WDR87

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)6.45422075
2DNA methylation involved in gamete generation (GO:0043046)5.59393863
3sperm motility (GO:0030317)5.53904031
4acrosome reaction (GO:0007340)5.50489818
5regulation of meiosis I (GO:0060631)5.49816467
6axon ensheathment in central nervous system (GO:0032291)4.69595697
7central nervous system myelination (GO:0022010)4.69595697
8auditory receptor cell differentiation (GO:0042491)4.45868984
9axonemal dynein complex assembly (GO:0070286)4.35721647
10spermatid development (GO:0007286)4.20974559
11pattern specification involved in kidney development (GO:0061004)4.20068558
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.13085170
13L-phenylalanine catabolic process (GO:0006559)4.13085170
14tyrosine metabolic process (GO:0006570)4.12108631
15peristalsis (GO:0030432)4.10265394
16positive regulation of meiosis (GO:0045836)4.05346172
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.97377318
18cilium or flagellum-dependent cell motility (GO:0001539)3.86700403
19centriole replication (GO:0007099)3.80765342
20microtubule severing (GO:0051013)3.78672465
21positive regulation of meiotic cell cycle (GO:0051446)3.78386756
22sphingoid metabolic process (GO:0046519)3.71859039
23G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.71331901
24nephron epithelium morphogenesis (GO:0072088)3.64899762
25nephron tubule morphogenesis (GO:0072078)3.64899762
26positive regulation of developmental pigmentation (GO:0048087)3.64002493
27response to misfolded protein (GO:0051788)3.60431083
28protein polyglutamylation (GO:0018095)3.55338737
29multicellular organism reproduction (GO:0032504)3.54982582
30neuron fate determination (GO:0048664)3.53813085
31male meiosis (GO:0007140)3.51485923
32postsynaptic membrane organization (GO:0001941)3.50990460
33male meiosis I (GO:0007141)3.50848698
34negative regulation of astrocyte differentiation (GO:0048712)3.49442411
35sperm-egg recognition (GO:0035036)3.49128028
36fusion of sperm to egg plasma membrane (GO:0007342)3.48796713
37regulation of sarcomere organization (GO:0060297)3.45776181
38cellular ketone body metabolic process (GO:0046950)3.42322269
39negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.41847480
40aromatic amino acid family catabolic process (GO:0009074)3.35713313
41neuronal stem cell maintenance (GO:0097150)3.31558799
42cilium movement (GO:0003341)3.29816638
43telencephalon development (GO:0021537)3.27022273
44reflex (GO:0060004)3.26444726
45calcium ion-dependent exocytosis (GO:0017156)3.26375456
46erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.25317310
47L-phenylalanine metabolic process (GO:0006558)3.25317310
48sphingosine metabolic process (GO:0006670)3.22901938
49phosphatidylethanolamine metabolic process (GO:0046337)3.22426234
50protein K48-linked deubiquitination (GO:0071108)3.22006375
51indolalkylamine metabolic process (GO:0006586)3.18958112
52retina layer formation (GO:0010842)3.16532676
53regulation of female gonad development (GO:2000194)3.14204048
54mechanoreceptor differentiation (GO:0042490)3.13866852
55epithelial cilium movement (GO:0003351)3.11428387
56diol metabolic process (GO:0034311)3.09223286
57microtubule depolymerization (GO:0007019)3.05028089
58phosphatidylethanolamine biosynthetic process (GO:0006646)3.03468066
59ketone body metabolic process (GO:1902224)3.01181772
60binding of sperm to zona pellucida (GO:0007339)3.01147292
61dendritic spine morphogenesis (GO:0060997)2.99791704
62inner ear receptor cell differentiation (GO:0060113)2.98305214
63negative regulation of oligodendrocyte differentiation (GO:0048715)2.96944586
64radial glial cell differentiation (GO:0060019)2.96564002
65gonadal mesoderm development (GO:0007506)2.95509497
66regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.93299768
67male gamete generation (GO:0048232)2.92117965
68spermatogenesis (GO:0007283)2.91728167
69negative regulation of cAMP-mediated signaling (GO:0043951)2.90834517
70somite rostral/caudal axis specification (GO:0032525)2.89872962
71coenzyme catabolic process (GO:0009109)2.89387260
72protein K63-linked deubiquitination (GO:0070536)2.89345500
73detection of light stimulus involved in visual perception (GO:0050908)2.87130746
74detection of light stimulus involved in sensory perception (GO:0050962)2.87130746
75gene silencing by RNA (GO:0031047)2.86337472
76cell-cell recognition (GO:0009988)2.86309962
77reciprocal meiotic recombination (GO:0007131)2.85528339
78reciprocal DNA recombination (GO:0035825)2.85528339
79phasic smooth muscle contraction (GO:0014821)2.84993748
80microtubule polymerization or depolymerization (GO:0031109)2.84966049
81chromosome organization involved in meiosis (GO:0070192)2.84526643
82musculoskeletal movement (GO:0050881)2.82644214
83multicellular organismal movement (GO:0050879)2.82644214
84regulation of microtubule-based movement (GO:0060632)2.81465314
85centriole assembly (GO:0098534)2.76832018
86single strand break repair (GO:0000012)2.75612168
87primary amino compound metabolic process (GO:1901160)2.75492725
88neural tube formation (GO:0001841)2.73581022
89aromatic amino acid family metabolic process (GO:0009072)2.71938570
90germ cell development (GO:0007281)2.71513883
91cellular response to sterol (GO:0036315)2.71003241
92reproduction (GO:0000003)2.70830883
93gamete generation (GO:0007276)2.69540099
94regulation of pigment cell differentiation (GO:0050932)2.68481097
95synaptonemal complex assembly (GO:0007130)2.68314141
96tryptophan catabolic process (GO:0006569)2.66938330
97indole-containing compound catabolic process (GO:0042436)2.66938330
98indolalkylamine catabolic process (GO:0046218)2.66938330
99membrane depolarization during action potential (GO:0086010)2.66867663
100regulation of cilium movement (GO:0003352)2.66470830

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.29923018
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.11269344
3CTBP2_25329375_ChIP-Seq_LNCAP_Human2.80807362
4ZNF274_21170338_ChIP-Seq_K562_Hela2.63817595
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.39930124
6TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39930124
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34659106
8VDR_22108803_ChIP-Seq_LS180_Human2.31326099
9GBX2_23144817_ChIP-Seq_PC3_Human2.26013569
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.24371586
11DROSHA_22980978_ChIP-Seq_HELA_Human2.24354478
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92542215
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.90672080
14* AR_21572438_ChIP-Seq_LNCaP_Human1.82216206
15ER_23166858_ChIP-Seq_MCF-7_Human1.79561593
16IGF1R_20145208_ChIP-Seq_DFB_Human1.76341802
17CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.74938275
18CBX2_27304074_Chip-Seq_ESCs_Mouse1.73348372
19REST_21632747_ChIP-Seq_MESCs_Mouse1.71547305
20STAT3_23295773_ChIP-Seq_U87_Human1.70113662
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69536017
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66189157
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.63542295
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62959842
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.62905166
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61472981
27P300_19829295_ChIP-Seq_ESCs_Human1.61143640
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57410227
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.54249712
30SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51253982
31TCF4_23295773_ChIP-Seq_U87_Human1.48553530
32SMAD4_21799915_ChIP-Seq_A2780_Human1.48524899
33AR_25329375_ChIP-Seq_VCAP_Human1.46820773
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.46466028
35TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44125338
36SMAD4_21741376_ChIP-Seq_EPCs_Human1.42496537
37FUS_26573619_Chip-Seq_HEK293_Human1.42186967
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.42077908
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.39620302
40CBP_20019798_ChIP-Seq_JUKART_Human1.39538855
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39538855
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37599416
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36844542
44* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35902546
45SMAD3_21741376_ChIP-Seq_ESCs_Human1.35233295
46JARID2_20064375_ChIP-Seq_MESCs_Mouse1.33130179
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31871056
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.31357588
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27918469
50BCAT_22108803_ChIP-Seq_LS180_Human1.25057928
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24726968
52RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24726968
53CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24637785
54SOX2_19829295_ChIP-Seq_ESCs_Human1.23990560
55NANOG_19829295_ChIP-Seq_ESCs_Human1.23990560
56RNF2_27304074_Chip-Seq_NSC_Mouse1.23627293
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22913719
58RUNX2_22187159_ChIP-Seq_PCA_Human1.21999387
59MYC_19829295_ChIP-Seq_ESCs_Human1.21168506
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20531398
61OCT4_20526341_ChIP-Seq_ESCs_Human1.20158013
62ERA_21632823_ChIP-Seq_H3396_Human1.18336969
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.17642431
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.15972905
65SMAD4_21741376_ChIP-Seq_HESCs_Human1.15396239
66CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14732075
67RXR_22108803_ChIP-Seq_LS180_Human1.14110882
68SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13795916
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12713152
70OCT1_27270436_Chip-Seq_PROSTATE_Human1.11796803
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11498395
72EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11245096
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.11234526
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.11088663
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10508789
76KDM2B_26808549_Chip-Seq_REH_Human1.08428864
77TCF4_22108803_ChIP-Seq_LS180_Human1.07843784
78AR_19668381_ChIP-Seq_PC3_Human1.05998210
79TP53_18474530_ChIP-ChIP_U2OS_Human1.05767201
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04293835
81REST_18959480_ChIP-ChIP_MESCs_Mouse1.03919142
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03671307
83CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03613910
84* HOXB7_26014856_ChIP-Seq_BT474_Human1.03231424
85MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03145417
86SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02318564
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01552733
88NANOG_20526341_ChIP-Seq_ESCs_Human1.01542152
89WDR5_24793694_ChIP-Seq_LNCAP_Human1.00836800
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00109622
91TP63_19390658_ChIP-ChIP_HaCaT_Human0.96962452
92EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96584641
93RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96293748
94TAF2_19829295_ChIP-Seq_ESCs_Human0.95740480
95TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95570232
96CTCF_27219007_Chip-Seq_Bcells_Human0.94555066
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93037432
98TBL1_22424771_ChIP-Seq_293T_Human0.91876268
99PHF8_20622853_ChIP-Seq_HELA_Human0.91515355
100ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90604838

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.00245928
2MP0003136_yellow_coat_color4.75847345
3MP0005410_abnormal_fertilization3.61179651
4MP0003646_muscle_fatigue3.23341694
5MP0003878_abnormal_ear_physiology2.98515262
6MP0005377_hearing/vestibular/ear_phenot2.98515262
7MP0001501_abnormal_sleep_pattern2.88123517
8MP0005171_absent_coat_pigmentation2.87348354
9MP0005670_abnormal_white_adipose2.85496980
10MP0004147_increased_porphyrin_level2.79255633
11MP0003879_abnormal_hair_cell2.44727869
12MP0002653_abnormal_ependyma_morphology2.31634243
13MP0002735_abnormal_chemical_nociception2.29309739
14MP0003880_abnormal_central_pattern2.07817237
15MP0003698_abnormal_male_reproductive2.03225158
16MP0008877_abnormal_DNA_methylation2.01299773
17MP0003045_fibrosis1.99276552
18MP0001348_abnormal_lacrimal_gland1.91693433
19MP0009046_muscle_twitch1.90010430
20MP0009745_abnormal_behavioral_response1.89671901
21MP0000569_abnormal_digit_pigmentation1.88536590
22MP0002822_catalepsy1.86283230
23MP0001486_abnormal_startle_reflex1.80405976
24MP0002733_abnormal_thermal_nociception1.75715470
25MP0003195_calcinosis1.73326712
26MP0001929_abnormal_gametogenesis1.63490330
27MP0002638_abnormal_pupillary_reflex1.63065612
28MP0005551_abnormal_eye_electrophysiolog1.62104003
29MP0002572_abnormal_emotion/affect_behav1.61318765
30MP0003890_abnormal_embryonic-extraembry1.53913590
31MP0001970_abnormal_pain_threshold1.51140673
32MP0004858_abnormal_nervous_system1.51103996
33MP0006276_abnormal_autonomic_nervous1.48351842
34MP0003718_maternal_effect1.45777620
35MP0001905_abnormal_dopamine_level1.45397182
36MP0000026_abnormal_inner_ear1.45303351
37MP0004381_abnormal_hair_follicle1.43635547
38MP0005645_abnormal_hypothalamus_physiol1.43473050
39MP0002138_abnormal_hepatobiliary_system1.39713816
40MP0002210_abnormal_sex_determination1.38803396
41MP0005167_abnormal_blood-brain_barrier1.38617401
42MP0002557_abnormal_social/conspecific_i1.38445759
43MP0001485_abnormal_pinna_reflex1.37411451
44MP0003635_abnormal_synaptic_transmissio1.36850025
45MP0000015_abnormal_ear_pigmentation1.33257001
46MP0001968_abnormal_touch/_nociception1.33101988
47MP0002272_abnormal_nervous_system1.31450059
48MP0000678_abnormal_parathyroid_gland1.29137684
49MP0001963_abnormal_hearing_physiology1.24391790
50MP0002067_abnormal_sensory_capabilities1.19241475
51MP0005423_abnormal_somatic_nervous1.18437177
52MP0004142_abnormal_muscle_tone1.17042715
53MP0009697_abnormal_copulation1.15579166
54MP0004859_abnormal_synaptic_plasticity1.13284434
55MP0002064_seizures1.12618550
56MP0000955_abnormal_spinal_cord1.07218246
57MP0004043_abnormal_pH_regulation1.06805010
58MP0003119_abnormal_digestive_system1.06556718
59MP0001440_abnormal_grooming_behavior1.05820206
60MP0000653_abnormal_sex_gland1.05253042
61MP0003137_abnormal_impulse_conducting1.04926505
62MP0002938_white_spotting1.04605241
63MP0005646_abnormal_pituitary_gland1.04231955
64MP0000230_abnormal_systemic_arterial1.02259019
65MP0005174_abnormal_tail_pigmentation1.01807403
66MP0008872_abnormal_physiological_respon1.01607955
67MP0002229_neurodegeneration1.01131097
68MP0002095_abnormal_skin_pigmentation0.99916580
69MP0002161_abnormal_fertility/fecundity0.99001537
70MP0002876_abnormal_thyroid_physiology0.98952859
71MP0002063_abnormal_learning/memory/cond0.97439237
72MP0005395_other_phenotype0.95856038
73MP0001145_abnormal_male_reproductive0.95640653
74MP0001188_hyperpigmentation0.95581211
75MP0002184_abnormal_innervation0.93990773
76MP0002734_abnormal_mechanical_nocicepti0.93506796
77MP0008569_lethality_at_weaning0.92997413
78MP0005195_abnormal_posterior_eye0.92983196
79MP0001986_abnormal_taste_sensitivity0.87854222
80MP0000778_abnormal_nervous_system0.87377950
81MP0004085_abnormal_heartbeat0.85787784
82MP0004924_abnormal_behavior0.85347450
83MP0005386_behavior/neurological_phenoty0.85347450
84MP0001664_abnormal_digestion0.84956820
85MP0002752_abnormal_somatic_nervous0.84051101
86MP0002168_other_aberrant_phenotype0.83970654
87MP0000049_abnormal_middle_ear0.81687234
88MP0005253_abnormal_eye_physiology0.79561776
89MP0002882_abnormal_neuron_morphology0.79187253
90MP0002249_abnormal_larynx_morphology0.76158746
91MP0003861_abnormal_nervous_system0.75878053
92MP0004742_abnormal_vestibular_system0.74824681
93MP0000470_abnormal_stomach_morphology0.74722111
94MP0005075_abnormal_melanosome_morpholog0.73177690
95MP0005085_abnormal_gallbladder_physiolo0.71424859
96MP0000371_diluted_coat_color0.68609302
97MP0000372_irregular_coat_pigmentation0.67961080
98MP0003638_abnormal_response/metabolism_0.66710032
99MP0000631_abnormal_neuroendocrine_gland0.66413100
100MP0006292_abnormal_olfactory_placode0.63643685

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)5.57977190
2Severe visual impairment (HP:0001141)4.37988142
3Progressive cerebellar ataxia (HP:0002073)4.25308409
4Abnormal ciliary motility (HP:0012262)4.20791122
5Pancreatic cysts (HP:0001737)4.09880767
6Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.03814689
7Congenital stationary night blindness (HP:0007642)3.94504907
8Abnormal respiratory epithelium morphology (HP:0012253)3.56015362
9Abnormal respiratory motile cilium morphology (HP:0005938)3.56015362
10Pancreatic fibrosis (HP:0100732)3.50113721
11Nephronophthisis (HP:0000090)3.48321623
12Abnormal respiratory motile cilium physiology (HP:0012261)3.45643116
13Cystic liver disease (HP:0006706)3.41022208
14Birth length less than 3rd percentile (HP:0003561)3.38853671
15Absent/shortened dynein arms (HP:0200106)3.34226079
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.34226079
17Retinal dysplasia (HP:0007973)3.33050165
18Abnormality of the renal medulla (HP:0100957)3.26123196
19Focal motor seizures (HP:0011153)3.21295843
20Attenuation of retinal blood vessels (HP:0007843)3.16965616
21Gaze-evoked nystagmus (HP:0000640)3.07545309
22True hermaphroditism (HP:0010459)3.00724322
23Amelogenesis imperfecta (HP:0000705)2.95813470
24Abnormal rod and cone electroretinograms (HP:0008323)2.83765096
25Sclerocornea (HP:0000647)2.76331155
26Myokymia (HP:0002411)2.72145530
27Optic nerve hypoplasia (HP:0000609)2.67310966
28Abnormality of macular pigmentation (HP:0008002)2.66218870
29Type II lissencephaly (HP:0007260)2.66134588
30Hypoplastic ischia (HP:0003175)2.61979220
31Bell-shaped thorax (HP:0001591)2.61084000
32Proximal tubulopathy (HP:0000114)2.60142105
33Urinary bladder sphincter dysfunction (HP:0002839)2.59318010
34Decreased central vision (HP:0007663)2.58487615
35Abnormality of the renal cortex (HP:0011035)2.57957893
36Postural instability (HP:0002172)2.56297088
37Pendular nystagmus (HP:0012043)2.51686281
38Bony spicule pigmentary retinopathy (HP:0007737)2.47153557
39Patellar aplasia (HP:0006443)2.47026429
40Hyperventilation (HP:0002883)2.46735057
41Abnormality of the pubic bones (HP:0003172)2.45189976
42Abnormality of binocular vision (HP:0011514)2.44377225
43Diplopia (HP:0000651)2.44377225
44Dysmetric saccades (HP:0000641)2.41474510
45Abnormality of the ischium (HP:0003174)2.41357048
46Tubular atrophy (HP:0000092)2.37523503
47Abnormality of the renal collecting system (HP:0004742)2.36181187
48Albinism (HP:0001022)2.35457190
49Duplicated collecting system (HP:0000081)2.35052714
50Congenital sensorineural hearing impairment (HP:0008527)2.33368868
51Aplasia/Hypoplasia of the patella (HP:0006498)2.31724681
52Oligodactyly (hands) (HP:0001180)2.31037012
53Aplasia/Hypoplasia of the fovea (HP:0008060)2.30533751
54Hypoplasia of the fovea (HP:0007750)2.30533751
55Chorioretinal atrophy (HP:0000533)2.28667188
56Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.25304650
57Potter facies (HP:0002009)2.23004976
58Facial shape deformation (HP:0011334)2.23004976
59Abnormality of the diencephalon (HP:0010662)2.22088859
60Protruding tongue (HP:0010808)2.21634719
61Thyroid-stimulating hormone excess (HP:0002925)2.21309913
62Polydipsia (HP:0001959)2.21229123
63Abnormal drinking behavior (HP:0030082)2.21229123
64Keratoconus (HP:0000563)2.18561352
65Increased corneal curvature (HP:0100692)2.18561352
66Depressed nasal tip (HP:0000437)2.16309212
67Chromosomal breakage induced by crosslinking agents (HP:0003221)2.13072626
68Inability to walk (HP:0002540)2.11117497
69Scotoma (HP:0000575)2.10713026
70Hyperkalemia (HP:0002153)2.09821831
71Abnormality of DNA repair (HP:0003254)2.08313577
72Decreased circulating renin level (HP:0003351)2.05287258
73Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.04950557
74Abnormality of the anterior chamber (HP:0000593)2.03420878
75Aplasia/Hypoplasia of the uvula (HP:0010293)2.03255727
76Hypoplasia of the iris (HP:0007676)2.02994406
77Breast hypoplasia (HP:0003187)2.00069642
78Congenital hepatic fibrosis (HP:0002612)1.99396030
79Cerebellar dysplasia (HP:0007033)1.98105973
80Abnormality of midbrain morphology (HP:0002418)1.97186107
81Molar tooth sign on MRI (HP:0002419)1.97186107
82Rhinitis (HP:0012384)1.96578927
83Dialeptic seizures (HP:0011146)1.95865922
84Enlarged kidneys (HP:0000105)1.95670811
85Abnormality of the vitreous humor (HP:0004327)1.87415506
86Absent forearm bone (HP:0003953)1.86868089
87Aplasia involving forearm bones (HP:0009822)1.86868089
88Parakeratosis (HP:0001036)1.86633359
89Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.86361368
90Chronic hepatic failure (HP:0100626)1.86360057
91Lissencephaly (HP:0001339)1.84688798
92Anencephaly (HP:0002323)1.83897111
93Focal seizures (HP:0007359)1.83276671
94Difficulty walking (HP:0002355)1.82011722
95Tubulointerstitial abnormality (HP:0001969)1.79501059
96Hypoplastic iliac wings (HP:0002866)1.78500939
97Aplasia/Hypoplasia of the sternum (HP:0006714)1.78022242
98Large for gestational age (HP:0001520)1.77885850
99Macular degeneration (HP:0000608)1.75357462
100Acanthocytosis (HP:0001927)1.72537347

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.57566105
2LATS15.38026964
3ACVR1B4.67895535
4STK38L4.47043247
5BMPR1B3.92837060
6STK382.82522302
7ADRBK22.53046309
8PINK12.28256390
9INSRR2.24090539
10NTRK22.15036655
11STK32.13793998
12WNK42.09256392
13LATS22.03887607
14ZAK2.01218671
15PRKD31.99515553
16DDR21.97366755
17SIK21.75860854
18GRK11.73695903
19DAPK21.71349333
20PNCK1.67700783
21EPHA31.66550575
22TGFBR11.65496797
23CASK1.62950360
24NEK21.58628974
25PTK2B1.49585266
26PLK41.44164045
27NTRK31.30222498
28ADRBK11.26734105
29MAP4K21.26716749
30STK111.22129825
31STK391.21922185
32TYRO31.21653376
33MELK1.17721383
34TNK21.08611150
35PRKG20.99735382
36MST40.98328165
37MARK30.90801472
38PIK3CG0.89478624
39PRKCE0.87757746
40PRKCG0.86156009
41CAMK1G0.76863840
42PLK20.73489222
43PRKAA20.71304494
44MST1R0.66584530
45WNK10.65422531
46MAP3K70.64776486
47TNIK0.62869794
48OXSR10.62298806
49FES0.61418323
50MAPK110.60688179
51TAOK30.59363388
52NME10.57069573
53MAPK130.55676753
54MAP2K10.54205287
55PDPK10.53939597
56CAMK2A0.53000405
57MKNK20.51821141
58BCR0.51408780
59MAPK150.48680006
60DYRK20.48337645
61MAP2K20.44992206
62MARK10.44857099
63CAMKK10.44595139
64MAP3K40.43116240
65WNK30.40205878
66PRKG10.37763602
67NUAK10.36793747
68TESK10.36781126
69PKN10.36455422
70PRKCZ0.35611141
71CSNK1A10.34711193
72KIT0.34605941
73CAMK10.33377684
74PRKCH0.32954484
75GSK3B0.32295354
76RPS6KA60.29557540
77NEK90.29449798
78PLK10.27820475
79CDK80.25878026
80PRKACA0.25128322
81MAPK80.23562464
82MAP3K20.21627382
83CDK30.21573238
84FGFR30.21549932
85SGK10.21196549
86CDK10.20147432
87PRKCB0.20146652
88PRKACB0.19703013
89PDK10.18439607
90CDK50.18373995
91PDGFRB0.18027957
92MET0.17909569
93AKT10.17641907
94CAMK40.17214679
95NLK0.16504009
96EPHB20.15779876
97RPS6KA30.15676498
98PRKCQ0.15236645
99MAPK10.14657409
100AKT30.14431284

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.94107882
2Phototransduction_Homo sapiens_hsa047442.92925237
3Taste transduction_Homo sapiens_hsa047422.69980409
4Morphine addiction_Homo sapiens_hsa050322.53612944
5Butanoate metabolism_Homo sapiens_hsa006502.49928764
6Dorso-ventral axis formation_Homo sapiens_hsa043202.39180353
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.30549839
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29922632
9Olfactory transduction_Homo sapiens_hsa047402.25129642
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.24433219
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.18209813
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.12141246
13ABC transporters_Homo sapiens_hsa020102.10697168
14GABAergic synapse_Homo sapiens_hsa047272.06283296
15Fatty acid biosynthesis_Homo sapiens_hsa000612.03121714
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.01197506
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.82415704
18Calcium signaling pathway_Homo sapiens_hsa040201.74740569
19Circadian entrainment_Homo sapiens_hsa047131.71755390
20Glutamatergic synapse_Homo sapiens_hsa047241.66828955
21Insulin secretion_Homo sapiens_hsa049111.64432699
22Tryptophan metabolism_Homo sapiens_hsa003801.63802232
23Serotonergic synapse_Homo sapiens_hsa047261.59494873
24Homologous recombination_Homo sapiens_hsa034401.54450677
25Sulfur relay system_Homo sapiens_hsa041221.41487217
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34896572
27Nitrogen metabolism_Homo sapiens_hsa009101.31364796
28Sphingolipid metabolism_Homo sapiens_hsa006001.30417405
29Linoleic acid metabolism_Homo sapiens_hsa005911.30262853
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.29559449
31Salivary secretion_Homo sapiens_hsa049701.28750432
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27483541
33Tyrosine metabolism_Homo sapiens_hsa003501.26301376
34Glycerolipid metabolism_Homo sapiens_hsa005611.25374530
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.23162275
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.22101641
37Bile secretion_Homo sapiens_hsa049761.13245418
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12155034
39Gastric acid secretion_Homo sapiens_hsa049711.11331814
40beta-Alanine metabolism_Homo sapiens_hsa004101.08952735
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.03772355
42Hedgehog signaling pathway_Homo sapiens_hsa043401.00744584
43Selenocompound metabolism_Homo sapiens_hsa004501.00389018
44Glycerophospholipid metabolism_Homo sapiens_hsa005640.99885059
45cAMP signaling pathway_Homo sapiens_hsa040240.98751640
46Chemical carcinogenesis_Homo sapiens_hsa052040.96023749
47Cholinergic synapse_Homo sapiens_hsa047250.95156986
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94573284
49Retinol metabolism_Homo sapiens_hsa008300.94140751
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93480519
51Lysine degradation_Homo sapiens_hsa003100.92212926
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91417876
53Basal transcription factors_Homo sapiens_hsa030220.90566369
54Ovarian steroidogenesis_Homo sapiens_hsa049130.90077842
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89842026
56Histidine metabolism_Homo sapiens_hsa003400.89170528
57Arginine and proline metabolism_Homo sapiens_hsa003300.88825236
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86332297
59Long-term depression_Homo sapiens_hsa047300.84967116
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84803602
61Cocaine addiction_Homo sapiens_hsa050300.83783947
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82045479
63Propanoate metabolism_Homo sapiens_hsa006400.81930608
64Oxytocin signaling pathway_Homo sapiens_hsa049210.81709646
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78324622
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76068935
67Basal cell carcinoma_Homo sapiens_hsa052170.68240731
68Type II diabetes mellitus_Homo sapiens_hsa049300.67888554
69Cardiac muscle contraction_Homo sapiens_hsa042600.66298005
70Notch signaling pathway_Homo sapiens_hsa043300.65163607
71Gap junction_Homo sapiens_hsa045400.64637653
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62904801
73Renin-angiotensin system_Homo sapiens_hsa046140.61334001
74Fatty acid degradation_Homo sapiens_hsa000710.58369114
75Pancreatic secretion_Homo sapiens_hsa049720.57825511
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57597669
77Protein digestion and absorption_Homo sapiens_hsa049740.54259699
78Axon guidance_Homo sapiens_hsa043600.52432936
79Thyroid hormone synthesis_Homo sapiens_hsa049180.51292522
80Estrogen signaling pathway_Homo sapiens_hsa049150.50276996
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49604544
82Peroxisome_Homo sapiens_hsa041460.49063945
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48232134
84Mineral absorption_Homo sapiens_hsa049780.46699789
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44708873
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43939738
87Ether lipid metabolism_Homo sapiens_hsa005650.43671290
88Dilated cardiomyopathy_Homo sapiens_hsa054140.43057643
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42407088
90Fanconi anemia pathway_Homo sapiens_hsa034600.40258887
91Hippo signaling pathway_Homo sapiens_hsa043900.38395738
92ECM-receptor interaction_Homo sapiens_hsa045120.36181089
93Arachidonic acid metabolism_Homo sapiens_hsa005900.33841972
94PPAR signaling pathway_Homo sapiens_hsa033200.33711156
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.33407828
96Vitamin digestion and absorption_Homo sapiens_hsa049770.33001887
97Dopaminergic synapse_Homo sapiens_hsa047280.32128385
98RNA degradation_Homo sapiens_hsa030180.31822211
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31391621
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29888331

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