WFDC11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of memory T cell differentiation (GO:0043380)5.95390016
2negative regulation of multicellular organism growth (GO:0040015)5.44590028
3kynurenine metabolic process (GO:0070189)5.31767753
4indolalkylamine catabolic process (GO:0046218)5.16481282
5tryptophan catabolic process (GO:0006569)5.16481282
6indole-containing compound catabolic process (GO:0042436)5.16481282
7regulation of establishment of cell polarity (GO:2000114)4.68247632
8tryptophan metabolic process (GO:0006568)4.58229371
9indolalkylamine metabolic process (GO:0006586)4.45271568
10response to pheromone (GO:0019236)4.32486957
11behavioral response to nicotine (GO:0035095)4.22533363
12cytoplasmic mRNA processing body assembly (GO:0033962)4.09117350
13regulation of action potential (GO:0098900)4.07243892
14L-fucose catabolic process (GO:0042355)4.03733580
15fucose catabolic process (GO:0019317)4.03733580
16L-fucose metabolic process (GO:0042354)4.03733580
17regulation of MHC class I biosynthetic process (GO:0045343)4.02149874
18detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.93701717
19sex differentiation (GO:0007548)3.92424154
20regulation of establishment or maintenance of cell polarity (GO:0032878)3.89510246
21neural tube formation (GO:0001841)3.86654344
22cerebellar Purkinje cell differentiation (GO:0021702)3.77702395
23L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.73950912
24positive regulation of vasculogenesis (GO:2001214)3.67796877
25reflex (GO:0060004)3.52178375
26amine catabolic process (GO:0009310)3.47938821
27cellular biogenic amine catabolic process (GO:0042402)3.47938821
28negative regulation of mast cell activation (GO:0033004)3.38911423
29amino acid salvage (GO:0043102)3.38043995
30L-methionine salvage (GO:0071267)3.38043995
31L-methionine biosynthetic process (GO:0071265)3.38043995
32piRNA metabolic process (GO:0034587)3.33588608
33detection of light stimulus involved in visual perception (GO:0050908)3.33542201
34detection of light stimulus involved in sensory perception (GO:0050962)3.33542201
35ADP metabolic process (GO:0046031)3.33225651
36righting reflex (GO:0060013)3.31722462
37establishment of protein localization to Golgi (GO:0072600)3.31052774
38synaptic transmission, cholinergic (GO:0007271)3.28870239
39behavioral response to ethanol (GO:0048149)3.22075069
40cellular ketone body metabolic process (GO:0046950)3.21903999
41auditory receptor cell stereocilium organization (GO:0060088)3.17204447
42neuronal action potential propagation (GO:0019227)3.14649536
43cholesterol catabolic process (GO:0006707)3.13721070
44sterol catabolic process (GO:0016127)3.13721070
45indole-containing compound metabolic process (GO:0042430)3.13322907
46protein K11-linked deubiquitination (GO:0035871)3.13111262
47neuronal action potential (GO:0019228)3.04417919
48regulation of vasculogenesis (GO:2001212)3.03215519
49ketone body metabolic process (GO:1902224)2.99274518
50alternative mRNA splicing, via spliceosome (GO:0000380)2.97428836
51photoreceptor cell maintenance (GO:0045494)2.96155275
52regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.93636369
53tachykinin receptor signaling pathway (GO:0007217)2.91069328
54negative regulation of type 2 immune response (GO:0002829)2.88599447
55aromatic amino acid family catabolic process (GO:0009074)2.88051145
56platelet dense granule organization (GO:0060155)2.87373501
57methionine biosynthetic process (GO:0009086)2.85330910
58gamma-aminobutyric acid transport (GO:0015812)2.84818821
59benzene-containing compound metabolic process (GO:0042537)2.82827806
60epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.81620277
61NAD biosynthetic process (GO:0009435)2.81044029
62proline transport (GO:0015824)2.78650369
63nucleoside diphosphate catabolic process (GO:0009134)2.75331661
64DNA methylation involved in gamete generation (GO:0043046)2.75183891
65regulation of sarcomere organization (GO:0060297)2.73959081
66cAMP catabolic process (GO:0006198)2.73253342
67lipid particle organization (GO:0034389)2.72312061
68bile acid biosynthetic process (GO:0006699)2.69897205
69adaptation of signaling pathway (GO:0023058)2.67979442
70acrosome assembly (GO:0001675)2.67626576
71inner ear receptor stereocilium organization (GO:0060122)2.67256219
72estrogen biosynthetic process (GO:0006703)2.65724716
73protein targeting to Golgi (GO:0000042)2.65405524
74dopamine transport (GO:0015872)2.64533686
75centrosome duplication (GO:0051298)2.63126866
76protein-chromophore linkage (GO:0018298)2.62435513
77seminiferous tubule development (GO:0072520)2.61573223
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.60272042
79axoneme assembly (GO:0035082)2.59995683
80disruption of cells of other organism (GO:0044364)2.59134287
81killing of cells of other organism (GO:0031640)2.59134287
82endoderm formation (GO:0001706)2.58681696
83cilium morphogenesis (GO:0060271)2.58291176
84sulfation (GO:0051923)2.56309345
85multicellular organism reproduction (GO:0032504)2.56221841
86rRNA catabolic process (GO:0016075)2.55514920
87interferon-gamma production (GO:0032609)2.55150007
88detection of mechanical stimulus involved in sensory perception (GO:0050974)2.53478455
89detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.53386602
90protein polyglutamylation (GO:0018095)2.51153477
91phospholipid translocation (GO:0045332)2.50011526
92lipid translocation (GO:0034204)2.50011526
93negative regulation of receptor-mediated endocytosis (GO:0048261)2.49272261
94glycerophospholipid catabolic process (GO:0046475)2.49124351
95male meiosis I (GO:0007141)2.48224912
96cilium or flagellum-dependent cell motility (GO:0001539)2.46975521
97left/right axis specification (GO:0070986)2.44639912
98epithelial cilium movement (GO:0003351)2.42702083
99central nervous system neuron axonogenesis (GO:0021955)2.42142656
100cyclic nucleotide catabolic process (GO:0009214)2.41820901

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.87930807
2GBX2_23144817_ChIP-Seq_PC3_Human3.30990096
3IGF1R_20145208_ChIP-Seq_DFB_Human3.10772979
4ZNF274_21170338_ChIP-Seq_K562_Hela3.05845712
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.82863586
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.74476672
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.74007016
8TAF15_26573619_Chip-Seq_HEK293_Human2.72578183
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.51618890
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46808127
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.46793699
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.45582652
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.35727811
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.18493767
15FUS_26573619_Chip-Seq_HEK293_Human2.17709768
16ER_23166858_ChIP-Seq_MCF-7_Human2.15751298
17EZH2_22144423_ChIP-Seq_EOC_Human2.13069615
18P300_19829295_ChIP-Seq_ESCs_Human2.01850122
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98386340
20BCAT_22108803_ChIP-Seq_LS180_Human1.98104974
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.97547275
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83691505
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81883028
24UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.76925328
25EWS_26573619_Chip-Seq_HEK293_Human1.76762579
26STAT3_23295773_ChIP-Seq_U87_Human1.74865659
27SMAD4_21799915_ChIP-Seq_A2780_Human1.72641785
28CBP_20019798_ChIP-Seq_JUKART_Human1.69365722
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.69365722
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66130845
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.63165735
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60451651
33IRF1_19129219_ChIP-ChIP_H3396_Human1.60354666
34TCF4_23295773_ChIP-Seq_U87_Human1.58857329
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56251277
36AR_25329375_ChIP-Seq_VCAP_Human1.54340278
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49347991
38NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48348329
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.46608288
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.45977438
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42483539
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41980819
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41926134
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41624301
45KLF5_20875108_ChIP-Seq_MESCs_Mouse1.38055071
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36933662
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36644020
48TP53_22573176_ChIP-Seq_HFKS_Human1.35951834
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35591166
50TCF4_22108803_ChIP-Seq_LS180_Human1.35335532
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34707022
52RUNX2_22187159_ChIP-Seq_PCA_Human1.34659533
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32840110
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31821429
55NANOG_19829295_ChIP-Seq_ESCs_Human1.29828929
56SOX2_19829295_ChIP-Seq_ESCs_Human1.29828929
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.29370498
58FLI1_21867929_ChIP-Seq_TH2_Mouse1.27780766
59SMAD4_21741376_ChIP-Seq_EPCs_Human1.27412828
60FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25897011
61CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25180422
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.23711689
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.23630273
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23630273
65CRX_20693478_ChIP-Seq_RETINA_Mouse1.21277334
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20934834
67CDX2_22108803_ChIP-Seq_LS180_Human1.20259480
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.19738836
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18744024
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14475917
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13369858
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13369858
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.12366936
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12176096
75REST_21632747_ChIP-Seq_MESCs_Mouse1.11437624
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10911929
77TAL1_26923725_Chip-Seq_HPCs_Mouse1.10685916
78P53_22387025_ChIP-Seq_ESCs_Mouse1.10429863
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.10382144
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.10212019
81STAT3_18555785_Chip-Seq_ESCs_Mouse1.08256241
82AR_20517297_ChIP-Seq_VCAP_Human1.08180209
83TP53_16413492_ChIP-PET_HCT116_Human1.06927358
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06690303
85KDM2B_26808549_Chip-Seq_REH_Human1.06604216
86OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06154735
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04966717
88SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04252005
89NCOR_22424771_ChIP-Seq_293T_Human1.03688590
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03051748
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.02661284
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02394066
93RNF2_27304074_Chip-Seq_NSC_Mouse1.00760428
94P300_18555785_Chip-Seq_ESCs_Mouse1.00749311
95TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00736909
96OCT1_27270436_Chip-Seq_PROSTATE_Human0.99028009
97TBL1_22424771_ChIP-Seq_293T_Human0.98839305
98AR_21572438_ChIP-Seq_LNCaP_Human0.98306738
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98093362
100CMYC_18555785_Chip-Seq_ESCs_Mouse0.97990755

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.46233165
2MP0003195_calcinosis3.18168843
3MP0002736_abnormal_nociception_after3.14056265
4MP0003011_delayed_dark_adaptation3.13134091
5MP0001986_abnormal_taste_sensitivity3.11875606
6MP0001968_abnormal_touch/_nociception2.92699601
7MP0002102_abnormal_ear_morphology2.74943569
8MP0003252_abnormal_bile_duct2.66589309
9MP0005551_abnormal_eye_electrophysiolog2.62464056
10MP0003646_muscle_fatigue2.40747464
11MP0005253_abnormal_eye_physiology2.32239407
12MP0009046_muscle_twitch2.22367923
13MP0002837_dystrophic_cardiac_calcinosis2.21980680
14MP0006072_abnormal_retinal_apoptosis2.20235487
15MP0008877_abnormal_DNA_methylation2.13270577
16MP0001501_abnormal_sleep_pattern2.06367917
17MP0002638_abnormal_pupillary_reflex2.02175328
18MP0009745_abnormal_behavioral_response1.98292481
19MP0002876_abnormal_thyroid_physiology1.90037634
20MP0000372_irregular_coat_pigmentation1.87572887
21MP0003880_abnormal_central_pattern1.81410706
22MP0004147_increased_porphyrin_level1.77533451
23MP0000427_abnormal_hair_cycle1.74547785
24MP0002163_abnormal_gland_morphology1.74450933
25MP0005646_abnormal_pituitary_gland1.71610645
26MP0006276_abnormal_autonomic_nervous1.69015019
27MP0001486_abnormal_startle_reflex1.68786892
28MP0002272_abnormal_nervous_system1.66983999
29MP0003787_abnormal_imprinting1.63757853
30MP0001984_abnormal_olfaction1.61845945
31MP0004043_abnormal_pH_regulation1.60788284
32MP0005075_abnormal_melanosome_morpholog1.54059312
33MP0004215_abnormal_myocardial_fiber1.51139078
34MP0000383_abnormal_hair_follicle1.50342767
35MP0008875_abnormal_xenobiotic_pharmacok1.46603858
36MP0004142_abnormal_muscle_tone1.41834907
37MP0001529_abnormal_vocalization1.40596755
38MP0000371_diluted_coat_color1.37949300
39MP0005386_behavior/neurological_phenoty1.36809154
40MP0004924_abnormal_behavior1.36809154
41MP0005379_endocrine/exocrine_gland_phen1.33940916
42MP0008872_abnormal_physiological_respon1.33895526
43MP0005174_abnormal_tail_pigmentation1.30217492
44MP0002064_seizures1.27922747
45MP0005410_abnormal_fertilization1.23719934
46MP0005084_abnormal_gallbladder_morpholo1.22525074
47MP0003137_abnormal_impulse_conducting1.21197159
48MP0005645_abnormal_hypothalamus_physiol1.17080390
49MP0002234_abnormal_pharynx_morphology1.12937224
50MP0003950_abnormal_plasma_membrane1.12007047
51MP0008057_abnormal_DNA_replication1.10522999
52MP0002067_abnormal_sensory_capabilities1.09629881
53MP0005377_hearing/vestibular/ear_phenot1.05813529
54MP0003878_abnormal_ear_physiology1.05813529
55MP0002572_abnormal_emotion/affect_behav1.05512555
56MP0003718_maternal_effect1.05318069
57MP0006035_abnormal_mitochondrial_morpho1.03671803
58MP0002733_abnormal_thermal_nociception1.00364151
59MP0004885_abnormal_endolymph0.99218259
60MP0002229_neurodegeneration0.98965583
61MP0005670_abnormal_white_adipose0.97599962
62MP0002735_abnormal_chemical_nociception0.96643861
63MP0000631_abnormal_neuroendocrine_gland0.92270369
64MP0002138_abnormal_hepatobiliary_system0.91442769
65MP0005085_abnormal_gallbladder_physiolo0.90979372
66MP0001970_abnormal_pain_threshold0.90617364
67MP0005647_abnormal_sex_gland0.90100119
68MP0004484_altered_response_of0.89217555
69MP0004133_heterotaxia0.88271920
70MP0006036_abnormal_mitochondrial_physio0.87775412
71MP0001324_abnormal_eye_pigmentation0.86557915
72MP0001485_abnormal_pinna_reflex0.86349260
73MP0001764_abnormal_homeostasis0.84832494
74MP0005195_abnormal_posterior_eye0.84082190
75MP0003121_genomic_imprinting0.83528266
76MP0002693_abnormal_pancreas_physiology0.82766361
77MP0005423_abnormal_somatic_nervous0.82372014
78MP0008995_early_reproductive_senescence0.81427168
79MP0010386_abnormal_urinary_bladder0.80515966
80MP0003122_maternal_imprinting0.80060562
81MP0000230_abnormal_systemic_arterial0.80007961
82MP0004085_abnormal_heartbeat0.79313036
83MP0002928_abnormal_bile_duct0.78963878
84MP0002752_abnormal_somatic_nervous0.78917204
85MP0004145_abnormal_muscle_electrophysio0.78431938
86MP0003635_abnormal_synaptic_transmissio0.78084847
87MP0003698_abnormal_male_reproductive0.75643156
88MP0004742_abnormal_vestibular_system0.75351046
89MP0002160_abnormal_reproductive_system0.74554973
90MP0002557_abnormal_social/conspecific_i0.73532020
91MP0001502_abnormal_circadian_rhythm0.73130768
92MP0003183_abnormal_peptide_metabolism0.73124051
93MP0000653_abnormal_sex_gland0.72561408
94MP0008961_abnormal_basal_metabolism0.70693069
95MP0002751_abnormal_autonomic_nervous0.70601442
96MP0009697_abnormal_copulation0.69045070
97MP0005391_vision/eye_phenotype0.68537493
98MP0001963_abnormal_hearing_physiology0.68198190
99MP0002063_abnormal_learning/memory/cond0.68119008
100MP0002938_white_spotting0.66083579

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)5.55427061
2Progressive cerebellar ataxia (HP:0002073)4.58467204
3Gaze-evoked nystagmus (HP:0000640)4.21839261
4Pancreatic cysts (HP:0001737)4.13025895
5Pendular nystagmus (HP:0012043)3.80858571
6Pancreatic fibrosis (HP:0100732)3.80710839
7True hermaphroditism (HP:0010459)3.58428813
8Molar tooth sign on MRI (HP:0002419)3.51421075
9Abnormality of midbrain morphology (HP:0002418)3.51421075
10Dysmetric saccades (HP:0000641)3.45356946
11Prostate neoplasm (HP:0100787)3.41383496
12Hyperventilation (HP:0002883)3.40997055
13Action tremor (HP:0002345)3.38139568
14Focal seizures (HP:0007359)3.31405081
15Congenital stationary night blindness (HP:0007642)3.23981043
16Abnormality of the renal cortex (HP:0011035)3.17180134
17Dialeptic seizures (HP:0011146)3.15280935
18Abolished electroretinogram (ERG) (HP:0000550)3.14080881
19Attenuation of retinal blood vessels (HP:0007843)3.13293901
20Nephronophthisis (HP:0000090)3.12547091
21Absence seizures (HP:0002121)3.04430528
22Increased corneal curvature (HP:0100692)2.85772918
23Keratoconus (HP:0000563)2.85772918
24Medial flaring of the eyebrow (HP:0010747)2.85202411
25Abnormality of the renal medulla (HP:0100957)2.84115888
26Chronic hepatic failure (HP:0100626)2.78342953
27Polydipsia (HP:0001959)2.76454904
28Abnormal drinking behavior (HP:0030082)2.76454904
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.68565367
30Abnormality of macular pigmentation (HP:0008002)2.68312537
31Febrile seizures (HP:0002373)2.63259503
32Impaired smooth pursuit (HP:0007772)2.60924024
33Focal motor seizures (HP:0011153)2.60405247
34Abnormal rod and cone electroretinograms (HP:0008323)2.58315313
35Bile duct proliferation (HP:0001408)2.55909524
36Abnormal biliary tract physiology (HP:0012439)2.55909524
37Tubular atrophy (HP:0000092)2.55315241
38Clumsiness (HP:0002312)2.55244044
39Fair hair (HP:0002286)2.52597522
40Abnormality of the hepatic vasculature (HP:0006707)2.52060289
41Cystic liver disease (HP:0006706)2.48571202
42Renal cortical cysts (HP:0000803)2.44005401
43Broad-based gait (HP:0002136)2.38767465
44Urinary bladder sphincter dysfunction (HP:0002839)2.36063005
45Protruding tongue (HP:0010808)2.35459625
46Inability to walk (HP:0002540)2.35320102
47Severe visual impairment (HP:0001141)2.35023986
48Bony spicule pigmentary retinopathy (HP:0007737)2.26740367
49Absent speech (HP:0001344)2.26195622
50Abnormality of the prostate (HP:0008775)2.25660496
51Gait imbalance (HP:0002141)2.24736609
52Congenital primary aphakia (HP:0007707)2.21109746
53Chorioretinal atrophy (HP:0000533)2.20578148
54Sclerocornea (HP:0000647)2.19262232
55Tongue fasciculations (HP:0001308)2.18767603
56Dysdiadochokinesis (HP:0002075)2.18239448
57Decreased electroretinogram (ERG) amplitude (HP:0000654)2.17591803
58Progressive inability to walk (HP:0002505)2.17034934
59Postural instability (HP:0002172)2.14287717
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.11395633
61Polyuria (HP:0000103)2.11390297
62Retinitis pigmentosa (HP:0000510)2.09968088
63Aplasia/Hypoplasia of the tibia (HP:0005772)2.09123466
64Limb ataxia (HP:0002070)2.08745820
65Absent/shortened dynein arms (HP:0200106)2.08403128
66Dynein arm defect of respiratory motile cilia (HP:0012255)2.08403128
67Decreased central vision (HP:0007663)2.07876905
68Hypothermia (HP:0002045)2.07833570
69Abnormality of ocular smooth pursuit (HP:0000617)2.02426952
70Hemiparesis (HP:0001269)2.01782230
71Congenital hepatic fibrosis (HP:0002612)2.00770371
72Constricted visual fields (HP:0001133)1.99167866
73Hyperglycinemia (HP:0002154)1.96827606
74Slow saccadic eye movements (HP:0000514)1.96787223
75Hypoproteinemia (HP:0003075)1.96198830
76Oculomotor apraxia (HP:0000657)1.93982402
77Nephrogenic diabetes insipidus (HP:0009806)1.93491946
78Atonic seizures (HP:0010819)1.91326753
79Anencephaly (HP:0002323)1.91173588
80Decreased circulating renin level (HP:0003351)1.90790616
81Congenital sensorineural hearing impairment (HP:0008527)1.89961098
82Hyperglycinuria (HP:0003108)1.89677014
83Generalized hypopigmentation of hair (HP:0011358)1.88465631
84Genital tract atresia (HP:0001827)1.88273103
85Central scotoma (HP:0000603)1.86074346
86Impaired vibratory sensation (HP:0002495)1.80538399
87Oligodactyly (hands) (HP:0001180)1.79806556
88Postaxial foot polydactyly (HP:0001830)1.78781331
89Macular degeneration (HP:0000608)1.77010602
90Ketoacidosis (HP:0001993)1.75645894
91Muscle fibrillation (HP:0010546)1.74795304
92Hypochromic microcytic anemia (HP:0004840)1.73332919
93Abnormal urine output (HP:0012590)1.73271751
94Vaginal atresia (HP:0000148)1.71304658
95Thyroid-stimulating hormone excess (HP:0002925)1.71205325
963-Methylglutaconic aciduria (HP:0003535)1.71128837
97Male pseudohermaphroditism (HP:0000037)1.71022756
98Abnormal ciliary motility (HP:0012262)1.70810838
99Hypoplasia of the fovea (HP:0007750)1.70714876
100Aplasia/Hypoplasia of the fovea (HP:0008060)1.70714876

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.10166948
2CDK193.92999132
3OXSR13.37573000
4BMPR1B2.74110861
5ADRBK22.67982989
6MAP4K22.66699242
7GRK12.61227951
8TXK2.48120745
9INSRR2.46835131
10WNK32.19744250
11ACVR1B2.13841764
12TAOK32.02968535
13PINK12.01110979
14BCR1.81927122
15NUAK11.79532099
16MAP3K41.73630029
17ZAK1.60560942
18CASK1.59015560
19MAPK131.48562651
20BLK1.46797527
21MKNK21.46272684
22WNK41.33575656
23STK391.20921772
24TNK21.17064272
25PIK3CG1.11177210
26TRIM281.10366822
27MUSK1.09072691
28TEC1.03639223
29PAK31.02925858
30MAP2K70.98336076
31STK38L0.97372323
32ADRBK10.96153696
33TIE10.96007571
34MAP3K70.94778289
35TNIK0.93785305
36BCKDK0.92689721
37ERBB30.90758813
38MARK10.90060798
39PLK20.86836290
40MKNK10.85934225
41EPHA40.84694176
42DAPK20.83717561
43PRKCE0.83710459
44PTK2B0.82952349
45NTRK30.82151305
46MAP2K60.80292792
47GRK70.75075205
48TGFBR10.73170933
49FER0.71513470
50STK30.69903513
51KIT0.68493222
52OBSCN0.68338607
53EIF2AK30.66454622
54CSNK1G20.66052723
55TLK10.64474415
56CSNK1G10.63706601
57CAMKK20.62941197
58STK110.60670912
59PRKCG0.58859456
60ITK0.56258916
61EPHA30.55495582
62CSNK1G30.54816338
63MAPKAPK30.51268765
64CAMK2A0.47876223
65PDK20.47456851
66CSNK1A1L0.45491361
67PRKAA20.44587325
68PRKACA0.44188436
69STK380.43536549
70PRKG10.43240265
71PIK3CA0.42852575
72IKBKB0.42556724
73TAF10.40376473
74GRK50.39796900
75BRSK20.36609859
76PRKAA10.36427451
77DYRK20.36078410
78TGFBR20.34333353
79PHKG10.33765785
80PHKG20.33765785
81PRKCQ0.33392094
82ABL10.32914858
83SIK20.32457734
84CSNK1D0.32307479
85MATK0.32058866
86MAPK70.30977728
87IGF1R0.30144515
88CAMK2D0.29857563
89BMPR20.29434363
90PKN10.28889666
91CSNK1A10.28265881
92DYRK1A0.27950038
93SYK0.27199896
94NTRK20.26935249
95MAPKAPK50.26705202
96PRKCA0.25826991
97MAP3K60.25153592
98TRPM70.24896768
99GRK60.24383007
100MST40.22459271

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.76257497
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.90089884
3Linoleic acid metabolism_Homo sapiens_hsa005912.65154096
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.63865721
5Butanoate metabolism_Homo sapiens_hsa006502.62483688
6Phototransduction_Homo sapiens_hsa047442.50811066
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.48863437
8Caffeine metabolism_Homo sapiens_hsa002322.21458191
9Olfactory transduction_Homo sapiens_hsa047402.16392792
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.12544228
11Tryptophan metabolism_Homo sapiens_hsa003802.11284495
12Ether lipid metabolism_Homo sapiens_hsa005652.10293451
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.05946637
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.95991028
15Nicotine addiction_Homo sapiens_hsa050331.93995680
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.85459472
17Retinol metabolism_Homo sapiens_hsa008301.71733254
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.69151323
19RNA polymerase_Homo sapiens_hsa030201.63784891
20Propanoate metabolism_Homo sapiens_hsa006401.62226172
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61864629
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.60900171
23Taste transduction_Homo sapiens_hsa047421.59209457
24Nitrogen metabolism_Homo sapiens_hsa009101.55582460
25ABC transporters_Homo sapiens_hsa020101.51727188
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.51358930
27Fanconi anemia pathway_Homo sapiens_hsa034601.45415235
28Selenocompound metabolism_Homo sapiens_hsa004501.43794962
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33095691
30Morphine addiction_Homo sapiens_hsa050321.33066119
31Homologous recombination_Homo sapiens_hsa034401.32827426
32Chemical carcinogenesis_Homo sapiens_hsa052041.26847729
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.22684530
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22554410
35Circadian rhythm_Homo sapiens_hsa047101.15027197
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11084450
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09325662
38Arachidonic acid metabolism_Homo sapiens_hsa005901.09097053
39Peroxisome_Homo sapiens_hsa041461.08904885
40Glutamatergic synapse_Homo sapiens_hsa047241.06049939
41GABAergic synapse_Homo sapiens_hsa047271.05589558
42Basal transcription factors_Homo sapiens_hsa030221.05583108
43Salivary secretion_Homo sapiens_hsa049701.03521429
44Ovarian steroidogenesis_Homo sapiens_hsa049130.99116449
45Circadian entrainment_Homo sapiens_hsa047130.98436958
46Fatty acid degradation_Homo sapiens_hsa000710.92753858
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90032719
48Protein export_Homo sapiens_hsa030600.87388240
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86846517
50Insulin secretion_Homo sapiens_hsa049110.86824289
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85334791
52Graft-versus-host disease_Homo sapiens_hsa053320.84445326
53Serotonergic synapse_Homo sapiens_hsa047260.83295447
54Fatty acid biosynthesis_Homo sapiens_hsa000610.81500691
55Calcium signaling pathway_Homo sapiens_hsa040200.81016663
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78926012
57beta-Alanine metabolism_Homo sapiens_hsa004100.78910530
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.78321146
59Purine metabolism_Homo sapiens_hsa002300.76378028
60Regulation of autophagy_Homo sapiens_hsa041400.75987806
61Fatty acid metabolism_Homo sapiens_hsa012120.74867443
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.74062896
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71912613
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.70091821
65RNA degradation_Homo sapiens_hsa030180.69355023
66Glycerolipid metabolism_Homo sapiens_hsa005610.68266990
67Renin secretion_Homo sapiens_hsa049240.66053597
68Collecting duct acid secretion_Homo sapiens_hsa049660.65985692
69Dorso-ventral axis formation_Homo sapiens_hsa043200.64657007
70Fat digestion and absorption_Homo sapiens_hsa049750.61610458
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61307874
72cAMP signaling pathway_Homo sapiens_hsa040240.60991468
73One carbon pool by folate_Homo sapiens_hsa006700.60069078
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.59509816
75Primary immunodeficiency_Homo sapiens_hsa053400.56926830
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53612207
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53433591
78Type I diabetes mellitus_Homo sapiens_hsa049400.52338691
79Histidine metabolism_Homo sapiens_hsa003400.52124560
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.51915358
81Metabolic pathways_Homo sapiens_hsa011000.51158981
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.46819945
83Oxidative phosphorylation_Homo sapiens_hsa001900.45987245
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45702173
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44301937
86Sphingolipid metabolism_Homo sapiens_hsa006000.44252819
87Gastric acid secretion_Homo sapiens_hsa049710.42291006
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41850662
89Long-term depression_Homo sapiens_hsa047300.41792909
90Dopaminergic synapse_Homo sapiens_hsa047280.41591046
91Non-homologous end-joining_Homo sapiens_hsa034500.40706938
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40020214
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39453026
94Oxytocin signaling pathway_Homo sapiens_hsa049210.39123135
95PPAR signaling pathway_Homo sapiens_hsa033200.34828119
96Pyrimidine metabolism_Homo sapiens_hsa002400.34568642
97Mineral absorption_Homo sapiens_hsa049780.34443300
98Asthma_Homo sapiens_hsa053100.34026697
99Autoimmune thyroid disease_Homo sapiens_hsa053200.33714809
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31402368

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