq_BRAIN_Mouse1.16286311
113RING1B_27294783_Chip-Seq_NPCs_Mouse1.15974098
114* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15677824
115OCT4_18692474_ChIP-Seq_MEFs_Mouse1.15509134
116MYC_18940864_ChIP-ChIP_HL60_Human1.14500781
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14016466
118NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.13830394
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12473050
120GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10529503
121WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10323352
122SA1_27219007_Chip-Seq_ERYTHROID_Human1.10168944
123MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.09810111
124ISL1_27105846_Chip-Seq_CPCs_Mouse1.09108174
125RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08941294
126SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08820116
127* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08817462
128VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07777089
129DCP1A_22483619_ChIP-Seq_HELA_Human1.07559979
130SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07447877
131TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04694147
132OCT4_19829295_ChIP-Seq_ESCs_Human1.03935569
133NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03825008
134ESR2_21235772_ChIP-Seq_MCF-7_Human1.02691101
135STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02657163
136TCF7_22412390_ChIP-Seq_EML_Mouse1.01435404
137ELK3_25401928_ChIP-Seq_HUVEC_Human1.01247485
138GABP_19822575_ChIP-Seq_HepG2_Human1.00908651
139YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00701672
140ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00689483
141CREB1_26743006_Chip-Seq_LNCaP_Human0.99469755
142EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99158856
143ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98941712
144ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98767325
145RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98713088
146VDR_23849224_ChIP-Seq_CD4+_Human0.98707949
147TET1_21451524_ChIP-Seq_MESCs_Mouse0.97597444
148ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97168341
149GATA1_26923725_Chip-Seq_HPCs_Mouse0.97098361
150RNF2_27304074_Chip-Seq_NSC_Mouse0.96806431
151TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96583687
152NANOG_16153702_ChIP-ChIP_HESCs_Human0.96083333
153POU5F1_16518401_ChIP-PET_MESCs_Mouse0.95788603
154* BCL6_27268052_Chip-Seq_Bcells_Human0.95268949
155SA1_27219007_Chip-Seq_Bcells_Human0.94845677
156NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94441342
157NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93287724
158SOX2_16153702_ChIP-ChIP_HESCs_Human0.92421502
159DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91900842
160BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91743006
161THAP11_20581084_ChIP-Seq_MESCs_Mouse0.91156487
162SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91134399
163KLF4_19829295_ChIP-Seq_ESCs_Human0.91068610
164NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.90937097
165TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90792307
166STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90300842
167FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88728534
168SOX2_18692474_ChIP-Seq_MESCs_Mouse0.88616481
169KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87758195
170ELF1_20517297_ChIP-Seq_JURKAT_Human0.87681789
171CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87402706
172AR_21572438_ChIP-Seq_LNCaP_Human0.87234918
173POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87000125
174TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87000125
175UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86912794
176GABP_17652178_ChIP-ChIP_JURKAT_Human0.86523508
177STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86019154
178SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85530622
179TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.84337558
180TP63_22573176_ChIP-Seq_HFKS_Human0.83813288
181NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83649010
182SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.83243292
183SOX3_22085726_ChIP-Seq_NPCs_Mouse0.82759476
184CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82649504
185CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.80757952
186SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.80449962

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy4.20279977
2MP0010030_abnormal_orbit_morphology3.96538852
3MP0003123_paternal_imprinting3.92521973
4MP0003880_abnormal_central_pattern3.26989562
5MP0009053_abnormal_anal_canal2.92453002
6MP0001984_abnormal_olfaction2.90632422
7MP0005377_hearing/vestibular/ear_phenot2.76373103
8MP0003878_abnormal_ear_physiology2.76373103
9MP0003122_maternal_imprinting2.67063443
10MP0000537_abnormal_urethra_morphology2.60839440
11MP0003385_abnormal_body_wall2.60311246
12MP0003787_abnormal_imprinting2.59957576
13MP0004859_abnormal_synaptic_plasticity2.59088082
14MP0006276_abnormal_autonomic_nervous2.56707490
15MP0010094_abnormal_chromosome_stability2.55905512
16MP0000778_abnormal_nervous_system2.53670134
17MP0003941_abnormal_skin_development2.50740372
18MP0003724_increased_susceptibility_to2.42962337
19MP0003329_amyloid_beta_deposits2.41785572
20MP0002249_abnormal_larynx_morphology2.28618910
21MP0003942_abnormal_urinary_system2.13075130
22MP0000049_abnormal_middle_ear2.07895509
23MP0003111_abnormal_nucleus_morphology2.05316552
24MP0008057_abnormal_DNA_replication2.01404119
25MP0003077_abnormal_cell_cycle2.00474612
26MP0001293_anophthalmia2.00396339
27MP0004957_abnormal_blastocyst_morpholog1.98899169
28MP0005394_taste/olfaction_phenotype1.97625318
29MP0005499_abnormal_olfactory_system1.97625318
30MP0009384_cardiac_valve_regurgitation1.97247849
31MP0003693_abnormal_embryo_hatching1.94558785
32MP0009250_abnormal_appendicular_skeleto1.93143248
33MP0000428_abnormal_craniofacial_morphol1.92704058
34MP0005423_abnormal_somatic_nervous1.90757276
35MP0003121_genomic_imprinting1.90655322
36MP0003937_abnormal_limbs/digits/tail_de1.89509289
37MP0003119_abnormal_digestive_system1.85629217
38MP0004130_abnormal_muscle_cell1.80294069
39MP0003705_abnormal_hypodermis_morpholog1.77027069
40MP0001188_hyperpigmentation1.65809292
41MP0002653_abnormal_ependyma_morphology1.65294419
42MP0003567_abnormal_fetal_cardiomyocyte1.64386258
43MP0004885_abnormal_endolymph1.63754518
44MP0003011_delayed_dark_adaptation1.63709354
45MP0003935_abnormal_craniofacial_develop1.63408059
46MP0002282_abnormal_trachea_morphology1.62614275
47MP0002085_abnormal_embryonic_tissue1.62289619
48MP0002063_abnormal_learning/memory/cond1.62120945
49MP0008007_abnormal_cellular_replicative1.61935800
50MP0004197_abnormal_fetal_growth/weight/1.60222638
51MP0002932_abnormal_joint_morphology1.59401924
52MP0000350_abnormal_cell_proliferation1.58326591
53MP0000955_abnormal_spinal_cord1.57143902
54MP0003635_abnormal_synaptic_transmissio1.56444725
55MP0002938_white_spotting1.54931618
56MP0005503_abnormal_tendon_morphology1.54328404
57MP0008932_abnormal_embryonic_tissue1.54301159
58MP0003279_aneurysm1.50905530
59MP0002102_abnormal_ear_morphology1.49940638
60MP0002233_abnormal_nose_morphology1.49166774
61MP0008789_abnormal_olfactory_epithelium1.49137580
62MP0004858_abnormal_nervous_system1.48964478
63MP0001697_abnormal_embryo_size1.48736045
64MP0005380_embryogenesis_phenotype1.47384131
65MP0001672_abnormal_embryogenesis/_devel1.47384131
66MP0003879_abnormal_hair_cell1.46883099
67MP0002084_abnormal_developmental_patter1.46628984
68MP0002638_abnormal_pupillary_reflex1.46125318
69MP0004742_abnormal_vestibular_system1.45697057
70MP0001502_abnormal_circadian_rhythm1.43142850
71MP0009672_abnormal_birth_weight1.42282099
72MP0005187_abnormal_penis_morphology1.39525557
73MP0003806_abnormal_nucleotide_metabolis1.39143460
74MP0004272_abnormal_basement_membrane1.37556708
75MP0000762_abnormal_tongue_morphology1.37542522
76MP0009278_abnormal_bone_marrow1.37335147
77MP0000534_abnormal_ureter_morphology1.36247584
78MP0001730_embryonic_growth_arrest1.35924691
79MP0002572_abnormal_emotion/affect_behav1.35836290
80MP0003755_abnormal_palate_morphology1.35472404
81MP0002933_joint_inflammation1.35294971
82MP0002088_abnormal_embryonic_growth/wei1.34881481
83MP0003984_embryonic_growth_retardation1.34615914
84MP0002111_abnormal_tail_morphology1.34364629
85MP0000681_abnormal_thyroid_gland1.32850727
86MP0005076_abnormal_cell_differentiation1.32670984
87MP0003890_abnormal_embryonic-extraembry1.32133532
88MP0002086_abnormal_extraembryonic_tissu1.30440510
89MP0003315_abnormal_perineum_morphology1.29889946
90MP0005670_abnormal_white_adipose1.29467777
91MP0008058_abnormal_DNA_repair1.28916873
92MP0002116_abnormal_craniofacial_bone1.27906888
93MP0009703_decreased_birth_body1.27803719
94MP0010352_gastrointestinal_tract_polyps1.25886952
95MP0001879_abnormal_lymphatic_vessel1.24733548
96MP0000432_abnormal_head_morphology1.24016729
97MP0003115_abnormal_respiratory_system1.23668772
98MP0001286_abnormal_eye_development1.23452775
99MP0002557_abnormal_social/conspecific_i1.21412012
100MP0000566_synostosis1.19720875
101MP0010368_abnormal_lymphatic_system1.18817766
102MP0003938_abnormal_ear_development1.16610119
103MP0005623_abnormal_meninges_morphology1.16036505
104MP0002109_abnormal_limb_morphology1.15510244
105MP0002882_abnormal_neuron_morphology1.14792328
106MP0001915_intracranial_hemorrhage1.13546529
107MP0001970_abnormal_pain_threshold1.13473542
108MP0002092_abnormal_eye_morphology1.10161504
109MP0002752_abnormal_somatic_nervous1.10079849
110MP0000604_amyloidosis1.09717458
111MP0000767_abnormal_smooth_muscle1.08928238
112MP0002876_abnormal_thyroid_physiology1.08475488
113MP0002734_abnormal_mechanical_nocicepti1.08415551
114MP0000678_abnormal_parathyroid_gland1.08128448
115MP0000026_abnormal_inner_ear1.08017301
116MP0004811_abnormal_neuron_physiology1.07535968
117MP0002184_abnormal_innervation1.07344186
118MP0002080_prenatal_lethality1.06630749
119MP0002735_abnormal_chemical_nociception1.06250380
120MP0003303_peritoneal_inflammation1.06113173
121MP0001486_abnormal_startle_reflex1.05757988
122MP0001849_ear_inflammation1.04033024
123MP0000613_abnormal_salivary_gland1.02855026
124MP0001270_distended_abdomen1.02814727
125MP0002733_abnormal_thermal_nociception0.99466426
126MP0002152_abnormal_brain_morphology0.99065486
127MP0008438_abnormal_cutaneous_collagen0.97817407
128MP0001986_abnormal_taste_sensitivity0.97506392
129MP0002272_abnormal_nervous_system0.96688439
130MP0002114_abnormal_axial_skeleton0.95224770
131MP0002089_abnormal_postnatal_growth/wei0.94293114
132MP0005508_abnormal_skeleton_morphology0.94267922
133MP0001501_abnormal_sleep_pattern0.93946581
134MP0002697_abnormal_eye_size0.92717737
135MP0003283_abnormal_digestive_organ0.92001418
136MP0002925_abnormal_cardiovascular_devel0.91683018
137MP0002254_reproductive_system_inflammat0.91620004
138MP0004270_analgesia0.90615238
139MP0001919_abnormal_reproductive_system0.87072211
140MP0004133_heterotaxia0.86107960
141MP0001968_abnormal_touch/_nociception0.85980040
142MP0006054_spinal_hemorrhage0.85197686
143MP0000163_abnormal_cartilage_morphology0.84956669
144MP0002177_abnormal_outer_ear0.84734992
145MP0002064_seizures0.83002113
146MP0000516_abnormal_urinary_system0.82576269
147MP0005367_renal/urinary_system_phenotyp0.82576269
148MP0005666_abnormal_adipose_tissue0.82545769
149MP0004019_abnormal_vitamin_homeostasis0.82281261
150MP0003943_abnormal_hepatobiliary_system0.82197680
151MP0005167_abnormal_blood-brain_barrier0.81620826
152MP0002127_abnormal_cardiovascular_syste0.81061246
153MP0003948_abnormal_gas_homeostasis0.80172627
154MP0002115_abnormal_skeleton_extremities0.80072294
155MP0000465_gastrointestinal_hemorrhage0.79779504
156MP0008995_early_reproductive_senescence0.79438998
157MP0005248_abnormal_Harderian_gland0.79328221
158MP0009745_abnormal_behavioral_response0.76870001
159MP0000266_abnormal_heart_morphology0.76614342
160MP0005375_adipose_tissue_phenotype0.76517753
161MP0003861_abnormal_nervous_system0.76057241
162MP0002128_abnormal_blood_circulation0.75797045
163MP0005671_abnormal_response_to0.74923215
164MP0001340_abnormal_eyelid_morphology0.74018516
165MP0003436_decreased_susceptibility_to0.73388993
166MP0005397_hematopoietic_system_phenotyp0.72620121
167MP0001545_abnormal_hematopoietic_system0.72620121
168MP0002751_abnormal_autonomic_nervous0.72490558
169MP0005195_abnormal_posterior_eye0.69190860
170MP0005253_abnormal_eye_physiology0.69163033
171MP0009379_abnormal_foot_pigmentation0.68568905
172MP0003690_abnormal_glial_cell0.68560705
173MP0001346_abnormal_lacrimal_gland0.67422730
174MP0004924_abnormal_behavior0.66278808
175MP0005386_behavior/neurological_phenoty0.66278808
176MP0001963_abnormal_hearing_physiology0.63723321
177MP0001440_abnormal_grooming_behavior0.60166738
178MP0004510_myositis0.60065178
179MP0005448_abnormal_energy_balance0.59792708

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.16971017
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.42431716
3Absent/shortened dynein arms (HP:0200106)6.42431716
4Abnormal respiratory epithelium morphology (HP:0012253)5.71808382
5Abnormal respiratory motile cilium morphology (HP:0005938)5.71808382
6Abnormal respiratory motile cilium physiology (HP:0012261)5.25111227
7Abnormal ciliary motility (HP:0012262)5.09945494
8Rhinitis (HP:0012384)4.94355055
9Chronic bronchitis (HP:0004469)4.34107195
10Short 4th metacarpal (HP:0010044)4.33329184
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.33329184
12Renal duplication (HP:0000075)4.10304817
13Broad metatarsal (HP:0001783)3.83381706
14Polyphagia (HP:0002591)3.81993274
15Abnormality of the 4th metacarpal (HP:0010012)3.71892404
16Mesomelia (HP:0003027)3.61833675
17Vitreoretinal degeneration (HP:0000655)3.60925133
18Nasal polyposis (HP:0100582)3.59882298
19Broad toe (HP:0001837)3.34426732
20Colon cancer (HP:0003003)3.18717970
21Reticulocytopenia (HP:0001896)3.18104871
22Abnormality of the nasal mucosa (HP:0000433)3.17386794
23Turricephaly (HP:0000262)3.11695761
24Diastasis recti (HP:0001540)3.05273383
25Thyroid-stimulating hormone excess (HP:0002925)3.05260385
26Selective tooth agenesis (HP:0001592)3.03079939
27Bronchiectasis (HP:0002110)2.94038161
28Shallow orbits (HP:0000586)2.88282146
29Supernumerary ribs (HP:0005815)2.86468510
30Midline defect of the nose (HP:0004122)2.81836188
31Broad hallux (HP:0010055)2.79221453
32Meckel diverticulum (HP:0002245)2.77775066
33Occipital encephalocele (HP:0002085)2.75344792
34Ectopic kidney (HP:0000086)2.73607647
35Supernumerary bones of the axial skeleton (HP:0009144)2.72033328
36Abnormality of the parietal bone (HP:0002696)2.68054352
37Hepatoblastoma (HP:0002884)2.66313298
38Abnormality of the ileum (HP:0001549)2.64942407
39Renovascular hypertension (HP:0100817)2.62918265
40Papilledema (HP:0001085)2.61176690
41Sleep apnea (HP:0010535)2.58501951
42Abnormal lung lobation (HP:0002101)2.58480145
43Concave nail (HP:0001598)2.56398020
44Supranuclear gaze palsy (HP:0000605)2.56216804
45Coronal craniosynostosis (HP:0004440)2.55691626
46Abnormality of the phalanges of the hallux (HP:0010057)2.55222576
47Broad thumb (HP:0011304)2.52825325
48Obstructive sleep apnea (HP:0002870)2.50158297
49Broad finger (HP:0001500)2.48190252
50Aplasia/Hypoplasia of the patella (HP:0006498)2.45101624
51Syringomyelia (HP:0003396)2.44676838
52Spinal cord lesions (HP:0100561)2.44676838
53Vertebral arch anomaly (HP:0008438)2.40897199
54Medulloblastoma (HP:0002885)2.40892826
55Atresia of the external auditory canal (HP:0000413)2.38713600
56Failure to thrive in infancy (HP:0001531)2.35970507
57Shawl scrotum (HP:0000049)2.35481160
58Short 5th finger (HP:0009237)2.33717030
59Patellar aplasia (HP:0006443)2.32567232
60Partial duplication of the phalanx of hand (HP:0009999)2.31197534
61Increased nuchal translucency (HP:0010880)2.30973474
62Nephroblastoma (Wilms tumor) (HP:0002667)2.30497471
63Broad phalanx (HP:0006009)2.30014271
64Long toe (HP:0010511)2.29451178
65Recurrent sinusitis (HP:0011108)2.29091642
66Abnormality of pyrimidine metabolism (HP:0004353)2.27889981
67Gait imbalance (HP:0002141)2.26813195
68Cortical dysplasia (HP:0002539)2.26676723
69Pseudobulbar signs (HP:0002200)2.23244555
70Abnormal number of incisors (HP:0011064)2.22205113
71Protrusio acetabuli (HP:0003179)2.21633803
72Short middle phalanx of the 5th finger (HP:0004220)2.21078163
73Broad long bones (HP:0005622)2.20926721
74Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.19451523
75Hypoplasia of the brainstem (HP:0002365)2.14776306
76Aplasia/Hypoplasia of the brainstem (HP:0007362)2.14776306
77Metaphyseal cupping (HP:0003021)2.13064676
78Neoplasm of the heart (HP:0100544)2.12403319
79Embryonal renal neoplasm (HP:0011794)2.12342524
80Chronic hepatic failure (HP:0100626)2.11847192
81Myokymia (HP:0002411)2.11693847
82Limb dystonia (HP:0002451)2.11357789
83Supernumerary spleens (HP:0009799)2.10805502
84Radial bowing (HP:0002986)2.09306009
85Broad phalanges of the hand (HP:0009768)2.08474572
86Rhabdomyosarcoma (HP:0002859)2.07796664
87Breast hypoplasia (HP:0003187)2.03587476
88Anophthalmia (HP:0000528)2.03188947
89Nephronophthisis (HP:0000090)2.03079110
90Hypoplasia of the radius (HP:0002984)2.02676437
91Delayed CNS myelination (HP:0002188)2.01731317
92Carpal synostosis (HP:0009702)2.01066966
93Atelectasis (HP:0100750)2.00371495
94Molar tooth sign on MRI (HP:0002419)1.98682505
95Abnormality of midbrain morphology (HP:0002418)1.98682505
96Osteomalacia (HP:0002749)1.97440783
97Abnormal eating behavior (HP:0100738)1.96200741
98Elevated erythrocyte sedimentation rate (HP:0003565)1.94739369
99Asymmetry of the thorax (HP:0001555)1.94628205
100Aplasia/hypoplasia of the humerus (HP:0006507)1.93761944
101Vaginal atresia (HP:0000148)1.91924404
102Pachygyria (HP:0001302)1.91540216
103Agitation (HP:0000713)1.91372796
104Abdominal situs inversus (HP:0003363)1.90751383
105Abnormality of abdominal situs (HP:0011620)1.90751383
106Abnormality of the aortic arch (HP:0012303)1.90735046
107Genital tract atresia (HP:0001827)1.90588467
108Sprengel anomaly (HP:0000912)1.89632060
109Renal dysplasia (HP:0000110)1.88522977
110Myositis (HP:0100614)1.87555231
111Trigonocephaly (HP:0000243)1.86833762
112Bronchitis (HP:0012387)1.86548480
113Retrobulbar optic neuritis (HP:0100654)1.86488500
114Optic neuritis (HP:0100653)1.86488500
115Bowing of the arm (HP:0006488)1.86368481
116Bowed forearm bones (HP:0003956)1.86368481
117Orchitis (HP:0100796)1.84279200
118Cutaneous finger syndactyly (HP:0010554)1.84191169
119Tracheoesophageal fistula (HP:0002575)1.84042399
120Bicornuate uterus (HP:0000813)1.83870828
121Bilateral microphthalmos (HP:0007633)1.82963865
122Oral leukoplakia (HP:0002745)1.82952335
123Congenital primary aphakia (HP:0007707)1.81974708
124High anterior hairline (HP:0009890)1.81679169
125Skin tags (HP:0010609)1.79754049
126Preauricular skin tag (HP:0000384)1.79684418
127Absent radius (HP:0003974)1.79642300
128Rectal prolapse (HP:0002035)1.79055651
129Chromosomal breakage induced by crosslinking agents (HP:0003221)1.77862578
130Annular pancreas (HP:0001734)1.77165361
131Neoplasm of striated muscle (HP:0009728)1.76870024
132Chin dimple (HP:0010751)1.76651367
133Ependymoma (HP:0002888)1.76004054
134Recurrent otitis media (HP:0000403)1.74896948
135Anencephaly (HP:0002323)1.74505090
136Aplasia/Hypoplasia of the spleen (HP:0010451)1.74359824
137Anosmia (HP:0000458)1.73933428
138Absent forearm bone (HP:0003953)1.72373760
139Aplasia involving forearm bones (HP:0009822)1.72373760
140Growth hormone excess (HP:0000845)1.71752447
141Preaxial foot polydactyly (HP:0001841)1.71684307
142Abnormal pancreas size (HP:0012094)1.71669165
143Camptodactyly of toe (HP:0001836)1.71289063
144Limited elbow extension (HP:0001377)1.68692858
145Duodenal stenosis (HP:0100867)1.68599484
146Small intestinal stenosis (HP:0012848)1.68599484
147Amblyopia (HP:0000646)1.68366792
148Abnormality of the phalanges of the 2nd finger (HP:0009541)1.67788509
149Hyperacusis (HP:0010780)1.66973789
150Cystic liver disease (HP:0006706)1.66834718
151Severe Myopia (HP:0011003)1.66362680
152Abnormality of the fingertips (HP:0001211)1.66353429
153Hyperglycinemia (HP:0002154)1.66006365
154Abnormality of the diencephalon (HP:0010662)1.65810786
155Cutaneous syndactyly (HP:0012725)1.65403120
156Medial flaring of the eyebrow (HP:0010747)1.64990019
157Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.64965771
158Triphalangeal thumb (HP:0001199)1.64866604
159Skull defect (HP:0001362)1.64847843
160Lymphangioma (HP:0100764)1.64388729
161Peripheral hypomyelination (HP:0007182)1.63951552
162Long foot (HP:0001833)1.63863507
163Abnormality of the lower motor neuron (HP:0002366)1.63488656
164Infertility (HP:0000789)1.63476217
165Hypoventilation (HP:0002791)1.63358884
166Pancreatic fibrosis (HP:0100732)1.63265532
167Rib fusion (HP:0000902)1.62973705
168Narrow forehead (HP:0000341)1.60884367
169Deviation of the hallux (HP:0010051)1.60875263
170Intestinal polyp (HP:0005266)1.60824190
171Cervical subluxation (HP:0003308)1.59581379
172Nephrogenic diabetes insipidus (HP:0009806)1.59396392
173Abnormality of the pubic bones (HP:0003172)1.59359831
174Morphological abnormality of the middle ear (HP:0008609)1.58411764
175Anomalous pulmonary venous return (HP:0010772)1.57259556
176Aplasia/Hypoplasia of the lens (HP:0008063)1.55562826
177Amyotrophic lateral sclerosis (HP:0007354)1.55343134
178Poor coordination (HP:0002370)1.54767702
179Bronchomalacia (HP:0002780)1.53944453
180Broad-based gait (HP:0002136)1.51388269
181Progressive cerebellar ataxia (HP:0002073)1.51227933
182Broad foot (HP:0001769)1.50884246
183Pancreatic cysts (HP:0001737)1.50477649
184Myelomeningocele (HP:0002475)1.49880240
185Torticollis (HP:0000473)1.48044656
186Postaxial hand polydactyly (HP:0001162)1.46670486
187True hermaphroditism (HP:0010459)1.46060377
188Excessive salivation (HP:0003781)1.45725340
189Epiphyseal dysplasia (HP:0002656)1.45321962

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.31287376
2LATS14.43608225
3TLK13.65339154
4CDC73.43576515
5MARK13.21692634
6BUB12.88556051
7LATS22.81974869
8CDK122.73507295
9MAP3K102.59225595
10SRPK12.54785895
11SIK22.53200629
12WEE12.39174137
13MARK21.95908970
14MAP3K41.94584071
15FLT31.91762019
16MKNK11.85859205
17PDGFRA1.83758634
18NTRK31.83672837
19TTK1.83136115
20CASK1.79613597
21PTK61.77686485
22NEK21.75447457
23MAP2K71.75318464
24EPHB11.72469988
25TYRO31.71130382
26TSSK61.69293006
27PKN21.68985277
28FES1.68066564
29CDK71.67825538
30DDR21.65425877
31MAP3K61.62629618
32RPS6KA21.58701378
33BCR1.58244313
34ATR1.56670988
35STK38L1.48374256
36EPHB21.47304781
37MAP2K21.45048872
38MAP3K81.43428037
39MKNK21.43274505
40NTRK21.42346418
41PASK1.41756953
42PLK11.40788381
43MELK1.40522299
44NEK91.40290170
45TGFBR11.33789074
46IKBKE1.32344444
47PAK41.31633917
48CDK41.31357065
49LRRK21.30908250
50BLK1.29167594
51RIPK11.28996890
52RPS6KB21.28874104
53VRK11.28857926
54EPHA31.28461819
55BRD41.25265120
56SIK31.23790582
57MATK1.21319348
58PLK41.18888114
59CHEK21.14745905
60TXK1.14533604
61CDK81.13169835
62AURKB1.11664454
63FGFR11.11206089
64NTRK11.09673610
65KDR1.09608521
66TNK21.08902638
67RPS6KA41.08377153
68ERBB21.07417148
69RPS6KC11.03191368
70RPS6KL11.03191368
71TBK11.02204952
72STK31.00180902
73CSK0.96941871
74SGK2230.96135857
75SGK4940.96135857
76CAMKK10.95375387
77RPS6KA60.95070424
78MAPK40.94657338
79PLK30.93963727
80STK110.90956400
81CDK190.86405531
82MAP3K70.86245086
83CDK20.85193114
84MTOR0.85132515
85ATM0.85021255
86MINK10.83460049
87PAK20.82515607
88MAP2K40.82370757
89CSF1R0.82349511
90DYRK1A0.81926623
91CHEK10.80516363
92MAP4K10.80508225
93RET0.78891820
94TYK20.77384528
95STK100.77231492
96EPHA40.75317030
97ABL20.75132568
98CAMK10.74507978
99CDK60.73938643
100PINK10.73758756
101CDK50.73314992
102NEK10.70722031
103DAPK20.68884993
104TRIB30.68556339
105PKN10.67779299
106TESK20.67431259
107DYRK30.67408103
108STK40.67245236
109DAPK30.65704227
110TIE10.65526418
111CSNK1G10.64775292
112UHMK10.64020065
113PRKD20.63968465
114BCKDK0.63862434
115TTN0.63525394
116CSNK1E0.63464213
117ACVR1B0.62841499
118MAPK130.62018801
119FGFR40.61923270
120DYRK1B0.61391689
121AURKA0.61146350
122KIT0.60963501
123SGK20.60941244
124MYLK0.60507497
125MAP3K110.60037394
126FYN0.59976665
127MAPK70.59511592
128PRKCZ0.57901764
129HCK0.57885848
130CDK10.57698853
131CAMK40.57503523
132TAOK10.57381011
133CDC42BPA0.55921745
134ILK0.55062153
135CSNK2A10.54051082
136LCK0.53600948
137NUAK10.53399209
138PRKD10.53103100
139PRKCG0.52217847
140MAPK30.52170712
141PRKAA10.52134577
142RPS6KA50.51734141
143PRKDC0.51479518
144WNK30.51258772
145CSNK1G20.50846558
146CSNK2A20.49605256
147MET0.48974704
148SIK10.48697888
149IKBKB0.47633274
150CAMK1D0.47517657
151DYRK20.47340133
152SGK30.46044922
153GRK60.45982252
154PRKCH0.45700793
155AKT30.44494891
156TAOK20.44240469
157DMPK0.44051696
158MAPK80.44048952
159CSNK1G30.43703598
160BMX0.42858009
161BTK0.42243676
162AKT10.41959228
163MAP3K140.41807892
164PRKAA20.41744355
165CAMK1G0.41588797
166RPS6KA10.41305469
167CSNK1A1L0.40964485
168TGFBR20.40814060
169TESK10.40773867
170INSRR0.39903246
171CSNK1D0.39432565
172HIPK20.38663872
173FGFR20.38513715
174ICK0.37934295
175CHUK0.35971681
176MAPK10.35260889
177EIF2AK10.33119717
178CCNB10.32675940

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.28046045
2Mismatch repair_Homo sapiens_hsa034303.80432839
3Spliceosome_Homo sapiens_hsa030403.72044431
4Ribosome_Homo sapiens_hsa030103.70073397
5One carbon pool by folate_Homo sapiens_hsa006703.11250905
6Axon guidance_Homo sapiens_hsa043602.65316690
7Basal cell carcinoma_Homo sapiens_hsa052172.63092984
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.52813397
9Homologous recombination_Homo sapiens_hsa034402.52453144
10Cell cycle_Homo sapiens_hsa041102.42329024
11RNA transport_Homo sapiens_hsa030132.33358718
12Base excision repair_Homo sapiens_hsa034102.29288642
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.05529107
14Fanconi anemia pathway_Homo sapiens_hsa034602.04425004
15RNA polymerase_Homo sapiens_hsa030202.02161790
16Nucleotide excision repair_Homo sapiens_hsa034202.01115709
17Hedgehog signaling pathway_Homo sapiens_hsa043401.86237293
18Hippo signaling pathway_Homo sapiens_hsa043901.84938804
19Nicotine addiction_Homo sapiens_hsa050331.84678977
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.75234681
21Selenocompound metabolism_Homo sapiens_hsa004501.62710681
22Morphine addiction_Homo sapiens_hsa050321.57858033
23Pyrimidine metabolism_Homo sapiens_hsa002401.57834875
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.57736807
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49797125
26Lysine degradation_Homo sapiens_hsa003101.48650683
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.45941336
28GABAergic synapse_Homo sapiens_hsa047271.42158099
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41160806
30RNA degradation_Homo sapiens_hsa030181.37578009
31Circadian entrainment_Homo sapiens_hsa047131.35272341
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33008129
33Cholinergic synapse_Homo sapiens_hsa047251.32804707
34Glutamatergic synapse_Homo sapiens_hsa047241.32390174
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.30613561
36mRNA surveillance pathway_Homo sapiens_hsa030151.29905804
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29280034
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24984329
39Notch signaling pathway_Homo sapiens_hsa043301.23541589
40TGF-beta signaling pathway_Homo sapiens_hsa043501.20932340
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.20852634
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.20337816
43Proteasome_Homo sapiens_hsa030501.19409484
44Systemic lupus erythematosus_Homo sapiens_hsa053221.19204954
45Dopaminergic synapse_Homo sapiens_hsa047281.18333565
46Cocaine addiction_Homo sapiens_hsa050301.18158230
47MicroRNAs in cancer_Homo sapiens_hsa052061.15726299
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12038110
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11766951
50Phospholipase D signaling pathway_Homo sapiens_hsa040721.11275838
51Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10943511
52Non-homologous end-joining_Homo sapiens_hsa034501.07312926
53Choline metabolism in cancer_Homo sapiens_hsa052311.05397713
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.05214422
55cAMP signaling pathway_Homo sapiens_hsa040241.04681701
56Folate biosynthesis_Homo sapiens_hsa007901.04393264
57T cell receptor signaling pathway_Homo sapiens_hsa046601.04307839
58PPAR signaling pathway_Homo sapiens_hsa033201.03067535
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02203367
60Prolactin signaling pathway_Homo sapiens_hsa049171.00774106
61Wnt signaling pathway_Homo sapiens_hsa043101.00448484
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99664342
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.99543246
64Biosynthesis of amino acids_Homo sapiens_hsa012300.98576735
65Glycerolipid metabolism_Homo sapiens_hsa005610.98027276
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.97181802
67HTLV-I infection_Homo sapiens_hsa051660.96699633
68Chemokine signaling pathway_Homo sapiens_hsa040620.95944091
69Osteoclast differentiation_Homo sapiens_hsa043800.94479013
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.94254053
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94040814
72Ras signaling pathway_Homo sapiens_hsa040140.92303863
73Phenylalanine metabolism_Homo sapiens_hsa003600.92115147
74Rap1 signaling pathway_Homo sapiens_hsa040150.92073781
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90139278
76Synaptic vesicle cycle_Homo sapiens_hsa047210.90133656
77TNF signaling pathway_Homo sapiens_hsa046680.88412644
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88205890
79MAPK signaling pathway_Homo sapiens_hsa040100.87958992
80Nitrogen metabolism_Homo sapiens_hsa009100.87792253
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87399041
82Primary immunodeficiency_Homo sapiens_hsa053400.87088613
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.85637877
84Fatty acid metabolism_Homo sapiens_hsa012120.85505337
85ErbB signaling pathway_Homo sapiens_hsa040120.84330869
86Oxytocin signaling pathway_Homo sapiens_hsa049210.83209216
87Adherens junction_Homo sapiens_hsa045200.82976071
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82752683
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82102168
90p53 signaling pathway_Homo sapiens_hsa041150.80409566
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79974324
92Malaria_Homo sapiens_hsa051440.79648870
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.79003072
94AMPK signaling pathway_Homo sapiens_hsa041520.78961822
95Herpes simplex infection_Homo sapiens_hsa051680.78818679
96Small cell lung cancer_Homo sapiens_hsa052220.77751903
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77555232
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76458559
99Gastric acid secretion_Homo sapiens_hsa049710.75594660
100Ovarian steroidogenesis_Homo sapiens_hsa049130.75436606
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75146024
102Type II diabetes mellitus_Homo sapiens_hsa049300.74766845
103Retinol metabolism_Homo sapiens_hsa008300.74475082
104Pathways in cancer_Homo sapiens_hsa052000.74105384
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73922256
106Thyroid cancer_Homo sapiens_hsa052160.72972402
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72778300
108VEGF signaling pathway_Homo sapiens_hsa043700.71919205
109Amphetamine addiction_Homo sapiens_hsa050310.71918221
110Long-term depression_Homo sapiens_hsa047300.71076255
111Taste transduction_Homo sapiens_hsa047420.70997658
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70820260
113Epstein-Barr virus infection_Homo sapiens_hsa051690.70596519
114Tryptophan metabolism_Homo sapiens_hsa003800.69211102
115Proteoglycans in cancer_Homo sapiens_hsa052050.69051279
116Steroid biosynthesis_Homo sapiens_hsa001000.68802319
117Endometrial cancer_Homo sapiens_hsa052130.68734418
118Salmonella infection_Homo sapiens_hsa051320.68033654
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.67959488
120GnRH signaling pathway_Homo sapiens_hsa049120.67894459
121Inositol phosphate metabolism_Homo sapiens_hsa005620.67488062
122Gap junction_Homo sapiens_hsa045400.67120554
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.65549772
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.65418416
125Purine metabolism_Homo sapiens_hsa002300.64493479
126Viral carcinogenesis_Homo sapiens_hsa052030.64375348
127Renin secretion_Homo sapiens_hsa049240.63477130
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63329552
129Serotonergic synapse_Homo sapiens_hsa047260.62934715
130Phototransduction_Homo sapiens_hsa047440.62318513
131Arginine biosynthesis_Homo sapiens_hsa002200.60669628
132Acute myeloid leukemia_Homo sapiens_hsa052210.60570878
133Tyrosine metabolism_Homo sapiens_hsa003500.60242001
134Fatty acid degradation_Homo sapiens_hsa000710.60220464
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60164544
136Dilated cardiomyopathy_Homo sapiens_hsa054140.59755110
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59045597
138Oocyte meiosis_Homo sapiens_hsa041140.58761404
139Estrogen signaling pathway_Homo sapiens_hsa049150.58550812
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57429278
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57093120
142Bladder cancer_Homo sapiens_hsa052190.56683403
143Fatty acid biosynthesis_Homo sapiens_hsa000610.56410909
144Basal transcription factors_Homo sapiens_hsa030220.56334598
145Fatty acid elongation_Homo sapiens_hsa000620.55218334
146Olfactory transduction_Homo sapiens_hsa047400.54923656
147Pertussis_Homo sapiens_hsa051330.54729676
148Viral myocarditis_Homo sapiens_hsa054160.54014753
149Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53979732
150Hepatitis C_Homo sapiens_hsa051600.53472537
151Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53039481
152Insulin signaling pathway_Homo sapiens_hsa049100.52211975
153Insulin secretion_Homo sapiens_hsa049110.51972888
154ECM-receptor interaction_Homo sapiens_hsa045120.51818992
155Arginine and proline metabolism_Homo sapiens_hsa003300.51809720
156NF-kappa B signaling pathway_Homo sapiens_hsa040640.51443192
157Sulfur relay system_Homo sapiens_hsa041220.51416909
158Protein digestion and absorption_Homo sapiens_hsa049740.51393599
159ABC transporters_Homo sapiens_hsa020100.51208180
160Insulin resistance_Homo sapiens_hsa049310.50520073
161Circadian rhythm_Homo sapiens_hsa047100.49888089
162Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49723616
163Colorectal cancer_Homo sapiens_hsa052100.49397177
164mTOR signaling pathway_Homo sapiens_hsa041500.48205024
165Complement and coagulation cascades_Homo sapiens_hsa046100.47938748
166Carbon metabolism_Homo sapiens_hsa012000.47332313
167Chronic myeloid leukemia_Homo sapiens_hsa052200.45585037
168Melanogenesis_Homo sapiens_hsa049160.44993989
169Tight junction_Homo sapiens_hsa045300.44867941
170Prostate cancer_Homo sapiens_hsa052150.44165945
171Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43293803
172Antigen processing and presentation_Homo sapiens_hsa046120.38828254
173Propanoate metabolism_Homo sapiens_hsa006400.37762314
174Focal adhesion_Homo sapiens_hsa045100.37138424
175PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32300972
176Galactose metabolism_Homo sapiens_hsa000520.31605993
177Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29956169
178Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29900822
179Pentose phosphate pathway_Homo sapiens_hsa000300.29871527
180Fat digestion and absorption_Homo sapiens_hsa049750.27270165
181Cyanoamino acid metabolism_Homo sapiens_hsa004600.26900118
182Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25508975
183HIF-1 signaling pathway_Homo sapiens_hsa040660.25097296
184Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24968960
185Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.24084040
186beta-Alanine metabolism_Homo sapiens_hsa004100.23664935

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