WFDC13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of clathrin-mediated endocytosis (GO:2000369)8.16013846
2positive regulation of antigen processing and presentation (GO:0002579)7.62740021
3regulation of acrosome reaction (GO:0060046)6.47588018
4regulation of antigen processing and presentation (GO:0002577)6.19133292
5negative regulation of receptor-mediated endocytosis (GO:0048261)5.78612982
6fusion of sperm to egg plasma membrane (GO:0007342)5.46373005
7complement activation, alternative pathway (GO:0006957)4.65138568
8GPI anchor biosynthetic process (GO:0006506)4.44582111
9plasma membrane fusion (GO:0045026)4.22483556
10GPI anchor metabolic process (GO:0006505)4.09013918
11regulation of hydrogen peroxide metabolic process (GO:0010310)3.78066058
12brown fat cell differentiation (GO:0050873)3.68951624
13regulation of Cdc42 GTPase activity (GO:0043088)3.60546629
14response to misfolded protein (GO:0051788)3.44717373
15valine metabolic process (GO:0006573)3.38389082
16fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.35357375
17negative regulation of metanephros development (GO:0072217)3.32529645
18positive regulation of glomerulus development (GO:0090193)3.30928050
19macroautophagy (GO:0016236)3.25134816
20sulfur amino acid catabolic process (GO:0000098)3.22962867
21positive regulation of cellular response to oxidative stress (GO:1900409)3.22499120
22positive regulation of response to oxidative stress (GO:1902884)3.22499120
23eye photoreceptor cell differentiation (GO:0001754)3.19787063
24photoreceptor cell differentiation (GO:0046530)3.19787063
25respiratory burst (GO:0045730)3.18189022
26regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.08912224
27white fat cell differentiation (GO:0050872)2.95196051
28low-density lipoprotein particle clearance (GO:0034383)2.89340959
29cell differentiation involved in metanephros development (GO:0072202)2.87274085
30regulation of hydrogen peroxide-induced cell death (GO:1903205)2.86269204
31metanephric nephron tubule development (GO:0072234)2.83513706
32metanephric tubule development (GO:0072170)2.83513706
33axon ensheathment in central nervous system (GO:0032291)2.79187922
34central nervous system myelination (GO:0022010)2.79187922
35epithelial cell differentiation involved in kidney development (GO:0035850)2.77528903
36mesenchymal cell differentiation involved in renal system development (GO:2001012)2.77259518
37mesenchymal cell differentiation involved in kidney development (GO:0072161)2.77259518
38negative regulation of protein autophosphorylation (GO:0031953)2.77052618
39cellular anion homeostasis (GO:0030002)2.76131600
40L-serine transport (GO:0015825)2.75038781
41pyrimidine nucleobase catabolic process (GO:0006208)2.74260241
42triglyceride catabolic process (GO:0019433)2.73579259
43regulation of lipoprotein metabolic process (GO:0050746)2.73445522
44regulation of calcium ion-dependent exocytosis (GO:0017158)2.72875297
45glycolipid biosynthetic process (GO:0009247)2.72441758
46cellular sodium ion homeostasis (GO:0006883)2.70473446
47negative regulation of endocytosis (GO:0045806)2.65766957
48cellular response to epinephrine stimulus (GO:0071872)2.65384821
49linoleic acid metabolic process (GO:0043651)2.64944354
50L-amino acid import (GO:0043092)2.63496036
51metanephric nephron epithelium development (GO:0072243)2.58547771
52positive regulation of smooth muscle cell migration (GO:0014911)2.57926637
53negative regulation of reactive oxygen species metabolic process (GO:2000378)2.57407211
54cell differentiation involved in kidney development (GO:0061005)2.57148223
55glycerolipid catabolic process (GO:0046503)2.55603128
56mannose metabolic process (GO:0006013)2.48937354
57import into cell (GO:0098657)2.48486102
58nucleobase catabolic process (GO:0046113)2.47926549
59adaptation of signaling pathway (GO:0023058)2.45333348
60glycerophospholipid catabolic process (GO:0046475)2.44137276
61neutral lipid catabolic process (GO:0046461)2.44077697
62acylglycerol catabolic process (GO:0046464)2.44077697
63metanephric epithelium development (GO:0072207)2.43402021
64serine transport (GO:0032329)2.42416094
65response to nitrosative stress (GO:0051409)2.42400677
66nephron tubule development (GO:0072080)2.41409791
67negative regulation of lipase activity (GO:0060192)2.39690880
68positive regulation of sterol transport (GO:0032373)2.39217923
69positive regulation of cholesterol transport (GO:0032376)2.39217923
70* negative regulation of endopeptidase activity (GO:0010951)2.39020923
71polyol transport (GO:0015791)2.37870147
72regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.34191291
73alpha-linolenic acid metabolic process (GO:0036109)2.34081667
74amino acid import (GO:0043090)2.33368519
75trivalent inorganic anion homeostasis (GO:0072506)2.33142532
76phosphate ion homeostasis (GO:0055062)2.33142532
77cytolysis (GO:0019835)2.32872379
78positive regulation of digestive system process (GO:0060456)2.32826777
79* negative regulation of peptidase activity (GO:0010466)2.31828735
80regulation of feeding behavior (GO:0060259)2.30885718
81nerve growth factor signaling pathway (GO:0038180)2.30287293
82retina vasculature morphogenesis in camera-type eye (GO:0061299)2.30239590
83mesonephros development (GO:0001823)2.27184151
84cranial nerve structural organization (GO:0021604)2.26776310
85cyclooxygenase pathway (GO:0019371)2.26243367
86negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.25985517
87regulation of sequestering of triglyceride (GO:0010889)2.25641097
88long-chain fatty acid biosynthetic process (GO:0042759)2.24698560
89renal tubule development (GO:0061326)2.24469022
90negative regulation of systemic arterial blood pressure (GO:0003085)2.23904012
91response to epinephrine (GO:0071871)2.22278219
92regulation of complement activation (GO:0030449)2.20898815
93cellular response to monoamine stimulus (GO:0071868)2.19635527
94cellular response to catecholamine stimulus (GO:0071870)2.19635527
95positive regulation of metanephros development (GO:0072216)2.18180941
96regulation of antigen processing and presentation of peptide antigen (GO:0002583)14.0216842
97antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)13.9260949
98antigen processing and presentation of endogenous peptide antigen (GO:0002483)13.9260949
99antigen processing and presentation via MHC class Ib (GO:0002475)13.0607573
100antigen processing and presentation of endogenous antigen (GO:0019883)11.6257545

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human5.92544010
2IGF1R_20145208_ChIP-Seq_DFB_Human3.59996648
3AR_21572438_ChIP-Seq_LNCaP_Human2.86663835
4EZH2_22144423_ChIP-Seq_EOC_Human2.52981741
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.42452364
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.29901134
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.24621611
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23859995
9GBX2_23144817_ChIP-Seq_PC3_Human2.16348658
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.14150909
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.14150909
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.13596836
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.11675319
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.07684516
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.05333149
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.02608134
17TAF15_26573619_Chip-Seq_HEK293_Human2.01039692
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98475468
19ESR1_21235772_ChIP-Seq_MCF-7_Human1.93086617
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.90017348
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.89025874
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88724978
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.85450838
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82390971
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76433627
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.69202138
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.63477698
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.56779273
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55975338
30RNF2_27304074_Chip-Seq_NSC_Mouse1.51412242
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.50311144
32ZNF274_21170338_ChIP-Seq_K562_Hela1.50165925
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47094352
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44864118
35SMAD4_21799915_ChIP-Seq_A2780_Human1.41083829
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40757954
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.36130872
38EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.35259438
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33989997
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.33771610
41* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33099778
42VDR_24787735_ChIP-Seq_THP-1_Human1.31284417
43P300_19829295_ChIP-Seq_ESCs_Human1.28773669
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.27045922
45TP53_18474530_ChIP-ChIP_U2OS_Human1.26138623
46CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25255611
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.25184668
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24414320
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22726342
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21397959
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20903618
52ELK4_26923725_Chip-Seq_MESODERM_Mouse1.20072187
53REST_21632747_ChIP-Seq_MESCs_Mouse1.19564675
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19234090
55STAT1_17558387_ChIP-Seq_HELA_Human1.18903014
56AHR_22903824_ChIP-Seq_MCF-7_Human1.16021319
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.15886691
58DROSHA_22980978_ChIP-Seq_HELA_Human1.14921454
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.14215610
60KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13530789
61CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13124633
62VDR_22108803_ChIP-Seq_LS180_Human1.12868430
63RUNX2_22187159_ChIP-Seq_PCA_Human1.08251290
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08122199
65SMAD4_21741376_ChIP-Seq_HESCs_Human1.05481558
66WDR5_24793694_ChIP-Seq_LNCAP_Human1.03024840
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02860039
68KDM2B_26808549_Chip-Seq_REH_Human1.02725068
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01663426
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.00915386
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99408524
72AR_25329375_ChIP-Seq_VCAP_Human0.98731034
73HTT_18923047_ChIP-ChIP_STHdh_Human0.98205093
74POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97982516
75PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97834280
76* SMAD3_21741376_ChIP-Seq_EPCs_Human0.97151054
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96686382
78MYC_19915707_ChIP-ChIP_AK7_Human0.96473961
79TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95620093
80KLF4_18555785_Chip-Seq_ESCs_Mouse0.93101968
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93044488
82SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92064007
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92058615
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91269209
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90549346
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88198600
87* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87234116
88RING1B_27294783_Chip-Seq_ESCs_Mouse0.87216363
89NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86401224
90SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85847435
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85542716
92* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84930643
93SMAD3_21741376_ChIP-Seq_HESCs_Human0.84930432
94NANOG_18555785_Chip-Seq_ESCs_Mouse0.84927900
95TAL1_26923725_Chip-Seq_HPCs_Mouse0.84775737
96NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84763749
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83744437
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.83589621
99PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82890113
100ER_23166858_ChIP-Seq_MCF-7_Human0.81672010

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.51380114
2MP0005670_abnormal_white_adipose3.70110917
3MP0002876_abnormal_thyroid_physiology2.98898597
4MP0003690_abnormal_glial_cell2.72442146
5MP0001501_abnormal_sleep_pattern2.57777411
6MP0006292_abnormal_olfactory_placode2.53951423
7MP0001486_abnormal_startle_reflex2.16603763
8MP0003195_calcinosis2.07271719
9MP0005666_abnormal_adipose_tissue2.05193990
10MP0003950_abnormal_plasma_membrane1.85568447
11MP0005375_adipose_tissue_phenotype1.74753167
12MP0010386_abnormal_urinary_bladder1.72446411
13MP0002254_reproductive_system_inflammat1.69620570
14MP0008438_abnormal_cutaneous_collagen1.68582446
15MP0004185_abnormal_adipocyte_glucose1.66876636
16MP0008004_abnormal_stomach_pH1.65082485
17MP0000566_synostosis1.62038048
18MP0000920_abnormal_myelination1.59605144
19MP0003880_abnormal_central_pattern1.56126280
20MP0002272_abnormal_nervous_system1.51746253
21MP0003938_abnormal_ear_development1.49776470
22MP0005171_absent_coat_pigmentation1.49369955
23MP0004270_analgesia1.48200075
24MP0004130_abnormal_muscle_cell1.48048058
25MP0002735_abnormal_chemical_nociception1.47053414
26MP0004742_abnormal_vestibular_system1.45437542
27MP0003878_abnormal_ear_physiology1.41730185
28MP0005377_hearing/vestibular/ear_phenot1.41730185
29MP0004043_abnormal_pH_regulation1.41403547
30MP0002572_abnormal_emotion/affect_behav1.41174137
31MP0003635_abnormal_synaptic_transmissio1.36481394
32MP0002064_seizures1.36384942
33MP0009745_abnormal_behavioral_response1.35083179
34MP0002102_abnormal_ear_morphology1.34744562
35MP0002736_abnormal_nociception_after1.34336253
36MP0001485_abnormal_pinna_reflex1.33672874
37MP0002139_abnormal_hepatobiliary_system1.32421186
38MP0002638_abnormal_pupillary_reflex1.31555498
39MP0001968_abnormal_touch/_nociception1.27703303
40MP0002249_abnormal_larynx_morphology1.26453719
41MP0002837_dystrophic_cardiac_calcinosis1.24681105
42MP0005195_abnormal_posterior_eye1.22633946
43MP0000026_abnormal_inner_ear1.22383241
44MP0010329_abnormal_lipoprotein_level1.22244336
45MP0000003_abnormal_adipose_tissue1.20384031
46MP0004019_abnormal_vitamin_homeostasis1.19087178
47MP0004134_abnormal_chest_morphology1.17914897
48MP0003879_abnormal_hair_cell1.15878186
49MP0002063_abnormal_learning/memory/cond1.15787901
50MP0005551_abnormal_eye_electrophysiolog1.14237167
51MP0004859_abnormal_synaptic_plasticity1.13802556
52MP0004885_abnormal_endolymph1.13455216
53MP0002229_neurodegeneration1.12664740
54MP0008995_early_reproductive_senescence1.11446767
55MP0001970_abnormal_pain_threshold1.11385949
56MP0005646_abnormal_pituitary_gland1.11253334
57MP0005275_abnormal_skin_tensile1.11001069
58MP0002733_abnormal_thermal_nociception1.10215294
59MP0001963_abnormal_hearing_physiology1.09843980
60MP0005423_abnormal_somatic_nervous1.08936035
61MP0001440_abnormal_grooming_behavior1.08866148
62MP0004272_abnormal_basement_membrane1.08481199
63MP0003724_increased_susceptibility_to1.06568978
64MP0005334_abnormal_fat_pad1.06236887
65MP0002971_abnormal_brown_adipose1.05200253
66MP0001177_atelectasis1.04567181
67MP0002734_abnormal_mechanical_nocicepti1.04336894
68MP0000681_abnormal_thyroid_gland1.04004930
69MP0003634_abnormal_glial_cell1.03313088
70MP0002118_abnormal_lipid_homeostasis1.03068631
71MP0009115_abnormal_fat_cell1.02898537
72MP0003828_pulmonary_edema1.02875133
73MP0005645_abnormal_hypothalamus_physiol1.02793272
74MP0004858_abnormal_nervous_system1.01585412
75MP0005409_darkened_coat_color1.00515574
76MP0002557_abnormal_social/conspecific_i1.00322269
77MP0005164_abnormal_response_to0.99625109
78MP0005535_abnormal_body_temperature0.99335011
79MP0009046_muscle_twitch0.98920442
80MP0002067_abnormal_sensory_capabilities0.98496716
81MP0005248_abnormal_Harderian_gland0.97483477
82MP0009379_abnormal_foot_pigmentation0.96148714
83MP0009763_increased_sensitivity_to0.95290724
84MP0005253_abnormal_eye_physiology0.95128347
85MP0005595_abnormal_vascular_smooth0.94770106
86MP0002752_abnormal_somatic_nervous0.93005394
87MP0000778_abnormal_nervous_system0.91326059
88MP0001764_abnormal_homeostasis0.91034549
89MP0001765_abnormal_ion_homeostasis0.90986895
90MP0000230_abnormal_systemic_arterial0.89240271
91MP0005379_endocrine/exocrine_gland_phen0.87050333
92MP0002277_abnormal_respiratory_mucosa0.86755753
93MP0003959_abnormal_lean_body0.86294941
94MP0003075_altered_response_to0.86280860
95MP0002882_abnormal_neuron_morphology0.81062275
96MP0006276_abnormal_autonomic_nervous0.80536256
97MP0003186_abnormal_redox_activity0.79966875
98MP0001727_abnormal_embryo_implantation0.79466269
99MP0005410_abnormal_fertilization0.78431793
100MP0002295_abnormal_pulmonary_circulatio0.78364484

Predicted human phenotypes

RankGene SetZ-score
1Choroideremia (HP:0001139)8.92924100
2Abnormality of the fovea (HP:0000493)8.08475016
3Abnormal rod and cone electroretinograms (HP:0008323)7.98406799
4Bony spicule pigmentary retinopathy (HP:0007737)7.03762086
5Vacuolated lymphocytes (HP:0001922)5.77369422
6Complement deficiency (HP:0004431)5.46469388
7Recurrent gram-negative bacterial infections (HP:0005420)4.56182259
8Stridor (HP:0010307)4.32525144
9Neurofibrillary tangles (HP:0002185)4.31649074
10Hypopigmentation of the fundus (HP:0007894)4.15860086
11Abnormality of complement system (HP:0005339)3.90774277
12Action tremor (HP:0002345)3.76383318
13Clumsiness (HP:0002312)3.64399202
1411 pairs of ribs (HP:0000878)3.63066705
15Hyperphosphatemia (HP:0002905)3.53285818
16Nonprogressive disorder (HP:0003680)3.52364480
17Vascular calcification (HP:0004934)3.44811421
18Cerebral inclusion bodies (HP:0100314)3.39300482
19Diaphragmatic weakness (HP:0009113)3.34661677
20Intention tremor (HP:0002080)3.30749338
21Potter facies (HP:0002009)3.26426632
22Facial shape deformation (HP:0011334)3.26426632
23Facial diplegia (HP:0001349)3.13408204
24Cardiovascular calcification (HP:0011915)3.09723782
25Hand muscle atrophy (HP:0009130)3.09690485
26Hypophosphatemic rickets (HP:0004912)3.07863256
27Abnormality of macular pigmentation (HP:0008002)3.05644432
28Thyroid-stimulating hormone excess (HP:0002925)3.04629105
29Oligomenorrhea (HP:0000876)2.89506440
30Decreased central vision (HP:0007663)2.83081831
31Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.75342353
32Degeneration of the lateral corticospinal tracts (HP:0002314)2.75342353
33Hemiplegia (HP:0002301)2.65095441
34Osteomalacia (HP:0002749)2.62697160
35Infantile muscular hypotonia (HP:0008947)2.57573843
36Hyperglycinuria (HP:0003108)2.56938690
37Aplasia involving bones of the extremities (HP:0009825)2.55352683
38Aplasia involving bones of the upper limbs (HP:0009823)2.55352683
39Aplasia of the phalanges of the hand (HP:0009802)2.55352683
40Metaphyseal cupping (HP:0003021)2.54381143
41Ankle clonus (HP:0011448)2.53672524
42Dyschromatopsia (HP:0007641)2.49028152
43Dysostosis multiplex (HP:0000943)2.46481428
44Distal upper limb amyotrophy (HP:0007149)2.42795883
45Upper limb amyotrophy (HP:0009129)2.42795883
46Missing ribs (HP:0000921)2.39361703
47Duplicated collecting system (HP:0000081)2.32937987
48Pigmentary retinal degeneration (HP:0001146)2.29466045
49Supranuclear gaze palsy (HP:0000605)2.29370237
50Hyperglycinemia (HP:0002154)2.28228945
51Hypoventilation (HP:0002791)2.20412339
52Agitation (HP:0000713)2.19875672
53Abnormality of macrophages (HP:0004311)2.17722259
54Hypertriglyceridemia (HP:0002155)2.16151478
55Parakeratosis (HP:0001036)2.16068861
56Aplasia of the musculature (HP:0100854)2.15136418
57Abnormality of glycine metabolism (HP:0010895)2.14848794
58Abnormality of serine family amino acid metabolism (HP:0010894)2.14848794
59Focal motor seizures (HP:0011153)2.14049989
60Acanthosis nigricans (HP:0000956)2.04842281
61Polar cataract (HP:0010696)2.04173433
62Central scotoma (HP:0000603)2.01169250
63Abnormality of the renal collecting system (HP:0004742)1.99245252
64Tubulointerstitial fibrosis (HP:0005576)1.93920375
65Myocardial infarction (HP:0001658)1.93459577
66Systemic lupus erythematosus (HP:0002725)1.93361942
67Abnormality of molar morphology (HP:0011070)1.91747713
68Abnormality of molar (HP:0011077)1.91747713
69Abnormality of the calcaneus (HP:0008364)1.91622746
70Prolonged neonatal jaundice (HP:0006579)1.91272281
71Progressive inability to walk (HP:0002505)1.90714404
72Hypoplasia of the iris (HP:0007676)1.90498676
73Subcapsular cataract (HP:0000523)1.90183440
74Mutism (HP:0002300)1.89265110
75Hyperthyroidism (HP:0000836)1.88710277
76Myopathic facies (HP:0002058)1.88491840
77Restlessness (HP:0000711)1.85184748
78Nasolacrimal duct obstruction (HP:0000579)1.81941087
79Abnormality of the dental root (HP:0006486)1.76187459
80Taurodontia (HP:0000679)1.76187459
81Abnormality of permanent molar morphology (HP:0011071)1.76187459
82Congenital stationary night blindness (HP:0007642)1.76176585
83Epileptic encephalopathy (HP:0200134)1.75750526
84Long nose (HP:0003189)1.75454849
85Abnormality of the lumbar spine (HP:0100712)1.74976750
86Atelectasis (HP:0100750)1.70896415
87Abnormality of the middle phalanges of the toes (HP:0010183)1.63597233
88Bulbar palsy (HP:0001283)1.62290089
89Macular degeneration (HP:0000608)1.61444986
90Widely spaced teeth (HP:0000687)1.60682944
91Cone-rod dystrophy (HP:0000548)1.60008136
92Abnormality of the corticospinal tract (HP:0002492)1.59418679
93Abnormality of renal resorption (HP:0011038)1.59184390
94White forelock (HP:0002211)1.57780540
95Myokymia (HP:0002411)1.55210830
96Loss of speech (HP:0002371)1.54861536
97Abnormality of the dental pulp (HP:0006479)1.54380487
98Focal segmental glomerulosclerosis (HP:0000097)1.53989801
99Progressive visual loss (HP:0000529)1.53877835
100Thin ribs (HP:0000883)1.52844424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.34702908
2CDK193.29553797
3INSRR2.95347669
4TAOK32.77700494
5PRPF4B2.43117030
6WNK42.37849617
7MYLK2.31133163
8EPHB22.23098707
9SIK12.12857624
10MAP2K72.04386373
11RIPK42.02240756
12STK391.70744857
13IRAK21.69328000
14PKN11.63327374
15NTRK31.61103322
16SIK31.55900235
17WNK11.53189698
18LMTK21.51348957
19SIK21.49201769
20EPHB11.46504758
21BLK1.44150274
22BCR1.43370657
23TNIK1.40932887
24IRAK11.40373787
25BMPR1B1.37925042
26EPHA41.31001868
27MKNK21.25568671
28IRAK31.24776757
29OXSR11.23533921
30MST41.21910316
31MARK11.21564274
32PBK1.20100556
33GRK71.19229648
34PHKG11.16299619
35PHKG21.16299619
36MAP2K41.14616685
37MAP3K141.12444836
38BMX1.12019452
39MAP3K41.11525523
40MAPK131.06827714
41NTRK21.06563487
42BMPR21.02932409
43GRK51.02293827
44GRK10.99936861
45MST1R0.97820261
46FGR0.95124547
47DAPK20.93131877
48TIE10.91081457
49FER0.89215613
50LATS10.88632348
51PRKCG0.87056194
52NEK60.84775379
53PINK10.83398714
54AKT30.83097012
55DDR20.82303939
56PRKCE0.81954802
57ADRBK20.79927949
58PAK30.77607334
59YES10.76544884
60FRK0.76530906
61ERBB40.75275863
62STK160.75125419
63CDK50.72255929
64SGK10.71240246
65MAPK120.69037979
66CAMK1D0.68812199
67MAP3K120.67535333
68PRKCH0.66872268
69PTK2B0.66681354
70TNK20.66554501
71FYN0.66190212
72CAMK1G0.63605477
73MET0.63545030
74CAMK2A0.62134490
75FGFR20.60742888
76STK38L0.60430528
77CAMK2B0.59597472
78PRKCZ0.58106830
79SRC0.57914142
80SGK2230.57450150
81SGK4940.57450150
82INSR0.56702711
83PRKACA0.51390840
84MAP3K130.50237356
85ADRBK10.48226665
86EGFR0.47259135
87FES0.43626781
88MUSK0.43575115
89PRKG10.43440509
90PRKACG0.42854909
91IRAK40.42329308
92LATS20.39395123
93TGFBR20.38473715
94MAPK70.37366569
95MAP2K10.36958903
96DYRK20.35962978
97ERBB30.35389588
98PAK60.35143374
99CAMK2G0.34128309
100ERBB20.33830433

Predicted pathways (KEGG)

RankGene SetZ-score
1Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.68288553
2ABC transporters_Homo sapiens_hsa020102.81723227
3Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.55588379
4Other glycan degradation_Homo sapiens_hsa005112.44244496
5Sulfur metabolism_Homo sapiens_hsa009202.41920467
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.36705750
7PPAR signaling pathway_Homo sapiens_hsa033202.29566244
8Glycerolipid metabolism_Homo sapiens_hsa005611.99535234
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.94674028
10Fatty acid metabolism_Homo sapiens_hsa012121.89333681
11Salivary secretion_Homo sapiens_hsa049701.85360887
12Phototransduction_Homo sapiens_hsa047441.77590496
13Tyrosine metabolism_Homo sapiens_hsa003501.76311100
14Phenylalanine metabolism_Homo sapiens_hsa003601.70556082
15Vitamin B6 metabolism_Homo sapiens_hsa007501.65348582
16beta-Alanine metabolism_Homo sapiens_hsa004101.60281272
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.55145205
18Staphylococcus aureus infection_Homo sapiens_hsa051501.48776954
19Prion diseases_Homo sapiens_hsa050201.47988477
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46478206
21Fatty acid degradation_Homo sapiens_hsa000711.45949223
22Arachidonic acid metabolism_Homo sapiens_hsa005901.42251665
23Renin secretion_Homo sapiens_hsa049241.39303341
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38762706
25Fatty acid elongation_Homo sapiens_hsa000621.29859067
26Vitamin digestion and absorption_Homo sapiens_hsa049771.28604109
27Complement and coagulation cascades_Homo sapiens_hsa046101.28488383
28Collecting duct acid secretion_Homo sapiens_hsa049661.27262733
29Nicotine addiction_Homo sapiens_hsa050331.26456389
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25307485
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24504778
32African trypanosomiasis_Homo sapiens_hsa051431.24495270
33Lysosome_Homo sapiens_hsa041421.19744643
34Fatty acid biosynthesis_Homo sapiens_hsa000611.17695051
35Morphine addiction_Homo sapiens_hsa050321.17556741
36GABAergic synapse_Homo sapiens_hsa047271.16777656
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.10467439
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10043667
39Propanoate metabolism_Homo sapiens_hsa006401.04585917
40Chemical carcinogenesis_Homo sapiens_hsa052041.03154178
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03151801
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00131048
43Taste transduction_Homo sapiens_hsa047420.99830267
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99506122
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93673181
46Glutamatergic synapse_Homo sapiens_hsa047240.93274537
47Rheumatoid arthritis_Homo sapiens_hsa053230.92991613
48Nitrogen metabolism_Homo sapiens_hsa009100.92677212
49Serotonergic synapse_Homo sapiens_hsa047260.89321892
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88471470
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87948158
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.87171015
53Circadian entrainment_Homo sapiens_hsa047130.86512932
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85209833
55Calcium signaling pathway_Homo sapiens_hsa040200.85048410
56Peroxisome_Homo sapiens_hsa041460.83523560
57Sphingolipid metabolism_Homo sapiens_hsa006000.81862907
58Mineral absorption_Homo sapiens_hsa049780.81472317
59Autoimmune thyroid disease_Homo sapiens_hsa053200.79409409
60Arginine biosynthesis_Homo sapiens_hsa002200.78676579
61Regulation of autophagy_Homo sapiens_hsa041400.78583043
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.76761940
63Gastric acid secretion_Homo sapiens_hsa049710.74650348
64cAMP signaling pathway_Homo sapiens_hsa040240.74199316
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.72310867
66Thyroid hormone synthesis_Homo sapiens_hsa049180.71658283
67Glutathione metabolism_Homo sapiens_hsa004800.70890614
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.69302030
69Protein digestion and absorption_Homo sapiens_hsa049740.69247030
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67662737
71Synaptic vesicle cycle_Homo sapiens_hsa047210.63451209
72Graft-versus-host disease_Homo sapiens_hsa053320.63422295
73Axon guidance_Homo sapiens_hsa043600.63370249
74Fat digestion and absorption_Homo sapiens_hsa049750.62977572
75Ovarian steroidogenesis_Homo sapiens_hsa049130.62079142
76Vibrio cholerae infection_Homo sapiens_hsa051100.60668900
77Histidine metabolism_Homo sapiens_hsa003400.59392148
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59124278
79Phagosome_Homo sapiens_hsa041450.59006303
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57884482
81ECM-receptor interaction_Homo sapiens_hsa045120.56647375
82Butanoate metabolism_Homo sapiens_hsa006500.56444577
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52718389
84Long-term depression_Homo sapiens_hsa047300.50019908
85Tryptophan metabolism_Homo sapiens_hsa003800.47676237
86Cholinergic synapse_Homo sapiens_hsa047250.47368574
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45855114
88Arginine and proline metabolism_Homo sapiens_hsa003300.45609033
89Ether lipid metabolism_Homo sapiens_hsa005650.44122068
90Pertussis_Homo sapiens_hsa051330.41513362
91Linoleic acid metabolism_Homo sapiens_hsa005910.39209660
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39025240
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38780474
94Retinol metabolism_Homo sapiens_hsa008300.38077741
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.37674784
96Pancreatic secretion_Homo sapiens_hsa049720.37300942
97Insulin secretion_Homo sapiens_hsa049110.36237269
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34767725
99Olfactory transduction_Homo sapiens_hsa047400.32357786
100Dopaminergic synapse_Homo sapiens_hsa047280.31958809

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