WEE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.49057791
2DNA strand elongation involved in DNA replication (GO:0006271)5.33114018
3DNA replication initiation (GO:0006270)5.16736190
4telomere maintenance via semi-conservative replication (GO:0032201)5.15117647
5DNA strand elongation (GO:0022616)5.07338254
6protein localization to kinetochore (GO:0034501)4.78633586
7telomere maintenance via recombination (GO:0000722)4.64974626
8DNA replication checkpoint (GO:0000076)4.55872297
9regulation of centriole replication (GO:0046599)4.51431921
10mitotic recombination (GO:0006312)4.47828574
11nuclear pore organization (GO:0006999)4.20814186
12telomere maintenance via telomere lengthening (GO:0010833)4.11871652
13nucleobase biosynthetic process (GO:0046112)4.11128380
14protein localization to chromosome, centromeric region (GO:0071459)4.05269965
15ribosomal small subunit assembly (GO:0000028)4.04887722
16mitotic metaphase plate congression (GO:0007080)3.98281879
17mitotic nuclear envelope disassembly (GO:0007077)3.96522919
18chromatin remodeling at centromere (GO:0031055)3.96023382
19maturation of SSU-rRNA (GO:0030490)3.92620713
20nuclear pore complex assembly (GO:0051292)3.92618204
21CENP-A containing nucleosome assembly (GO:0034080)3.90483332
22IMP biosynthetic process (GO:0006188)3.87335389
23attachment of spindle microtubules to kinetochore (GO:0008608)3.86836051
24regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.84907581
25kinetochore organization (GO:0051383)3.80707528
26nucleotide-excision repair, DNA gap filling (GO:0006297)3.80471457
27mitotic chromosome condensation (GO:0007076)3.79788300
28DNA replication-dependent nucleosome assembly (GO:0006335)3.79193434
29DNA replication-dependent nucleosome organization (GO:0034723)3.79193434
30purine nucleobase biosynthetic process (GO:0009113)3.71861621
31mitotic sister chromatid cohesion (GO:0007064)3.67452231
32formation of translation preinitiation complex (GO:0001731)3.66186749
33membrane disassembly (GO:0030397)3.64864911
34nuclear envelope disassembly (GO:0051081)3.64864911
35mitotic sister chromatid segregation (GO:0000070)3.64272209
36metaphase plate congression (GO:0051310)3.63774182
37DNA replication-independent nucleosome organization (GO:0034724)3.63748567
38DNA replication-independent nucleosome assembly (GO:0006336)3.63748567
39regulation of centrosome cycle (GO:0046605)3.63491405
40positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.54872038
41translesion synthesis (GO:0019985)3.53780997
42regulation of centrosome duplication (GO:0010824)3.53128799
43regulation of DNA endoreduplication (GO:0032875)3.51919154
44IMP metabolic process (GO:0046040)3.51895977
45DNA duplex unwinding (GO:0032508)3.50248286
46DNA geometric change (GO:0032392)3.49410577
47regulation of nuclear cell cycle DNA replication (GO:0033262)3.48509335
48sister chromatid segregation (GO:0000819)3.45431142
49kinetochore assembly (GO:0051382)3.40482571
50regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.39268658
51DNA deamination (GO:0045006)3.38828792
52meiotic chromosome segregation (GO:0045132)3.37875235
53somatic hypermutation of immunoglobulin genes (GO:0016446)3.36467065
54somatic diversification of immune receptors via somatic mutation (GO:0002566)3.36467065
55histone exchange (GO:0043486)3.36210020
56viral transcription (GO:0019083)3.35626530
57translational termination (GO:0006415)3.35373078
58telomere maintenance (GO:0000723)3.34108525
59telomere organization (GO:0032200)3.32811312
60folic acid-containing compound biosynthetic process (GO:0009396)3.30279480
61regulation of spindle organization (GO:0090224)3.29949673
62DNA double-strand break processing (GO:0000729)3.26156691
63intra-S DNA damage checkpoint (GO:0031573)3.21952405
64negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.21607039
65notochord development (GO:0030903)3.20814795
66chromatin assembly or disassembly (GO:0006333)3.17212609
67negative regulation of chromosome segregation (GO:0051985)3.15526015
68DNA conformation change (GO:0071103)3.12166099
69regulation of helicase activity (GO:0051095)3.11366769
70DNA topological change (GO:0006265)3.10399957
71negative regulation of mitotic sister chromatid separation (GO:2000816)3.09797391
72negative regulation of mitotic sister chromatid segregation (GO:0033048)3.09797391
73negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.09797391
74negative regulation of sister chromatid segregation (GO:0033046)3.09797391
75establishment of chromosome localization (GO:0051303)3.09787382
76regulation of chromosome segregation (GO:0051983)3.09413524
77protein localization to chromosome (GO:0034502)3.08006426
78spindle assembly checkpoint (GO:0071173)3.07440009
79monoubiquitinated protein deubiquitination (GO:0035520)3.07320602
80regulation of histone H3-K9 methylation (GO:0051570)3.06120556
81negative regulation of RNA splicing (GO:0033119)3.04603853
82response to X-ray (GO:0010165)3.04275016
83ribosome biogenesis (GO:0042254)3.04100283
84translational elongation (GO:0006414)3.03895912
85positive regulation of chromosome segregation (GO:0051984)3.03647188
86regulation of mitotic metaphase/anaphase transition (GO:0030071)3.01833587
87mismatch repair (GO:0006298)3.00800752
88mitotic spindle assembly checkpoint (GO:0007094)3.00704454
89maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.99915130
90postreplication repair (GO:0006301)2.99891256
91negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.99547733
92protein K6-linked ubiquitination (GO:0085020)2.99182426
93DNA ligation (GO:0006266)2.99154096
94translational initiation (GO:0006413)2.98953502
95spindle checkpoint (GO:0031577)2.98603427
96nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.98362321
97heterochromatin organization (GO:0070828)2.97432598
98negative regulation of DNA-dependent DNA replication (GO:2000104)2.96937217
99ATP-dependent chromatin remodeling (GO:0043044)2.96013168
100regulation of sister chromatid cohesion (GO:0007063)2.95473339
101dosage compensation (GO:0007549)2.95367937
102regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.94836427
103regulation of double-strand break repair via homologous recombination (GO:0010569)2.94225215
104regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.94094393
105pore complex assembly (GO:0046931)2.91169191
106chromosome segregation (GO:0007059)2.90151976
107regulation of gene silencing by RNA (GO:0060966)2.90099329
108regulation of posttranscriptional gene silencing (GO:0060147)2.90099329
109regulation of gene silencing by miRNA (GO:0060964)2.90099329
110base-excision repair (GO:0006284)2.89805614
111regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.88846527
112regulation of mitotic spindle checkpoint (GO:1903504)2.88846527
113positive regulation of mitotic sister chromatid separation (GO:1901970)2.88404173
114positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.88404173
115positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.88404173
116ribonucleoprotein complex biogenesis (GO:0022613)2.87874148
117mitotic spindle checkpoint (GO:0071174)2.86913421
118regulation of sister chromatid segregation (GO:0033045)2.85856314
119regulation of mitotic sister chromatid separation (GO:0010965)2.85856314
120regulation of mitotic sister chromatid segregation (GO:0033047)2.85856314
121female gonad development (GO:0008585)2.85302580
122cell fate commitment involved in formation of primary germ layer (GO:0060795)2.84783561
123nodal signaling pathway (GO:0038092)2.81672607
124histone H2A acetylation (GO:0043968)2.81663182
125regulation of non-canonical Wnt signaling pathway (GO:2000050)2.78935502
126regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.76054444
127positive regulation of mRNA processing (GO:0050685)2.75857017
128regulation of mRNA 3-end processing (GO:0031440)2.73876385
129synapsis (GO:0007129)2.72336402
130negative regulation of mRNA processing (GO:0050686)2.72260336
131positive regulation of mRNA 3-end processing (GO:0031442)2.70255036
132mitotic G2/M transition checkpoint (GO:0044818)2.69523161
133DNA strand renaturation (GO:0000733)2.66407409
134negative regulation of JUN kinase activity (GO:0043508)2.65240205
135DNA synthesis involved in DNA repair (GO:0000731)2.64658428
136non-recombinational repair (GO:0000726)2.63079269
137double-strand break repair via nonhomologous end joining (GO:0006303)2.63079269
138recombinational repair (GO:0000725)2.61343968
139positive regulation of catenin import into nucleus (GO:0035413)2.60024499

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human4.54752397
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.01623466
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.00212600
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.39199026
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.36765364
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.70998195
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61144408
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.50222884
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.45039261
10AR_21909140_ChIP-Seq_LNCAP_Human2.41514836
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.37605379
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.35077431
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20978863
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.20595008
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.19395069
16FUS_26573619_Chip-Seq_HEK293_Human2.19344660
17XRN2_22483619_ChIP-Seq_HELA_Human2.11601196
18* POU5F1_16153702_ChIP-ChIP_HESCs_Human2.06873630
19EWS_26573619_Chip-Seq_HEK293_Human2.05756662
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03206333
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00690538
22E2F7_22180533_ChIP-Seq_HELA_Human10.7404226
23MYC_22102868_ChIP-Seq_BL_Human1.99955832
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.99715588
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.92138040
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90290018
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.87429982
28VDR_23849224_ChIP-Seq_CD4+_Human1.84652136
29* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83738073
30* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.83467451
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80567038
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79058604
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76296879
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74318665
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72536146
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72505266
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72340540
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70956867
39FOXP3_21729870_ChIP-Seq_TREG_Human1.70520575
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69461024
41ZNF274_21170338_ChIP-Seq_K562_Hela1.67454564
42IRF1_19129219_ChIP-ChIP_H3396_Human1.66533729
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64036434
44CIITA_25753668_ChIP-Seq_RAJI_Human1.61896205
45GABP_19822575_ChIP-Seq_HepG2_Human1.61436125
46TTF2_22483619_ChIP-Seq_HELA_Human1.61261090
47* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61001816
48DCP1A_22483619_ChIP-Seq_HELA_Human1.60586130
49VDR_22108803_ChIP-Seq_LS180_Human1.56459132
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55830982
51* NANOG_16153702_ChIP-ChIP_HESCs_Human1.55290492
52SOX2_16153702_ChIP-ChIP_HESCs_Human1.52563764
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47012304
54* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44803269
55SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43878147
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43823088
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43415295
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37874929
59* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37473586
60KDM5A_27292631_Chip-Seq_BREAST_Human1.36877027
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36500505
62* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36291605
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33804945
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33771045
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31683883
66WT1_19549856_ChIP-ChIP_CCG9911_Human1.30791252
67* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27304392
68* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.26510421
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26350243
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.25744769
71ELK1_19687146_ChIP-ChIP_HELA_Human1.25416030
72VDR_21846776_ChIP-Seq_THP-1_Human1.24294287
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23046585
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22274728
75* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19194087
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18902011
77P300_19829295_ChIP-Seq_ESCs_Human1.18370462
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18225730
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17338124
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15386539
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14654615
82NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14268470
83NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14230200
84FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13800574
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12494658
86SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12436278
87SCL_19346495_ChIP-Seq_HPC-7_Human1.11790888
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09612249
89TFEB_21752829_ChIP-Seq_HELA_Human1.08275930
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.07625150
91HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07538392
92* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07386669
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07105021
94SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06327175
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05791356
96YY1_21170310_ChIP-Seq_MESCs_Mouse1.03927202
97SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02468859
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02326254
99* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02261592
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02184432
101* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01388912
102PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01170337
103TAF15_26573619_Chip-Seq_HEK293_Human1.00174283
104SALL1_21062744_ChIP-ChIP_HESCs_Human0.97716630
105FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97474236
106GBX2_23144817_ChIP-Seq_PC3_Human0.96562932
107* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96106066
108SRF_21415370_ChIP-Seq_HL-1_Mouse0.95966113
109TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95863614
110SPI1_23547873_ChIP-Seq_NB4_Human0.95459349
111KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95450004
112KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95450004
113KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95450004
114ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93960535
115* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.92690818
116* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92583201
117NANOG_21062744_ChIP-ChIP_HESCs_Human0.92537288
118TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92130115
119EZH2_27294783_Chip-Seq_NPCs_Mouse0.91737826
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91157555
121MYB_21317192_ChIP-Seq_ERMYB_Mouse0.90702389
122PIAS1_25552417_ChIP-Seq_VCAP_Human0.89746761
123TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88266905
124* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88204892
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87752243
126* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87414764
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86658374
128TBX3_20139965_ChIP-Seq_MESCs_Mouse0.86459471
129CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.86388652
130PKCTHETA_26484144_Chip-Seq_BREAST_Human0.85747429
131* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85223329
132SOX17_20123909_ChIP-Seq_XEN_Mouse0.85160179
133TP53_16413492_ChIP-PET_HCT116_Human0.84897457
134FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83955584
135BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83312854
136SOX9_26525672_Chip-Seq_HEART_Mouse0.83236959
137NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82940951
138ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81745649
139SMAD3_21741376_ChIP-Seq_EPCs_Human0.81731671
140* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81335292
141* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81215962
142MYB_26560356_Chip-Seq_TH1_Human0.80593291
143* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.80288014
144TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80212497
145TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.79742451
146* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.78676804
147TCF7_22412390_ChIP-Seq_EML_Mouse0.78429274
148GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75384507
149MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.74804359
150* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74334053
151* MAF_26560356_Chip-Seq_TH1_Human0.73528347
152MYC_18940864_ChIP-ChIP_HL60_Human0.73339419
153* CHD1_26751641_Chip-Seq_LNCaP_Human0.73224118

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.73014589
2MP0003693_abnormal_embryo_hatching4.49372968
3MP0008057_abnormal_DNA_replication4.39438231
4MP0004957_abnormal_blastocyst_morpholog4.06599392
5MP0003111_abnormal_nucleus_morphology4.05130304
6MP0003077_abnormal_cell_cycle3.61708118
7MP0002396_abnormal_hematopoietic_system3.25248343
8MP0008058_abnormal_DNA_repair3.08962971
9MP0006292_abnormal_olfactory_placode2.98342588
10MP0008007_abnormal_cellular_replicative2.88374150
11MP0000566_synostosis2.60044810
12MP0003123_paternal_imprinting2.56868070
13MP0008877_abnormal_DNA_methylation2.49860494
14MP0010352_gastrointestinal_tract_polyps2.39538577
15MP0000350_abnormal_cell_proliferation2.12784052
16MP0004808_abnormal_hematopoietic_stem2.10272724
17MP0001730_embryonic_growth_arrest2.09066005
18MP0008932_abnormal_embryonic_tissue2.08429535
19MP0003786_premature_aging1.95856991
20MP0010307_abnormal_tumor_latency1.86750316
21MP0000490_abnormal_crypts_of1.85907317
22MP0006054_spinal_hemorrhage1.82665931
23MP0001545_abnormal_hematopoietic_system1.79890915
24MP0005397_hematopoietic_system_phenotyp1.79890915
25MP0001697_abnormal_embryo_size1.74210397
26MP0001672_abnormal_embryogenesis/_devel1.70755823
27MP0005380_embryogenesis_phenotype1.70755823
28MP0002009_preneoplasia1.67779227
29MP0003984_embryonic_growth_retardation1.60060504
30MP0002697_abnormal_eye_size1.56343573
31MP0002088_abnormal_embryonic_growth/wei1.55804310
32MP0008789_abnormal_olfactory_epithelium1.55103154
33MP0003567_abnormal_fetal_cardiomyocyte1.53857237
34MP0002086_abnormal_extraembryonic_tissu1.52909756
35MP0003755_abnormal_palate_morphology1.51082949
36MP0002080_prenatal_lethality1.51033839
37MP0005076_abnormal_cell_differentiation1.48049266
38MP0001286_abnormal_eye_development1.47645156
39MP0003121_genomic_imprinting1.47514811
40MP0010678_abnormal_skin_adnexa1.47514764
41MP0002085_abnormal_embryonic_tissue1.47395550
42MP0002019_abnormal_tumor_incidence1.45803784
43MP0002233_abnormal_nose_morphology1.44223232
44MP0004197_abnormal_fetal_growth/weight/1.43849702
45MP0002084_abnormal_developmental_patter1.43789214
46MP0000313_abnormal_cell_death1.39589822
47MP0002210_abnormal_sex_determination1.38571852
48MP0000647_abnormal_sebaceous_gland1.38547469
49MP0002282_abnormal_trachea_morphology1.37650325
50MP0003718_maternal_effect1.33892756
51MP0000049_abnormal_middle_ear1.32394703
52MP0003950_abnormal_plasma_membrane1.30377495
53MP0005187_abnormal_penis_morphology1.29136439
54MP0001145_abnormal_male_reproductive1.24682975
55MP0003890_abnormal_embryonic-extraembry1.21062128
56MP0001293_anophthalmia1.20884537
57MP0001929_abnormal_gametogenesis1.20199873
58MP0000613_abnormal_salivary_gland1.19396537
59MP0000427_abnormal_hair_cycle1.19312370
60MP0003943_abnormal_hepatobiliary_system1.17015498
61MP0000516_abnormal_urinary_system1.15051900
62MP0005367_renal/urinary_system_phenotyp1.15051900
63MP0001346_abnormal_lacrimal_gland1.14477004
64MP0000432_abnormal_head_morphology1.13987765
65MP0010030_abnormal_orbit_morphology1.12722669
66MP0005394_taste/olfaction_phenotype1.11353323
67MP0005499_abnormal_olfactory_system1.11353323
68MP0002398_abnormal_bone_marrow1.10965864
69MP0009278_abnormal_bone_marrow1.10588133
70MP0004133_heterotaxia1.08196160
71MP0000703_abnormal_thymus_morphology1.06627220
72MP0000653_abnormal_sex_gland1.05371013
73MP0003315_abnormal_perineum_morphology1.01976904
74MP0009250_abnormal_appendicular_skeleto1.01399843
75MP0002722_abnormal_immune_system1.00529492
76MP0003566_abnormal_cell_adhesion1.00503239
77MP0005174_abnormal_tail_pigmentation1.00006015
78MP0003935_abnormal_craniofacial_develop0.99130283
79MP0003763_abnormal_thymus_physiology0.98292813
80MP0003942_abnormal_urinary_system0.98124783
81MP0000537_abnormal_urethra_morphology0.97772267
82MP0000689_abnormal_spleen_morphology0.96908893
83MP0004264_abnormal_extraembryonic_tissu0.96591035
84MP0008995_early_reproductive_senescence0.94972461
85MP0002234_abnormal_pharynx_morphology0.93740591
86MP0009672_abnormal_birth_weight0.92831689
87MP0000631_abnormal_neuroendocrine_gland0.91430679
88MP0000579_abnormal_nail_morphology0.90276186
89MP0005391_vision/eye_phenotype0.85791810
90MP0001119_abnormal_female_reproductive0.84277450
91MP0003705_abnormal_hypodermis_morpholog0.83188361
92MP0004272_abnormal_basement_membrane0.82918261
93MP0003861_abnormal_nervous_system0.82861870
94MP0009053_abnormal_anal_canal0.82673544
95MP0002429_abnormal_blood_cell0.82530287
96MP0000534_abnormal_ureter_morphology0.82057693
97MP0002098_abnormal_vibrissa_morphology0.81321797
98MP0003136_yellow_coat_color0.81232285
99MP0009703_decreased_birth_body0.79258873
100MP0002095_abnormal_skin_pigmentation0.79148313
101MP0003938_abnormal_ear_development0.77176096
102MP0003941_abnormal_skin_development0.76916979
103MP0002102_abnormal_ear_morphology0.75405565
104MP0005023_abnormal_wound_healing0.74526750
105MP0002075_abnormal_coat/hair_pigmentati0.74487705
106MP0000462_abnormal_digestive_system0.73845370
107MP0009333_abnormal_splenocyte_physiolog0.73500641
108MP0003119_abnormal_digestive_system0.72864881
109MP0001915_intracranial_hemorrhage0.72457937
110MP0000477_abnormal_intestine_morphology0.71961700
111MP0004147_increased_porphyrin_level0.71503613
112MP0009697_abnormal_copulation0.70993854
113MP0002116_abnormal_craniofacial_bone0.70192872
114MP0002938_white_spotting0.70100008
115MP0005384_cellular_phenotype0.69770451
116MP0010368_abnormal_lymphatic_system0.69747705
117MP0002796_impaired_skin_barrier0.68789961
118MP0005621_abnormal_cell_physiology0.68779336
119MP0005075_abnormal_melanosome_morpholog0.68356393
120MP0002111_abnormal_tail_morphology0.67841916
121MP0000762_abnormal_tongue_morphology0.67098002
122MP0005501_abnormal_skin_physiology0.66491137
123MP0000716_abnormal_immune_system0.65952797
124MP0000858_altered_metastatic_potential0.65305274
125MP0000371_diluted_coat_color0.65129508
126MP0002160_abnormal_reproductive_system0.64291799
127MP0003698_abnormal_male_reproductive0.64221061
128MP0002925_abnormal_cardiovascular_devel0.62730303
129MP0000358_abnormal_cell_content/0.62653300
130MP0003221_abnormal_cardiomyocyte_apopto0.61845038
131MP0000383_abnormal_hair_follicle0.61290021
132MP0002166_altered_tumor_susceptibility0.59498437
133MP0002092_abnormal_eye_morphology0.58741573
134MP0002006_tumorigenesis0.55815341
135MP0002877_abnormal_melanocyte_morpholog0.55787769
136MP0000465_gastrointestinal_hemorrhage0.55366910
137MP0001873_stomach_inflammation0.54064105
138MP0000266_abnormal_heart_morphology0.53960600
139MP0002132_abnormal_respiratory_system0.53731954
140MP0002653_abnormal_ependyma_morphology0.52683051
141MP0004233_abnormal_muscle_weight0.52261204
142MP0003937_abnormal_limbs/digits/tail_de0.51988814
143MP0003115_abnormal_respiratory_system0.51882193
144MP0000428_abnormal_craniofacial_morphol0.51819267
145MP0005389_reproductive_system_phenotype0.50913734

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.70209619
2Chromsome breakage (HP:0040012)4.39503385
3Reticulocytopenia (HP:0001896)4.25646847
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.09574743
5Aplastic anemia (HP:0001915)3.79539596
6Colon cancer (HP:0003003)3.73368108
7Abnormal number of erythroid precursors (HP:0012131)3.62656810
8Abnormality of cells of the erythroid lineage (HP:0012130)3.62369033
9Abnormality of chromosome stability (HP:0003220)3.56951394
10Medulloblastoma (HP:0002885)3.53313602
11Selective tooth agenesis (HP:0001592)3.35448743
12Meckel diverticulum (HP:0002245)3.26582937
13Abnormality of the preputium (HP:0100587)3.25199005
14Abnormality of the ileum (HP:0001549)3.22364846
15Oral leukoplakia (HP:0002745)3.17001069
16Myelodysplasia (HP:0002863)3.14749137
1711 pairs of ribs (HP:0000878)3.14271125
18Aplasia/Hypoplasia of the uvula (HP:0010293)3.07966848
19Ependymoma (HP:0002888)3.06548226
20Thrombocytosis (HP:0001894)2.95686871
21Rhabdomyosarcoma (HP:0002859)2.93771935
22Breast hypoplasia (HP:0003187)2.92984823
23Duodenal stenosis (HP:0100867)2.83529326
24Small intestinal stenosis (HP:0012848)2.83529326
25Patellar aplasia (HP:0006443)2.78130981
26Nephroblastoma (Wilms tumor) (HP:0002667)2.77851975
27Acute lymphatic leukemia (HP:0006721)2.68087900
28Absent thumb (HP:0009777)2.67105211
29Increased nuchal translucency (HP:0010880)2.60396782
30Acute myeloid leukemia (HP:0004808)2.54994868
31Embryonal renal neoplasm (HP:0011794)2.53869072
32Aplasia/Hypoplasia of the patella (HP:0006498)2.52607776
33Volvulus (HP:0002580)2.50917456
34Ectopic kidney (HP:0000086)2.45640978
35Hypoplastic labia majora (HP:0000059)2.42982106
36Bone marrow hypocellularity (HP:0005528)2.41226656
37Agnosia (HP:0010524)2.38074267
38Amaurosis fugax (HP:0100576)2.37989972
39Breast carcinoma (HP:0003002)2.37054007
40Impulsivity (HP:0100710)2.35893744
41Abnormality of the anterior horn cell (HP:0006802)2.34989953
42Degeneration of anterior horn cells (HP:0002398)2.34989953
43Carpal bone hypoplasia (HP:0001498)2.34976598
44Aplasia/Hypoplasia of the sternum (HP:0006714)2.34940058
45Abnormal number of incisors (HP:0011064)2.33818132
46Pallor (HP:0000980)2.32335545
47Abnormality of the nasal septum (HP:0000419)2.31976561
48Abnormality of the carotid arteries (HP:0005344)2.31704962
49Proximal placement of thumb (HP:0009623)2.30239550
50Abnormality of the duodenum (HP:0002246)2.27936186
51Basal cell carcinoma (HP:0002671)2.26028453
52Sloping forehead (HP:0000340)2.25886482
53Deviation of the thumb (HP:0009603)2.25709551
54Macrocytic anemia (HP:0001972)2.24706967
55Supernumerary spleens (HP:0009799)2.23845414
56Neoplasm of the pancreas (HP:0002894)2.23219176
57Abnormal lung lobation (HP:0002101)2.22365920
58Facial hemangioma (HP:0000329)2.21697221
59Microretrognathia (HP:0000308)2.21185659
60Abnormality of the labia majora (HP:0012881)2.19099076
61Clubbing of toes (HP:0100760)2.18537246
62Embryonal neoplasm (HP:0002898)2.17898293
63Missing ribs (HP:0000921)2.16142738
64Atresia of the external auditory canal (HP:0000413)2.15043984
65Premature graying of hair (HP:0002216)2.14637280
66Neoplasm of striated muscle (HP:0009728)2.12153835
67Rough bone trabeculation (HP:0100670)2.11825743
68Neoplasm of the colon (HP:0100273)2.09155308
69Tracheoesophageal fistula (HP:0002575)2.09148248
70Abnormality of pyrimidine metabolism (HP:0004353)2.07224120
71Absent radius (HP:0003974)2.06043724
72Short 4th metacarpal (HP:0010044)2.05405248
73Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05405248
74Abnormality of the labia minora (HP:0012880)2.04450364
75Abnormality of DNA repair (HP:0003254)2.02692457
76Abnormality of the parathyroid morphology (HP:0011766)2.02248175
77Abnormal spermatogenesis (HP:0008669)2.01567176
78Slender long bone (HP:0003100)1.98531367
79Cafe-au-lait spot (HP:0000957)1.97729230
80Broad palm (HP:0001169)1.97423682
81Short middle phalanx of the 5th finger (HP:0004220)1.95729876
82Preaxial hand polydactyly (HP:0001177)1.95285569
83Biliary tract neoplasm (HP:0100574)1.93563817
84Pancytopenia (HP:0001876)1.93399964
85Median cleft lip (HP:0000161)1.92873803
86High pitched voice (HP:0001620)1.90677280
87Preaxial foot polydactyly (HP:0001841)1.90414270
88Prominent nose (HP:0000448)1.89270473
89Cutaneous finger syndactyly (HP:0010554)1.89102933
90Neoplasm of the adrenal cortex (HP:0100641)1.88779670
91Abnormality of reticulocytes (HP:0004312)1.88616770
92Depressed nasal tip (HP:0000437)1.87771450
93Aplasia involving forearm bones (HP:0009822)1.86653861
94Absent forearm bone (HP:0003953)1.86653861
95Glioma (HP:0009733)1.86501822
96True hermaphroditism (HP:0010459)1.85550245
97Pancreatic fibrosis (HP:0100732)1.85277962
98Neoplasm of the oral cavity (HP:0100649)1.85010057
99Abdominal situs inversus (HP:0003363)1.84394994
100Abnormality of abdominal situs (HP:0011620)1.84394994
101Long eyelashes (HP:0000527)1.84125628
102Small hand (HP:0200055)1.84051101
103Deep philtrum (HP:0002002)1.83895708
104Triphalangeal thumb (HP:0001199)1.83705923
105Abnormality of chromosome segregation (HP:0002916)1.83684082
106Short thumb (HP:0009778)1.83033403
107Abnormality of cochlea (HP:0000375)1.82994652
108Astrocytoma (HP:0009592)1.80214870
109Abnormality of the astrocytes (HP:0100707)1.80214870
110IgM deficiency (HP:0002850)1.80138134
111Anophthalmia (HP:0000528)1.79514008
112Abnormality of the fingertips (HP:0001211)1.79365765
113Duplicated collecting system (HP:0000081)1.79113575
114Neoplasm of the rectum (HP:0100743)1.78747707
115Lymphoma (HP:0002665)1.77484092
116Poikiloderma (HP:0001029)1.76108954
117Ovarian neoplasm (HP:0100615)1.75618259
118Cutaneous syndactyly (HP:0012725)1.74050544
119Broad thumb (HP:0011304)1.73968477
120Abnormality of the heme biosynthetic pathway (HP:0010472)1.73671212
121Ankle contracture (HP:0006466)1.73522342
122Squamous cell carcinoma (HP:0002860)1.72550487
123Stenosis of the external auditory canal (HP:0000402)1.72465662
124Abnormality of the pons (HP:0007361)1.71163347
125Abnormality of the renal collecting system (HP:0004742)1.70852231
126Diastasis recti (HP:0001540)1.70547263
127Cerebellar dysplasia (HP:0007033)1.68562101
128Pancreatic cysts (HP:0001737)1.66960651
129Microglossia (HP:0000171)1.66711444
130Facial cleft (HP:0002006)1.66066480
131Duplication of thumb phalanx (HP:0009942)1.65701500
132Septo-optic dysplasia (HP:0100842)1.65457195
133Bifid tongue (HP:0010297)1.65373033
134Short hallux (HP:0010109)1.64005336
135Esophageal atresia (HP:0002032)1.62954848
136Arteriovenous malformation (HP:0100026)1.62473152
137Dandy-Walker malformation (HP:0001305)1.61398062
138Partial agenesis of the corpus callosum (HP:0001338)1.59038583
139Gastrointestinal atresia (HP:0002589)1.58965927
140Abnormal biliary tract morphology (HP:0012440)1.58843710
141Aplasia/Hypoplasia of the tongue (HP:0010295)1.57044839
142Optic nerve hypoplasia (HP:0000609)1.56097696
143Prostate neoplasm (HP:0100787)1.55312314
144Short middle phalanx of finger (HP:0005819)1.55253873
145Abnormality of the septum pellucidum (HP:0007375)1.54787087
146Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.53564742
147High anterior hairline (HP:0009890)1.52417044
148Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.52319674
149Chronic hepatic failure (HP:0100626)1.51632360
150Horseshoe kidney (HP:0000085)1.51421032

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.73583580
2* WEE14.24454828
3BUB13.30349282
4MST43.28421481
5NEK22.85440279
6TAF12.73961333
7ACVR1B2.70471726
8FLT32.67442764
9PBK2.55484101
10NUAK12.18656028
11RPS6KB22.11296435
12CDK122.09599665
13PASK2.09096939
14VRK22.07567025
15PNCK2.07560902
16CCNB12.00014857
17EIF2AK11.99106539
18EEF2K1.99098881
19TTK1.98872635
20NEK11.95389040
21MKNK11.93400968
22* PLK11.89459409
23CDK71.86796470
24STK101.85907163
25SRPK11.84397115
26ATR1.81973053
27STK38L1.78638603
28TGFBR11.77124389
29MAP3K101.73250143
30TSSK61.70504803
31MKNK21.70087336
32CDK41.70073208
33AKT31.68884847
34ERBB41.65349833
35PKN21.60311055
36AURKB1.60147780
37NME21.58301171
38LATS11.56941266
39SCYL21.56173567
40RPS6KA41.53838511
41TRIM281.52103479
42SMG11.51426897
43DYRK31.49442827
44TNIK1.46526054
45VRK11.46052248
46STK161.44764363
47MAP3K81.39034827
48FRK1.33997510
49BMPR1B1.32727461
50CHEK21.29746914
51CDK81.27804998
52MAP2K31.25018866
53EIF2AK31.23402321
54PLK31.23318659
55EPHA21.23172452
56CHEK11.23168463
57EIF2AK21.19241911
58* BRSK21.12647345
59PLK41.10276950
60WNK31.09475130
61STK41.07045993
62RIPK11.01894501
63FGFR10.98837368
64KIT0.97062519
65LRRK20.95648194
66PIM10.95488590
67ATM0.94646275
68MAPKAPK30.94502620
69NEK90.92002993
70GRK10.90593008
71* BRSK10.90440574
72BCR0.90095950
73PAK40.89418651
74AURKA0.88895339
75BTK0.88831917
76CSF1R0.88184691
77CDK60.88155023
78CDK20.85513679
79MAP4K10.84362664
80CAMK1G0.83786981
81CASK0.82777007
82MELK0.80034309
83BRD40.79930270
84MAP3K110.77990654
85STK30.76717851
86TEC0.72103716
87FGFR20.68671938
88STK390.68630522
89CDK30.67751487
90PIM20.67312868
91BCKDK0.64702802
92ERBB30.64058688
93CLK10.64031039
94TLK10.60221704
95ZAP700.58279267
96* CDK10.58035258
97CSNK2A20.57983625
98PDK40.57421278
99PDK30.57421278
100TESK20.57106354
101MAPK110.56485924
102* CSNK2A10.54439084
103ZAK0.52962963
104MAPKAPK50.52677032
105MATK0.51598290
106TRIB30.51480517
107YES10.49311942
108MTOR0.49306239
109ALK0.47027819
110MAP3K30.46396946
111DYRK20.45995914
112CSNK1G10.45474615
113AKT20.44572397
114NLK0.44243499
115MET0.43979045
116PLK20.42766223
117LATS20.41029244
118DMPK0.40315752
119TAOK20.39637277
120JAK30.38797456
121PRKG20.38342451
122DAPK10.38264000
123PRKCI0.36966197
124MAP3K60.34422837
125MAPK150.33140636
126CAMK1D0.32984924
127OXSR10.32556225
128PAK30.32535543
129GRK60.32449397
130FER0.32116948
131EPHB20.31163872
132CSNK1E0.31086033
133CSNK1A1L0.30906716
134NME10.30594171
135RPS6KA60.30271081
136PRKDC0.29764235
137WNK40.29710543
138KDR0.29234869
139HIPK20.28793008
140PRKCE0.28673559
141RPS6KA50.28265308
142RPS6KC10.28014791
143RPS6KL10.28014791
144* MAPK140.27879658
145CSNK1D0.26111730
146MARK30.25955188
147PAK10.25781059
148MAPKAPK20.25732824
149STK240.25680400
150CDK90.24652432

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.86463649
2Mismatch repair_Homo sapiens_hsa034304.73457167
3Base excision repair_Homo sapiens_hsa034103.44869202
4Homologous recombination_Homo sapiens_hsa034403.42727253
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.25904352
6Spliceosome_Homo sapiens_hsa030403.04085963
7* Cell cycle_Homo sapiens_hsa041103.02973020
8RNA transport_Homo sapiens_hsa030132.93812608
9Nucleotide excision repair_Homo sapiens_hsa034202.93376680
10Ribosome_Homo sapiens_hsa030102.85750044
11One carbon pool by folate_Homo sapiens_hsa006702.60359932
12Fanconi anemia pathway_Homo sapiens_hsa034602.42918182
13RNA polymerase_Homo sapiens_hsa030202.35321478
14Pyrimidine metabolism_Homo sapiens_hsa002402.32775629
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.05880528
16Non-homologous end-joining_Homo sapiens_hsa034501.99915184
17RNA degradation_Homo sapiens_hsa030181.87665331
18Basal transcription factors_Homo sapiens_hsa030221.79736754
19mRNA surveillance pathway_Homo sapiens_hsa030151.76402400
20p53 signaling pathway_Homo sapiens_hsa041151.58994995
21Proteasome_Homo sapiens_hsa030501.58103915
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.39732542
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37626017
24Hedgehog signaling pathway_Homo sapiens_hsa043401.35375953
25Propanoate metabolism_Homo sapiens_hsa006401.32741870
26Steroid biosynthesis_Homo sapiens_hsa001001.22968727
27Purine metabolism_Homo sapiens_hsa002301.18317567
28Herpes simplex infection_Homo sapiens_hsa051681.15605668
29Thyroid cancer_Homo sapiens_hsa052161.12293249
30Circadian rhythm_Homo sapiens_hsa047101.07100303
31Oocyte meiosis_Homo sapiens_hsa041141.06589313
32Epstein-Barr virus infection_Homo sapiens_hsa051691.01897278
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01352776
34Antigen processing and presentation_Homo sapiens_hsa046121.00579678
35Pentose phosphate pathway_Homo sapiens_hsa000301.00214775
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99915358
37Viral carcinogenesis_Homo sapiens_hsa052030.95167409
38Nitrogen metabolism_Homo sapiens_hsa009100.92461698
39Systemic lupus erythematosus_Homo sapiens_hsa053220.90981909
40Biosynthesis of amino acids_Homo sapiens_hsa012300.90595592
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90373662
42Selenocompound metabolism_Homo sapiens_hsa004500.88253341
43HTLV-I infection_Homo sapiens_hsa051660.88061543
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87635181
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87371970
46Folate biosynthesis_Homo sapiens_hsa007900.85958096
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85616672
48Small cell lung cancer_Homo sapiens_hsa052220.80973548
49N-Glycan biosynthesis_Homo sapiens_hsa005100.79416998
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78854478
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.78654257
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.73163833
53Tight junction_Homo sapiens_hsa045300.72115335
54MicroRNAs in cancer_Homo sapiens_hsa052060.71606124
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69762640
56Melanoma_Homo sapiens_hsa052180.69745168
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69385471
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65339099
59Legionellosis_Homo sapiens_hsa051340.59246274
60Carbon metabolism_Homo sapiens_hsa012000.59105062
61Vitamin B6 metabolism_Homo sapiens_hsa007500.55480851
62Lysine degradation_Homo sapiens_hsa003100.54495393
63Pyruvate metabolism_Homo sapiens_hsa006200.52461508
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51529699
65Caffeine metabolism_Homo sapiens_hsa002320.51356175
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51107409
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50237670
68FoxO signaling pathway_Homo sapiens_hsa040680.49609703
69Regulation of autophagy_Homo sapiens_hsa041400.49593066
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47685797
71Colorectal cancer_Homo sapiens_hsa052100.46933927
72Notch signaling pathway_Homo sapiens_hsa043300.46891741
73Primary immunodeficiency_Homo sapiens_hsa053400.46340368
74Retinol metabolism_Homo sapiens_hsa008300.45598143
75Phototransduction_Homo sapiens_hsa047440.44915084
76Hepatitis B_Homo sapiens_hsa051610.44566539
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44403488
78Glutathione metabolism_Homo sapiens_hsa004800.42798993
79Chronic myeloid leukemia_Homo sapiens_hsa052200.41874349
80Hippo signaling pathway_Homo sapiens_hsa043900.41805215
81Basal cell carcinoma_Homo sapiens_hsa052170.41047575
82PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40993076
83TGF-beta signaling pathway_Homo sapiens_hsa043500.40406163
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40339233
85Apoptosis_Homo sapiens_hsa042100.39364861
86Galactose metabolism_Homo sapiens_hsa000520.38971752
87Acute myeloid leukemia_Homo sapiens_hsa052210.38864408
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.38563954
89Sulfur relay system_Homo sapiens_hsa041220.37817616
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37703832
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36738509
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36093073
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35790225
94Butanoate metabolism_Homo sapiens_hsa006500.35046225
95ECM-receptor interaction_Homo sapiens_hsa045120.34677055
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34207237
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33978320
98Melanogenesis_Homo sapiens_hsa049160.32909083
99Influenza A_Homo sapiens_hsa051640.32733650
100Shigellosis_Homo sapiens_hsa051310.32628859
101Bladder cancer_Homo sapiens_hsa052190.30560505
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.30552586
103Pathways in cancer_Homo sapiens_hsa052000.30131540
104beta-Alanine metabolism_Homo sapiens_hsa004100.29763650
105Measles_Homo sapiens_hsa051620.29709620
106Adherens junction_Homo sapiens_hsa045200.29589835
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29354569
108Proteoglycans in cancer_Homo sapiens_hsa052050.29288037
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29149703
110Renin-angiotensin system_Homo sapiens_hsa046140.28957760
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28599425
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28284179
113Arginine and proline metabolism_Homo sapiens_hsa003300.28145992
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27328310
115Vitamin digestion and absorption_Homo sapiens_hsa049770.27056237
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26526483
117HIF-1 signaling pathway_Homo sapiens_hsa040660.26511261
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24284322
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.24240855
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24085656
121Non-small cell lung cancer_Homo sapiens_hsa052230.23766009
122Protein digestion and absorption_Homo sapiens_hsa049740.23282891
123Hematopoietic cell lineage_Homo sapiens_hsa046400.22370180
124Fructose and mannose metabolism_Homo sapiens_hsa000510.22340802
125Alcoholism_Homo sapiens_hsa050340.22318553
126Chemical carcinogenesis_Homo sapiens_hsa052040.21826905
127Sphingolipid metabolism_Homo sapiens_hsa006000.21761400
128Fatty acid degradation_Homo sapiens_hsa000710.21581672
129Olfactory transduction_Homo sapiens_hsa047400.21558030
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.21032849
131Metabolic pathways_Homo sapiens_hsa011000.21017323
132Protein export_Homo sapiens_hsa030600.20667279
133Pancreatic cancer_Homo sapiens_hsa052120.19718262
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19358924
135Prostate cancer_Homo sapiens_hsa052150.16667845
136Viral myocarditis_Homo sapiens_hsa054160.16314627
137B cell receptor signaling pathway_Homo sapiens_hsa046620.15846359
138mTOR signaling pathway_Homo sapiens_hsa041500.15600178
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15346658
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.14584685
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.14031442
142Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.13777230
143Wnt signaling pathway_Homo sapiens_hsa043100.13669525
144Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.13419150

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