WDR89

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)6.32664659
2viral transcription (GO:0019083)6.17030419
3ribosomal large subunit biogenesis (GO:0042273)6.06496541
4translational termination (GO:0006415)6.01511853
5maturation of SSU-rRNA (GO:0030490)5.34184652
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.15746424
7cotranslational protein targeting to membrane (GO:0006613)5.08241703
8protein targeting to ER (GO:0045047)5.06159723
9translational elongation (GO:0006414)5.05351314
10proteasome assembly (GO:0043248)4.99480898
11ribosomal small subunit assembly (GO:0000028)4.88327084
12DNA double-strand break processing (GO:0000729)4.88131057
13translational initiation (GO:0006413)4.83915083
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.79362151
15DNA deamination (GO:0045006)4.77985802
16ribonucleoprotein complex biogenesis (GO:0022613)4.76683641
17protein localization to endoplasmic reticulum (GO:0070972)4.75169088
18cellular protein complex disassembly (GO:0043624)4.74470401
19transcription elongation from RNA polymerase III promoter (GO:0006385)4.60945396
20termination of RNA polymerase III transcription (GO:0006386)4.60945396
21viral life cycle (GO:0019058)4.60594780
22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.59840833
23DNA replication checkpoint (GO:0000076)4.52640104
24DNA damage response, detection of DNA damage (GO:0042769)4.36818472
25spliceosomal snRNP assembly (GO:0000387)4.24994647
26protein complex disassembly (GO:0043241)4.08854807
27translation (GO:0006412)4.07674024
28spliceosomal complex assembly (GO:0000245)3.97179902
29rRNA processing (GO:0006364)3.96224766
30telomere maintenance via semi-conservative replication (GO:0032201)3.96143333
31regulation of nuclear cell cycle DNA replication (GO:0033262)3.95304431
32histone exchange (GO:0043486)3.90300081
33macromolecular complex disassembly (GO:0032984)3.89152800
34rRNA metabolic process (GO:0016072)3.83922270
35regulation of mitotic spindle checkpoint (GO:1903504)3.79665190
36regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.79665190
37metaphase plate congression (GO:0051310)3.79366822
38DNA strand elongation involved in DNA replication (GO:0006271)3.78996518
39ribosome assembly (GO:0042255)3.76777196
40cellular component biogenesis (GO:0044085)3.73404307
41ribosome biogenesis (GO:0042254)3.73243592
42nuclear pore organization (GO:0006999)3.70943561
43rRNA modification (GO:0000154)3.68606807
44attachment of spindle microtubules to kinetochore (GO:0008608)3.67673279
45DNA replication initiation (GO:0006270)3.64915977
46regulation of centriole replication (GO:0046599)3.63416005
47CENP-A containing nucleosome assembly (GO:0034080)3.60991217
48negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.60836596
49negative regulation of translation, ncRNA-mediated (GO:0040033)3.60836596
50regulation of translation, ncRNA-mediated (GO:0045974)3.60836596
51DNA strand elongation (GO:0022616)3.60401740
52cullin deneddylation (GO:0010388)3.58828202
53mitotic sister chromatid cohesion (GO:0007064)3.58079921
54L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.54170952
55mitochondrial DNA replication (GO:0006264)3.51421744
56IMP biosynthetic process (GO:0006188)3.51186458
57telomere maintenance via recombination (GO:0000722)3.50594753
58kinetochore assembly (GO:0051382)3.50394442
59chromatin remodeling at centromere (GO:0031055)3.50114367
60somatic hypermutation of immunoglobulin genes (GO:0016446)3.48372315
61somatic diversification of immune receptors via somatic mutation (GO:0002566)3.48372315
62deoxyribonucleotide biosynthetic process (GO:0009263)3.47136907
63pseudouridine synthesis (GO:0001522)3.43273877
64nuclear-transcribed mRNA catabolic process (GO:0000956)3.42954616
65DNA catabolic process, exonucleolytic (GO:0000738)3.42835692
66purine nucleobase biosynthetic process (GO:0009113)3.42322427
67double-strand break repair via nonhomologous end joining (GO:0006303)3.41280775
68non-recombinational repair (GO:0000726)3.41280775
69spindle checkpoint (GO:0031577)3.41066059
70sister chromatid segregation (GO:0000819)3.38918704
71regulation of double-strand break repair via homologous recombination (GO:0010569)3.38491157
72mitochondrial RNA metabolic process (GO:0000959)3.38468763
73regulation of helicase activity (GO:0051095)3.37727089
74mitotic spindle checkpoint (GO:0071174)3.37676963
75telomere maintenance via telomere lengthening (GO:0010833)3.36427276
76deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.34001850
77replication fork processing (GO:0031297)3.33931281
78maturation of 5.8S rRNA (GO:0000460)3.33598599
79centriole replication (GO:0007099)3.32235420
80kinetochore organization (GO:0051383)3.29316307
81transcription-coupled nucleotide-excision repair (GO:0006283)3.27688562
82regulation of DNA endoreduplication (GO:0032875)3.27602680
83DNA replication-dependent nucleosome organization (GO:0034723)3.27242181
84DNA replication-dependent nucleosome assembly (GO:0006335)3.27242181
85mRNA catabolic process (GO:0006402)3.25655571
86negative regulation of DNA recombination (GO:0045910)3.25046452
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.24652483
88mitotic recombination (GO:0006312)3.23760661
89protein targeting to membrane (GO:0006612)3.23686400
90folic acid-containing compound biosynthetic process (GO:0009396)3.23386634
91RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.22571444
92mitotic metaphase plate congression (GO:0007080)3.22406227
93mitotic sister chromatid segregation (GO:0000070)3.21768947
94protein deneddylation (GO:0000338)3.21722423
95DNA-dependent DNA replication (GO:0006261)3.21076140
96negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.20600467
97negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.20600467
98negative regulation of mitotic sister chromatid segregation (GO:0033048)3.20600467
99negative regulation of mitotic sister chromatid separation (GO:2000816)3.20600467
100negative regulation of sister chromatid segregation (GO:0033046)3.20600467
101negative regulation of DNA-dependent DNA replication (GO:2000104)3.20313725
1027-methylguanosine mRNA capping (GO:0006370)3.19663638
103transcription from RNA polymerase I promoter (GO:0006360)3.18424173
104RNA capping (GO:0036260)3.14993337
1057-methylguanosine RNA capping (GO:0009452)3.14993337
106negative regulation of chromosome segregation (GO:0051985)3.12225985
107anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.11862849
108nuclear pore complex assembly (GO:0051292)3.11792649
109recombinational repair (GO:0000725)3.11084278
110regulation of centrosome cycle (GO:0046605)3.10844194
111double-strand break repair via homologous recombination (GO:0000724)3.10534473
112resolution of meiotic recombination intermediates (GO:0000712)3.10439789
113RNA catabolic process (GO:0006401)3.09946864
114protein localization to kinetochore (GO:0034501)3.09597500
115positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.09273839
116transcription from mitochondrial promoter (GO:0006390)3.08721398
117amino acid salvage (GO:0043102)3.08021077
118L-methionine salvage (GO:0071267)3.08021077
119L-methionine biosynthetic process (GO:0071265)3.08021077
120regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.07203462
121establishment of integrated proviral latency (GO:0075713)3.06676370
122reciprocal DNA recombination (GO:0035825)3.06260593
123reciprocal meiotic recombination (GO:0007131)3.06260593
124mitotic spindle assembly checkpoint (GO:0007094)3.05560289
125IMP metabolic process (GO:0046040)3.05362715
126transcription elongation from RNA polymerase I promoter (GO:0006362)3.05339213
127termination of RNA polymerase I transcription (GO:0006363)3.04356638
128regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.03968720
129rRNA methylation (GO:0031167)3.03670691
130regulation of centrosome duplication (GO:0010824)3.02819273
131response to pheromone (GO:0019236)3.02561651
132ncRNA processing (GO:0034470)3.01067390
133nucleobase-containing small molecule interconversion (GO:0015949)3.00704841
134histone mRNA metabolic process (GO:0008334)2.99885206
135spindle assembly checkpoint (GO:0071173)2.99688386
136DNA ligation (GO:0006266)2.99100619
137regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.98331964
138regulation of mitotic metaphase/anaphase transition (GO:0030071)2.98331964
139somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.97205892
140isotype switching (GO:0045190)2.97205892
141somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.97205892
142tRNA modification (GO:0006400)2.95758722
143DNA replication-independent nucleosome organization (GO:0034724)2.95562985
144DNA replication-independent nucleosome assembly (GO:0006336)2.95562985
145negative regulation of ligase activity (GO:0051352)2.95434015
146negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.95434015
147exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93965815
148regulation of sister chromatid segregation (GO:0033045)2.93362503
149regulation of mitotic sister chromatid separation (GO:0010965)2.93362503
150regulation of mitotic sister chromatid segregation (GO:0033047)2.93362503
151DNA-templated transcription, termination (GO:0006353)2.92407422
152nucleotide-excision repair, DNA gap filling (GO:0006297)2.92228638
153GTP biosynthetic process (GO:0006183)2.89296426
154deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.86860972
155viral mRNA export from host cell nucleus (GO:0046784)2.86085595
156regulation of meiosis I (GO:0060631)2.85339672
157ncRNA metabolic process (GO:0034660)2.85006727
158mitotic nuclear envelope disassembly (GO:0007077)2.83895677
159protein-cofactor linkage (GO:0018065)2.82644364
160regulation of telomere maintenance via telomerase (GO:0032210)2.80992229
161deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.80646912
162nucleobase biosynthetic process (GO:0046112)2.80494712
163neural tube formation (GO:0001841)2.80435432
164establishment of chromosome localization (GO:0051303)2.80302710
165tRNA methylation (GO:0030488)2.79351666
166iron-sulfur cluster assembly (GO:0016226)2.79341604
167metallo-sulfur cluster assembly (GO:0031163)2.79341604
168nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78354289
169postreplication repair (GO:0006301)2.78289749
170tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.77985484
171RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.77985484
172histone H2A acetylation (GO:0043968)2.76397517
173double-strand break repair (GO:0006302)2.74376241
174somatic recombination of immunoglobulin gene segments (GO:0016447)2.71934757
175water-soluble vitamin biosynthetic process (GO:0042364)2.71743223
176prenylation (GO:0097354)2.69410985
177protein prenylation (GO:0018342)2.69410985
178telomere maintenance via telomerase (GO:0007004)2.69128555
179regulation of chromosome segregation (GO:0051983)2.68112026
180maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.68050636

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.28817775
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.71239187
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.28341161
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.68519320
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.59202980
6* ETS1_20019798_ChIP-Seq_JURKAT_Human3.48751590
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.48295278
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.45783752
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.37924480
10SALL1_21062744_ChIP-ChIP_HESCs_Human3.32166878
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.29748218
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.20865706
13FOXM1_23109430_ChIP-Seq_U2OS_Human3.17182534
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.12195008
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.08902817
16MYC_18358816_ChIP-ChIP_MESCs_Mouse3.05933268
17MYC_19030024_ChIP-ChIP_MESCs_Mouse3.05590774
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.96990744
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.76890045
20ZNF274_21170338_ChIP-Seq_K562_Hela2.72008137
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.63398462
22* XRN2_22483619_ChIP-Seq_HELA_Human2.61185421
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.59975170
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.56480389
25EWS_26573619_Chip-Seq_HEK293_Human2.50722261
26VDR_23849224_ChIP-Seq_CD4+_Human2.50481378
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.49301193
28IGF1R_20145208_ChIP-Seq_DFB_Human2.45778433
29POU3F2_20337985_ChIP-ChIP_501MEL_Human2.42710889
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.37896462
31VDR_22108803_ChIP-Seq_LS180_Human2.34687110
32DCP1A_22483619_ChIP-Seq_HELA_Human2.33571294
33KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.33454107
34KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.33454107
35KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.33454107
36TTF2_22483619_ChIP-Seq_HELA_Human2.32158586
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24457005
38E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22866690
39FUS_26573619_Chip-Seq_HEK293_Human2.22654210
40NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19976266
41FOXP3_21729870_ChIP-Seq_TREG_Human2.16031185
42ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12994439
43FLI1_27457419_Chip-Seq_LIVER_Mouse2.06266707
44THAP11_20581084_ChIP-Seq_MESCs_Mouse2.02595763
45ELK1_19687146_ChIP-ChIP_HELA_Human1.96813503
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95700076
47TAF15_26573619_Chip-Seq_HEK293_Human1.94818432
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88308408
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.82257239
50P300_19829295_ChIP-Seq_ESCs_Human1.81117027
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.80624379
52GBX2_23144817_ChIP-Seq_PC3_Human1.78449646
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.76534258
54GABP_19822575_ChIP-Seq_HepG2_Human1.75415631
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70583866
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.68704087
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67170679
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66336842
59KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.64971926
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64862935
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.64701143
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64483039
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62822297
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61107092
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59880353
66* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58227200
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56709293
68ELK1_22589737_ChIP-Seq_MCF10A_Human1.54977265
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.47771095
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44063185
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43450626
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43417018
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42889205
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.41941622
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.41808767
76IRF1_19129219_ChIP-ChIP_H3396_Human1.41695451
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39210988
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37908671
79* ER_23166858_ChIP-Seq_MCF-7_Human1.36596950
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35612833
81AR_21909140_ChIP-Seq_LNCAP_Human1.33202462
82* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33097084
83MYC_18940864_ChIP-ChIP_HL60_Human1.30888432
84* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27629732
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27439713
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26333877
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25359418
88* KDM5A_27292631_Chip-Seq_BREAST_Human1.22200283
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21894320
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.20324751
91SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.20134623
92CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19992178
93SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18903260
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16669804
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16406025
96SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15902627
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15760210
98CBP_20019798_ChIP-Seq_JUKART_Human1.15760210
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14049872
100* STAT3_23295773_ChIP-Seq_U87_Human1.13438492
101PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12021424
102* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11469535
103PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11349450
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11203089
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10718971
106SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10626243
107* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10604631
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09629823
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07740940
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06743954
111CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06528855
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.05835640
113TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05668190
114CIITA_25753668_ChIP-Seq_RAJI_Human1.05582686
115KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05184671
116POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04815890
117SMAD4_21799915_ChIP-Seq_A2780_Human1.03515170
118TP53_22573176_ChIP-Seq_HFKS_Human1.02449225
119STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02427133
120SOX2_16153702_ChIP-ChIP_HESCs_Human1.01453821
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99731888
122NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.99433016
123NANOG_16153702_ChIP-ChIP_HESCs_Human0.99211844
124TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99178273
125* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99157545
126KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99077379
127ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97945441
128BCAT_22108803_ChIP-Seq_LS180_Human0.96942602
129SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96241634
130SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95374253
131RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95185044
132TCF4_23295773_ChIP-Seq_U87_Human0.94934127
133SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94501183
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94394023
135CRX_20693478_ChIP-Seq_RETINA_Mouse0.93849167
136NANOG_18555785_Chip-Seq_ESCs_Mouse0.93580361
137CDX2_22108803_ChIP-Seq_LS180_Human0.93195973
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93032425
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92878941
140* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91113887
141BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90897824
142TCF4_22108803_ChIP-Seq_LS180_Human0.90753373
143KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90310746
144CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89696779
145PIAS1_25552417_ChIP-Seq_VCAP_Human0.89422651
146SOX17_20123909_ChIP-Seq_XEN_Mouse0.87597349
147OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86708175
148SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86243985
149HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83001635
150NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.76222629
151POU5F1_16153702_ChIP-ChIP_HESCs_Human0.75329390
152SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.72402201
153* SPI1_23547873_ChIP-Seq_NB4_Human0.70606805
154NANOG_18692474_ChIP-Seq_MEFs_Mouse0.69883466
155CTCF_18555785_ChIP-Seq_MESCs_Mouse0.69825822
156FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69030361

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.54706966
2MP0003693_abnormal_embryo_hatching4.27389319
3MP0003111_abnormal_nucleus_morphology3.53515940
4MP0004957_abnormal_blastocyst_morpholog3.43693899
5MP0008932_abnormal_embryonic_tissue3.32399329
6MP0010094_abnormal_chromosome_stability3.19924497
7MP0003136_yellow_coat_color2.88936217
8MP0003077_abnormal_cell_cycle2.87941201
9MP0008007_abnormal_cellular_replicative2.79486334
10MP0003941_abnormal_skin_development2.76667738
11MP0001188_hyperpigmentation2.71869870
12MP0008058_abnormal_DNA_repair2.66814825
13MP0008057_abnormal_DNA_replication2.54708399
14MP0003786_premature_aging2.42648713
15MP0010030_abnormal_orbit_morphology2.41087799
16MP0003718_maternal_effect2.35206863
17MP0009697_abnormal_copulation2.33736984
18MP0004381_abnormal_hair_follicle2.25124329
19MP0006292_abnormal_olfactory_placode2.21880339
20MP0006072_abnormal_retinal_apoptosis2.07561622
21MP0000569_abnormal_digit_pigmentation2.03939883
22MP0000566_synostosis1.87220987
23MP0003315_abnormal_perineum_morphology1.85264920
24MP0001529_abnormal_vocalization1.84382507
25MP0002160_abnormal_reproductive_system1.69053157
26MP0004147_increased_porphyrin_level1.60329160
27MP0002277_abnormal_respiratory_mucosa1.56500031
28MP0001919_abnormal_reproductive_system1.53576764
29MP0002102_abnormal_ear_morphology1.48966333
30MP0000049_abnormal_middle_ear1.48685949
31MP0005409_darkened_coat_color1.48474851
32MP0002736_abnormal_nociception_after1.47872388
33MP0001986_abnormal_taste_sensitivity1.47456738
34MP0000350_abnormal_cell_proliferation1.45904043
35MP0002254_reproductive_system_inflammat1.44230903
36MP0005389_reproductive_system_phenotype1.42661416
37MP0003195_calcinosis1.42642062
38MP0002837_dystrophic_cardiac_calcinosis1.41946933
39MP0005253_abnormal_eye_physiology1.41562813
40MP0001485_abnormal_pinna_reflex1.39355313
41MP0000427_abnormal_hair_cycle1.35375644
42MP0001984_abnormal_olfaction1.35299760
43MP0003938_abnormal_ear_development1.32731324
44MP0006035_abnormal_mitochondrial_morpho1.32054594
45MP0002233_abnormal_nose_morphology1.31319159
46MP0008877_abnormal_DNA_methylation1.30561710
47MP0008995_early_reproductive_senescence1.28471601
48MP0002210_abnormal_sex_determination1.25407730
49MP0000631_abnormal_neuroendocrine_gland1.24963029
50MP0003724_increased_susceptibility_to1.22921968
51MP0001542_abnormal_bone_strength1.21978543
52MP0000613_abnormal_salivary_gland1.21725019
53MP0002132_abnormal_respiratory_system1.21695229
54MP0005551_abnormal_eye_electrophysiolog1.19797179
55MP0003121_genomic_imprinting1.18181338
56MP0003937_abnormal_limbs/digits/tail_de1.17624645
57MP0009053_abnormal_anal_canal1.16732083
58MP0005499_abnormal_olfactory_system1.16663497
59MP0005394_taste/olfaction_phenotype1.16663497
60MP0001764_abnormal_homeostasis1.15081735
61MP0009250_abnormal_appendicular_skeleto1.13951510
62MP0001730_embryonic_growth_arrest1.13177684
63MP0009333_abnormal_splenocyte_physiolog1.11655229
64MP0002085_abnormal_embryonic_tissue1.09947160
65MP0000647_abnormal_sebaceous_gland1.09667070
66MP0000490_abnormal_crypts_of1.08434039
67MP0001697_abnormal_embryo_size1.08084120
68MP0004133_heterotaxia1.07607163
69MP0000313_abnormal_cell_death1.07390723
70MP0005257_abnormal_intraocular_pressure1.06158491
71MP0001145_abnormal_male_reproductive1.04532469
72MP0002751_abnormal_autonomic_nervous1.03922933
73MP0005075_abnormal_melanosome_morpholog1.03419751
74MP0003698_abnormal_male_reproductive1.03033344
75MP0002249_abnormal_larynx_morphology1.03027306
76MP0005367_renal/urinary_system_phenotyp1.01697110
77MP0000516_abnormal_urinary_system1.01697110
78MP0001286_abnormal_eye_development1.00721684
79MP0001672_abnormal_embryogenesis/_devel0.98778324
80MP0005380_embryogenesis_phenotype0.98778324
81MP0000383_abnormal_hair_follicle0.98547757
82MP0003806_abnormal_nucleotide_metabolis0.98505864
83MP0003936_abnormal_reproductive_system0.97871345
84MP0000762_abnormal_tongue_morphology0.97556389
85MP0003119_abnormal_digestive_system0.97504997
86MP0002111_abnormal_tail_morphology0.97154557
87MP0005174_abnormal_tail_pigmentation0.96178963
88MP0003011_delayed_dark_adaptation0.96006935
89MP0002177_abnormal_outer_ear0.94650183
90MP0010307_abnormal_tumor_latency0.94465365
91MP0003755_abnormal_palate_morphology0.93777179
92MP0003646_muscle_fatigue0.93325918
93MP0003385_abnormal_body_wall0.92985912
94MP0001293_anophthalmia0.92879994
95MP0002080_prenatal_lethality0.92660170
96MP0004197_abnormal_fetal_growth/weight/0.91901128
97MP0004185_abnormal_adipocyte_glucose0.91387889
98MP0005646_abnormal_pituitary_gland0.90427166
99MP0002234_abnormal_pharynx_morphology0.90209467
100MP0005379_endocrine/exocrine_gland_phen0.90009207
101MP0003567_abnormal_fetal_cardiomyocyte0.89934020
102MP0003787_abnormal_imprinting0.89719071
103MP0000858_altered_metastatic_potential0.88624939
104MP0000372_irregular_coat_pigmentation0.87925409
105MP0003828_pulmonary_edema0.87588612
106MP0000653_abnormal_sex_gland0.87153502
107MP0008872_abnormal_physiological_respon0.86473357
108MP0005391_vision/eye_phenotype0.86221769
109MP0009703_decreased_birth_body0.85645689
110MP0006036_abnormal_mitochondrial_physio0.85395081
111MP0002095_abnormal_skin_pigmentation0.85094645
112MP0000703_abnormal_thymus_morphology0.84566887
113MP0003303_peritoneal_inflammation0.84168497
114MP0002163_abnormal_gland_morphology0.83349283
115MP0001968_abnormal_touch/_nociception0.83042214
116MP0001119_abnormal_female_reproductive0.82493823
117MP0003221_abnormal_cardiomyocyte_apopto0.81828407
118MP0005084_abnormal_gallbladder_morpholo0.81236704
119MP0008789_abnormal_olfactory_epithelium0.81217571
120MP0002019_abnormal_tumor_incidence0.80604199
121MP0000015_abnormal_ear_pigmentation0.80073087
122MP0000428_abnormal_craniofacial_morphol0.79971572
123MP0003186_abnormal_redox_activity0.79459207
124MP0000358_abnormal_cell_content/0.79434381
125MP0003763_abnormal_thymus_physiology0.78962177
126MP0000678_abnormal_parathyroid_gland0.78037680
127MP0005501_abnormal_skin_physiology0.77761798
128MP0004215_abnormal_myocardial_fiber0.77039752
129MP0004142_abnormal_muscle_tone0.76606913
130MP0000432_abnormal_head_morphology0.75546442
131MP0005410_abnormal_fertilization0.74912857
132MP0002088_abnormal_embryonic_growth/wei0.74446177
133MP0003880_abnormal_central_pattern0.74031471
134MP0003984_embryonic_growth_retardation0.73572967
135MP0003123_paternal_imprinting0.73498126
136MP0001929_abnormal_gametogenesis0.72806095
137MP0009046_muscle_twitch0.72758108
138MP0001346_abnormal_lacrimal_gland0.71941667
139MP0009672_abnormal_birth_weight0.71564963
140MP0005395_other_phenotype0.71187833
141MP0002084_abnormal_developmental_patter0.70381080
142MP0005171_absent_coat_pigmentation0.68327886
143MP0002938_white_spotting0.65411611
144MP0000627_abnormal_mammary_gland0.64669197
145MP0003890_abnormal_embryonic-extraembry0.63150088
146MP0000467_abnormal_esophagus_morphology0.62781872

Predicted human phenotypes

RankGene SetZ-score
1Progressive external ophthalmoplegia (HP:0000590)5.20049569
2Reticulocytopenia (HP:0001896)5.18500902
3Breast hypoplasia (HP:0003187)5.12385995
4Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.52380569
5Macrocytic anemia (HP:0001972)4.33690867
6Aplasia/Hypoplasia of the sacrum (HP:0008517)4.19073507
7Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.91611028
8Birth length less than 3rd percentile (HP:0003561)3.70773473
9Volvulus (HP:0002580)3.57788524
10Concave nail (HP:0001598)3.56563939
11Pallor (HP:0000980)3.44115293
12Abnormal hemoglobin (HP:0011902)3.34088503
13Triphalangeal thumb (HP:0001199)3.24828390
14Colon cancer (HP:0003003)3.21469318
15Cerebral hypomyelination (HP:0006808)3.08913461
16Pancreatic cysts (HP:0001737)3.06382108
17Absent radius (HP:0003974)3.06079730
18Microvesicular hepatic steatosis (HP:0001414)3.02869495
19Meckel diverticulum (HP:0002245)2.91906082
20Trismus (HP:0000211)2.91475915
21Abnormality of cells of the erythroid lineage (HP:0012130)2.90751058
22Aplasia involving forearm bones (HP:0009822)2.89777518
23Absent forearm bone (HP:0003953)2.89777518
24Congenital, generalized hypertrichosis (HP:0004540)2.88000163
25Aplasia/Hypoplasia of the patella (HP:0006498)2.87448890
26Patellar aplasia (HP:0006443)2.86922295
27Progressive muscle weakness (HP:0003323)2.85523975
28Absent thumb (HP:0009777)2.83358005
29Intestinal atresia (HP:0011100)2.81672451
30Rough bone trabeculation (HP:0100670)2.78995952
31Carpal bone hypoplasia (HP:0001498)2.78935765
32Pancreatic fibrosis (HP:0100732)2.77819207
33Secondary amenorrhea (HP:0000869)2.77063354
34Horseshoe kidney (HP:0000085)2.74161230
35Abnormality of alanine metabolism (HP:0010916)2.70500889
36Hyperalaninemia (HP:0003348)2.70500889
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.70500889
38Abnormality of the ileum (HP:0001549)2.70372721
39Methylmalonic acidemia (HP:0002912)2.67814703
40Abnormal number of erythroid precursors (HP:0012131)2.65182593
41True hermaphroditism (HP:0010459)2.63267807
42Aplasia/Hypoplasia involving the musculature (HP:0001460)2.57751029
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.56447128
44Chromsome breakage (HP:0040012)2.54984437
45Cleft eyelid (HP:0000625)2.54163644
46Increased hepatocellular lipid droplets (HP:0006565)2.54118507
47Nephronophthisis (HP:0000090)2.53283367
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52965449
49Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52965449
50Molar tooth sign on MRI (HP:0002419)2.52513591
51Abnormality of midbrain morphology (HP:0002418)2.52513591
52Aplasia/hypoplasia of the uterus (HP:0008684)2.49994709
53Progressive inability to walk (HP:0002505)2.49686674
54Hyperglycinemia (HP:0002154)2.49162554
55Abnormality of the preputium (HP:0100587)2.49102925
56Mitochondrial inheritance (HP:0001427)2.48996449
57Sloping forehead (HP:0000340)2.47763675
58Hepatocellular necrosis (HP:0001404)2.47506081
593-Methylglutaconic aciduria (HP:0003535)2.46063961
60Chronic hepatic failure (HP:0100626)2.45310991
61Exertional dyspnea (HP:0002875)2.45077554
62Increased serum lactate (HP:0002151)2.44277998
63Abnormal lung lobation (HP:0002101)2.42862171
64Hypoplasia of the radius (HP:0002984)2.40313351
65Testicular atrophy (HP:0000029)2.39639892
66Sparse lateral eyebrow (HP:0005338)2.38382891
67Small intestinal stenosis (HP:0012848)2.33437408
68Duodenal stenosis (HP:0100867)2.33437408
69Abnormality of methionine metabolism (HP:0010901)2.33307379
70External ophthalmoplegia (HP:0000544)2.32567311
71Granulocytopenia (HP:0001913)2.31010843
72Aplasia/Hypoplasia of the earlobes (HP:0009906)2.29182957
73Supernumerary spleens (HP:0009799)2.27341024
74Sparse eyelashes (HP:0000653)2.27161342
75Abnormality of the labia minora (HP:0012880)2.23538201
76Abnormality of the duodenum (HP:0002246)2.21953241
77Aplasia/Hypoplasia of the uvula (HP:0010293)2.20927486
78Exercise intolerance (HP:0003546)2.20600095
79Abnormality of the renal medulla (HP:0100957)2.20346717
80Nephroblastoma (Wilms tumor) (HP:0002667)2.19341107
81Premature graying of hair (HP:0002216)2.17989172
82Embryonal renal neoplasm (HP:0011794)2.16865837
83Increased CSF lactate (HP:0002490)2.16106674
84Constricted visual fields (HP:0001133)2.15488613
85Tubulointerstitial nephritis (HP:0001970)2.15481736
86Acute necrotizing encephalopathy (HP:0006965)2.15119255
87Abnormality of serum amino acid levels (HP:0003112)2.13490869
88Rhabdomyosarcoma (HP:0002859)2.12928626
89Abnormality of the anterior horn cell (HP:0006802)2.12879573
90Degeneration of anterior horn cells (HP:0002398)2.12879573
91Abnormality of the renal cortex (HP:0011035)2.12606803
92Methylmalonic aciduria (HP:0012120)2.12259533
93Abnormality of abdominal situs (HP:0011620)2.11033682
94Abdominal situs inversus (HP:0003363)2.11033682
95Renal Fanconi syndrome (HP:0001994)2.10198295
96Oral leukoplakia (HP:0002745)2.09965292
97Aplasia/Hypoplasia of the tibia (HP:0005772)2.09730361
98Obstructive sleep apnea (HP:0002870)2.09648645
99Medial flaring of the eyebrow (HP:0010747)2.07198441
100Abnormal trabecular bone morphology (HP:0100671)2.07072094
101Gaze-evoked nystagmus (HP:0000640)2.06231460
102Gonadotropin excess (HP:0000837)2.06122769
103Ependymoma (HP:0002888)2.05733518
104Abnormality of chromosome stability (HP:0003220)2.04999187
105Stenosis of the external auditory canal (HP:0000402)2.03401782
106Inability to walk (HP:0002540)2.02615932
107Reduced antithrombin III activity (HP:0001976)2.02062584
108Oligodactyly (hands) (HP:0001180)2.01939251
109Type I transferrin isoform profile (HP:0003642)2.01848868
110Adrenal hypoplasia (HP:0000835)2.01144091
111Aplasia/Hypoplasia of the tongue (HP:0010295)1.99822904
112Impulsivity (HP:0100710)1.98757198
113Renal cortical cysts (HP:0000803)1.98282990
114Abnormality of dental color (HP:0011073)1.98056719
115Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.98001457
116Seborrheic dermatitis (HP:0001051)1.97910388
117Small hand (HP:0200055)1.96850419
118Duplicated collecting system (HP:0000081)1.96534269
119Aplasia/Hypoplasia of the breasts (HP:0010311)1.96476402
120Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.95455330
121Atresia of the external auditory canal (HP:0000413)1.95211278
122Lipid accumulation in hepatocytes (HP:0006561)1.95190699
123Pendular nystagmus (HP:0012043)1.95160225
124Depressed nasal ridge (HP:0000457)1.94768822
125Oligodactyly (HP:0012165)1.94446018
126Abnormality of aspartate family amino acid metabolism (HP:0010899)1.94364176
127Biliary tract neoplasm (HP:0100574)1.93153393
128Clubbing of toes (HP:0100760)1.92187228
129Bifid tongue (HP:0010297)1.91900862
130Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90759581
131Abnormal protein N-linked glycosylation (HP:0012347)1.90759581
132Abnormal protein glycosylation (HP:0012346)1.90759581
133Abnormal glycosylation (HP:0012345)1.90759581
134Upper limb muscle weakness (HP:0003484)1.89404001
135Hepatic necrosis (HP:0002605)1.89287804
136Abolished electroretinogram (ERG) (HP:0000550)1.89200229
137Abnormality of glycine metabolism (HP:0010895)1.86801205
138Abnormality of serine family amino acid metabolism (HP:0010894)1.86801205
139Premature ovarian failure (HP:0008209)1.85129331
140Pancytopenia (HP:0001876)1.84713261
141Ectopic kidney (HP:0000086)1.84322112
142Dandy-Walker malformation (HP:0001305)1.82747081
143Bone marrow hypocellularity (HP:0005528)1.82597752
144Gastrointestinal atresia (HP:0002589)1.82363672
145Abnormality of the carotid arteries (HP:0005344)1.82032404
146Premature rupture of membranes (HP:0001788)1.81721180
147Supernumerary bones of the axial skeleton (HP:0009144)1.81568949
148Breast aplasia (HP:0100783)1.79919185
149Increased serum pyruvate (HP:0003542)1.79894882
150Abnormality of glycolysis (HP:0004366)1.79894882
151Aplastic anemia (HP:0001915)1.79667958
152Neoplasm of the pancreas (HP:0002894)1.79652160
153Redundant skin (HP:0001582)1.79539481
154Attenuation of retinal blood vessels (HP:0007843)1.78902372
155Congenital primary aphakia (HP:0007707)1.77603279
156Abnormal mitochondria in muscle tissue (HP:0008316)1.77091136
157Short tibia (HP:0005736)1.76973913
158Glucose intolerance (HP:0000833)1.76488118
159Optic disc pallor (HP:0000543)1.75715307
160Neoplasm of the adrenal cortex (HP:0100641)1.75658707
161Median cleft lip (HP:0000161)1.75177823
162Eosinophilia (HP:0001880)1.74723607
163Genital tract atresia (HP:0001827)1.74685646
164Conical tooth (HP:0000698)1.73816416
165Anencephaly (HP:0002323)1.73473818
166Central scotoma (HP:0000603)1.72906359
167Neoplasm of the colon (HP:0100273)1.72494960
168Acute encephalopathy (HP:0006846)1.72480719
169Hypoplasia of the pons (HP:0012110)1.71911068
170Myelodysplasia (HP:0002863)1.71853108
171Hyperglycinuria (HP:0003108)1.70980017
172Glioma (HP:0009733)1.70183118
173Sclerocornea (HP:0000647)1.69685819
174Preaxial hand polydactyly (HP:0001177)1.69545155
175Abnormal biliary tract physiology (HP:0012439)1.68616192
176Bile duct proliferation (HP:0001408)1.68616192
177Abnormality of the pons (HP:0007361)1.66121072
178Astigmatism (HP:0000483)1.65144133
179Long clavicles (HP:0000890)1.64469116
180Pancreatic islet-cell hyperplasia (HP:0004510)1.63822083
181Gait imbalance (HP:0002141)1.63547978

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.00110233
2EIF2AK14.94918047
3BUB14.76994910
4IRAK34.28152153
5FRK3.43726833
6PLK43.42915857
7NEK13.27862962
8SRPK12.90848881
9STK162.74678991
10WEE12.70883160
11TESK22.64752871
12MKNK22.46682747
13TRIM282.45213029
14IRAK42.41081932
15WNK32.38938035
16NME22.22726650
17ZAK2.17331711
18IRAK22.12942658
19IRAK12.01313964
20TNIK1.99695144
21TSSK61.91186208
22MKNK11.76535603
23LATS11.76122011
24NEK91.72460323
25TTK1.68588444
26BCR1.66390477
27EPHA21.65596177
28MAP4K21.61843441
29EIF2AK31.49486840
30PBK1.48116523
31DYRK31.47562772
32VRK11.34514105
33PLK21.33445943
34STK31.32664350
35MAP3K41.32632315
36PLK11.32370243
37ERBB31.32248103
38MARK11.32031831
39CASK1.31100179
40NME11.30392394
41PIM21.29324860
42VRK21.20156423
43CLK11.18589934
44FES1.17027360
45TAF11.14441534
46CCNB11.08326442
47CDC71.07864241
48AKT31.05020383
49BRD41.04839067
50PLK31.04380702
51CSNK1G11.03752776
52STK391.02456198
53CDK71.00947354
54MUSK0.99271012
55STK38L0.98258926
56CDK80.97117927
57MAPK130.96831461
58PNCK0.96759403
59CSNK1A1L0.96758605
60AURKA0.95814403
61CSNK1G20.95107062
62EIF2AK20.95034532
63CSNK1G30.90778015
64MAP3K110.89116428
65CHEK20.87460043
66DYRK20.86344812
67AURKB0.84426076
68GRK10.84235552
69OXSR10.83515787
70PINK10.82651786
71MAP2K70.81260283
72BLK0.77987254
73ADRBK20.75807828
74ATR0.75265626
75PRKCI0.75240660
76RPS6KB20.74478271
77PAK40.71850906
78NEK20.70865685
79DAPK30.69201553
80NLK0.67870020
81INSRR0.66004028
82TESK10.65913046
83LIMK10.65891485
84TGFBR10.63788152
85CDK190.62905158
86PASK0.61230663
87ACVR1B0.58738412
88CSNK2A10.57332559
89MAP3K80.56069070
90MST40.55776083
91PRKCE0.55299971
92BRAF0.55083956
93RPS6KA50.54100626
94LATS20.53433183
95BRSK10.52591249
96FGFR10.52355495
97PAK10.50382438
98CSNK2A20.50090628
99BRSK20.49151633
100PRPF4B0.48992427
101YES10.48940488
102STK40.48386535
103STK380.46220676
104PRKD20.45652573
105KDR0.45270246
106ATM0.45038883
107ERBB40.44474385
108PAK30.44015501
109TXK0.43524883
110CHEK10.41388420
111SGK20.41131397
112WNK40.39338140
113ABL20.38476920
114PIM10.36241217
115MELK0.35751788
116PRKCG0.35641682
117CSNK1A10.35224631
118FER0.34866718
119IKBKB0.34541557
120CDK20.34427151
121OBSCN0.33700520
122ALK0.33577056
123CSK0.31875497
124NEK60.31505255
125STK100.31446036
126PRKACB0.31132978
127RPS6KA40.30947492
128CSNK1D0.29971941
129CAMK2B0.29744882
130FGFR20.29525031
131TEC0.29248879
132RPS6KB10.28879702
133EPHA40.28579785
134PIK3CA0.28120505
135DYRK1B0.28023251
136MINK10.27759555
137CDK10.25607614
138NUAK10.21744572
139CAMK2G0.20347040
140CSNK1E0.20134877
141CAMK2D0.19863507
142CDK90.19562177
143MAPK40.19035285
144BMPR1B0.18579691
145PRKDC0.17698310
146LYN0.17319087
147ADRBK10.15912614
148CDK140.15705981
149TAOK20.14283716

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.63961457
2RNA polymerase_Homo sapiens_hsa030204.18491277
3DNA replication_Homo sapiens_hsa030303.94946616
4Proteasome_Homo sapiens_hsa030503.46778538
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.30961167
6Mismatch repair_Homo sapiens_hsa034303.30762347
7Spliceosome_Homo sapiens_hsa030403.22829014
8Homologous recombination_Homo sapiens_hsa034403.08503031
9Fanconi anemia pathway_Homo sapiens_hsa034602.68651585
10Pyrimidine metabolism_Homo sapiens_hsa002402.68383822
11One carbon pool by folate_Homo sapiens_hsa006702.67004155
12Nucleotide excision repair_Homo sapiens_hsa034202.48779798
13RNA transport_Homo sapiens_hsa030132.41622970
14Base excision repair_Homo sapiens_hsa034102.28847018
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.27968082
16Basal transcription factors_Homo sapiens_hsa030222.26195938
17Propanoate metabolism_Homo sapiens_hsa006402.24924671
18Cell cycle_Homo sapiens_hsa041102.02078991
19Protein export_Homo sapiens_hsa030601.91249620
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83322789
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82957260
22Selenocompound metabolism_Homo sapiens_hsa004501.77512128
23Oxidative phosphorylation_Homo sapiens_hsa001901.77030571
24Steroid biosynthesis_Homo sapiens_hsa001001.58204006
25Parkinsons disease_Homo sapiens_hsa050121.55357501
26Huntingtons disease_Homo sapiens_hsa050161.48396187
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47565334
28p53 signaling pathway_Homo sapiens_hsa041151.46965452
29Purine metabolism_Homo sapiens_hsa002301.46818341
30Sulfur relay system_Homo sapiens_hsa041221.45447794
31RNA degradation_Homo sapiens_hsa030181.40676605
32Butanoate metabolism_Homo sapiens_hsa006501.40008079
33Non-homologous end-joining_Homo sapiens_hsa034501.30660654
34mRNA surveillance pathway_Homo sapiens_hsa030151.29398020
35Epstein-Barr virus infection_Homo sapiens_hsa051691.23503768
36Folate biosynthesis_Homo sapiens_hsa007901.22127772
37Vitamin B6 metabolism_Homo sapiens_hsa007501.11288020
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02849758
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01811542
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92443634
41Cyanoamino acid metabolism_Homo sapiens_hsa004600.90940824
42Peroxisome_Homo sapiens_hsa041460.90932996
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90492326
44Alzheimers disease_Homo sapiens_hsa050100.90076534
45Olfactory transduction_Homo sapiens_hsa047400.90028758
46Phototransduction_Homo sapiens_hsa047440.85292583
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84210385
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81942461
49Pyruvate metabolism_Homo sapiens_hsa006200.81506291
50Tryptophan metabolism_Homo sapiens_hsa003800.78827850
51Sulfur metabolism_Homo sapiens_hsa009200.76035785
52Herpes simplex infection_Homo sapiens_hsa051680.74563613
53Systemic lupus erythematosus_Homo sapiens_hsa053220.74163400
54Taste transduction_Homo sapiens_hsa047420.73631115
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73145280
56Oocyte meiosis_Homo sapiens_hsa041140.70907851
57Circadian rhythm_Homo sapiens_hsa047100.69600435
58Fatty acid elongation_Homo sapiens_hsa000620.68502328
59Nitrogen metabolism_Homo sapiens_hsa009100.68128792
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.67282182
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67152552
62Glutathione metabolism_Homo sapiens_hsa004800.67145629
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66177218
64Arachidonic acid metabolism_Homo sapiens_hsa005900.64245694
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63341788
66Sphingolipid metabolism_Homo sapiens_hsa006000.60560719
67Lysine degradation_Homo sapiens_hsa003100.60467337
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57051926
69Fatty acid metabolism_Homo sapiens_hsa012120.56905992
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56596786
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55375092
72Thyroid cancer_Homo sapiens_hsa052160.55139668
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55087862
74Basal cell carcinoma_Homo sapiens_hsa052170.54879436
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53639715
76beta-Alanine metabolism_Homo sapiens_hsa004100.53372344
77Nicotine addiction_Homo sapiens_hsa050330.52536811
78Primary immunodeficiency_Homo sapiens_hsa053400.52071205
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52001753
80HTLV-I infection_Homo sapiens_hsa051660.51737942
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.50502938
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50182243
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.47514793
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47130651
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46986737
86Vitamin digestion and absorption_Homo sapiens_hsa049770.45777360
87Antigen processing and presentation_Homo sapiens_hsa046120.45588957
88Caffeine metabolism_Homo sapiens_hsa002320.45484224
89Viral carcinogenesis_Homo sapiens_hsa052030.42473979
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40694080
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39974556
92Other glycan degradation_Homo sapiens_hsa005110.39878099
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39537094
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38695655
95Fatty acid degradation_Homo sapiens_hsa000710.38429012
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37789494
97Measles_Homo sapiens_hsa051620.37586853
98Pentose phosphate pathway_Homo sapiens_hsa000300.36950116
99Metabolic pathways_Homo sapiens_hsa011000.36670285
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.36445516
101N-Glycan biosynthesis_Homo sapiens_hsa005100.36142955
102Wnt signaling pathway_Homo sapiens_hsa043100.36054905
103Hedgehog signaling pathway_Homo sapiens_hsa043400.34800911
104Melanoma_Homo sapiens_hsa052180.33919184
105Hippo signaling pathway_Homo sapiens_hsa043900.33801051
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.33154602
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33003845
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32628069
109Carbon metabolism_Homo sapiens_hsa012000.32523255
110Arginine and proline metabolism_Homo sapiens_hsa003300.32153978
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31929174
112Graft-versus-host disease_Homo sapiens_hsa053320.31862804
113Acute myeloid leukemia_Homo sapiens_hsa052210.30752348
114TGF-beta signaling pathway_Homo sapiens_hsa043500.30724659
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30255039
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29823321
117Bladder cancer_Homo sapiens_hsa052190.29627547
118GABAergic synapse_Homo sapiens_hsa047270.28794307
119Regulation of autophagy_Homo sapiens_hsa041400.28265257
120MicroRNAs in cancer_Homo sapiens_hsa052060.26400216
121ABC transporters_Homo sapiens_hsa020100.24476845
122Cardiac muscle contraction_Homo sapiens_hsa042600.22499849
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21755039
124Prostate cancer_Homo sapiens_hsa052150.21388585
125Shigellosis_Homo sapiens_hsa051310.19232097
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.18951729
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18940356
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.18880679
129Linoleic acid metabolism_Homo sapiens_hsa005910.18112297
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17698419
131Hematopoietic cell lineage_Homo sapiens_hsa046400.16999003
132Apoptosis_Homo sapiens_hsa042100.16620710
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.15805226
134Alcoholism_Homo sapiens_hsa050340.15677590
135Allograft rejection_Homo sapiens_hsa053300.15117444
136Pathways in cancer_Homo sapiens_hsa052000.14282617
137Ether lipid metabolism_Homo sapiens_hsa005650.12128465
138Tight junction_Homo sapiens_hsa045300.11966792
139Biosynthesis of amino acids_Homo sapiens_hsa012300.11736540
140Retinol metabolism_Homo sapiens_hsa008300.11250565
141Hepatitis B_Homo sapiens_hsa051610.11131997
142HIF-1 signaling pathway_Homo sapiens_hsa040660.11016448
143Asthma_Homo sapiens_hsa053100.09091991
144Autoimmune thyroid disease_Homo sapiens_hsa053200.08924194
145Legionellosis_Homo sapiens_hsa051340.06053647
146Small cell lung cancer_Homo sapiens_hsa052220.06018026

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »