WDR88

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of mitochondrial fission (GO:0090141)5.80822218
2positive regulation of granulocyte differentiation (GO:0030854)5.37511947
3positive regulation of B cell differentiation (GO:0045579)5.22678833
4DNA topological change (GO:0006265)5.19621244
5peptidyl-arginine omega-N-methylation (GO:0035247)5.03395441
6snRNA processing (GO:0016180)4.85684386
7histone H2A acetylation (GO:0043968)4.56339530
8peptidyl-arginine N-methylation (GO:0035246)4.51741209
9peptidyl-arginine methylation (GO:0018216)4.51741209
10snRNA metabolic process (GO:0016073)4.49903490
11DNA integration (GO:0015074)4.46098195
12base-excision repair, AP site formation (GO:0006285)4.41354473
13pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.21575050
14regulation of mitochondrial fission (GO:0090140)4.07517824
15branched-chain amino acid catabolic process (GO:0009083)4.05510477
16histone arginine methylation (GO:0034969)4.02669150
17branched-chain amino acid metabolic process (GO:0009081)3.94728344
18positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.89083285
19pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.83231915
20intraciliary transport (GO:0042073)3.80020810
21peptidyl-histidine modification (GO:0018202)3.72337552
22seminiferous tubule development (GO:0072520)3.70064483
23galactose catabolic process (GO:0019388)3.64031597
24ventricular system development (GO:0021591)3.62003111
25mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.60210454
26deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.58451506
27regulation of granulocyte differentiation (GO:0030852)3.49412706
28cartilage morphogenesis (GO:0060536)3.49284895
29regulation of histone H3-K27 methylation (GO:0061085)3.39545711
30ncRNA 3-end processing (GO:0043628)3.37885741
31mitochondrial fission (GO:0000266)3.33614834
32poly(A)+ mRNA export from nucleus (GO:0016973)3.28157966
33ubiquinone biosynthetic process (GO:0006744)3.23903148
34mitochondrial fusion (GO:0008053)3.21518266
35pyrimidine nucleotide catabolic process (GO:0006244)3.21196972
36GPI anchor biosynthetic process (GO:0006506)3.20816146
37valine metabolic process (GO:0006573)3.18296297
38nuclear pore complex assembly (GO:0051292)3.15223221
39peroxisome fission (GO:0016559)3.12223635
40cellular response to exogenous dsRNA (GO:0071360)3.10016790
41positive regulation of bone resorption (GO:0045780)3.07020888
42positive regulation of bone remodeling (GO:0046852)3.07020888
43leukocyte tethering or rolling (GO:0050901)3.05169147
44nephron tubule morphogenesis (GO:0072078)3.05032257
45nephron epithelium morphogenesis (GO:0072088)3.05032257
46regulation of RNA export from nucleus (GO:0046831)3.00812086
47regulation of B cell differentiation (GO:0045577)2.99496704
48negative regulation of erythrocyte differentiation (GO:0045647)2.99374863
49regulation of nucleobase-containing compound transport (GO:0032239)2.98253975
50nucleoside diphosphate biosynthetic process (GO:0009133)2.98018352
51histone H3-K4 methylation (GO:0051568)2.97236303
52Peyers patch development (GO:0048541)2.97223825
53mucosal-associated lymphoid tissue development (GO:0048537)2.97223825
54microtubule nucleation (GO:0007020)2.95428599
55ubiquinone metabolic process (GO:0006743)2.94998812
56regulation of translational fidelity (GO:0006450)2.93682826
57mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.91881508
58positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.91881508
59pore complex assembly (GO:0046931)2.90662130
60mitochondrial RNA metabolic process (GO:0000959)2.88833883
61protein-DNA complex disassembly (GO:0032986)2.86896200
62nucleosome disassembly (GO:0006337)2.86896200
63Arp2/3 complex-mediated actin nucleation (GO:0034314)2.86259952
64cytoplasmic mRNA processing body assembly (GO:0033962)2.85798705
65regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.84126607
66negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.83358997
67intracellular estrogen receptor signaling pathway (GO:0030520)2.82494495
68negative regulation of cell size (GO:0045792)2.80849239
69establishment of mitochondrion localization (GO:0051654)2.79543649
702-deoxyribonucleotide metabolic process (GO:0009394)2.77813872
71positive regulation of receptor biosynthetic process (GO:0010870)2.77704490
72regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.77012792
73mRNA splice site selection (GO:0006376)2.76896583
74peptidyl-arginine modification (GO:0018195)2.76289569
75positive regulation of protein targeting to membrane (GO:0090314)2.75642437
76tRNA aminoacylation for protein translation (GO:0006418)2.75455672
77proline biosynthetic process (GO:0006561)2.74803429
78GPI anchor metabolic process (GO:0006505)2.74023978
79histone H3-K9 methylation (GO:0051567)2.73954923
80histone H4 deacetylation (GO:0070933)2.73387330
81preassembly of GPI anchor in ER membrane (GO:0016254)2.71336339
82stress granule assembly (GO:0034063)2.71056501
83histone methylation (GO:0016571)2.68939290
84histone lysine methylation (GO:0034968)2.67948456
85negative regulation of JAK-STAT cascade (GO:0046426)2.66538423
86B cell receptor signaling pathway (GO:0050853)2.66391189
87organ growth (GO:0035265)2.66330021
88regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:22.63043220
89motile cilium assembly (GO:0044458)2.62913479
90histone H4-K5 acetylation (GO:0043981)2.62314809
91histone H4-K8 acetylation (GO:0043982)2.62314809
92glycolytic process (GO:0006096)2.61164303
93negative regulation of gluconeogenesis (GO:0045721)2.60922974
94cellular response to dsRNA (GO:0071359)2.60658101
95metallo-sulfur cluster assembly (GO:0031163)2.59871410
96iron-sulfur cluster assembly (GO:0016226)2.59871410
97quinone biosynthetic process (GO:1901663)2.59812872
98tRNA aminoacylation (GO:0043039)2.59579373
99amino acid activation (GO:0043038)2.59579373
100glycolipid biosynthetic process (GO:0009247)2.59020567

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.86942116
2HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.74073005
3CIITA_25753668_ChIP-Seq_RAJI_Human3.69371894
4E2F7_22180533_ChIP-Seq_HELA_Human3.44121432
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.39621806
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.02873163
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.89656274
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.81758933
9DCP1A_22483619_ChIP-Seq_HELA_Human2.79411007
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66715583
11KDM5A_27292631_Chip-Seq_BREAST_Human2.55623639
12ESR1_15608294_ChIP-ChIP_MCF-7_Human2.54681689
13GABP_19822575_ChIP-Seq_HepG2_Human2.50440737
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.39913412
15IRF1_19129219_ChIP-ChIP_H3396_Human2.25422246
16MYC_22102868_ChIP-Seq_BL_Human2.25404281
17VDR_23849224_ChIP-Seq_CD4+_Human2.21613554
18ZNF274_21170338_ChIP-Seq_K562_Hela2.18701288
19YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.18375035
20PADI4_21655091_ChIP-ChIP_MCF-7_Human2.14553051
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.09688271
22VDR_21846776_ChIP-Seq_THP-1_Human2.07556472
23CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.05149218
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97316975
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94981345
26PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.94827828
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87009062
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.85043767
29ZNF263_19887448_ChIP-Seq_K562_Human1.82723502
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.81381098
31FOXP3_21729870_ChIP-Seq_TREG_Human1.80920857
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.72618145
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72441690
34PKCTHETA_26484144_Chip-Seq_BREAST_Human1.69202173
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68624301
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.66181012
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.62406479
38SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.62130678
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.62114769
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61841805
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60054297
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59903695
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59108661
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58992397
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54151839
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52791521
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50854476
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50756126
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50562581
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48606961
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48489934
52IRF8_22096565_ChIP-ChIP_GC-B_Human1.47419140
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.46875880
54SCL_19346495_ChIP-Seq_HPC-7_Human1.46511804
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45710060
56XRN2_22483619_ChIP-Seq_HELA_Human1.45058946
57GABP_17652178_ChIP-ChIP_JURKAT_Human1.44479823
58E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.44096561
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43264339
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42776884
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41533459
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40496112
63CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.39511620
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38287685
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37577928
66SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.34762135
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34365964
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32940078
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30248183
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29354655
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28430266
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25583986
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24073787
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23004740
75CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22660967
76MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.20451711
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19075921
78GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18443803
79TAF15_26573619_Chip-Seq_HEK293_Human1.13939650
80TTF2_22483619_ChIP-Seq_HELA_Human1.11541739
81MYB_26560356_Chip-Seq_TH2_Human1.11057479
82E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05965642
83ELK4_26923725_Chip-Seq_MESODERM_Mouse1.05213253
84MYB_26560356_Chip-Seq_TH1_Human1.05167014
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.04422303
86FOXP1_21924763_ChIP-Seq_HESCs_Human1.03655872
87TFEB_21752829_ChIP-Seq_HELA_Human1.02846579
88E2F1_21310950_ChIP-Seq_MCF-7_Human1.02693400
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02513573
90SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.01698268
91SPI1_23547873_ChIP-Seq_NB4_Human1.01640694
92E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01483208
93MYC_18940864_ChIP-ChIP_HL60_Human1.00878995
94ELK1_19687146_ChIP-ChIP_HELA_Human0.99488755
95* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99390487
96PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97664305
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97569562
98* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97280890
99PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95875598
100MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92142392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence3.91215326
2MP0002822_catalepsy3.34460535
3MP0008877_abnormal_DNA_methylation3.12426153
4MP0008961_abnormal_basal_metabolism2.99525545
5MP0001661_extended_life_span2.52465871
6MP0002009_preneoplasia2.49931879
7MP0003787_abnormal_imprinting2.48017203
8MP0000579_abnormal_nail_morphology2.45940945
9MP0005451_abnormal_body_composition2.45870291
10MP0005645_abnormal_hypothalamus_physiol2.38857104
11MP0002396_abnormal_hematopoietic_system2.23637104
12MP0006035_abnormal_mitochondrial_morpho2.01588146
13MP0001545_abnormal_hematopoietic_system2.00044266
14MP0005397_hematopoietic_system_phenotyp2.00044266
15MP0000013_abnormal_adipose_tissue1.97829345
16MP0004133_heterotaxia1.91778729
17MP0003111_abnormal_nucleus_morphology1.88193788
18MP0005646_abnormal_pituitary_gland1.86668212
19MP0004808_abnormal_hematopoietic_stem1.83252837
20MP0002249_abnormal_larynx_morphology1.82030544
21MP0002653_abnormal_ependyma_morphology1.79674021
22MP0006276_abnormal_autonomic_nervous1.78060778
23MP0001873_stomach_inflammation1.76267693
24MP0003121_genomic_imprinting1.67055032
25MP0008058_abnormal_DNA_repair1.62029293
26MP0001986_abnormal_taste_sensitivity1.61634865
27MP0003221_abnormal_cardiomyocyte_apopto1.57378581
28MP0004859_abnormal_synaptic_plasticity1.53770760
29MP0002282_abnormal_trachea_morphology1.50438218
30MP0000358_abnormal_cell_content/1.48207643
31MP0009278_abnormal_bone_marrow1.48167472
32MP0005410_abnormal_fertilization1.47979720
33MP0003693_abnormal_embryo_hatching1.46093235
34MP0005248_abnormal_Harderian_gland1.45563059
35MP0003077_abnormal_cell_cycle1.43461847
36MP0008932_abnormal_embryonic_tissue1.39204027
37MP0003786_premature_aging1.38160593
38MP0004145_abnormal_muscle_electrophysio1.35970618
39MP0003122_maternal_imprinting1.35446815
40MP0003656_abnormal_erythrocyte_physiolo1.30117136
41MP0004043_abnormal_pH_regulation1.21847581
42MP0001529_abnormal_vocalization1.20327079
43MP0001764_abnormal_homeostasis1.17465034
44MP0001727_abnormal_embryo_implantation1.16159926
45MP0000613_abnormal_salivary_gland1.14263418
46MP0010094_abnormal_chromosome_stability1.11875234
47MP0000350_abnormal_cell_proliferation1.05793744
48MP0002132_abnormal_respiratory_system1.05250291
49MP0008007_abnormal_cellular_replicative1.05165023
50MP0004130_abnormal_muscle_cell1.03788750
51MP0005266_abnormal_metabolism1.03539341
52MP0003890_abnormal_embryonic-extraembry1.03414071
53MP0002751_abnormal_autonomic_nervous1.02978742
54MP0003698_abnormal_male_reproductive1.02069203
55MP0005171_absent_coat_pigmentation1.00529112
56MP0000689_abnormal_spleen_morphology0.99446989
57MP0005384_cellular_phenotype0.98628695
58MP0005535_abnormal_body_temperature0.95040906
59MP0000733_abnormal_muscle_development0.92602185
60MP0005220_abnormal_exocrine_pancreas0.91034287
61MP0003172_abnormal_lysosome_physiology0.90771422
62MP0002970_abnormal_white_adipose0.90551570
63MP0004147_increased_porphyrin_level0.89513707
64MP0002722_abnormal_immune_system0.87925960
65MP0003959_abnormal_lean_body0.87433004
66MP0000751_myopathy0.86442118
67MP0002084_abnormal_developmental_patter0.83849237
68MP0000647_abnormal_sebaceous_gland0.83736144
69MP0000313_abnormal_cell_death0.83488013
70MP0000465_gastrointestinal_hemorrhage0.83407409
71MP0001835_abnormal_antigen_presentation0.82455847
72MP0005464_abnormal_platelet_physiology0.82259856
73MP0006036_abnormal_mitochondrial_physio0.82119205
74MP0003937_abnormal_limbs/digits/tail_de0.81226096
75MP0002080_prenatal_lethality0.79433898
76MP0003984_embryonic_growth_retardation0.77083548
77MP0003942_abnormal_urinary_system0.76397456
78MP0002932_abnormal_joint_morphology0.75387773
79MP0001929_abnormal_gametogenesis0.75121899
80MP0000955_abnormal_spinal_cord0.74388197
81MP0002735_abnormal_chemical_nociception0.74242564
82MP0004185_abnormal_adipocyte_glucose0.73965899
83MP0000598_abnormal_liver_morphology0.73731646
84MP0000003_abnormal_adipose_tissue0.71674932
85MP0002398_abnormal_bone_marrow0.71503562
86MP0002088_abnormal_embryonic_growth/wei0.70893499
87MP0005253_abnormal_eye_physiology0.70181411
88MP0001697_abnormal_embryo_size0.69742649
89MP0002234_abnormal_pharynx_morphology0.69630178
90MP0006138_congestive_heart_failure0.69134412
91MP0005380_embryogenesis_phenotype0.68580989
92MP0001672_abnormal_embryogenesis/_devel0.68580989
93MP0004264_abnormal_extraembryonic_tissu0.67096788
94MP0000639_abnormal_adrenal_gland0.66678744
95MP0000377_abnormal_hair_follicle0.66258446
96MP0002127_abnormal_cardiovascular_syste0.65721914
97MP0002161_abnormal_fertility/fecundity0.65219659
98MP0004782_abnormal_surfactant_physiolog0.65079281
99MP0001119_abnormal_female_reproductive0.63646777
100MP0003699_abnormal_female_reproductive0.62355210

Predicted human phenotypes

RankGene SetZ-score
1Ankle clonus (HP:0011448)3.47275895
2Abnormality of alanine metabolism (HP:0010916)3.45021961
3Hyperalaninemia (HP:0003348)3.45021961
4Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.45021961
5Tubulointerstitial nephritis (HP:0001970)3.43379591
6Spontaneous abortion (HP:0005268)3.40080610
7Thrombocytosis (HP:0001894)3.37122034
8Fibular aplasia (HP:0002990)3.05008547
9Concave nail (HP:0001598)2.98292812
10Hyperglycinuria (HP:0003108)2.91388521
11Sparse lateral eyebrow (HP:0005338)2.84218969
12Limb hypertonia (HP:0002509)2.65044311
13Lipid accumulation in hepatocytes (HP:0006561)2.59670851
14Papillary thyroid carcinoma (HP:0002895)2.58495606
15Abnormal gallbladder physiology (HP:0012438)2.56258028
16Cholecystitis (HP:0001082)2.56258028
17Increased intramyocellular lipid droplets (HP:0012240)2.55490559
18Lower limb muscle weakness (HP:0007340)2.53698128
19Reticulocytosis (HP:0001923)2.53144284
20Increased muscle lipid content (HP:0009058)2.49194706
21Cone-rod dystrophy (HP:0000548)2.42033645
22Abnormality of the prostate (HP:0008775)2.37956101
23Chronic hepatic failure (HP:0100626)2.35057311
24Hepatocellular necrosis (HP:0001404)2.34767193
25Brushfield spots (HP:0001088)2.34090865
26Acute lymphatic leukemia (HP:0006721)2.25862721
27Increased hepatocellular lipid droplets (HP:0006565)2.24684649
28Pancreatic fibrosis (HP:0100732)2.20262119
29Lower limb amyotrophy (HP:0007210)2.19042307
30Hip dysplasia (HP:0001385)2.18367775
31Hepatic necrosis (HP:0002605)2.17303286
32Chromsome breakage (HP:0040012)2.16194450
33Tented upper lip vermilion (HP:0010804)2.16097064
34Renal cortical cysts (HP:0000803)2.14996973
35Atelectasis (HP:0100750)2.14736999
36Bone marrow hypocellularity (HP:0005528)2.12404216
37Epidermoid cyst (HP:0200040)2.10618043
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.10573264
39Urinary urgency (HP:0000012)2.08905050
40Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07788245
41Entropion (HP:0000621)2.07462677
42Pancreatic cysts (HP:0001737)2.06636754
43Aplasia/Hypoplasia of the patella (HP:0006498)2.05975312
44Ketoacidosis (HP:0001993)2.04024833
45Spastic paraplegia (HP:0001258)2.03135769
46Coarctation of aorta (HP:0001680)2.00970130
47Broad alveolar ridges (HP:0000187)2.00462120
48Seborrheic dermatitis (HP:0001051)1.96529460
49True hermaphroditism (HP:0010459)1.94273961
50Type I transferrin isoform profile (HP:0003642)1.94011726
51Decreased central vision (HP:0007663)1.93303972
52Nephrogenic diabetes insipidus (HP:0009806)1.92209233
53Occipital encephalocele (HP:0002085)1.91465175
54Open mouth (HP:0000194)1.91253801
55Nephronophthisis (HP:0000090)1.90863146
56Abnormality of glycine metabolism (HP:0010895)1.89190354
57Abnormality of serine family amino acid metabolism (HP:0010894)1.89190354
5811 pairs of ribs (HP:0000878)1.89052330
59Progressive inability to walk (HP:0002505)1.88336530
60Hepatoblastoma (HP:0002884)1.88222644
61Embryonal neoplasm (HP:0002898)1.86059880
62Abnormal umbilical cord blood vessels (HP:0011403)1.85538055
63Single umbilical artery (HP:0001195)1.85538055
64Abnormality of the fetal cardiovascular system (HP:0010948)1.85538055
65Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.84935579
66Postaxial foot polydactyly (HP:0001830)1.84222695
67Asplenia (HP:0001746)1.83727247
68Glucose intolerance (HP:0000833)1.83524207
69Panhypogammaglobulinemia (HP:0003139)1.83470690
70Congenital primary aphakia (HP:0007707)1.82621332
71Myelodysplasia (HP:0002863)1.82328463
72Gait imbalance (HP:0002141)1.79605316
73Ketosis (HP:0001946)1.79071569
74Abolished electroretinogram (ERG) (HP:0000550)1.78520610
75Paraplegia (HP:0010550)1.78025956
76Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.77652420
77Abnormality of male internal genitalia (HP:0000022)1.76850891
78Heterotopia (HP:0002282)1.75441536
79Neurodegeneration (HP:0002180)1.75332569
80Amelogenesis imperfecta (HP:0000705)1.74264057
81Nephroblastoma (Wilms tumor) (HP:0002667)1.74183975
82Oculomotor apraxia (HP:0000657)1.73738793
83Abnormality of chloride homeostasis (HP:0011422)1.73341896
84Poor coordination (HP:0002370)1.73311580
85Dyschromatopsia (HP:0007641)1.72913074
86Cerebellar dysplasia (HP:0007033)1.72511964
87Peripheral hypomyelination (HP:0007182)1.69420959
88Long palpebral fissure (HP:0000637)1.69377599
89Hyperventilation (HP:0002883)1.69254050
90Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.68184988
91Acute myeloid leukemia (HP:0004808)1.66640168
92Renal Fanconi syndrome (HP:0001994)1.65222993
93Long clavicles (HP:0000890)1.64373913
94Patellar aplasia (HP:0006443)1.64241317
95Abnormality of the proximal phalanges of the hand (HP:0009834)1.63899696
96Thyroid carcinoma (HP:0002890)1.63277961
97Rhabdomyolysis (HP:0003201)1.62609078
98Short foot (HP:0001773)1.62591108
99Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.61775221
100Poikiloderma (HP:0001029)1.61648010

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK12.80187854
2PKN22.75262070
3PBK2.74001099
4SIK32.66406797
5TRIM282.54404256
6BCR2.49785916
7BRD42.40294918
8CDK122.39366056
9TRIB32.27483662
10TNK22.26773958
11GRK72.18622538
12SRPK12.10756191
13IRAK22.04158291
14TESK21.92721149
15FLT31.88707278
16PRKD31.86923239
17CSNK1A1L1.85929632
18MAP2K71.83403957
19CASK1.82490094
20MAP3K41.79386029
21EPHA31.78572451
22IRAK11.73329978
23BTK1.70799395
24PLK41.70447075
25CSNK1G31.61357381
26CSF1R1.58040160
27SCYL21.54274051
28BCKDK1.52570461
29ICK1.51795572
30AKT31.50323613
31STK161.50109187
32TEC1.39098010
33MAP3K71.34659543
34CDK61.32365873
35CHEK21.23927456
36SIK21.22588542
37MAP4K11.21694360
38PRKD21.21257630
39PIM21.16040854
40STK241.11723002
41CSNK1G21.11666291
42STK38L1.11503149
43CDK91.07316203
44PRPF4B1.03253809
45EIF2AK11.03243904
46WNK40.95014454
47IKBKE0.94883462
48CSNK1G10.94136371
49HCK0.91961716
50CDK40.88321937
51FES0.87428848
52CDK70.86993192
53ITK0.83576015
54RAF10.82836418
55IRAK40.82517485
56TBK10.80202725
57RET0.79947153
58CAMK1D0.78128353
59MAPK130.75591660
60MAP3K130.75109191
61ATR0.73474532
62MARK10.73394279
63MAPK110.71336074
64NEK90.71235869
65CAMKK10.70517588
66EEF2K0.68345031
67TAOK30.68190877
68GRK60.68072700
69SMG10.66915799
70KIT0.65202918
71MTOR0.63887837
72MAP4K20.63109093
73NME20.60213700
74JAK20.57662233
75CHEK10.55943423
76PDK10.51225969
77CDK20.50931423
78TSSK60.50711397
79ARAF0.50601690
80SYK0.49959479
81CAMKK20.48528088
82RPS6KB10.47272434
83DYRK20.46038354
84MAP3K60.45507288
85JAK30.45486925
86MAP2K40.44444318
87ATM0.43217473
88FER0.41820761
89AKT20.40461374
90STK380.40235502
91CAMK1G0.38835426
92PRKD10.38723459
93NEK60.36621854
94CLK10.35791142
95MAPK30.35534448
96RPS6KA40.35359750
97BRAF0.35071542
98CDK10.34892150
99PRKCQ0.34577914
100RPS6KC10.34002593

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009704.07502748
2Base excision repair_Homo sapiens_hsa034103.57408869
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.64955119
4Propanoate metabolism_Homo sapiens_hsa006402.46666529
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26855924
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.25240071
7Other glycan degradation_Homo sapiens_hsa005112.17522477
8mRNA surveillance pathway_Homo sapiens_hsa030152.17267252
9Acute myeloid leukemia_Homo sapiens_hsa052212.11742425
10Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.06018657
11Butanoate metabolism_Homo sapiens_hsa006502.03359230
12Non-small cell lung cancer_Homo sapiens_hsa052232.01703546
13Fanconi anemia pathway_Homo sapiens_hsa034601.95774222
14Non-homologous end-joining_Homo sapiens_hsa034501.94931886
15Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.89989811
16Chronic myeloid leukemia_Homo sapiens_hsa052201.87768265
17Basal transcription factors_Homo sapiens_hsa030221.86345362
18Lysine degradation_Homo sapiens_hsa003101.85816972
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68839219
20Biosynthesis of amino acids_Homo sapiens_hsa012301.65578144
21Carbon metabolism_Homo sapiens_hsa012001.58599869
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.53606480
23RNA transport_Homo sapiens_hsa030131.48788436
24Fatty acid elongation_Homo sapiens_hsa000621.47267868
25Pancreatic cancer_Homo sapiens_hsa052121.46286936
26Fatty acid metabolism_Homo sapiens_hsa012121.42930434
27mTOR signaling pathway_Homo sapiens_hsa041501.34723310
28Spliceosome_Homo sapiens_hsa030401.33158052
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31444028
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.24778768
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24682666
32Hepatitis B_Homo sapiens_hsa051611.19498391
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10601686
34Peroxisome_Homo sapiens_hsa041461.08884541
35Thyroid cancer_Homo sapiens_hsa052161.06922770
36Homologous recombination_Homo sapiens_hsa034401.06259256
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05895996
38Pentose phosphate pathway_Homo sapiens_hsa000301.04787612
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03172934
40Regulation of autophagy_Homo sapiens_hsa041400.99748110
41Colorectal cancer_Homo sapiens_hsa052100.95818734
42Viral carcinogenesis_Homo sapiens_hsa052030.93567226
43Choline metabolism in cancer_Homo sapiens_hsa052310.92550791
44Nucleotide excision repair_Homo sapiens_hsa034200.91309519
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90382845
46Glycerophospholipid metabolism_Homo sapiens_hsa005640.90212522
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86147805
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86044824
49Fatty acid biosynthesis_Homo sapiens_hsa000610.85043696
50Protein export_Homo sapiens_hsa030600.84810060
51Melanoma_Homo sapiens_hsa052180.81565568
52B cell receptor signaling pathway_Homo sapiens_hsa046620.80674116
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79363670
54Endometrial cancer_Homo sapiens_hsa052130.79055221
55Herpes simplex infection_Homo sapiens_hsa051680.78094973
56Cell cycle_Homo sapiens_hsa041100.76934566
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76478990
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74902127
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.74491987
60Inositol phosphate metabolism_Homo sapiens_hsa005620.74092455
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72680380
62Prolactin signaling pathway_Homo sapiens_hsa049170.70946048
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.68961498
64Insulin signaling pathway_Homo sapiens_hsa049100.65259542
65Pyrimidine metabolism_Homo sapiens_hsa002400.64779949
66Fructose and mannose metabolism_Homo sapiens_hsa000510.64722635
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.63823198
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63358653
69Hepatitis C_Homo sapiens_hsa051600.62277881
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61863832
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.59403324
72Alcoholism_Homo sapiens_hsa050340.59368645
73Pyruvate metabolism_Homo sapiens_hsa006200.58442345
74RNA degradation_Homo sapiens_hsa030180.56785385
75ErbB signaling pathway_Homo sapiens_hsa040120.54134032
76Phenylalanine metabolism_Homo sapiens_hsa003600.53739849
77Glioma_Homo sapiens_hsa052140.52941122
78Selenocompound metabolism_Homo sapiens_hsa004500.52387244
79Long-term depression_Homo sapiens_hsa047300.52278445
80Oocyte meiosis_Homo sapiens_hsa041140.50204200
81Bladder cancer_Homo sapiens_hsa052190.47936391
82Purine metabolism_Homo sapiens_hsa002300.47688699
83Sulfur relay system_Homo sapiens_hsa041220.47302411
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47096180
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44072037
86AMPK signaling pathway_Homo sapiens_hsa041520.44044215
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43392593
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43193112
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.42447919
90Type II diabetes mellitus_Homo sapiens_hsa049300.41181727
91ABC transporters_Homo sapiens_hsa020100.41033817
92Glycerolipid metabolism_Homo sapiens_hsa005610.37338507
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36539930
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.35806735
95Olfactory transduction_Homo sapiens_hsa047400.33547749
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.30396260
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30004633
98N-Glycan biosynthesis_Homo sapiens_hsa005100.29554705
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27937414
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27733801

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