WFDC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. The encoded protein contains four WFDC domains. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Alternatively spliced transcript variants have been observed but their full-length nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.20696893
2behavioral response to nicotine (GO:0035095)8.12129062
3pattern specification involved in kidney development (GO:0061004)8.06055444
4regulation of acrosome reaction (GO:0060046)7.32117404
5regulation of hydrogen peroxide metabolic process (GO:0010310)7.06355215
6regulation of glucocorticoid metabolic process (GO:0031943)6.74616491
7positive regulation of p38MAPK cascade (GO:1900745)6.05355924
8negative regulation of keratinocyte proliferation (GO:0010839)5.91416349
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.82429649
10positive regulation of odontogenesis (GO:0042482)5.76613802
11negative regulation of hormone biosynthetic process (GO:0032353)5.71533422
12negative regulation of hormone metabolic process (GO:0032351)5.71533422
13oligosaccharide biosynthetic process (GO:0009312)5.67310479
14pyrimidine-containing compound transmembrane transport (GO:0072531)5.41070896
15regulation of vascular endothelial growth factor signaling pathway (GO:1900746)5.10337014
16epithelial cilium movement (GO:0003351)5.03284919
17regulation of respiratory burst (GO:0060263)5.01029058
18platelet dense granule organization (GO:0060155)4.96682274
19cell proliferation in forebrain (GO:0021846)4.95868361
20axonemal dynein complex assembly (GO:0070286)4.74943660
21regulation of clathrin-mediated endocytosis (GO:2000369)4.68940237
22endocardial cushion morphogenesis (GO:0003203)4.63537038
23chondrocyte development (GO:0002063)4.61330466
24establishment of skin barrier (GO:0061436)4.59528383
25rRNA methylation (GO:0031167)4.54897370
26regulation of apoptotic process involved in morphogenesis (GO:1902337)4.52811154
27regulation of steroid hormone biosynthetic process (GO:0090030)4.52690465
28hair cell differentiation (GO:0035315)4.52031075
29cilium movement (GO:0003341)4.47232980
30positive regulation of cartilage development (GO:0061036)4.46919338
31regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.46080248
32positive regulation of chondrocyte differentiation (GO:0032332)4.44064911
33protein neddylation (GO:0045116)4.42828916
34regulation of p38MAPK cascade (GO:1900744)4.36721888
35regulation of water loss via skin (GO:0033561)4.35409113
36neural tube formation (GO:0001841)4.26612755
37keratinocyte development (GO:0003334)4.24503793
38segment specification (GO:0007379)4.23029618
39epithelial cell maturation (GO:0002070)4.20639430
40rRNA modification (GO:0000154)4.17343398
41ectoderm development (GO:0007398)4.16285626
42cilium or flagellum-dependent cell motility (GO:0001539)4.15150143
43ovulation cycle (GO:0042698)4.15025296
44proximal/distal pattern formation (GO:0009954)4.12356679
45transcytosis (GO:0045056)4.10635825
46regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.07339461
47hemidesmosome assembly (GO:0031581)4.01855080
48positive regulation of respiratory burst (GO:0060267)4.01220063
49atrioventricular valve morphogenesis (GO:0003181)4.00738931
50bundle of His cell to Purkinje myocyte communication (GO:0086069)3.95787955
51mammary gland epithelial cell differentiation (GO:0060644)3.91547927
52regulation of DNA endoreduplication (GO:0032875)3.88241329
53branching involved in prostate gland morphogenesis (GO:0060442)3.87425345
54neural crest cell development (GO:0014032)3.87037602
55mitochondrial respiratory chain complex I assembly (GO:0032981)3.85488161
56NADH dehydrogenase complex assembly (GO:0010257)3.85488161
57mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.85488161
58long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.83410954
59positive regulation of osteoblast proliferation (GO:0033690)3.82992379
60pericardium development (GO:0060039)3.79010827
61protein complex biogenesis (GO:0070271)3.75133298
62fatty-acyl-CoA biosynthetic process (GO:0046949)3.74971503
63regulation of cilium movement (GO:0003352)3.73328871
64long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.69586640
65regulation of sequestering of triglyceride (GO:0010889)3.67854864
66G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.66069105
67telencephalon development (GO:0021537)3.64533253
68pathway-restricted SMAD protein phosphorylation (GO:0060389)3.63840113
69fatty-acyl-CoA metabolic process (GO:0035337)3.59843659
70response to phenylpropanoid (GO:0080184)3.58573492
71cilium morphogenesis (GO:0060271)3.56955602
72mesenchyme morphogenesis (GO:0072132)3.54467543
73glomerular filtration (GO:0003094)3.54436056
74negative regulation of transcription regulatory region DNA binding (GO:2000678)3.53869837
75thioester biosynthetic process (GO:0035384)3.53338333
76acyl-CoA biosynthetic process (GO:0071616)3.53338333
77multicellular organismal water homeostasis (GO:0050891)3.49020390
78regulation of male gonad development (GO:2000018)3.46336925
79mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.38239501
80positive regulation of bone mineralization (GO:0030501)3.38192255
81phosphatidylinositol acyl-chain remodeling (GO:0036149)3.37029318
82mitochondrial respiratory chain complex assembly (GO:0033108)3.35796524
83primary amino compound metabolic process (GO:1901160)3.35013069
84skin morphogenesis (GO:0043589)3.33185355
85synaptic transmission, cholinergic (GO:0007271)3.29069607
86negative regulation of DNA-dependent DNA replication (GO:2000104)3.26068488
87multicellular organism reproduction (GO:0032504)3.25885788
88positive regulation of amino acid transport (GO:0051957)3.25033164
89negative regulation of execution phase of apoptosis (GO:1900118)3.24759412
90energy coupled proton transport, down electrochemical gradient (GO:0015985)3.24703245
91ATP synthesis coupled proton transport (GO:0015986)3.24703245
92N-acetylneuraminate metabolic process (GO:0006054)3.24065499
93glandular epithelial cell differentiation (GO:0002067)3.22307716
94water homeostasis (GO:0030104)3.22188213
95serotonin metabolic process (GO:0042428)3.21647791
96vitamin catabolic process (GO:0009111)3.20563042
97fat-soluble vitamin catabolic process (GO:0042363)3.20563042
98positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.20410901
99beta-amyloid metabolic process (GO:0050435)3.19829924
100pyrimidine nucleobase catabolic process (GO:0006208)3.18754996
101prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.18539842
102indolalkylamine metabolic process (GO:0006586)3.16598052
103positive regulation of biomineral tissue development (GO:0070169)3.14992602
104regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.14764170
105protein polyglutamylation (GO:0018095)3.14303810
106renal filtration (GO:0097205)3.14176949
107regulation of phospholipase A2 activity (GO:0032429)3.13732298
108RNA destabilization (GO:0050779)3.12404393
109lactation (GO:0007595)3.11505385
110positive regulation of astrocyte differentiation (GO:0048711)3.10728787
111axoneme assembly (GO:0035082)3.09990592
112regulation of dopamine secretion (GO:0014059)3.08725926
113UDP-N-acetylglucosamine metabolic process (GO:0006047)3.04715624
114regulation of vasculogenesis (GO:2001212)3.01532913
115mesenchymal cell development (GO:0014031)3.00827750
116protein-cofactor linkage (GO:0018065)3.00164371
117intestinal epithelial cell development (GO:0060576)2.99521435
118sphingosine metabolic process (GO:0006670)2.98629783
119negative regulation of lipase activity (GO:0060192)2.98528942
120cellular response to ATP (GO:0071318)2.96873428
121heart valve morphogenesis (GO:0003179)2.96117349
122organic cation transport (GO:0015695)2.95767354
123membrane repolarization during action potential (GO:0086011)2.94510946
124artery development (GO:0060840)2.93820214
125cilium organization (GO:0044782)2.93597486
126negative regulation of transcription by competitive promoter binding (GO:0010944)2.92128588
127positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.89408152
128prostate gland epithelium morphogenesis (GO:0060740)2.89374697
129epidermal cell differentiation (GO:0009913)2.89090594
130cilium assembly (GO:0042384)2.88498606
131regulation of calcium ion-dependent exocytosis (GO:0017158)2.87696107
132cell differentiation in spinal cord (GO:0021515)2.86079515
133secretion by tissue (GO:0032941)2.86061089
134icosanoid secretion (GO:0032309)2.85273916
135arachidonic acid secretion (GO:0050482)2.85273916
136sequestering of actin monomers (GO:0042989)2.84859992
137nucleotide transmembrane transport (GO:1901679)2.84113649
138linoleic acid metabolic process (GO:0043651)2.83439889
139sperm motility (GO:0030317)2.82790417
140cell differentiation involved in metanephros development (GO:0072202)2.81304372
141spinal cord motor neuron differentiation (GO:0021522)2.80473012
142negative regulation of alcohol biosynthetic process (GO:1902931)2.78749416
143keratinocyte differentiation (GO:0030216)2.78396416
144regulation of keratinocyte proliferation (GO:0010837)2.77845460
145regulation of hormone biosynthetic process (GO:0046885)2.77815960
146negative regulation of response to food (GO:0032096)2.77143077
147negative regulation of appetite (GO:0032099)2.77143077
148regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.76842992
149sphingoid metabolic process (GO:0046519)2.76626973
150anterior/posterior axis specification, embryo (GO:0008595)2.75222210
151nonmotile primary cilium assembly (GO:0035058)2.75192273
152membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.74721852
153response to pheromone (GO:0019236)2.73525882
154epidermis development (GO:0008544)2.73443320
155zinc ion transport (GO:0006829)2.70074696
156cerebral cortex radially oriented cell migration (GO:0021799)2.66831389
157regulation of feeding behavior (GO:0060259)2.66182625
158indole-containing compound metabolic process (GO:0042430)2.64008586
159fusion of sperm to egg plasma membrane (GO:0007342)2.63166960
160fucose catabolic process (GO:0019317)2.62362328
161L-fucose metabolic process (GO:0042354)2.62362328
162L-fucose catabolic process (GO:0042355)2.62362328
163negative regulation of mast cell activation (GO:0033004)2.61266047
164meiotic chromosome segregation (GO:0045132)2.60976503
165acrosome reaction (GO:0007340)2.60759611
166nucleobase catabolic process (GO:0046113)2.60501356
167spinal cord association neuron differentiation (GO:0021527)2.59503484
168centriole replication (GO:0007099)2.58361861
169phosphatidylcholine acyl-chain remodeling (GO:0036151)2.56496312
170phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.55924402
171regulation of microtubule-based movement (GO:0060632)2.55155404
172nephron epithelium morphogenesis (GO:0072088)2.54252100
173nephron tubule morphogenesis (GO:0072078)2.54252100
174DNA methylation involved in gamete generation (GO:0043046)2.53905022
175regulation of pigment cell differentiation (GO:0050932)2.53633322
176phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.53197094
177forebrain neuron differentiation (GO:0021879)2.48795188
178positive regulation of organic acid transport (GO:0032892)2.47928568
179kynurenine metabolic process (GO:0070189)2.47766235
180phenylpropanoid metabolic process (GO:0009698)2.46428672
181tachykinin receptor signaling pathway (GO:0007217)2.45777762
182protein localization to cilium (GO:0061512)2.45095779
183response to gravity (GO:0009629)2.44781482
184C4-dicarboxylate transport (GO:0015740)2.44746482
185positive regulation of meiosis (GO:0045836)2.44443507
186detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.44434523
187preassembly of GPI anchor in ER membrane (GO:0016254)2.44269108
188tyrosine metabolic process (GO:0006570)2.43805710
189retinal cone cell development (GO:0046549)2.43487519
190indole-containing compound catabolic process (GO:0042436)2.42820994
191indolalkylamine catabolic process (GO:0046218)2.42820994
192tryptophan catabolic process (GO:0006569)2.42820994
193regulation of glucokinase activity (GO:0033131)2.41934069
194regulation of hexokinase activity (GO:1903299)2.41934069
195protein K6-linked ubiquitination (GO:0085020)2.41329285
196negative regulation of telomere maintenance (GO:0032205)2.40736309
197response to xenobiotic stimulus (GO:0009410)2.38748905
198glycerophospholipid catabolic process (GO:0046475)2.37802377
199phosphatidylserine acyl-chain remodeling (GO:0036150)2.37192552

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.79549252
2EZH2_22144423_ChIP-Seq_EOC_Human4.91024900
3ESR1_21235772_ChIP-Seq_MCF-7_Human4.73735427
4* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse3.87171575
5ZNF274_21170338_ChIP-Seq_K562_Hela3.40609009
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.38495710
7ESR2_21235772_ChIP-Seq_MCF-7_Human3.29502868
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.94494346
9VDR_22108803_ChIP-Seq_LS180_Human2.74440272
10* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.72969070
11GBX2_23144817_ChIP-Seq_PC3_Human2.67368234
12AR_21572438_ChIP-Seq_LNCaP_Human2.59281344
13ZNF217_24962896_ChIP-Seq_MCF-7_Human2.58108822
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.25293471
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.22505866
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19069101
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.93243515
18SOX2_20726797_ChIP-Seq_SW620_Human1.91848696
19* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88815249
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83543670
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.80415141
22REST_21632747_ChIP-Seq_MESCs_Mouse1.79516544
23ER_23166858_ChIP-Seq_MCF-7_Human1.78671388
24P300_19829295_ChIP-Seq_ESCs_Human1.76687360
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73488297
26FUS_26573619_Chip-Seq_HEK293_Human1.71981418
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.71636472
28TP53_18474530_ChIP-ChIP_U2OS_Human1.67555269
29AHR_22903824_ChIP-Seq_MCF-7_Human1.62398877
30ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.59508747
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59434620
32FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.58205865
33SOX2_19829295_ChIP-Seq_ESCs_Human1.56281474
34NANOG_19829295_ChIP-Seq_ESCs_Human1.56281474
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54479453
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.53182230
37EWS_26573619_Chip-Seq_HEK293_Human1.52012892
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51684721
39ETV2_25802403_ChIP-Seq_MESCs_Mouse1.51651313
40TP63_23658742_ChIP-Seq_EP156T_Human1.50197639
41TAF15_26573619_Chip-Seq_HEK293_Human1.47371744
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47024722
43GATA3_21878914_ChIP-Seq_MCF-7_Human1.46952117
44P63_26484246_Chip-Seq_KERATINOCYTES_Human1.45054722
45KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.44651475
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44255018
47FOXM1_26456572_ChIP-Seq_MCF-7_Human1.44055187
48GATA4_25053715_ChIP-Seq_YYC3_Human1.43971440
49CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42986741
50* RUNX1_27514584_Chip-Seq_MCF-7_Human1.39684785
51TP53_22573176_ChIP-Seq_HFKS_Human1.38536530
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37051811
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36085699
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36085699
55SMAD4_21799915_ChIP-Seq_A2780_Human1.35733087
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35254240
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.35103296
58EP300_21415370_ChIP-Seq_HL-1_Mouse1.34201066
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33996543
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33835075
61SMAD3_21741376_ChIP-Seq_HESCs_Human1.32811850
62* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32452863
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31453716
64* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31364325
65STAT3_23295773_ChIP-Seq_U87_Human1.30314568
66KLF5_25053715_ChIP-Seq_YYC3_Human1.29923037
67SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29568286
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27692106
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27692106
70FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.26494644
71RXR_22108803_ChIP-Seq_LS180_Human1.26352201
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23206943
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22928118
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22651908
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21945081
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.21938811
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21854361
78IRF1_19129219_ChIP-ChIP_H3396_Human1.20764324
79NCOR_22424771_ChIP-Seq_293T_Human1.20323799
80CBP_20019798_ChIP-Seq_JUKART_Human1.20224163
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20224163
82ZNF263_19887448_ChIP-Seq_K562_Human1.18885327
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18799681
84FOXA1_25329375_ChIP-Seq_VCAP_Human1.18349291
85FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18349291
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18187191
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.17948612
88TCF4_23295773_ChIP-Seq_U87_Human1.17440807
89BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17077284
90GATA3_24758297_ChIP-Seq_MCF-7_Human1.16649153
91AR_20517297_ChIP-Seq_VCAP_Human1.15269397
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.14571144
93SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14548417
94RNF2_27304074_Chip-Seq_ESCs_Mouse1.14425764
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13882078
96MYC_19829295_ChIP-Seq_ESCs_Human1.13551356
97PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13378552
98CBX2_27304074_Chip-Seq_ESCs_Mouse1.13122352
99IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12381926
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.12259505
101ESR1_20079471_ChIP-ChIP_T-47D_Human1.11653616
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11413748
103IGF1R_20145208_ChIP-Seq_DFB_Human1.11412554
104MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11285486
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11063249
106EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10745390
107RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10513532
108AR_25329375_ChIP-Seq_VCAP_Human1.08703932
109RNF2_27304074_Chip-Seq_NSC_Mouse1.08510999
110LXR_22158963_ChIP-Seq_LIVER_Mouse1.08020985
111SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07430500
112ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.06566549
113JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06278377
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05434565
115* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05398185
116NANOG_20526341_ChIP-Seq_ESCs_Human1.05277573
117PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05256920
118AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05116431
119ERA_21632823_ChIP-Seq_H3396_Human1.05006484
120CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04681726
121NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04617630
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04511386
123STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03911633
124* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03631566
125REST_18959480_ChIP-ChIP_MESCs_Mouse1.03551474
126JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03085491
127FOXH1_21741376_ChIP-Seq_EPCs_Human1.02266611
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02041631
129GATA1_26923725_Chip-Seq_HPCs_Mouse1.01881277
130OCT4_20526341_ChIP-Seq_ESCs_Human1.00076381
131NANOG_18555785_Chip-Seq_ESCs_Mouse0.99415388
132TCF4_22108803_ChIP-Seq_LS180_Human0.99010842
133STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98716339
134TBX20_22328084_ChIP-Seq_HEART_Mouse0.98597213
135TBX20_22080862_ChIP-Seq_HEART_Mouse0.98597213
136* CJUN_26792858_Chip-Seq_BT549_Human0.98408922
137SMAD3_21741376_ChIP-Seq_EPCs_Human0.97904980
138ERG_21242973_ChIP-ChIP_JURKAT_Human0.97863653
139RUNX2_22187159_ChIP-Seq_PCA_Human0.97175043
140LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96986942
141FOXA1_25552417_ChIP-Seq_VCAP_Human0.96961436
142POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96718620
143PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95504815
144STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94085548
145BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.93887557
146EED_16625203_ChIP-ChIP_MESCs_Mouse0.92101270
147MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91598940
148EZH2_27294783_Chip-Seq_ESCs_Mouse0.90983658
149BCAT_22108803_ChIP-Seq_LS180_Human0.90133961
150RXR_22158963_ChIP-Seq_LIVER_Mouse0.89713418
151RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88897552
152CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88548818
153ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87700206
154CLOCK_20551151_ChIP-Seq_293T_Human0.87106555
155KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86566424
156CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86208233
157TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85864342
158TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85860129
159TCF4_18268006_ChIP-ChIP_LS174T_Human0.84962531
160SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.84432775
161FOXA1_21572438_ChIP-Seq_LNCaP_Human0.83972388
162STAT1_17558387_ChIP-Seq_HELA_Human0.82630211
163PKCTHETA_26484144_Chip-Seq_BREAST_Human0.80241365
164EZH2_27304074_Chip-Seq_ESCs_Mouse0.80185766
165CDX2_22108803_ChIP-Seq_LS180_Human0.80105819
166GATA6_25053715_ChIP-Seq_YYC3_Human0.79344387
167ISL1_27105846_Chip-Seq_CPCs_Mouse0.79228401

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001881_abnormal_mammary_gland5.36307471
2MP0005275_abnormal_skin_tensile4.43266123
3MP0002796_impaired_skin_barrier4.00156630
4MP0000579_abnormal_nail_morphology3.73351727
5MP0010678_abnormal_skin_adnexa3.55202007
6MP0002098_abnormal_vibrissa_morphology3.25248568
7MP0002837_dystrophic_cardiac_calcinosis2.98025635
8MP0001873_stomach_inflammation2.39251118
9MP0002163_abnormal_gland_morphology2.33936319
10MP0008875_abnormal_xenobiotic_pharmacok2.24961529
11MP0003136_yellow_coat_color2.22443909
12MP0005501_abnormal_skin_physiology2.22108589
13MP0005551_abnormal_eye_electrophysiolog2.21425104
14MP0000377_abnormal_hair_follicle2.18607177
15MP0004019_abnormal_vitamin_homeostasis2.13006308
16MP0000627_abnormal_mammary_gland2.12760566
17MP0010234_abnormal_vibrissa_follicle12.3823725
18MP0001968_abnormal_touch/_nociception1.99952700
19MP0006276_abnormal_autonomic_nervous1.97473935
20MP0004142_abnormal_muscle_tone1.93328073
21MP0005377_hearing/vestibular/ear_phenot1.90011133
22MP0003878_abnormal_ear_physiology1.90011133
23MP0004264_abnormal_extraembryonic_tissu1.89195170
24MP0002254_reproductive_system_inflammat1.84439917
25MP0003300_gastrointestinal_ulcer1.81387831
26MP0001986_abnormal_taste_sensitivity1.80759062
27MP0002733_abnormal_thermal_nociception1.79103709
28MP0001346_abnormal_lacrimal_gland1.78205197
29MP0005451_abnormal_body_composition1.74867417
30MP0002160_abnormal_reproductive_system1.74716809
31MP0001485_abnormal_pinna_reflex1.74165271
32MP0009046_muscle_twitch1.73907409
33MP0003195_calcinosis1.72108391
34MP0003011_delayed_dark_adaptation1.71565124
35MP0010386_abnormal_urinary_bladder1.70124753
36MP0002009_preneoplasia1.68276803
37MP0000372_irregular_coat_pigmentation1.67991498
38MP0002938_white_spotting1.64735055
39MP0001919_abnormal_reproductive_system1.62941516
40MP0005084_abnormal_gallbladder_morpholo1.62376432
41MP0001970_abnormal_pain_threshold1.60075942
42MP0009745_abnormal_behavioral_response1.59887221
43MP0005646_abnormal_pituitary_gland1.59021660
44MP0008872_abnormal_physiological_respon1.57376211
45MP0005379_endocrine/exocrine_gland_phen1.57320223
46MP0002736_abnormal_nociception_after1.55779223
47MP0002735_abnormal_chemical_nociception1.51412509
48MP0001216_abnormal_epidermal_layer1.51144661
49MP0004185_abnormal_adipocyte_glucose1.49587653
50MP0000566_synostosis1.48918405
51MP0000026_abnormal_inner_ear1.46678602
52MP0002572_abnormal_emotion/affect_behav1.46406277
53MP0000778_abnormal_nervous_system1.45272215
54MP0002272_abnormal_nervous_system1.45262238
55MP0002751_abnormal_autonomic_nervous1.42331313
56MP0002928_abnormal_bile_duct1.41073852
57MP0002557_abnormal_social/conspecific_i1.39108747
58MP0003941_abnormal_skin_development1.38484023
59MP0002734_abnormal_mechanical_nocicepti1.37808532
60MP0008775_abnormal_heart_ventricle1.37180172
61MP0004134_abnormal_chest_morphology1.37129639
62MP0005253_abnormal_eye_physiology1.36988224
63MP0006292_abnormal_olfactory_placode1.34182904
64MP0010030_abnormal_orbit_morphology1.33246586
65MP0000631_abnormal_neuroendocrine_gland1.32840075
66MP0003890_abnormal_embryonic-extraembry1.31042986
67MP0003646_muscle_fatigue1.29767345
68MP0009384_cardiac_valve_regurgitation1.29696839
69MP0005310_abnormal_salivary_gland1.28870833
70MP0009780_abnormal_chondrocyte_physiolo1.24572185
71MP0003718_maternal_effect1.24398034
72MP0001440_abnormal_grooming_behavior1.24204898
73MP0003880_abnormal_central_pattern1.23840376
74MP0002060_abnormal_skin_morphology1.17401964
75MP0003123_paternal_imprinting1.16427749
76MP0005647_abnormal_sex_gland1.15431867
77MP0005171_absent_coat_pigmentation1.14619664
78MP0003566_abnormal_cell_adhesion1.14488337
79MP0002249_abnormal_larynx_morphology1.14058002
80MP0001905_abnormal_dopamine_level1.14044169
81MP0000613_abnormal_salivary_gland1.11410187
82MP0005187_abnormal_penis_morphology1.10808481
83MP0008995_early_reproductive_senescence1.10805524
84MP0010771_integument_phenotype1.10279213
85MP0004947_skin_inflammation1.08356429
86MP0002067_abnormal_sensory_capabilities1.07650642
87MP0004043_abnormal_pH_regulation1.07600352
88MP0000383_abnormal_hair_follicle1.07086818
89MP0003698_abnormal_male_reproductive1.06827623
90MP0000647_abnormal_sebaceous_gland1.04985458
91MP0004133_heterotaxia1.04396920
92MP0001293_anophthalmia1.03629929
93MP0003879_abnormal_hair_cell1.03364542
94MP0003453_abnormal_keratinocyte_physiol1.01907727
95MP0002638_abnormal_pupillary_reflex1.01361256
96MP0005645_abnormal_hypothalamus_physiol1.00401312
97MP0009764_decreased_sensitivity_to0.99601218
98MP0001666_abnormal_nutrient_absorption0.98727051
99MP0005195_abnormal_posterior_eye0.97887200
100MP0009697_abnormal_copulation0.97749592
101MP0000762_abnormal_tongue_morphology0.97091803
102MP0009250_abnormal_appendicular_skeleto0.95808158
103MP0002752_abnormal_somatic_nervous0.95501606
104MP0000230_abnormal_systemic_arterial0.95264784
105MP0002063_abnormal_learning/memory/cond0.94381892
106MP0001486_abnormal_startle_reflex0.94105040
107MP0004742_abnormal_vestibular_system0.92515730
108MP0005410_abnormal_fertilization0.92413971
109MP0008004_abnormal_stomach_pH0.92262888
110MP0002210_abnormal_sex_determination0.91832283
111MP0008877_abnormal_DNA_methylation0.90640040
112MP0003950_abnormal_plasma_membrane0.90348815
113MP0000955_abnormal_spinal_cord0.90182684
114MP0000163_abnormal_cartilage_morphology0.89485542
115MP0006054_spinal_hemorrhage0.89276554
116MP0001765_abnormal_ion_homeostasis0.88558534
117MP0002822_catalepsy0.88351493
118MP0002234_abnormal_pharynx_morphology0.87932920
119MP0003635_abnormal_synaptic_transmissio0.87200723
120MP0002064_seizures0.87007246
121MP0005360_urolithiasis0.86679312
122MP0001663_abnormal_digestive_system0.86141195
123MP0000049_abnormal_middle_ear0.84894654
124MP0002282_abnormal_trachea_morphology0.84856672
125MP0009379_abnormal_foot_pigmentation0.84479975
126MP0005464_abnormal_platelet_physiology0.84367412
127MP0005666_abnormal_adipose_tissue0.83880774
128MP0004484_altered_response_of0.83724318
129MP0003936_abnormal_reproductive_system0.82901294
130MP0003787_abnormal_imprinting0.82746790
131MP0002166_altered_tumor_susceptibility0.81635310
132MP0002882_abnormal_neuron_morphology0.81363226
133MP0002184_abnormal_innervation0.81192340
134MP0003121_genomic_imprinting0.81027815
135MP0005623_abnormal_meninges_morphology0.80673061
136MP0005389_reproductive_system_phenotype0.78452141
137MP0001849_ear_inflammation0.77814158
138MP0000534_abnormal_ureter_morphology0.76617991
139MP0003315_abnormal_perineum_morphology0.75804543
140MP0001529_abnormal_vocalization0.75369155
141MP0001984_abnormal_olfaction0.75001766
142MP0004215_abnormal_myocardial_fiber0.74522534
143MP0002909_abnormal_adrenal_gland0.74508767
144MP0005365_abnormal_bile_salt0.74478413
145MP0002229_neurodegeneration0.74334990
146MP0004381_abnormal_hair_follicle0.73522350
147MP0004085_abnormal_heartbeat0.73415643
148MP0000427_abnormal_hair_cycle0.72251385
149MP0004272_abnormal_basement_membrane0.70384941
150MP0002115_abnormal_skeleton_extremities0.68132371
151MP0005085_abnormal_gallbladder_physiolo0.67662393
152MP0003755_abnormal_palate_morphology0.67139932
153MP0000367_abnormal_coat/_hair0.65777613
154MP0005083_abnormal_biliary_tract0.64404219
155MP0005395_other_phenotype0.63697550
156MP0002006_tumorigenesis0.63263477
157MP0004130_abnormal_muscle_cell0.61944672
158MP0002896_abnormal_bone_mineralization0.61663859
159MP0001348_abnormal_lacrimal_gland0.61026288
160MP0001191_abnormal_skin_condition0.60151151
161MP0005508_abnormal_skeleton_morphology0.59863761
162MP0006072_abnormal_retinal_apoptosis0.59860150
163MP0002111_abnormal_tail_morphology0.59793032
164MP0005076_abnormal_cell_differentiation0.59675210
165MP0003937_abnormal_limbs/digits/tail_de0.59228607
166MP0003705_abnormal_hypodermis_morpholog0.58054945
167MP0009931_abnormal_skin_appearance0.55510653
168MP0001851_eye_inflammation0.55462341
169MP0000858_altered_metastatic_potential0.53334099
170MP0002109_abnormal_limb_morphology0.51160889
171MP0005636_abnormal_mineral_homeostasis0.50137530
172MP0002653_abnormal_ependyma_morphology0.49980895
173MP0003699_abnormal_female_reproductive0.49595389
174MP0000013_abnormal_adipose_tissue0.48699428
175MP0004147_increased_porphyrin_level0.48400792
176MP0005375_adipose_tissue_phenotype0.47719713
177MP0003045_fibrosis0.47433279
178MP0001340_abnormal_eyelid_morphology0.46547980
179MP0000639_abnormal_adrenal_gland0.43184231
180MP0001756_abnormal_urination0.43072300
181MP0003385_abnormal_body_wall0.42421785
182MP0003303_peritoneal_inflammation0.42254437
183MP0001664_abnormal_digestion0.42105893
184MP0004885_abnormal_endolymph0.41416218
185MP0003935_abnormal_craniofacial_develop0.41335006
186MP0005408_hypopigmentation0.40125649

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.26776494
2Congenital nonbullous ichthyosiform erythroderma (HP:0007479)8.39870849
3Congenital ichthyosiform erythroderma (HP:0007431)7.00861547
4Abnormality of the phalanges of the 2nd finger (HP:0009541)5.56851010
5Dynein arm defect of respiratory motile cilia (HP:0012255)5.39869974
6Absent/shortened dynein arms (HP:0200106)5.39869974
7Onycholysis (HP:0001806)5.36083828
8Erythroderma (HP:0001019)5.29657368
9Abnormality of the 2nd finger (HP:0004100)5.23844662
10Abnormal ciliary motility (HP:0012262)5.16146877
11Abnormal respiratory motile cilium morphology (HP:0005938)5.08778052
12Abnormal respiratory epithelium morphology (HP:0012253)5.08778052
13Abnormality of the middle phalanx of the 5th finger (HP:0004219)4.80768594
14Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)4.70150125
15Molar tooth sign on MRI (HP:0002419)4.70089481
16Abnormality of midbrain morphology (HP:0002418)4.70089481
17Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)4.57616827
18Pancreatic cysts (HP:0001737)4.50626525
19Abnormality of the middle phalanges of the toes (HP:0010183)4.50332809
20Abnormality of the phalanges of the 5th finger (HP:0004213)4.40181213
21Chronic hepatic failure (HP:0100626)4.38820770
22Abnormality of small intestinal villus morphology (HP:0011472)4.22927372
23Villous atrophy (HP:0011473)4.22927372
24Aplasia involving bones of the upper limbs (HP:0009823)4.22406517
25Aplasia of the phalanges of the hand (HP:0009802)4.22406517
26Aplasia involving bones of the extremities (HP:0009825)4.22406517
27Abnormality of macular pigmentation (HP:0008002)4.17573054
28True hermaphroditism (HP:0010459)4.16588388
29Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)4.12194196
30Pancreatic fibrosis (HP:0100732)4.09295267
31Nephronophthisis (HP:0000090)3.92474554
32Right ventricular cardiomyopathy (HP:0011663)3.67944720
33Short hallux (HP:0010109)3.60534129
34Brittle hair (HP:0002299)3.39933155
35Abnormality of the proximal phalanges of the hand (HP:0009834)3.36287227
36Aplasia/Hypoplasia of the hallux (HP:0008362)3.35286355
37Sparse scalp hair (HP:0002209)3.33710070
38Fibular aplasia (HP:0002990)3.27532542
39Fragile nails (HP:0001808)3.26308836
40Aplasia/Hypoplasia of the sacrum (HP:0008517)3.23002922
41Concave nail (HP:0001598)3.18943008
42Cystic liver disease (HP:0006706)3.18440238
43Abnormality of the renal medulla (HP:0100957)3.14886798
44Acanthosis nigricans (HP:0000956)3.08902669
45Rhinitis (HP:0012384)2.97427346
46Sclerocornea (HP:0000647)2.93274134
47Hypotrichosis (HP:0001006)2.92161169
48Congenital stationary night blindness (HP:0007642)2.91559895
49Tubular atrophy (HP:0000092)2.90864257
50Hypoplasia of the uterus (HP:0000013)2.85002095
51Absent rod-and cone-mediated responses on ERG (HP:0007688)2.84079527
52Abnormality of the axillary hair (HP:0100134)2.82458793
53Abnormality of secondary sexual hair (HP:0009888)2.82458793
54Adrenal hypoplasia (HP:0000835)2.81742474
55Decreased central vision (HP:0007663)2.78172926
56Woolly hair (HP:0002224)2.76705014
57Symphalangism affecting the phalanges of the hand (HP:0009773)2.74814470
58Abnormal pancreas size (HP:0012094)2.73272061
59Thyroid-stimulating hormone excess (HP:0002925)2.73218740
60Bile duct proliferation (HP:0001408)2.71144899
61Abnormal biliary tract physiology (HP:0012439)2.71144899
62Chronic sinusitis (HP:0011109)2.70047660
633-Methylglutaconic aciduria (HP:0003535)2.69369024
64Medial flaring of the eyebrow (HP:0010747)2.65101747
65Type II lissencephaly (HP:0007260)2.64426063
662-3 toe syndactyly (HP:0004691)2.63661581
67Occipital encephalocele (HP:0002085)2.63072508
68Congenital sensorineural hearing impairment (HP:0008527)2.62691910
69Hypergammaglobulinemia (HP:0010702)2.62105595
70Lip pit (HP:0100267)2.57924174
71Amelogenesis imperfecta (HP:0000705)2.55969389
72Aplasia/hypoplasia of the uterus (HP:0008684)2.54091452
73Abnormal rod and cone electroretinograms (HP:0008323)2.47295109
74Abnormality of the renal cortex (HP:0011035)2.45993074
75Submucous cleft hard palate (HP:0000176)2.45303557
76Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.44557964
77Inability to walk (HP:0002540)2.42920646
78Ectropion (HP:0000656)2.41785452
79Curly hair (HP:0002212)2.41595507
80Aplasia/Hypoplasia of the fibula (HP:0006492)2.37964420
81Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.36350643
82Anencephaly (HP:0002323)2.34630832
83Steatorrhea (HP:0002570)2.34540250
84Abnormality of cochlea (HP:0000375)2.34492460
85Abnormal drinking behavior (HP:0030082)2.32643914
86Polydipsia (HP:0001959)2.32643914
87Acute necrotizing encephalopathy (HP:0006965)2.31769724
88Exocrine pancreatic insufficiency (HP:0001738)2.31486937
89Delayed CNS myelination (HP:0002188)2.30564235
90Supernumerary spleens (HP:0009799)2.29370455
91Male pseudohermaphroditism (HP:0000037)2.28221631
92Decreased circulating renin level (HP:0003351)2.27379858
93Chronic otitis media (HP:0000389)2.25008465
94Renal Fanconi syndrome (HP:0001994)2.24778908
95Congenital hepatic fibrosis (HP:0002612)2.22926991
96Aplasia/Hypoplasia of the tibia (HP:0005772)2.22695025
97Lissencephaly (HP:0001339)2.22542656
98Abnormality of the middle phalanges of the hand (HP:0009833)2.20528180
99Thickened helices (HP:0000391)2.20214497
100Fat malabsorption (HP:0002630)2.17624867
101Furrowed tongue (HP:0000221)2.17222813
102Clumsiness (HP:0002312)2.15840992
103Abnormality of purine metabolism (HP:0004352)2.15694992
104Abnormal sex determination (HP:0012244)2.15534562
105Sex reversal (HP:0012245)2.15534562
106Dehydration (HP:0001944)2.15512174
107Hyperventilation (HP:0002883)2.14991776
108Hypoplasia of the ulna (HP:0003022)2.14519226
109Anhidrosis (HP:0000970)2.13644825
110Down-sloping shoulders (HP:0200021)2.13431031
111Abnormal mitochondria in muscle tissue (HP:0008316)2.11667423
112Optic disc pallor (HP:0000543)2.11411475
113Mitochondrial inheritance (HP:0001427)2.10735515
114Aplasia/Hypoplasia of the tongue (HP:0010295)2.10110382
115Bronchiectasis (HP:0002110)2.08715236
116Nephrogenic diabetes insipidus (HP:0009806)2.08665264
117Acute encephalopathy (HP:0006846)2.08546109
118Anophthalmia (HP:0000528)2.07690965
119Natal tooth (HP:0000695)2.06772113
120Gait imbalance (HP:0002141)2.06593916
121Broad hallux (HP:0010055)2.05207087
122Oculomotor apraxia (HP:0000657)2.02715990
123Congenital, generalized hypertrichosis (HP:0004540)2.02349923
124Absent speech (HP:0001344)2.02152281
125Severe Myopia (HP:0011003)2.02070970
126Narrow forehead (HP:0000341)2.02059715
127Bony spicule pigmentary retinopathy (HP:0007737)2.00140230
128Hyperphosphatemia (HP:0002905)1.99384907
129Sparse lateral eyebrow (HP:0005338)1.99161877
130Thoracolumbar scoliosis (HP:0002944)1.98195447
131Plantar hyperkeratosis (HP:0007556)1.98143719
132Hyperparathyroidism (HP:0000843)1.97623583
133Drooling (HP:0002307)1.97497593
134Gout (HP:0001997)1.97470525
135Congenital primary aphakia (HP:0007707)1.96631098
136Emphysema (HP:0002097)1.95783663
137Increased hepatocellular lipid droplets (HP:0006565)1.95731528
138Vacuolated lymphocytes (HP:0001922)1.95285505
139Rib fusion (HP:0000902)1.93760659
140Short tibia (HP:0005736)1.92284793
141Gaze-evoked nystagmus (HP:0000640)1.90890297
142Abnormality of the epiphyses of the hand (HP:0005924)1.88775269
143Broad-based gait (HP:0002136)1.88686397
144Aplasia cutis congenita (HP:0001057)1.88456376
145Abnormal respiratory motile cilium physiology (HP:0012261)1.88318928
146Bilateral microphthalmos (HP:0007633)1.87586374
147Erythema (HP:0010783)1.87008853
148Advanced eruption of teeth (HP:0006288)1.86627970
149Abolished electroretinogram (ERG) (HP:0000550)1.85326282
150Hypergonadotropic hypogonadism (HP:0000815)1.85234722
151Attenuation of retinal blood vessels (HP:0007843)1.85136530
152Progressive macrocephaly (HP:0004481)1.84675854
153Aplasia/Hypoplasia of the ulna (HP:0006495)1.84586142
154Broad toe (HP:0001837)1.83592985
155Lipid accumulation in hepatocytes (HP:0006561)1.83441881
156Nasal polyposis (HP:0100582)1.82729967
157Type 2 muscle fiber atrophy (HP:0003554)1.82704544
158Widely patent fontanelles and sutures (HP:0004492)1.82698264
159Morphological abnormality of the inner ear (HP:0011390)1.82282685
160Pendular nystagmus (HP:0012043)1.79032211
161Cerebellar dysplasia (HP:0007033)1.78693940
162Widely spaced teeth (HP:0000687)1.78012031
163Amyloidosis (HP:0011034)1.77854028
164Excessive salivation (HP:0003781)1.77236635
165Parakeratosis (HP:0001036)1.77128445
166Stenosis of the external auditory canal (HP:0000402)1.76692854
167Adactyly (HP:0009776)1.75181756
168Preaxial hand polydactyly (HP:0001177)1.74031183
169Pachygyria (HP:0001302)1.73934729
170Exertional dyspnea (HP:0002875)1.73831277
171Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.72764177
172Postaxial foot polydactyly (HP:0001830)1.72630319
173Polyphagia (HP:0002591)1.72349949
174Aganglionic megacolon (HP:0002251)1.71916513
175Cerebral edema (HP:0002181)1.71855539
176Optic nerve coloboma (HP:0000588)1.71640755
177Pili torti (HP:0003777)1.71612174
178Abnormality of alanine metabolism (HP:0010916)1.71409452
179Hyperalaninemia (HP:0003348)1.71409452
180Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71409452
181Abnormality of the labia minora (HP:0012880)1.71368783
182Hypoplastic nipples (HP:0002557)1.70961484
183Progressive inability to walk (HP:0002505)1.70639523
184Hypohidrosis (HP:0000966)1.70055662
185Urticaria (HP:0001025)1.67817693
186Protuberant abdomen (HP:0001538)1.66418795
187Reticulocytopenia (HP:0001896)1.66409414
188Abnormal hemoglobin (HP:0011902)1.64975682
189Hypoplasia of the iris (HP:0007676)1.63913775
190Hypoplasia of dental enamel (HP:0006297)1.62589255
191Male infertility (HP:0003251)1.59296038
192Ulnar deviation of finger (HP:0009465)1.58767060
193Cutaneous finger syndactyly (HP:0010554)1.58333632
194Hypodontia (HP:0000668)1.57824564
195Abnormality of calcium-phosphate metabolism (HP:0100530)1.57767370
196Subcapsular cataract (HP:0000523)1.54245653

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.05477179
2ERN14.34841108
3CASK3.94070332
4ADRBK23.62608546
5STK38L3.15669957
6STK393.14425587
7SIK22.99331304
8TLK12.64952313
9STK32.62676983
10MUSK2.55833498
11ZAK2.55235075
12STK242.53859777
13ACVR1B2.49905242
14EEF2K2.39953124
15AKT32.22667173
16BMPR1B2.17765810
17MAPKAPK32.12491311
18SIK12.10999162
19MAP3K62.09934874
20PIK3CG2.06576759
21BCR2.06193227
22MST42.03415489
23CAMK1D2.00230324
24PTK2B1.87256050
25MELK1.86775112
26PDK41.71105294
27PDK31.71105294
28EPHA31.66112125
29PIK3CA1.65892795
30PDK21.65070514
31NEK21.63792919
32TAOK31.62910846
33NUAK11.61652634
34FER1.60872990
35STK161.60093868
36DYRK21.57807224
37PAK31.46921072
38OXSR11.46770181
39PNCK1.41591275
40MAP4K21.40782125
41BCKDK1.38146063
42MAPK131.38084925
43STK381.37193769
44CAMK1G1.28563612
45MATK1.26883899
46WNK31.24805533
47GRK11.23030106
48PTK61.20309965
49ERBB41.19038680
50MAP3K111.18771472
51MARK11.18705324
52LIMK11.18147887
53INSRR1.08922924
54EPHA41.08782669
55PRKCG1.07836167
56TGFBR11.02803668
57LMTK20.99795594
58MAPK150.97662587
59LATS20.93989601
60BTK0.93776845
61TEC0.93236860
62MAP2K70.90546290
63RPS6KB20.89009007
64LRRK20.88097457
65MAP3K90.86962666
66ERBB20.86862882
67EPHB10.83873133
68KSR20.83349655
69RET0.80866053
70BMX0.80492955
71STK110.79136371
72MAP3K30.78781948
73CDK90.77402679
74CAMK2A0.74232727
75SGK20.74192398
76PRKCZ0.74149129
77MAP3K40.71890060
78HIPK20.71208045
79MAP3K70.70199750
80GRK50.70123463
81TIE10.69762297
82PHKG20.69592843
83PHKG10.69592843
84DAPK20.68191668
85TNK20.67904945
86PKN20.67387316
87PRKCI0.66709273
88EPHA20.65757241
89MAPK110.65198616
90RPS6KA50.64847156
91PASK0.63928115
92FRK0.63271455
93PIM20.62962950
94VRK20.62115432
95PRKAA20.59837687
96TRIB30.59068634
97PKN10.58279679
98PRKCQ0.56915041
99EPHB20.55685465
100BMPR20.55396098
101NTRK10.55173657
102ARAF0.54581219
103PRKACA0.53937503
104MOS0.53498155
105ABL10.53469250
106TRPM70.52597347
107CAMK10.52258185
108PRKD30.51788009
109JAK20.51561818
110PRKAA10.51474519
111FLT30.51439539
112PDGFRB0.49872434
113NLK0.49775160
114MAP3K20.49356771
115MAPKAPK50.46293878
116PRKG10.45639122
117ABL20.45424615
118PLK20.44201794
119DMPK0.43843283
120MINK10.43406693
121TAF10.43284969
122CAMKK20.40383915
123PRKCA0.40078335
124NTRK20.39184485
125PRKCH0.37893596
126PLK10.37761654
127TGFBR20.37327416
128RPS6KA20.37275425
129MAP3K120.37153820
130IKBKB0.36453726
131CSNK1A1L0.36346937
132ERBB30.36331955
133MKNK10.36095613
134BRAF0.35938023
135JAK10.35740231
136CSNK1A10.34883983
137CSNK1G30.33588509
138CSNK1G10.33291155
139PLK40.32832577
140STK100.32482104
141PRKD20.31723506
142PRKD10.31447168
143MAP2K10.31176474
144MET0.31008926
145PTK20.30929815
146IRAK10.30734008
147WNK40.30551364
148CSNK1G20.28510345
149TAOK10.28164632
150MST1R0.27150888
151SGK4940.27065840
152SGK2230.27065840
153PRKCE0.26923840
154RAF10.25910258
155ICK0.25846202
156MYLK0.25430964
157GSK3A0.23745815
158PAK60.23083728
159AKT20.22865651
160IGF1R0.21003838
161ADRBK10.19813180
162MAP2K60.17916117
163PINK10.17523390
164ROCK10.17298205

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000617.38627082
2Caffeine metabolism_Homo sapiens_hsa002326.36133599
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006014.26041229
4Sulfur relay system_Homo sapiens_hsa041223.06080110
5Linoleic acid metabolism_Homo sapiens_hsa005913.02553477
6Nitrogen metabolism_Homo sapiens_hsa009102.84898464
7Phototransduction_Homo sapiens_hsa047442.66442481
8Oxidative phosphorylation_Homo sapiens_hsa001902.41246375
9Galactose metabolism_Homo sapiens_hsa000522.38915212
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.36814465
11Nicotine addiction_Homo sapiens_hsa050332.25130700
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.19309323
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.10601714
14Propanoate metabolism_Homo sapiens_hsa006401.92601747
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.90742702
16Ether lipid metabolism_Homo sapiens_hsa005651.85068723
17Parkinsons disease_Homo sapiens_hsa050121.73996262
18Arachidonic acid metabolism_Homo sapiens_hsa005901.73242202
19TGF-beta signaling pathway_Homo sapiens_hsa043501.64568389
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63755681
21Sulfur metabolism_Homo sapiens_hsa009201.62234730
22Prolactin signaling pathway_Homo sapiens_hsa049171.61470073
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60625494
24Fatty acid metabolism_Homo sapiens_hsa012121.56703663
25Regulation of autophagy_Homo sapiens_hsa041401.56613098
26Protein export_Homo sapiens_hsa030601.56024122
27Basal transcription factors_Homo sapiens_hsa030221.51571842
28Basal cell carcinoma_Homo sapiens_hsa052171.50539815
29Morphine addiction_Homo sapiens_hsa050321.49523319
30Hippo signaling pathway_Homo sapiens_hsa043901.49124775
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.48575705
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.47180931
33Taste transduction_Homo sapiens_hsa047421.46290223
34Fatty acid elongation_Homo sapiens_hsa000621.42449245
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.41798537
36Cardiac muscle contraction_Homo sapiens_hsa042601.40649285
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39447769
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38670674
39Huntingtons disease_Homo sapiens_hsa050161.35525052
40Tryptophan metabolism_Homo sapiens_hsa003801.34565530
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.31800649
42Serotonergic synapse_Homo sapiens_hsa047261.23366116
43PPAR signaling pathway_Homo sapiens_hsa033201.23256229
44Alzheimers disease_Homo sapiens_hsa050101.22380733
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22112737
46Butanoate metabolism_Homo sapiens_hsa006501.21665087
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20157121
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19950280
49Pyruvate metabolism_Homo sapiens_hsa006201.19254567
50Retinol metabolism_Homo sapiens_hsa008301.17921299
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15827985
52GABAergic synapse_Homo sapiens_hsa047271.14553076
53Adherens junction_Homo sapiens_hsa045201.13914370
54Folate biosynthesis_Homo sapiens_hsa007901.12440520
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06159953
56Melanoma_Homo sapiens_hsa052181.04895126
57Chemical carcinogenesis_Homo sapiens_hsa052041.04753659
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03835867
59Tight junction_Homo sapiens_hsa045301.02422483
60One carbon pool by folate_Homo sapiens_hsa006701.01224383
61Glutamatergic synapse_Homo sapiens_hsa047240.99854918
62RNA polymerase_Homo sapiens_hsa030200.99548462
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.97483481
64N-Glycan biosynthesis_Homo sapiens_hsa005100.93893923
65Other glycan degradation_Homo sapiens_hsa005110.87758768
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87221971
67Steroid biosynthesis_Homo sapiens_hsa001000.85306656
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.83949783
69Selenocompound metabolism_Homo sapiens_hsa004500.82947200
70Circadian entrainment_Homo sapiens_hsa047130.80256643
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80220616
72Renin-angiotensin system_Homo sapiens_hsa046140.79935283
73Mineral absorption_Homo sapiens_hsa049780.79850433
74Pancreatic cancer_Homo sapiens_hsa052120.79199517
75Fanconi anemia pathway_Homo sapiens_hsa034600.78377378
76Homologous recombination_Homo sapiens_hsa034400.78072990
77Fatty acid degradation_Homo sapiens_hsa000710.74676266
78Melanogenesis_Homo sapiens_hsa049160.73070257
79Bladder cancer_Homo sapiens_hsa052190.70606624
80Calcium signaling pathway_Homo sapiens_hsa040200.69859381
81Ovarian steroidogenesis_Homo sapiens_hsa049130.69432574
82Insulin secretion_Homo sapiens_hsa049110.68360571
83Cholinergic synapse_Homo sapiens_hsa047250.66741276
84Sphingolipid metabolism_Homo sapiens_hsa006000.65724289
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63502569
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63458250
87Hedgehog signaling pathway_Homo sapiens_hsa043400.62619549
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61567692
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.60357475
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.59681237
91Proteoglycans in cancer_Homo sapiens_hsa052050.58804801
92Dopaminergic synapse_Homo sapiens_hsa047280.58633451
93Metabolic pathways_Homo sapiens_hsa011000.57895487
94Asthma_Homo sapiens_hsa053100.57746042
95ECM-receptor interaction_Homo sapiens_hsa045120.57242340
96Hepatitis C_Homo sapiens_hsa051600.57074851
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55352352
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55103726
99Amoebiasis_Homo sapiens_hsa051460.54453753
100Wnt signaling pathway_Homo sapiens_hsa043100.54444048
101Circadian rhythm_Homo sapiens_hsa047100.54360025
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53990219
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53127124
104ErbB signaling pathway_Homo sapiens_hsa040120.52031969
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.51169184
106Salivary secretion_Homo sapiens_hsa049700.50945993
107Prostate cancer_Homo sapiens_hsa052150.50163182
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48780771
109Vibrio cholerae infection_Homo sapiens_hsa051100.48695213
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48128384
111Glycerolipid metabolism_Homo sapiens_hsa005610.47784074
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.47783027
113Insulin resistance_Homo sapiens_hsa049310.46254925
114Gastric acid secretion_Homo sapiens_hsa049710.45655729
115Starch and sucrose metabolism_Homo sapiens_hsa005000.45525451
116Vitamin digestion and absorption_Homo sapiens_hsa049770.45305609
117Pyrimidine metabolism_Homo sapiens_hsa002400.45262249
118Rap1 signaling pathway_Homo sapiens_hsa040150.45029884
119Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44884858
120Ras signaling pathway_Homo sapiens_hsa040140.42642785
121AMPK signaling pathway_Homo sapiens_hsa041520.42571293
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.42482341
123Long-term depression_Homo sapiens_hsa047300.42079106
124Nucleotide excision repair_Homo sapiens_hsa034200.41825204
125Histidine metabolism_Homo sapiens_hsa003400.41790627
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41655323
127Peroxisome_Homo sapiens_hsa041460.40861202
128Pathways in cancer_Homo sapiens_hsa052000.40690486
129Dorso-ventral axis formation_Homo sapiens_hsa043200.40516193
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40194513
131Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39629170
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38744381
133Tyrosine metabolism_Homo sapiens_hsa003500.38545500
134Purine metabolism_Homo sapiens_hsa002300.38172507
135Endocytosis_Homo sapiens_hsa041440.37049741
136beta-Alanine metabolism_Homo sapiens_hsa004100.36795758
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34949007
138Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34067885
139ABC transporters_Homo sapiens_hsa020100.33156628
140Protein digestion and absorption_Homo sapiens_hsa049740.32398373
141AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32279837
142FoxO signaling pathway_Homo sapiens_hsa040680.32099701
143Small cell lung cancer_Homo sapiens_hsa052220.31847971
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31831905
145Arginine biosynthesis_Homo sapiens_hsa002200.31416975
146Phenylalanine metabolism_Homo sapiens_hsa003600.28672498
147Glutathione metabolism_Homo sapiens_hsa004800.27296912
148Estrogen signaling pathway_Homo sapiens_hsa049150.26793543
149Hematopoietic cell lineage_Homo sapiens_hsa046400.26687648
150MicroRNAs in cancer_Homo sapiens_hsa052060.26407661
151Renin secretion_Homo sapiens_hsa049240.26390770
152Collecting duct acid secretion_Homo sapiens_hsa049660.24728779
153Ribosome_Homo sapiens_hsa030100.24588520
154Olfactory transduction_Homo sapiens_hsa047400.24552517
155Thyroid hormone synthesis_Homo sapiens_hsa049180.24302921
156Fat digestion and absorption_Homo sapiens_hsa049750.23949494
157Thyroid cancer_Homo sapiens_hsa052160.23782637
158Endometrial cancer_Homo sapiens_hsa052130.23653483
159Amphetamine addiction_Homo sapiens_hsa050310.23596359
160Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22602725
161Acute myeloid leukemia_Homo sapiens_hsa052210.22504010
162Axon guidance_Homo sapiens_hsa043600.21951528

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