WDR97

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The function and protein-coding potential of this gene is unknown. The exon combination is based on AB058778.1 for which two possible open reading frames can be predicted (with start codons at nucleotide 26 or 2614). The position of the first ORF stop codon is consistent with a prediction of nonsense-mediated decay. Given the observation of the first ORF and its length, a predicted translation of the second ORF is inconsistent with the translation leaky scanning theory. Therefore, this gene is represented as a non-protein-coding transcript. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.37197149
2fucose catabolic process (GO:0019317)4.87272157
3L-fucose metabolic process (GO:0042354)4.87272157
4L-fucose catabolic process (GO:0042355)4.87272157
5detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.92212684
6DNA deamination (GO:0045006)3.89127619
7response to pheromone (GO:0019236)3.80245195
8cellular ketone body metabolic process (GO:0046950)3.77902597
9axoneme assembly (GO:0035082)3.75576536
10cellular response to ATP (GO:0071318)3.73630341
11regulation of nuclear cell cycle DNA replication (GO:0033262)3.63357797
12tryptophan catabolic process (GO:0006569)3.58554206
13indole-containing compound catabolic process (GO:0042436)3.58554206
14indolalkylamine catabolic process (GO:0046218)3.58554206
15detection of light stimulus involved in sensory perception (GO:0050962)3.54424808
16detection of light stimulus involved in visual perception (GO:0050908)3.54424808
17indolalkylamine metabolic process (GO:0006586)3.47007213
18kynurenine metabolic process (GO:0070189)3.37695769
19ketone body metabolic process (GO:1902224)3.32013363
20glycerophospholipid catabolic process (GO:0046475)3.30090257
21cornea development in camera-type eye (GO:0061303)3.24075004
22auditory receptor cell stereocilium organization (GO:0060088)3.24065168
23piRNA metabolic process (GO:0034587)3.21155577
24water-soluble vitamin biosynthetic process (GO:0042364)3.16056042
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.11064592
26respiratory chain complex IV assembly (GO:0008535)3.08964844
27synaptic transmission, cholinergic (GO:0007271)3.05888208
28regulation of cilium movement (GO:0003352)3.05142585
29tryptophan metabolic process (GO:0006568)3.03524403
30negative regulation of telomere maintenance (GO:0032205)3.02975624
31protein polyglutamylation (GO:0018095)3.01251805
32amine catabolic process (GO:0009310)2.99938346
33cellular biogenic amine catabolic process (GO:0042402)2.99938346
34preassembly of GPI anchor in ER membrane (GO:0016254)2.99819579
35regulation of gene silencing by RNA (GO:0060966)2.98484203
36regulation of posttranscriptional gene silencing (GO:0060147)2.98484203
37regulation of gene silencing by miRNA (GO:0060964)2.98484203
38DNA methylation involved in gamete generation (GO:0043046)2.92805964
39positive regulation of defense response to virus by host (GO:0002230)2.92763235
40S-adenosylmethionine metabolic process (GO:0046500)2.89240181
41epithelial cilium movement (GO:0003351)2.88514524
42nonmotile primary cilium assembly (GO:0035058)2.87812516
43multicellular organism reproduction (GO:0032504)2.84905561
44negative regulation of cytosolic calcium ion concentration (GO:0051481)2.83182545
45regulation of action potential (GO:0098900)2.81055337
46protein localization to cilium (GO:0061512)2.80507018
47reflex (GO:0060004)2.80301794
48purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.80079144
493-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.80079144
50peristalsis (GO:0030432)2.79246241
51regulation of hippo signaling (GO:0035330)2.78372327
52photoreceptor cell development (GO:0042461)2.77144461
53urinary tract smooth muscle contraction (GO:0014848)2.74235226
54startle response (GO:0001964)2.73529995
55cilium movement (GO:0003341)2.71065272
56protein import into peroxisome matrix (GO:0016558)2.70697010
57cilium morphogenesis (GO:0060271)2.69400322
58cilium or flagellum-dependent cell motility (GO:0001539)2.69389251
59fucosylation (GO:0036065)2.68487732
60regulation of rhodopsin mediated signaling pathway (GO:0022400)2.67902636
61sulfation (GO:0051923)2.67789199
62cytochrome complex assembly (GO:0017004)2.67511950
63regulation of memory T cell differentiation (GO:0043380)2.65966008
64neuronal action potential (GO:0019228)2.63169266
65L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.62451338
66rhodopsin mediated signaling pathway (GO:0016056)2.62052105
67mannosylation (GO:0097502)2.60922113
68indole-containing compound metabolic process (GO:0042430)2.58026490
69regulation of triglyceride biosynthetic process (GO:0010866)2.57570973
70photoreceptor cell maintenance (GO:0045494)2.57301424
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.56625953
72positive regulation of triglyceride biosynthetic process (GO:0010867)2.55266221
73platelet dense granule organization (GO:0060155)2.54602637
74cilium organization (GO:0044782)2.53902101
75regulation of microtubule-based movement (GO:0060632)2.53805266
76pseudouridine synthesis (GO:0001522)2.53207484
77phasic smooth muscle contraction (GO:0014821)2.49303537
78peptidyl-histidine modification (GO:0018202)2.48950286
79G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47370228
80sperm motility (GO:0030317)2.46074027
81methionine biosynthetic process (GO:0009086)2.45759469
82positive regulation of oligodendrocyte differentiation (GO:0048714)2.44877189
83cilium assembly (GO:0042384)2.44792252
84eye photoreceptor cell development (GO:0042462)2.44546190
85retinal cone cell development (GO:0046549)2.43508281
86mitochondrial respiratory chain complex I assembly (GO:0032981)2.42684623
87NADH dehydrogenase complex assembly (GO:0010257)2.42684623
88mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.42684623
89transepithelial transport (GO:0070633)2.41804885
90purinergic nucleotide receptor signaling pathway (GO:0035590)2.41258281
91tRNA modification (GO:0006400)2.40668542
92behavioral response to ethanol (GO:0048149)2.40185498
93negative regulation of mast cell activation (GO:0033004)2.39532288
94protein complex biogenesis (GO:0070271)2.38766183
95protein-cofactor linkage (GO:0018065)2.38420575
96L-methionine salvage (GO:0071267)2.35615845
97L-methionine biosynthetic process (GO:0071265)2.35615845
98amino acid salvage (GO:0043102)2.35615845
99basic amino acid transport (GO:0015802)2.35292388
100inositol phosphate catabolic process (GO:0071545)2.34985833

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.18617600
2VDR_22108803_ChIP-Seq_LS180_Human3.21023334
3GBX2_23144817_ChIP-Seq_PC3_Human2.39971314
4NOTCH1_21737748_ChIP-Seq_TLL_Human2.20826812
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19063624
6EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.05914980
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98651817
8ER_23166858_ChIP-Seq_MCF-7_Human1.96355857
9ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96025889
10IGF1R_20145208_ChIP-Seq_DFB_Human1.92458644
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90451456
12EZH2_22144423_ChIP-Seq_EOC_Human1.87756320
13CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85156069
14CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83250059
15EWS_26573619_Chip-Seq_HEK293_Human1.80182437
16REST_21632747_ChIP-Seq_MESCs_Mouse1.80000282
17TAF15_26573619_Chip-Seq_HEK293_Human1.79194866
18TP53_22573176_ChIP-Seq_HFKS_Human1.77569544
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.74904928
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74904718
21ERA_21632823_ChIP-Seq_H3396_Human1.70076036
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.66730393
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63502999
24DROSHA_22980978_ChIP-Seq_HELA_Human1.61986671
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52000894
26CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48617126
27MYC_19829295_ChIP-Seq_ESCs_Human1.48011886
28FUS_26573619_Chip-Seq_HEK293_Human1.47689549
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.44841822
30BCAT_22108803_ChIP-Seq_LS180_Human1.41791971
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40425656
32GATA3_21878914_ChIP-Seq_MCF-7_Human1.40364107
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.39787637
34NCOR_22424771_ChIP-Seq_293T_Human1.39385016
35HOXB7_26014856_ChIP-Seq_BT474_Human1.38791010
36EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.38032409
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37489488
38FOXA1_25329375_ChIP-Seq_VCAP_Human1.36228356
39FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36228356
40P300_19829295_ChIP-Seq_ESCs_Human1.35228640
41IRF1_19129219_ChIP-ChIP_H3396_Human1.34578532
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.34481007
43ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33024505
44STAT3_23295773_ChIP-Seq_U87_Human1.30465866
45TCF4_23295773_ChIP-Seq_U87_Human1.30251892
46TAF2_19829295_ChIP-Seq_ESCs_Human1.28539060
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27965358
48CBP_20019798_ChIP-Seq_JUKART_Human1.27965358
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.27645417
50OCT4_20526341_ChIP-Seq_ESCs_Human1.26954355
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26670057
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25183299
53P53_21459846_ChIP-Seq_SAOS-2_Human1.23755319
54E2F1_20622854_ChIP-Seq_HELA_Human1.23175459
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21724443
56EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.21605431
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20852076
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20723244
59AR_20517297_ChIP-Seq_VCAP_Human1.18079280
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16648912
61MYC_18940864_ChIP-ChIP_HL60_Human1.16045888
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.15738682
63EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.15670474
64NANOG_20526341_ChIP-Seq_ESCs_Human1.15310173
65NANOG_19829295_ChIP-Seq_ESCs_Human1.15112161
66SOX2_19829295_ChIP-Seq_ESCs_Human1.15112161
67AR_25329375_ChIP-Seq_VCAP_Human1.13191596
68RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12270299
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12089858
70TDRD3_21172665_ChIP-Seq_MCF-7_Human1.11572235
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11010375
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10955194
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10318853
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10318853
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.06621285
76BCL6_27268052_Chip-Seq_Bcells_Human1.06235411
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03978367
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03487510
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02975818
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02874549
81RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02364414
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02257882
83PHF8_20622854_ChIP-Seq_HELA_Human1.02251608
84RAC3_21632823_ChIP-Seq_H3396_Human1.02115221
85FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02078745
86TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01512897
87CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01005289
88SMAD4_21741376_ChIP-Seq_EPCs_Human1.00989802
89GATA3_26560356_Chip-Seq_TH2_Human1.00496522
90RUNX2_22187159_ChIP-Seq_PCA_Human1.00449044
91VDR_23849224_ChIP-Seq_CD4+_Human0.99674828
92SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99571029
93TCF4_22108803_ChIP-Seq_LS180_Human0.99305698
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98012651
95CBX2_27304074_Chip-Seq_ESCs_Mouse0.97691778
96SMAD4_21799915_ChIP-Seq_A2780_Human0.96834673
97PIAS1_25552417_ChIP-Seq_VCAP_Human0.96495302
98FOXH1_21741376_ChIP-Seq_ESCs_Human0.95164240
99GABP_17652178_ChIP-ChIP_JURKAT_Human0.91598917
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91376252

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity3.15081269
2MP0003195_calcinosis3.11453067
3MP0005551_abnormal_eye_electrophysiolog2.72431017
4MP0001968_abnormal_touch/_nociception2.72129803
5MP0004043_abnormal_pH_regulation2.70749582
6MP0002102_abnormal_ear_morphology2.62608889
7MP0002638_abnormal_pupillary_reflex2.42480421
8MP0004147_increased_porphyrin_level2.39232485
9MP0008875_abnormal_xenobiotic_pharmacok2.30655901
10MP0002876_abnormal_thyroid_physiology2.29362014
11MP0005174_abnormal_tail_pigmentation2.28454153
12MP0005646_abnormal_pituitary_gland2.06354499
13MP0008872_abnormal_physiological_respon2.03598548
14MP0002736_abnormal_nociception_after1.96991507
15MP0005645_abnormal_hypothalamus_physiol1.94843194
16MP0009745_abnormal_behavioral_response1.93653136
17MP0003646_muscle_fatigue1.92380356
18MP0008877_abnormal_DNA_methylation1.91780889
19MP0003136_yellow_coat_color1.90083450
20MP0000569_abnormal_digit_pigmentation1.84464937
21MP0009046_muscle_twitch1.83381551
22MP0001188_hyperpigmentation1.77082057
23MP0003787_abnormal_imprinting1.76172885
24MP0002837_dystrophic_cardiac_calcinosis1.71267985
25MP0005171_absent_coat_pigmentation1.67990516
26MP0002272_abnormal_nervous_system1.67252762
27MP0001501_abnormal_sleep_pattern1.67020520
28MP0003880_abnormal_central_pattern1.66956373
29MP0004885_abnormal_endolymph1.63997081
30MP0005423_abnormal_somatic_nervous1.63000920
31MP0004142_abnormal_muscle_tone1.59017915
32MP0005253_abnormal_eye_physiology1.58392057
33MP0000427_abnormal_hair_cycle1.55665823
34MP0006072_abnormal_retinal_apoptosis1.54056383
35MP0005377_hearing/vestibular/ear_phenot1.53123297
36MP0003878_abnormal_ear_physiology1.53123297
37MP0002735_abnormal_chemical_nociception1.51585693
38MP0001486_abnormal_startle_reflex1.49912307
39MP0001502_abnormal_circadian_rhythm1.44792567
40MP0003011_delayed_dark_adaptation1.44628086
41MP0004133_heterotaxia1.39996848
42MP0002064_seizures1.36872334
43MP0005410_abnormal_fertilization1.33608823
44MP0002572_abnormal_emotion/affect_behav1.26987533
45MP0006276_abnormal_autonomic_nervous1.24417825
46MP0002928_abnormal_bile_duct1.24044604
47MP0001970_abnormal_pain_threshold1.23914168
48MP0000383_abnormal_hair_follicle1.22848669
49MP0002254_reproductive_system_inflammat1.21439324
50MP0005167_abnormal_blood-brain_barrier1.18067518
51MP0001485_abnormal_pinna_reflex1.17918217
52MP0010386_abnormal_urinary_bladder1.15929037
53MP0002557_abnormal_social/conspecific_i1.15478879
54MP0005386_behavior/neurological_phenoty1.15231826
55MP0004924_abnormal_behavior1.15231826
56MP0001905_abnormal_dopamine_level1.11543508
57MP0002160_abnormal_reproductive_system1.11186044
58MP0005332_abnormal_amino_acid1.06269931
59MP0004742_abnormal_vestibular_system1.05420174
60MP0000015_abnormal_ear_pigmentation1.04936337
61MP0002063_abnormal_learning/memory/cond1.03835589
62MP0002138_abnormal_hepatobiliary_system1.02004222
63MP0002163_abnormal_gland_morphology1.01857314
64MP0008995_early_reproductive_senescence1.01787296
65MP0003635_abnormal_synaptic_transmissio1.01427703
66MP0008775_abnormal_heart_ventricle1.01315106
67MP0010329_abnormal_lipoprotein_level1.01271380
68MP0002653_abnormal_ependyma_morphology1.01237318
69MP0000631_abnormal_neuroendocrine_gland1.01192114
70MP0002067_abnormal_sensory_capabilities0.99896435
71MP0006292_abnormal_olfactory_placode0.99428880
72MP0002693_abnormal_pancreas_physiology0.99407246
73MP0002733_abnormal_thermal_nociception0.99248993
74MP0000538_abnormal_urinary_bladder0.97396740
75MP0001984_abnormal_olfaction0.97115882
76MP0005389_reproductive_system_phenotype0.96388088
77MP0002229_neurodegeneration0.95459075
78MP0001756_abnormal_urination0.94291434
79MP0001765_abnormal_ion_homeostasis0.94050363
80MP0001764_abnormal_homeostasis0.93981957
81MP0004381_abnormal_hair_follicle0.93059629
82MP0005084_abnormal_gallbladder_morpholo0.92014784
83MP0003283_abnormal_digestive_organ0.90963408
84MP0002909_abnormal_adrenal_gland0.89051592
85MP0000013_abnormal_adipose_tissue0.88467122
86MP0001944_abnormal_pancreas_morphology0.88224637
87MP0005365_abnormal_bile_salt0.86521387
88MP0005448_abnormal_energy_balance0.86319518
89MP0001919_abnormal_reproductive_system0.86039618
90MP0004019_abnormal_vitamin_homeostasis0.84086698
91MP0003879_abnormal_hair_cell0.83968668
92MP0000026_abnormal_inner_ear0.83752872
93MP0003698_abnormal_male_reproductive0.83204550
94MP0005195_abnormal_posterior_eye0.82573791
95MP0005379_endocrine/exocrine_gland_phen0.81929419
96MP0005220_abnormal_exocrine_pancreas0.80397117
97MP0001963_abnormal_hearing_physiology0.79500221
98MP0000685_abnormal_immune_system0.79350070
99MP0000230_abnormal_systemic_arterial0.78093186
100MP0003137_abnormal_impulse_conducting0.75515822

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.12874253
2Pancreatic cysts (HP:0001737)4.31337382
3Molar tooth sign on MRI (HP:0002419)4.14077146
4Abnormality of midbrain morphology (HP:0002418)4.14077146
5Nephronophthisis (HP:0000090)3.94240588
6Attenuation of retinal blood vessels (HP:0007843)3.71007490
7Pancreatic fibrosis (HP:0100732)3.67215174
8True hermaphroditism (HP:0010459)3.65496913
9Abnormality of the renal medulla (HP:0100957)3.45227361
10Abnormality of the renal cortex (HP:0011035)3.23205929
11Abnormal drinking behavior (HP:0030082)3.11534612
12Polydipsia (HP:0001959)3.11534612
13Pendular nystagmus (HP:0012043)3.08811908
14Chronic hepatic failure (HP:0100626)3.08471859
15Tubular atrophy (HP:0000092)2.97090126
16Type II lissencephaly (HP:0007260)2.91234442
17Cystic liver disease (HP:0006706)2.90512209
18Hyperventilation (HP:0002883)2.85403804
19Decreased electroretinogram (ERG) amplitude (HP:0000654)2.79256554
20Abnormal rod and cone electroretinograms (HP:0008323)2.77069878
21Large for gestational age (HP:0001520)2.74354952
22Medial flaring of the eyebrow (HP:0010747)2.72886377
23Bony spicule pigmentary retinopathy (HP:0007737)2.67636190
24Abolished electroretinogram (ERG) (HP:0000550)2.59906157
25Chorioretinal atrophy (HP:0000533)2.55889330
26Abnormal biliary tract physiology (HP:0012439)2.48813915
27Bile duct proliferation (HP:0001408)2.48813915
28Polyuria (HP:0000103)2.44557304
29Ketoacidosis (HP:0001993)2.43456609
30Decreased circulating renin level (HP:0003351)2.43074475
31Inability to walk (HP:0002540)2.40444176
32Progressive inability to walk (HP:0002505)2.35109764
33Decreased central vision (HP:0007663)2.33743824
34Congenital hepatic fibrosis (HP:0002612)2.32745660
35Rib fusion (HP:0000902)2.32392459
36Hyperalaninemia (HP:0003348)2.31474305
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.31474305
38Abnormality of alanine metabolism (HP:0010916)2.31474305
39Stomatitis (HP:0010280)2.24739440
40Genetic anticipation (HP:0003743)2.24508250
41Hemiparesis (HP:0001269)2.24352745
42Ketosis (HP:0001946)2.22842497
43Clumsiness (HP:0002312)2.22736929
44Patellar aplasia (HP:0006443)2.20714177
45Renal cortical cysts (HP:0000803)2.19759109
46Broad-based gait (HP:0002136)2.18696409
47Stomach cancer (HP:0012126)2.15964633
48Aplasia/Hypoplasia of the patella (HP:0006498)2.14471024
49Severe muscular hypotonia (HP:0006829)2.13970530
50Absent speech (HP:0001344)2.13242904
51Sclerocornea (HP:0000647)2.12773630
52Febrile seizures (HP:0002373)2.12163516
53Gait imbalance (HP:0002141)2.09082147
54Cerebellar dysplasia (HP:0007033)2.07785283
55Male pseudohermaphroditism (HP:0000037)2.07142661
56Lissencephaly (HP:0001339)2.04715230
57Furrowed tongue (HP:0000221)2.04327548
58Progressive microcephaly (HP:0000253)2.03703486
593-Methylglutaconic aciduria (HP:0003535)2.02036215
60Congenital primary aphakia (HP:0007707)2.00798779
61Keratoconus (HP:0000563)2.00733110
62Increased corneal curvature (HP:0100692)2.00733110
63Widely spaced teeth (HP:0000687)2.00600248
64Gaze-evoked nystagmus (HP:0000640)1.99754632
65Abnormality of the pons (HP:0007361)1.97069322
66Progressive cerebellar ataxia (HP:0002073)1.95606464
67Abnormal albumin level (HP:0012116)1.94893497
68Hypoalbuminemia (HP:0003073)1.94893497
69Nephrogenic diabetes insipidus (HP:0009806)1.94619944
70Concave nail (HP:0001598)1.94222198
71Anencephaly (HP:0002323)1.94174626
72Abnormal urine output (HP:0012590)1.93935620
73Protruding tongue (HP:0010808)1.92072861
74Thyroiditis (HP:0100646)1.90022012
75Dynein arm defect of respiratory motile cilia (HP:0012255)1.89925981
76Absent/shortened dynein arms (HP:0200106)1.89925981
77Congenital sensorineural hearing impairment (HP:0008527)1.89373859
78Abnormal respiratory motile cilium morphology (HP:0005938)1.88344093
79Abnormal respiratory epithelium morphology (HP:0012253)1.88344093
80Hypoplasia of the pons (HP:0012110)1.88035426
81Testicular atrophy (HP:0000029)1.86370819
82Tachypnea (HP:0002789)1.84726277
83Pachygyria (HP:0001302)1.82829180
84Occipital encephalocele (HP:0002085)1.78960605
85Aplasia/Hypoplasia of the tongue (HP:0010295)1.77695421
86Retinitis pigmentosa (HP:0000510)1.75540930
87Severe visual impairment (HP:0001141)1.74837857
88Absent rod-and cone-mediated responses on ERG (HP:0007688)1.71280067
89Short chin (HP:0000331)1.71025656
90Congenital, generalized hypertrichosis (HP:0004540)1.69803047
91Methylmalonic aciduria (HP:0012120)1.68642111
92Abnormality of renal excretion (HP:0011036)1.68554164
93Aplasia/Hypoplasia of the spleen (HP:0010451)1.68036839
94Postaxial foot polydactyly (HP:0001830)1.67544543
95Tubulointerstitial nephritis (HP:0001970)1.67367142
96Bulbous nose (HP:0000414)1.65677869
97Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.64826247
98Amelogenesis imperfecta (HP:0000705)1.64484112
99Type II diabetes mellitus (HP:0005978)1.64036719
100IgG deficiency (HP:0004315)1.63610171

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.86796038
2BMPR1B3.53702277
3ADRBK23.50672044
4ACVR1B3.34584382
5WNK43.14222013
6MAP4K23.12886178
7MAPK152.87709589
8TAOK32.72757220
9TLK12.71949747
10ZAK2.70322726
11GRK12.57576779
12PINK12.07905033
13WNK31.94841750
14DAPK21.93175298
15AKT31.92488672
16MAPK131.91975276
17CASK1.64898427
18MAPKAPK31.62016474
19MUSK1.57387251
20INSRR1.47741256
21MAP2K61.39845738
22NUAK11.38699515
23TNK21.38671001
24OXSR11.21598202
25ADRBK11.18731357
26MAP3K41.14283003
27PHKG11.08662603
28PHKG21.08662603
29PAK31.07149582
30NME11.02480683
31IKBKB1.01598909
32STK391.01249710
33PRKCI1.00333544
34TGFBR10.96896862
35CHUK0.93719498
36TRIM280.87472390
37TXK0.86003283
38MKNK20.85275054
39PRKCE0.84666158
40PTK2B0.84100146
41FGFR20.83218239
42CAMKK20.82138693
43PRKD20.78363321
44NTRK30.77699774
45PRKCG0.76767128
46STK110.75806581
47IRAK40.70708513
48TNIK0.69301962
49SIK20.67471620
50DYRK20.64904927
51STK38L0.64601440
52SGK20.63849516
53PLK20.63666376
54MARK10.63355025
55GRK60.62865301
56NLK0.61484642
57MAP2K20.60076948
58RPS6KA50.59509963
59MAPKAPK50.59165523
60MARK30.58335435
61PRKCQ0.57515834
62NTRK20.57255969
63MAP3K70.55138633
64FER0.53754846
65PRKAA10.53525171
66HIPK20.53131305
67PRKAA20.52768876
68TEC0.52179565
69PRKCH0.52118884
70SGK4940.51601398
71SGK2230.51601398
72MAP4K10.51422703
73ITK0.49406416
74CAMK10.48528789
75KIT0.48386365
76CAMKK10.46766698
77BCKDK0.45804422
78CSNK1D0.42886085
79PRKACA0.42454329
80TIE10.41733680
81PRKCZ0.40445003
82PRKD30.39947304
83MAP2K70.39157495
84ERBB30.37946085
85PKN10.37627051
86CSNK1A10.36745529
87MAP2K10.36141395
88RPS6KA60.35811236
89IKBKE0.34767077
90CAMK2A0.34132417
91SYK0.34087493
92CSNK1G10.30963336
93PIK3CA0.30510333
94CAMK1D0.30443020
95ERBB20.29818822
96PRKCA0.28410621
97CAMK40.27675246
98WNK10.27608691
99CSNK1G20.27521031
100EPHA40.26887658

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.16550656
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.12034426
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.93730502
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.93125124
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.53590936
6Linoleic acid metabolism_Homo sapiens_hsa005912.44831438
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.37957286
8Nitrogen metabolism_Homo sapiens_hsa009102.37942969
9Nicotine addiction_Homo sapiens_hsa050332.28812272
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.24423587
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.20644856
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.16168090
13Butanoate metabolism_Homo sapiens_hsa006502.04745345
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04428151
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90922984
16Selenocompound metabolism_Homo sapiens_hsa004501.88047249
17ABC transporters_Homo sapiens_hsa020101.76109488
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.75888110
19Basal transcription factors_Homo sapiens_hsa030221.65522822
20Ether lipid metabolism_Homo sapiens_hsa005651.60264549
21Taste transduction_Homo sapiens_hsa047421.58974598
22Tryptophan metabolism_Homo sapiens_hsa003801.50598062
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.45938573
24Fanconi anemia pathway_Homo sapiens_hsa034601.41744009
25Homologous recombination_Homo sapiens_hsa034401.33186298
26Insulin secretion_Homo sapiens_hsa049111.30793939
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.29406197
28Morphine addiction_Homo sapiens_hsa050321.27229277
29RNA polymerase_Homo sapiens_hsa030201.25710346
30Regulation of autophagy_Homo sapiens_hsa041401.25050067
31Primary immunodeficiency_Homo sapiens_hsa053401.23756008
32Caffeine metabolism_Homo sapiens_hsa002321.23457506
33Sulfur relay system_Homo sapiens_hsa041221.15711627
34Olfactory transduction_Homo sapiens_hsa047401.15630105
35Peroxisome_Homo sapiens_hsa041461.09303693
36Dorso-ventral axis formation_Homo sapiens_hsa043201.09081228
37Chemical carcinogenesis_Homo sapiens_hsa052041.05049477
38Oxidative phosphorylation_Homo sapiens_hsa001901.04621874
39Glutamatergic synapse_Homo sapiens_hsa047241.02729091
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02413097
41Ovarian steroidogenesis_Homo sapiens_hsa049131.01470667
42Circadian entrainment_Homo sapiens_hsa047131.00541777
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98799238
44Serotonergic synapse_Homo sapiens_hsa047260.95636991
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95304360
46GABAergic synapse_Homo sapiens_hsa047270.91972915
47Collecting duct acid secretion_Homo sapiens_hsa049660.89110440
48One carbon pool by folate_Homo sapiens_hsa006700.88635881
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.86718890
50Arachidonic acid metabolism_Homo sapiens_hsa005900.86693310
51Glycerolipid metabolism_Homo sapiens_hsa005610.86574298
52Asthma_Homo sapiens_hsa053100.84568499
53Calcium signaling pathway_Homo sapiens_hsa040200.82150437
54Sphingolipid metabolism_Homo sapiens_hsa006000.80216826
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78808470
56Circadian rhythm_Homo sapiens_hsa047100.78376527
57Salivary secretion_Homo sapiens_hsa049700.77341927
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74194690
59Retinol metabolism_Homo sapiens_hsa008300.73815129
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.73117035
61Fatty acid biosynthesis_Homo sapiens_hsa000610.73084693
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71580933
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70468007
64RNA degradation_Homo sapiens_hsa030180.67784825
65Type I diabetes mellitus_Homo sapiens_hsa049400.67226047
66Fat digestion and absorption_Homo sapiens_hsa049750.62518737
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61789729
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60488225
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59003141
70Dopaminergic synapse_Homo sapiens_hsa047280.57901874
71Lysine degradation_Homo sapiens_hsa003100.55170628
72Amphetamine addiction_Homo sapiens_hsa050310.53822671
73Vitamin digestion and absorption_Homo sapiens_hsa049770.53664375
74Propanoate metabolism_Homo sapiens_hsa006400.51500497
75Graft-versus-host disease_Homo sapiens_hsa053320.51015660
76Histidine metabolism_Homo sapiens_hsa003400.49951252
77Cocaine addiction_Homo sapiens_hsa050300.49443091
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.49322298
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47490018
80Mineral absorption_Homo sapiens_hsa049780.47377724
81Metabolic pathways_Homo sapiens_hsa011000.46770161
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44605583
83Parkinsons disease_Homo sapiens_hsa050120.43217830
84Protein export_Homo sapiens_hsa030600.42476978
85beta-Alanine metabolism_Homo sapiens_hsa004100.42243485
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42221471
87Sulfur metabolism_Homo sapiens_hsa009200.41744989
88Vitamin B6 metabolism_Homo sapiens_hsa007500.41018165
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40459402
90cAMP signaling pathway_Homo sapiens_hsa040240.40195053
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39898596
92Purine metabolism_Homo sapiens_hsa002300.39833538
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39288891
94Cholinergic synapse_Homo sapiens_hsa047250.38222028
95Autoimmune thyroid disease_Homo sapiens_hsa053200.38189406
96Allograft rejection_Homo sapiens_hsa053300.37598390
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.37541853
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36150296
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35702719
100Long-term depression_Homo sapiens_hsa047300.35066067

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