WDSUB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of chemical stimulus (GO:0007606)7.59689330
2piRNA metabolic process (GO:0034587)6.05558892
3auditory receptor cell differentiation (GO:0042491)5.86780569
4protein localization to cilium (GO:0061512)5.80438973
5signal peptide processing (GO:0006465)5.18689691
6synapsis (GO:0007129)5.05309650
7regulation of female gonad development (GO:2000194)4.99231801
8intraciliary transport (GO:0042073)4.94472760
9negative regulation of DNA-dependent DNA replication (GO:2000104)4.92290502
10protein insertion into membrane (GO:0051205)4.59939511
11regulation of cilium movement (GO:0003352)4.58580375
12regulation of meiosis I (GO:0060631)4.27670329
13inositol phosphate dephosphorylation (GO:0046855)4.27482086
14phosphorylated carbohydrate dephosphorylation (GO:0046838)4.27482086
15DNA methylation involved in gamete generation (GO:0043046)4.24826224
16male meiosis I (GO:0007141)4.11489768
17protein heterotetramerization (GO:0051290)4.10050317
18inositol phosphate catabolic process (GO:0071545)4.08829509
19inner ear receptor cell differentiation (GO:0060113)4.04847523
20mucosal immune response (GO:0002385)3.93675057
21cilium morphogenesis (GO:0060271)3.86289212
22organ or tissue specific immune response (GO:0002251)3.85427913
23regulation of DNA endoreduplication (GO:0032875)3.83110852
24pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.81083259
25axoneme assembly (GO:0035082)3.77501180
26innate immune response in mucosa (GO:0002227)3.75865990
27axonemal dynein complex assembly (GO:0070286)3.75271857
28regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.74493415
29protein polyglutamylation (GO:0018095)3.67424748
30base-excision repair, AP site formation (GO:0006285)3.64427025
31chaperone mediated protein folding requiring cofactor (GO:0051085)3.58719738
32positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)3.50605075
33antibacterial humoral response (GO:0019731)3.50128458
34energy homeostasis (GO:0097009)3.49248673
35regulation of acyl-CoA biosynthetic process (GO:0050812)3.48534356
36nucleoside diphosphate catabolic process (GO:0009134)3.48103954
37one-carbon compound transport (GO:0019755)3.46180925
38C-terminal protein lipidation (GO:0006501)3.45978438
39oligosaccharide catabolic process (GO:0009313)3.44863402
40respiratory chain complex IV assembly (GO:0008535)3.40477326
41positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.39373709
42magnesium ion transport (GO:0015693)3.37132258
43positive regulation of vesicle fusion (GO:0031340)3.36662657
44positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.35084020
45DNA ligation (GO:0006266)3.32455802
46GTP biosynthetic process (GO:0006183)3.30900572
47polyol catabolic process (GO:0046174)3.28826603
48positive regulation of cell cycle G1/S phase transition (GO:1902808)3.28272455
49guanosine-containing compound biosynthetic process (GO:1901070)3.28159487
50immunoglobulin mediated immune response (GO:0016064)3.27653928
51meiosis I (GO:0007127)3.27450826
52response to caffeine (GO:0031000)3.27376722
53nucleotide transmembrane transport (GO:1901679)3.27017151
54fucose metabolic process (GO:0006004)3.26830704
55GPI anchor biosynthetic process (GO:0006506)3.25936348
56negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.24838902
57cyclooxygenase pathway (GO:0019371)3.22998028
58C-terminal protein amino acid modification (GO:0018410)3.21946821
59aldehyde catabolic process (GO:0046185)3.21661140
60male meiosis (GO:0007140)3.18845610
61pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.18607042
62protein K11-linked ubiquitination (GO:0070979)3.18312609
63water-soluble vitamin biosynthetic process (GO:0042364)3.17336889
64histone H2A ubiquitination (GO:0033522)3.17030990
65antimicrobial humoral response (GO:0019730)3.16527084
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.16050778
67CTP biosynthetic process (GO:0006241)3.14998326
68CTP metabolic process (GO:0046036)3.14998326
69response to hydroperoxide (GO:0033194)3.13840481
70regulation of metalloenzyme activity (GO:0048552)3.13098493
71pyrimidine nucleotide catabolic process (GO:0006244)3.09880196
72negative regulation of granulocyte differentiation (GO:0030853)3.09398236
73regulation of coenzyme metabolic process (GO:0051196)3.09079465
74regulation of cofactor metabolic process (GO:0051193)3.09079465
75positive regulation of histone H3-K4 methylation (GO:0051571)3.04012865
76rRNA catabolic process (GO:0016075)3.02453075
77amyloid precursor protein catabolic process (GO:0042987)3.01909171
78chromosome organization involved in meiosis (GO:0070192)3.01266908
79facial nerve structural organization (GO:0021612)3.00758477
80deoxyribonucleotide catabolic process (GO:0009264)3.00458457
81negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.99085539
82regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.98831257
83sister chromatid cohesion (GO:0007062)2.98335963
84deoxyribose phosphate catabolic process (GO:0046386)2.96998416
85mechanoreceptor differentiation (GO:0042490)2.95762638
86cytochrome complex assembly (GO:0017004)2.92933774
87epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.90729256
88proteasome assembly (GO:0043248)2.90001654
89detection of calcium ion (GO:0005513)2.89732251
90mitochondrial respiratory chain complex assembly (GO:0033108)2.89668170
91regulation of B cell apoptotic process (GO:0002902)2.89071136
92short-chain fatty acid metabolic process (GO:0046459)2.88118402
93DNA catabolic process, exonucleolytic (GO:0000738)2.87746336
94respiratory electron transport chain (GO:0022904)2.87437199
95G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.87282191
96cellular ketone body metabolic process (GO:0046950)2.86477381
97electron transport chain (GO:0022900)2.84300091
98regulation of sulfur metabolic process (GO:0042762)2.84152588
99histone H2B ubiquitination (GO:0033523)2.83661058
100ketone body metabolic process (GO:1902224)2.82335283
101regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.82176803
102positive regulation of insulin receptor signaling pathway (GO:0046628)2.81956585
103mitochondrial calcium ion homeostasis (GO:0051560)2.81212321
104autophagic vacuole fusion (GO:0000046)2.81133477
105DNA double-strand break processing (GO:0000729)2.79459199
106negative regulation of telomere maintenance (GO:0032205)2.79384928
107intra-Golgi vesicle-mediated transport (GO:0006891)2.78712405
108hair cell differentiation (GO:0035315)2.78675334
109GPI anchor metabolic process (GO:0006505)2.78133786
110organelle membrane fusion (GO:0090174)2.77596220
111mitochondrial respiratory chain complex I assembly (GO:0032981)2.74097682
112NADH dehydrogenase complex assembly (GO:0010257)2.74097682
113mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.74097682
114ether lipid metabolic process (GO:0046485)2.73477841
115B cell mediated immunity (GO:0019724)2.73205255
116energy coupled proton transport, down electrochemical gradient (GO:0015985)2.73169011
117ATP synthesis coupled proton transport (GO:0015986)2.73169011
118pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.73061757
119UTP biosynthetic process (GO:0006228)2.72268682
120positive regulation of mitotic sister chromatid separation (GO:1901970)2.72037985
121positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.72037985
122positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.72037985
123membrane protein ectodomain proteolysis (GO:0006509)2.71879070
124positive regulation of response to oxidative stress (GO:1902884)2.71046332
125positive regulation of cellular response to oxidative stress (GO:1900409)2.71046332
126meiotic nuclear division (GO:0007126)2.70172362
127somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.69452433
128isotype switching (GO:0045190)2.69452433
129somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.69452433
130regulation of oxidative stress-induced neuron death (GO:1903203)2.68842849
131regulation of nuclear cell cycle DNA replication (GO:0033262)2.68058229
132maturation of 5.8S rRNA (GO:0000460)2.67608147
133single strand break repair (GO:0000012)2.67466535
134cullin deneddylation (GO:0010388)2.67103928
135glandular epithelial cell differentiation (GO:0002067)2.66234137
136negative regulation of JUN kinase activity (GO:0043508)2.64306467
137mannosylation (GO:0097502)2.63453319
138negative regulation of membrane potential (GO:0045837)2.63448755
139regulation of mitochondrial translation (GO:0070129)2.61190516
140activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.61039987
141glycoside metabolic process (GO:0016137)2.60992423
142regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.60623752
143heart contraction (GO:0060047)2.60454959
144heart process (GO:0003015)2.60454959
145branched-chain amino acid catabolic process (GO:0009083)2.60436945
146regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.59241884
147pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.57705905
148melanosome transport (GO:0032402)2.54871485
149RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.54513573
150tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.54513573
151protein complex biogenesis (GO:0070271)2.54457817
152protein neddylation (GO:0045116)2.54397133
153regulation of glucokinase activity (GO:0033131)2.54284282
154regulation of hexokinase activity (GO:1903299)2.54284282
155prostanoid biosynthetic process (GO:0046457)2.53869212
156prostaglandin biosynthetic process (GO:0001516)2.53869212
157pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.53605466
158photoreceptor cell maintenance (GO:0045494)2.52648732
159protein deneddylation (GO:0000338)2.52296778
160UTP metabolic process (GO:0046051)2.51860303
161protein-cofactor linkage (GO:0018065)2.51589786
162nucleoside diphosphate phosphorylation (GO:0006165)2.46313529
163pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.45936820
164nonmotile primary cilium assembly (GO:0035058)2.45231832
165bundle of His cell to Purkinje myocyte communication (GO:0086069)2.45034697
166peptidyl-histidine modification (GO:0018202)2.42913160
167fucose catabolic process (GO:0019317)2.41140159
168L-fucose metabolic process (GO:0042354)2.41140159
169L-fucose catabolic process (GO:0042355)2.41140159
170mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.39610245
171pigment granule transport (GO:0051904)2.39376398
172negative regulation of cAMP-mediated signaling (GO:0043951)2.38871860
173cellular response to leptin stimulus (GO:0044320)2.38372698
174preassembly of GPI anchor in ER membrane (GO:0016254)2.36891824
175regulation of microtubule-based movement (GO:0060632)2.35977183
176fibroblast migration (GO:0010761)2.32981651
177mesenchymal cell differentiation involved in kidney development (GO:0072161)2.32926892
178mesenchymal cell differentiation involved in renal system development (GO:2001012)2.32926892
179cilium movement (GO:0003341)2.32745092
180deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.32362823
181establishment of melanosome localization (GO:0032401)2.32239817
182axon ensheathment in central nervous system (GO:0032291)2.31252355
183sensory perception of smell (GO:0007608)13.9345293

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.86246600
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.58741826
3GATA1_22025678_ChIP-Seq_K562_Human4.53677255
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.30492960
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.10602596
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.08494081
7ZNF274_21170338_ChIP-Seq_K562_Hela3.01391602
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.92773534
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.79774275
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.70479736
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.66163289
12PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.52859716
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51489283
14CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.41794730
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.40746044
16IGF1R_20145208_ChIP-Seq_DFB_Human2.20803130
17DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.16644127
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.14333484
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.13864353
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.13600209
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.04423081
22SCL_19346495_ChIP-Seq_HPC-7_Human2.03478790
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.02406932
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.00539247
25FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.98435615
26FUS_26573619_Chip-Seq_HEK293_Human1.96611911
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.95557404
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87197584
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.86285020
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.85952925
31* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85339324
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.84637473
33IRF1_19129219_ChIP-ChIP_H3396_Human1.79363725
34VDR_23849224_ChIP-Seq_CD4+_Human1.78527774
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.76511341
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73680672
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73095270
38EWS_26573619_Chip-Seq_HEK293_Human1.71891085
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71798808
40ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.69801462
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69263926
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.61422652
43DCP1A_22483619_ChIP-Seq_HELA_Human1.60872999
44* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59080047
45* P300_19829295_ChIP-Seq_ESCs_Human1.57194601
46VDR_22108803_ChIP-Seq_LS180_Human1.56562651
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55552436
48ER_23166858_ChIP-Seq_MCF-7_Human1.53804560
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.52547488
50* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51334149
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.50913742
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50364959
53SOX2_20726797_ChIP-Seq_SW620_Human1.43412398
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40354175
55STAT1_20625510_ChIP-Seq_HELA_Human1.39938928
56RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.37876586
57* GATA3_26560356_Chip-Seq_TH2_Human1.36783896
58ELK1_19687146_ChIP-ChIP_HELA_Human1.35343122
59LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34908958
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.34473962
61MYC_18940864_ChIP-ChIP_HL60_Human1.34390937
62E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33742593
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33350324
64* GBX2_23144817_ChIP-Seq_PC3_Human1.32837976
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.32442167
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30401965
67ESR1_20079471_ChIP-ChIP_T-47D_Human1.30333467
68HTT_18923047_ChIP-ChIP_STHdh_Human1.29627398
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28877046
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.28877046
71TP53_22573176_ChIP-Seq_HFKS_Human1.27894344
72FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27392431
73MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.27016998
74CDX2_22108803_ChIP-Seq_LS180_Human1.26425629
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23441412
76FOXP3_21729870_ChIP-Seq_TREG_Human1.20231348
77ZNF263_19887448_ChIP-Seq_K562_Human1.19823402
78E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19310673
79CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18887804
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.18712858
81SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18643110
82PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18274121
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17647228
84SOX2_19829295_ChIP-Seq_ESCs_Human1.16509416
85NANOG_19829295_ChIP-Seq_ESCs_Human1.16509416
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16379799
87BCAT_22108803_ChIP-Seq_LS180_Human1.14387459
88* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14178586
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.13998105
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13590917
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13575339
92GATA2_21666600_ChIP-Seq_HMVEC_Human1.13345035
93* GATA3_27048872_Chip-Seq_THYMUS_Human1.12681958
94* NANOG_18555785_Chip-Seq_ESCs_Mouse1.12467136
95NANOG_20526341_ChIP-Seq_ESCs_Human1.12342802
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11979711
97BP1_19119308_ChIP-ChIP_Hs578T_Human1.11737961
98ESR1_21235772_ChIP-Seq_MCF-7_Human1.11571166
99TAL1_26923725_Chip-Seq_HPCs_Mouse1.11383630
100BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.10392505
101FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.09454605
102ELK1_22589737_ChIP-Seq_MCF10A_Human1.09191489
103CRX_20693478_ChIP-Seq_RETINA_Mouse1.08931435
104ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.07954910
105CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06965756
106MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05534778
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05160239
108KDM5A_27292631_Chip-Seq_BREAST_Human1.05125426
109* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04494941
110CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04227563
111SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04192419
112RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04050023
113BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03860387
114TFEB_21752829_ChIP-Seq_HELA_Human1.03523888
115TTF2_22483619_ChIP-Seq_HELA_Human1.03310848
116STAT3_23295773_ChIP-Seq_U87_Human1.03199640
117* STAT3_18555785_Chip-Seq_ESCs_Mouse1.02822750
118* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00115842
119TAF15_26573619_Chip-Seq_HEK293_Human0.99526624
120* P53_22387025_ChIP-Seq_ESCs_Mouse0.99372579
121WT1_19549856_ChIP-ChIP_CCG9911_Human0.99199024
122TCF4_23295773_ChIP-Seq_U87_Human0.98222038
123STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96605963
124FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96570966
125SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95661456
126FOXH1_21741376_ChIP-Seq_EPCs_Human0.95503194
127SMAD4_21799915_ChIP-Seq_A2780_Human0.95373505
128* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95261850
129GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94973334
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94742682
131AR_20517297_ChIP-Seq_VCAP_Human0.93862765
132GATA3_26560356_Chip-Seq_TH1_Human0.93283388
133* SPI1_23547873_ChIP-Seq_NB4_Human0.92718367
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92704832
135TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92319056
136MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.92279789
137SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92127249
138* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92106493
139* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91677691
140ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91345391
141* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90789451
142GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90764730
143CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90235353
144EP300_21415370_ChIP-Seq_HL-1_Mouse0.89883373
145CTCF_20526341_ChIP-Seq_ESCs_Human0.89726180
146IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.89341222
147TCF4_22108803_ChIP-Seq_LS180_Human0.88064031
148* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87298417
149TP63_17297297_ChIP-ChIP_HaCaT_Human0.85861783
150* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85691597
151YY1_22570637_ChIP-Seq_MALME-3M_Human0.83795276
152GATA3_21867929_ChIP-Seq_CD8_Mouse0.83688813
153ERG_20517297_ChIP-Seq_VCAP_Human0.83374441
154GABP_19822575_ChIP-Seq_HepG2_Human0.82236866
155* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.81660905
156GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81334723
157CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81021054
158* NFI_21473784_ChIP-Seq_ESCs_Mouse0.80867801
159TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80466985
160RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.79806902
161SOX11_22085726_ChIP-Seq_ESNs_Mouse0.78512029
162P63_26484246_Chip-Seq_KERATINOCYTES_Human0.77215386
163GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.73897020
164CIITA_25753668_ChIP-Seq_RAJI_Human0.72314501
165FOXA1_21572438_ChIP-Seq_LNCaP_Human0.70050112
166OCT4_20526341_ChIP-Seq_ESCs_Human0.69691491

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.99039682
2MP0000372_irregular_coat_pigmentation3.82650186
3MP0008877_abnormal_DNA_methylation3.68196107
4MP0008058_abnormal_DNA_repair3.39321325
5MP0006054_spinal_hemorrhage3.07088483
6MP0003806_abnormal_nucleotide_metabolis2.49721268
7MP0008789_abnormal_olfactory_epithelium2.38896199
8MP0002938_white_spotting2.31884451
9MP0003136_yellow_coat_color2.28765262
10MP0005379_endocrine/exocrine_gland_phen2.21524778
11MP0001485_abnormal_pinna_reflex2.20424509
12MP0003724_increased_susceptibility_to2.15231881
13MP0000013_abnormal_adipose_tissue2.13959033
14MP0002138_abnormal_hepatobiliary_system2.08006148
15MP0001984_abnormal_olfaction10.6915804
16MP0005645_abnormal_hypothalamus_physiol1.96323577
17MP0010094_abnormal_chromosome_stability1.83178194
18MP0001542_abnormal_bone_strength1.79196715
19MP0005257_abnormal_intraocular_pressure1.78719895
20MP0000569_abnormal_digit_pigmentation1.73485836
21MP0004381_abnormal_hair_follicle1.73346556
22MP0003693_abnormal_embryo_hatching1.72450525
23MP0005464_abnormal_platelet_physiology1.67910003
24MP0003111_abnormal_nucleus_morphology1.66782266
25MP0006072_abnormal_retinal_apoptosis1.64340144
26MP0001764_abnormal_homeostasis1.64101117
27MP0001835_abnormal_antigen_presentation1.62192935
28MP0002009_preneoplasia1.59883169
29MP0003718_maternal_effect1.59678051
30MP0005174_abnormal_tail_pigmentation1.59254624
31MP0003186_abnormal_redox_activity1.56390112
32MP0000003_abnormal_adipose_tissue1.52018984
33MP0005499_abnormal_olfactory_system1.45336838
34MP0005394_taste/olfaction_phenotype1.45336838
35MP0002295_abnormal_pulmonary_circulatio1.45142040
36MP0008007_abnormal_cellular_replicative1.45006057
37MP0005503_abnormal_tendon_morphology1.41892702
38MP0006036_abnormal_mitochondrial_physio1.41430382
39MP0001324_abnormal_eye_pigmentation1.35504124
40MP0004147_increased_porphyrin_level1.33160826
41MP0010678_abnormal_skin_adnexa1.32972417
42MP0002837_dystrophic_cardiac_calcinosis1.31592305
43MP0005409_darkened_coat_color1.31546041
44MP0004043_abnormal_pH_regulation1.30692074
45MP0001929_abnormal_gametogenesis1.30101185
46MP0005084_abnormal_gallbladder_morpholo1.29622462
47MP0005367_renal/urinary_system_phenotyp1.29525712
48MP0000516_abnormal_urinary_system1.29525712
49MP0002210_abnormal_sex_determination1.29489510
50MP0000427_abnormal_hair_cycle1.28902233
51MP0001756_abnormal_urination1.27112428
52MP0010386_abnormal_urinary_bladder1.26616319
53MP0008875_abnormal_xenobiotic_pharmacok1.25698887
54MP0002139_abnormal_hepatobiliary_system1.22525132
55MP0000566_synostosis1.21801444
56MP0001145_abnormal_male_reproductive1.21251475
57MP0003828_pulmonary_edema1.20498975
58MP0003878_abnormal_ear_physiology1.19717822
59MP0005377_hearing/vestibular/ear_phenot1.19717822
60MP0000383_abnormal_hair_follicle1.19123613
61MP0000653_abnormal_sex_gland1.18982486
62MP0005389_reproductive_system_phenotype1.16794095
63MP0009046_muscle_twitch1.15950861
64MP0005332_abnormal_amino_acid1.14694449
65MP0009333_abnormal_splenocyte_physiolog1.12789949
66MP0002928_abnormal_bile_duct1.12251566
67MP0005408_hypopigmentation1.10337216
68MP0003567_abnormal_fetal_cardiomyocyte1.09312552
69MP0002132_abnormal_respiratory_system1.08640248
70MP0010234_abnormal_vibrissa_follicle1.06401496
71MP0001944_abnormal_pancreas_morphology1.04154882
72MP0000613_abnormal_salivary_gland1.04106469
73MP0008438_abnormal_cutaneous_collagen1.03022222
74MP0005253_abnormal_eye_physiology1.02990300
75MP0003786_premature_aging1.02716045
76MP0001188_hyperpigmentation1.02668730
77MP0005551_abnormal_eye_electrophysiolog1.00921572
78MP0010368_abnormal_lymphatic_system1.00273553
79MP0005387_immune_system_phenotype0.99727106
80MP0001790_abnormal_immune_system0.99727106
81MP0005058_abnormal_lysosome_morphology0.97299898
82MP0004215_abnormal_myocardial_fiber0.96861474
83MP0003698_abnormal_male_reproductive0.96169549
84MP0004142_abnormal_muscle_tone0.96108515
85MP0004019_abnormal_vitamin_homeostasis0.94910502
86MP0005508_abnormal_skeleton_morphology0.94892200
87MP0005671_abnormal_response_to0.94431173
88MP0004808_abnormal_hematopoietic_stem0.92821068
89MP0000639_abnormal_adrenal_gland0.92280094
90MP0000049_abnormal_middle_ear0.91227993
91MP0002638_abnormal_pupillary_reflex0.90884273
92MP0002148_abnormal_hypersensitivity_rea0.90216774
93MP0001270_distended_abdomen0.90135762
94MP0005636_abnormal_mineral_homeostasis0.90116581
95MP0001346_abnormal_lacrimal_gland0.88312914
96MP0000767_abnormal_smooth_muscle0.88176266
97MP0003183_abnormal_peptide_metabolism0.88169876
98MP0000689_abnormal_spleen_morphology0.88035201
99MP0001529_abnormal_vocalization0.87959727
100MP0002160_abnormal_reproductive_system0.86607364
101MP0003077_abnormal_cell_cycle0.86410744
102MP0002693_abnormal_pancreas_physiology0.86274923
103MP0000685_abnormal_immune_system0.85923533
104MP0002163_abnormal_gland_morphology0.84195326
105MP0004264_abnormal_extraembryonic_tissu0.83458421
106MP0005410_abnormal_fertilization0.83394728
107MP0005319_abnormal_enzyme/_coenzyme0.82032710
108MP0000358_abnormal_cell_content/0.81898700
109MP0003195_calcinosis0.81087987
110MP0008775_abnormal_heart_ventricle0.80665819
111MP0003172_abnormal_lysosome_physiology0.79107153
112MP0005165_increased_susceptibility_to0.79039449
113MP0001119_abnormal_female_reproductive0.78883624
114MP0000681_abnormal_thyroid_gland0.78752079
115MP0003656_abnormal_erythrocyte_physiolo0.78594358
116MP0006292_abnormal_olfactory_placode0.78039034
117MP0002060_abnormal_skin_morphology0.77601161
118MP0002876_abnormal_thyroid_physiology0.76715536
119MP0005647_abnormal_sex_gland0.76250855
120MP0004145_abnormal_muscle_electrophysio0.75583590
121MP0008872_abnormal_physiological_respon0.75462601
122MP0005330_cardiomyopathy0.74918442
123MP0002736_abnormal_nociception_after0.73663992
124MP0005365_abnormal_bile_salt0.73541042
125MP0001545_abnormal_hematopoietic_system0.73323717
126MP0005397_hematopoietic_system_phenotyp0.73323717
127MP0001905_abnormal_dopamine_level0.73277075
128MP0001186_pigmentation_phenotype0.73153337
129MP0009643_abnormal_urine_homeostasis0.72298891
130MP0005220_abnormal_exocrine_pancreas0.70558918
131MP0003795_abnormal_bone_structure0.70072924
132MP0002095_abnormal_skin_pigmentation0.69483807
133MP0002405_respiratory_system_inflammati0.68909023
134MP0002078_abnormal_glucose_homeostasis0.68826737
135MP0002896_abnormal_bone_mineralization0.68270017
136MP0005075_abnormal_melanosome_morpholog0.67246123
137MP0000026_abnormal_inner_ear0.66035504
138MP0000749_muscle_degeneration0.63966030
139MP0002909_abnormal_adrenal_gland0.63603898
140MP0003943_abnormal_hepatobiliary_system0.62513712
141MP0003941_abnormal_skin_development0.62318134
142MP0000015_abnormal_ear_pigmentation0.59441073
143MP0004036_abnormal_muscle_relaxation0.58531652
144MP0009697_abnormal_copulation0.58368029
145MP0001879_abnormal_lymphatic_vessel0.58280374
146MP0005375_adipose_tissue_phenotype0.57157778
147MP0005275_abnormal_skin_tensile0.56868780
148MP0002177_abnormal_outer_ear0.55342123
149MP0008057_abnormal_DNA_replication0.54890977
150MP0000371_diluted_coat_color0.54723635
151MP0000428_abnormal_craniofacial_morphol0.54427583
152MP0001299_abnormal_eye_distance/0.54258680
153MP0001986_abnormal_taste_sensitivity0.54085755
154MP0000465_gastrointestinal_hemorrhage0.54035143
155MP0002075_abnormal_coat/hair_pigmentati0.52416809
156MP0004272_abnormal_basement_membrane0.52185782
157MP0000538_abnormal_urinary_bladder0.51863270
158MP0005646_abnormal_pituitary_gland0.51425995
159MP0010030_abnormal_orbit_morphology0.51348350
160MP0003279_aneurysm0.51103101
161MP0002166_altered_tumor_susceptibility0.50478742
162MP0002233_abnormal_nose_morphology0.50393426
163MP0000230_abnormal_systemic_arterial0.50065553

Predicted human phenotypes

RankGene SetZ-score
1Retinal dysplasia (HP:0007973)6.22320545
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.80772183
3Bifid tongue (HP:0010297)4.69233467
4Molar tooth sign on MRI (HP:0002419)4.69133913
5Abnormality of midbrain morphology (HP:0002418)4.69133913
6Palpitations (HP:0001962)4.22167323
7Hypothermia (HP:0002045)4.21645700
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.96112485
9Stomach cancer (HP:0012126)3.75206042
10Hyperphosphatemia (HP:0002905)3.64754774
11True hermaphroditism (HP:0010459)3.53984831
12Vacuolated lymphocytes (HP:0001922)3.48527075
13Acute necrotizing encephalopathy (HP:0006965)3.38720646
14Abnormality of calcium-phosphate metabolism (HP:0100530)3.32962510
15Abnormal respiratory motile cilium morphology (HP:0005938)3.29224219
16Abnormal respiratory epithelium morphology (HP:0012253)3.29224219
17Abnormal respiratory motile cilium physiology (HP:0012261)3.21875665
183-Methylglutaconic aciduria (HP:0003535)3.16166857
19Pulmonary artery stenosis (HP:0004415)3.14771326
20Rhinitis (HP:0012384)3.14678617
21Ketoacidosis (HP:0001993)3.12419659
22Type I transferrin isoform profile (HP:0003642)3.09724690
23Abnormal mitochondria in muscle tissue (HP:0008316)3.09030085
24Abnormal ciliary motility (HP:0012262)3.02353792
25Delayed CNS myelination (HP:0002188)2.97904637
26Congenital primary aphakia (HP:0007707)2.97506489
27Medial flaring of the eyebrow (HP:0010747)2.96038398
28Renal cortical cysts (HP:0000803)2.93341352
29Abnormality of the fovea (HP:0000493)2.87882791
30Pancreatic fibrosis (HP:0100732)2.85772484
31Abnormality of the renal cortex (HP:0011035)2.84666285
32Progressive macrocephaly (HP:0004481)2.83950511
33Abnormality of endocrine pancreas physiology (HP:0012093)2.82498233
34Abnormality of the pancreatic islet cells (HP:0006476)2.82498233
35Hypoplasia of the fovea (HP:0007750)2.82070212
36Aplasia/Hypoplasia of the fovea (HP:0008060)2.82070212
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.76037667
38Pancreatic cysts (HP:0001737)2.75987387
39Metaphyseal dysplasia (HP:0100255)2.70448929
40Short nail (HP:0001799)2.67303853
41Hypoplasia of the uterus (HP:0000013)2.64799750
42Acute encephalopathy (HP:0006846)2.63918782
43Methylmalonic acidemia (HP:0002912)2.61511161
44Nephrogenic diabetes insipidus (HP:0009806)2.61192677
45Fair hair (HP:0002286)2.60128800
46Reduced antithrombin III activity (HP:0001976)2.59862329
47Bony spicule pigmentary retinopathy (HP:0007737)2.58266495
48Vaginal atresia (HP:0000148)2.57544043
49Gait imbalance (HP:0002141)2.55623383
50Hematochezia (HP:0002573)2.53937312
51Ketosis (HP:0001946)2.53218512
52Occipital encephalocele (HP:0002085)2.52417886
53Abolished electroretinogram (ERG) (HP:0000550)2.50317055
54Agammaglobulinemia (HP:0004432)2.46227666
55Xerostomia (HP:0000217)2.44878807
56Villous atrophy (HP:0011473)2.44666277
57Abnormality of small intestinal villus morphology (HP:0011472)2.44666277
58Generalized aminoaciduria (HP:0002909)2.44499755
59Abnormality of T cell physiology (HP:0011840)2.42077429
60Panhypogammaglobulinemia (HP:0003139)2.40900504
61Abnormality of dentin (HP:0010299)2.37875898
62Genital tract atresia (HP:0001827)2.37358679
63Hypoglycemic seizures (HP:0002173)2.37350391
64Median cleft lip (HP:0000161)2.37165866
65Mitochondrial inheritance (HP:0001427)2.36120120
66Increased CSF lactate (HP:0002490)2.31991011
67Hyperinsulinemic hypoglycemia (HP:0000825)2.30199927
68Chronic bronchitis (HP:0004469)2.29091652
69Aplasia/hypoplasia of the uterus (HP:0008684)2.22933712
70Thyroid carcinoma (HP:0002890)2.22763861
71Hyperglycinemia (HP:0002154)2.21322278
72Chronic hepatic failure (HP:0100626)2.19452704
73Syncope (HP:0001279)2.19226537
74Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16669307
75Abnormal protein N-linked glycosylation (HP:0012347)2.16669307
76Abnormal protein glycosylation (HP:0012346)2.16669307
77Abnormal glycosylation (HP:0012345)2.16669307
78Aplasia/Hypoplasia of the lens (HP:0008063)2.14636415
79Neoplasm of the adrenal cortex (HP:0100641)2.13122835
80Papillary thyroid carcinoma (HP:0002895)2.12545929
81Generalized hypopigmentation of hair (HP:0011358)2.11557632
82Pancreatic islet-cell hyperplasia (HP:0004510)2.11350229
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.10214828
84Stomatitis (HP:0010280)2.09444811
85Hypoglycemic coma (HP:0001325)2.08096462
86Hepatic necrosis (HP:0002605)2.06438624
87Aortic regurgitation (HP:0001659)2.06197008
88Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05665182
89Methylmalonic aciduria (HP:0012120)2.05123636
90Hepatocellular necrosis (HP:0001404)2.03890806
91Facial cleft (HP:0002006)2.03801156
92Increased serum lactate (HP:0002151)2.01742504
93Abnormality of dental color (HP:0011073)2.00670191
94Supernumerary spleens (HP:0009799)2.00566682
95Tubulointerstitial nephritis (HP:0001970)2.00008310
96Renal Fanconi syndrome (HP:0001994)1.99722591
97Cutaneous melanoma (HP:0012056)1.99649280
98Late onset (HP:0003584)1.98594249
99Dysostosis multiplex (HP:0000943)1.97829953
100Neutropenia (HP:0001875)1.97180143
101Albinism (HP:0001022)1.96936888
102Absent eyebrow (HP:0002223)1.95866756
103Limb dystonia (HP:0002451)1.94900261
104Short chin (HP:0000331)1.92697234
105Abnormality of B cell number (HP:0010975)1.92424639
106Lipid accumulation in hepatocytes (HP:0006561)1.92237079
107Exercise intolerance (HP:0003546)1.92231950
108Abnormality of macular pigmentation (HP:0008002)1.91801414
109Abnormality of fatty-acid metabolism (HP:0004359)1.91753794
110Hyperglycemia (HP:0003074)1.90228698
111Nephronophthisis (HP:0000090)1.89668934
112Dysphonia (HP:0001618)1.89480722
113Abnormal rod and cone electroretinograms (HP:0008323)1.89130935
114Increased hepatocellular lipid droplets (HP:0006565)1.88920828
115Dry hair (HP:0011359)1.88750728
116Progressive microcephaly (HP:0000253)1.88657323
117Abnormal drinking behavior (HP:0030082)1.88637615
118Polydipsia (HP:0001959)1.88637615
119Furrowed tongue (HP:0000221)1.86464396
120Bronchiectasis (HP:0002110)1.86330082
121Beaking of vertebral bodies (HP:0004568)1.85611715
122Type II lissencephaly (HP:0007260)1.85246516
123Glycosuria (HP:0003076)1.84622837
124Abnormality of urine glucose concentration (HP:0011016)1.84622837
125Widely spaced teeth (HP:0000687)1.84304042
126Abnormality of the dental pulp (HP:0006479)1.84265201
127Severe visual impairment (HP:0001141)1.83985452
128Decreased circulating renin level (HP:0003351)1.83561190
129Poor coordination (HP:0002370)1.82718483
130Abnormal biliary tract physiology (HP:0012439)1.82391646
131Bile duct proliferation (HP:0001408)1.82391646
132Postaxial hand polydactyly (HP:0001162)1.82365060
133Cystic liver disease (HP:0006706)1.82247288
134Abnormality of vitamin B metabolism (HP:0004340)1.81454382
135Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79742011
136Cerebral edema (HP:0002181)1.79422993
137Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79298008
138Abnormality of the periventricular white matter (HP:0002518)1.78803738
139Neoplasm of the adrenal gland (HP:0100631)1.78048421
140Abnormal number of erythroid precursors (HP:0012131)1.78035597
141Abnormality of molar morphology (HP:0011070)1.77925085
142Abnormality of molar (HP:0011077)1.77925085
143Prolonged QT interval (HP:0001657)1.77847100
144Increased IgM level (HP:0003496)1.77832494
145Dicarboxylic aciduria (HP:0003215)1.77689049
146Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77689049
147Abnormality of aromatic amino acid family metabolism (HP:0004338)1.77307827
148Bell-shaped thorax (HP:0001591)1.76924592
149Oculomotor apraxia (HP:0000657)1.76738657
150Birth length less than 3rd percentile (HP:0003561)1.74901029
151Synostosis involving the elbow (HP:0003938)1.73727796
152Humeroradial synostosis (HP:0003041)1.73727796
153Abnormality of methionine metabolism (HP:0010901)1.73717146
154Abnormality of the renal medulla (HP:0100957)1.73433607
155Microvesicular hepatic steatosis (HP:0001414)1.72684860
156Abnormality of permanent molar morphology (HP:0011071)1.72221295
157Abnormality of the dental root (HP:0006486)1.72221295
158Taurodontia (HP:0000679)1.72221295
159Abnormality of cells of the erythroid lineage (HP:0012130)1.72195565
160Azoospermia (HP:0000027)1.71986879
161Left ventricular hypertrophy (HP:0001712)1.71862119
162Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.71431316
163Decreased activity of mitochondrial respiratory chain (HP:0008972)1.71431316
164Congenital, generalized hypertrichosis (HP:0004540)1.70633343
165Respiratory failure (HP:0002878)1.70421862
166Split foot (HP:0001839)1.67678435
167Abnormality of macrophages (HP:0004311)1.67064911
168Male pseudohermaphroditism (HP:0000037)1.66460761
169Lactic acidosis (HP:0003128)1.65729085
170Abnormality of the heme biosynthetic pathway (HP:0010472)1.65120593
171Neuroendocrine neoplasm (HP:0100634)1.64643283
172Congenital hepatic fibrosis (HP:0002612)1.64348544
173Aganglionic megacolon (HP:0002251)1.63307765
174Thoracolumbar scoliosis (HP:0002944)1.63104857
175Abnormality of alanine metabolism (HP:0010916)1.61725067
176Hyperalaninemia (HP:0003348)1.61725067
177Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.61725067

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.53712751
2MAPK154.27748165
3MAP3K104.12393122
4TNIK3.03292320
5STK162.99676004
6MKNK22.62976704
7MAP4K22.61286667
8FRK2.40237289
9FLT32.38058924
10IRAK32.37409223
11NME22.33935504
12ERBB32.28368955
13PHKG22.22764183
14PHKG12.22764183
15ZAK2.20717225
16PLK21.93771721
17INSRR1.91255801
18IRAK11.88831680
19HIPK21.88337858
20NLK1.83975417
21DYRK31.83919378
22BCKDK1.76977408
23CAMKK21.73259696
24BMPR21.69339771
25MST41.63783799
26SCYL21.60629071
27MKNK11.51965269
28TRPM71.51391140
29MUSK1.49467154
30PDK21.49243874
31SRPK11.47740465
32YES11.46611254
33MYLK1.44161661
34GRK11.43861425
35CAMK2D1.43677162
36PIM21.42429233
37NEK11.41904884
38BRSK21.40344488
39VRK11.34261765
40PBK1.33718071
41IRAK41.33305239
42PASK1.33181720
43EIF2AK31.30404537
44NUAK11.28759617
45TGFBR21.28443012
46BRAF1.28110262
47STK381.24972122
48CAMK2B1.24662158
49PLK41.22340212
50BMPR1B1.21791138
51DAPK21.21293248
52FGFR21.20306330
53CAMK2G1.19687350
54MAPKAPK51.15947429
55PAK31.15447927
56MAP3K141.09337110
57CSNK1A1L1.07219994
58ITK1.07063598
59TIE11.06317794
60KIT0.99976395
61WEE10.97590454
62STK390.96256172
63TEC0.95329856
64MAP3K120.94850744
65OBSCN0.93195640
66MAP2K20.93098658
67TYK20.91605587
68PRKCI0.90938597
69CSNK1G30.90403490
70RPS6KA40.89270065
71EPHA30.87868807
72ACVR1B0.87323899
73CDK80.86623941
74TLK10.86456414
75CSNK1G10.84630580
76TTK0.84085035
77PLK30.82883744
78CDK30.78832299
79CDC70.76557945
80IKBKB0.76329795
81DYRK1B0.76144470
82ARAF0.75554672
83DAPK10.72189215
84TXK0.72022985
85MAP3K130.71385676
86OXSR10.69310941
87TGFBR10.68842472
88STK240.68428439
89PIK3CG0.67947792
90FGFR30.66463014
91RPS6KA50.64224017
92PLK10.63410150
93JAK30.62421655
94GRK70.61898981
95ADRBK20.61693748
96TNK20.61664002
97NEK60.61505713
98WNK40.57665252
99CLK10.57662399
100BUB10.57605205
101MAPKAPK20.55814548
102BTK0.53007741
103RIPK10.51576174
104CCNB10.51377348
105MAPKAPK30.49938862
106MAP3K30.49933240
107ATM0.48249899
108TBK10.46134995
109TAF10.45523437
110MAP3K20.45292019
111WNK30.41502275
112STK100.39630269
113TRIM280.39440976
114MET0.39437350
115IRAK20.38927269
116STK30.38873617
117EIF2AK20.37741076
118STK38L0.37433031
119PRKCQ0.36755488
120PRKCG0.35705429
121CDK190.35506422
122CDK70.35070783
123SYK0.34710827
124CAMK10.34575849
125IGF1R0.33892988
126PINK10.33219743
127AKT30.33159642
128MAP3K40.33137084
129PRKCE0.33124419
130PRKAA20.30915640
131IKBKE0.30780543
132BCR0.30018843
133CDK90.30014551
134CSF1R0.29998145
135ADRBK10.29749854
136CHEK20.29307591
137CSNK2A10.28929095
138PRKD20.28922386
139LYN0.27670545
140PIK3CA0.27657840
141MATK0.27533078
142CSNK2A20.27524208
143PRKACB0.27290713
144EGFR0.26716646
145KDR0.25816302
146DYRK1A0.25545538
147CSNK1G20.23306858

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047406.17648300
2Protein export_Homo sapiens_hsa030603.99406171
3Asthma_Homo sapiens_hsa053103.13239787
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.92418028
5Oxidative phosphorylation_Homo sapiens_hsa001902.79642594
6Other glycan degradation_Homo sapiens_hsa005112.74816389
7Parkinsons disease_Homo sapiens_hsa050122.71761015
8Sphingolipid metabolism_Homo sapiens_hsa006002.41794413
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40368363
10Ribosome_Homo sapiens_hsa030102.24168926
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.21290932
12Allograft rejection_Homo sapiens_hsa053302.20581602
13Autoimmune thyroid disease_Homo sapiens_hsa053202.08019874
14Type I diabetes mellitus_Homo sapiens_hsa049402.07244228
15Peroxisome_Homo sapiens_hsa041462.06541902
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.89908002
17Arachidonic acid metabolism_Homo sapiens_hsa005901.88615113
18Collecting duct acid secretion_Homo sapiens_hsa049661.87887131
19Alzheimers disease_Homo sapiens_hsa050101.85641769
20RNA polymerase_Homo sapiens_hsa030201.83063994
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.82350486
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82137251
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.81038940
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71517418
25Graft-versus-host disease_Homo sapiens_hsa053321.66611528
26Huntingtons disease_Homo sapiens_hsa050161.64985157
27Purine metabolism_Homo sapiens_hsa002301.60319969
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53089361
29Basal transcription factors_Homo sapiens_hsa030221.51257293
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51139113
31Proteasome_Homo sapiens_hsa030501.47507153
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47062683
33Sulfur metabolism_Homo sapiens_hsa009201.42653825
34Fatty acid metabolism_Homo sapiens_hsa012121.40147156
35Vibrio cholerae infection_Homo sapiens_hsa051101.38672953
36Pyrimidine metabolism_Homo sapiens_hsa002401.34999949
37Butanoate metabolism_Homo sapiens_hsa006501.26606454
38Selenocompound metabolism_Homo sapiens_hsa004501.22843813
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.15686368
40Vitamin B6 metabolism_Homo sapiens_hsa007501.14635073
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10870153
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07886649
43One carbon pool by folate_Homo sapiens_hsa006701.07767624
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.07680491
45Phototransduction_Homo sapiens_hsa047441.05436903
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04390112
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03912013
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01825101
49Antigen processing and presentation_Homo sapiens_hsa046121.00926581
50Fatty acid degradation_Homo sapiens_hsa000711.00790851
51Insulin secretion_Homo sapiens_hsa049111.00309497
52Nitrogen metabolism_Homo sapiens_hsa009101.00253940
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00229972
54N-Glycan biosynthesis_Homo sapiens_hsa005100.97994199
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.97471546
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95175226
57Ovarian steroidogenesis_Homo sapiens_hsa049130.92045332
58Ether lipid metabolism_Homo sapiens_hsa005650.91386279
59Oocyte meiosis_Homo sapiens_hsa041140.91140997
60Histidine metabolism_Homo sapiens_hsa003400.89572274
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89114903
62Retinol metabolism_Homo sapiens_hsa008300.88662601
63Lysosome_Homo sapiens_hsa041420.88228369
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84244096
65Staphylococcus aureus infection_Homo sapiens_hsa051500.82258189
66Malaria_Homo sapiens_hsa051440.82084731
67Cardiac muscle contraction_Homo sapiens_hsa042600.80703334
68Regulation of autophagy_Homo sapiens_hsa041400.78415323
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.78215349
70Dorso-ventral axis formation_Homo sapiens_hsa043200.77797859
71Linoleic acid metabolism_Homo sapiens_hsa005910.75751374
72Circadian rhythm_Homo sapiens_hsa047100.73022434
73Primary immunodeficiency_Homo sapiens_hsa053400.71822431
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69724042
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69416126
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68782021
77Legionellosis_Homo sapiens_hsa051340.68590761
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.67836132
79RNA transport_Homo sapiens_hsa030130.65625574
80Homologous recombination_Homo sapiens_hsa034400.65480960
81Caffeine metabolism_Homo sapiens_hsa002320.64218760
82Non-homologous end-joining_Homo sapiens_hsa034500.64127313
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62173340
84cAMP signaling pathway_Homo sapiens_hsa040240.61533459
85Leishmaniasis_Homo sapiens_hsa051400.60003212
86Glutathione metabolism_Homo sapiens_hsa004800.58540475
87Pyruvate metabolism_Homo sapiens_hsa006200.58142462
88Spliceosome_Homo sapiens_hsa030400.56736501
89Mismatch repair_Homo sapiens_hsa034300.56712013
90DNA replication_Homo sapiens_hsa030300.55079786
91Herpes simplex infection_Homo sapiens_hsa051680.54198051
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.53944207
93Sulfur relay system_Homo sapiens_hsa041220.53432048
94Hematopoietic cell lineage_Homo sapiens_hsa046400.53426510
95Taste transduction_Homo sapiens_hsa047420.52331775
96Notch signaling pathway_Homo sapiens_hsa043300.50928954
97Metabolic pathways_Homo sapiens_hsa011000.50209965
98ABC transporters_Homo sapiens_hsa020100.47884761
99ECM-receptor interaction_Homo sapiens_hsa045120.45751655
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45693418
101beta-Alanine metabolism_Homo sapiens_hsa004100.45271000
102Nucleotide excision repair_Homo sapiens_hsa034200.45216227
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45084792
104Rheumatoid arthritis_Homo sapiens_hsa053230.44957170
105Dilated cardiomyopathy_Homo sapiens_hsa054140.44076483
106Viral myocarditis_Homo sapiens_hsa054160.43485265
107Thyroid hormone synthesis_Homo sapiens_hsa049180.42632594
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41644648
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41376424
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41230299
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40714479
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40632707
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39811792
114Fanconi anemia pathway_Homo sapiens_hsa034600.39362277
115Vitamin digestion and absorption_Homo sapiens_hsa049770.38631014
116Long-term depression_Homo sapiens_hsa047300.38327656
117Chemical carcinogenesis_Homo sapiens_hsa052040.38122255
118RNA degradation_Homo sapiens_hsa030180.37617589
119Pentose phosphate pathway_Homo sapiens_hsa000300.35847085
120Tryptophan metabolism_Homo sapiens_hsa003800.35814904
121Cell cycle_Homo sapiens_hsa041100.35729967
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35391218
123p53 signaling pathway_Homo sapiens_hsa041150.34262760
124Folate biosynthesis_Homo sapiens_hsa007900.34231406
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33802550
126Base excision repair_Homo sapiens_hsa034100.32747177
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31564154
128TNF signaling pathway_Homo sapiens_hsa046680.31526993
129Systemic lupus erythematosus_Homo sapiens_hsa053220.31427288
130Protein digestion and absorption_Homo sapiens_hsa049740.31220495
131Starch and sucrose metabolism_Homo sapiens_hsa005000.30598244
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.30394078
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.30311593
134Propanoate metabolism_Homo sapiens_hsa006400.28927349
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28158676
136NF-kappa B signaling pathway_Homo sapiens_hsa040640.26750260
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25788700
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23902092
139Fatty acid elongation_Homo sapiens_hsa000620.23882343
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22903555
141HTLV-I infection_Homo sapiens_hsa051660.22790240
142Prostate cancer_Homo sapiens_hsa052150.22202346
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21936715
144Amoebiasis_Homo sapiens_hsa051460.21476805

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