WFDC12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water homeostasis (GO:0030104)9.45280292
2epidermal cell differentiation (GO:0009913)8.41171166
3peptide cross-linking (GO:0018149)8.31845697
4desmosome organization (GO:0002934)7.52593114
5skin morphogenesis (GO:0043589)7.40447438
6epidermis development (GO:0008544)7.07941699
7detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)6.94365715
8keratinocyte proliferation (GO:0043616)6.72811771
9detection of bacterium (GO:0016045)6.56957037
10bundle of His cell to Purkinje myocyte communication (GO:0086069)6.33114632
11lipoxygenase pathway (GO:0019372)6.29447022
12detection of other organism (GO:0098543)6.00961346
13surfactant homeostasis (GO:0043129)5.97070465
14regulation of natural killer cell differentiation (GO:0032823)5.40387957
15chemical homeostasis within a tissue (GO:0048875)5.08539810
16phosphatidylinositol acyl-chain remodeling (GO:0036149)4.99034035
17lung secretory cell differentiation (GO:0061140)4.86291051
18lateral sprouting from an epithelium (GO:0060601)4.71484094
19phospholipid efflux (GO:0033700)4.65963075
20negative regulation of interferon-gamma production (GO:0032689)4.63636436
21molting cycle (GO:0042303)4.62837576
22hair cycle (GO:0042633)4.62837576
23gap junction assembly (GO:0016264)4.60066806
24phosphatidylserine acyl-chain remodeling (GO:0036150)4.59417874
25ectoderm development (GO:0007398)4.22499583
26negative regulation of mast cell activation (GO:0033004)4.20607923
27positive regulation of uterine smooth muscle contraction (GO:0070474)4.17272091
28positive regulation of cholesterol efflux (GO:0010875)4.13931539
29keratinization (GO:0031424)4.06915673
30detection of chemical stimulus involved in sensory perception of taste (GO:0050912)4.02286995
31establishment of planar polarity (GO:0001736)4.02253572
32establishment of tissue polarity (GO:0007164)4.02253572
33pattern specification involved in kidney development (GO:0061004)3.98835880
34negative regulation of interleukin-17 production (GO:0032700)3.97694546
35sequestering of metal ion (GO:0051238)3.97016555
36aggressive behavior (GO:0002118)3.93727937
37intermediate filament cytoskeleton organization (GO:0045104)3.88770207
38protein K11-linked deubiquitination (GO:0035871)3.83758065
39phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.79553736
40intermediate filament-based process (GO:0045103)3.77818667
41mesenchymal cell differentiation involved in kidney development (GO:0072161)3.76677724
42mesenchymal cell differentiation involved in renal system development (GO:2001012)3.76677724
43superoxide anion generation (GO:0042554)3.76044404
44pyrimidine dimer repair (GO:0006290)3.72040967
45negative regulation of stem cell proliferation (GO:2000647)3.67726139
46positive regulation of sterol transport (GO:0032373)3.67354105
47positive regulation of cholesterol transport (GO:0032376)3.67354105
48ceramide biosynthetic process (GO:0046513)3.64629673
49polarized epithelial cell differentiation (GO:0030859)3.64564293
50cerebral cortex radially oriented cell migration (GO:0021799)3.63955136
51keratinocyte development (GO:0003334)3.61965907
52detection of molecule of bacterial origin (GO:0032490)3.56132363
53kidney morphogenesis (GO:0060993)3.55492347
54negative regulation of synaptic transmission, GABAergic (GO:0032229)3.48302151
55positive regulation of heat generation (GO:0031652)3.48093642
56phosphatidylcholine acyl-chain remodeling (GO:0036151)3.44511037
57limb bud formation (GO:0060174)3.43793439
58detection of chemical stimulus involved in sensory perception (GO:0050907)3.41479210
59negative regulation of telomere maintenance (GO:0032205)3.41031895
60extracellular regulation of signal transduction (GO:1900115)3.40226918
61extracellular negative regulation of signal transduction (GO:1900116)3.40226918
62regulation of penile erection (GO:0060405)3.39731165
63phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.39455860
64epithelium development (GO:0060429)3.38487066
65prostate gland growth (GO:0060736)3.32195759
66intermediate filament organization (GO:0045109)3.24136895
67central nervous system projection neuron axonogenesis (GO:0021952)3.21487015
68defense response to fungus (GO:0050832)3.15427759
69regulation of monocyte chemotaxis (GO:0090025)3.11484949
70regulation of non-canonical Wnt signaling pathway (GO:2000050)3.05794860
71cell differentiation involved in metanephros development (GO:0072202)3.05715099
72regulation of natural killer cell activation (GO:0032814)3.05007363
73regulation of keratinocyte proliferation (GO:0010837)3.03724962
74regulation of protein localization to cell surface (GO:2000008)3.03583491
75long-chain fatty acid biosynthetic process (GO:0042759)3.01870016
76regulation of neuron projection regeneration (GO:0070570)3.01826207
77regulation of axon regeneration (GO:0048679)3.01826207
78positive regulation by symbiont of host defense response (GO:0052509)2.97278543
79modulation by symbiont of host defense response (GO:0052031)2.97278543
80modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.97278543
81modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.97278543
82positive regulation by organism of defense response of other organism involved in symbiotic interact2.97278543
83modulation by symbiont of host immune response (GO:0052553)2.97278543
84negative regulation of homotypic cell-cell adhesion (GO:0034111)2.95980510
85mammary gland epithelial cell differentiation (GO:0060644)2.95725025
86mesonephros development (GO:0001823)2.92132749
87neural crest cell development (GO:0014032)2.90076983
88nucleotide transmembrane transport (GO:1901679)2.89079060
89muscle filament sliding (GO:0030049)2.86968358
90actin-myosin filament sliding (GO:0033275)2.86968358
91regulation of telomere maintenance (GO:0032204)2.86952254
92negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.85385364
93purine ribonucleotide transport (GO:0015868)2.84996618
94neuron cell-cell adhesion (GO:0007158)2.84168288
95response to host immune response (GO:0052572)2.84025093
96response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.84025093
97negative regulation of keratinocyte proliferation (GO:0010839)2.83512390
98detection of biotic stimulus (GO:0009595)2.82310454
99regulation of cholesterol efflux (GO:0010874)2.82053558
100diterpenoid biosynthetic process (GO:0016102)2.80538781
101adenine nucleotide transport (GO:0051503)2.78690613
102cornea development in camera-type eye (GO:0061303)2.77512449
103regulation of uterine smooth muscle contraction (GO:0070472)2.75453576
104regulation of relaxation of muscle (GO:1901077)2.75388171
105regulation of activation of Janus kinase activity (GO:0010533)2.74026988
106regulation of synaptic transmission, GABAergic (GO:0032228)2.73738695
107defense response to Gram-negative bacterium (GO:0050829)2.71557666
108positive regulation of smooth muscle cell migration (GO:0014911)2.70944896
109phosphatidylserine metabolic process (GO:0006658)2.69915654
110axon ensheathment in central nervous system (GO:0032291)2.66996462
111central nervous system myelination (GO:0022010)2.66996462
112spinal cord development (GO:0021510)2.66518710
113positive regulation of cellular amide metabolic process (GO:0034250)2.66403178
114positive regulation of monocyte chemotaxis (GO:0090026)2.65858404
115production of molecular mediator involved in inflammatory response (GO:0002532)2.65475514
116fatty acid elongation (GO:0030497)2.65247346
117heart process (GO:0003015)2.64865234
118heart contraction (GO:0060047)2.64865234
119metanephric mesenchyme development (GO:0072075)2.62747773
120pyrimidine nucleobase catabolic process (GO:0006208)2.61327768
121sphingolipid biosynthetic process (GO:0030148)2.60863955
122actin-mediated cell contraction (GO:0070252)2.60671138
123linoleic acid metabolic process (GO:0043651)2.59754147
124negative regulation of cardiac muscle hypertrophy (GO:0010614)2.59579125
125phospholipid catabolic process (GO:0009395)2.59518911
126regulation of keratinocyte differentiation (GO:0045616)2.59404249
127viral mRNA export from host cell nucleus (GO:0046784)2.58977753
128response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.57117098
129positive regulation of action potential (GO:0045760)2.56375195
130positive regulation of T cell chemotaxis (GO:0010820)2.56339447
131regulation of T cell chemotaxis (GO:0010819)2.56339447
132embryonic digestive tract morphogenesis (GO:0048557)2.54462591
133fucose catabolic process (GO:0019317)2.54121496
134L-fucose metabolic process (GO:0042354)2.54121496
135L-fucose catabolic process (GO:0042355)2.54121496
136positive regulation of actin filament depolymerization (GO:0030836)2.51904454
137regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.51673876
138regulation of mitotic spindle checkpoint (GO:1903504)2.51673876
139regulation of lymphocyte chemotaxis (GO:1901623)2.51429518
140adrenergic receptor signaling pathway (GO:0071875)2.51401979
141G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.50744044
142urogenital system development (GO:0001655)2.50482123
143T-helper 1 type immune response (GO:0042088)2.50319602
144detection of external biotic stimulus (GO:0098581)2.50123438
145cardiac chamber formation (GO:0003207)2.48495755
146organ growth (GO:0035265)2.48145459
147dendritic cell chemotaxis (GO:0002407)2.47835577
148one-carbon compound transport (GO:0019755)2.45151914
149alditol phosphate metabolic process (GO:0052646)2.44894579
150hydrogen peroxide catabolic process (GO:0042744)2.44163154
151positive regulation of mitochondrial fission (GO:0090141)2.43202882
152hair cell differentiation (GO:0035315)2.43181927
153regulation of heat generation (GO:0031650)2.42635636
154import into cell (GO:0098657)2.41629470
155facial nerve structural organization (GO:0021612)2.41415120
156behavioral response to nicotine (GO:0035095)2.41045529
157sympathetic nervous system development (GO:0048485)2.40739275
158genitalia morphogenesis (GO:0035112)2.40317823
159epithelial cell differentiation involved in prostate gland development (GO:0060742)2.40127443
160ventricular cardiac muscle cell action potential (GO:0086005)2.39610802
161positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.38132054
162establishment of skin barrier (GO:0061436)2.36727625
163multicellular organismal aging (GO:0010259)2.36504867
164serotonin receptor signaling pathway (GO:0007210)2.36413269
165positive regulation of amino acid transport (GO:0051957)2.36171152
166mesenchymal cell development (GO:0014031)2.35517484
167antimicrobial humoral response (GO:0019730)2.32814361
168negative regulation of epidermal cell differentiation (GO:0045605)2.32107147
169smooth muscle tissue development (GO:0048745)2.31610448
170positive regulation of epidermis development (GO:0045684)2.31470999
171regulation of epidermis development (GO:0045682)2.23636371
172epithelial cell differentiation (GO:0030855)2.22527913
173negative regulation of cell aging (GO:0090344)2.21524914
174regulation of interleukin-17 production (GO:0032660)2.19645344
175negative regulation of oligodendrocyte differentiation (GO:0048715)2.17709259
176intestinal epithelial cell development (GO:0060576)2.17381257
177hemidesmosome assembly (GO:0031581)2.16576255
178hair follicle morphogenesis (GO:0031069)2.15926278
179regulation of heart rate by cardiac conduction (GO:0086091)2.15674340
180extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)2.14289854
181signal transduction in absence of ligand (GO:0038034)2.14289854
182negative regulation of astrocyte differentiation (GO:0048712)2.13745963
183regulation of epidermal cell differentiation (GO:0045604)2.11490089
184negative regulation of lymphocyte differentiation (GO:0045620)2.10830626
185skin development (GO:0043588)2.10554987
186positive regulation of granulocyte chemotaxis (GO:0071624)2.09901207
187negative regulation of epidermis development (GO:0045683)2.07382161
188regulation of water loss via skin (GO:0033561)17.8180747
189multicellular organismal water homeostasis (GO:0050891)11.1725722
190keratinocyte differentiation (GO:0030216)10.8291858

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.61031830
2GBX2_23144817_ChIP-Seq_PC3_Human3.23204626
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.05556564
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.93618899
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.68638992
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67445302
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.56935573
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40728713
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29538423
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.26574554
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.25498172
12TP63_23658742_ChIP-Seq_EP156T_Human2.23194095
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19107551
14RXR_22108803_ChIP-Seq_LS180_Human2.00682431
15POU5F1_16153702_ChIP-ChIP_HESCs_Human1.99131779
16BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95088821
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.94766125
18GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.94430937
19P300_19829295_ChIP-Seq_ESCs_Human1.93742962
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92701192
21ER_23166858_ChIP-Seq_MCF-7_Human1.89742771
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87357379
23SUZ12_18555785_Chip-Seq_ESCs_Mouse1.83885676
24TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.81437515
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.79611311
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.79406353
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.76873882
28E2F1_18555785_Chip-Seq_ESCs_Mouse1.76643488
29CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.76438710
30VDR_22108803_ChIP-Seq_LS180_Human1.75833118
31EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.74014373
32SOX9_24532713_ChIP-Seq_HFSC_Mouse1.73382703
33GATA6_21074721_ChIP-Seq_CACO-2_Human1.72462214
34NANOG_18555785_Chip-Seq_ESCs_Mouse1.70741066
35SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.70528700
36SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.70528700
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69953866
38P53_22387025_ChIP-Seq_ESCs_Mouse1.69820846
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.68305510
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66697984
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.66389597
42FUS_26573619_Chip-Seq_HEK293_Human1.66122275
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.65683044
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.64346052
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.62315261
46RNF2_27304074_Chip-Seq_NSC_Mouse1.61377983
47CJUN_26792858_Chip-Seq_BT549_Human1.61332374
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61303153
49CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60055344
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59461390
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.58525115
52CMYC_18555785_Chip-Seq_ESCs_Mouse1.58181247
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.57890752
54STAT3_18555785_Chip-Seq_ESCs_Mouse1.57750630
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.56811257
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.56416056
57TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.56192585
58AR_25329375_ChIP-Seq_VCAP_Human1.52760122
59P53_22127205_ChIP-Seq_FIBROBLAST_Human1.52757387
60AHR_22903824_ChIP-Seq_MCF-7_Human1.52579215
61FOXM1_26456572_ChIP-Seq_MCF-7_Human1.51723676
62EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.51361249
63SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.51063318
64SOX2_18555785_Chip-Seq_ESCs_Mouse1.50518525
65SMAD4_21799915_ChIP-Seq_A2780_Human1.50239816
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.48532786
67SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.48042661
68BCAT_22108803_ChIP-Seq_LS180_Human1.47490165
69P300_18555785_Chip-Seq_ESCs_Mouse1.47203842
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44550557
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.44461982
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43865289
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43053936
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42922337
75TP53_16413492_ChIP-PET_HCT116_Human1.42800485
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42569033
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40840531
78JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40611135
79TCF4_22108803_ChIP-Seq_LS180_Human1.39726215
80OCT4_18555785_Chip-Seq_ESCs_Mouse1.39353360
81IGF1R_20145208_ChIP-Seq_DFB_Human1.39073859
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38738514
83NMYC_18555785_Chip-Seq_ESCs_Mouse1.38344843
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.38157512
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35748165
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35614358
87TAL1_26923725_Chip-Seq_HPCs_Mouse1.34906868
88HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34055720
89* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33104428
90RUNX1_27457419_Chip-Seq_LIVER_Mouse1.32335728
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32171593
92JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31034544
93TAF15_26573619_Chip-Seq_HEK293_Human1.30736004
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29240498
95TCF4_18268006_ChIP-ChIP_LS174T_Human1.29228260
96EWS_26573619_Chip-Seq_HEK293_Human1.29226928
97PU1_27457419_Chip-Seq_LIVER_Mouse1.28681690
98VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.28572384
99ERG_20517297_ChIP-Seq_VCAP_Human1.28421645
100TP53_18474530_ChIP-ChIP_U2OS_Human1.28340288
101RNF2_27304074_Chip-Seq_ESCs_Mouse1.28259184
102ZFX_18555785_Chip-Seq_ESCs_Mouse1.28060851
103CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27928892
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27482017
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27482017
106EGR1_19032775_ChIP-ChIP_M12_Human1.27101413
107ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25957107
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25549946
109CDX2_22108803_ChIP-Seq_LS180_Human1.23815974
110* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.23415225
111EZH2_27294783_Chip-Seq_NPCs_Mouse1.22888491
112FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22819649
113STAT3_23295773_ChIP-Seq_U87_Human1.20627432
114EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19816633
115RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19816633
116NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17655934
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17655934
118CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17537832
119AR_21572438_ChIP-Seq_LNCaP_Human1.17472685
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17375395
121SMAD_19615063_ChIP-ChIP_OVARY_Human1.15863237
122GF1B_26923725_Chip-Seq_HPCs_Mouse1.15793277
123TCF4_23295773_ChIP-Seq_U87_Human1.15608690
124CTCF_18555785_Chip-Seq_ESCs_Mouse1.15153840
125NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14964389
126ARNT_22903824_ChIP-Seq_MCF-7_Human1.14698367
127SMAD3_21741376_ChIP-Seq_EPCs_Human1.13753250
128KLF4_18555785_Chip-Seq_ESCs_Mouse1.12385767
129HNFA_21074721_ChIP-Seq_CACO-2_Human1.11815567
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11350386
131* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09288102
132ESRRB_18555785_Chip-Seq_ESCs_Mouse1.08946684
133EZH2_27294783_Chip-Seq_ESCs_Mouse1.08592826
134HTT_18923047_ChIP-ChIP_STHdh_Human1.08381671
135SMAD3_21741376_ChIP-Seq_HESCs_Human1.08337091
136* TP63_22573176_ChIP-Seq_HFKS_Human1.08200679
137ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07423177
138CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07230189
139KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06947919
140RBPJ_21746931_ChIP-Seq_IB4_Human1.05158370
141GATA3_24758297_ChIP-Seq_MCF-7_Human1.04892133
142CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.04536783
143SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01716333
144FOXO3_23340844_ChIP-Seq_DLD1_Human1.01602282
145PRDM14_20953172_ChIP-Seq_ESCs_Human1.01401483
146SMAD3_21741376_ChIP-Seq_ESCs_Human1.01171678
147GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99694555
148CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98822211
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95864098
150GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94980974
151ESR1_21235772_ChIP-Seq_MCF-7_Human0.93828436
152AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91702158
153NCOR_22424771_ChIP-Seq_293T_Human0.91301824
154PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.91280842
155CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90889061
156CBP_20019798_ChIP-Seq_JUKART_Human0.90706169
157IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90706169
158SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90402574
159SOX2_20726797_ChIP-Seq_SW620_Human0.90283419
160OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89621487
161TBL1_22424771_ChIP-Seq_293T_Human0.87262376

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.07156199
2MP0010234_abnormal_vibrissa_follicle3.65634077
3MP0003787_abnormal_imprinting3.60347523
4MP0000537_abnormal_urethra_morphology3.56536569
5MP0003191_abnormal_cellular_cholesterol3.52201099
6MP0003878_abnormal_ear_physiology3.37854830
7MP0005377_hearing/vestibular/ear_phenot3.37854830
8MP0002277_abnormal_respiratory_mucosa3.08269180
9MP0005171_absent_coat_pigmentation3.02473144
10MP0002009_preneoplasia2.96341542
11MP0001216_abnormal_epidermal_layer2.92682124
12MP0000015_abnormal_ear_pigmentation2.91908705
13MP0001188_hyperpigmentation2.60128460
14MP0009697_abnormal_copulation2.60128435
15MP0000566_synostosis2.52914340
16MP0004947_skin_inflammation2.35443592
17MP0010678_abnormal_skin_adnexa2.27902712
18MP0006292_abnormal_olfactory_placode2.26339385
19MP0005451_abnormal_body_composition2.24031413
20MP0002102_abnormal_ear_morphology2.21764161
21MP0002938_white_spotting2.14448820
22MP0005670_abnormal_white_adipose2.11513397
23MP0002095_abnormal_skin_pigmentation2.04150207
24MP0003453_abnormal_keratinocyte_physiol2.03281407
25MP0001881_abnormal_mammary_gland2.00928323
26MP0005645_abnormal_hypothalamus_physiol1.95730582
27MP0003121_genomic_imprinting1.93609041
28MP0005367_renal/urinary_system_phenotyp1.90964503
29MP0000516_abnormal_urinary_system1.90964503
30MP0000377_abnormal_hair_follicle1.90880756
31MP0004381_abnormal_hair_follicle1.90335130
32MP0005075_abnormal_melanosome_morpholog1.87804817
33MP0003315_abnormal_perineum_morphology1.85408219
34MP0005409_darkened_coat_color1.83027184
35MP0003122_maternal_imprinting1.80776854
36MP0010386_abnormal_urinary_bladder1.75519193
37MP0002735_abnormal_chemical_nociception1.73614721
38MP0001191_abnormal_skin_condition1.73526412
39MP0002796_impaired_skin_barrier1.64137513
40MP0001177_atelectasis1.62252735
41MP0000538_abnormal_urinary_bladder1.61652447
42MP0001529_abnormal_vocalization1.61405123
43MP0004145_abnormal_muscle_electrophysio1.61162447
44MP0004264_abnormal_extraembryonic_tissu1.60513230
45MP0002822_catalepsy1.58912776
46MP0009931_abnormal_skin_appearance1.57345533
47MP0006276_abnormal_autonomic_nervous1.56409360
48MP0000372_irregular_coat_pigmentation1.53495027
49MP0000569_abnormal_digit_pigmentation1.50966450
50MP0002638_abnormal_pupillary_reflex1.49409065
51MP0000579_abnormal_nail_morphology1.47159396
52MP0001346_abnormal_lacrimal_gland1.45677958
53MP0004147_increased_porphyrin_level1.44539401
54MP0010030_abnormal_orbit_morphology1.44045140
55MP0005248_abnormal_Harderian_gland1.39118145
56MP0005646_abnormal_pituitary_gland1.38760739
57MP0003718_maternal_effect1.36393301
58MP0000427_abnormal_hair_cycle1.32333119
59MP0002249_abnormal_larynx_morphology1.31058075
60MP0000762_abnormal_tongue_morphology1.26223250
61MP0005501_abnormal_skin_physiology1.24850905
62MP0002098_abnormal_vibrissa_morphology1.19665982
63MP0010352_gastrointestinal_tract_polyps1.19406141
64MP0008007_abnormal_cellular_replicative1.19038358
65MP0003011_delayed_dark_adaptation1.15707731
66MP0000467_abnormal_esophagus_morphology1.14655713
67MP0004782_abnormal_surfactant_physiolog1.14281848
68MP0000778_abnormal_nervous_system1.10455502
69MP0005257_abnormal_intraocular_pressure1.08389897
70MP0004130_abnormal_muscle_cell1.08135990
71MP0001784_abnormal_fluid_regulation1.06182233
72MP0002177_abnormal_outer_ear1.05771507
73MP0001984_abnormal_olfaction1.05172802
74MP0002138_abnormal_hepatobiliary_system1.03601459
75MP0003890_abnormal_embryonic-extraembry1.02694873
76MP0008058_abnormal_DNA_repair1.01826989
77MP0000367_abnormal_coat/_hair1.01807279
78MP0001186_pigmentation_phenotype1.01184775
79MP0005275_abnormal_skin_tensile1.00783302
80MP0005499_abnormal_olfactory_system0.99866071
81MP0005394_taste/olfaction_phenotype0.99866071
82MP0003941_abnormal_skin_development0.98704341
83MP0001919_abnormal_reproductive_system0.97080419
84MP0004019_abnormal_vitamin_homeostasis0.96162491
85MP0008789_abnormal_olfactory_epithelium0.94531015
86MP0009250_abnormal_appendicular_skeleto0.93279250
87MP0001485_abnormal_pinna_reflex0.92320757
88MP0002075_abnormal_coat/hair_pigmentati0.92305900
89MP0000383_abnormal_hair_follicle0.92196835
90MP0004885_abnormal_endolymph0.91343038
91MP0000049_abnormal_middle_ear0.90194474
92MP0004924_abnormal_behavior0.89747711
93MP0005386_behavior/neurological_phenoty0.89747711
94MP0002557_abnormal_social/conspecific_i0.88318257
95MP0000465_gastrointestinal_hemorrhage0.86666859
96MP0009764_decreased_sensitivity_to0.86652224
97MP0003828_pulmonary_edema0.85547471
98MP0001324_abnormal_eye_pigmentation0.84768033
99MP0008775_abnormal_heart_ventricle0.83193025
100MP0010771_integument_phenotype0.82111131
101MP0000627_abnormal_mammary_gland0.81947492
102MP0000749_muscle_degeneration0.80873450
103MP0003385_abnormal_body_wall0.77412033
104MP0002060_abnormal_skin_morphology0.76866215
105MP0004134_abnormal_chest_morphology0.74862361
106MP0003755_abnormal_palate_morphology0.74634711
107MP0002148_abnormal_hypersensitivity_rea0.74521796
108MP0002736_abnormal_nociception_after0.74042047
109MP0005408_hypopigmentation0.73677462
110MP0001835_abnormal_antigen_presentation0.73192529
111MP0002972_abnormal_cardiac_muscle0.72442847
112MP0003186_abnormal_redox_activity0.71651675
113MP0002876_abnormal_thyroid_physiology0.71193599
114MP0002234_abnormal_pharynx_morphology0.69514173
115MP0000647_abnormal_sebaceous_gland0.69340782
116MP0001270_distended_abdomen0.68590275
117MP0003123_paternal_imprinting0.68553084
118MP0002006_tumorigenesis0.67369202
119MP0003566_abnormal_cell_adhesion0.66847509
120MP0005503_abnormal_tendon_morphology0.65522723
121MP0003950_abnormal_plasma_membrane0.64948665
122MP0009765_abnormal_xenobiotic_induced0.64570227
123MP0001243_abnormal_dermal_layer0.60140641
124MP0009053_abnormal_anal_canal0.58437507
125MP0005174_abnormal_tail_pigmentation0.55553385
126MP0001851_eye_inflammation0.54689889
127MP0003705_abnormal_hypodermis_morpholog0.48531982
128MP0008057_abnormal_DNA_replication0.42506928
129MP0004185_abnormal_adipocyte_glucose0.40234201
130MP0003183_abnormal_peptide_metabolism0.35866405
131MP0005388_respiratory_system_phenotype0.35253268
132MP0002133_abnormal_respiratory_system0.35253268
133MP0005023_abnormal_wound_healing0.32389372
134MP0002697_abnormal_eye_size0.30431727
135MP0009672_abnormal_birth_weight0.29559546
136MP0002282_abnormal_trachea_morphology0.27849747
137MP0003633_abnormal_nervous_system0.27391914
138MP0004043_abnormal_pH_regulation0.27123808
139MP0004197_abnormal_fetal_growth/weight/0.25338052
140MP0001340_abnormal_eyelid_morphology0.23930440
141MP0001286_abnormal_eye_development0.21291861
142MP0003638_abnormal_response/metabolism_0.19933817
143MP0009115_abnormal_fat_cell0.18304732
144MP0003045_fibrosis0.18246065
145MP0000026_abnormal_inner_ear0.17277722
146MP0008569_lethality_at_weaning0.17115611
147MP0000432_abnormal_head_morphology0.15991668
148MP0009384_cardiac_valve_regurgitation0.14874226
149MP0002653_abnormal_ependyma_morphology0.14299211
150MP0005647_abnormal_sex_gland0.11139082
151MP0001756_abnormal_urination0.10992482
152MP0003631_nervous_system_phenotype0.10711197
153MP0002111_abnormal_tail_morphology0.10475387
154MP0006072_abnormal_retinal_apoptosis0.09799828
155MP0001905_abnormal_dopamine_level0.09592304
156MP0005551_abnormal_eye_electrophysiolog0.09311126
157MP0002168_other_aberrant_phenotype0.09276571
158MP0006138_congestive_heart_failure0.09042205
159MP0001879_abnormal_lymphatic_vessel0.07865092
160MP0002233_abnormal_nose_morphology0.07654113
161MP0000371_diluted_coat_color0.07477177
162MP0008004_abnormal_stomach_pH0.07456679
163MP0005253_abnormal_eye_physiology0.06443598
164MP0002108_abnormal_muscle_morphology0.05469331
165MP0001501_abnormal_sleep_pattern0.05426181

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.06140738
2Congenital nonbullous ichthyosiform erythroderma (HP:0007479)8.30141526
3Congenital ichthyosiform erythroderma (HP:0007431)8.16361162
4Erythroderma (HP:0001019)7.45859676
5Palmoplantar hyperkeratosis (HP:0000972)7.43463427
6Palmar hyperkeratosis (HP:0010765)7.12585982
7Prostate neoplasm (HP:0100787)6.53587707
8Corneal erosion (HP:0200020)6.31199101
9Parakeratosis (HP:0001036)5.94751927
10Hypotrichosis (HP:0001006)5.86305011
11Plantar hyperkeratosis (HP:0007556)5.84643593
12Erythema (HP:0010783)5.31618506
13Calf muscle hypertrophy (HP:0008981)4.77074587
14Gangrene (HP:0100758)4.64755165
15Absent eyelashes (HP:0000561)4.21321392
16Palmoplantar keratoderma (HP:0000982)4.17576549
17Muscle hypertrophy of the lower extremities (HP:0008968)3.99597883
18Furrowed tongue (HP:0000221)3.81946343
19Abnormality of the axillary hair (HP:0100134)3.78578146
20Abnormality of secondary sexual hair (HP:0009888)3.78578146
21Right ventricular cardiomyopathy (HP:0011663)3.71368793
22Sparse eyelashes (HP:0000653)3.65855320
23Tented upper lip vermilion (HP:0010804)3.61497595
24Abnormality of incisor morphology (HP:0011063)3.35651002
25Nail dystrophy (HP:0008404)3.33294730
26Renal cortical cysts (HP:0000803)3.26804872
27Testicular atrophy (HP:0000029)3.15441244
28Pruritus (HP:0000989)3.13367944
29Abnormality of nail color (HP:0100643)3.09852289
30Pustule (HP:0200039)3.08614622
31Gonadotropin excess (HP:0000837)3.06993330
32Rimmed vacuoles (HP:0003805)3.03705204
33Abnormality of the calf musculature (HP:0001430)3.03349958
34Sparse scalp hair (HP:0002209)3.03239037
35Bell-shaped thorax (HP:0001591)3.01112218
36Morphological abnormality of the middle ear (HP:0008609)3.00814319
37Conjunctival hamartoma (HP:0100780)2.91191319
38Progressive sensorineural hearing impairment (HP:0000408)2.88993314
39Alopecia of scalp (HP:0002293)2.88949411
40Amniotic constriction ring (HP:0009775)2.87774339
41Abnormality of placental membranes (HP:0011409)2.87774339
42Abnormal hair whorl (HP:0010721)2.85994870
43Autoamputation (HP:0001218)2.81800167
44Lack of skin elasticity (HP:0100679)2.75256636
45Abnormality of the prostate (HP:0008775)2.73884781
46Woolly hair (HP:0002224)2.73456492
47Distal lower limb muscle weakness (HP:0009053)2.71665331
48Follicular hyperkeratosis (HP:0007502)2.70634008
49Hypoplastic labia majora (HP:0000059)2.68159954
50Chromosomal breakage induced by crosslinking agents (HP:0003221)2.66219912
51Ectropion (HP:0000656)2.62269438
52Blepharitis (HP:0000498)2.59563831
53White forelock (HP:0002211)2.59535736
54Absent hair (HP:0002298)2.58394405
55Thick nail (HP:0001805)2.57901282
56Hypoplastic left heart (HP:0004383)2.55105021
57Febrile seizures (HP:0002373)2.54373643
58Hypothermia (HP:0002045)2.52988115
59Asymmetry of the thorax (HP:0001555)2.51266678
60Chromsome breakage (HP:0040012)2.51255239
61Abnormality of the aortic arch (HP:0012303)2.48593612
62Hypoplasia of the fovea (HP:0007750)2.44500374
63Aplasia/Hypoplasia of the fovea (HP:0008060)2.44500374
64Abnormality of the labia majora (HP:0012881)2.42129765
65Alveolar cell carcinoma (HP:0006519)2.41524759
66Aplasia cutis congenita (HP:0001057)2.40773296
67Hypoplastic heart (HP:0001961)2.38354382
68Hyperventilation (HP:0002883)2.37935319
69Oral leukoplakia (HP:0002745)2.36925150
70Onycholysis (HP:0001806)2.36141660
71Eczematoid dermatitis (HP:0000976)2.35901033
72Brittle hair (HP:0002299)2.33406642
73Patchy hypopigmentation of hair (HP:0011365)2.31217365
74Osteomalacia (HP:0002749)2.30473546
75Neonatal hypoglycemia (HP:0001998)2.30258133
76Fair hair (HP:0002286)2.27681367
77Abnormality of the salivary glands (HP:0010286)2.27233533
78Neoplasm of the tracheobronchial system (HP:0100552)2.26924667
79Polyphagia (HP:0002591)2.25679034
80Dehydration (HP:0001944)2.23723519
81Protruding tongue (HP:0010808)2.17727329
82Hamartoma of the eye (HP:0010568)2.16626398
83Cupped ear (HP:0000378)2.15816557
84Split foot (HP:0001839)2.14984666
85Abnormality of the renal cortex (HP:0011035)2.13782902
86Urticaria (HP:0001025)2.13161402
87Anhidrosis (HP:0000970)2.12750423
88Hypergammaglobulinemia (HP:0010702)2.11783091
89Abnormal hair laboratory examination (HP:0003328)2.07480721
90Recurrent corneal erosions (HP:0000495)2.04990600
91Multifactorial inheritance (HP:0001426)2.04340938
92Blue irides (HP:0000635)2.04300431
93Selective tooth agenesis (HP:0001592)2.04193726
94Azoospermia (HP:0000027)2.02534375
95Palpebral edema (HP:0100540)2.00600345
96Depressed nasal tip (HP:0000437)2.00125716
97Generalized hypopigmentation of hair (HP:0011358)1.96722605
98Fragile nails (HP:0001808)1.96634712
99Abnormality of the nasal septum (HP:0000419)1.95313005
100Bulbar palsy (HP:0001283)1.94308272
101Keratoconjunctivitis (HP:0001096)1.92333446
102True hermaphroditism (HP:0010459)1.90802564
103Nemaline bodies (HP:0003798)1.90439011
104Abnormality of the nasolacrimal system (HP:0000614)1.88273302
105Septate vagina (HP:0001153)1.88098892
106Focal motor seizures (HP:0011153)1.87802970
107Abnormal blistering of the skin (HP:0008066)1.87448850
108Dry skin (HP:0000958)1.86775600
109Septo-optic dysplasia (HP:0100842)1.85268352
110Abnormality of the intervertebral disk (HP:0005108)1.85241857
111Exercise-induced myalgia (HP:0003738)1.83786891
112Nasolacrimal duct obstruction (HP:0000579)1.80745260
113Keratoconjunctivitis sicca (HP:0001097)1.80586728
114Pheochromocytoma (HP:0002666)1.80460414
115Laryngomalacia (HP:0001601)1.79832116
116Lip pit (HP:0100267)1.79814059
117Sepsis (HP:0100806)1.78965824
118Malignant hyperthermia (HP:0002047)1.78251487
119Abnormality of the renal collecting system (HP:0004742)1.76758578
120Exotropia (HP:0000577)1.76471259
121Curly hair (HP:0002212)1.75952998
122Abnormality of the lacrimal duct (HP:0011481)1.75898701
123Fine hair (HP:0002213)1.75545690
124Fibular aplasia (HP:0002990)1.75431318
125Hypohidrosis (HP:0000966)1.74107295
126Neuroendocrine neoplasm (HP:0100634)1.73832576
127Abnormality of the columella (HP:0009929)1.73602162
128Open mouth (HP:0000194)1.72602436
129Aplasia of the musculature (HP:0100854)1.71921130
130Hypoplasia of the iris (HP:0007676)1.71885165
131Melanocytic nevus (HP:0000995)1.71258821
132Preauricular skin tag (HP:0000384)1.69908242
133Hypochromic microcytic anemia (HP:0004840)1.68133877
134Recurrent bacterial skin infections (HP:0005406)1.67426463
135Abnormality of hair growth rate (HP:0011363)1.65910681
136Slow-growing hair (HP:0002217)1.65910681
137Meningioma (HP:0002858)1.65712950
138Labial hypoplasia (HP:0000066)1.65614554
139Renal dysplasia (HP:0000110)1.65594177
140Increased IgM level (HP:0003496)1.65064439
141Oligodontia (HP:0000677)1.64985434
142Absent eyebrow (HP:0002223)1.63612980
143Abnormality of the ileum (HP:0001549)1.63610360
144Paralysis (HP:0003470)1.63553989
145Progressive hearing impairment (HP:0001730)1.63315853
146Hyperphosphatemia (HP:0002905)1.62878398
147Weak cry (HP:0001612)1.62857722
148Abnormality of male internal genitalia (HP:0000022)1.62182851
149Duplicated collecting system (HP:0000081)1.60735515
150Mesomelia (HP:0003027)1.60505368
151Abnormal biliary tract physiology (HP:0012439)1.60100184
152Bile duct proliferation (HP:0001408)1.60100184
153Optic nerve hypoplasia (HP:0000609)1.60061460
154Centrally nucleated skeletal muscle fibers (HP:0003687)1.59813773
155Aplasia involving bones of the extremities (HP:0009825)1.59806937
156Aplasia involving bones of the upper limbs (HP:0009823)1.59806937
157Aplasia of the phalanges of the hand (HP:0009802)1.59806937
158Premature loss of primary teeth (HP:0006323)1.59293267
159Germ cell neoplasia (HP:0100728)1.58547392
160Neoplasm of the peripheral nervous system (HP:0100007)1.58117814
161Hypoplastic female external genitalia (HP:0012815)1.51678807
162Hypoplastic toenails (HP:0001800)1.51426207
163Skin tags (HP:0010609)1.51348590
164Breast hypoplasia (HP:0003187)1.48866961
165Corneal dystrophy (HP:0001131)1.48295868
166Hyperhidrosis (HP:0000975)1.48127341
167Everted lower lip vermilion (HP:0000232)1.46147373
168Asthma (HP:0002099)1.43809313
169Abnormality of the dental pulp (HP:0006479)1.43385644
170Xerostomia (HP:0000217)1.42712811
171Conical tooth (HP:0000698)1.39517848
172Recurrent skin infections (HP:0001581)1.39005508
173Natal tooth (HP:0000695)1.38571466
174Abnormality of permanent molar morphology (HP:0011071)1.37900124
175Abnormality of the dental root (HP:0006486)1.37900124
176Taurodontia (HP:0000679)1.37900124
177Clubbing of toes (HP:0100760)1.37539962
178Carious teeth (HP:0000670)1.37461247
179Generalized hyperpigmentation (HP:0007440)1.36576501
180Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.36349670
181Hypoplastic nipples (HP:0002557)1.33440324

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR16.93038675
2FRK5.08489905
3TNK24.13060695
4MKNK24.10968596
5CASK3.67147142
6TNIK3.61059303
7FGFR12.66439076
8PIK3CA2.64560191
9ZAK2.61795015
10MKNK12.57189924
11OBSCN2.45204315
12YES12.43744462
13ERBB32.42215440
14FER2.34929339
15MAP2K72.33887804
16EPHA22.28778079
17IRAK32.26922227
18PNCK2.17558784
19PRPF4B2.01821296
20SIK31.89853062
21WNK31.85466543
22MAPKAPK31.84940503
23STK38L1.83421688
24AKT31.82572331
25ADRBK21.81339914
26MARK11.75016813
27WNK41.68459368
28BMPR21.67562536
29TRPM71.58836496
30IRAK21.52332040
31MET1.51244620
32MAP3K91.49078753
33BCR1.47053589
34BMPR1B1.46597655
35EPHB21.44554657
36SGK21.43625170
37TXK1.39184157
38DYRK21.34314892
39LIMK11.28885236
40MAPK131.27925449
41MYLK1.20694268
42STK241.20462972
43EPHA31.16352633
44PDK21.12715909
45PLK21.12351730
46MAP3K141.11925881
47EIF2AK31.10958241
48MAP3K41.06831581
49MAP3K21.05423793
50RIPK11.04841936
51NTRK31.01210958
52IKBKB0.94832166
53ADRBK10.94632914
54SGK2230.93020890
55SGK4940.93020890
56NEK60.91246856
57NME20.90193148
58LATS10.89977244
59STK160.88587185
60MAP4K20.87676153
61PBK0.87369306
62IRAK40.86695506
63NEK90.84832558
64ACVR1B0.84826916
65EPHA40.83276482
66PINK10.82411510
67SGK30.80374444
68GRK70.80149571
69TBK10.79296014
70MAPK150.77970566
71TEC0.77747641
72GRK60.77495651
73TGFBR20.75234859
74EIF2AK20.75101786
75VRK10.73879605
76MST40.73559306
77MAP2K40.71815703
78MAPKAPK50.71731537
79BRD40.69458058
80RPS6KB10.68366179
81BLK0.67041003
82RPS6KC10.65994399
83RPS6KL10.65994399
84CHUK0.64545453
85RPS6KA60.63574060
86CDK30.63383606
87CAMK1G0.61363394
88INSRR0.61164996
89PRKCE0.61143815
90PIK3CG0.60935612
91RPS6KA20.60490559
92MARK30.58628984
93MAPKAPK20.57313592
94CDK80.56948538
95EPHB10.55690138
96GRK10.54710822
97ABL10.54692477
98WNK10.53920001
99DMPK0.53686422
100PTK2B0.52997015
101SRPK10.52333963
102IRAK10.51668105
103MAP3K70.48718984
104IKBKE0.48097737
105ITK0.48080716
106NTRK20.47511955
107BRSK20.46578483
108PRKCZ0.46403531
109STK380.45476046
110PRKAA20.45397456
111BRAF0.45279444
112PAK30.45005093
113MST1R0.44364337
114MAP2K10.43517014
115PDGFRB0.43412430
116PKN10.43384010
117SGK10.43361374
118IGF1R0.42837206
119FLT30.42471769
120MAP3K30.41437583
121CAMK2A0.39035111
122ERBB40.39001120
123EIF2AK10.38390890
124MAPK80.36381236
125FGFR30.36196794
126JAK30.36109980
127PLK30.35541047
128BCKDK0.35477785
129STK30.35241691
130CSNK1A1L0.34454875
131PRKCG0.33587817
132FGFR20.32831414
133MAP2K60.32480747
134MAPK70.32464250
135CLK10.32245614
136MAPK30.32029470
137KIT0.31908225
138ERN10.31232660
139ABL20.30722016
140GSK3A0.30038771
141NLK0.28428907
142MAP3K60.27994347
143TAOK30.27777647
144ROCK10.27251304
145CAMK10.25758457
146PRKACA0.25722293
147STK390.24833217
148CAMK1D0.24373092
149PRKG10.23347851
150TIE10.22913415

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.86927206
2Phototransduction_Homo sapiens_hsa047443.85842545
3Sphingolipid metabolism_Homo sapiens_hsa006002.67091942
4ABC transporters_Homo sapiens_hsa020102.35904780
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.24097232
6Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047502.21814136
7beta-Alanine metabolism_Homo sapiens_hsa004102.17890718
8Arachidonic acid metabolism_Homo sapiens_hsa005902.12103064
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.09162885
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.08370892
11Fatty acid elongation_Homo sapiens_hsa000622.03331101
12Renin secretion_Homo sapiens_hsa049242.01153104
13Fatty acid biosynthesis_Homo sapiens_hsa000611.90948278
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.90274525
15Serotonergic synapse_Homo sapiens_hsa047261.84812183
16Circadian rhythm_Homo sapiens_hsa047101.78844825
17GnRH signaling pathway_Homo sapiens_hsa049121.78071079
18Fanconi anemia pathway_Homo sapiens_hsa034601.67931031
19Vascular smooth muscle contraction_Homo sapiens_hsa042701.65050340
20Rheumatoid arthritis_Homo sapiens_hsa053231.64157933
21Dorso-ventral axis formation_Homo sapiens_hsa043201.63278470
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59097470
23Phenylalanine metabolism_Homo sapiens_hsa003601.58495979
24Measles_Homo sapiens_hsa051621.55752786
25Autoimmune thyroid disease_Homo sapiens_hsa053201.54550023
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.51771139
27Oxidative phosphorylation_Homo sapiens_hsa001901.45880977
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43250958
29Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.42882058
30Phagosome_Homo sapiens_hsa041451.42280096
31Propanoate metabolism_Homo sapiens_hsa006401.42253805
32Melanoma_Homo sapiens_hsa052181.40140174
33Type I diabetes mellitus_Homo sapiens_hsa049401.39382706
34Prolactin signaling pathway_Homo sapiens_hsa049171.37934311
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.34086517
36Leishmaniasis_Homo sapiens_hsa051401.31100029
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.29141819
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25886693
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.21806358
40Choline metabolism in cancer_Homo sapiens_hsa052311.19246333
41Tyrosine metabolism_Homo sapiens_hsa003501.19019904
42Allograft rejection_Homo sapiens_hsa053301.16610230
43Graft-versus-host disease_Homo sapiens_hsa053321.15608513
44Glioma_Homo sapiens_hsa052141.15558791
45Pertussis_Homo sapiens_hsa051331.15424326
46Glycerophospholipid metabolism_Homo sapiens_hsa005641.14138487
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11155102
48Proteasome_Homo sapiens_hsa030501.10664724
49Taste transduction_Homo sapiens_hsa047421.08804818
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08273323
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08187278
52Ether lipid metabolism_Homo sapiens_hsa005651.07848982
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.06292837
54Ras signaling pathway_Homo sapiens_hsa040141.05387021
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01215541
56Gastric acid secretion_Homo sapiens_hsa049710.99273627
57Oxytocin signaling pathway_Homo sapiens_hsa049210.98857936
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98545161
59Influenza A_Homo sapiens_hsa051640.98222718
60Peroxisome_Homo sapiens_hsa041460.97854262
61VEGF signaling pathway_Homo sapiens_hsa043700.96309983
62Salmonella infection_Homo sapiens_hsa051320.95635662
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95576927
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95063231
65Collecting duct acid secretion_Homo sapiens_hsa049660.93755834
66Herpes simplex infection_Homo sapiens_hsa051680.93244075
67Estrogen signaling pathway_Homo sapiens_hsa049150.93098973
68Calcium signaling pathway_Homo sapiens_hsa040200.92238099
69Axon guidance_Homo sapiens_hsa043600.91826319
70Parkinsons disease_Homo sapiens_hsa050120.91284389
71Cardiac muscle contraction_Homo sapiens_hsa042600.91041296
72Alzheimers disease_Homo sapiens_hsa050100.90616150
73Hepatitis C_Homo sapiens_hsa051600.90588875
74Glutamatergic synapse_Homo sapiens_hsa047240.90449584
75TGF-beta signaling pathway_Homo sapiens_hsa043500.89755437
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.89682826
77Amoebiasis_Homo sapiens_hsa051460.89115299
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.88682221
79Tuberculosis_Homo sapiens_hsa051520.88197342
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83603492
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83587854
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82827139
83Dilated cardiomyopathy_Homo sapiens_hsa054140.81932871
84Amphetamine addiction_Homo sapiens_hsa050310.81647302
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81449617
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80500326
87p53 signaling pathway_Homo sapiens_hsa041150.79932256
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78860593
89TNF signaling pathway_Homo sapiens_hsa046680.78125495
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77782120
91Circadian entrainment_Homo sapiens_hsa047130.77684032
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76423848
93Homologous recombination_Homo sapiens_hsa034400.75712180
94Legionellosis_Homo sapiens_hsa051340.74003068
95Platelet activation_Homo sapiens_hsa046110.72942663
96cAMP signaling pathway_Homo sapiens_hsa040240.72420269
97Salivary secretion_Homo sapiens_hsa049700.72123951
98Long-term depression_Homo sapiens_hsa047300.71739256
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71624590
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.71073997
101Long-term potentiation_Homo sapiens_hsa047200.70631501
102Fatty acid metabolism_Homo sapiens_hsa012120.69837782
103Nitrogen metabolism_Homo sapiens_hsa009100.69619314
104Basal transcription factors_Homo sapiens_hsa030220.68219654
105Toxoplasmosis_Homo sapiens_hsa051450.68170130
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67442625
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.67425677
108Steroid biosynthesis_Homo sapiens_hsa001000.66827032
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66001814
110Huntingtons disease_Homo sapiens_hsa050160.65812414
111Hedgehog signaling pathway_Homo sapiens_hsa043400.64418511
112Fat digestion and absorption_Homo sapiens_hsa049750.63984123
113Melanogenesis_Homo sapiens_hsa049160.63843949
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62867934
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61364996
116Dopaminergic synapse_Homo sapiens_hsa047280.60956579
117Nucleotide excision repair_Homo sapiens_hsa034200.60630131
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59578422
119Linoleic acid metabolism_Homo sapiens_hsa005910.56869204
120ErbB signaling pathway_Homo sapiens_hsa040120.56814738
121Endometrial cancer_Homo sapiens_hsa052130.56150691
122Glycerolipid metabolism_Homo sapiens_hsa005610.55958281
123Adherens junction_Homo sapiens_hsa045200.55355276
124Tight junction_Homo sapiens_hsa045300.55340807
125Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52242512
126Morphine addiction_Homo sapiens_hsa050320.51500052
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51302809
128Olfactory transduction_Homo sapiens_hsa047400.50932964
129Staphylococcus aureus infection_Homo sapiens_hsa051500.49399105
130Protein export_Homo sapiens_hsa030600.48969771
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.47850869
132Glucagon signaling pathway_Homo sapiens_hsa049220.47197692
133PPAR signaling pathway_Homo sapiens_hsa033200.46802299
134Hematopoietic cell lineage_Homo sapiens_hsa046400.45773085
135African trypanosomiasis_Homo sapiens_hsa051430.45330727
136Prostate cancer_Homo sapiens_hsa052150.44276543
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44250374
138Retinol metabolism_Homo sapiens_hsa008300.44230891
139Acute myeloid leukemia_Homo sapiens_hsa052210.42929410
140Butanoate metabolism_Homo sapiens_hsa006500.42724563
141Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42562646
142Ovarian steroidogenesis_Homo sapiens_hsa049130.42553696
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41652907
144Inositol phosphate metabolism_Homo sapiens_hsa005620.40133189
145Hippo signaling pathway_Homo sapiens_hsa043900.39880464
146Histidine metabolism_Homo sapiens_hsa003400.39119442
147Mineral absorption_Homo sapiens_hsa049780.38980068
148Pancreatic secretion_Homo sapiens_hsa049720.38691347
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.37938230
150Arginine biosynthesis_Homo sapiens_hsa002200.36345695
151Jak-STAT signaling pathway_Homo sapiens_hsa046300.36207059
152Nicotine addiction_Homo sapiens_hsa050330.35016204
153MicroRNAs in cancer_Homo sapiens_hsa052060.34773353
154ECM-receptor interaction_Homo sapiens_hsa045120.34697843
155Cholinergic synapse_Homo sapiens_hsa047250.31426328
156Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31254032
157Rap1 signaling pathway_Homo sapiens_hsa040150.31066841
158MAPK signaling pathway_Homo sapiens_hsa040100.30300231
159Basal cell carcinoma_Homo sapiens_hsa052170.26766438
160Chemical carcinogenesis_Homo sapiens_hsa052040.25865742
161Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20735036
162Oocyte meiosis_Homo sapiens_hsa041140.20711389
163Insulin signaling pathway_Homo sapiens_hsa049100.20711190
164Complement and coagulation cascades_Homo sapiens_hsa046100.20087199
165Tryptophan metabolism_Homo sapiens_hsa003800.17243733

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