WDR90

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)6.37662761
2cilium or flagellum-dependent cell motility (GO:0001539)6.35014710
3DNA unwinding involved in DNA replication (GO:0006268)6.33371881
4motile cilium assembly (GO:0044458)6.30792213
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.24797397
6cilium movement (GO:0003341)5.19761039
7protein localization to kinetochore (GO:0034501)5.14942164
8lung epithelium development (GO:0060428)4.93486049
9epithelial cilium movement (GO:0003351)4.51599317
10translesion synthesis (GO:0019985)4.44728356
11mitotic sister chromatid cohesion (GO:0007064)4.41797131
12mitotic chromosome condensation (GO:0007076)4.36102790
13establishment of apical/basal cell polarity (GO:0035089)4.35298751
14DNA strand elongation involved in DNA replication (GO:0006271)4.29819613
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.22827128
16protein localization to chromosome, centromeric region (GO:0071459)4.20423012
17pre-miRNA processing (GO:0031054)4.15838947
18sister chromatid segregation (GO:0000819)4.12969940
19DNA strand elongation (GO:0022616)4.10452221
20telomere maintenance via semi-conservative replication (GO:0032201)4.04899497
21establishment or maintenance of monopolar cell polarity (GO:0061339)4.04802178
22establishment of monopolar cell polarity (GO:0061162)4.04802178
23negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.03507724
24DNA replication initiation (GO:0006270)4.02073725
25positive regulation of protein kinase C signaling (GO:0090037)3.97830367
26nuclear pore complex assembly (GO:0051292)3.96872165
27DNA duplex unwinding (GO:0032508)3.94850113
28dosage compensation (GO:0007549)3.94578130
29DNA geometric change (GO:0032392)3.94081230
30positive regulation of CREB transcription factor activity (GO:0032793)3.93142791
31mitotic sister chromatid segregation (GO:0000070)3.87698525
32axoneme assembly (GO:0035082)3.87201041
33protein localization to chromosome (GO:0034502)3.84182964
34mitotic recombination (GO:0006312)3.83014622
35negative regulation of histone methylation (GO:0031061)3.81458548
36protein-DNA complex disassembly (GO:0032986)3.80784185
37nucleosome disassembly (GO:0006337)3.80784185
38nuclear pore organization (GO:0006999)3.75928926
39peptidyl-lysine dimethylation (GO:0018027)3.74983977
40left/right pattern formation (GO:0060972)3.74547048
41telomere maintenance via recombination (GO:0000722)3.72360027
42nephron tubule morphogenesis (GO:0072078)3.65956043
43nephron epithelium morphogenesis (GO:0072088)3.65956043
44semaphorin-plexin signaling pathway (GO:0071526)3.62923293
45positive regulation of histone deacetylation (GO:0031065)3.59818838
46negative regulation of RNA splicing (GO:0033119)3.56330088
47negative regulation of T cell differentiation in thymus (GO:0033085)3.53450446
48chromatin assembly (GO:0031497)3.53252282
49regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.51135669
50heterochromatin organization (GO:0070828)3.51012438
51negative regulation of mRNA processing (GO:0050686)3.49782564
52mitotic nuclear envelope disassembly (GO:0007077)3.48578239
53histone H2A acetylation (GO:0043968)3.47816193
54DNA replication-dependent nucleosome organization (GO:0034723)3.47375837
55DNA replication-dependent nucleosome assembly (GO:0006335)3.47375837
56pore complex assembly (GO:0046931)3.45672307
57collecting duct development (GO:0072044)3.42310297
58chromatin assembly or disassembly (GO:0006333)3.40731158
59regulation of sister chromatid cohesion (GO:0007063)3.36407009
60regulation of histone H3-K9 methylation (GO:0051570)3.35483289
61membrane disassembly (GO:0030397)3.33934341
62nuclear envelope disassembly (GO:0051081)3.33934341
63negative regulation of mRNA metabolic process (GO:1903312)3.33059418
64snRNA metabolic process (GO:0016073)3.32561384
65snRNA processing (GO:0016180)3.30495868
66DNA conformation change (GO:0071103)3.30114629
67regulation of RNA export from nucleus (GO:0046831)3.30018594
68mannose metabolic process (GO:0006013)3.28649623
69spliceosomal tri-snRNP complex assembly (GO:0000244)3.28263387
70nucleotide-excision repair, DNA gap filling (GO:0006297)3.25723375
71positive regulation of histone H3-K4 methylation (GO:0051571)3.23281304
72regulation of chromatin binding (GO:0035561)3.23074136
73folic acid-containing compound biosynthetic process (GO:0009396)3.21288528
74postreplication repair (GO:0006301)3.21199886
75regulation of telomere maintenance via telomerase (GO:0032210)3.19901460
76chromosome condensation (GO:0030261)3.17545968
77regulation of DNA endoreduplication (GO:0032875)3.17337433
78regulation of histone H3-K4 methylation (GO:0051569)3.16290338
79mRNA stabilization (GO:0048255)3.13165068
80RNA stabilization (GO:0043489)3.13165068
81ATP-dependent chromatin remodeling (GO:0043044)3.13019287
82phosphorelay signal transduction system (GO:0000160)3.12085781
83modulation by virus of host process (GO:0019054)3.12019611
84glucocorticoid receptor signaling pathway (GO:0042921)3.10430880
85DNA replication-independent nucleosome organization (GO:0034724)3.09923218
86DNA replication-independent nucleosome assembly (GO:0006336)3.09923218
87regulation of centriole replication (GO:0046599)3.09919831
88chromosome segregation (GO:0007059)3.09500331
89cilium organization (GO:0044782)3.08947839
90COPI coating of Golgi vesicle (GO:0048205)3.08300312
91Golgi transport vesicle coating (GO:0048200)3.08300312
92neural tube development (GO:0021915)3.07780241
93regulation of translational fidelity (GO:0006450)3.05367746
94telomere maintenance via telomere lengthening (GO:0010833)3.04289619
95cilium assembly (GO:0042384)3.02111845
96cornea development in camera-type eye (GO:0061303)3.01154842
97kinetochore organization (GO:0051383)3.00929757
98DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.00327226
99DNA packaging (GO:0006323)2.98502101
100histone H4-K16 acetylation (GO:0043984)2.95696684
101negative regulation of gene expression, epigenetic (GO:0045814)2.94310537
102regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.93358941
103regulation of hippo signaling (GO:0035330)2.92445472
104planar cell polarity pathway involved in neural tube closure (GO:0090179)2.91923438
105DNA replication checkpoint (GO:0000076)2.91779994
106meiotic chromosome segregation (GO:0045132)2.91469838
107chromatin remodeling at centromere (GO:0031055)2.89434182
108white fat cell differentiation (GO:0050872)2.89185598
109base-excision repair (GO:0006284)2.88903181
110CENP-A containing nucleosome assembly (GO:0034080)2.86078310
111vitamin transmembrane transport (GO:0035461)2.85852920
112nucleosome organization (GO:0034728)2.85618695
113regulation of DNA damage checkpoint (GO:2000001)2.82176763
114positive regulation of synapse maturation (GO:0090129)2.81662253
115negative regulation of translation, ncRNA-mediated (GO:0040033)2.80203876
116regulation of translation, ncRNA-mediated (GO:0045974)2.80203876
117negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.80203876
118regulation of fatty acid beta-oxidation (GO:0031998)2.79533334
119chromatin silencing (GO:0006342)2.79471968
120morphogenesis of an endothelium (GO:0003159)2.79248516
121endothelial tube morphogenesis (GO:0061154)2.79248516
122behavioral response to nicotine (GO:0035095)2.79192885
123snRNA transcription (GO:0009301)2.76638588
124DNA synthesis involved in DNA repair (GO:0000731)2.74223473
125spindle assembly involved in mitosis (GO:0090307)2.74210313
126telomere maintenance (GO:0000723)2.74177535
127histone H4-K8 acetylation (GO:0043982)2.73043707
128histone H4-K5 acetylation (GO:0043981)2.73043707
129positive regulation of RNA splicing (GO:0033120)2.72232038
130DNA topological change (GO:0006265)2.72136763
131regulation of nucleobase-containing compound transport (GO:0032239)2.71164814
132telomere organization (GO:0032200)2.71038563
133gene silencing (GO:0016458)2.69553907
134histone H2A monoubiquitination (GO:0035518)2.68813445
135regulation of nuclear cell cycle DNA replication (GO:0033262)2.68795188
136regulation of centrosome cycle (GO:0046605)2.68732015
137nuclear envelope organization (GO:0006998)2.68540342
138DNA damage response, signal transduction resulting in transcription (GO:0042772)2.68515666
139mRNA splice site selection (GO:0006376)2.67712245
140regulation of hydrogen peroxide metabolic process (GO:0010310)2.67141948
141regulation of synapse maturation (GO:0090128)2.66578021
142regulation of chromosome segregation (GO:0051983)2.66115133
143histone H3-K9 methylation (GO:0051567)2.65817953
144spinal cord development (GO:0021510)2.65413414
145ventricular system development (GO:0021591)2.64459773
146microtubule bundle formation (GO:0001578)2.63015201
147centriole assembly (GO:0098534)2.61552820
148positive regulation of fatty acid beta-oxidation (GO:0032000)2.60839670
149protein localization to cilium (GO:0061512)2.57339733
150positive regulation of smoothened signaling pathway (GO:0045880)2.57324786
151positive regulation of triglyceride biosynthetic process (GO:0010867)2.55889654
152sex determination (GO:0007530)2.55597128
153regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.55423777
154histone H3-K4 trimethylation (GO:0080182)2.54333929
155ear development (GO:0043583)2.53565943
156intraciliary transport (GO:0042073)2.52144389
157endothelial cell chemotaxis (GO:0035767)2.52061439
158negative regulation of cell size (GO:0045792)2.49770886
159mRNA cleavage (GO:0006379)2.49612723
160negative regulation of macroautophagy (GO:0016242)2.49503656
161misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.48999616
162microtubule depolymerization (GO:0007019)2.48461394
163negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.48455709
164positive regulation of protein deacetylation (GO:0090312)2.47911759
165renal tubule morphogenesis (GO:0061333)2.45086483
166positive regulation by host of viral transcription (GO:0043923)2.43825497
167DNA methylation (GO:0006306)2.41163650
168DNA alkylation (GO:0006305)2.41163650
169urinary tract smooth muscle contraction (GO:0014848)2.40945109
170activation of Rac GTPase activity (GO:0032863)2.40809041
171cell migration in hindbrain (GO:0021535)2.40514403
172folic acid metabolic process (GO:0046655)2.40263437
173histone lysine methylation (GO:0034968)2.39513030
174atrioventricular valve morphogenesis (GO:0003181)2.39326534
175regulation of histone deacetylation (GO:0031063)2.37173131
176convergent extension (GO:0060026)2.37073010
177establishment of planar polarity (GO:0001736)2.35103283
178establishment of tissue polarity (GO:0007164)2.35103283
179peptidyl-lysine methylation (GO:0018022)2.34395241
180mitotic G1 DNA damage checkpoint (GO:0031571)2.33482045
181embryonic body morphogenesis (GO:0010172)2.32660766
182response to misfolded protein (GO:0051788)2.32449848
183histone H3-K4 methylation (GO:0051568)2.31334323
184phosphatidylglycerol biosynthetic process (GO:0006655)2.29596306
185positive regulation of gene expression, epigenetic (GO:0045815)2.29444672
186mitotic G1/S transition checkpoint (GO:0044819)2.29351164
187cellular response to ATP (GO:0071318)2.28577189
188apoptotic process involved in morphogenesis (GO:0060561)2.25959198
189spinal cord motor neuron differentiation (GO:0021522)2.25155332
190left/right axis specification (GO:0070986)2.24160492
191regulation of cilium movement (GO:0003352)2.23519016
192positive regulation of fatty acid oxidation (GO:0046321)2.23442868
193regulation of cilium assembly (GO:1902017)2.21858441
194maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.21525833
195regulation of triglyceride biosynthetic process (GO:0010866)2.20587420

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.45688974
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.99899890
3MYC_22102868_ChIP-Seq_BL_Human3.66715939
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.61993479
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.46500595
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.35054439
7CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.32569156
8DROSHA_22980978_ChIP-Seq_HELA_Human3.03993907
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.90167449
10* E2F1_21310950_ChIP-Seq_MCF-7_Human2.88526099
11* P68_20966046_ChIP-Seq_HELA_Human2.71017437
12CIITA_25753668_ChIP-Seq_RAJI_Human2.49901856
13* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.39555660
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.39304114
15SMC4_20622854_ChIP-Seq_HELA_Human2.36794599
16ERG_21242973_ChIP-ChIP_JURKAT_Human2.30037351
17AR_21909140_ChIP-Seq_LNCAP_Human2.22872704
18CTCF_27219007_Chip-Seq_Bcells_Human2.18864616
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.18369685
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.15238133
21* VDR_21846776_ChIP-Seq_THP-1_Human2.14735665
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.13293723
23* RACK7_27058665_Chip-Seq_MCF-7_Human2.07309671
24CREB1_26743006_Chip-Seq_LNCaP_Human2.05391072
25E2F7_22180533_ChIP-Seq_HELA_Human11.3629720
26PHF8_20622854_ChIP-Seq_HELA_Human1.95018514
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93991328
28RUNX1_27514584_Chip-Seq_MCF-7_Human1.91615344
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.91100812
30E2F1_20622854_ChIP-Seq_HELA_Human1.87732612
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86190217
32TCF7_22412390_ChIP-Seq_EML_Mouse1.85174345
33SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.82857647
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.79613058
35* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.77528709
36* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.74090346
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.72516955
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.70096268
39TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.69223428
40BCL6_27268052_Chip-Seq_Bcells_Human1.66966480
41SA1_27219007_Chip-Seq_ERYTHROID_Human1.64687650
42* BCOR_27268052_Chip-Seq_Bcells_Human1.64370738
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.63642099
44* TP63_22573176_ChIP-Seq_HFKS_Human1.63122931
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62832605
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.62758264
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.59778019
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.58879175
49RARB_24833708_ChIP-Seq_LIVER_Mouse1.58703219
50XRN2_22483619_ChIP-Seq_HELA_Human1.58432879
51HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.57966628
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.57609325
53CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.56721963
54* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.55270029
55* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53994582
56KDM2B_26808549_Chip-Seq_DND41_Human1.52998325
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.52910217
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49572922
59ESR1_15608294_ChIP-ChIP_MCF-7_Human1.47908231
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45543403
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43930853
62* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.43799608
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43610512
64* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43583944
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.42448173
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42408765
67DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.41348977
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.39762227
69OCT4_19829295_ChIP-Seq_ESCs_Human1.39141915
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39083839
71* ERA_21632823_ChIP-Seq_H3396_Human1.38016317
72EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.37261765
73UTX_26944678_Chip-Seq_JUKART_Human1.36474569
74MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35071236
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33761317
76SCL_19346495_ChIP-Seq_HPC-7_Human1.33626933
77* FOXP1_21924763_ChIP-Seq_HESCs_Human1.33177432
78KDM5A_27292631_Chip-Seq_BREAST_Human1.32786301
79RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.32696105
80RARA_24833708_ChIP-Seq_LIVER_Mouse1.32411385
81* CTCF_20526341_ChIP-Seq_ESCs_Human1.32302013
82* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32198777
83JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31886578
84SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31546059
85* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31120579
86ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31043483
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30220378
88PKCTHETA_26484144_Chip-Seq_BREAST_Human1.30088457
89* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.29064636
90ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28278260
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28073354
92ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23809641
93DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23714370
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23648400
95ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23369681
96RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22667860
97TP53_23651856_ChIP-Seq_MEFs_Mouse1.22175898
98SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20926158
99KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20429651
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20273647
101* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19327719
102MAF_26560356_Chip-Seq_TH1_Human1.18152796
103FOXP3_21729870_ChIP-Seq_TREG_Human1.17933279
104SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17155413
105* SA1_27219007_Chip-Seq_Bcells_Human1.17088576
106YY1_22570637_ChIP-Seq_MALME-3M_Human1.16266355
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16247553
108MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15693421
109E2F1_17053090_ChIP-ChIP_MCF-7_Human1.14946906
110* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14866577
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14408729
112MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14241526
113RNF2_27304074_Chip-Seq_ESCs_Mouse1.14076230
114TDRD3_21172665_ChIP-Seq_MCF-7_Human1.12341476
115* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12184805
116THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12161527
117TTF2_22483619_ChIP-Seq_HELA_Human1.11948446
118EZH2_22144423_ChIP-Seq_EOC_Human1.11660291
119SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10836557
120P300_27268052_Chip-Seq_Bcells_Human1.10579651
121ESR1_20079471_ChIP-ChIP_T-47D_Human1.09912056
122KLF5_25053715_ChIP-Seq_YYC3_Human1.09481069
123PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09338947
124MYC_27129775_Chip-Seq_CORNEA_Mouse1.08911558
125NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08636732
126KDM2B_26808549_Chip-Seq_JURKAT_Human1.07245050
127OCT4_20526341_ChIP-Seq_ESCs_Human1.06893295
128TP53_20018659_ChIP-ChIP_R1E_Mouse1.06150698
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05711184
130PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04892061
131* GABP_19822575_ChIP-Seq_HepG2_Human1.04549675
132TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02511580
133P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.02134019
134* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01929265
135ELK3_25401928_ChIP-Seq_HUVEC_Human1.01718786
136HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00886095
137ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00764577
138KDM2B_26808549_Chip-Seq_K562_Human1.00205404
139* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00110187
140FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99735890
141VDR_24763502_ChIP-Seq_THP-1_Human0.99568261
142STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99164165
143NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98856716
144CHD1_26751641_Chip-Seq_LNCaP_Human0.98598607
145CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97635623
146RAC3_21632823_ChIP-Seq_H3396_Human0.97228347
147RXRA_24833708_ChIP-Seq_LIVER_Mouse0.96580486
148ZNF274_21170338_ChIP-Seq_K562_Hela0.96495665
149* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95908959
150SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95011335
151NCOR1_26117541_ChIP-Seq_K562_Human0.93553252
152KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91518545
153E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90529484
154MYB_26560356_Chip-Seq_TH1_Human0.90434798
155LXR_22292898_ChIP-Seq_THP-1_Human0.88790791
156TP53_22127205_ChIP-Seq_IMR90_Human0.87816044
157STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87109124
158TFEB_21752829_ChIP-Seq_HELA_Human0.86273821
159* MAF_26560356_Chip-Seq_TH2_Human0.85432624
160CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.84663783
161ZNF263_19887448_ChIP-Seq_K562_Human0.84248768
162NANOG_21062744_ChIP-ChIP_HESCs_Human0.83696180
163P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83685398
164VDR_23849224_ChIP-Seq_CD4+_Human0.83375316
165MYB_26560356_Chip-Seq_TH2_Human0.82499344
166KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82290511
167KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81955979
168ELF1_20517297_ChIP-Seq_JURKAT_Human0.79913412
169ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78940819
170PADI4_21655091_ChIP-ChIP_MCF-7_Human0.78846411
171WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.78828772

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.13639280
2MP0010094_abnormal_chromosome_stability3.59024835
3MP0002249_abnormal_larynx_morphology3.52660869
4MP0000566_synostosis3.46928361
5MP0003111_abnormal_nucleus_morphology3.42414501
6MP0003693_abnormal_embryo_hatching3.38176631
7MP0003283_abnormal_digestive_organ3.07039463
8MP0008057_abnormal_DNA_replication3.04336544
9MP0010352_gastrointestinal_tract_polyps2.76096570
10MP0005076_abnormal_cell_differentiation2.74646764
11MP0003077_abnormal_cell_cycle2.63288283
12MP0003123_paternal_imprinting2.58093161
13MP0003121_genomic_imprinting2.51477178
14MP0004957_abnormal_blastocyst_morpholog2.44333192
15MP0000569_abnormal_digit_pigmentation2.44127324
16MP0004133_heterotaxia2.36312064
17MP0008875_abnormal_xenobiotic_pharmacok2.34037244
18MP0005171_absent_coat_pigmentation2.31420268
19MP0008058_abnormal_DNA_repair2.08045443
20MP0004043_abnormal_pH_regulation2.00258322
21MP0000383_abnormal_hair_follicle1.96548357
22MP0008007_abnormal_cellular_replicative1.96159894
23MP0004808_abnormal_hematopoietic_stem1.93676809
24MP0002877_abnormal_melanocyte_morpholog1.92866398
25MP0003787_abnormal_imprinting1.92728238
26MP0008877_abnormal_DNA_methylation1.92327931
27MP0002396_abnormal_hematopoietic_system1.87260668
28MP0010307_abnormal_tumor_latency1.86693075
29MP0001730_embryonic_growth_arrest1.85285263
30MP0000350_abnormal_cell_proliferation1.83647988
31MP0005377_hearing/vestibular/ear_phenot1.82534013
32MP0003878_abnormal_ear_physiology1.82534013
33MP0004381_abnormal_hair_follicle1.79817033
34MP0002653_abnormal_ependyma_morphology1.70716421
35MP0001348_abnormal_lacrimal_gland1.70057028
36MP0003122_maternal_imprinting1.62103740
37MP0008932_abnormal_embryonic_tissue1.62046915
38MP0008789_abnormal_olfactory_epithelium1.60827018
39MP0001188_hyperpigmentation1.59850906
40MP0004197_abnormal_fetal_growth/weight/1.57916665
41MP0002085_abnormal_embryonic_tissue1.57394977
42MP0000537_abnormal_urethra_morphology1.56817084
43MP0001485_abnormal_pinna_reflex1.55674078
44MP0005499_abnormal_olfactory_system1.50009515
45MP0005394_taste/olfaction_phenotype1.50009515
46MP0009672_abnormal_birth_weight1.48233990
47MP0002084_abnormal_developmental_patter1.47800766
48MP0009278_abnormal_bone_marrow1.46664998
49MP0001502_abnormal_circadian_rhythm1.45089278
50MP0005409_darkened_coat_color1.42920782
51MP0005380_embryogenesis_phenotype1.41916531
52MP0001672_abnormal_embryogenesis/_devel1.41916531
53MP0008995_early_reproductive_senescence1.40160942
54MP0009703_decreased_birth_body1.36107307
55MP0002080_prenatal_lethality1.36092134
56MP0000678_abnormal_parathyroid_gland1.35806850
57MP0003119_abnormal_digestive_system1.35494557
58MP0002234_abnormal_pharynx_morphology1.32656912
59MP0001697_abnormal_embryo_size1.32389714
60MP0000703_abnormal_thymus_morphology1.32099114
61MP0010030_abnormal_orbit_morphology1.31124140
62MP0005551_abnormal_eye_electrophysiolog1.29840232
63MP0008961_abnormal_basal_metabolism1.29789565
64MP0001849_ear_inflammation1.29331771
65MP0003115_abnormal_respiratory_system1.28347710
66MP0000026_abnormal_inner_ear1.27647840
67MP0002098_abnormal_vibrissa_morphology1.27406223
68MP0002086_abnormal_extraembryonic_tissu1.27167391
69MP0003984_embryonic_growth_retardation1.26417103
70MP0002088_abnormal_embryonic_growth/wei1.25328002
71MP0000428_abnormal_craniofacial_morphol1.24906818
72MP0003942_abnormal_urinary_system1.22326639
73MP0003935_abnormal_craniofacial_develop1.14489560
74MP0005220_abnormal_exocrine_pancreas1.14160662
75MP0000313_abnormal_cell_death1.11656363
76MP0002735_abnormal_chemical_nociception1.11644941
77MP0001346_abnormal_lacrimal_gland1.11618273
78MP0002938_white_spotting1.11394826
79MP0001293_anophthalmia1.11311972
80MP0000427_abnormal_hair_cycle1.10899363
81MP0000049_abnormal_middle_ear1.10826871
82MP0005174_abnormal_tail_pigmentation1.10806251
83MP0003705_abnormal_hypodermis_morpholog1.10703350
84MP0010678_abnormal_skin_adnexa1.10646452
85MP0002822_catalepsy1.10354659
86MP0001944_abnormal_pancreas_morphology1.09905000
87MP0006054_spinal_hemorrhage1.09567731
88MP0003861_abnormal_nervous_system1.09566781
89MP0003890_abnormal_embryonic-extraembry1.08930182
90MP0005645_abnormal_hypothalamus_physiol1.08572690
91MP0001765_abnormal_ion_homeostasis1.08168364
92MP0001968_abnormal_touch/_nociception1.07804808
93MP0001915_intracranial_hemorrhage1.07212597
94MP0009384_cardiac_valve_regurgitation1.05844064
95MP0005187_abnormal_penis_morphology1.05102784
96MP0003763_abnormal_thymus_physiology1.04969914
97MP0000003_abnormal_adipose_tissue1.04939442
98MP0000015_abnormal_ear_pigmentation1.04696345
99MP0000013_abnormal_adipose_tissue1.01866087
100MP0000490_abnormal_crypts_of1.01583451
101MP0000579_abnormal_nail_morphology0.99275855
102MP0005083_abnormal_biliary_tract0.98856314
103MP0002019_abnormal_tumor_incidence0.98700527
104MP0002160_abnormal_reproductive_system0.97079560
105MP0004233_abnormal_muscle_weight0.97069080
106MP0005670_abnormal_white_adipose0.96990905
107MP0003300_gastrointestinal_ulcer0.96906937
108MP0003045_fibrosis0.96556004
109MP0001270_distended_abdomen0.96484074
110MP0005503_abnormal_tendon_morphology0.95516007
111MP0001664_abnormal_digestion0.95371012
112MP0000631_abnormal_neuroendocrine_gland0.94952362
113MP0002210_abnormal_sex_determination0.93454522
114MP0002697_abnormal_eye_size0.93035876
115MP0002876_abnormal_thyroid_physiology0.91006360
116MP0002282_abnormal_trachea_morphology0.90832225
117MP0002557_abnormal_social/conspecific_i0.90498724
118MP0009780_abnormal_chondrocyte_physiolo0.90089581
119MP0002116_abnormal_craniofacial_bone0.90087712
120MP0002092_abnormal_eye_morphology0.90075044
121MP0002111_abnormal_tail_morphology0.87439660
122MP0008872_abnormal_physiological_respon0.86441832
123MP0001986_abnormal_taste_sensitivity0.85147845
124MP0002089_abnormal_postnatal_growth/wei0.84773438
125MP0001873_stomach_inflammation0.84424214
126MP0003698_abnormal_male_reproductive0.84291867
127MP0000371_diluted_coat_color0.84006490
128MP0004742_abnormal_vestibular_system0.83709699
129MP0003943_abnormal_hepatobiliary_system0.82698456
130MP0005397_hematopoietic_system_phenotyp0.82447850
131MP0001545_abnormal_hematopoietic_system0.82447850
132MP0003172_abnormal_lysosome_physiology0.81597895
133MP0003938_abnormal_ear_development0.81592898
134MP0002752_abnormal_somatic_nervous0.80277956
135MP0003567_abnormal_fetal_cardiomyocyte0.80213232
136MP0002398_abnormal_bone_marrow0.80148515
137MP0002075_abnormal_coat/hair_pigmentati0.79798846
138MP0000470_abnormal_stomach_morphology0.79643777
139MP0001145_abnormal_male_reproductive0.78800481
140MP0002928_abnormal_bile_duct0.78644629
141MP0002932_abnormal_joint_morphology0.78443560
142MP0002925_abnormal_cardiovascular_devel0.78111162
143MP0000538_abnormal_urinary_bladder0.77824944
144MP0000681_abnormal_thyroid_gland0.77824268
145MP0003755_abnormal_palate_morphology0.77092878
146MP0002095_abnormal_skin_pigmentation0.76878876
147MP0000613_abnormal_salivary_gland0.74586067
148MP0003566_abnormal_cell_adhesion0.74080377
149MP0000432_abnormal_head_morphology0.73147902
150MP0003937_abnormal_limbs/digits/tail_de0.72997827
151MP0002572_abnormal_emotion/affect_behav0.71867879
152MP0003786_premature_aging0.71494836
153MP0002970_abnormal_white_adipose0.71137220
154MP0005195_abnormal_posterior_eye0.70794600
155MP0002081_perinatal_lethality0.70554408
156MP0000467_abnormal_esophagus_morphology0.70350976
157MP0002233_abnormal_nose_morphology0.70272148
158MP0004858_abnormal_nervous_system0.69933835
159MP0002114_abnormal_axial_skeleton0.69629456
160MP0002184_abnormal_innervation0.69391753
161MP0005423_abnormal_somatic_nervous0.66046622
162MP0001929_abnormal_gametogenesis0.65363422

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)4.62549089
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.62549089
3Abnormal respiratory motile cilium morphology (HP:0005938)4.62013798
4Abnormal respiratory epithelium morphology (HP:0012253)4.62013798
5Abnormal ciliary motility (HP:0012262)4.34000582
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.27720831
7Hyperacusis (HP:0010780)4.11232755
8Abnormal respiratory motile cilium physiology (HP:0012261)4.08837194
9Cystic liver disease (HP:0006706)3.58829099
10Increased nuchal translucency (HP:0010880)3.54334879
11Renal duplication (HP:0000075)3.51836122
12Volvulus (HP:0002580)3.41453207
13Rhinitis (HP:0012384)3.40588484
14Renovascular hypertension (HP:0100817)3.39797170
15Elfin facies (HP:0004428)3.38533930
16Nephronophthisis (HP:0000090)3.23247215
17Insomnia (HP:0100785)3.22488289
18Genetic anticipation (HP:0003743)3.16954250
19Molar tooth sign on MRI (HP:0002419)3.14055412
20Abnormality of midbrain morphology (HP:0002418)3.14055412
21Abnormality of the fingertips (HP:0001211)2.97895149
22Tubular atrophy (HP:0000092)2.91958735
23Ependymoma (HP:0002888)2.90917517
24Overriding aorta (HP:0002623)2.85880345
25Broad face (HP:0000283)2.81407230
26Chronic hepatic failure (HP:0100626)2.75297470
27Rib fusion (HP:0000902)2.71519505
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.70211136
29Short 4th metacarpal (HP:0010044)2.70211136
30Abnormal number of incisors (HP:0011064)2.68205780
31Bowel diverticulosis (HP:0005222)2.68152306
32Chronic bronchitis (HP:0004469)2.65231101
33True hermaphroditism (HP:0010459)2.64667967
3411 pairs of ribs (HP:0000878)2.63262104
35Bronchiectasis (HP:0002110)2.62693054
36Bronchomalacia (HP:0002780)2.59627317
37Bell-shaped thorax (HP:0001591)2.56912106
38Abnormality of the renal medulla (HP:0100957)2.55924737
39Congenital stationary night blindness (HP:0007642)2.55682591
40Occipital encephalocele (HP:0002085)2.55223469
41Pancreatic fibrosis (HP:0100732)2.52611632
42Pointed chin (HP:0000307)2.51176356
43Pancreatic cysts (HP:0001737)2.50335112
44Missing ribs (HP:0000921)2.48841905
45High pitched voice (HP:0001620)2.48632590
46Colon cancer (HP:0003003)2.46964210
47Abnormality of the carotid arteries (HP:0005344)2.46895820
48Abnormality of the diencephalon (HP:0010662)2.43924083
49Medulloblastoma (HP:0002885)2.43370065
50Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.42477740
51Obstructive sleep apnea (HP:0002870)2.42044812
52Selective tooth agenesis (HP:0001592)2.41663839
53Nasal polyposis (HP:0100582)2.37993294
54Flat cornea (HP:0007720)2.35838405
55Obsessive-compulsive behavior (HP:0000722)2.35437569
56Skull defect (HP:0001362)2.34270131
57Duplicated collecting system (HP:0000081)2.34046123
58Chromosomal breakage induced by crosslinking agents (HP:0003221)2.31381067
59Chromsome breakage (HP:0040012)2.30687463
60Astrocytoma (HP:0009592)2.26599744
61Abnormality of the astrocytes (HP:0100707)2.26599744
62Megalocornea (HP:0000485)2.26073864
63Cerebral aneurysm (HP:0004944)2.21023261
64Long eyelashes (HP:0000527)2.20102421
65Ulnar bowing (HP:0003031)2.19851562
66Skin tags (HP:0010609)2.16993641
67High anterior hairline (HP:0009890)2.16936159
68Truncal obesity (HP:0001956)2.16716384
69Abnormality of the renal collecting system (HP:0004742)2.16211419
70Prominent nose (HP:0000448)2.15500286
71Hypoplasia of the capital femoral epiphysis (HP:0003090)2.15073198
72Ectopic kidney (HP:0000086)2.12809423
73Aplasia/Hypoplasia of the uvula (HP:0010293)2.11419904
74Hypoplastic ischia (HP:0003175)2.10285129
75Preauricular skin tag (HP:0000384)2.10105246
76Stridor (HP:0010307)2.09088913
77Atelectasis (HP:0100750)2.08901468
78Sclerocornea (HP:0000647)2.08683779
79Cerebellar dysplasia (HP:0007033)2.07620800
80Protruding tongue (HP:0010808)2.07047766
81Congenital hepatic fibrosis (HP:0002612)2.06070523
82Abnormality of chromosome stability (HP:0003220)2.04166905
83Proximal placement of thumb (HP:0009623)2.03595975
84Clumsiness (HP:0002312)2.03063045
85Vertebral arch anomaly (HP:0008438)2.01040760
86Deviation of the thumb (HP:0009603)2.00557215
87Impaired smooth pursuit (HP:0007772)1.99292025
88Self-mutilation (HP:0000742)1.99242104
89Optic nerve coloboma (HP:0000588)1.94848873
90J-shaped sella turcica (HP:0002680)1.94020863
91Glioma (HP:0009733)1.93671376
92Heterotopia (HP:0002282)1.91473653
93Absent epiphyses (HP:0010577)1.91391398
94Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.91391398
95Trigonocephaly (HP:0000243)1.91034143
96Pseudobulbar signs (HP:0002200)1.89042155
97Sandal gap (HP:0001852)1.87455051
98Birth length less than 3rd percentile (HP:0003561)1.87382226
99Large for gestational age (HP:0001520)1.86515056
100Abnormality of endocrine pancreas physiology (HP:0012093)1.84923358
101Abnormality of the pancreatic islet cells (HP:0006476)1.84923358
102Hand muscle atrophy (HP:0009130)1.84198754
103Broad thumb (HP:0011304)1.83551969
104Bladder diverticulum (HP:0000015)1.83475641
105Abnormality of the 4th metacarpal (HP:0010012)1.83363875
106Abnormality of oral frenula (HP:0000190)1.83312388
107Abnormality of the ileum (HP:0001549)1.82679100
108Ankyloglossia (HP:0010296)1.82565699
109Broad phalanges of the hand (HP:0009768)1.81705216
110Cafe-au-lait spot (HP:0000957)1.81294379
111Meckel diverticulum (HP:0002245)1.81183239
112Broad palm (HP:0001169)1.81136450
113Retinal dysplasia (HP:0007973)1.80932593
114Postaxial foot polydactyly (HP:0001830)1.80826836
115Deep philtrum (HP:0002002)1.80581893
116Patellar aplasia (HP:0006443)1.79966662
117Decreased circulating renin level (HP:0003351)1.78618524
118Shallow orbits (HP:0000586)1.78516311
119Abnormality of the nasal mucosa (HP:0000433)1.78368056
120Atresia of the external auditory canal (HP:0000413)1.78229165
121Gastrointestinal carcinoma (HP:0002672)1.78153195
122Malignant gastrointestinal tract tumors (HP:0006749)1.78153195
123Stage 5 chronic kidney disease (HP:0003774)1.77777104
124Urethral obstruction (HP:0000796)1.77043567
125Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76701604
126Aplasia/Hypoplasia of the sternum (HP:0006714)1.76607662
127Polycystic kidney dysplasia (HP:0000113)1.75652838
128Pancreatic islet-cell hyperplasia (HP:0004510)1.75625298
129Abnormal drinking behavior (HP:0030082)1.75112040
130Polydipsia (HP:0001959)1.75112040
131Smooth philtrum (HP:0000319)1.75079343
132Sacral dimple (HP:0000960)1.74769948
133Slender long bone (HP:0003100)1.74658343
134Diastasis recti (HP:0001540)1.74638646
135Testicular atrophy (HP:0000029)1.74401915
136Hypoplasia of the pons (HP:0012110)1.74003158
137Macroorchidism (HP:0000053)1.73572539
138Abnormality of DNA repair (HP:0003254)1.73137186
139Myelodysplasia (HP:0002863)1.72897054
140Male infertility (HP:0003251)1.71802792
141Preaxial hand polydactyly (HP:0001177)1.71745725
142Short thumb (HP:0009778)1.71738075
143Type II lissencephaly (HP:0007260)1.70982173
144Abnormality of the ischium (HP:0003174)1.70856607
145Subacute progressive viral hepatitis (HP:0006572)1.70553859
146Tubulointerstitial nephritis (HP:0001970)1.70508803
147Broad finger (HP:0001500)1.70417985
148Small intestinal stenosis (HP:0012848)1.69799518
149Duodenal stenosis (HP:0100867)1.69799518
150Abnormality of the aortic arch (HP:0012303)1.69762138
151Abnormality of abdominal situs (HP:0011620)1.69677042
152Abdominal situs inversus (HP:0003363)1.69677042
153Cutis marmorata (HP:0000965)1.69622117
154Acute lymphatic leukemia (HP:0006721)1.69592204
155Spina bifida occulta (HP:0003298)1.69312102
156Absent frontal sinuses (HP:0002688)1.69153756
157Infertility (HP:0000789)1.68841761
158Highly arched eyebrow (HP:0002553)1.68739724
159Broad distal phalanx of finger (HP:0009836)1.68694800
160Neoplasm of the oral cavity (HP:0100649)1.68548006
161Absent radius (HP:0003974)1.67906442
162Breast hypoplasia (HP:0003187)1.67375741
163Aplasia involving forearm bones (HP:0009822)1.67219556
164Absent forearm bone (HP:0003953)1.67219556
165Abnormality of cochlea (HP:0000375)1.66363960
166Abnormality of the femoral head (HP:0003368)1.65549265
167Morphological abnormality of the inner ear (HP:0011390)1.62988111
168Basal cell carcinoma (HP:0002671)1.62821774
169Aplasia/Hypoplasia of the patella (HP:0006498)1.61898361
170Thick eyebrow (HP:0000574)1.61075407
171Tracheomalacia (HP:0002779)1.60745434
172Abnormality of the calcaneus (HP:0008364)1.60658423
173Absent thumb (HP:0009777)1.59838781
174Thin bony cortex (HP:0002753)1.59640912
175Intestinal fistula (HP:0100819)1.59561945
176Bowing of the arm (HP:0006488)1.59124342
177Bowed forearm bones (HP:0003956)1.59124342
178Spinal muscular atrophy (HP:0007269)1.59023536
179Overlapping toe (HP:0001845)1.58774333
180Tented upper lip vermilion (HP:0010804)1.58216905
181Neoplasm of striated muscle (HP:0009728)1.57706248
182Anencephaly (HP:0002323)1.56835095
183Rhabdomyosarcoma (HP:0002859)1.56497648
184Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.55599829
185Abnormality of chromosome segregation (HP:0002916)1.55521414

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK4.63207912
2CDC74.06042491
3EEF2K3.58377642
4RIPK13.51819256
5MST1R3.40704774
6INSRR3.03813368
7EPHA23.00404740
8MAP3K102.93577340
9NEK22.79606136
10PKN22.75167172
11CDK122.64049967
12FRK2.63357323
13TRIB32.59877663
14WNK42.45629373
15SMG12.42535652
16WEE12.18072952
17ICK1.88326258
18BRD41.85068955
19MET1.83647875
20NME11.79717415
21SCYL21.74873512
22MAPKAPK31.72427314
23SIK21.70695868
24MAP2K61.64265367
25PTK61.61506649
26ATR1.56172326
27SIK11.56150670
28BRSK11.43822464
29ZAK1.40959098
30PDGFRA1.36163996
31BRSK21.35312143
32PRKD31.34499021
33MAP3K71.33790423
34TTK1.33252037
35PLK11.32947285
36BUB11.32237746
37CHEK11.31609583
38CDK41.30997697
39TNK21.22326103
40CCNB11.17965615
41RPS6KB21.17424922
42FGFR21.15143702
43CDK81.14619418
44HIPK21.13825405
45MTOR1.13812902
46MAP4K11.11998769
47AURKB1.11307535
48IRAK31.10338093
49MARK21.10045899
50PLK31.09207833
51GRK11.04920052
52CDK71.03493577
53CAMKK11.03320248
54BMPR1B1.02138794
55FLT31.01840961
56PNCK1.00113772
57TAOK11.00014048
58CAMK1D0.99703580
59TSSK60.99046190
60CHEK20.97264099
61ALK0.96945571
62NEK10.96118434
63MKNK10.95229414
64RPS6KA60.94882020
65MUSK0.94443649
66SRPK10.94273968
67MAP2K20.92719732
68PAK40.91557468
69PRKD20.87560543
70CDK20.86973209
71CAMK1G0.85603533
72MKNK20.84301851
73CHUK0.84237937
74STK100.84097172
75UHMK10.83993056
76STK390.81961828
77PRKAA10.81536127
78CDK60.81027153
79MAP2K30.80160112
80PRKCI0.79839432
81ATM0.78731035
82MAP3K80.78454309
83KSR10.77901910
84CDC42BPA0.77691915
85VRK10.75375316
86CDK10.72262915
87DYRK30.70378956
88TTN0.67463176
89AURKA0.65965466
90PRKAA20.63635284
91DYRK1B0.62920122
92ADRBK20.61885401
93PLK40.61757642
94TYRO30.61445118
95RPS6KA40.61285376
96MAPK110.61247847
97RPS6KA20.61011684
98STK40.59552848
99LMTK20.58732215
100MAPKAPK50.56211944
101MAPK140.55588639
102PIM10.55106011
103GRK60.54307126
104MELK0.54270562
105BTK0.53638261
106FGFR40.53096849
107RAF10.52906930
108CLK10.51965461
109PRKDC0.51939330
110TAOK30.51030080
111DAPK10.50476682
112MAPK80.50071836
113TGFBR10.49748989
114MAP3K60.49399884
115AKT20.47815706
116DMPK0.45285925
117ARAF0.45170853
118NTRK30.44778991
119ERBB30.44527913
120FGFR10.44129752
121PRKCH0.43071160
122IRAK10.42030405
123SIK30.41963733
124DAPK20.41712023
125AKT10.41456214
126MAPK90.40949095
127GSK3B0.40925318
128NTRK20.40667475
129TLK10.40652969
130PTK20.40045611
131CSNK1D0.39695413
132RPS6KL10.38970946
133RPS6KC10.38970946
134BMX0.38696707
135MAPK150.38409880
136RPS6KA10.38406660
137ERBB20.38119579
138PAK20.37600337
139MAPK10.35609233
140PTK2B0.34091952
141MAPK130.32012712
142IRAK20.31853642
143CDK30.30624977
144TRPM70.30342949
145CDK90.30202846
146ERN10.30109527
147MAPK30.29212314
148PKN10.28369382
149ACVR1B0.27504758
150STK110.27126707
151RPS6KA50.26899681
152ADRBK10.25616646

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.21117384
2Mismatch repair_Homo sapiens_hsa034303.51812850
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.29825250
4Cell cycle_Homo sapiens_hsa041102.68960978
5Base excision repair_Homo sapiens_hsa034102.65612389
6ABC transporters_Homo sapiens_hsa020102.45799129
7Spliceosome_Homo sapiens_hsa030402.45123157
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.29055436
9Sulfur relay system_Homo sapiens_hsa041222.26178257
10mRNA surveillance pathway_Homo sapiens_hsa030152.02391840
11Homologous recombination_Homo sapiens_hsa034402.00995492
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.99959037
13Linoleic acid metabolism_Homo sapiens_hsa005911.99296360
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.95574472
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88670321
16RNA transport_Homo sapiens_hsa030131.88631142
17One carbon pool by folate_Homo sapiens_hsa006701.84581895
18Fanconi anemia pathway_Homo sapiens_hsa034601.77573479
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75680036
20Chronic myeloid leukemia_Homo sapiens_hsa052201.69014420
21Nucleotide excision repair_Homo sapiens_hsa034201.68249873
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.63266071
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.60180510
24Taste transduction_Homo sapiens_hsa047421.58773213
25Lysine degradation_Homo sapiens_hsa003101.58382738
26Other glycan degradation_Homo sapiens_hsa005111.41730887
27Alcoholism_Homo sapiens_hsa050341.38115132
28Ether lipid metabolism_Homo sapiens_hsa005651.38075477
29Systemic lupus erythematosus_Homo sapiens_hsa053221.37444292
30Phototransduction_Homo sapiens_hsa047441.36810925
31RNA degradation_Homo sapiens_hsa030181.36309797
32MicroRNAs in cancer_Homo sapiens_hsa052061.35246131
33Nitrogen metabolism_Homo sapiens_hsa009101.35053662
34HTLV-I infection_Homo sapiens_hsa051661.32710409
35Histidine metabolism_Homo sapiens_hsa003401.31043269
36Colorectal cancer_Homo sapiens_hsa052101.29878822
37Notch signaling pathway_Homo sapiens_hsa043301.29212178
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.28210597
39Basal cell carcinoma_Homo sapiens_hsa052171.27204840
40Oocyte meiosis_Homo sapiens_hsa041141.26939436
41Nicotine addiction_Homo sapiens_hsa050331.24838150
42Endometrial cancer_Homo sapiens_hsa052131.24234771
43Ovarian steroidogenesis_Homo sapiens_hsa049131.23578865
44Viral carcinogenesis_Homo sapiens_hsa052031.22476517
45Non-small cell lung cancer_Homo sapiens_hsa052231.22362649
46Glycerophospholipid metabolism_Homo sapiens_hsa005641.22048317
47Small cell lung cancer_Homo sapiens_hsa052221.17697278
48mTOR signaling pathway_Homo sapiens_hsa041501.17253646
49Type II diabetes mellitus_Homo sapiens_hsa049301.14558592
50Non-homologous end-joining_Homo sapiens_hsa034501.13922260
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12573421
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.09378156
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09237186
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06946885
55Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05172881
56p53 signaling pathway_Homo sapiens_hsa041151.04271259
57Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03174121
58Neurotrophin signaling pathway_Homo sapiens_hsa047221.01002557
59Pancreatic cancer_Homo sapiens_hsa052121.00622610
60Insulin secretion_Homo sapiens_hsa049110.99894122
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99079633
62Acute myeloid leukemia_Homo sapiens_hsa052210.98957961
63Axon guidance_Homo sapiens_hsa043600.95280980
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.95140280
65Glioma_Homo sapiens_hsa052140.95126965
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.94939308
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92566200
68Fructose and mannose metabolism_Homo sapiens_hsa000510.92528892
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90436502
70Olfactory transduction_Homo sapiens_hsa047400.87744682
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87480879
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87056152
73N-Glycan biosynthesis_Homo sapiens_hsa005100.86090294
74Bladder cancer_Homo sapiens_hsa052190.85988600
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84847785
76Choline metabolism in cancer_Homo sapiens_hsa052310.83641382
77Hepatitis B_Homo sapiens_hsa051610.82764028
78Fatty acid biosynthesis_Homo sapiens_hsa000610.82284775
79Chemical carcinogenesis_Homo sapiens_hsa052040.82087136
80Glycerolipid metabolism_Homo sapiens_hsa005610.81658368
81Prostate cancer_Homo sapiens_hsa052150.80363880
82Pyrimidine metabolism_Homo sapiens_hsa002400.79824884
83Hippo signaling pathway_Homo sapiens_hsa043900.78811235
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77206450
85Estrogen signaling pathway_Homo sapiens_hsa049150.77163490
86Herpes simplex infection_Homo sapiens_hsa051680.75034332
87Epstein-Barr virus infection_Homo sapiens_hsa051690.75011490
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74998405
89Hedgehog signaling pathway_Homo sapiens_hsa043400.73546169
90Salivary secretion_Homo sapiens_hsa049700.72995028
91Pathways in cancer_Homo sapiens_hsa052000.72610026
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71117124
93Vitamin digestion and absorption_Homo sapiens_hsa049770.70845365
94Caffeine metabolism_Homo sapiens_hsa002320.70572338
95Calcium signaling pathway_Homo sapiens_hsa040200.70118284
96Glutamatergic synapse_Homo sapiens_hsa047240.70023993
97Proteoglycans in cancer_Homo sapiens_hsa052050.69590851
98Insulin signaling pathway_Homo sapiens_hsa049100.69418288
99Antigen processing and presentation_Homo sapiens_hsa046120.67208144
100Sphingolipid metabolism_Homo sapiens_hsa006000.66127264
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.65390370
102Wnt signaling pathway_Homo sapiens_hsa043100.65081509
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65076341
104ECM-receptor interaction_Homo sapiens_hsa045120.64689267
105Bile secretion_Homo sapiens_hsa049760.64187722
106Circadian entrainment_Homo sapiens_hsa047130.62601585
107Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62596319
108Cocaine addiction_Homo sapiens_hsa050300.62431306
109VEGF signaling pathway_Homo sapiens_hsa043700.62140459
110Glucagon signaling pathway_Homo sapiens_hsa049220.60386446
111Selenocompound metabolism_Homo sapiens_hsa004500.60287757
112Tryptophan metabolism_Homo sapiens_hsa003800.60017521
113Phenylalanine metabolism_Homo sapiens_hsa003600.59653751
114Apoptosis_Homo sapiens_hsa042100.58555521
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58444339
116Thyroid cancer_Homo sapiens_hsa052160.58343370
117Gastric acid secretion_Homo sapiens_hsa049710.57918538
118Insulin resistance_Homo sapiens_hsa049310.57478347
119AMPK signaling pathway_Homo sapiens_hsa041520.57220099
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56694053
121Adherens junction_Homo sapiens_hsa045200.56646802
122Basal transcription factors_Homo sapiens_hsa030220.55771793
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.55300968
124GnRH signaling pathway_Homo sapiens_hsa049120.55034750
125Dopaminergic synapse_Homo sapiens_hsa047280.53994379
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.52758675
127Melanogenesis_Homo sapiens_hsa049160.52342150
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51978636
129Prolactin signaling pathway_Homo sapiens_hsa049170.51804096
130Cholinergic synapse_Homo sapiens_hsa047250.51393715
131Butanoate metabolism_Homo sapiens_hsa006500.51025604
132Focal adhesion_Homo sapiens_hsa045100.49552372
133Tyrosine metabolism_Homo sapiens_hsa003500.49209120
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.48717447
135Dorso-ventral axis formation_Homo sapiens_hsa043200.47402912
136Toxoplasmosis_Homo sapiens_hsa051450.47332903
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46934934
138FoxO signaling pathway_Homo sapiens_hsa040680.46262092
139B cell receptor signaling pathway_Homo sapiens_hsa046620.46149618
140Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45076293
141Inositol phosphate metabolism_Homo sapiens_hsa005620.45014674
142Purine metabolism_Homo sapiens_hsa002300.44857936
143Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44417273
144Chemokine signaling pathway_Homo sapiens_hsa040620.44311218
145Gap junction_Homo sapiens_hsa045400.43944386
146Tight junction_Homo sapiens_hsa045300.43810141
147Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43527492
148ErbB signaling pathway_Homo sapiens_hsa040120.43377317
149Morphine addiction_Homo sapiens_hsa050320.41437683
150PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41311088
151Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40727552
152RNA polymerase_Homo sapiens_hsa030200.40070339
153Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39710530
154NF-kappa B signaling pathway_Homo sapiens_hsa040640.39353918
155Arachidonic acid metabolism_Homo sapiens_hsa005900.37256938

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