WDTC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline metabolic process (GO:0006560)7.96661383
2transcription from mitochondrial promoter (GO:0006390)7.57391381
3embryonic process involved in female pregnancy (GO:0060136)7.09942683
4positive regulation of protein homooligomerization (GO:0032464)6.13495101
5replication fork processing (GO:0031297)6.12847178
6establishment of apical/basal cell polarity (GO:0035089)5.84826600
7regulation of integrin activation (GO:0033623)5.83005025
8oxidative demethylation (GO:0070989)5.77278833
9regulation of protein homooligomerization (GO:0032462)5.60250900
10mitochondrial DNA metabolic process (GO:0032042)5.20959562
11establishment or maintenance of monopolar cell polarity (GO:0061339)5.02127486
12establishment of monopolar cell polarity (GO:0061162)5.02127486
13glutamine family amino acid biosynthetic process (GO:0009084)4.99755183
14negative regulation of erythrocyte differentiation (GO:0045647)4.96045556
15maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.89833228
16mitotic G1 DNA damage checkpoint (GO:0031571)4.86908003
17embryonic placenta development (GO:0001892)4.82895130
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.76778556
19negative regulation of cell killing (GO:0031342)4.76778556
20DNA deamination (GO:0045006)4.75891101
21sulfur amino acid catabolic process (GO:0000098)4.72537135
22regulation of translational fidelity (GO:0006450)4.46619490
23somatic diversification of immune receptors via somatic mutation (GO:0002566)4.41300988
24somatic hypermutation of immunoglobulin genes (GO:0016446)4.41300988
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.36218261
26mitotic G1/S transition checkpoint (GO:0044819)4.30783762
27poly(A)+ mRNA export from nucleus (GO:0016973)4.30201636
28positive regulation of gamma-delta T cell activation (GO:0046645)4.27916579
29G1 DNA damage checkpoint (GO:0044783)4.24848155
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.22587108
31negative regulation of JAK-STAT cascade (GO:0046426)4.11324834
32DNA strand renaturation (GO:0000733)4.10178129
33mRNA cleavage (GO:0006379)4.07298173
34antigen processing and presentation of endogenous antigen (GO:0019883)3.99951246
35negative regulation of protein oligomerization (GO:0032460)3.97570170
36negative regulation of Ras GTPase activity (GO:0034261)3.95960770
37positive regulation by symbiont of host defense response (GO:0052509)3.93963483
38modulation by symbiont of host defense response (GO:0052031)3.93963483
39modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.93963483
40modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.93963483
41positive regulation by organism of defense response of other organism involved in symbiotic interact3.93963483
42modulation by symbiont of host immune response (GO:0052553)3.93963483
43antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.85511613
44spliceosomal tri-snRNP complex assembly (GO:0000244)3.83619541
45cellular response to ATP (GO:0071318)3.80638581
46negative regulation of cell cycle arrest (GO:0071157)3.76569671
47detection of other organism (GO:0098543)3.73456482
48labyrinthine layer development (GO:0060711)3.72237638
49detection of bacterium (GO:0016045)3.66647879
50positive regulation of protein oligomerization (GO:0032461)3.58110619
51very-low-density lipoprotein particle assembly (GO:0034379)3.56963662
52negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.56256480
53trophectodermal cell differentiation (GO:0001829)3.53291481
54apoptotic process involved in morphogenesis (GO:0060561)3.53058857
55positive regulation of mitotic sister chromatid separation (GO:1901970)3.52869693
56positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.52869693
57positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.52869693
58regulation of protein oligomerization (GO:0032459)3.52063308
59positive regulation by host of viral transcription (GO:0043923)3.51664386
60regulation of RNA export from nucleus (GO:0046831)3.51534199
61histone H4-K12 acetylation (GO:0043983)3.46977699
62regulation of gamma-delta T cell activation (GO:0046643)3.45475632
63convergent extension (GO:0060026)3.45391335
64regulation of cholesterol homeostasis (GO:2000188)3.43481944
65dosage compensation (GO:0007549)3.38632322
66macrophage activation involved in immune response (GO:0002281)3.37115091
67alkaloid metabolic process (GO:0009820)3.36773740
68embryonic camera-type eye development (GO:0031076)3.36442587
69regulation of hippo signaling (GO:0035330)3.33266717
70regulation of gamma-delta T cell differentiation (GO:0045586)3.32716826
71viral mRNA export from host cell nucleus (GO:0046784)3.31444198
72heme transport (GO:0015886)3.30997704
73intestinal cholesterol absorption (GO:0030299)3.27161584
74establishment of protein localization to mitochondrial membrane (GO:0090151)3.25760035
75regulation of sister chromatid cohesion (GO:0007063)3.23322233
76formation of translation preinitiation complex (GO:0001731)3.20556107
77anatomical structure regression (GO:0060033)3.19580161
78base-excision repair (GO:0006284)3.17559217
79detection of external biotic stimulus (GO:0098581)3.16072303
80response to peptidoglycan (GO:0032494)3.14736972
81negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.13323407
82mitochondrial RNA metabolic process (GO:0000959)3.10369965
83mannose metabolic process (GO:0006013)3.09043953
84protein localization to endosome (GO:0036010)3.08946322
85germinal center formation (GO:0002467)3.07158660
86negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06226641
87intracellular estrogen receptor signaling pathway (GO:0030520)3.05106944
88positive regulation of developmental pigmentation (GO:0048087)3.04842744
89anterior/posterior axis specification, embryo (GO:0008595)3.04517390
90regulation of B cell receptor signaling pathway (GO:0050855)3.03857399
91negative regulation of lymphocyte mediated immunity (GO:0002707)3.03497571
92cellular response to zinc ion (GO:0071294)3.03049328
93neutrophil activation involved in immune response (GO:0002283)3.02797028
94cellular extravasation (GO:0045123)3.02036276
95positive thymic T cell selection (GO:0045059)3.00909676
96regulation of gene silencing by RNA (GO:0060966)3.00098862
97regulation of posttranscriptional gene silencing (GO:0060147)3.00098862
98regulation of gene silencing by miRNA (GO:0060964)3.00098862
99leukocyte aggregation (GO:0070486)2.98999573
100face development (GO:0060324)2.98099084
101regulation of protein polyubiquitination (GO:1902914)2.96276391
102regulation of T-helper 2 cell differentiation (GO:0045628)2.94923321
103DNA integration (GO:0015074)2.93599464
104nodal signaling pathway (GO:0038092)2.93319099
105regulation of leukocyte degranulation (GO:0043300)2.89080493
106epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.88959864
107regulation of cAMP-dependent protein kinase activity (GO:2000479)2.88583908
108response to muramyl dipeptide (GO:0032495)2.88508083
109cytolysis (GO:0019835)2.88471595
110serine family amino acid catabolic process (GO:0009071)2.87988059
111double-strand break repair via nonhomologous end joining (GO:0006303)2.87575805
112non-recombinational repair (GO:0000726)2.87575805
113regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.87541448
114detection of molecule of bacterial origin (GO:0032490)2.87361753
115carnitine shuttle (GO:0006853)2.86474791
116retinoic acid receptor signaling pathway (GO:0048384)2.85244089
117hypotonic response (GO:0006971)2.84967323
118negative regulation of leukocyte mediated immunity (GO:0002704)2.84746897
119regulation of myeloid leukocyte mediated immunity (GO:0002886)2.83946376
120glyoxylate metabolic process (GO:0046487)2.83290404
121positive regulation of Rap GTPase activity (GO:0032854)2.83205473
122regulation of mast cell degranulation (GO:0043304)2.82762662
123regulation of ARF protein signal transduction (GO:0032012)2.82694085
124B cell receptor signaling pathway (GO:0050853)2.81644504
125meiotic chromosome segregation (GO:0045132)2.80339630
126glial cell migration (GO:0008347)2.80149345
127activation of Rac GTPase activity (GO:0032863)2.79953350
128signal complex assembly (GO:0007172)2.79126094
129regulation of podosome assembly (GO:0071801)2.78111140
130protein targeting to vacuole (GO:0006623)2.77892267
131protein targeting to lysosome (GO:0006622)2.77892267
132establishment of protein localization to vacuole (GO:0072666)2.77892267
133detection of biotic stimulus (GO:0009595)2.74970884
134regulation of nucleobase-containing compound transport (GO:0032239)2.74384923
135thymic T cell selection (GO:0045061)2.74004464
136regulation of cilium movement (GO:0003352)2.73729715
137fatty acid transmembrane transport (GO:1902001)2.73676657
138negative regulation of mRNA processing (GO:0050686)2.72231390
139negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.70658651
140determination of adult lifespan (GO:0008340)2.70513782
141erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.69926570
142regulation of necroptotic process (GO:0060544)2.68231078
1433-UTR-mediated mRNA stabilization (GO:0070935)2.65555136
144regulation of ARF GTPase activity (GO:0032312)2.64753089
145negative regulation of toll-like receptor signaling pathway (GO:0034122)2.63721864
146regulation of interferon-beta biosynthetic process (GO:0045357)2.63113930
147negative regulation of type 2 immune response (GO:0002829)2.62623801
148response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.61547824
149response to host (GO:0075136)2.61547824
150response to host defenses (GO:0052200)2.61547824
151response to host immune response (GO:0052572)2.60903398
152response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.60903398
153response to interleukin-15 (GO:0070672)2.57366773
154positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.57006803
155negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.55953164
156positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.54092124
157regulation of regulated secretory pathway (GO:1903305)2.53071118
158response to laminar fluid shear stress (GO:0034616)2.48092616
159T cell selection (GO:0045058)2.47442669
160negative regulation of myotube differentiation (GO:0010832)2.46473108
161oxygen transport (GO:0015671)2.46374528
162regulation of mast cell activation involved in immune response (GO:0033006)2.45990353
163barbed-end actin filament capping (GO:0051016)2.44926954
164positive regulation of cellular amide metabolic process (GO:0034250)2.43124492
165positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.43071891
166cellular response to epinephrine stimulus (GO:0071872)2.42467035
167negative regulation of necroptotic process (GO:0060546)2.41132537
168stress fiber assembly (GO:0043149)2.40769459
169positive regulation of receptor recycling (GO:0001921)2.39152453
170negative regulation of interleukin-12 production (GO:0032695)2.38952368
171negative thymic T cell selection (GO:0045060)2.38816683
172antigen processing and presentation via MHC class Ib (GO:0002475)2.38323015
173positive regulation of myotube differentiation (GO:0010831)2.37905303
174positive regulation of Cdc42 GTPase activity (GO:0043089)2.37223843
175negative regulation of T cell mediated immunity (GO:0002710)2.37055227
176regulation of platelet aggregation (GO:0090330)2.37035510
177modulation by symbiont of host cellular process (GO:0044068)2.36977797
178macrophage activation (GO:0042116)2.35490807
179gas transport (GO:0015669)2.34631974
180regulation of tolerance induction (GO:0002643)2.33635401
181tolerance induction (GO:0002507)2.32244026
182negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.31925883
183negative regulation of phagocytosis (GO:0050765)2.31392774
184actin filament polymerization (GO:0030041)2.30745471
185modulation by virus of host process (GO:0019054)2.30402535
186leukocyte migration involved in inflammatory response (GO:0002523)2.30310824
187positive T cell selection (GO:0043368)2.29886966
188positive regulation of B cell differentiation (GO:0045579)2.29546997
189response to type I interferon (GO:0034340)2.28928132
190creatine metabolic process (GO:0006600)2.28131247
191positive regulation of histone deacetylation (GO:0031065)2.28116404
192neutrophil activation (GO:0042119)2.27645441
193cellular response to type I interferon (GO:0071357)2.26550498
194type I interferon signaling pathway (GO:0060337)2.26550498
195regulation of macrophage cytokine production (GO:0010935)2.26047950
196regulation of Rap GTPase activity (GO:0032317)2.26033384
197immunoglobulin mediated immune response (GO:0016064)2.25211451
198proline biosynthetic process (GO:0006561)10.1269983

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.34509931
2ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.04297192
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.98084172
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.98084172
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.98084172
6SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.84135422
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.48978330
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.47975777
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.42098865
10* RXR_22158963_ChIP-Seq_LIVER_Mouse2.41107544
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.41083443
12SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.35314932
13LXR_22292898_ChIP-Seq_THP-1_Human2.23260134
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.22479639
15POU5F1_16518401_ChIP-PET_MESCs_Mouse2.17191912
16VDR_21846776_ChIP-Seq_THP-1_Human2.16232090
17VDR_24763502_ChIP-Seq_THP-1_Human2.14392822
18PPARA_22158963_ChIP-Seq_LIVER_Mouse2.14125631
19NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.11987308
20ZNF263_19887448_ChIP-Seq_K562_Human2.11041694
21KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.06472330
22DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.04941428
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.98957330
24STAT3_1855785_ChIP-Seq_MESCs_Mouse1.98043713
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.97539631
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.97404171
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.96786975
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96476954
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.92791300
30TCF3_18692474_ChIP-Seq_MESCs_Mouse1.92338856
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91365416
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.90877292
33* MAF_26560356_Chip-Seq_TH1_Human1.89994549
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.89695420
35SPI1_23127762_ChIP-Seq_K562_Human1.89212486
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78939031
37GATA1_19941827_ChIP-Seq_MEL_Mouse1.78000283
38SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.76557034
39GATA1_19941826_ChIP-Seq_K562_Human1.76319003
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.76215098
41FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.75727542
42NANOG_21062744_ChIP-ChIP_HESCs_Human1.71764879
43* KDM2B_26808549_Chip-Seq_JURKAT_Human1.71754667
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.70547034
45ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.70282955
46* UTX_26944678_Chip-Seq_JUKART_Human1.69546635
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.67419333
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67123520
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.66769165
50RACK7_27058665_Chip-Seq_MCF-7_Human1.66516508
51SCL_19346495_ChIP-Seq_HPC-7_Human1.66019350
52MYC_22102868_ChIP-Seq_BL_Human1.65671452
53* LXR_22158963_ChIP-Seq_LIVER_Mouse1.65578045
54TCF3_18692474_ChIP-Seq_MEFs_Mouse1.64482948
55* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.61677136
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.61167895
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.60158625
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58550620
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.57652592
60NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.56860378
61FOXM1_23109430_ChIP-Seq_U2OS_Human1.55114944
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.50978166
63ZFP281_27345836_Chip-Seq_ESCs_Mouse1.50829102
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50636705
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50043488
66RUNX_20019798_ChIP-Seq_JUKART_Human1.49897084
67MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49479693
68* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.49122867
69* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48861300
70* KDM2B_26808549_Chip-Seq_DND41_Human1.48710455
71* MAF_26560356_Chip-Seq_TH2_Human1.48690297
72RXRA_24833708_ChIP-Seq_LIVER_Mouse1.48163614
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47093465
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44928285
75* SA1_27219007_Chip-Seq_ERYTHROID_Human1.43451486
76IRF8_27001747_Chip-Seq_BMDM_Mouse1.43390848
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.42914470
78EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.42547072
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42543985
80SMC4_20622854_ChIP-Seq_HELA_Human1.42535104
81EGR1_19374776_ChIP-ChIP_THP-1_Human1.41997383
82DROSHA_22980978_ChIP-Seq_HELA_Human1.41511624
83MYC_18555785_ChIP-Seq_MESCs_Mouse1.40793150
84* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40535862
85MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40466425
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.40378932
87NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.39856769
88* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37774205
89MYC_19079543_ChIP-ChIP_MESCs_Mouse1.37169899
90POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.37091009
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35202386
92* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33920501
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32571060
94DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29441600
95RARB_24833708_ChIP-Seq_LIVER_Mouse1.29336584
96NANOG_18692474_ChIP-Seq_MESCs_Mouse1.28201010
97SOX2_18692474_ChIP-Seq_MESCs_Mouse1.28162484
98SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27146839
99GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25935594
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25464301
101NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25263581
102RARA_24833708_ChIP-Seq_LIVER_Mouse1.24651538
103CTCF_21964334_ChIP-Seq_BJAB-B_Human1.24101728
104NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23868569
105PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.23024413
106MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22713054
107TP63_17297297_ChIP-ChIP_HaCaT_Human1.21608017
108IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21306053
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20395949
110NCOR1_26117541_ChIP-Seq_K562_Human1.20098375
111NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.19895297
112MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19534809
113* ETS1_21867929_ChIP-Seq_TH2_Mouse1.19152809
114ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18828845
115* BCOR_27268052_Chip-Seq_Bcells_Human1.18246306
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18208841
117* ELK3_25401928_ChIP-Seq_HUVEC_Human1.17780438
118UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17413147
119GATA2_19941826_ChIP-Seq_K562_Human1.17402327
120FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.17102155
121TBX20_22328084_ChIP-Seq_HEART_Mouse1.16705204
122TBX20_22080862_ChIP-Seq_HEART_Mouse1.16705204
123SOX2_18692474_ChIP-Seq_MEFs_Mouse1.15829349
124ELF1_20517297_ChIP-Seq_JURKAT_Human1.15101112
125P68_20966046_ChIP-Seq_HELA_Human1.15042495
126BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14498414
127* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14468086
128TCF7_22412390_ChIP-Seq_EML_Mouse1.13970714
129PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13901087
130E2F1_20622854_ChIP-Seq_HELA_Human1.13740561
131SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12463063
132* PHF8_20622854_ChIP-Seq_HELA_Human1.11689148
133STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11309104
134* KDM2B_26808549_Chip-Seq_K562_Human1.11054860
135IRF8_21731497_ChIP-ChIP_J774_Mouse1.10511986
136CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10424572
137RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09735440
138* SPI1_26923725_Chip-Seq_HPCs_Mouse1.09570121
139RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09412826
140KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09390440
141* BCL6_27268052_Chip-Seq_Bcells_Human1.09368366
142CREB1_26743006_Chip-Seq_LNCaP_Human1.08593035
143OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06598261
144CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06462560
145IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04937152
146THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04898008
147SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04840088
148* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04752833
149NANOG_16518401_ChIP-PET_MESCs_Mouse1.04567436
150* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04272456
151EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04138175
152* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04091427
153RUNX1_27514584_Chip-Seq_MCF-7_Human1.04083350
154GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03988317
155KAP1_27257070_Chip-Seq_ESCs_Mouse1.03976029
156* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03280419
157PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02972722
158STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02744783
159NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02236165
160SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02090421
161GATA1_22025678_ChIP-Seq_K562_Human1.01741949
162SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01119130
163* CTCF_27219007_Chip-Seq_Bcells_Human1.00931802
164TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00651844
165GATA2_21666600_ChIP-Seq_HMVEC_Human0.99828363
166* MYB_26560356_Chip-Seq_TH1_Human0.99691523
167CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99059289
168TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.98821528
169YY1_22570637_ChIP-Seq_MALME-3M_Human0.98556387
170SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98014689
171POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97456414

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.96094179
2MP0009278_abnormal_bone_marrow4.13006821
3MP0004233_abnormal_muscle_weight3.63480172
4MP0003303_peritoneal_inflammation3.51646282
5MP0005085_abnormal_gallbladder_physiolo3.37480723
6MP0003436_decreased_susceptibility_to3.24281240
7MP0005451_abnormal_body_composition3.23414652
8MP0005365_abnormal_bile_salt3.20934774
9MP0010030_abnormal_orbit_morphology3.12502362
10MP0005171_absent_coat_pigmentation2.95513317
11MP0003724_increased_susceptibility_to2.84946272
12MP0002653_abnormal_ependyma_morphology2.58503419
13MP0003300_gastrointestinal_ulcer2.56662451
14MP0002009_preneoplasia2.47615430
15MP0008260_abnormal_autophagy2.44317575
16MP0003283_abnormal_digestive_organ2.40429472
17MP0002139_abnormal_hepatobiliary_system2.28935993
18MP0003191_abnormal_cellular_cholesterol2.26772027
19MP0005360_urolithiasis2.26749620
20MP0008995_early_reproductive_senescence2.25918035
21MP0003890_abnormal_embryonic-extraembry2.22716752
22MP0004510_myositis2.11367810
23MP0002419_abnormal_innate_immunity2.11350897
24MP0005397_hematopoietic_system_phenotyp2.05964643
25MP0001545_abnormal_hematopoietic_system2.05964643
26MP0001835_abnormal_antigen_presentation2.02386747
27MP0005025_abnormal_response_to2.01633456
28MP0000685_abnormal_immune_system1.97243799
29MP0001790_abnormal_immune_system1.95137038
30MP0005387_immune_system_phenotype1.95137038
31MP0002269_muscular_atrophy1.92510290
32MP0005076_abnormal_cell_differentiation1.91885433
33MP0003119_abnormal_digestive_system1.89999611
34MP0002132_abnormal_respiratory_system1.85250731
35MP0004133_heterotaxia1.82511051
36MP0003705_abnormal_hypodermis_morpholog1.78019310
37MP0005000_abnormal_immune_tolerance1.77172256
38MP0003763_abnormal_thymus_physiology1.75099820
39MP0005464_abnormal_platelet_physiology1.74822904
40MP0001800_abnormal_humoral_immune1.74793230
41MP0003453_abnormal_keratinocyte_physiol1.73165361
42MP0006072_abnormal_retinal_apoptosis1.72890153
43MP0002086_abnormal_extraembryonic_tissu1.65901601
44MP0000579_abnormal_nail_morphology1.65546613
45MP0004947_skin_inflammation1.65474598
46MP0002249_abnormal_larynx_morphology1.64672386
47MP0003806_abnormal_nucleotide_metabolis1.63904010
48MP0005409_darkened_coat_color1.61254232
49MP0001533_abnormal_skeleton_physiology1.61026901
50MP0002420_abnormal_adaptive_immunity1.60474759
51MP0010352_gastrointestinal_tract_polyps1.59438088
52MP0001819_abnormal_immune_cell1.58012419
53MP0010094_abnormal_chromosome_stability1.55539383
54MP0002723_abnormal_immune_serum1.53751528
55MP0002084_abnormal_developmental_patter1.52316211
56MP0002452_abnormal_antigen_presenting1.47141521
57MP0004197_abnormal_fetal_growth/weight/1.45660586
58MP0002282_abnormal_trachea_morphology1.44372737
59MP0001697_abnormal_embryo_size1.44135696
60MP0004381_abnormal_hair_follicle1.43317537
61MP0001293_anophthalmia1.42081282
62MP0008877_abnormal_DNA_methylation1.40461842
63MP0001958_emphysema1.38349048
64MP0004036_abnormal_muscle_relaxation1.37730334
65MP0002796_impaired_skin_barrier1.37364196
66MP0003786_premature_aging1.37249645
67MP0003091_abnormal_cell_migration1.36421100
68MP0010155_abnormal_intestine_physiology1.35411392
69MP0009785_altered_susceptibility_to1.35120498
70MP0002998_abnormal_bone_remodeling1.34745497
71MP0004858_abnormal_nervous_system1.32799408
72MP0006082_CNS_inflammation1.32651524
73MP0003566_abnormal_cell_adhesion1.32447387
74MP0004019_abnormal_vitamin_homeostasis1.32303952
75MP0004957_abnormal_blastocyst_morpholog1.31798021
76MP0002085_abnormal_embryonic_tissue1.30770213
77MP0003172_abnormal_lysosome_physiology1.30736528
78MP0004264_abnormal_extraembryonic_tissu1.30698906
79MP0009840_abnormal_foam_cell1.30646283
80MP0002405_respiratory_system_inflammati1.30304091
81MP0000747_muscle_weakness1.30018516
82MP0002398_abnormal_bone_marrow1.29887327
83MP0005380_embryogenesis_phenotype1.28769346
84MP0001672_abnormal_embryogenesis/_devel1.28769346
85MP0003075_altered_response_to1.27825272
86MP0003567_abnormal_fetal_cardiomyocyte1.26900932
87MP0001849_ear_inflammation1.26416709
88MP0000639_abnormal_adrenal_gland1.26263079
89MP0003656_abnormal_erythrocyte_physiolo1.25507506
90MP0005666_abnormal_adipose_tissue1.24902126
91MP0005058_abnormal_lysosome_morphology1.24142540
92MP0003183_abnormal_peptide_metabolism1.22007447
93MP0000678_abnormal_parathyroid_gland1.21804508
94MP0003690_abnormal_glial_cell1.21349678
95MP0000749_muscle_degeneration1.20060004
96MP0000716_abnormal_immune_system1.19699701
97MP0005266_abnormal_metabolism1.19002588
98MP0003329_amyloid_beta_deposits1.18303825
99MP0000371_diluted_coat_color1.18191043
100MP0005671_abnormal_response_to1.17837108
101MP0008004_abnormal_stomach_pH1.17588815
102MP0001851_eye_inflammation1.16990385
103MP0003879_abnormal_hair_cell1.16877301
104MP0003111_abnormal_nucleus_morphology1.16872634
105MP0000759_abnormal_skeletal_muscle1.16640747
106MP0002396_abnormal_hematopoietic_system1.15578758
107MP0000858_altered_metastatic_potential1.14654221
108MP0005166_decreased_susceptibility_to1.14175009
109MP0003279_aneurysm1.12631910
110MP0003866_abnormal_defecation1.10368957
111MP0005330_cardiomyopathy1.10299177
112MP0001730_embryonic_growth_arrest1.07907971
113MP0009333_abnormal_splenocyte_physiolog1.07291936
114MP0008875_abnormal_xenobiotic_pharmacok1.05594715
115MP0000462_abnormal_digestive_system1.05129541
116MP0010630_abnormal_cardiac_muscle1.04679437
117MP0000703_abnormal_thymus_morphology1.03784331
118MP0003045_fibrosis1.02083715
119MP0002722_abnormal_immune_system1.01904848
120MP0000609_abnormal_liver_physiology1.01203900
121MP0003984_embryonic_growth_retardation1.01072192
122MP0004130_abnormal_muscle_cell1.00077037
123MP0005375_adipose_tissue_phenotype0.99907126
124MP0010329_abnormal_lipoprotein_level0.99662211
125MP0001845_abnormal_inflammatory_respons0.99465945
126MP0002148_abnormal_hypersensitivity_rea0.98863158
127MP0005410_abnormal_fertilization0.98244060
128MP0002088_abnormal_embryonic_growth/wei0.97541122
129MP0002332_abnormal_exercise_endurance0.97506456
130MP0004185_abnormal_adipocyte_glucose0.96663098
131MP0005174_abnormal_tail_pigmentation0.96415469
132MP0008874_decreased_physiological_sensi0.95850672
133MP0003252_abnormal_bile_duct0.95777767
134MP0001348_abnormal_lacrimal_gland0.95532379
135MP0005377_hearing/vestibular/ear_phenot0.95341429
136MP0003878_abnormal_ear_physiology0.95341429
137MP0002429_abnormal_blood_cell0.95318338
138MP0003137_abnormal_impulse_conducting0.95086127
139MP0005332_abnormal_amino_acid0.93337196
140MP0000465_gastrointestinal_hemorrhage0.92964167
141MP0006138_congestive_heart_failure0.92739935
142MP0005075_abnormal_melanosome_morpholog0.92372450
143MP0001340_abnormal_eyelid_morphology0.92095507
144MP0000470_abnormal_stomach_morphology0.92045837
145MP0000350_abnormal_cell_proliferation0.91057365
146MP0000751_myopathy0.89959509
147MP0000689_abnormal_spleen_morphology0.88937848
148MP0004883_abnormal_blood_vessel0.88817452
149MP0004084_abnormal_cardiac_muscle0.88026415
150* MP0002080_prenatal_lethality0.87205658
151MP0003646_muscle_fatigue0.86931386
152MP0000604_amyloidosis0.86676266
153MP0002111_abnormal_tail_morphology0.85254839
154MP0001324_abnormal_eye_pigmentation0.84852339
155MP0005319_abnormal_enzyme/_coenzyme0.84422659
156MP0009053_abnormal_anal_canal0.84071581
157MP0000343_altered_response_to0.83747415
158MP0003718_maternal_effect0.82915804
159MP0002106_abnormal_muscle_physiology0.81350505
160MP0002118_abnormal_lipid_homeostasis0.80807646
161MP0000490_abnormal_crypts_of0.79684325
162MP0008058_abnormal_DNA_repair0.79473795
163MP0001929_abnormal_gametogenesis0.78839739
164MP0002971_abnormal_brown_adipose0.78647131
165MP0002970_abnormal_white_adipose0.78526398
166MP0001145_abnormal_male_reproductive0.77806208
167MP0003828_pulmonary_edema0.77762185
168MP0004087_abnormal_muscle_fiber0.77388985
169MP0005501_abnormal_skin_physiology0.76284860
170MP0010307_abnormal_tumor_latency0.73629496
171MP0002932_abnormal_joint_morphology0.73492355
172MP0001666_abnormal_nutrient_absorption0.73110992
173MP0005083_abnormal_biliary_tract0.72532845
174MP0002060_abnormal_skin_morphology0.72494264
175MP0008932_abnormal_embryonic_tissue0.72445380
176MP0002019_abnormal_tumor_incidence0.71517282
177MP0003077_abnormal_cell_cycle0.71273772
178MP0003935_abnormal_craniofacial_develop0.69763121

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)5.49817405
2Rib fusion (HP:0000902)5.03522602
3Turricephaly (HP:0000262)4.81176383
4Alopecia of scalp (HP:0002293)4.76746180
5Annular pancreas (HP:0001734)4.64788655
6Eczematoid dermatitis (HP:0000976)4.51456323
7Facial hemangioma (HP:0000329)4.47634762
8Pustule (HP:0200039)4.45783717
9Concave nail (HP:0001598)4.37563488
10Male infertility (HP:0003251)4.28118321
11Rectal fistula (HP:0100590)4.15341094
12Rectovaginal fistula (HP:0000143)4.15341094
13Ulnar bowing (HP:0003031)4.11080526
14Intestinal fistula (HP:0100819)3.91876013
15Vaginal fistula (HP:0004320)3.88804749
16Short humerus (HP:0005792)3.69436271
17Poikiloderma (HP:0001029)3.67252203
18Increased IgM level (HP:0003496)3.64542619
19Coronal craniosynostosis (HP:0004440)3.50527088
20Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.46756470
21Tongue fasciculations (HP:0001308)3.46269004
22Aplasia/hypoplasia of the humerus (HP:0006507)3.43728911
23Muscle fibrillation (HP:0010546)3.38071329
24Recurrent abscess formation (HP:0002722)3.36762083
25Abnormality of the lower motor neuron (HP:0002366)3.30609935
26Recurrent bacterial skin infections (HP:0005406)3.24912545
27Obstructive sleep apnea (HP:0002870)3.21501866
28Polycythemia (HP:0001901)3.19339319
29Increased variability in muscle fiber diameter (HP:0003557)3.14181408
30Centrally nucleated skeletal muscle fibers (HP:0003687)3.13951065
31Abnormality of macrophages (HP:0004311)3.11949175
32Abnormal hemoglobin (HP:0011902)3.11329314
33Pancreatic islet-cell hyperplasia (HP:0004510)3.07034330
34Myositis (HP:0100614)3.06296216
35Abnormality of skeletal muscle fiber size (HP:0012084)3.06085017
36Orthostatic hypotension (HP:0001278)3.05785124
37Spontaneous hematomas (HP:0007420)3.05663487
38Increased connective tissue (HP:0009025)3.01225205
39Muscle fiber splitting (HP:0003555)2.98624271
40Increased IgE level (HP:0003212)2.98233932
41Large for gestational age (HP:0001520)2.94070473
42Diaphragmatic weakness (HP:0009113)2.90629859
43Congenital hip dislocation (HP:0001374)2.90280105
44Recurrent gram-negative bacterial infections (HP:0005420)2.85194931
45Mucopolysacchariduria (HP:0008155)2.84119502
46Urinary glycosaminoglycan excretion (HP:0003541)2.84119502
47Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.82517549
48Vertebral hypoplasia (HP:0008417)2.82517549
49Hypobetalipoproteinemia (HP:0003563)2.79735442
50Cellulitis (HP:0100658)2.78243290
51Difficulty running (HP:0009046)2.77005297
52Hypochromic anemia (HP:0001931)2.76918434
53Abnormality of the aortic arch (HP:0012303)2.76481048
54Hyporeflexia of lower limbs (HP:0002600)2.76063766
55Dysautonomia (HP:0002459)2.75790190
56Cerebral aneurysm (HP:0004944)2.73763597
57Broad alveolar ridges (HP:0000187)2.72842204
58Asymmetric septal hypertrophy (HP:0001670)2.70960509
59Exercise-induced myalgia (HP:0003738)2.70484441
60Anteriorly placed anus (HP:0001545)2.70285493
61Type 1 muscle fiber predominance (HP:0003803)2.70181536
62Orchitis (HP:0100796)2.68814770
63Short chin (HP:0000331)2.64902862
64Intestinal atresia (HP:0011100)2.63632638
65Gingivitis (HP:0000230)2.62568030
66Gastrointestinal infarctions (HP:0005244)2.61682170
67Abnormality of male internal genitalia (HP:0000022)2.61156702
68Squamous cell carcinoma (HP:0002860)2.60823084
69Hamartoma (HP:0010566)2.58014542
70Distal lower limb muscle weakness (HP:0009053)2.57203629
71Abnormality of mucopolysaccharide metabolism (HP:0011020)2.55134928
72Abnormality of polysaccharide metabolism (HP:0011012)2.55134928
73Abnormality of glycosaminoglycan metabolism (HP:0004371)2.55134928
74Nasal polyposis (HP:0100582)2.53149987
75Absent radius (HP:0003974)2.52665403
76Chronic obstructive pulmonary disease (HP:0006510)2.52487488
77Obstructive lung disease (HP:0006536)2.52487488
78Growth hormone excess (HP:0000845)2.52031502
79Prolonged bleeding time (HP:0003010)2.51628962
80Myopathic facies (HP:0002058)2.51450814
81Premature skin wrinkling (HP:0100678)2.51281452
82Abnormality of the nasal mucosa (HP:0000433)2.50624911
83Albinism (HP:0001022)2.47501702
84Alacrima (HP:0000522)2.43508522
85Basal cell carcinoma (HP:0002671)2.42476478
86Hypotrichosis (HP:0001006)2.42037129
87Intrahepatic cholestasis (HP:0001406)2.40187729
88Gastrointestinal inflammation (HP:0004386)2.39242037
89Clumsiness (HP:0002312)2.35000753
90Muscle fiber inclusion bodies (HP:0100299)2.34913239
91Aplasia involving forearm bones (HP:0009822)2.34383046
92Absent forearm bone (HP:0003953)2.34383046
93Colitis (HP:0002583)2.33917626
94Abnormality of the astrocytes (HP:0100707)2.33517876
95Astrocytoma (HP:0009592)2.33517876
96Abnormality of aromatic amino acid family metabolism (HP:0004338)2.31092202
97Choanal stenosis (HP:0000452)2.31010288
98Inflammation of the large intestine (HP:0002037)2.30627477
99Dysostosis multiplex (HP:0000943)2.30407739
100Abnormality of the fingertips (HP:0001211)2.28022001
101Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.26869692
102Meningitis (HP:0001287)2.26721275
103Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.25914241
104Bowed forearm bones (HP:0003956)2.22400826
105Bowing of the arm (HP:0006488)2.22400826
106Abnormality of endocrine pancreas physiology (HP:0012093)2.21643313
107Abnormality of the pancreatic islet cells (HP:0006476)2.21643313
108Lower limb hyperreflexia (HP:0002395)2.20765599
109Distal lower limb amyotrophy (HP:0008944)2.20588705
110Retrobulbar optic neuritis (HP:0100654)2.19674767
111Optic neuritis (HP:0100653)2.19674767
112Vertebral fusion (HP:0002948)2.17021017
113Myocardial infarction (HP:0001658)2.16982097
114Absent thumb (HP:0009777)2.16550593
115Nemaline bodies (HP:0003798)2.15533162
116Abnormality of monocarboxylic acid metabolism (HP:0010996)2.15122066
117Chest pain (HP:0100749)2.14821257
118Mediastinal lymphadenopathy (HP:0100721)2.12150938
119Recurrent fungal infections (HP:0002841)2.11265361
120Bulbar palsy (HP:0001283)2.11056425
121Aplasia of the musculature (HP:0100854)2.10130078
122EMG: myopathic abnormalities (HP:0003458)2.09794495
123Hypokinesia (HP:0002375)2.08699497
124Ketoacidosis (HP:0001993)2.07993337
125Elevated erythrocyte sedimentation rate (HP:0003565)2.07899464
126Volvulus (HP:0002580)2.07401069
127Infertility (HP:0000789)2.05842139
128Split hand (HP:0001171)2.04157066
129Joint stiffness (HP:0001387)2.03591966
130Peritonitis (HP:0002586)2.02468700
131Recurrent skin infections (HP:0001581)2.02460049
132Selective tooth agenesis (HP:0001592)2.02398023
133Ventricular fibrillation (HP:0001663)2.02339696
134Epistaxis (HP:0000421)2.02222828
135Slow saccadic eye movements (HP:0000514)2.01936145
136Hypercortisolism (HP:0001578)2.01851111
137Easy fatigability (HP:0003388)1.99742004
138Hypotelorism (HP:0000601)1.99395668
139Metaphyseal cupping (HP:0003021)1.96576706
140Hyperammonemia (HP:0001987)1.95903525
141Deep venous thrombosis (HP:0002625)1.95782986
142Segmental peripheral demyelination/remyelination (HP:0003481)1.94304659
143Patellar aplasia (HP:0006443)1.94229224
144Vasculitis (HP:0002633)1.92857898
145Ketosis (HP:0001946)1.92579743
146Abnormal delayed hypersensitivity skin test (HP:0002963)1.92546927
147Abnormality of the labia minora (HP:0012880)1.92350590
148Ventricular tachycardia (HP:0004756)1.92267488
149Hyperglycinuria (HP:0003108)1.91273443
150Malnutrition (HP:0004395)1.90546700
151Urticaria (HP:0001025)1.89298580
152Heterotopia (HP:0002282)1.88780127
153EMG: neuropathic changes (HP:0003445)1.88504978
154Aneurysm (HP:0002617)1.88254936
155Hypolipoproteinemia (HP:0010981)1.88175800
156Neoplasm of the oral cavity (HP:0100649)1.87462745
157Generalized amyotrophy (HP:0003700)1.87146458
158Gastrointestinal stroma tumor (HP:0100723)1.85575715
159Capillary hemangiomas (HP:0005306)1.84793888
160Gingival bleeding (HP:0000225)1.83288201
161Purpura (HP:0000979)1.82045642
162Hemorrhage of the eye (HP:0011885)1.81965850
163Sudden death (HP:0001699)1.81574978
164Microcytic anemia (HP:0001935)1.80620691
165Amyloidosis (HP:0011034)1.80403270
166Supranuclear gaze palsy (HP:0000605)1.80015282
167Emphysema (HP:0002097)1.79440776
168Subaortic stenosis (HP:0001682)1.79324406
169Abnormality of the left ventricular outflow tract (HP:0011103)1.79324406
170Broad face (HP:0000283)1.79101034
171Difficulty climbing stairs (HP:0003551)1.78687521
172Interstitial pulmonary disease (HP:0006530)1.78402037
173Foot dorsiflexor weakness (HP:0009027)1.77766246
174Dysmetric saccades (HP:0000641)1.77237872
175Ulnar deviation of the wrist (HP:0003049)1.76228330
176Dilatation of the ascending aorta (HP:0005111)1.74498552
177Ankle clonus (HP:0011448)1.74463728
178Osteomyelitis (HP:0002754)1.71375545
179Keratoconjunctivitis sicca (HP:0001097)1.70389844
180Onion bulb formation (HP:0003383)1.69905900
181Papilledema (HP:0001085)1.68950614
182Abnormality of the heme biosynthetic pathway (HP:0010472)1.67904891
183Restrictive lung disease (HP:0002091)1.67462833
184Reticulocytosis (HP:0001923)1.67422858
185Protrusio acetabuli (HP:0003179)1.66275698
186Aortic aneurysm (HP:0004942)1.65931656
187Polygenic inheritance (HP:0010982)1.64913951
188Round ear (HP:0100830)1.64862664
189Hypertriglyceridemia (HP:0002155)1.62409928
190Abnormality of binocular vision (HP:0011514)1.62146896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.48583268
2DDR24.62739604
3MAP3K64.17788109
4MAPK154.08436612
5PINK13.41477018
6RIPK43.40355258
7TYRO33.16898065
8MAP3K113.11333261
9MATK2.66367102
10MAP2K32.56040757
11FGR2.53802988
12MAP4K12.28732333
13BMX2.23759134
14PDGFRA2.17093140
15PRKD22.14286050
16DAPK12.09846355
17DYRK1B2.06879162
18SMG12.03896964
19UHMK11.95426227
20CSK1.90677952
21LATS21.90133426
22EPHB11.84862036
23TYK21.79442648
24TNK21.72105679
25MAP3K31.63810308
26KSR21.61534697
27BLK1.60664279
28AKT31.56266185
29EEF2K1.54548329
30MAP3K131.51419761
31ZAP701.49519848
32PIM21.46633863
33TRIB31.46539584
34CDK71.46033907
35PHKG21.45636985
36PHKG11.45636985
37CDK121.44808301
38IRAK41.44762653
39MAP3K101.44420570
40YES11.43715235
41CDK61.42959021
42MAP3K11.40520852
43FES1.38900305
44GRK61.34389840
45MAPK121.27438422
46MAP3K71.24559192
47MAPK111.21907623
48PIM11.17183832
49FGFR41.15393295
50TRPM71.14436782
51CDC42BPA1.10442784
52RPS6KL11.09773495
53RPS6KC11.09773495
54SIK21.09739785
55PDPK11.09656679
56BTK1.08611270
57PTK61.07075261
58TBK11.06555547
59HCK1.05802690
60GSK3A1.04999001
61MTOR1.00806080
62JAK31.00289367
63OBSCN0.99208000
64LATS10.97457531
65PRKAA10.95438458
66RPS6KA60.93787410
67PDK10.93256915
68SGK30.92481702
69CHEK20.91513480
70JAK10.91241903
71PDK40.88440284
72PDK30.88440284
73SYK0.83705803
74STK380.83384806
75RPS6KA20.80837545
76RET0.80403204
77CAMKK10.74837635
78LRRK20.74517928
79NEK10.74451426
80PRKD30.74301205
81SIK30.73260437
82BCKDK0.73185737
83FGFR30.72915306
84MAP3K90.71722885
85MAPK70.71514645
86DYRK30.70960089
87MAP3K20.70913197
88RPS6KA10.70856465
89RIPK10.69996010
90TAOK20.68906184
91TAOK10.68588969
92MARK30.68252169
93NEK20.67531309
94PLK10.65813651
95PRPF4B0.63925224
96SIK10.62016110
97IKBKE0.61928973
98MAP3K140.60928503
99HIPK20.60828212
100EPHA20.60080604
101SGK20.56818266
102STK30.55593600
103IRAK30.54589487
104IRAK20.53960471
105STK38L0.52780411
106SGK4940.51337285
107SGK2230.51337285
108PRKAA20.50604991
109PIK3CG0.49210958
110ITK0.48780426
111LYN0.48589627
112PDGFRB0.48063895
113PRKCH0.48056123
114STK110.47478543
115CSF1R0.46268876
116LCK0.46201596
117PRKG20.45940367
118FYN0.45621379
119CDK20.45446078
120PTK2B0.45273402
121ALK0.44926118
122RPS6KB20.43194165
123MAP2K40.42901420
124CAMK40.42837765
125EGFR0.42754166
126RAF10.42316574
127TGFBR20.41521503
128TESK10.40940518
129ERN10.40817278
130KIT0.40421517
131PDK20.39250728
132CAMK1D0.39046016
133WNK10.38553491
134PTK20.38471975
135RPS6KB10.37760708
136CDK40.37185641
137MAPK10.36255812
138PKN20.33366045
139MAPK100.33024574
140CAMK2G0.32057888
141PRKCZ0.31302449
142ATR0.31138057
143PAK60.30711989
144CHEK10.30530406
145MAPK40.30110635
146MAPK30.29269204
147MAPKAPK30.28703324
148PRKD10.27479871
149MAPK140.26796006
150PAK20.26356908
151CSNK2A10.25049275
152MARK20.23829701
153RPS6KA30.23793705
154ATM0.23231688
155DMPK0.22660011
156AURKA0.22332009
157CSNK1G10.21804225
158SGK10.21450810
159PRKACG0.20192732
160CDK10.20032476
161TTK0.18881955
162JAK20.17919032
163GSK3B0.17405868
164TTN0.16991680
165INSR0.16774574

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.42746912
2Base excision repair_Homo sapiens_hsa034102.83431596
3Mismatch repair_Homo sapiens_hsa034302.78772005
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.74282466
5Arginine biosynthesis_Homo sapiens_hsa002202.67536282
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.49297111
7Fatty acid metabolism_Homo sapiens_hsa012122.41848233
8Biosynthesis of amino acids_Homo sapiens_hsa012302.31412476
9Arginine and proline metabolism_Homo sapiens_hsa003302.10079418
10Nitrogen metabolism_Homo sapiens_hsa009102.06662317
11B cell receptor signaling pathway_Homo sapiens_hsa046622.05480123
12Osteoclast differentiation_Homo sapiens_hsa043802.02597430
13mTOR signaling pathway_Homo sapiens_hsa041502.02481127
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.99885073
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.91863766
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.89831448
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.85849749
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.78502417
19Lysine degradation_Homo sapiens_hsa003101.78227180
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.78020364
21Leishmaniasis_Homo sapiens_hsa051401.74018899
22DNA replication_Homo sapiens_hsa030301.69127066
23Circadian rhythm_Homo sapiens_hsa047101.66387381
24Sulfur relay system_Homo sapiens_hsa041221.65020512
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.60230573
26Non-small cell lung cancer_Homo sapiens_hsa052231.58881639
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.56092606
28Notch signaling pathway_Homo sapiens_hsa043301.54904462
29Folate biosynthesis_Homo sapiens_hsa007901.54680832
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53009672
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.51726178
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.47784973
33Other glycan degradation_Homo sapiens_hsa005111.45212863
34Hedgehog signaling pathway_Homo sapiens_hsa043401.43123588
35Staphylococcus aureus infection_Homo sapiens_hsa051501.41697744
36Longevity regulating pathway - mammal_Homo sapiens_hsa042111.39792773
37Hippo signaling pathway_Homo sapiens_hsa043901.38179213
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35809885
39Fructose and mannose metabolism_Homo sapiens_hsa000511.33388535
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31116780
41Tuberculosis_Homo sapiens_hsa051521.30247053
42mRNA surveillance pathway_Homo sapiens_hsa030151.29956809
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27872287
44Adherens junction_Homo sapiens_hsa045201.27004359
45Neurotrophin signaling pathway_Homo sapiens_hsa047221.25995615
46Malaria_Homo sapiens_hsa051441.24943470
47T cell receptor signaling pathway_Homo sapiens_hsa046601.24942983
48GnRH signaling pathway_Homo sapiens_hsa049121.24835002
49Pancreatic cancer_Homo sapiens_hsa052121.24831140
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.21593444
51Tryptophan metabolism_Homo sapiens_hsa003801.20318015
52Renal cell carcinoma_Homo sapiens_hsa052111.20193103
53Endometrial cancer_Homo sapiens_hsa052131.19714097
54Fatty acid degradation_Homo sapiens_hsa000711.18079372
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16853272
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16696076
57Maturity onset diabetes of the young_Homo sapiens_hsa049501.16669180
58Chemokine signaling pathway_Homo sapiens_hsa040621.16502376
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13173729
60Toxoplasmosis_Homo sapiens_hsa051451.12885020
61Phospholipase D signaling pathway_Homo sapiens_hsa040721.12594202
62Platelet activation_Homo sapiens_hsa046111.11567097
63RNA transport_Homo sapiens_hsa030131.10608133
64Bladder cancer_Homo sapiens_hsa052191.09371792
65Selenocompound metabolism_Homo sapiens_hsa004501.08370569
66Long-term potentiation_Homo sapiens_hsa047201.08133187
67Adipocytokine signaling pathway_Homo sapiens_hsa049201.07050740
68Propanoate metabolism_Homo sapiens_hsa006401.05526687
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01934908
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01337773
71Inositol phosphate metabolism_Homo sapiens_hsa005621.00685751
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00337810
73Glioma_Homo sapiens_hsa052140.99778330
74Insulin resistance_Homo sapiens_hsa049310.99579110
75Influenza A_Homo sapiens_hsa051640.98639307
76Fat digestion and absorption_Homo sapiens_hsa049750.98615404
77Hepatitis C_Homo sapiens_hsa051600.98506473
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97989964
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97957121
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97713259
81Amoebiasis_Homo sapiens_hsa051460.96096635
82Prolactin signaling pathway_Homo sapiens_hsa049170.95826408
83PPAR signaling pathway_Homo sapiens_hsa033200.95270656
84Measles_Homo sapiens_hsa051620.94281693
85Viral myocarditis_Homo sapiens_hsa054160.94094624
86Carbon metabolism_Homo sapiens_hsa012000.93636671
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.93617857
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.92171363
89Estrogen signaling pathway_Homo sapiens_hsa049150.91639227
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91416241
91TNF signaling pathway_Homo sapiens_hsa046680.89763803
92Hepatitis B_Homo sapiens_hsa051610.89189008
93p53 signaling pathway_Homo sapiens_hsa041150.89079745
94Dorso-ventral axis formation_Homo sapiens_hsa043200.88171549
95Pyruvate metabolism_Homo sapiens_hsa006200.87910133
96AMPK signaling pathway_Homo sapiens_hsa041520.87868012
97Endocytosis_Homo sapiens_hsa041440.86576074
98Nucleotide excision repair_Homo sapiens_hsa034200.85194103
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.83944129
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.83204447
101VEGF signaling pathway_Homo sapiens_hsa043700.82648584
102Allograft rejection_Homo sapiens_hsa053300.82334546
103Graft-versus-host disease_Homo sapiens_hsa053320.81408232
104Autoimmune thyroid disease_Homo sapiens_hsa053200.79594479
105Focal adhesion_Homo sapiens_hsa045100.79015535
106Bile secretion_Homo sapiens_hsa049760.78645309
107TGF-beta signaling pathway_Homo sapiens_hsa043500.78092793
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.77986171
109Dilated cardiomyopathy_Homo sapiens_hsa054140.77877859
110Glycerolipid metabolism_Homo sapiens_hsa005610.77625885
111FoxO signaling pathway_Homo sapiens_hsa040680.77476865
112Starch and sucrose metabolism_Homo sapiens_hsa005000.77117112
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76483560
114Galactose metabolism_Homo sapiens_hsa000520.76074563
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75596530
116Insulin signaling pathway_Homo sapiens_hsa049100.74765760
117Type II diabetes mellitus_Homo sapiens_hsa049300.74202906
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73647087
119Apoptosis_Homo sapiens_hsa042100.73501470
120MAPK signaling pathway_Homo sapiens_hsa040100.73402412
121Basal cell carcinoma_Homo sapiens_hsa052170.73243653
122Vitamin B6 metabolism_Homo sapiens_hsa007500.73242497
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73171112
124Oxytocin signaling pathway_Homo sapiens_hsa049210.72537859
125Phagosome_Homo sapiens_hsa041450.72181097
126Prion diseases_Homo sapiens_hsa050200.72130106
127Primary immunodeficiency_Homo sapiens_hsa053400.70858735
128Hematopoietic cell lineage_Homo sapiens_hsa046400.70002222
129Complement and coagulation cascades_Homo sapiens_hsa046100.69135181
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68997395
131Gastric acid secretion_Homo sapiens_hsa049710.68435725
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67598202
133Thyroid cancer_Homo sapiens_hsa052160.65917371
134Colorectal cancer_Homo sapiens_hsa052100.65521217
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65015368
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64993650
137Wnt signaling pathway_Homo sapiens_hsa043100.64293909
138Prostate cancer_Homo sapiens_hsa052150.64187311
139Oocyte meiosis_Homo sapiens_hsa041140.64137979
140Pertussis_Homo sapiens_hsa051330.63460296
141HIF-1 signaling pathway_Homo sapiens_hsa040660.63147156
142Rap1 signaling pathway_Homo sapiens_hsa040150.63051246
143NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62998178
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.62947295
145ABC transporters_Homo sapiens_hsa020100.62283766
146RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62258295
147Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61628604
148Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60709109
149Glycerophospholipid metabolism_Homo sapiens_hsa005640.60261954
150Herpes simplex infection_Homo sapiens_hsa051680.59432573
151Spliceosome_Homo sapiens_hsa030400.58568685
152African trypanosomiasis_Homo sapiens_hsa051430.58218873
153Fanconi anemia pathway_Homo sapiens_hsa034600.57589273
154Butanoate metabolism_Homo sapiens_hsa006500.57394056
155Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56828603
156Glucagon signaling pathway_Homo sapiens_hsa049220.55496588
157Drug metabolism - other enzymes_Homo sapiens_hsa009830.54912812
158Glutathione metabolism_Homo sapiens_hsa004800.54277071
159Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53350497
160Tight junction_Homo sapiens_hsa045300.51605323
161beta-Alanine metabolism_Homo sapiens_hsa004100.51173235
162Cyanoamino acid metabolism_Homo sapiens_hsa004600.49841242
163Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49340559
164Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47686726
165Choline metabolism in cancer_Homo sapiens_hsa052310.44996805
166Peroxisome_Homo sapiens_hsa041460.44438306
167Cell cycle_Homo sapiens_hsa041100.43676344
168One carbon pool by folate_Homo sapiens_hsa006700.42756872
169Glycosaminoglycan degradation_Homo sapiens_hsa005310.42281778
170Fatty acid elongation_Homo sapiens_hsa000620.41224777
171Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39064187
172Shigellosis_Homo sapiens_hsa051310.38285028
173Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37784641
174MicroRNAs in cancer_Homo sapiens_hsa052060.36907122
175Acute myeloid leukemia_Homo sapiens_hsa052210.36830374
176Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36812124
177Steroid biosynthesis_Homo sapiens_hsa001000.35959395
178Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35698145
179Homologous recombination_Homo sapiens_hsa034400.35041808
180Chronic myeloid leukemia_Homo sapiens_hsa052200.34699966
181Pentose phosphate pathway_Homo sapiens_hsa000300.34361619
182ErbB signaling pathway_Homo sapiens_hsa040120.33846452
183Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33520155
184Chemical carcinogenesis_Homo sapiens_hsa052040.32590228

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