WDR91

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)9.38687965
2polyketide metabolic process (GO:0030638)9.38687965
3doxorubicin metabolic process (GO:0044598)9.38687965
4ncRNA 3-end processing (GO:0043628)6.93316862
5aminoglycoside antibiotic metabolic process (GO:0030647)6.35975925
6positive regulation of gamma-delta T cell activation (GO:0046645)6.08758813
7maintenance of protein location in nucleus (GO:0051457)5.83890381
8ribosomal small subunit biogenesis (GO:0042274)5.72446826
9regulation of response to osmotic stress (GO:0047484)5.42545798
10regulation of mammary gland epithelial cell proliferation (GO:0033599)5.32861916
11regulation of gamma-delta T cell activation (GO:0046643)5.30170585
12protein localization to kinetochore (GO:0034501)5.24266976
13cytidine deamination (GO:0009972)5.08703269
14cytidine metabolic process (GO:0046087)5.08703269
15cytidine catabolic process (GO:0006216)5.08703269
16somite rostral/caudal axis specification (GO:0032525)5.04459611
17regulation of gamma-delta T cell differentiation (GO:0045586)5.02244596
18regulation of telomere maintenance via telomerase (GO:0032210)4.99782016
19negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.93109786
20regulation of B cell receptor signaling pathway (GO:0050855)4.93026801
21regulation of MHC class I biosynthetic process (GO:0045343)4.86957925
22regulation of nuclear cell cycle DNA replication (GO:0033262)4.86870385
23negative regulation of telomerase activity (GO:0051974)4.78418922
24histone H4-K8 acetylation (GO:0043982)4.70173596
25histone H4-K5 acetylation (GO:0043981)4.70173596
26NADH metabolic process (GO:0006734)4.63860445
27interferon-gamma production (GO:0032609)4.58132227
28regulation of interleukin-12 biosynthetic process (GO:0045075)4.56416968
29negative regulation of epidermis development (GO:0045683)4.41908457
30histone H4 deacetylation (GO:0070933)4.34733127
31negative regulation of cell cycle G2/M phase transition (GO:1902750)4.33034168
32macrophage activation involved in immune response (GO:0002281)4.31772498
33positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.25373144
34defense response to protozoan (GO:0042832)4.25179105
35histone H4-K12 acetylation (GO:0043983)4.19622827
36muscle organ morphogenesis (GO:0048644)4.14686285
37rRNA transcription (GO:0009303)4.10646118
38negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.08947966
39negative regulation of cell killing (GO:0031342)4.07421338
40negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.07421338
41mitotic sister chromatid segregation (GO:0000070)4.00072531
42B cell receptor signaling pathway (GO:0050853)3.98579742
43production of molecular mediator involved in inflammatory response (GO:0002532)3.97740344
44response to protozoan (GO:0001562)3.97681535
45negative regulation of interleukin-12 production (GO:0032695)3.95497136
46protein localization to chromosome, centromeric region (GO:0071459)3.90827769
47positive regulation of chemokine secretion (GO:0090197)3.85702539
48hormone catabolic process (GO:0042447)3.85059948
49regulation of interferon-beta biosynthetic process (GO:0045357)3.82896941
50pyrimidine ribonucleoside catabolic process (GO:0046133)3.80762756
51regulation of sister chromatid cohesion (GO:0007063)3.78560078
52coenzyme catabolic process (GO:0009109)3.75707910
53regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.75415155
54regulation of T-helper 2 cell differentiation (GO:0045628)3.74599878
55negative regulation of phagocytosis (GO:0050765)3.73483231
56B cell mediated immunity (GO:0019724)3.72510665
57regulation of T-helper 1 cell differentiation (GO:0045625)3.71296808
58response to dietary excess (GO:0002021)3.69997681
59regulation of translation in response to stress (GO:0043555)3.69643715
60positive regulation of type 2 immune response (GO:0002830)3.67480278
61positive regulation of DNA-dependent DNA replication (GO:2000105)3.67443132
62mitochondrion distribution (GO:0048311)3.67287594
63histone H3 deacetylation (GO:0070932)3.63604987
64positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.62336197
65nucleoside transmembrane transport (GO:1901642)3.60562417
66positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.59628494
67heterochromatin organization (GO:0070828)3.59411942
68positive regulation of protein deacetylation (GO:0090312)3.55631960
69histone H4-K16 acetylation (GO:0043984)3.55219506
70T cell migration (GO:0072678)3.54945446
71cellular modified amino acid catabolic process (GO:0042219)3.52191145
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.50789315
73regulation of energy homeostasis (GO:2000505)3.50203460
74branching involved in mammary gland duct morphogenesis (GO:0060444)3.48049335
75phagocytosis, recognition (GO:0006910)3.47650931
76positive regulation of histone deacetylation (GO:0031065)3.46787240
77positive regulation of B cell differentiation (GO:0045579)3.45572527
78regulation of B cell differentiation (GO:0045577)3.44157188
79notochord development (GO:0030903)3.43539822
80microglial cell activation (GO:0001774)3.43279937
81detection of bacterium (GO:0016045)3.40713438
82phosphatidylglycerol biosynthetic process (GO:0006655)3.40639551
83intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.40446049
84detection of other organism (GO:0098543)3.40248200
85positive regulation of interferon-alpha production (GO:0032727)3.39393727
86positive regulation of interferon-beta production (GO:0032728)3.38554108
87antigen processing and presentation of endogenous antigen (GO:0019883)3.37712543
88negative regulation of Ras GTPase activity (GO:0034261)3.37588425
89activated T cell proliferation (GO:0050798)3.36757282
90negative regulation of telomere maintenance (GO:0032205)3.36045203
91nuclear pore complex assembly (GO:0051292)3.33303025
92negative regulation of T-helper cell differentiation (GO:0045623)3.31395123
93negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.31395123
94antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.30656047
95regulation of interferon-alpha production (GO:0032647)3.28068279
96chromatin assembly (GO:0031497)3.27245060
97response to muramyl dipeptide (GO:0032495)3.26656636
98sister chromatid segregation (GO:0000819)3.25154321
99immunoglobulin mediated immune response (GO:0016064)3.25002762
100T-helper 1 type immune response (GO:0042088)3.22797934
101transepithelial transport (GO:0070633)3.22011962
102negative regulation of epidermal cell differentiation (GO:0045605)3.20698140
103rRNA methylation (GO:0031167)3.19021989
104myeloid dendritic cell differentiation (GO:0043011)3.18636577
105regulation of apoptotic process involved in morphogenesis (GO:1902337)3.18417355
106interferon-gamma-mediated signaling pathway (GO:0060333)3.17838888
107CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.17552830
108DNA synthesis involved in DNA repair (GO:0000731)3.17426283
109cellular response to virus (GO:0098586)3.17179670
110phenol-containing compound catabolic process (GO:0019336)3.15110567
111regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.14788951
112phosphorylated carbohydrate dephosphorylation (GO:0046838)3.14095151
113inositol phosphate dephosphorylation (GO:0046855)3.14095151
114modulation by symbiont of host defense response (GO:0052031)3.13945782
115modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.13945782
116modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.13945782
117positive regulation by organism of defense response of other organism involved in symbiotic interact3.13945782
118modulation by symbiont of host immune response (GO:0052553)3.13945782
119positive regulation by symbiont of host defense response (GO:0052509)3.13945782
120positive regulation of humoral immune response (GO:0002922)3.12006336
121myeloid dendritic cell activation (GO:0001773)3.10828024
122tachykinin receptor signaling pathway (GO:0007217)3.09957038
123regulation of chemokine secretion (GO:0090196)3.08144210
124positive regulation of macrophage cytokine production (GO:0060907)3.06507935
125tricarboxylic acid metabolic process (GO:0072350)3.06277603
126positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.05518511
127response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.05200779
128response to host immune response (GO:0052572)3.05200779
129antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.05001696
130natural killer cell mediated immunity (GO:0002228)3.04871618
131natural killer cell mediated cytotoxicity (GO:0042267)3.04871618
1322-oxoglutarate metabolic process (GO:0006103)3.02866075
133pyrimidine-containing compound salvage (GO:0008655)3.02613597
134pyrimidine nucleoside salvage (GO:0043097)3.02613597
135primitive streak formation (GO:0090009)3.01927602
136regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.01496927
137regulation of natural killer cell mediated immunity (GO:0002715)3.01496927
138histone H3-K4 methylation (GO:0051568)3.00396831
139positive regulation of granulocyte differentiation (GO:0030854)2.99921317
140protein import into peroxisome matrix (GO:0016558)2.99501722
141type I interferon signaling pathway (GO:0060337)2.99454040
142cellular response to type I interferon (GO:0071357)2.99454040
143positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.98756761
144response to type I interferon (GO:0034340)2.98748304
145mRNA stabilization (GO:0048255)2.98286371
146RNA stabilization (GO:0043489)2.98286371
147positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.97906085
148response to peptidoglycan (GO:0032494)2.97875962
149regulation of cilium movement (GO:0003352)2.97165476
150negative regulation of interleukin-6 production (GO:0032715)2.96518367
151regulation of apoptotic cell clearance (GO:2000425)2.96401717
152positive regulation of tissue remodeling (GO:0034105)2.96102966
153negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.94853523
154negative regulation of erythrocyte differentiation (GO:0045647)2.94387165
155positive regulation of defense response to virus by host (GO:0002230)2.94292750
156pre-miRNA processing (GO:0031054)2.93370207
157positive regulation of developmental pigmentation (GO:0048087)2.91485424
158quinone metabolic process (GO:1901661)2.90361797
159negative regulation of bone resorption (GO:0045779)2.90274735
160maintenance of protein localization in organelle (GO:0072595)2.89822178
161positive regulation of Notch signaling pathway (GO:0045747)2.89395553
162regulation of interferon-beta production (GO:0032648)2.89260364
163pore complex assembly (GO:0046931)2.88305778
164negative regulation of viral release from host cell (GO:1902187)2.87016788
165positive thymic T cell selection (GO:0045059)2.86986389
166regulation of interleukin-12 production (GO:0032655)2.86729895
167detection of external biotic stimulus (GO:0098581)2.86401312
168DNA replication checkpoint (GO:0000076)2.83959989
169establishment of endothelial barrier (GO:0061028)2.83739457
170retinoic acid receptor signaling pathway (GO:0048384)2.82192147
171intestinal epithelial cell development (GO:0060576)2.82130388
172modulation by symbiont of host cellular process (GO:0044068)2.80795476
173epithelial cell differentiation involved in prostate gland development (GO:0060742)2.79227387
174NLS-bearing protein import into nucleus (GO:0006607)2.78591313
175DNA replication-dependent nucleosome organization (GO:0034723)2.78526798
176DNA replication-dependent nucleosome assembly (GO:0006335)2.78526798
177regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.78217442
178macrophage activation (GO:0042116)2.77228101
179thymic T cell selection (GO:0045061)2.76725789
180tolerance induction (GO:0002507)2.75994270
181adaptation of signaling pathway (GO:0023058)2.75259295
182rRNA modification (GO:0000154)2.74490704
183epoxygenase P450 pathway (GO:0019373)2.74342085
184cell fate commitment involved in formation of primary germ layer (GO:0060795)2.74230300
185vagina development (GO:0060068)2.73711877
186negative regulation of interleukin-2 production (GO:0032703)2.73361240
187positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.72435053
188negative regulation of toll-like receptor signaling pathway (GO:0034122)2.71256688
189positive regulation of bone resorption (GO:0045780)2.71229339

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.94281034
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.90932815
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.59817819
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.59817819
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.59817819
6E2F7_22180533_ChIP-Seq_HELA_Human3.72420977
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.45998538
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.03978625
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.89342141
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.63363317
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.51835413
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.43856766
13SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.39246620
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.34606726
15RUNX_20019798_ChIP-Seq_JUKART_Human2.32999603
16VDR_24763502_ChIP-Seq_THP-1_Human2.32531647
17SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.25100271
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.23336887
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.22378439
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.19921148
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.14940068
22IRF8_22096565_ChIP-ChIP_GC-B_Human2.13817983
23VDR_24787735_ChIP-Seq_THP-1_Human2.10876740
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.10139513
25TCF3_18692474_ChIP-Seq_MESCs_Mouse2.01764079
26SCL_19346495_ChIP-Seq_HPC-7_Human1.97715847
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88920317
28TCF3_18692474_ChIP-Seq_MEFs_Mouse1.85295250
29MYB_26560356_Chip-Seq_TH2_Human1.82682342
30EGR1_19032775_ChIP-ChIP_M12_Human1.82399363
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.81154398
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.81015557
33* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80923011
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.76769095
35* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74112495
36VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.74006044
37* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.73033143
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71024864
39GATA1_19941827_ChIP-Seq_MEL_Mouse1.69777492
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66755596
41UTX_26944678_Chip-Seq_JUKART_Human1.65265892
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.65211423
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.65072257
44NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.64933369
45NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.64775084
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.64425817
47MYC_22102868_ChIP-Seq_BL_Human1.60416738
48MAF_26560356_Chip-Seq_TH2_Human1.58817916
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58455004
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57991015
51GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.56729136
52NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.50138674
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.49848373
54TCF7_22412390_ChIP-Seq_EML_Mouse1.47037123
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43330937
56* BCL6_27268052_Chip-Seq_Bcells_Human1.42374817
57SPI1_23127762_ChIP-Seq_K562_Human1.38682779
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37826260
59GATA3_27048872_Chip-Seq_THYMUS_Human1.37108170
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36818795
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36414722
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33379193
63* BCOR_27268052_Chip-Seq_Bcells_Human1.33078255
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30707189
65NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29234959
66CDX2_20551321_ChIP-Seq_CACO-2_Human1.28922851
67GATA1_19941826_ChIP-Seq_K562_Human1.28534095
68TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.28527153
69IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.28337554
70POU5F1_16518401_ChIP-PET_MESCs_Mouse1.28167057
71NANOG_18692474_ChIP-Seq_MESCs_Mouse1.27329312
72SA1_27219007_Chip-Seq_ERYTHROID_Human1.26586964
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25936812
74MYB_21317192_ChIP-Seq_ERMYB_Mouse1.24932375
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23657040
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23602905
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.22689183
78IRF1_19129219_ChIP-ChIP_H3396_Human1.22679514
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21590560
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21483275
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20265917
82AR_21572438_ChIP-Seq_LNCaP_Human1.20056350
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19989044
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.18645391
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17827739
86FOXO3_23340844_ChIP-Seq_DLD1_Human1.17181017
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16888673
88NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15345440
89TP63_17297297_ChIP-ChIP_HaCaT_Human1.14017764
90* NCOR1_26117541_ChIP-Seq_K562_Human1.13807816
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13379736
92CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12737244
93NANOG_18692474_ChIP-Seq_MEFs_Mouse1.12058448
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11075547
95MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10526218
96PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.10195968
97VDR_21846776_ChIP-Seq_THP-1_Human1.09935786
98RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09917858
99POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.09851934
100CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09498367
101SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09054755
102GATA1_22025678_ChIP-Seq_K562_Human1.08767294
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07858374
104RUNX1_22412390_ChIP-Seq_EML_Mouse1.07507393
105KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07479325
106BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06788292
107ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06346623
108KDM2B_26808549_Chip-Seq_JURKAT_Human1.05816090
109SPI1_23547873_ChIP-Seq_NB4_Human1.05419603
110EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04891572
111* SMRT_27268052_Chip-Seq_Bcells_Human1.04572822
112SPI1_20517297_ChIP-Seq_HL60_Human1.03757565
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03524984
114SOX2_18692474_ChIP-Seq_MESCs_Mouse1.03075741
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02538407
116LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02119594
117TP53_22127205_ChIP-Seq_IMR90_Human1.01533235
118SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01456837
119SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01366192
120ESR1_20079471_ChIP-ChIP_T-47D_Human1.00229670
121GATA2_19941826_ChIP-Seq_K562_Human0.98935041
122PHF8_20622854_ChIP-Seq_HELA_Human0.98750539
123* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97916169
124DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97274386
125BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97005631
126MYB_26560356_Chip-Seq_TH1_Human0.96842500
127E2F1_17053090_ChIP-ChIP_MCF-7_Human0.96752978
128GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95815788
129ESR2_21235772_ChIP-Seq_MCF-7_Human0.95650578
130* P300_27268052_Chip-Seq_Bcells_Human0.95226475
131SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94715437
132THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94370351
133NANOG_16518401_ChIP-PET_MESCs_Mouse0.93972764
134TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93770420
135PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93394131
136KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93279389
137CTCF_21964334_ChIP-Seq_BJAB-B_Human0.91954616
138TFEB_21752829_ChIP-Seq_HELA_Human0.91640653
139SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90463434
140P68_20966046_ChIP-Seq_HELA_Human0.89979442
141PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89465207
142ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89083460
143GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89068290
144POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88419603
145CTCF_26484167_Chip-Seq_Bcells_Mouse0.87383909
146MAF_26560356_Chip-Seq_TH1_Human0.86888282
147OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85934071
148RACK7_27058665_Chip-Seq_MCF-7_Human0.83884064
149IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.83859248
150CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83331643
151NOTCH1_21737748_ChIP-Seq_TLL_Human0.82554510
152YY1_21170310_ChIP-Seq_MESCs_Mouse0.81333901
153MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.79383232
154KDM2B_26808549_Chip-Seq_K562_Human0.78270053
155ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.77418995
156KDM2B_26808549_Chip-Seq_DND41_Human0.77162978
157SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77042281
158LXR_22292898_ChIP-Seq_THP-1_Human0.76332508
159POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.75141360
160SMC4_20622854_ChIP-Seq_HELA_Human0.75004743
161CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73747170
162EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.73657500
163TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.73430175

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.91600629
2MP0003011_delayed_dark_adaptation3.96499249
3MP0001873_stomach_inflammation3.72520531
4MP0005075_abnormal_melanosome_morpholog3.57815383
5MP0004264_abnormal_extraembryonic_tissu3.49992406
6MP0005257_abnormal_intraocular_pressure3.24433344
7MP0000569_abnormal_digit_pigmentation3.15518233
8MP0004858_abnormal_nervous_system2.96852088
9MP0006082_CNS_inflammation2.87639422
10MP0006292_abnormal_olfactory_placode2.81238225
11MP0003879_abnormal_hair_cell2.73608278
12MP0003705_abnormal_hypodermis_morpholog2.63378668
13MP0003183_abnormal_peptide_metabolism2.61250180
14MP0002332_abnormal_exercise_endurance2.58244131
15MP0003890_abnormal_embryonic-extraembry2.56316484
16MP0003172_abnormal_lysosome_physiology2.47980799
17MP0008057_abnormal_DNA_replication2.32126649
18MP0000015_abnormal_ear_pigmentation2.20377266
19MP0001727_abnormal_embryo_implantation2.13989645
20MP0005394_taste/olfaction_phenotype2.13252720
21MP0005499_abnormal_olfactory_system2.13252720
22MP0003763_abnormal_thymus_physiology2.02985997
23MP0002933_joint_inflammation2.00077961
24MP0001835_abnormal_antigen_presentation1.96090958
25MP0009333_abnormal_splenocyte_physiolog1.93645233
26MP0002148_abnormal_hypersensitivity_rea1.90891614
27MP0001851_eye_inflammation1.90428166
28MP0001533_abnormal_skeleton_physiology1.85668720
29MP0010352_gastrointestinal_tract_polyps1.76575055
30MP0004381_abnormal_hair_follicle1.76187785
31MP0003300_gastrointestinal_ulcer1.69498774
32MP0008961_abnormal_basal_metabolism1.69453886
33MP0006035_abnormal_mitochondrial_morpho1.68598890
34MP0003724_increased_susceptibility_to1.66671415
35MP0003436_decreased_susceptibility_to1.64545762
36MP0005058_abnormal_lysosome_morphology1.58806093
37MP0002998_abnormal_bone_remodeling1.57377288
38MP0002277_abnormal_respiratory_mucosa1.56943179
39MP0002138_abnormal_hepatobiliary_system1.56129083
40MP0002396_abnormal_hematopoietic_system1.55271946
41MP0001545_abnormal_hematopoietic_system1.50906141
42MP0005397_hematopoietic_system_phenotyp1.50906141
43MP0004957_abnormal_blastocyst_morpholog1.49205158
44MP0005387_immune_system_phenotype1.44229049
45MP0001790_abnormal_immune_system1.44229049
46MP0001845_abnormal_inflammatory_respons1.42650076
47MP0005464_abnormal_platelet_physiology1.41669131
48MP0001800_abnormal_humoral_immune1.41404893
49MP0001672_abnormal_embryogenesis/_devel1.39298974
50MP0005380_embryogenesis_phenotype1.39298974
51MP0000372_irregular_coat_pigmentation1.37288394
52MP0001663_abnormal_digestive_system1.35115862
53MP0005000_abnormal_immune_tolerance1.33116434
54MP0003448_altered_tumor_morphology1.31199665
55MP0002088_abnormal_embryonic_growth/wei1.30271893
56MP0003122_maternal_imprinting1.30053110
57MP0008469_abnormal_protein_level1.28822043
58MP0003984_embryonic_growth_retardation1.27181287
59MP0003121_genomic_imprinting1.26911759
60MP0009764_decreased_sensitivity_to1.26499637
61MP0001849_ear_inflammation1.25367895
62MP0000703_abnormal_thymus_morphology1.22376719
63MP0002452_abnormal_antigen_presenting1.19437052
64MP0009840_abnormal_foam_cell1.17499369
65MP0005310_abnormal_salivary_gland1.16636243
66MP0005025_abnormal_response_to1.15411985
67MP0002092_abnormal_eye_morphology1.15291719
68MP0000689_abnormal_spleen_morphology1.14797130
69MP0010155_abnormal_intestine_physiology1.14750716
70MP0003938_abnormal_ear_development1.10532320
71MP0001293_anophthalmia1.09760755
72MP0000685_abnormal_immune_system1.09097386
73MP0002723_abnormal_immune_serum1.09000999
74MP0000371_diluted_coat_color1.08093824
75MP0000350_abnormal_cell_proliferation1.04221970
76MP0002405_respiratory_system_inflammati1.03725274
77MP0004947_skin_inflammation1.03585052
78MP0009765_abnormal_xenobiotic_induced1.03530721
79MP0002419_abnormal_innate_immunity1.02615222
80MP0002653_abnormal_ependyma_morphology1.01586441
81MP0002722_abnormal_immune_system1.00688821
82MP0001819_abnormal_immune_cell1.00311886
83MP0003077_abnormal_cell_cycle1.00296055
84MP0002420_abnormal_adaptive_immunity0.99491460
85MP0000604_amyloidosis0.99019941
86MP0009278_abnormal_bone_marrow0.98604553
87MP0002086_abnormal_extraembryonic_tissu0.97180962
88MP0005671_abnormal_response_to0.94228010
89MP0003191_abnormal_cellular_cholesterol0.92682939
90MP0001915_intracranial_hemorrhage0.92524526
91MP0000716_abnormal_immune_system0.92146778
92MP0003111_abnormal_nucleus_morphology0.91587127
93MP0002095_abnormal_skin_pigmentation0.91457943
94MP0005171_absent_coat_pigmentation0.89709978
95MP0002398_abnormal_bone_marrow0.89279585
96MP0000313_abnormal_cell_death0.89054541
97MP0002127_abnormal_cardiovascular_syste0.88877061
98MP0002429_abnormal_blood_cell0.87843164
99MP0002139_abnormal_hepatobiliary_system0.86728727
100MP0000490_abnormal_crypts_of0.86520738
101MP0008770_decreased_survivor_rate0.85859611
102MP0005197_abnormal_uvea_morphology0.85762125
103MP0003195_calcinosis0.85190189
104MP0002970_abnormal_white_adipose0.84826223
105MP0003566_abnormal_cell_adhesion0.84589616
106MP0005381_digestive/alimentary_phenotyp0.84138751
107MP0005266_abnormal_metabolism0.84127668
108MP0000609_abnormal_liver_physiology0.81160445
109MP0002166_altered_tumor_susceptibility0.80692200
110MP0000343_altered_response_to0.80082365
111MP0004808_abnormal_hematopoietic_stem0.79143366
112MP0000858_altered_metastatic_potential0.79137594
113MP0005390_skeleton_phenotype0.79099941
114MP0003656_abnormal_erythrocyte_physiolo0.78970998
115MP0004883_abnormal_blood_vessel0.78867219
116MP0003303_peritoneal_inflammation0.78560490
117MP0005174_abnormal_tail_pigmentation0.78428972
118MP0005023_abnormal_wound_healing0.77999978
119MP0002132_abnormal_respiratory_system0.77011987
120MP0005319_abnormal_enzyme/_coenzyme0.76168419
121MP0004510_myositis0.75686168
122MP0008260_abnormal_autophagy0.74712493
123MP0000678_abnormal_parathyroid_gland0.74326168
124MP0002075_abnormal_coat/hair_pigmentati0.74221232
125MP0000383_abnormal_hair_follicle0.74055080
126MP0005384_cellular_phenotype0.71773452
127MP0001243_abnormal_dermal_layer0.71370803
128MP0003828_pulmonary_edema0.70184492
129MP0005167_abnormal_blood-brain_barrier0.70177124
130MP0005621_abnormal_cell_physiology0.69846771
131MP0009785_altered_susceptibility_to0.69579218
132MP0003075_altered_response_to0.68512160
133MP0003866_abnormal_defecation0.67868047
134MP0005451_abnormal_body_composition0.66660203
135MP0009763_increased_sensitivity_to0.65949904
136MP0002085_abnormal_embryonic_tissue0.65220068
137MP0003453_abnormal_keratinocyte_physiol0.64645404
138MP0002928_abnormal_bile_duct0.64560082
139MP0000432_abnormal_head_morphology0.63467886
140MP0009115_abnormal_fat_cell0.63219745
141MP0003091_abnormal_cell_migration0.63053814
142MP0001853_heart_inflammation0.62260646
143MP0003690_abnormal_glial_cell0.62231669
144MP0001324_abnormal_eye_pigmentation0.61842813
145MP0003787_abnormal_imprinting0.61193998
146MP0003795_abnormal_bone_structure0.60857941
147MP0001986_abnormal_taste_sensitivity0.59590775
148MP0003136_yellow_coat_color0.57710529
149MP0005220_abnormal_exocrine_pancreas0.55842956
150MP0000920_abnormal_myelination0.54726366
151MP0000249_abnormal_blood_vessel0.52735142
152MP0002163_abnormal_gland_morphology0.51119235
153MP0005379_endocrine/exocrine_gland_phen0.50082129
154MP0003045_fibrosis0.49271548
155MP0002822_catalepsy0.49135800
156MP0005166_decreased_susceptibility_to0.49073350

Predicted human phenotypes

RankGene SetZ-score
1Metaphyseal cupping (HP:0003021)7.90689111
2Striae distensae (HP:0001065)6.71972546
3Hypochromic microcytic anemia (HP:0004840)6.15953634
4Round ear (HP:0100830)6.07984244
5Bilateral microphthalmos (HP:0007633)6.07630396
6Abnormality of macular pigmentation (HP:0008002)5.93309585
7Cupped ribs (HP:0000887)5.74527579
8Constricted visual fields (HP:0001133)5.72357796
9Cone-rod dystrophy (HP:0000548)5.40953004
10Volvulus (HP:0002580)5.10934805
11Hepatoblastoma (HP:0002884)4.68857747
12Toxemia of pregnancy (HP:0100603)4.44797970
13Multiple enchondromatosis (HP:0005701)4.36432226
14Attenuation of retinal blood vessels (HP:0007843)4.08214785
15Chromosomal breakage induced by crosslinking agents (HP:0003221)4.07340959
16Abnormality of liposaccharide metabolism (HP:0010968)3.93358861
17Abnormality of glycosphingolipid metabolism (HP:0004343)3.93358861
18Abnormality of glycolipid metabolism (HP:0010969)3.93358861
19Abnormality of the lower motor neuron (HP:0002366)3.91711487
20Rib fusion (HP:0000902)3.79061851
21Decreased electroretinogram (ERG) amplitude (HP:0000654)3.75552719
22Ependymoma (HP:0002888)3.69795808
23Gastrointestinal stroma tumor (HP:0100723)3.64043658
24Chromsome breakage (HP:0040012)3.44035957
25Mediastinal lymphadenopathy (HP:0100721)3.37282413
26Upper motor neuron abnormality (HP:0002127)3.37147412
27Ovoid vertebral bodies (HP:0003300)3.22977049
28Aplasia/Hypoplasia of the fovea (HP:0008060)3.21172402
29Hypoplasia of the fovea (HP:0007750)3.21172402
30Oligodontia (HP:0000677)3.19749046
31Eczematoid dermatitis (HP:0000976)3.18336111
32Inflammation of the large intestine (HP:0002037)3.17586103
33Neoplasm of striated muscle (HP:0009728)3.17158459
34Recurrent sinusitis (HP:0011108)3.16812611
35Hematochezia (HP:0002573)3.16374613
36Femoral bowing (HP:0002980)3.13371572
37Large earlobe (HP:0009748)3.10089016
38Tibial bowing (HP:0002982)3.09438890
39Intestinal fistula (HP:0100819)3.08982251
40Testicular atrophy (HP:0000029)3.02159823
41Abnormality of macrophages (HP:0004311)3.00061488
42Gastrointestinal inflammation (HP:0004386)2.99371061
43Progressive visual loss (HP:0000529)2.98777476
44Vasculitis (HP:0002633)2.97604628
45Albinism (HP:0001022)2.96896424
46Broad nasal tip (HP:0000455)2.96408897
47Lack of skin elasticity (HP:0100679)2.95109677
48Rhabdomyosarcoma (HP:0002859)2.94069081
49Obstructive lung disease (HP:0006536)2.91790939
50Chronic obstructive pulmonary disease (HP:0006510)2.91790939
51IgM deficiency (HP:0002850)2.91248580
52Recurrent otitis media (HP:0000403)2.90693152
53Aplasia/Hypoplasia of the macula (HP:0008059)2.90508063
54Colitis (HP:0002583)2.89675550
55Rectovaginal fistula (HP:0000143)2.89604179
56Rectal fistula (HP:0100590)2.89604179
57Nephroblastoma (Wilms tumor) (HP:0002667)2.88998357
58Abnormality of the salivary glands (HP:0010286)2.86512303
59Fused cervical vertebrae (HP:0002949)2.86491098
60Recurrent gram-negative bacterial infections (HP:0005420)2.79693942
61Elevated erythrocyte sedimentation rate (HP:0003565)2.79057769
62Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.78336454
63Meningitis (HP:0001287)2.78223565
64Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.74143757
65Abnormality of lateral ventricle (HP:0030047)2.72236648
66Abnormality of the astrocytes (HP:0100707)2.68721334
67Astrocytoma (HP:0009592)2.68721334
68Hypochromic anemia (HP:0001931)2.67738796
69Recurrent fungal infections (HP:0002841)2.67700306
70Embryonal renal neoplasm (HP:0011794)2.62625860
71Coxa vara (HP:0002812)2.61903511
72Aplasia/Hypoplasia affecting the retina (HP:0008061)2.60226743
73Cheilitis (HP:0100825)2.59641703
74Restrictive lung disease (HP:0002091)2.58802249
75Vaginal fistula (HP:0004320)2.57809523
76Global brain atrophy (HP:0002283)2.54446305
77Severe visual impairment (HP:0001141)2.54323423
78Recurrent viral infections (HP:0004429)2.53576363
79Recurrent abscess formation (HP:0002722)2.49101774
80Agammaglobulinemia (HP:0004432)2.47011546
81Partial duplication of thumb phalanx (HP:0009944)2.45251110
82Anomalous pulmonary venous return (HP:0010772)2.42032945
83Supernumerary nipples (HP:0002558)2.41402667
84Gingivitis (HP:0000230)2.40698978
85Systemic lupus erythematosus (HP:0002725)2.39876369
86Combined immunodeficiency (HP:0005387)2.37793870
87Emphysema (HP:0002097)2.36332273
88Impulsivity (HP:0100710)2.35641243
89Abnormal cartilage morphology (HP:0002763)2.33064949
90Abnormality of the fovea (HP:0000493)2.32989810
91Widely spaced teeth (HP:0000687)2.31674839
92Orchitis (HP:0100796)2.31539255
93Reduced antithrombin III activity (HP:0001976)2.31276732
94Hyperinsulinemic hypoglycemia (HP:0000825)2.30283510
95Horizontal nystagmus (HP:0000666)2.29899373
96Cellulitis (HP:0100658)2.29428745
97Hand muscle atrophy (HP:0009130)2.25485518
98Dysostosis multiplex (HP:0000943)2.24548775
99Recurrent skin infections (HP:0001581)2.24526718
100Hepatosplenomegaly (HP:0001433)2.24494457
101Aplasia/Hypoplasia of the uvula (HP:0010293)2.24240458
102Prolonged bleeding time (HP:0003010)2.22955303
103Blepharitis (HP:0000498)2.22784761
104Villous atrophy (HP:0011473)2.22605848
105Abnormality of small intestinal villus morphology (HP:0011472)2.22605848
106Recurrent bacterial skin infections (HP:0005406)2.21464724
107Absent frontal sinuses (HP:0002688)2.20195548
108Optic neuritis (HP:0100653)2.18049425
109Retrobulbar optic neuritis (HP:0100654)2.18049425
110Meckel diverticulum (HP:0002245)2.17853715
111Sensory axonal neuropathy (HP:0003390)2.17304497
112Increased connective tissue (HP:0009025)2.16804568
113Spastic tetraparesis (HP:0001285)2.16345291
114Lymphedema (HP:0001004)2.16031860
115Pseudobulbar signs (HP:0002200)2.15608884
116Upper limb muscle weakness (HP:0003484)2.15364449
117Pulmonary infiltrates (HP:0002113)2.14954266
118Amyotrophic lateral sclerosis (HP:0007354)2.14953053
119Short humerus (HP:0005792)2.14739936
120Preauricular skin tag (HP:0000384)2.13714783
121Periauricular skin pits (HP:0100277)2.13232869
122Preauricular pit (HP:0004467)2.13232869
123Brushfield spots (HP:0001088)2.12883111
124Ragged-red muscle fibers (HP:0003200)2.12489936
125Abnormal delayed hypersensitivity skin test (HP:0002963)2.11095709
126Lymphopenia (HP:0001888)2.10561474
127Generalized hypotonia (HP:0001290)2.10299559
128Aplasia/hypoplasia of the humerus (HP:0006507)2.09639628
129Recurrent cutaneous fungal infections (HP:0011370)2.09264716
130Chronic mucocutaneous candidiasis (HP:0002728)2.09264716
131Decreased muscle mass (HP:0003199)2.09017004
132Increased IgE level (HP:0003212)2.08376524
133Abnormality of chromosome segregation (HP:0002916)2.07688215
134Autoimmune hemolytic anemia (HP:0001890)2.07569832
135Gingival bleeding (HP:0000225)2.07089852
136Skin nodule (HP:0200036)2.06867839
137Vacuolated lymphocytes (HP:0001922)2.06455503
138Aplasia/Hypoplasia of the earlobes (HP:0009906)2.06384435
139Pulmonary fibrosis (HP:0002206)2.06297611
140Autoimmune thrombocytopenia (HP:0001973)2.06238873
141Abnormality of the intrinsic pathway (HP:0010989)2.04879790
142Abnormality of the ileum (HP:0001549)2.04123486
143Hypertensive crisis (HP:0100735)2.02470764
144Hypopigmentation of the fundus (HP:0007894)2.02370012
145Partial duplication of the phalanx of hand (HP:0009999)2.01233541
146Shawl scrotum (HP:0000049)2.00266986
147Abnormality of the pulmonary veins (HP:0011718)1.98912009
148Premature loss of primary teeth (HP:0006323)1.98877138
149Abnormality of the musculature of the hand (HP:0001421)1.97850849
150IgA deficiency (HP:0002720)1.96062583
151Recurrent pneumonia (HP:0006532)1.94952587
152Skin tags (HP:0010609)1.92620548
153Abnormality of cells of the lymphoid lineage (HP:0012140)1.91858923
154Glioma (HP:0009733)1.91014413
155Recurrent bronchitis (HP:0002837)1.89439172
156Myositis (HP:0100614)1.89415300
157Trismus (HP:0000211)1.89196279
158Amyloidosis (HP:0011034)1.89033774
159Difficulty running (HP:0009046)1.88441654
160Bifid tongue (HP:0010297)1.88118718
161Urticaria (HP:0001025)1.87949088
162Spontaneous hematomas (HP:0007420)1.86527646
163Increased cerebral lipofuscin (HP:0011813)1.84699709
164Tetraplegia (HP:0002445)1.84444651
165Verrucae (HP:0200043)1.83659323
166Papilloma (HP:0012740)1.83659323
167Upper limb amyotrophy (HP:0009129)1.83394198
168Distal upper limb amyotrophy (HP:0007149)1.83394198
169Nasal polyposis (HP:0100582)1.81487812
170Spinal muscular atrophy (HP:0007269)1.79299700
171Freckling (HP:0001480)1.79240617
172Hypoplastic ilia (HP:0000946)1.79128499
173Limited elbow extension (HP:0001377)1.78948827
174Truncal obesity (HP:0001956)1.78711774
175Ulnar bowing (HP:0003031)1.78710178
176Abnormality of the fingertips (HP:0001211)1.78677500
177Glomerulonephritis (HP:0000099)1.78658866
178Abnormal lung lobation (HP:0002101)1.78432192
179Purpura (HP:0000979)1.77793420
180Hyperthyroidism (HP:0000836)1.77702349
181Long eyelashes (HP:0000527)1.77592044
182Small hand (HP:0200055)1.76701414
183Periodontitis (HP:0000704)1.76444733
184Ocular albinism (HP:0001107)1.74779133
185Short 5th finger (HP:0009237)1.71541095
186Nasolacrimal duct obstruction (HP:0000579)1.70806661
187Uterine leiomyosarcoma (HP:0002891)1.70390166
188Leiomyosarcoma (HP:0100243)1.70390166
189Microvesicular hepatic steatosis (HP:0001414)1.68333194

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.34868538
2ERN14.70293215
3GRK54.27876771
4FES4.18536065
5GRK63.83801496
6CSF1R3.33824965
7TEC3.08291777
8TGFBR22.61784791
9GRK12.56073997
10ADRBK22.51076072
11MAPK72.37952363
12STK102.29023994
13TTK2.15685799
14MATK2.05954732
15GRK72.05910148
16FGR1.90371776
17TYRO31.85023559
18WNK11.79606501
19MOS1.76280460
20CDK191.63067105
21BTK1.62969706
22RET1.54248155
23MAP3K101.44359187
24IKBKB1.36047317
25CAMK41.35644213
26MARK21.30298006
27IRAK31.26029427
28KIT1.21495142
29TNK21.17968356
30FGFR31.14101596
31CSK1.13411586
32BLK1.13373698
33NTRK11.13301732
34TYK21.10912056
35PRKG21.09090876
36PAK41.08156302
37CDK71.05795595
38MAP3K141.05592550
39SIK21.05275630
40HIPK20.97733826
41CDK30.94390916
42CHEK20.94030786
43TESK20.92089837
44RIPK40.86963848
45CHUK0.84000586
46MAP4K10.83737270
47BCKDK0.82868089
48EPHA20.82143232
49MAPK120.79670436
50PRKCQ0.78659935
51CDC42BPA0.78437592
52TAOK30.77697307
53EIF2AK20.76916629
54AKT30.76720169
55MAP3K70.75022382
56MAP3K130.74377185
57MTOR0.70911248
58MAP2K40.70344757
59PLK10.70234656
60TXK0.69429033
61HCK0.68382902
62IRAK40.65549750
63ITK0.64435651
64NEK20.63535885
65PDPK10.62169813
66MAPK150.60945675
67SIK10.59920935
68TBK10.58139018
69ALK0.58125757
70ICK0.56945467
71CAMK1D0.56183738
72AKT20.55218828
73ADRBK10.54329359
74DDR20.54179780
75CHEK10.53869296
76RPS6KL10.53778007
77RPS6KC10.53778007
78JAK30.52601573
79RPS6KA60.52095906
80SIK30.51415568
81MAP3K110.50547179
82MAP3K10.50119414
83ERBB20.49160011
84STK40.49027679
85JAK10.48279769
86MAP2K30.48142480
87RPS6KB20.47965622
88SRC0.45397104
89BMX0.45157354
90NEK90.43341829
91BRD40.43048235
92PRKCD0.42994459
93FYN0.42545344
94JAK20.41749181
95IKBKE0.41210136
96PTK20.40499723
97PRKD20.40469634
98SGK20.39614694
99IGF1R0.39192301
100ZAP700.38106171
101PASK0.37917437
102LCK0.37652523
103IRAK10.37294382
104SYK0.37198155
105TLK10.36535646
106MAPK100.36527707
107IRAK20.35368156
108CAMKK10.34557871
109RPS6KA20.34270844
110PIM10.34261099
111CDK20.34182272
112FGFR40.34136819
113EGFR0.33752718
114MAP2K60.33422619
115PDGFRB0.33219394
116MAPK110.33163781
117CDK40.32402100
118MAP3K30.32220768
119GSK3A0.31691834
120ABL10.31188043
121INSR0.30675279
122TRIB30.29816005
123TAOK10.29198089
124RPS6KA10.28811304
125TTN0.28453600
126MAPK10.26842022
127RIPK10.26373907
128MARK30.26091520
129PKN10.26080530
130EEF2K0.24586721
131STK30.24347587
132TAOK20.23980238
133DAPK20.23843507
134DYRK1B0.23405571
135MAPK40.23353204
136ATM0.23193922
137EPHB10.23124522
138MAPK30.22541696
139PRKAA10.22197412
140SGK30.22116342
141STK380.19370057
142PDK10.19003327
143PRPF4B0.18743697
144LYN0.18237478

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.49514845
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.04199580
3Allograft rejection_Homo sapiens_hsa053303.32772768
4Graft-versus-host disease_Homo sapiens_hsa053323.11583552
5Autoimmune thyroid disease_Homo sapiens_hsa053203.01489224
6Fructose and mannose metabolism_Homo sapiens_hsa000512.82219409
7Asthma_Homo sapiens_hsa053102.76901621
8Type I diabetes mellitus_Homo sapiens_hsa049402.62698653
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.16788645
10Other glycan degradation_Homo sapiens_hsa005112.03180948
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.01451529
12Antigen processing and presentation_Homo sapiens_hsa046121.92029789
13Viral myocarditis_Homo sapiens_hsa054161.91903332
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.87036552
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.83467066
16Rheumatoid arthritis_Homo sapiens_hsa053231.82958703
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.82038866
18Galactose metabolism_Homo sapiens_hsa000521.80595882
19Arachidonic acid metabolism_Homo sapiens_hsa005901.76116705
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.71910252
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59015597
22mTOR signaling pathway_Homo sapiens_hsa041501.58062544
23Lysosome_Homo sapiens_hsa041421.57051454
24B cell receptor signaling pathway_Homo sapiens_hsa046621.55504098
25Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.49646427
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48022592
27Leishmaniasis_Homo sapiens_hsa051401.45614175
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.43882994
29Apoptosis_Homo sapiens_hsa042101.35838788
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32406294
31Staphylococcus aureus infection_Homo sapiens_hsa051501.30576319
32Acute myeloid leukemia_Homo sapiens_hsa052211.25446997
33Inositol phosphate metabolism_Homo sapiens_hsa005621.23278619
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17921367
35Systemic lupus erythematosus_Homo sapiens_hsa053221.17764777
36Complement and coagulation cascades_Homo sapiens_hsa046101.16967890
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14821853
38Linoleic acid metabolism_Homo sapiens_hsa005911.13182627
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12536390
40Osteoclast differentiation_Homo sapiens_hsa043801.12288797
41Tuberculosis_Homo sapiens_hsa051521.08656022
42Influenza A_Homo sapiens_hsa051641.07915040
43Phospholipase D signaling pathway_Homo sapiens_hsa040721.05644042
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99211273
45Herpes simplex infection_Homo sapiens_hsa051680.98651287
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97732108
47Malaria_Homo sapiens_hsa051440.97381750
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96185474
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92508514
50Prion diseases_Homo sapiens_hsa050200.90755795
51Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88825394
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.87565226
53Hepatitis B_Homo sapiens_hsa051610.86536488
54Hepatitis C_Homo sapiens_hsa051600.85709936
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85700241
56Lysine degradation_Homo sapiens_hsa003100.85043232
57One carbon pool by folate_Homo sapiens_hsa006700.85039454
58Caffeine metabolism_Homo sapiens_hsa002320.84987766
59MicroRNAs in cancer_Homo sapiens_hsa052060.84733005
60T cell receptor signaling pathway_Homo sapiens_hsa046600.84273952
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83151548
62African trypanosomiasis_Homo sapiens_hsa051430.82802638
63Measles_Homo sapiens_hsa051620.81844784
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81172155
65Pancreatic cancer_Homo sapiens_hsa052120.78392007
66Fanconi anemia pathway_Homo sapiens_hsa034600.76213542
67Choline metabolism in cancer_Homo sapiens_hsa052310.74931085
68Toxoplasmosis_Homo sapiens_hsa051450.74795984
69Shigellosis_Homo sapiens_hsa051310.74092040
70Primary immunodeficiency_Homo sapiens_hsa053400.74007347
71Viral carcinogenesis_Homo sapiens_hsa052030.73920594
72Chemical carcinogenesis_Homo sapiens_hsa052040.71126537
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.70647189
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.70533326
75Non-small cell lung cancer_Homo sapiens_hsa052230.69186897
76FoxO signaling pathway_Homo sapiens_hsa040680.69103583
77TNF signaling pathway_Homo sapiens_hsa046680.68760803
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.66948456
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65575199
80Hematopoietic cell lineage_Homo sapiens_hsa046400.64876619
81Ether lipid metabolism_Homo sapiens_hsa005650.64633891
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64432756
83Bladder cancer_Homo sapiens_hsa052190.63704255
84Phototransduction_Homo sapiens_hsa047440.62736439
85Tryptophan metabolism_Homo sapiens_hsa003800.61939314
86Histidine metabolism_Homo sapiens_hsa003400.60934033
87ABC transporters_Homo sapiens_hsa020100.60725623
88Pertussis_Homo sapiens_hsa051330.59899890
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59193171
90Sulfur relay system_Homo sapiens_hsa041220.59085605
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.58985214
92Legionellosis_Homo sapiens_hsa051340.57656249
93Ovarian steroidogenesis_Homo sapiens_hsa049130.57387328
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57318721
95Epstein-Barr virus infection_Homo sapiens_hsa051690.56779356
96Regulation of autophagy_Homo sapiens_hsa041400.56040845
97Renal cell carcinoma_Homo sapiens_hsa052110.55868720
98Notch signaling pathway_Homo sapiens_hsa043300.55821915
99Type II diabetes mellitus_Homo sapiens_hsa049300.54990728
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54296312
101Insulin resistance_Homo sapiens_hsa049310.53220829
102Alcoholism_Homo sapiens_hsa050340.52578742
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52553432
104Small cell lung cancer_Homo sapiens_hsa052220.52174704
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.51248562
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50500838
107Platelet activation_Homo sapiens_hsa046110.49927432
108Thyroid cancer_Homo sapiens_hsa052160.49585649
109Chronic myeloid leukemia_Homo sapiens_hsa052200.48063851
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.48009281
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.47854719
112Pathways in cancer_Homo sapiens_hsa052000.45479234
113Folate biosynthesis_Homo sapiens_hsa007900.44791973
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44144515
115Prostate cancer_Homo sapiens_hsa052150.43782193
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42359626
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42195233
118Proteoglycans in cancer_Homo sapiens_hsa052050.41519522
119Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40644685
120Pentose phosphate pathway_Homo sapiens_hsa000300.39699584
121Chemokine signaling pathway_Homo sapiens_hsa040620.39520701
122p53 signaling pathway_Homo sapiens_hsa041150.39465274
123Rap1 signaling pathway_Homo sapiens_hsa040150.38980758
124HTLV-I infection_Homo sapiens_hsa051660.38904052
125Dorso-ventral axis formation_Homo sapiens_hsa043200.38793056
126PPAR signaling pathway_Homo sapiens_hsa033200.38676148
127Prolactin signaling pathway_Homo sapiens_hsa049170.38592154
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38349021
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37068510
130Phagosome_Homo sapiens_hsa041450.36866229
131Long-term potentiation_Homo sapiens_hsa047200.36716183
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35662820
133VEGF signaling pathway_Homo sapiens_hsa043700.34993647
134Glioma_Homo sapiens_hsa052140.34848537
135Salmonella infection_Homo sapiens_hsa051320.34577955
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33950369
137Colorectal cancer_Homo sapiens_hsa052100.33729769
138Olfactory transduction_Homo sapiens_hsa047400.33492358
139MAPK signaling pathway_Homo sapiens_hsa040100.32385063
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27906655
141Endometrial cancer_Homo sapiens_hsa052130.24514043

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